ZBTB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.38940105
2mitotic metaphase plate congression (GO:0007080)5.24362368
3monoubiquitinated protein deubiquitination (GO:0035520)5.21740988
4nuclear pore organization (GO:0006999)5.04707006
5regulation of RNA export from nucleus (GO:0046831)5.01545583
6regulation of spindle organization (GO:0090224)4.45392343
7metaphase plate congression (GO:0051310)4.44890697
8histone H2A monoubiquitination (GO:0035518)4.29424176
9pore complex assembly (GO:0046931)4.20299567
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.12425670
11mitotic sister chromatid cohesion (GO:0007064)4.05259705
12artery development (GO:0060840)3.98143474
13protein localization to kinetochore (GO:0034501)3.94043231
14positive regulation of mitotic sister chromatid separation (GO:1901970)3.91857684
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91857684
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91857684
17positive regulation of chromosome segregation (GO:0051984)3.91728742
18mitotic chromosome condensation (GO:0007076)3.89311336
19regulation of nucleobase-containing compound transport (GO:0032239)3.81949288
20microtubule depolymerization (GO:0007019)3.79944972
21regulation of establishment of cell polarity (GO:2000114)3.76749861
22DNA replication checkpoint (GO:0000076)3.76519807
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.74345582
24protein localization to chromosome, centromeric region (GO:0071459)3.72944461
25intestinal epithelial cell development (GO:0060576)3.71598380
26regulation of mitotic spindle organization (GO:0060236)3.61256926
27purine nucleobase biosynthetic process (GO:0009113)3.57498253
28mitotic nuclear envelope disassembly (GO:0007077)3.47139418
29regulation of sister chromatid cohesion (GO:0007063)3.45237655
30ribosome assembly (GO:0042255)3.43808568
31somite rostral/caudal axis specification (GO:0032525)3.41439815
32establishment of chromosome localization (GO:0051303)3.40047675
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38842080
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.38842080
35regulation of translation, ncRNA-mediated (GO:0045974)3.38842080
36kinetochore assembly (GO:0051382)3.35067244
37protein localization to chromosome (GO:0034502)3.33308732
38nuclear envelope disassembly (GO:0051081)3.31003168
39membrane disassembly (GO:0030397)3.31003168
40gastrulation with mouth forming second (GO:0001702)3.29535322
41paraxial mesoderm development (GO:0048339)3.27696482
42limb bud formation (GO:0060174)3.26021924
43spindle checkpoint (GO:0031577)3.26002088
44negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.25497895
45sister chromatid cohesion (GO:0007062)3.25322662
46snRNA transcription (GO:0009301)3.24615227
47histone H2A ubiquitination (GO:0033522)3.24061911
48regulation of establishment or maintenance of cell polarity (GO:0032878)3.21637135
49branching involved in prostate gland morphogenesis (GO:0060442)3.19948909
50maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19821121
51attachment of spindle microtubules to kinetochore (GO:0008608)3.15839864
52kinetochore organization (GO:0051383)3.15079594
53histone demethylation (GO:0016577)3.14532148
54regulation of chromosome segregation (GO:0051983)3.13969171
55regulation of hippo signaling (GO:0035330)3.13874410
56histone lysine demethylation (GO:0070076)3.13459150
57embryonic retina morphogenesis in camera-type eye (GO:0060059)3.11913521
58presynaptic membrane assembly (GO:0097105)3.11748015
59interkinetic nuclear migration (GO:0022027)3.06997711
60DNA replication-independent nucleosome assembly (GO:0006336)3.06789195
61DNA replication-independent nucleosome organization (GO:0034724)3.06789195
62genitalia morphogenesis (GO:0035112)3.05676862
63embryonic foregut morphogenesis (GO:0048617)3.04824616
64protein K6-linked ubiquitination (GO:0085020)3.04448824
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02045381
66regulation of telomere maintenance via telomerase (GO:0032210)2.98861504
67pre-miRNA processing (GO:0031054)2.98773824
68cytoplasmic mRNA processing body assembly (GO:0033962)2.98498124
69inner cell mass cell proliferation (GO:0001833)2.98304311
70chromosome segregation (GO:0007059)2.97509196
71prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.97133703
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96849218
73regulation of transcription from RNA polymerase I promoter (GO:0006356)2.95625370
74nucleobase biosynthetic process (GO:0046112)2.95394526
75regulation of transforming growth factor beta2 production (GO:0032909)2.92589074
76histone exchange (GO:0043486)2.91284807
77presynaptic membrane organization (GO:0097090)2.90299916
78negative regulation of histone methylation (GO:0031061)2.89846162
79ribosome biogenesis (GO:0042254)2.89295550
80mitotic spindle checkpoint (GO:0071174)2.88085444
81mitotic sister chromatid segregation (GO:0000070)2.87470619
82meiotic chromosome segregation (GO:0045132)2.85871328
83piRNA metabolic process (GO:0034587)2.85403724
84synaptonemal complex assembly (GO:0007130)2.85251397
85protein K11-linked deubiquitination (GO:0035871)2.83205947
86negative regulation of DNA repair (GO:0045738)2.83173322
87lung-associated mesenchyme development (GO:0060484)2.81762894
88regulation of mitotic sister chromatid separation (GO:0010965)2.81530139
89regulation of mitotic sister chromatid segregation (GO:0033047)2.81530139
90regulation of sister chromatid segregation (GO:0033045)2.81530139
91protein demethylation (GO:0006482)2.79364409
92protein dealkylation (GO:0008214)2.79364409
93vitamin transmembrane transport (GO:0035461)2.79135868
94notochord development (GO:0030903)2.79064442
95sister chromatid segregation (GO:0000819)2.78956074
96CENP-A containing nucleosome assembly (GO:0034080)2.78891851
97histone monoubiquitination (GO:0010390)2.76666180
98histone H3-K9 demethylation (GO:0033169)2.76382041
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.75596967
100negative regulation of chromosome segregation (GO:0051985)2.74834051
101nuclear envelope organization (GO:0006998)2.74197109
102regulation of meiosis I (GO:0060631)2.72920136
103spindle assembly checkpoint (GO:0071173)2.72862713
104ectodermal placode formation (GO:0060788)2.72097893
105neural tube formation (GO:0001841)2.71350351
106DNA damage induced protein phosphorylation (GO:0006975)2.70347119
107replication fork processing (GO:0031297)2.69572428
108male meiosis I (GO:0007141)2.69482825
109mitotic spindle assembly checkpoint (GO:0007094)2.69243376
110nucleus organization (GO:0006997)2.68570300
111meiosis I (GO:0007127)2.67481321
112regulation of centriole replication (GO:0046599)2.67402333
113histone H3-K9 methylation (GO:0051567)2.67401930
114regulation of double-strand break repair via homologous recombination (GO:0010569)2.67365488
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.67338731
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67338731
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67338731
118negative regulation of sister chromatid segregation (GO:0033046)2.67338731
119histone H3-K4 trimethylation (GO:0080182)2.67147461
120interferon-gamma secretion (GO:0072643)2.66672136
121dorsal/ventral axis specification (GO:0009950)2.65319288
122regulation of DNA endoreduplication (GO:0032875)2.65202589
123histone ubiquitination (GO:0016574)2.64894610
124neuron fate determination (GO:0048664)2.64765159
125negative regulation of fibroblast apoptotic process (GO:2000270)2.64411397
126chromatin remodeling at centromere (GO:0031055)2.63805644
127peptidyl-lysine trimethylation (GO:0018023)2.62290012
128otic vesicle formation (GO:0030916)2.61825078
129embryonic axis specification (GO:0000578)2.59671085
130nucleus localization (GO:0051647)2.58048465
131embryonic pattern specification (GO:0009880)2.56574717
132retina layer formation (GO:0010842)2.54095609
133positive regulation of neuroblast proliferation (GO:0002052)2.54075065
134neuronal stem cell maintenance (GO:0097150)2.53708446
135central nervous system projection neuron axonogenesis (GO:0021952)2.52799835
136regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52522740
137negative regulation of smooth muscle cell differentiation (GO:0051151)2.51350224
138regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46986997
139appendage development (GO:0048736)2.46433420
140limb development (GO:0060173)2.46433420
141axonal fasciculation (GO:0007413)2.44377678
142somite development (GO:0061053)2.43481454
143regulation of NFAT protein import into nucleus (GO:0051532)2.42875891
144negative regulation of astrocyte differentiation (GO:0048712)2.41204247
145pancreas development (GO:0031016)2.38521288
146auditory receptor cell differentiation (GO:0042491)2.36649802
147embryonic camera-type eye morphogenesis (GO:0048596)2.36306096
148microtubule anchoring (GO:0034453)2.36131426
149negative regulation of neurotransmitter secretion (GO:0046929)2.29727938
150NLS-bearing protein import into nucleus (GO:0006607)2.29718531
151cerebral cortex development (GO:0021987)2.29336799
152regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.29269249
153establishment of nucleus localization (GO:0040023)2.29206052
154positive regulation of gastrulation (GO:2000543)2.28825756
155prostate gland growth (GO:0060736)2.28519430
156positive regulation of mRNA processing (GO:0050685)2.27502186
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27412502
158anterior/posterior axis specification (GO:0009948)2.26408253
159central nervous system neuron axonogenesis (GO:0021955)2.25471072
160forebrain neuron differentiation (GO:0021879)2.24748685
161spermatid nucleus differentiation (GO:0007289)2.22908958
162centriole replication (GO:0007099)2.22249563
163establishment of protein localization to Golgi (GO:0072600)2.20569389
164regulation of centrosome duplication (GO:0010824)2.20504782
165primitive streak formation (GO:0090009)2.20261071
166hindbrain development (GO:0030902)2.19999066
167ventricular septum morphogenesis (GO:0060412)2.18131608
168retinal ganglion cell axon guidance (GO:0031290)2.17825324
169positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.17554985
170positive regulation of embryonic development (GO:0040019)2.17473306
171apical protein localization (GO:0045176)2.16849015
172histone lysine methylation (GO:0034968)2.15808502
173positive regulation by host of viral transcription (GO:0043923)2.13877838
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.13794395
175histone H3-K9 modification (GO:0061647)2.13458188
176negative regulation of oligodendrocyte differentiation (GO:0048715)2.13153015
177regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.12632463
178positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.12632463
179olfactory bulb development (GO:0021772)2.12293245
180coronary vasculature morphogenesis (GO:0060977)2.12066663
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11292425
182peptidyl-lysine methylation (GO:0018022)2.10616486
183intraciliary transport (GO:0042073)2.10561623
184negative regulation of keratinocyte proliferation (GO:0010839)2.09820941
185kidney morphogenesis (GO:0060993)2.09706188
186negative regulation of JUN kinase activity (GO:0043508)2.09061091
187cerebral cortex radially oriented cell migration (GO:0021799)2.08756058
188heart morphogenesis (GO:0003007)2.08733699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80895864
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.25563114
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.53542265
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79686051
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.65991375
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.65370103
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28374861
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27020300
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70248801
10* AR_21909140_ChIP-Seq_LNCAP_Human2.64696665
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63864975
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.58051966
13GBX2_23144817_ChIP-Seq_PC3_Human2.54939643
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50119614
15FUS_26573619_Chip-Seq_HEK293_Human2.45164347
16EZH2_22144423_ChIP-Seq_EOC_Human2.41244379
17TAF15_26573619_Chip-Seq_HEK293_Human2.32664488
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.31442199
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30282944
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28552936
21IGF1R_20145208_ChIP-Seq_DFB_Human2.26794886
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20261993
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18158917
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14431064
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06130152
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.04121146
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.99076579
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.96575194
29* P300_19829295_ChIP-Seq_ESCs_Human1.93751056
30VDR_22108803_ChIP-Seq_LS180_Human1.86725942
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85837082
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84710878
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84574604
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.83503289
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81651713
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80708681
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80035785
38AR_21572438_ChIP-Seq_LNCaP_Human1.79214962
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78785699
40ZNF274_21170338_ChIP-Seq_K562_Hela1.78185788
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76860061
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75838779
43* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74555183
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71662003
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68317347
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.67078624
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65878782
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.65418498
49SMAD4_21799915_ChIP-Seq_A2780_Human1.64024223
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61035048
51ER_23166858_ChIP-Seq_MCF-7_Human1.59277366
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57311810
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57311810
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57311810
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.55493293
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54834259
57KDM5A_27292631_Chip-Seq_BREAST_Human1.53921945
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52600324
59* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52315027
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51873298
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51129142
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50549024
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.49880994
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49860796
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49548281
66* RNF2_27304074_Chip-Seq_NSC_Mouse1.49177630
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48728625
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48302919
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48128632
70STAT3_23295773_ChIP-Seq_U87_Human1.47303327
71* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44849858
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.44798599
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44470364
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43651552
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.42875957
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41977783
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40721679
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.40482478
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40002271
80VDR_23849224_ChIP-Seq_CD4+_Human1.39695159
81ZNF263_19887448_ChIP-Seq_K562_Human1.39568818
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38480890
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38366344
84AHR_22903824_ChIP-Seq_MCF-7_Human1.37491147
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37409251
86* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36829760
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36737685
88* AR_25329375_ChIP-Seq_VCAP_Human1.36510172
89* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36391428
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33970330
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33916542
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31460903
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31231145
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31027082
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30605110
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29839337
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29393307
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28742909
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28375236
100* TCF4_23295773_ChIP-Seq_U87_Human1.28303080
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28166511
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27629029
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27162381
104ELK1_19687146_ChIP-ChIP_HELA_Human1.25343694
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24815617
106* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24577886
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23000628
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22582494
109CBP_20019798_ChIP-Seq_JUKART_Human1.22582494
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21958940
111* EZH2_27304074_Chip-Seq_ESCs_Mouse1.21571590
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19876926
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17546788
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16722425
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.16240519
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15379383
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.14561193
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13256911
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13157238
120RUNX2_22187159_ChIP-Seq_PCA_Human1.12558814
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11920857
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11408613
123BCAT_22108803_ChIP-Seq_LS180_Human1.10301002
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08438092
125* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08366308
126EWS_26573619_Chip-Seq_HEK293_Human1.08321915
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07093384
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07085013
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07085013
130UBF1/2_26484160_Chip-Seq_HMECs_Human1.06924491
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06924072
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06174556
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06088495
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05972999
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05719760
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05618707
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05232297
138* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05169650
139CHD1_26751641_Chip-Seq_LNCaP_Human1.04783818
140ISL1_27105846_Chip-Seq_CPCs_Mouse1.04596857
141* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04596467
142BRD4_25478319_ChIP-Seq_HGPS_Human1.04573150
143GABP_17652178_ChIP-ChIP_JURKAT_Human1.03804623
144TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03680419
145SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02372342
146* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02134128
147SOX9_26525672_Chip-Seq_HEART_Mouse1.02118492
148PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01232136
149* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00991780
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00659504
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.99657109
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99018733
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98892050
154* TCF4_22108803_ChIP-Seq_LS180_Human0.98792967
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98222472
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97897075
157POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95937912
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95092250
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93549854
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.92962533
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92894352
162GABP_19822575_ChIP-Seq_HepG2_Human0.91495849
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90835930
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90738384
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90738384
166XRN2_22483619_ChIP-Seq_HELA_Human0.90407516
167TTF2_22483619_ChIP-Seq_HELA_Human0.88014903
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87784901
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87242177
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.86649137
171ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86574153
172TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86516179
173EST1_17652178_ChIP-ChIP_JURKAT_Human0.84643456
174TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84286318
175KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84224607
176POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84094356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.86857890
2MP0003693_abnormal_embryo_hatching3.77399326
3MP0003111_abnormal_nucleus_morphology3.17837839
4MP0003077_abnormal_cell_cycle3.04435104
5MP0010094_abnormal_chromosome_stability2.73458000
6MP0004957_abnormal_blastocyst_morpholog2.60261509
7MP0008007_abnormal_cellular_replicative2.44903796
8MP0003123_paternal_imprinting2.33064215
9MP0003121_genomic_imprinting2.21133014
10MP0008877_abnormal_DNA_methylation2.18629114
11MP0008058_abnormal_DNA_repair2.10977437
12MP0000778_abnormal_nervous_system2.08584795
13MP0001672_abnormal_embryogenesis/_devel2.06843319
14MP0005380_embryogenesis_phenotype2.06843319
15MP0002009_preneoplasia2.03164693
16MP0003937_abnormal_limbs/digits/tail_de2.02944600
17MP0003718_maternal_effect1.98361500
18MP0001730_embryonic_growth_arrest1.96074424
19MP0000350_abnormal_cell_proliferation1.95198643
20MP0003890_abnormal_embryonic-extraembry1.94907860
21MP0000631_abnormal_neuroendocrine_gland1.92957207
22MP0003984_embryonic_growth_retardation1.91097639
23MP0002088_abnormal_embryonic_growth/wei1.88419853
24MP0005076_abnormal_cell_differentiation1.87562655
25MP0002234_abnormal_pharynx_morphology1.80827850
26MP0010352_gastrointestinal_tract_polyps1.80538815
27MP0010307_abnormal_tumor_latency1.79315821
28MP0002084_abnormal_developmental_patter1.77394459
29MP0003136_yellow_coat_color1.75049288
30MP0002086_abnormal_extraembryonic_tissu1.71831100
31MP0001697_abnormal_embryo_size1.68959982
32MP0008961_abnormal_basal_metabolism1.65864660
33MP0002085_abnormal_embryonic_tissue1.65428277
34MP0003787_abnormal_imprinting1.62635034
35MP0004264_abnormal_extraembryonic_tissu1.60001216
36MP0003567_abnormal_fetal_cardiomyocyte1.58634223
37MP0002163_abnormal_gland_morphology1.58281881
38MP0006292_abnormal_olfactory_placode1.57995238
39MP0006072_abnormal_retinal_apoptosis1.54092827
40MP0008932_abnormal_embryonic_tissue1.50254210
41MP0002877_abnormal_melanocyte_morpholog1.48825745
42MP0002697_abnormal_eye_size1.47154140
43MP0002653_abnormal_ependyma_morphology1.43088971
44MP0002396_abnormal_hematopoietic_system1.39629230
45MP0002210_abnormal_sex_determination1.38551603
46MP0008995_early_reproductive_senescence1.35635009
47MP0003755_abnormal_palate_morphology1.35609764
48MP0004197_abnormal_fetal_growth/weight/1.34816683
49MP0000569_abnormal_digit_pigmentation1.30998858
50MP0003315_abnormal_perineum_morphology1.29269616
51MP0003935_abnormal_craniofacial_develop1.26773003
52MP0003880_abnormal_central_pattern1.25440617
53MP0001929_abnormal_gametogenesis1.23518643
54MP0003786_premature_aging1.22591420
55MP0010678_abnormal_skin_adnexa1.22527177
56MP0002080_prenatal_lethality1.21791945
57MP0005367_renal/urinary_system_phenotyp1.21648631
58MP0000516_abnormal_urinary_system1.21648631
59MP0002822_catalepsy1.20752808
60MP0005391_vision/eye_phenotype1.20705835
61MP0004808_abnormal_hematopoietic_stem1.18877629
62MP0005253_abnormal_eye_physiology1.18518154
63MP0003195_calcinosis1.17816321
64MP0003119_abnormal_digestive_system1.16494812
65MP0001145_abnormal_male_reproductive1.16002868
66MP0000428_abnormal_craniofacial_morphol1.15643233
67MP0000653_abnormal_sex_gland1.14957434
68MP0009053_abnormal_anal_canal1.14290328
69MP0000432_abnormal_head_morphology1.13239498
70MP0002557_abnormal_social/conspecific_i1.12113707
71MP0003122_maternal_imprinting1.12087833
72MP0005187_abnormal_penis_morphology1.11661630
73MP0002102_abnormal_ear_morphology1.11461184
74MP0005647_abnormal_sex_gland1.11265879
75MP0000647_abnormal_sebaceous_gland1.11215310
76MP0001485_abnormal_pinna_reflex1.10743748
77MP0003221_abnormal_cardiomyocyte_apopto1.10718461
78MP0004133_heterotaxia1.10627765
79MP0000566_synostosis1.09670379
80MP0003828_pulmonary_edema1.09366585
81MP0003938_abnormal_ear_development1.08712758
82MP0001293_anophthalmia1.08559980
83MP0000627_abnormal_mammary_gland1.08444287
84MP0005257_abnormal_intraocular_pressure1.08369770
85MP0005451_abnormal_body_composition1.08149941
86MP0009703_decreased_birth_body1.07625304
87MP0000537_abnormal_urethra_morphology1.07150925
88MP0001849_ear_inflammation1.07069112
89MP0009250_abnormal_appendicular_skeleto1.06857832
90MP0000955_abnormal_spinal_cord1.06499416
91MP0005646_abnormal_pituitary_gland1.06080844
92MP0002751_abnormal_autonomic_nervous1.06026366
93MP0000534_abnormal_ureter_morphology1.05504336
94MP0001486_abnormal_startle_reflex1.04715940
95MP0004185_abnormal_adipocyte_glucose1.03562813
96MP0001119_abnormal_female_reproductive1.03482262
97MP0002184_abnormal_innervation1.02622695
98MP0001502_abnormal_circadian_rhythm1.02258935
99MP0006276_abnormal_autonomic_nervous0.98908889
100MP0004145_abnormal_muscle_electrophysio0.98234221
101MP0003942_abnormal_urinary_system0.97468619
102MP0001286_abnormal_eye_development0.97391760
103MP0009672_abnormal_birth_weight0.96850968
104MP0002925_abnormal_cardiovascular_devel0.96156497
105MP0003943_abnormal_hepatobiliary_system0.96028339
106MP0005551_abnormal_eye_electrophysiolog0.93814073
107MP0005248_abnormal_Harderian_gland0.93485946
108MP0004742_abnormal_vestibular_system0.92817508
109MP0003936_abnormal_reproductive_system0.92765827
110MP0002928_abnormal_bile_duct0.91849696
111MP0002938_white_spotting0.91762913
112MP0000733_abnormal_muscle_development0.91438914
113MP0003705_abnormal_hypodermis_morpholog0.91362997
114MP0001346_abnormal_lacrimal_gland0.91285988
115MP0001879_abnormal_lymphatic_vessel0.90837370
116MP0003385_abnormal_body_wall0.90257718
117MP0000383_abnormal_hair_follicle0.88819975
118MP0000049_abnormal_middle_ear0.88312916
119MP0002152_abnormal_brain_morphology0.88119344
120MP0010030_abnormal_orbit_morphology0.86917235
121MP0002111_abnormal_tail_morphology0.85264590
122MP0002092_abnormal_eye_morphology0.84649758
123MP0001299_abnormal_eye_distance/0.83907818
124MP0002127_abnormal_cardiovascular_syste0.83659830
125MP0005386_behavior/neurological_phenoty0.83073936
126MP0004924_abnormal_behavior0.83073936
127MP0002638_abnormal_pupillary_reflex0.82152829
128MP0003699_abnormal_female_reproductive0.82056738
129MP0005195_abnormal_posterior_eye0.81801152
130MP0002233_abnormal_nose_morphology0.81660552
131MP0008789_abnormal_olfactory_epithelium0.81008540
132MP0005408_hypopigmentation0.80798275
133MP0005621_abnormal_cell_physiology0.80124423
134MP0002081_perinatal_lethality0.80062302
135MP0003941_abnormal_skin_development0.79554790
136MP0005310_abnormal_salivary_gland0.79521505
137MP0001944_abnormal_pancreas_morphology0.79443454
138MP0001324_abnormal_eye_pigmentation0.78422763
139MP0000767_abnormal_smooth_muscle0.78246988
140MP0009697_abnormal_copulation0.78231158
141MP0008260_abnormal_autophagy0.78153434
142MP0003646_muscle_fatigue0.77778553
143MP0003861_abnormal_nervous_system0.77712360
144MP0005395_other_phenotype0.76957415
145MP0003115_abnormal_respiratory_system0.76176634
146MP0000490_abnormal_crypts_of0.75664776
147MP0002116_abnormal_craniofacial_bone0.75107165
148MP0005508_abnormal_skeleton_morphology0.75101064

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.11163519
2Papillary thyroid carcinoma (HP:0002895)3.82173122
3Facial hemangioma (HP:0000329)3.80782223
4Abnormality of the labia minora (HP:0012880)3.55439103
5Impulsivity (HP:0100710)3.48041500
6Capillary hemangiomas (HP:0005306)3.42540520
7Breast hypoplasia (HP:0003187)3.28662989
8Patellar aplasia (HP:0006443)3.22389263
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19987619
10Shawl scrotum (HP:0000049)3.17760881
11Chromsome breakage (HP:0040012)3.13463642
12Aplasia/Hypoplasia of the patella (HP:0006498)3.04564519
13Intestinal atresia (HP:0011100)2.90218588
14Volvulus (HP:0002580)2.74880700
15Carpal bone hypoplasia (HP:0001498)2.64209193
16Abnormality of the fingertips (HP:0001211)2.59183409
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.56505933
18Hyperventilation (HP:0002883)2.52350141
19Flat capital femoral epiphysis (HP:0003370)2.52305677
20Meckel diverticulum (HP:0002245)2.48983236
21Prostate neoplasm (HP:0100787)2.46797315
22Midline defect of the nose (HP:0004122)2.42875503
23Ectopic kidney (HP:0000086)2.41986331
24Small epiphyses (HP:0010585)2.41334073
25Sparse lateral eyebrow (HP:0005338)2.38977139
26Oligodactyly (hands) (HP:0001180)2.34785581
27Cutaneous finger syndactyly (HP:0010554)2.33400505
28Abnormality of the ileum (HP:0001549)2.32118895
29Gonadotropin excess (HP:0000837)2.31259386
30Abnormality of chromosome stability (HP:0003220)2.28410156
31Oligodactyly (HP:0012165)2.27823456
32Chronic hepatic failure (HP:0100626)2.27387585
33Pancreatic cysts (HP:0001737)2.25840559
34Thyroid carcinoma (HP:0002890)2.22690081
35Genetic anticipation (HP:0003743)2.22054431
36Abnormality of the aortic arch (HP:0012303)2.18124223
37Absent radius (HP:0003974)2.17983932
38Prominent nose (HP:0000448)2.17697227
39Adrenal hypoplasia (HP:0000835)2.16585980
40Truncal obesity (HP:0001956)2.16105942
41Acute myeloid leukemia (HP:0004808)2.15732240
42Abnormality of the preputium (HP:0100587)2.13985095
43Supernumerary spleens (HP:0009799)2.12435335
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.07448356
45Megalencephaly (HP:0001355)2.07344565
46Irregular epiphyses (HP:0010582)2.07145090
47True hermaphroditism (HP:0010459)2.06770479
48Curly hair (HP:0002212)2.06665119
49Nephronophthisis (HP:0000090)2.06493437
50Breast aplasia (HP:0100783)2.06414826
51Abnormality of the renal medulla (HP:0100957)2.02470015
52Aqueductal stenosis (HP:0002410)2.02431962
53Drooling (HP:0002307)2.01766903
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.00220770
55Aplasia involving forearm bones (HP:0009822)1.99200186
56Absent forearm bone (HP:0003953)1.99200186
57Lip pit (HP:0100267)1.99135902
58Cutaneous syndactyly (HP:0012725)1.97297433
59Gastrointestinal atresia (HP:0002589)1.97215792
60Male infertility (HP:0003251)1.97080323
61Tubulointerstitial nephritis (HP:0001970)1.96838601
62Long eyelashes (HP:0000527)1.95999227
63Abnormality of the nasal septum (HP:0000419)1.95233844
64Cystic hygroma (HP:0000476)1.94019851
65Anophthalmia (HP:0000528)1.92459700
66Anal stenosis (HP:0002025)1.92138880
67Aplasia/Hypoplasia of the breasts (HP:0010311)1.91705248
68Abnormality of the 4th metacarpal (HP:0010012)1.91253675
69Febrile seizures (HP:0002373)1.87948577
70Bifid scrotum (HP:0000048)1.87840016
71Hypoplastic ischia (HP:0003175)1.87774333
72Increased number of teeth (HP:0011069)1.86430356
73Thickened helices (HP:0000391)1.86034563
74Neoplasm of the adrenal cortex (HP:0100641)1.84975261
75Fair hair (HP:0002286)1.84040686
76Cupped ear (HP:0000378)1.82813494
77Short thumb (HP:0009778)1.81819324
78Hepatoblastoma (HP:0002884)1.81691274
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81646347
80Myelodysplasia (HP:0002863)1.81618607
81Preaxial foot polydactyly (HP:0001841)1.80486693
82Neoplasm of the oral cavity (HP:0100649)1.80343601
83Pheochromocytoma (HP:0002666)1.80310326
84Overlapping toe (HP:0001845)1.80151057
85Ureteral duplication (HP:0000073)1.79823693
86Aplasia/Hypoplasia of the sternum (HP:0006714)1.79766350
87Renal hypoplasia (HP:0000089)1.78918503
882-3 toe syndactyly (HP:0004691)1.78327649
89Hamartoma (HP:0010566)1.76961282
90Vitreoretinal degeneration (HP:0000655)1.76066517
91Esophageal atresia (HP:0002032)1.75554177
92Hypoplastic labia majora (HP:0000059)1.75232094
93Microglossia (HP:0000171)1.75074332
94High anterior hairline (HP:0009890)1.74807970
95Abnormal spermatogenesis (HP:0008669)1.74577006
96Duodenal stenosis (HP:0100867)1.74272006
97Small intestinal stenosis (HP:0012848)1.74272006
98Broad thumb (HP:0011304)1.74024984
99Abnormality of the carotid arteries (HP:0005344)1.73419944
100Excessive salivation (HP:0003781)1.72804496
101Aplasia/hypoplasia of the humerus (HP:0006507)1.72362047
102Deviation of the thumb (HP:0009603)1.71003107
103Septo-optic dysplasia (HP:0100842)1.70520543
104Genital tract atresia (HP:0001827)1.69735075
105Depressed nasal tip (HP:0000437)1.69475967
106Heterotopia (HP:0002282)1.68893997
107Entropion (HP:0000621)1.68658132
108Atresia of the external auditory canal (HP:0000413)1.68468159
109Tented upper lip vermilion (HP:0010804)1.68454453
110Abnormality of midbrain morphology (HP:0002418)1.68237987
111Molar tooth sign on MRI (HP:0002419)1.68237987
112Vaginal atresia (HP:0000148)1.67666590
113Wrist flexion contracture (HP:0001239)1.67375014
114Abnormality of the septum pellucidum (HP:0007375)1.66745916
115Short tibia (HP:0005736)1.66331506
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65967694
117Short 4th metacarpal (HP:0010044)1.65967694
118Azoospermia (HP:0000027)1.65927492
119Glioma (HP:0009733)1.65806016
120Embryonal renal neoplasm (HP:0011794)1.65620735
121Stillbirth (HP:0003826)1.65601334
122Abnormality of the pubic bones (HP:0003172)1.65572917
123Bilateral microphthalmos (HP:0007633)1.64991178
124Ependymoma (HP:0002888)1.64900637
125Optic nerve hypoplasia (HP:0000609)1.64580087
126Abnormality of the astrocytes (HP:0100707)1.64510214
127Astrocytoma (HP:0009592)1.64510214
128Abnormal pancreas size (HP:0012094)1.64460360
129Bifid tongue (HP:0010297)1.64382534
130Colon cancer (HP:0003003)1.64118415
131Microtia (HP:0008551)1.62718013
132Broad phalanges of the hand (HP:0009768)1.62620357
133Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62523194
134Exotropia (HP:0000577)1.61677377
135Abnormality of abdominal situs (HP:0011620)1.60328724
136Abdominal situs inversus (HP:0003363)1.60328724
137Missing ribs (HP:0000921)1.60042333
138Short humerus (HP:0005792)1.60035081
139Segmental peripheral demyelination/remyelination (HP:0003481)1.58974513
140Arteriovenous malformation (HP:0100026)1.58389643
141Abnormality of chromosome segregation (HP:0002916)1.58271933
142Deep philtrum (HP:0002002)1.58255270
143Submucous cleft hard palate (HP:0000176)1.58233862
144Sandal gap (HP:0001852)1.58043194
145Muscle fiber splitting (HP:0003555)1.57955266
146Poor coordination (HP:0002370)1.57453693
147Proximal placement of thumb (HP:0009623)1.57436103
148Abnormality of the labia majora (HP:0012881)1.57363180
149Absent eyebrow (HP:0002223)1.57045958
150Overgrowth (HP:0001548)1.56751162
151Nephroblastoma (Wilms tumor) (HP:0002667)1.56649687
152Thoracolumbar scoliosis (HP:0002944)1.56527688
153Preaxial hand polydactyly (HP:0001177)1.55834596
154Broad phalanx (HP:0006009)1.55634109
155Broad finger (HP:0001500)1.55485843
156Medulloblastoma (HP:0002885)1.55391266
157Hip contracture (HP:0003273)1.54499363
158Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.54001142
159Abnormality of femoral epiphyses (HP:0006499)1.54001142
160Calf muscle hypertrophy (HP:0008981)1.53489191
161Abnormality of the epiphysis of the femoral head (HP:0010574)1.53477086
162Pancreatic fibrosis (HP:0100732)1.53366146
163Labial hypoplasia (HP:0000066)1.53223296
164Rhabdomyosarcoma (HP:0002859)1.52880212
165Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52642390
166Abnormality of the ischium (HP:0003174)1.52511932
167Blue irides (HP:0000635)1.52092527
168Abnormal biliary tract morphology (HP:0012440)1.51195310
169Obsessive-compulsive behavior (HP:0000722)1.51126540
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.50720164
171Abnormality of the parathyroid morphology (HP:0011766)1.50694737
172Large earlobe (HP:0009748)1.50350891
173Neoplasm of striated muscle (HP:0009728)1.49751411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.32105194
2LATS24.09660968
3STK38L4.01513983
4CASK3.74692494
5STK33.17143523
6CDK122.99021639
7WEE12.97974747
8PLK42.81666603
9AKT32.61330165
10NEK22.50443380
11TNIK2.47713196
12CDC72.38729049
13BRSK22.15754066
14MKNK22.07872890
15SRPK12.06649599
16ACVR1B1.98178281
17MAP3K41.93274063
18DYRK31.89758633
19FGFR21.85719287
20CHEK21.82223306
21STK391.67537712
22ERBB31.67508035
23PLK31.60027745
24MAP3K101.53406287
25PLK11.52435313
26NUAK11.50340442
27TTK1.45858039
28MAPK151.37660337
29MARK11.37617585
30TSSK61.35110844
31CDK81.34725430
32CDK71.34158735
33BMPR1B1.33184525
34FRK1.32044822
35MKNK11.30163834
36BUB11.29715169
37STK241.27449182
38CHEK11.24105524
39TRIM281.23425589
40AURKB1.18184487
41MELK1.15781073
42EPHA21.14806997
43PNCK1.13699799
44NTRK21.03980227
45SGK4941.03390606
46SGK2231.03390606
47MARK31.02193026
48DYRK21.01631406
49CDK31.01628288
50YES10.94632532
51STK380.92941578
52CDK40.91824355
53FER0.91020195
54ATM0.90102270
55FGFR10.89390965
56RPS6KA40.88975685
57MTOR0.86432024
58MAP3K60.85860286
59ZAK0.84999585
60PLK20.84830727
61MAP3K30.83574604
62BRD40.83220042
63CHUK0.83085642
64EPHA30.82714292
65OBSCN0.82277048
66IRAK10.82173349
67PRKAA10.81760103
68BCR0.80366216
69PDGFRB0.80249970
70EPHA40.80042109
71CDK20.79263099
72CDK90.79222356
73CSNK1G10.78054448
74CAMK1D0.78011175
75PIM10.77210311
76BRSK10.76965109
77MAPK130.76488147
78EEF2K0.74486261
79ATR0.72162873
80NLK0.71915600
81DMPK0.70405437
82CDK10.68532154
83PDK20.67884651
84EIF2AK30.64808429
85NTRK30.62973363
86DDR20.62512166
87ERBB40.62009371
88PIK3CA0.61778182
89DYRK1B0.61289518
90CSNK1A1L0.60631020
91PAK30.60339033
92CDK60.56457645
93SGK20.56029256
94MAP2K70.55164996
95TAOK10.53237917
96VRK10.53119649
97MAPK100.52338839
98KSR10.51925272
99GRK10.51468174
100SGK10.51304060
101NEK10.50912568
102INSRR0.49967453
103ALK0.49616478
104CCNB10.48727538
105CAMK40.47840118
106EIF2AK20.47042584
107PDK30.46645559
108PDK40.46645559
109PRKAA20.45808873
110NEK60.45653054
111PRKCI0.45077103
112PKN20.44929613
113RPS6KA50.43617472
114WNK40.43610133
115TAF10.43453360
116ERBB20.43359742
117AURKA0.43018015
118MAPK140.42130843
119TGFBR10.41899941
120GSK3A0.41556245
121ABL20.41102900
122PRKCE0.41011685
123STK100.40965770
124RAF10.40902844
125UHMK10.40807988
126OXSR10.40424903
127DYRK1A0.39818891
128TYRO30.38582894
129MAP3K80.38313718
130RPS6KB20.38303223
131GSK3B0.38301055
132CSNK1E0.37922397
133MST40.37827389
134WNK30.36409261
135CSNK1D0.36073129
136PASK0.35302208
137SGK30.35079317
138CAMK1G0.35059994
139ADRBK20.34803516
140CSNK1G20.34494245
141TNK20.34218916
142ABL10.33991656
143PDGFRA0.33743957
144RPS6KB10.33547195
145TAOK30.32188201
146MAPK10.31778065
147FGFR30.31136949

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56744244
2Cell cycle_Homo sapiens_hsa041103.10862440
3RNA polymerase_Homo sapiens_hsa030203.07901403
4Vitamin B6 metabolism_Homo sapiens_hsa007503.06705861
5RNA transport_Homo sapiens_hsa030133.03439366
6Basal transcription factors_Homo sapiens_hsa030222.90297766
7Fanconi anemia pathway_Homo sapiens_hsa034602.16544169
8mRNA surveillance pathway_Homo sapiens_hsa030152.14659131
9p53 signaling pathway_Homo sapiens_hsa041152.08079843
10Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.98152257
11Spliceosome_Homo sapiens_hsa030401.88785816
12MicroRNAs in cancer_Homo sapiens_hsa052061.76266733
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.74357347
14RNA degradation_Homo sapiens_hsa030181.70013678
15Circadian rhythm_Homo sapiens_hsa047101.67326044
16TGF-beta signaling pathway_Homo sapiens_hsa043501.64432835
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62358141
18Homologous recombination_Homo sapiens_hsa034401.58542595
19Hippo signaling pathway_Homo sapiens_hsa043901.54253143
20Small cell lung cancer_Homo sapiens_hsa052221.49369705
21Oocyte meiosis_Homo sapiens_hsa041141.42051847
22Adherens junction_Homo sapiens_hsa045201.36436702
23Prostate cancer_Homo sapiens_hsa052151.35949939
24Nucleotide excision repair_Homo sapiens_hsa034201.35749115
25Nicotine addiction_Homo sapiens_hsa050331.31646159
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30509498
27Epstein-Barr virus infection_Homo sapiens_hsa051691.30348416
28mTOR signaling pathway_Homo sapiens_hsa041501.27351463
29Renal cell carcinoma_Homo sapiens_hsa052111.24137180
30FoxO signaling pathway_Homo sapiens_hsa040681.22633745
31Cocaine addiction_Homo sapiens_hsa050301.22410937
32Fatty acid biosynthesis_Homo sapiens_hsa000611.18319218
33Regulation of autophagy_Homo sapiens_hsa041401.17550604
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15411142
35Alcoholism_Homo sapiens_hsa050341.14747689
36Endometrial cancer_Homo sapiens_hsa052131.14586823
37ABC transporters_Homo sapiens_hsa020101.12586691
38Herpes simplex infection_Homo sapiens_hsa051681.12378236
39Colorectal cancer_Homo sapiens_hsa052101.11778451
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.11326145
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09866564
42Mismatch repair_Homo sapiens_hsa034301.08443948
43Propanoate metabolism_Homo sapiens_hsa006401.08199974
44Circadian entrainment_Homo sapiens_hsa047131.07681862
45Pyrimidine metabolism_Homo sapiens_hsa002401.05510147
46Dorso-ventral axis formation_Homo sapiens_hsa043201.05422711
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04411095
48Viral carcinogenesis_Homo sapiens_hsa052031.02561369
49Axon guidance_Homo sapiens_hsa043601.02201193
50Prolactin signaling pathway_Homo sapiens_hsa049171.02003109
51Pancreatic cancer_Homo sapiens_hsa052121.00956843
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00392536
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99679763
54Steroid biosynthesis_Homo sapiens_hsa001000.99381167
55Type II diabetes mellitus_Homo sapiens_hsa049300.97686657
56Basal cell carcinoma_Homo sapiens_hsa052170.97522755
57HTLV-I infection_Homo sapiens_hsa051660.95197003
58Thyroid cancer_Homo sapiens_hsa052160.93707704
59Chronic myeloid leukemia_Homo sapiens_hsa052200.92370774
60Hedgehog signaling pathway_Homo sapiens_hsa043400.91808015
61Melanogenesis_Homo sapiens_hsa049160.91720999
62Amphetamine addiction_Homo sapiens_hsa050310.91253981
63Butanoate metabolism_Homo sapiens_hsa006500.90252776
64Dopaminergic synapse_Homo sapiens_hsa047280.89009118
65Wnt signaling pathway_Homo sapiens_hsa043100.88092767
66Pathways in cancer_Homo sapiens_hsa052000.88062126
67Long-term depression_Homo sapiens_hsa047300.87457259
68Glutamatergic synapse_Homo sapiens_hsa047240.87391431
69Selenocompound metabolism_Homo sapiens_hsa004500.87271110
70Phototransduction_Homo sapiens_hsa047440.85887386
71DNA replication_Homo sapiens_hsa030300.85686735
72Purine metabolism_Homo sapiens_hsa002300.84958817
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84879721
74Cholinergic synapse_Homo sapiens_hsa047250.84278823
75Base excision repair_Homo sapiens_hsa034100.82795904
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.82642075
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82376166
78Hepatitis B_Homo sapiens_hsa051610.80569446
79cAMP signaling pathway_Homo sapiens_hsa040240.78449873
80Tight junction_Homo sapiens_hsa045300.77333246
81Taste transduction_Homo sapiens_hsa047420.76597500
82ECM-receptor interaction_Homo sapiens_hsa045120.75965076
83Choline metabolism in cancer_Homo sapiens_hsa052310.74487561
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72435564
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71060283
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.69476400
87Insulin secretion_Homo sapiens_hsa049110.69472461
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69378375
89Protein export_Homo sapiens_hsa030600.69098434
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67686119
91Focal adhesion_Homo sapiens_hsa045100.67683293
92Pentose phosphate pathway_Homo sapiens_hsa000300.67641830
93Renin secretion_Homo sapiens_hsa049240.66461454
94Serotonergic synapse_Homo sapiens_hsa047260.65843207
95Antigen processing and presentation_Homo sapiens_hsa046120.64785486
96Lysine degradation_Homo sapiens_hsa003100.64565097
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64451112
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64278654
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63892059
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.63193249
101Influenza A_Homo sapiens_hsa051640.63057796
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62735455
103ErbB signaling pathway_Homo sapiens_hsa040120.62314161
104Melanoma_Homo sapiens_hsa052180.62181098
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61011554
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60953876
107Notch signaling pathway_Homo sapiens_hsa043300.60894271
108Proteoglycans in cancer_Homo sapiens_hsa052050.60890863
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59804551
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.59735230
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59529664
112GABAergic synapse_Homo sapiens_hsa047270.58798085
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57920398
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57636867
115AMPK signaling pathway_Homo sapiens_hsa041520.57193469
116TNF signaling pathway_Homo sapiens_hsa046680.56584393
117Non-small cell lung cancer_Homo sapiens_hsa052230.56542089
118Morphine addiction_Homo sapiens_hsa050320.56021035
119Non-homologous end-joining_Homo sapiens_hsa034500.55982087
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55167809
121Acute myeloid leukemia_Homo sapiens_hsa052210.54098800
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53981984
123MAPK signaling pathway_Homo sapiens_hsa040100.53618383
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52782934
125Apoptosis_Homo sapiens_hsa042100.52700114
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52515884
127Olfactory transduction_Homo sapiens_hsa047400.52356973
128Glucagon signaling pathway_Homo sapiens_hsa049220.51982188
129Inositol phosphate metabolism_Homo sapiens_hsa005620.51742977
130Tryptophan metabolism_Homo sapiens_hsa003800.51241066
131Oxytocin signaling pathway_Homo sapiens_hsa049210.51216805
132Insulin resistance_Homo sapiens_hsa049310.49996201
133Viral myocarditis_Homo sapiens_hsa054160.49682027
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.49537068
135Toxoplasmosis_Homo sapiens_hsa051450.47379837
136Measles_Homo sapiens_hsa051620.47145756
137HIF-1 signaling pathway_Homo sapiens_hsa040660.46314627
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43940829
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40797076
140Sphingolipid metabolism_Homo sapiens_hsa006000.40527361
141Bladder cancer_Homo sapiens_hsa052190.39524681
142Vitamin digestion and absorption_Homo sapiens_hsa049770.38741678
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38507926
144Ras signaling pathway_Homo sapiens_hsa040140.38120795
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37509906
146Estrogen signaling pathway_Homo sapiens_hsa049150.37341302
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36443171
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35762661
149Ovarian steroidogenesis_Homo sapiens_hsa049130.35660799
150Glioma_Homo sapiens_hsa052140.34498362

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