

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pre-miRNA processing (GO:0031054) | 5.60941917 |
| 2 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 5.16391623 |
| 3 | DNA unwinding involved in DNA replication (GO:0006268) | 4.92076915 |
| 4 | negative regulation of RNA splicing (GO:0033119) | 4.62269587 |
| 5 | negative regulation of mRNA processing (GO:0050686) | 4.38878285 |
| 6 | heterochromatin organization (GO:0070828) | 4.14420817 |
| 7 | RNA stabilization (GO:0043489) | 4.03507582 |
| 8 | mRNA stabilization (GO:0048255) | 4.03507582 |
| 9 | peptidyl-arginine omega-N-methylation (GO:0035247) | 4.01947075 |
| 10 | paraxial mesoderm development (GO:0048339) | 3.99613933 |
| 11 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.98404286 |
| 12 | protein localization to kinetochore (GO:0034501) | 3.92143922 |
| 13 | negative regulation of mRNA metabolic process (GO:1903312) | 3.84856468 |
| 14 | establishment of apical/basal cell polarity (GO:0035089) | 3.84001836 |
| 15 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.83355144 |
| 16 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.82652586 |
| 17 | dosage compensation (GO:0007549) | 3.79609910 |
| 18 | regulation of translational fidelity (GO:0006450) | 3.78185571 |
| 19 | peptidyl-lysine dimethylation (GO:0018027) | 3.73143629 |
| 20 | peptidyl-arginine N-methylation (GO:0035246) | 3.66405945 |
| 21 | peptidyl-arginine methylation (GO:0018216) | 3.66405945 |
| 22 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.63846699 |
| 23 | protein-DNA complex disassembly (GO:0032986) | 3.57391246 |
| 24 | nucleosome disassembly (GO:0006337) | 3.57391246 |
| 25 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.56908603 |
| 26 | regulation of sister chromatid cohesion (GO:0007063) | 3.54122796 |
| 27 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.45771169 |
| 28 | polarized epithelial cell differentiation (GO:0030859) | 3.41846004 |
| 29 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.40635173 |
| 30 | regulation of gene silencing by miRNA (GO:0060964) | 3.40635173 |
| 31 | regulation of gene silencing by RNA (GO:0060966) | 3.40635173 |
| 32 | DNA duplex unwinding (GO:0032508) | 3.39113122 |
| 33 | establishment of monopolar cell polarity (GO:0061162) | 3.38845685 |
| 34 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.38845685 |
| 35 | sister chromatid segregation (GO:0000819) | 3.37267863 |
| 36 | positive regulation of RNA splicing (GO:0033120) | 3.37239488 |
| 37 | DNA geometric change (GO:0032392) | 3.35347762 |
| 38 | nuclear pore organization (GO:0006999) | 3.35335610 |
| 39 | intracellular estrogen receptor signaling pathway (GO:0030520) | 3.34606223 |
| 40 | chromatin assembly (GO:0031497) | 3.33950426 |
| 41 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.31157159 |
| 42 | DNA topological change (GO:0006265) | 3.30904762 |
| 43 | regulation of hippo signaling (GO:0035330) | 3.25481728 |
| 44 | regulation of establishment of planar polarity (GO:0090175) | 3.24926844 |
| 45 | protein retention in ER lumen (GO:0006621) | 3.23860695 |
| 46 | regulation of RNA export from nucleus (GO:0046831) | 3.23534071 |
| 47 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 3.23041302 |
| 48 | negative regulation of histone methylation (GO:0031061) | 3.22479875 |
| 49 | histone arginine methylation (GO:0034969) | 3.20943732 |
| 50 | nuclear pore complex assembly (GO:0051292) | 3.18251459 |
| 51 | adherens junction assembly (GO:0034333) | 3.16640885 |
| 52 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.14442939 |
| 53 | regulation of mRNA stability (GO:0043488) | 3.14097467 |
| 54 | protein complex localization (GO:0031503) | 3.13357921 |
| 55 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.11275511 |
| 56 | maternal placenta development (GO:0001893) | 3.11119935 |
| 57 | hippo signaling (GO:0035329) | 3.10150835 |
| 58 | mitotic sister chromatid segregation (GO:0000070) | 3.09312249 |
| 59 | semaphorin-plexin signaling pathway (GO:0071526) | 3.08949867 |
| 60 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.04782812 |
| 61 | regulation of stem cell maintenance (GO:2000036) | 3.04372815 |
| 62 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.04141807 |
| 63 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.04141807 |
| 64 | protein localization to chromosome, centromeric region (GO:0071459) | 3.01637822 |
| 65 | alternative mRNA splicing, via spliceosome (GO:0000380) | 3.00329751 |
| 66 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.98528997 |
| 67 | notochord development (GO:0030903) | 2.97326238 |
| 68 | cell-substrate adherens junction assembly (GO:0007045) | 2.95011016 |
| 69 | focal adhesion assembly (GO:0048041) | 2.95011016 |
| 70 | mitotic nuclear envelope disassembly (GO:0007077) | 2.94741845 |
| 71 | regulation of DNA damage checkpoint (GO:2000001) | 2.94157209 |
| 72 | proximal/distal pattern formation (GO:0009954) | 2.92944109 |
| 73 | cochlea morphogenesis (GO:0090103) | 2.92698396 |
| 74 | regulation of RNA stability (GO:0043487) | 2.92359251 |
| 75 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.88176542 |
| 76 | termination of RNA polymerase II transcription (GO:0006369) | 2.84160198 |
| 77 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.81541945 |
| 78 | mRNA splicing, via spliceosome (GO:0000398) | 2.81541945 |
| 79 | regulation of histone H3-K9 methylation (GO:0051570) | 2.80554322 |
| 80 | apoptotic process involved in morphogenesis (GO:0060561) | 2.79271358 |
| 81 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.79206156 |
| 82 | mRNA splice site selection (GO:0006376) | 2.79063692 |
| 83 | L-serine metabolic process (GO:0006563) | 2.78927628 |
| 84 | neural tube development (GO:0021915) | 2.78466323 |
| 85 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.78385585 |
| 86 | nuclear envelope disassembly (GO:0051081) | 2.78079755 |
| 87 | membrane disassembly (GO:0030397) | 2.78079755 |
| 88 | trophectodermal cell differentiation (GO:0001829) | 2.77779644 |
| 89 | non-canonical Wnt signaling pathway (GO:0035567) | 2.77177383 |
| 90 | RNA splicing, via transesterification reactions (GO:0000375) | 2.76371140 |
| 91 | DNA strand renaturation (GO:0000733) | 2.75226678 |
| 92 | gastrulation with mouth forming second (GO:0001702) | 2.75074160 |
| 93 | regulation of intracellular estrogen receptor signaling pathway (GO:0033146) | 2.73213036 |
| 94 | convergent extension (GO:0060026) | 2.72434418 |
| 95 | mitotic sister chromatid cohesion (GO:0007064) | 2.72299842 |
| 96 | IMP biosynthetic process (GO:0006188) | 2.68976165 |
| 97 | negative regulation of cell size (GO:0045792) | 2.67399653 |
| 98 | DNA replication initiation (GO:0006270) | 2.66532882 |
| 99 | establishment or maintenance of bipolar cell polarity (GO:0061245) | 2.66461928 |
| 100 | establishment or maintenance of apical/basal cell polarity (GO:0035088) | 2.66461928 |
| 101 | pore complex assembly (GO:0046931) | 2.66431016 |
| 102 | regulation of chromatin binding (GO:0035561) | 2.62117809 |
| 103 | cellular response to epidermal growth factor stimulus (GO:0071364) | 2.61061502 |
| 104 | DNA conformation change (GO:0071103) | 2.60916553 |
| 105 | proline metabolic process (GO:0006560) | 2.60289907 |
| 106 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.59854200 |
| 107 | mRNA transport (GO:0051028) | 2.59820091 |
| 108 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.59316410 |
| 109 | establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) | 2.58439340 |
| 110 | histone H2A monoubiquitination (GO:0035518) | 2.58335387 |
| 111 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.58333244 |
| 112 | lateral sprouting from an epithelium (GO:0060601) | 2.58158628 |
| 113 | positive regulation of transcription regulatory region DNA binding (GO:2000679) | 2.58053531 |
| 114 | eye morphogenesis (GO:0048592) | 2.57886451 |
| 115 | stress granule assembly (GO:0034063) | 2.57668302 |
| 116 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.55800195 |
| 117 | establishment of integrated proviral latency (GO:0075713) | 2.55265031 |
| 118 | COPI coating of Golgi vesicle (GO:0048205) | 2.54680444 |
| 119 | Golgi transport vesicle coating (GO:0048200) | 2.54680444 |
| 120 | formation of translation preinitiation complex (GO:0001731) | 2.54639960 |
| 121 | mitotic chromosome condensation (GO:0007076) | 2.54327458 |
| 122 | adenine nucleotide transport (GO:0051503) | 2.53958495 |
| 123 | histone H4-K12 acetylation (GO:0043983) | 2.53789757 |
| 124 | cell-cell junction maintenance (GO:0045217) | 2.53612224 |
| 125 | embryonic foregut morphogenesis (GO:0048617) | 2.53071796 |
| 126 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.52828030 |
| 127 | proline biosynthetic process (GO:0006561) | 2.52488434 |
| 128 | anatomical structure regression (GO:0060033) | 2.52226497 |
| 129 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.52195380 |
| 130 | cellular protein complex localization (GO:0034629) | 2.51997012 |
| 131 | positive regulation of chromosome segregation (GO:0051984) | 2.51321351 |
| 132 | chromosome condensation (GO:0030261) | 2.51250097 |
| 133 | RNA export from nucleus (GO:0006405) | 2.50357561 |
| 134 | DNA strand elongation (GO:0022616) | 2.49912446 |
| 135 | negative regulation of glial cell proliferation (GO:0060253) | 2.49823100 |
| 136 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.47989178 |
| 137 | corticosteroid receptor signaling pathway (GO:0031958) | 2.47945955 |
| 138 | head development (GO:0060322) | 2.47893026 |
| 139 | cell migration in hindbrain (GO:0021535) | 2.47627922 |
| 140 | embryonic eye morphogenesis (GO:0048048) | 2.46135274 |
| 141 | chromatin silencing (GO:0006342) | 2.45586487 |
| 142 | basement membrane organization (GO:0071711) | 2.40496532 |
| 143 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 2.37517493 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.47985146 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.54679171 |
| 3 | MYC_22102868_ChIP-Seq_BL_Human | 3.54053589 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.89940134 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.87354213 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.79606154 |
| 7 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.75807298 |
| 8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.59154278 |
| 9 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.51122647 |
| 10 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.42854112 |
| 11 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.42507776 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.36912963 |
| 13 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.20305593 |
| 14 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.20079228 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.17325191 |
| 16 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.06162906 |
| 17 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.95893694 |
| 18 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.95085838 |
| 19 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.95061477 |
| 20 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.92807732 |
| 21 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.88362976 |
| 22 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.83771784 |
| 23 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.81389072 |
| 24 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.80523131 |
| 25 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.79190474 |
| 26 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.74423749 |
| 27 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.74277224 |
| 28 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.73415435 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.72888333 |
| 30 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.72005489 |
| 31 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.71079069 |
| 32 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.70133470 |
| 33 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.69557604 |
| 34 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.68138151 |
| 35 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.63911561 |
| 36 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.63040847 |
| 37 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.60355869 |
| 38 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.59360616 |
| 39 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.59360616 |
| 40 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.59360616 |
| 41 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.59203490 |
| 42 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.57835420 |
| 43 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.54755624 |
| 44 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.53974796 |
| 45 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.52448237 |
| 46 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.52067840 |
| 47 | P68_20966046_ChIP-Seq_HELA_Human | 1.50843623 |
| 48 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.50715582 |
| 49 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.49943707 |
| 50 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.49806255 |
| 51 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.45701938 |
| 52 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.45100974 |
| 53 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.43519873 |
| 54 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.42467008 |
| 55 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.41975780 |
| 56 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.41284273 |
| 57 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.41118589 |
| 58 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.40916129 |
| 59 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.38770471 |
| 60 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.37282811 |
| 61 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.36778542 |
| 62 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.36259766 |
| 63 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.36024170 |
| 64 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.35992994 |
| 65 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.35307888 |
| 66 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35073554 |
| 67 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.34129771 |
| 68 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.32756604 |
| 69 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.31838101 |
| 70 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.31754051 |
| 71 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.31560481 |
| 72 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.30971152 |
| 73 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.29991247 |
| 74 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.29819843 |
| 75 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.29663404 |
| 76 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.27751266 |
| 77 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.25501347 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.25266219 |
| 79 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.25143726 |
| 80 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.24362038 |
| 81 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.24109162 |
| 82 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.24014941 |
| 83 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.23965575 |
| 84 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.22828511 |
| 85 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.21578891 |
| 86 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.21488277 |
| 87 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.19039536 |
| 88 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.18922318 |
| 89 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.18816753 |
| 90 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.18560597 |
| 91 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.17900591 |
| 92 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.17020560 |
| 93 | KDM2B_26808549_Chip-Seq_K562_Human | 1.16470498 |
| 94 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.16326667 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.15785758 |
| 96 | MAF_26560356_Chip-Seq_TH1_Human | 1.14472968 |
| 97 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.14025554 |
| 98 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.13412137 |
| 99 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.13306761 |
| 100 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.13173758 |
| 101 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.13101029 |
| 102 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.12313384 |
| 103 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.12300169 |
| 104 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.11678369 |
| 105 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.11426488 |
| 106 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.10635393 |
| 107 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.10121062 |
| 108 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.09881549 |
| 109 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.09402141 |
| 110 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.08026313 |
| 111 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.07695303 |
| 112 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.07496258 |
| 113 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07275463 |
| 114 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.06270812 |
| 115 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.06141533 |
| 116 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.05459683 |
| 117 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.04081457 |
| 118 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.03864332 |
| 119 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.03805030 |
| 120 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.03600062 |
| 121 | ATF3_27146783_Chip-Seq_COLON_Human | 1.03258734 |
| 122 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.03043891 |
| 123 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.02952701 |
| 124 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.00583924 |
| 125 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.00062270 |
| 126 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.99501701 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000537_abnormal_urethra_morphology | 3.46179000 |
| 2 | MP0010030_abnormal_orbit_morphology | 3.28525305 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 3.04101329 |
| 4 | MP0005076_abnormal_cell_differentiation | 2.70905423 |
| 5 | MP0003123_paternal_imprinting | 2.60518714 |
| 6 | MP0009053_abnormal_anal_canal | 2.55599050 |
| 7 | MP0002653_abnormal_ependyma_morphology | 2.48434839 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.45963898 |
| 9 | MP0009278_abnormal_bone_marrow | 2.38497105 |
| 10 | MP0010352_gastrointestinal_tract_polyps | 2.29447215 |
| 11 | MP0008057_abnormal_DNA_replication | 2.23619902 |
| 12 | MP0004957_abnormal_blastocyst_morpholog | 2.16565845 |
| 13 | MP0003077_abnormal_cell_cycle | 2.14219106 |
| 14 | MP0005257_abnormal_intraocular_pressure | 2.13717774 |
| 15 | MP0004197_abnormal_fetal_growth/weight/ | 2.13406658 |
| 16 | MP0010094_abnormal_chromosome_stability | 2.09873448 |
| 17 | MP0000566_synostosis | 2.07921866 |
| 18 | MP0003119_abnormal_digestive_system | 2.06473262 |
| 19 | MP0003567_abnormal_fetal_cardiomyocyte | 2.04544512 |
| 20 | MP0002084_abnormal_developmental_patter | 2.01874614 |
| 21 | MP0005409_darkened_coat_color | 1.97003515 |
| 22 | MP0002085_abnormal_embryonic_tissue | 1.93314509 |
| 23 | MP0001730_embryonic_growth_arrest | 1.90869915 |
| 24 | MP0003121_genomic_imprinting | 1.87091346 |
| 25 | MP0003890_abnormal_embryonic-extraembry | 1.85010276 |
| 26 | MP0001672_abnormal_embryogenesis/_devel | 1.81548994 |
| 27 | MP0005380_embryogenesis_phenotype | 1.81548994 |
| 28 | MP0001849_ear_inflammation | 1.78233414 |
| 29 | MP0004233_abnormal_muscle_weight | 1.76337839 |
| 30 | MP0000350_abnormal_cell_proliferation | 1.74798887 |
| 31 | MP0001697_abnormal_embryo_size | 1.68543330 |
| 32 | MP0003385_abnormal_body_wall | 1.67914510 |
| 33 | MP0001293_anophthalmia | 1.67684953 |
| 34 | MP0002249_abnormal_larynx_morphology | 1.67397029 |
| 35 | MP0003984_embryonic_growth_retardation | 1.65813952 |
| 36 | MP0002088_abnormal_embryonic_growth/wei | 1.65646989 |
| 37 | MP0003283_abnormal_digestive_organ | 1.65111724 |
| 38 | MP0003122_maternal_imprinting | 1.64902075 |
| 39 | MP0002086_abnormal_extraembryonic_tissu | 1.64399588 |
| 40 | MP0000428_abnormal_craniofacial_morphol | 1.62107654 |
| 41 | MP0000733_abnormal_muscle_development | 1.61258573 |
| 42 | MP0003693_abnormal_embryo_hatching | 1.57262962 |
| 43 | MP0000049_abnormal_middle_ear | 1.57188512 |
| 44 | MP0003942_abnormal_urinary_system | 1.56132601 |
| 45 | MP0002932_abnormal_joint_morphology | 1.53818970 |
| 46 | MP0001346_abnormal_lacrimal_gland | 1.51502760 |
| 47 | MP0002697_abnormal_eye_size | 1.50719236 |
| 48 | MP0002282_abnormal_trachea_morphology | 1.50527940 |
| 49 | MP0003935_abnormal_craniofacial_develop | 1.47419596 |
| 50 | MP0005187_abnormal_penis_morphology | 1.46487308 |
| 51 | MP0002092_abnormal_eye_morphology | 1.46115297 |
| 52 | MP0003115_abnormal_respiratory_system | 1.44127308 |
| 53 | MP0002080_prenatal_lethality | 1.44024872 |
| 54 | MP0008007_abnormal_cellular_replicative | 1.43727803 |
| 55 | MP0005171_absent_coat_pigmentation | 1.41700581 |
| 56 | MP0002254_reproductive_system_inflammat | 1.37762335 |
| 57 | MP0005623_abnormal_meninges_morphology | 1.37300231 |
| 58 | MP0003937_abnormal_limbs/digits/tail_de | 1.33958562 |
| 59 | MP0004272_abnormal_basement_membrane | 1.33559930 |
| 60 | MP0009672_abnormal_birth_weight | 1.30470736 |
| 61 | MP0002111_abnormal_tail_morphology | 1.30253409 |
| 62 | MP0000534_abnormal_ureter_morphology | 1.29996164 |
| 63 | MP0001661_extended_life_span | 1.29178771 |
| 64 | MP0003861_abnormal_nervous_system | 1.29118882 |
| 65 | MP0003136_yellow_coat_color | 1.29065564 |
| 66 | MP0008932_abnormal_embryonic_tissue | 1.25228391 |
| 67 | MP0010307_abnormal_tumor_latency | 1.23225266 |
| 68 | MP0002116_abnormal_craniofacial_bone | 1.21035789 |
| 69 | MP0003755_abnormal_palate_morphology | 1.20667389 |
| 70 | MP0010234_abnormal_vibrissa_follicle | 1.19675808 |
| 71 | MP0009703_decreased_birth_body | 1.19512768 |
| 72 | MP0000003_abnormal_adipose_tissue | 1.18530982 |
| 73 | MP0005248_abnormal_Harderian_gland | 1.14283869 |
| 74 | MP0002396_abnormal_hematopoietic_system | 1.13935239 |
| 75 | MP0003453_abnormal_keratinocyte_physiol | 1.13464942 |
| 76 | MP0005501_abnormal_skin_physiology | 1.13214223 |
| 77 | MP0000751_myopathy | 1.12931995 |
| 78 | MP0002925_abnormal_cardiovascular_devel | 1.12145550 |
| 79 | MP0001915_intracranial_hemorrhage | 1.11433029 |
| 80 | MP0000432_abnormal_head_morphology | 1.09708919 |
| 81 | MP0001299_abnormal_eye_distance/ | 1.08930007 |
| 82 | MP0004808_abnormal_hematopoietic_stem | 1.08534453 |
| 83 | MP0001348_abnormal_lacrimal_gland | 1.06909503 |
| 84 | MP0002114_abnormal_axial_skeleton | 1.06541487 |
| 85 | MP0005423_abnormal_somatic_nervous | 1.06415600 |
| 86 | MP0002938_white_spotting | 1.05809942 |
| 87 | MP0000762_abnormal_tongue_morphology | 1.04458359 |
| 88 | MP0003315_abnormal_perineum_morphology | 1.03388225 |
| 89 | MP0010630_abnormal_cardiac_muscle | 1.02978825 |
| 90 | MP0001286_abnormal_eye_development | 0.98190019 |
| 91 | MP0004264_abnormal_extraembryonic_tissu | 0.97477987 |
| 92 | MP0005367_renal/urinary_system_phenotyp | 0.97472317 |
| 93 | MP0000516_abnormal_urinary_system | 0.97472317 |
| 94 | MP0006054_spinal_hemorrhage | 0.97278855 |
| 95 | MP0008438_abnormal_cutaneous_collagen | 0.96850587 |
| 96 | MP0000490_abnormal_crypts_of | 0.96080480 |
| 97 | MP0002009_preneoplasia | 0.95610626 |
| 98 | MP0008770_decreased_survivor_rate | 0.95342328 |
| 99 | MP0003566_abnormal_cell_adhesion | 0.94305537 |
| 100 | MP0002081_perinatal_lethality | 0.93748677 |
| 101 | MP0000462_abnormal_digestive_system | 0.93203997 |
| 102 | MP0006292_abnormal_olfactory_placode | 0.93167744 |
| 103 | MP0000569_abnormal_digit_pigmentation | 0.92715065 |
| 104 | MP0005666_abnormal_adipose_tissue | 0.92312124 |
| 105 | MP0002233_abnormal_nose_morphology | 0.90810869 |
| 106 | MP0005375_adipose_tissue_phenotype | 0.87827812 |
| 107 | MP0000266_abnormal_heart_morphology | 0.87354225 |
| 108 | MP0003938_abnormal_ear_development | 0.86901470 |
| 109 | MP0008789_abnormal_olfactory_epithelium | 0.86614773 |
| 110 | MP0000313_abnormal_cell_death | 0.85964612 |
| 111 | MP0009384_cardiac_valve_regurgitation | 0.85842694 |
| 112 | MP0002089_abnormal_postnatal_growth/wei | 0.85222138 |
| 113 | MP0000778_abnormal_nervous_system | 0.84983849 |
| 114 | MP0009250_abnormal_appendicular_skeleto | 0.84102525 |
| 115 | MP0001188_hyperpigmentation | 0.83039930 |
| 116 | MP0005397_hematopoietic_system_phenotyp | 0.82906601 |
| 117 | MP0001545_abnormal_hematopoietic_system | 0.82906601 |
| 118 | MP0005451_abnormal_body_composition | 0.82533380 |
| 119 | MP0001340_abnormal_eyelid_morphology | 0.82121771 |
| 120 | MP0000678_abnormal_parathyroid_gland | 0.82118123 |
| 121 | MP0003091_abnormal_cell_migration | 0.81674004 |
| 122 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81286248 |
| 123 | MP0004185_abnormal_adipocyte_glucose | 0.79662651 |
| 124 | MP0002234_abnormal_pharynx_morphology | 0.78889293 |
| 125 | MP0002751_abnormal_autonomic_nervous | 0.76779481 |
| 126 | MP0004133_heterotaxia | 0.76407084 |
| 127 | MP0002877_abnormal_melanocyte_morpholog | 0.75982646 |
| 128 | MP0004858_abnormal_nervous_system | 0.75782619 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 4.07562075 |
| 2 | Short 4th metacarpal (HP:0010044) | 4.07562075 |
| 3 | Renal duplication (HP:0000075) | 4.04534892 |
| 4 | Hyperacusis (HP:0010780) | 3.99311957 |
| 5 | Abnormality of the 4th metacarpal (HP:0010012) | 3.59990668 |
| 6 | Ependymoma (HP:0002888) | 3.30047216 |
| 7 | Elfin facies (HP:0004428) | 3.03273683 |
| 8 | Increased nuchal translucency (HP:0010880) | 3.00938580 |
| 9 | Astrocytoma (HP:0009592) | 2.99366354 |
| 10 | Abnormality of the astrocytes (HP:0100707) | 2.99366354 |
| 11 | Renovascular hypertension (HP:0100817) | 2.97540769 |
| 12 | Shallow orbits (HP:0000586) | 2.91115011 |
| 13 | Overriding aorta (HP:0002623) | 2.85048142 |
| 14 | Rib fusion (HP:0000902) | 2.83033041 |
| 15 | Pseudobulbar signs (HP:0002200) | 2.82849467 |
| 16 | Thin ribs (HP:0000883) | 2.66652266 |
| 17 | Intestinal fistula (HP:0100819) | 2.64625161 |
| 18 | Selective tooth agenesis (HP:0001592) | 2.63535559 |
| 19 | Ulnar bowing (HP:0003031) | 2.61336165 |
| 20 | Choanal stenosis (HP:0000452) | 2.57167004 |
| 21 | Insomnia (HP:0100785) | 2.53484252 |
| 22 | Vaginal fistula (HP:0004320) | 2.53091823 |
| 23 | Medulloblastoma (HP:0002885) | 2.42198058 |
| 24 | Colon cancer (HP:0003003) | 2.38628222 |
| 25 | Abnormality of the diencephalon (HP:0010662) | 2.37449771 |
| 26 | Disproportionate tall stature (HP:0001519) | 2.36992790 |
| 27 | Abnormal number of incisors (HP:0011064) | 2.36549896 |
| 28 | Rectal fistula (HP:0100590) | 2.34109487 |
| 29 | Rectovaginal fistula (HP:0000143) | 2.34109487 |
| 30 | Short 5th finger (HP:0009237) | 2.31042673 |
| 31 | Flat cornea (HP:0007720) | 2.29395073 |
| 32 | Cerebral aneurysm (HP:0004944) | 2.28775271 |
| 33 | Facial hemangioma (HP:0000329) | 2.28575154 |
| 34 | Bowel diverticulosis (HP:0005222) | 2.28432138 |
| 35 | Cortical dysplasia (HP:0002539) | 2.26649619 |
| 36 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.26641172 |
| 37 | Lymphangioma (HP:0100764) | 2.25275679 |
| 38 | Thin bony cortex (HP:0002753) | 2.18891412 |
| 39 | Long palpebral fissure (HP:0000637) | 2.18674990 |
| 40 | Neoplasm of striated muscle (HP:0009728) | 2.17005057 |
| 41 | Broad face (HP:0000283) | 2.16484111 |
| 42 | Abnormality of the lower motor neuron (HP:0002366) | 2.16347326 |
| 43 | Glioma (HP:0009733) | 2.16056575 |
| 44 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.15936875 |
| 45 | Turricephaly (HP:0000262) | 2.15906447 |
| 46 | Broad distal phalanx of finger (HP:0009836) | 2.15787405 |
| 47 | Broad thumb (HP:0011304) | 2.15473829 |
| 48 | Partial duplication of thumb phalanx (HP:0009944) | 2.14286415 |
| 49 | Biconcave vertebral bodies (HP:0004586) | 2.13887675 |
| 50 | Bronchomalacia (HP:0002780) | 2.13870184 |
| 51 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.13009622 |
| 52 | Proximal placement of thumb (HP:0009623) | 2.11997519 |
| 53 | Coronal craniosynostosis (HP:0004440) | 2.11839461 |
| 54 | Deviation of the hallux (HP:0010051) | 2.09135869 |
| 55 | Pointed chin (HP:0000307) | 2.09121163 |
| 56 | Deviation of the thumb (HP:0009603) | 2.07557880 |
| 57 | Partial duplication of the phalanx of hand (HP:0009999) | 2.07167713 |
| 58 | High anterior hairline (HP:0009890) | 2.05987503 |
| 59 | Hallux valgus (HP:0001822) | 2.04671621 |
| 60 | Skin tags (HP:0010609) | 2.04105971 |
| 61 | Spina bifida occulta (HP:0003298) | 2.04064241 |
| 62 | Subacute progressive viral hepatitis (HP:0006572) | 2.03467244 |
| 63 | Dysmetric saccades (HP:0000641) | 2.03016368 |
| 64 | Volvulus (HP:0002580) | 2.02265278 |
| 65 | Genu recurvatum (HP:0002816) | 2.02040463 |
| 66 | Premature rupture of membranes (HP:0001788) | 2.00928701 |
| 67 | Megalocornea (HP:0000485) | 2.00659664 |
| 68 | Increased density of long bones (HP:0006392) | 2.00137340 |
| 69 | Annular pancreas (HP:0001734) | 1.99150507 |
| 70 | Short phalanx of the thumb (HP:0009660) | 1.98737872 |
| 71 | Supernumerary ribs (HP:0005815) | 1.96452614 |
| 72 | Atresia of the external auditory canal (HP:0000413) | 1.95968042 |
| 73 | Macroorchidism (HP:0000053) | 1.95771977 |
| 74 | Heterotopia (HP:0002282) | 1.95138807 |
| 75 | Bladder diverticulum (HP:0000015) | 1.94446393 |
| 76 | Abnormality of the calcaneus (HP:0008364) | 1.94055295 |
| 77 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.93385605 |
| 78 | Gastrointestinal carcinoma (HP:0002672) | 1.93385605 |
| 79 | Urethral obstruction (HP:0000796) | 1.92652086 |
| 80 | Fibroma (HP:0010614) | 1.92310611 |
| 81 | Neoplasm of the oral cavity (HP:0100649) | 1.92070315 |
| 82 | Abnormality of the fingertips (HP:0001211) | 1.91305977 |
| 83 | Spastic diplegia (HP:0001264) | 1.91145436 |
| 84 | Missing ribs (HP:0000921) | 1.90152333 |
| 85 | Hepatoblastoma (HP:0002884) | 1.89919124 |
| 86 | Fibrous tissue neoplasm (HP:0012316) | 1.89406235 |
| 87 | Obsessive-compulsive behavior (HP:0000722) | 1.88117013 |
| 88 | Intestinal polyp (HP:0005266) | 1.87959325 |
| 89 | Sacral dimple (HP:0000960) | 1.87684680 |
| 90 | Obstructive sleep apnea (HP:0002870) | 1.87489701 |
| 91 | Short 1st metacarpal (HP:0010034) | 1.86151160 |
| 92 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.86151160 |
| 93 | Broad palm (HP:0001169) | 1.85874598 |
| 94 | Enlarged penis (HP:0000040) | 1.85587648 |
| 95 | Vertebral fusion (HP:0002948) | 1.84816100 |
| 96 | Preauricular skin tag (HP:0000384) | 1.84668952 |
| 97 | Trigonocephaly (HP:0000243) | 1.82227640 |
| 98 | Duplication of thumb phalanx (HP:0009942) | 1.81532421 |
| 99 | Broad finger (HP:0001500) | 1.80680226 |
| 100 | Spinal cord lesions (HP:0100561) | 1.80090083 |
| 101 | Syringomyelia (HP:0003396) | 1.80090083 |
| 102 | Patellar aplasia (HP:0006443) | 1.79986538 |
| 103 | Long eyelashes (HP:0000527) | 1.79385368 |
| 104 | Rhabdomyosarcoma (HP:0002859) | 1.78946468 |
| 105 | Shawl scrotum (HP:0000049) | 1.78679225 |
| 106 | Rectal prolapse (HP:0002035) | 1.76905616 |
| 107 | Protrusio acetabuli (HP:0003179) | 1.76856702 |
| 108 | Broad alveolar ridges (HP:0000187) | 1.76455563 |
| 109 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.76156195 |
| 110 | Flat acetabular roof (HP:0003180) | 1.75093928 |
| 111 | Intestinal polyposis (HP:0200008) | 1.75008667 |
| 112 | Basal cell carcinoma (HP:0002671) | 1.74932872 |
| 113 | Abnormality of the aortic arch (HP:0012303) | 1.74827516 |
| 114 | Midface retrusion (HP:0011800) | 1.72996665 |
| 115 | Broad metatarsal (HP:0001783) | 1.72493890 |
| 116 | Bowed forearm bones (HP:0003956) | 1.72138228 |
| 117 | Bowing of the arm (HP:0006488) | 1.72138228 |
| 118 | Capillary hemangiomas (HP:0005306) | 1.71894387 |
| 119 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.71819324 |
| 120 | Germ cell neoplasia (HP:0100728) | 1.71787505 |
| 121 | Broad phalanges of the hand (HP:0009768) | 1.71468191 |
| 122 | Asymmetry of the thorax (HP:0001555) | 1.71447493 |
| 123 | Aplasia involving bones of the extremities (HP:0009825) | 1.71265681 |
| 124 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.71265681 |
| 125 | Aplasia of the phalanges of the hand (HP:0009802) | 1.71265681 |
| 126 | Patellar dislocation (HP:0002999) | 1.70576560 |
| 127 | Skull defect (HP:0001362) | 1.70458468 |
| 128 | Anteriorly placed anus (HP:0001545) | 1.69923105 |
| 129 | Uterine leiomyosarcoma (HP:0002891) | 1.69728286 |
| 130 | Leiomyosarcoma (HP:0100243) | 1.69728286 |
| 131 | Neoplasm of the heart (HP:0100544) | 1.69705749 |
| 132 | Arnold-Chiari malformation (HP:0002308) | 1.69195539 |
| 133 | Abnormality of the labia minora (HP:0012880) | 1.68787523 |
| 134 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.68531203 |
| 135 | Back pain (HP:0003418) | 1.67892194 |
| 136 | Angiofibromas (HP:0010615) | 1.66653751 |
| 137 | Poikiloderma (HP:0001029) | 1.66035952 |
| 138 | Hemorrhage of the eye (HP:0011885) | 1.65802147 |
| 139 | Broad long bones (HP:0005622) | 1.65688732 |
| 140 | Dislocated radial head (HP:0003083) | 1.64772494 |
| 141 | Morphological abnormality of the middle ear (HP:0008609) | 1.63652086 |
| 142 | Absent epiphyses (HP:0010577) | 1.63626759 |
| 143 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.63626759 |
| 144 | Testicular atrophy (HP:0000029) | 1.63067220 |
| 145 | Broad phalanx (HP:0006009) | 1.63051109 |
| 146 | Pterygium (HP:0001059) | 1.61766721 |
| 147 | Vertebral arch anomaly (HP:0008438) | 1.60515755 |
| 148 | Squamous cell carcinoma (HP:0002860) | 1.60431436 |
| 149 | Precocious puberty (HP:0000826) | 1.60270262 |
| 150 | Metaphyseal cupping (HP:0003021) | 1.59606628 |
| 151 | Neonatal short-limb short stature (HP:0008921) | 1.56878651 |
| 152 | Mitral regurgitation (HP:0001653) | 1.55779278 |
| 153 | Abnormality of the radial head (HP:0003995) | 1.54913512 |
| 154 | Deep palmar crease (HP:0006191) | 1.54665791 |
| 155 | Generalized hypotonia (HP:0001290) | 1.53740074 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K10 | 4.39553979 |
| 2 | EEF2K | 4.23985206 |
| 3 | SMG1 | 3.85608996 |
| 4 | PKN2 | 3.63066217 |
| 5 | TRIB3 | 3.54796053 |
| 6 | CDK12 | 3.11959486 |
| 7 | ICK | 3.11250288 |
| 8 | CDC7 | 2.48474569 |
| 9 | NEK2 | 2.08779938 |
| 10 | PDGFRA | 2.08509082 |
| 11 | EPHB2 | 1.88952095 |
| 12 | FGFR4 | 1.88946163 |
| 13 | DDR2 | 1.84540228 |
| 14 | RPS6KB2 | 1.82735175 |
| 15 | LATS2 | 1.76572487 |
| 16 | LATS1 | 1.73846170 |
| 17 | PTK6 | 1.69259680 |
| 18 | ALK | 1.68512432 |
| 19 | MKNK1 | 1.63259627 |
| 20 | TYRO3 | 1.60496406 |
| 21 | PASK | 1.57813184 |
| 22 | CDK6 | 1.53536146 |
| 23 | RIPK1 | 1.49588664 |
| 24 | PAK4 | 1.47147675 |
| 25 | TTN | 1.43262545 |
| 26 | NTRK1 | 1.42297056 |
| 27 | BMX | 1.42023723 |
| 28 | MTOR | 1.41884333 |
| 29 | CDK4 | 1.40720114 |
| 30 | PRPF4B | 1.35447878 |
| 31 | SIK2 | 1.31147462 |
| 32 | EPHA2 | 1.26622033 |
| 33 | IRAK3 | 1.25911967 |
| 34 | CDK7 | 1.22032329 |
| 35 | TGFBR1 | 1.20449026 |
| 36 | NEK1 | 1.19632151 |
| 37 | MAPK15 | 1.15624207 |
| 38 | FGFR2 | 1.11597654 |
| 39 | DYRK1B | 1.10918097 |
| 40 | MKNK2 | 1.06787319 |
| 41 | LRRK2 | 1.05084155 |
| 42 | TTK | 1.03178921 |
| 43 | UHMK1 | 1.01270227 |
| 44 | TSSK6 | 0.97723642 |
| 45 | PAK2 | 0.96754464 |
| 46 | SIK1 | 0.96458823 |
| 47 | ATR | 0.92363797 |
| 48 | MATK | 0.92084099 |
| 49 | CHEK1 | 0.91942413 |
| 50 | GRK6 | 0.89349536 |
| 51 | DYRK3 | 0.87759311 |
| 52 | STK3 | 0.86967773 |
| 53 | MAP3K8 | 0.86845607 |
| 54 | SCYL2 | 0.86714602 |
| 55 | FGFR1 | 0.86144184 |
| 56 | TAF1 | 0.84756707 |
| 57 | BRD4 | 0.83698983 |
| 58 | VRK2 | 0.83338611 |
| 59 | ERBB2 | 0.82070312 |
| 60 | FLT3 | 0.81633836 |
| 61 | ILK | 0.81070480 |
| 62 | CDK2 | 0.80763430 |
| 63 | MAP3K6 | 0.80687141 |
| 64 | MAP2K2 | 0.79889371 |
| 65 | NME2 | 0.79838011 |
| 66 | STK10 | 0.78808699 |
| 67 | ERN1 | 0.78595551 |
| 68 | PLK1 | 0.77725997 |
| 69 | RPS6KC1 | 0.73177654 |
| 70 | RPS6KL1 | 0.73177654 |
| 71 | CDK11A | 0.72626281 |
| 72 | AURKA | 0.70653768 |
| 73 | MARK2 | 0.70578417 |
| 74 | CDK15 | 0.70555990 |
| 75 | WEE1 | 0.70287177 |
| 76 | MAP3K9 | 0.69574569 |
| 77 | BRAF | 0.68980403 |
| 78 | CHEK2 | 0.68946603 |
| 79 | TAOK1 | 0.68172716 |
| 80 | AKT2 | 0.67792481 |
| 81 | RPS6KA1 | 0.64941523 |
| 82 | MARK1 | 0.64644706 |
| 83 | CDK18 | 0.64459870 |
| 84 | PDGFRB | 0.63821709 |
| 85 | KSR1 | 0.62772397 |
| 86 | ERBB3 | 0.62532623 |
| 87 | ATM | 0.61478427 |
| 88 | KSR2 | 0.60597759 |
| 89 | BUB1 | 0.58975433 |
| 90 | HIPK2 | 0.58752086 |
| 91 | AURKB | 0.58711598 |
| 92 | RPS6KA6 | 0.58518040 |
| 93 | PTK2 | 0.57847677 |
| 94 | PRKD3 | 0.56718474 |
| 95 | CDK1 | 0.55397436 |
| 96 | FGR | 0.55193408 |
| 97 | PIM1 | 0.54239496 |
| 98 | PRKD2 | 0.53442429 |
| 99 | IRAK2 | 0.51868978 |
| 100 | SRPK1 | 0.51196086 |
| 101 | CSNK1E | 0.50928122 |
| 102 | WNK1 | 0.50413227 |
| 103 | CAMK1G | 0.50219249 |
| 104 | CAMK1D | 0.49281206 |
| 105 | CDC42BPA | 0.48854415 |
| 106 | CDK14 | 0.47258064 |
| 107 | RPS6KA2 | 0.46592228 |
| 108 | DMPK | 0.46075802 |
| 109 | ARAF | 0.45907798 |
| 110 | MAPK11 | 0.45651998 |
| 111 | CDK9 | 0.44454163 |
| 112 | MAP3K11 | 0.43816043 |
| 113 | TESK2 | 0.43753182 |
| 114 | CSNK1A1L | 0.43503435 |
| 115 | MET | 0.43122361 |
| 116 | PDPK1 | 0.43067403 |
| 117 | AKT1 | 0.42533955 |
| 118 | CSNK1D | 0.42389742 |
| 119 | MAPK14 | 0.42321811 |
| 120 | GSK3B | 0.41303246 |
| 121 | CDK8 | 0.41247415 |
| 122 | CLK1 | 0.40742375 |
| 123 | RPS6KA4 | 0.40706759 |
| 124 | STK4 | 0.39644450 |
| 125 | GSK3A | 0.39256133 |
| 126 | PRKDC | 0.39076479 |
| 127 | MAPK10 | 0.38576991 |
| 128 | MAPK9 | 0.37246136 |
| 129 | MAPK1 | 0.36925832 |
| 130 | RET | 0.34739608 |
| 131 | CSK | 0.34693355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 2.92672845 |
| 2 | Spliceosome_Homo sapiens_hsa03040 | 2.90946349 |
| 3 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.55732900 |
| 4 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.52309656 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.49580837 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.35259969 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 2.34435787 |
| 8 | Notch signaling pathway_Homo sapiens_hsa04330 | 2.22924320 |
| 9 | Cell cycle_Homo sapiens_hsa04110 | 2.19399472 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.16319567 |
| 11 | Hippo signaling pathway_Homo sapiens_hsa04390 | 2.05339401 |
| 12 | Lysine degradation_Homo sapiens_hsa00310 | 2.03169489 |
| 13 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.95506484 |
| 14 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.91477650 |
| 15 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.87752783 |
| 16 | Colorectal cancer_Homo sapiens_hsa05210 | 1.73393976 |
| 17 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.73253656 |
| 18 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.68691741 |
| 19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.67139286 |
| 20 | Endometrial cancer_Homo sapiens_hsa05213 | 1.56791356 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.51657683 |
| 22 | Adherens junction_Homo sapiens_hsa04520 | 1.49426769 |
| 23 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.48230749 |
| 24 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.45407228 |
| 25 | Bladder cancer_Homo sapiens_hsa05219 | 1.39427450 |
| 26 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.37754662 |
| 27 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.37597937 |
| 28 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.34992684 |
| 29 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.34521328 |
| 30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.33832083 |
| 31 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.32270743 |
| 32 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.32121422 |
| 33 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.30694689 |
| 34 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.29091376 |
| 35 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.29000490 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 1.28406246 |
| 37 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.26035379 |
| 38 | HTLV-I infection_Homo sapiens_hsa05166 | 1.24066146 |
| 39 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.22492729 |
| 40 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.22272572 |
| 41 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.20741577 |
| 42 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.20107376 |
| 43 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.16172614 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.14845501 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.07622926 |
| 46 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.07562077 |
| 47 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.02842424 |
| 48 | Ribosome_Homo sapiens_hsa03010 | 1.01560330 |
| 49 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.01272756 |
| 50 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.00788319 |
| 51 | Prion diseases_Homo sapiens_hsa05020 | 0.99663856 |
| 52 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.99548008 |
| 53 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.97497651 |
| 54 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.97438394 |
| 55 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.95515450 |
| 56 | Pathways in cancer_Homo sapiens_hsa05200 | 0.94586789 |
| 57 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.94409666 |
| 58 | RNA degradation_Homo sapiens_hsa03018 | 0.93923496 |
| 59 | Focal adhesion_Homo sapiens_hsa04510 | 0.93296647 |
| 60 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.91978267 |
| 61 | Tight junction_Homo sapiens_hsa04530 | 0.91065075 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.90034825 |
| 63 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.89883313 |
| 64 | Glioma_Homo sapiens_hsa05214 | 0.86353590 |
| 65 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.85728867 |
| 66 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.83890965 |
| 67 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.83170656 |
| 68 | Homologous recombination_Homo sapiens_hsa03440 | 0.79643361 |
| 69 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.78611661 |
| 70 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.78117852 |
| 71 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.77553828 |
| 72 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.77201688 |
| 73 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.77004983 |
| 74 | Prostate cancer_Homo sapiens_hsa05215 | 0.75131939 |
| 75 | Axon guidance_Homo sapiens_hsa04360 | 0.73369710 |
| 76 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.73267493 |
| 77 | Galactose metabolism_Homo sapiens_hsa00052 | 0.71461677 |
| 78 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.70444780 |
| 79 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68468316 |
| 80 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67736492 |
| 81 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.67341383 |
| 82 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.67277205 |
| 83 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.66265509 |
| 84 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.65996595 |
| 85 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65281915 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.64590331 |
| 87 | Other glycan degradation_Homo sapiens_hsa00511 | 0.64515934 |
| 88 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.64248192 |
| 89 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.63541016 |
| 90 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.63041417 |
| 91 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.62896760 |
| 92 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62698517 |
| 93 | Melanogenesis_Homo sapiens_hsa04916 | 0.62570454 |
| 94 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.62175987 |
| 95 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.61675993 |
| 96 | Hepatitis B_Homo sapiens_hsa05161 | 0.61380606 |
| 97 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.59730393 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.59239388 |
| 99 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.58831265 |
| 100 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.55837859 |
| 101 | Melanoma_Homo sapiens_hsa05218 | 0.55486087 |
| 102 | Apoptosis_Homo sapiens_hsa04210 | 0.54620134 |
| 103 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.54580915 |
| 104 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.54514354 |
| 105 | Gap junction_Homo sapiens_hsa04540 | 0.52502022 |
| 106 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.51803987 |
| 107 | Alcoholism_Homo sapiens_hsa05034 | 0.51032302 |
| 108 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.50764587 |
| 109 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.50010463 |
| 110 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.49842476 |
| 111 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.49729318 |
| 112 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49489022 |
| 113 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.48009756 |
| 114 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47922120 |
| 115 | Long-term potentiation_Homo sapiens_hsa04720 | 0.47215278 |
| 116 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.46632383 |
| 117 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.46527980 |
| 118 | Shigellosis_Homo sapiens_hsa05131 | 0.46152416 |
| 119 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.46100770 |
| 120 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.44783339 |
| 121 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.43534354 |
| 122 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.43067131 |
| 123 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38546975 |
| 124 | Carbon metabolism_Homo sapiens_hsa01200 | 0.38363394 |
| 125 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36451166 |

