ZBTB12BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)6.41414820
2regulation of chemokine biosynthetic process (GO:0045073)5.89144079
3macrophage differentiation (GO:0030225)5.79559171
4cytokine biosynthetic process (GO:0042089)5.50157462
5interkinetic nuclear migration (GO:0022027)5.12968564
6positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.89588856
7monoubiquitinated protein deubiquitination (GO:0035520)4.86729395
8negative regulation of interleukin-8 production (GO:0032717)4.55537800
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.48464515
10cytokine metabolic process (GO:0042107)4.46924312
11positive regulation of histone deacetylation (GO:0031065)4.40560175
12negative regulation of erythrocyte differentiation (GO:0045647)4.40235505
13histone H3-K9 modification (GO:0061647)4.39410836
14histone H3-K9 methylation (GO:0051567)4.36788279
15negative regulation of phagocytosis (GO:0050765)4.26808006
16modulation of growth of symbiont involved in interaction with host (GO:0044144)4.16264610
17regulation of growth of symbiont in host (GO:0044126)4.16264610
18negative regulation of growth of symbiont in host (GO:0044130)4.16264610
19negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.16264610
20mannose metabolic process (GO:0006013)4.11692443
21neutrophil mediated immunity (GO:0002446)4.07093449
22regulation of MHC class II biosynthetic process (GO:0045346)4.04822355
23maintenance of protein location in nucleus (GO:0051457)4.02542273
24positive regulation of chemokine biosynthetic process (GO:0045080)3.91477927
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.85243285
26response to muramyl dipeptide (GO:0032495)3.81182706
27protein K48-linked deubiquitination (GO:0071108)3.77749635
28microglial cell activation (GO:0001774)3.73891890
29regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.73738474
30disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.72190969
31killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.72190969
32oocyte maturation (GO:0001556)3.70574122
33regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.67605560
34histone H4-K16 acetylation (GO:0043984)3.64181352
35histone H4-K8 acetylation (GO:0043982)3.63655900
36histone H4-K5 acetylation (GO:0043981)3.63655900
37phagocytosis (GO:0006909)3.62312299
38misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.60929563
39histone H3-K4 methylation (GO:0051568)3.56336935
40carnitine transmembrane transport (GO:1902603)3.54979904
41lipid translocation (GO:0034204)3.52995774
42phospholipid translocation (GO:0045332)3.52995774
43positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.45140061
44regulation of RNA export from nucleus (GO:0046831)3.39721788
45cytoplasmic mRNA processing body assembly (GO:0033962)3.31727996
46cellular response to ethanol (GO:0071361)3.30161893
47histone H3-K4 trimethylation (GO:0080182)3.29504477
48positive regulation of protein deacetylation (GO:0090312)3.27910047
49myeloid leukocyte mediated immunity (GO:0002444)3.23564946
50transcription from mitochondrial promoter (GO:0006390)3.22188355
51histone deubiquitination (GO:0016578)3.19187916
52amino-acid betaine transport (GO:0015838)3.15108338
53carnitine transport (GO:0015879)3.15108338
54chromatin silencing (GO:0006342)3.15036243
55base-excision repair, AP site formation (GO:0006285)3.14748210
56positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.13806954
57focal adhesion assembly (GO:0048041)3.13719985
58cell-substrate adherens junction assembly (GO:0007045)3.13719985
59cellular response to exogenous dsRNA (GO:0071360)3.13208316
60cellular response to virus (GO:0098586)3.11791435
61negative regulation of cAMP-mediated signaling (GO:0043951)3.05701555
62response to peptidoglycan (GO:0032494)3.05042548
63histone lysine methylation (GO:0034968)3.04455948
64regulation of fatty acid beta-oxidation (GO:0031998)3.04401339
65histone H3-K36 demethylation (GO:0070544)3.03522444
66mRNA modification (GO:0016556)3.02752802
67response to misfolded protein (GO:0051788)3.02636255
68regulation of interleukin-12 biosynthetic process (GO:0045075)2.94002702
69snRNA metabolic process (GO:0016073)2.93854751
70regulation of histone deacetylation (GO:0031063)2.93826637
71negative regulation of multicellular organism growth (GO:0040015)2.92489936
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92078217
73negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90435670
74regulation of interleukin-8 biosynthetic process (GO:0045414)2.88169414
75induction of positive chemotaxis (GO:0050930)2.88132054
76reactive oxygen species biosynthetic process (GO:1903409)2.85801164
77negative regulation of chemokine production (GO:0032682)2.83867945
78purine deoxyribonucleotide catabolic process (GO:0009155)2.82644303
79negative regulation of cell size (GO:0045792)2.80698631
80macrophage activation (GO:0042116)2.79021818
81regulation of nucleobase-containing compound transport (GO:0032239)2.76430963
82positive regulation of developmental pigmentation (GO:0048087)2.73421881
83endosome to melanosome transport (GO:0035646)2.69219329
84endosome to pigment granule transport (GO:0043485)2.69219329
85pericardium development (GO:0060039)2.66747133
86negative regulation of gene expression, epigenetic (GO:0045814)2.66741771
87snRNA processing (GO:0016180)2.66531659
88peptidyl-lysine methylation (GO:0018022)2.66521145
89adherens junction assembly (GO:0034333)2.64426131
90mRNA cleavage (GO:0006379)2.64413137
91positive regulation of DNA biosynthetic process (GO:2000573)2.58579261
92regulation of monocyte differentiation (GO:0045655)2.56551943
93regulation of mast cell degranulation (GO:0043304)2.56188907
94cell-substrate junction assembly (GO:0007044)2.55246478
95histone methylation (GO:0016571)2.52499904
96glucocorticoid receptor signaling pathway (GO:0042921)2.49406516
97negative regulation of bone resorption (GO:0045779)2.47260337
98protein K63-linked deubiquitination (GO:0070536)2.45806854
99peptidyl-lysine dimethylation (GO:0018027)2.41333960
100regulation of chromatin binding (GO:0035561)2.40683198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.06270227
2MYC_22102868_ChIP-Seq_BL_Human3.69614407
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56168745
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.53418208
5SCL_19346495_ChIP-Seq_HPC-7_Human3.27942718
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.85188110
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.76994325
8LXR_22292898_ChIP-Seq_THP-1_Human2.70994907
9VDR_24763502_ChIP-Seq_THP-1_Human2.66728212
10TCF7_22412390_ChIP-Seq_EML_Mouse2.52873278
11KDM2B_26808549_Chip-Seq_DND41_Human2.37847154
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.33350700
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30901089
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25724902
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24394148
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12618232
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10606826
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.06881086
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05663387
20MAF_26560356_Chip-Seq_TH1_Human2.04407347
21MAF_26560356_Chip-Seq_TH2_Human1.98661181
22P68_20966046_ChIP-Seq_HELA_Human1.86555490
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80981103
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.79043978
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79000444
26GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76441937
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75300892
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72886725
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.72477173
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.67774350
31UTX_26944678_Chip-Seq_JUKART_Human1.67665790
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65494190
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64816587
34RACK7_27058665_Chip-Seq_MCF-7_Human1.61550056
35KDM2B_26808549_Chip-Seq_K562_Human1.61086690
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60757803
37SMC4_20622854_ChIP-Seq_HELA_Human1.59232894
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58575509
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52489975
40BCOR_27268052_Chip-Seq_Bcells_Human1.51238860
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.51166966
42DROSHA_22980978_ChIP-Seq_HELA_Human1.50796032
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.49966876
44SPI1_23127762_ChIP-Seq_K562_Human1.49719270
45GATA1_19941826_ChIP-Seq_K562_Human1.48672962
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47560654
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46940012
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.43138027
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43022890
50TP53_22127205_ChIP-Seq_IMR90_Human1.38939779
51BCL6_27268052_Chip-Seq_Bcells_Human1.37862641
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36286276
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.34943979
54SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34752434
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.34227787
56NCOR1_26117541_ChIP-Seq_K562_Human1.33696600
57MYB_26560356_Chip-Seq_TH1_Human1.32200078
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29701496
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29378147
60TP63_22573176_ChIP-Seq_HFKS_Human1.29002074
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24871483
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21968883
63OCT4_19829295_ChIP-Seq_ESCs_Human1.21127975
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20631141
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20453552
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19649565
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18747925
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18497855
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16615895
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16005057
71CREB1_26743006_Chip-Seq_LNCaP_Human1.15291899
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14518029
73PHF8_20622854_ChIP-Seq_HELA_Human1.14503071
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14124712
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14034714
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.14015723
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12255377
78CTCF_21964334_Chip-Seq_Bcells_Human1.12181251
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11154906
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.11062050
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09771542
82MYB_26560356_Chip-Seq_TH2_Human1.09508318
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09188851
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08565861
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.08295810
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08016965
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07191749
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06131780
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04818015
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04173642
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02880146
92RUNX_20019798_ChIP-Seq_JUKART_Human1.02843344
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02612962
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02376715
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.00622814
96E2F1_20622854_ChIP-Seq_HELA_Human1.00495432
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99904810
98CTCF_27219007_Chip-Seq_Bcells_Human0.99812233
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98127826
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97169825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue2.91064394
2MP0001851_eye_inflammation2.73809027
3MP0005076_abnormal_cell_differentiation2.57122783
4MP0003172_abnormal_lysosome_physiology2.23107227
5MP0002160_abnormal_reproductive_system2.15579761
6MP0004185_abnormal_adipocyte_glucose2.14306111
7MP0003763_abnormal_thymus_physiology2.07922406
8MP0000015_abnormal_ear_pigmentation2.04085047
9MP0003303_peritoneal_inflammation10.9372277
10MP0003705_abnormal_hypodermis_morpholog1.98239348
11MP0002332_abnormal_exercise_endurance1.97801004
12MP0004130_abnormal_muscle_cell1.88642712
13MP0005058_abnormal_lysosome_morphology1.88409494
14MP0005451_abnormal_body_composition1.81407763
15MP0001663_abnormal_digestive_system1.81112741
16MP0001533_abnormal_skeleton_physiology1.77769005
17MP0001849_ear_inflammation1.72943940
18MP0002405_respiratory_system_inflammati1.69741207
19MP0003436_decreased_susceptibility_to1.69662257
20MP0005220_abnormal_exocrine_pancreas1.66661045
21MP0002419_abnormal_innate_immunity1.64714284
22MP0002060_abnormal_skin_morphology1.62422948
23MP0002396_abnormal_hematopoietic_system1.54353231
24MP0003656_abnormal_erythrocyte_physiolo1.47848600
25MP0004808_abnormal_hematopoietic_stem1.42561797
26MP0005174_abnormal_tail_pigmentation1.39615544
27MP0005381_digestive/alimentary_phenotyp1.39434155
28MP0005025_abnormal_response_to1.36468249
29MP0003828_pulmonary_edema1.33724722
30MP0010155_abnormal_intestine_physiology1.33063075
31MP0004381_abnormal_hair_follicle1.30837269
32MP0005666_abnormal_adipose_tissue1.28099469
33MP0005409_darkened_coat_color1.27241092
34MP0001800_abnormal_humoral_immune1.26168080
35MP0003300_gastrointestinal_ulcer1.25881829
36MP0009333_abnormal_splenocyte_physiolog1.25641910
37MP0003091_abnormal_cell_migration1.21976983
38MP0005083_abnormal_biliary_tract1.18287405
39MP0008961_abnormal_basal_metabolism1.17854140
40MP0002420_abnormal_adaptive_immunity1.17278490
41MP0005397_hematopoietic_system_phenotyp1.15370438
42MP0001545_abnormal_hematopoietic_system1.15370438
43MP0001819_abnormal_immune_cell1.14510134
44MP0005390_skeleton_phenotype1.12561848
45MP0003045_fibrosis1.12424875
46MP0004233_abnormal_muscle_weight1.10375622
47MP0002166_altered_tumor_susceptibility1.09810772
48MP0003123_paternal_imprinting1.09096764
49MP0002970_abnormal_white_adipose1.08874131
50MP0001835_abnormal_antigen_presentation1.08277660
51MP0002398_abnormal_bone_marrow1.08059114
52MP0005360_urolithiasis1.06229623
53MP0002452_abnormal_antigen_presenting1.05504548
54MP0001790_abnormal_immune_system1.05140348
55MP0005387_immune_system_phenotype1.05140348
56MP0005266_abnormal_metabolism1.03872387
57MP0005000_abnormal_immune_tolerance1.03701902
58MP0002168_other_aberrant_phenotype1.01551915
59MP0004858_abnormal_nervous_system0.99639855
60MP0000685_abnormal_immune_system0.99402986
61MP0004510_myositis0.99242949
62MP0000716_abnormal_immune_system0.98660904
63MP0000733_abnormal_muscle_development0.94035006
64MP0002723_abnormal_immune_serum0.93006182
65MP0002089_abnormal_postnatal_growth/wei0.92977684
66MP0002722_abnormal_immune_system0.92413018
67MP0005389_reproductive_system_phenotype0.91847039
68MP0004147_increased_porphyrin_level0.91680920
69MP0009115_abnormal_fat_cell0.89312204
70MP0005375_adipose_tissue_phenotype0.89282212
71MP0005670_abnormal_white_adipose0.88069498
72MP0000703_abnormal_thymus_morphology0.86937173
73MP0002998_abnormal_bone_remodeling0.86614598
74MP0002429_abnormal_blood_cell0.83690339
75MP0001845_abnormal_inflammatory_respons0.83221165
76MP0003453_abnormal_keratinocyte_physiol0.80870849
77MP0000678_abnormal_parathyroid_gland0.79546334
78MP0010368_abnormal_lymphatic_system0.78710739
79MP0000759_abnormal_skeletal_muscle0.78228497
80MP0009278_abnormal_bone_marrow0.77720243
81MP0005334_abnormal_fat_pad0.77676216
82MP0004043_abnormal_pH_regulation0.77206361
83MP0005023_abnormal_wound_healing0.76281919
84MP0001270_distended_abdomen0.74098380
85MP0003795_abnormal_bone_structure0.73916543
86MP0005310_abnormal_salivary_gland0.71281438
87MP0002693_abnormal_pancreas_physiology0.71266161
88MP0004087_abnormal_muscle_fiber0.70922672
89MP0002933_joint_inflammation0.70624715
90MP0000249_abnormal_blood_vessel0.69636733
91MP0010352_gastrointestinal_tract_polyps0.68636786
92MP0000747_muscle_weakness0.68454580
93MP0000343_altered_response_to0.67812418
94MP0000689_abnormal_spleen_morphology0.67621742
95MP0004947_skin_inflammation0.64418243
96MP0002249_abnormal_larynx_morphology0.61846433
97MP0002148_abnormal_hypersensitivity_rea0.61406725
98MP0000569_abnormal_digit_pigmentation0.61163533
99MP0008260_abnormal_autophagy0.60311330
100MP0001873_stomach_inflammation0.59077962

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)4.53880785
2Asymmetric septal hypertrophy (HP:0001670)4.49515037
3Abnormality of the fingertips (HP:0001211)4.47817733
4Cutaneous melanoma (HP:0012056)3.99128482
5Dysmetric saccades (HP:0000641)3.96890475
6Abnormality of mucopolysaccharide metabolism (HP:0011020)3.70906161
7Abnormality of polysaccharide metabolism (HP:0011012)3.70906161
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.70906161
9Loss of speech (HP:0002371)3.64480549
10Urinary glycosaminoglycan excretion (HP:0003541)3.60067945
11Mucopolysacchariduria (HP:0008155)3.60067945
12Thrombocytosis (HP:0001894)3.50191635
13Neonatal hypoglycemia (HP:0001998)3.40984246
14Asymmetry of the thorax (HP:0001555)3.37967645
15Dysostosis multiplex (HP:0000943)3.30105762
16Genetic anticipation (HP:0003743)3.16233427
17Broad face (HP:0000283)3.13553295
18Lip pit (HP:0100267)2.97598464
19Ureteral stenosis (HP:0000071)2.97400809
20Persistence of primary teeth (HP:0006335)2.92761542
21Urethral obstruction (HP:0000796)2.90467383
22Thoracic kyphosis (HP:0002942)2.89131348
23Spondylolisthesis (HP:0003302)2.83511593
24Long eyelashes (HP:0000527)2.82949342
25Soft skin (HP:0000977)2.80802137
26Poor head control (HP:0002421)2.75777617
27Self-mutilation (HP:0000742)2.66707204
28Distal lower limb amyotrophy (HP:0008944)2.65386945
29Ureteral obstruction (HP:0006000)2.63510391
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62561589
31Acute lymphatic leukemia (HP:0006721)2.60711456
32Supernumerary nipples (HP:0002558)2.60196252
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.55936635
34Natal tooth (HP:0000695)2.55144009
35Abnormality of the thoracic spine (HP:0100711)2.50608884
36Granulocytopenia (HP:0001913)2.47459719
37Lymphangioma (HP:0100764)2.44146512
38Ovoid vertebral bodies (HP:0003300)2.41801059
39Bladder diverticulum (HP:0000015)2.40026570
40Visual hallucinations (HP:0002367)2.34762054
41Increased cerebral lipofuscin (HP:0011813)2.31150961
42Sparse lateral eyebrow (HP:0005338)2.27292776
43Cerebral aneurysm (HP:0004944)2.26986170
44Abnormality of the columella (HP:0009929)2.20597471
45Hyperlipoproteinemia (HP:0010980)2.20252883
46Obstructive sleep apnea (HP:0002870)2.16733916
47Periodontitis (HP:0000704)2.15099543
48Joint stiffness (HP:0001387)2.14187244
49Eosinophilia (HP:0001880)2.13813064
50Cervical subluxation (HP:0003308)2.12814228
51Prominent nose (HP:0000448)2.07008995
52Visceral angiomatosis (HP:0100761)2.05028931
53Long foot (HP:0001833)2.03650549
54Short chin (HP:0000331)2.03384007
55Disproportionate tall stature (HP:0001519)2.02918519
56Genu recurvatum (HP:0002816)2.02678772
57Colitis (HP:0002583)2.01320688
58Ulnar deviation of the wrist (HP:0003049)2.01306872
59Rib fusion (HP:0000902)2.01159366
60Impaired smooth pursuit (HP:0007772)2.00456630
61Hypertriglyceridemia (HP:0002155)1.99310054
62Narrow palate (HP:0000189)1.97927525
63Bronchomalacia (HP:0002780)1.96938634
64Anal stenosis (HP:0002025)1.96057047
65Bicuspid aortic valve (HP:0001647)1.95604591
66Autoimmune thrombocytopenia (HP:0001973)1.94590443
67Lower limb amyotrophy (HP:0007210)1.91214865
68Abnormality of carpal bone ossification (HP:0006257)1.89159386
69Hemorrhage of the eye (HP:0011885)1.88070447
70Epiphyseal dysplasia (HP:0002656)1.87577757
71Long palpebral fissure (HP:0000637)1.87142878
72Hematochezia (HP:0002573)1.81350796
73Broad distal phalanx of finger (HP:0009836)1.78665896
74Spontaneous hematomas (HP:0007420)1.75105585
75Tracheomalacia (HP:0002779)1.74557402
76Protruding tongue (HP:0010808)1.74557180
77Dislocated radial head (HP:0003083)1.72043703
78Increased connective tissue (HP:0009025)1.71701837
79Flat face (HP:0012368)1.71300894
80Hemangiomatosis (HP:0007461)1.71252042
81Abnormal ossification of hand bones (HP:0005921)1.70721437
82Ulnar bowing (HP:0003031)1.70045154
83Hypoalphalipoproteinemia (HP:0003233)1.69173601
84Macroorchidism (HP:0000053)1.68163226
85Albinism (HP:0001022)1.67569342
86Large eyes (HP:0001090)1.66386200
87Germ cell neoplasia (HP:0100728)1.64912615
88Hyperacusis (HP:0010780)1.64900784
89Tented upper lip vermilion (HP:0010804)1.64467681
90Abnormality of the phalanges of the hallux (HP:0010057)1.63492046
91Upper limb amyotrophy (HP:0009129)1.62570516
92Distal upper limb amyotrophy (HP:0007149)1.62570516
93Abnormality of eosinophils (HP:0001879)1.61111448
94Squamous cell carcinoma (HP:0002860)1.61063369
95Synophrys (HP:0000664)1.60866276
96Thin bony cortex (HP:0002753)1.60057864
97Overfolded helix (HP:0000396)1.59497976
98Abnormality of skull ossification (HP:0002703)1.59497156
99Plagiocephaly (HP:0001357)1.59284938
100Advanced eruption of teeth (HP:0006288)1.58626325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK27.93186360
2LATS15.33550657
3ERN13.88436605
4CDK123.85312814
5TRIB32.91703662
6MAP2K32.90849888
7NUAK12.15534167
8PIM22.12359083
9FRK1.94172643
10ICK1.82825490
11TLK11.67830573
12SIK11.57013691
13TNK21.53937057
14TGFBR21.49371304
15MAP3K131.41071357
16PRPF4B1.40430190
17CAMK1D1.29481094
18CDC42BPA1.29196593
19MTOR1.25443313
20MAPK41.24606025
21MAP4K11.21205391
22MAP2K61.16134657
23TYRO31.13627977
24BMX1.11971655
25MAP3K61.00481924
26SIK20.98165279
27BLK0.97467168
28MARK20.95165069
29ACVR1B0.94072065
30MAP3K70.93785736
31TTN0.92652114
32CAMK1G0.91908115
33STK240.91872980
34TAOK10.89511932
35FGFR20.88029209
36TRPM70.87226029
37PRKD20.84852841
38MAP3K100.83832861
39TBK10.83543539
40MAP3K140.83011390
41EEF2K0.82235168
42GRK60.80406487
43WNK10.80033373
44STK30.79563998
45MAP3K110.75038687
46IKBKB0.73759402
47ZAP700.73264310
48GRK70.71570302
49IRAK40.69424695
50IRAK20.68958449
51SMG10.68868110
52PKN20.67021500
53IRAK30.66963567
54CHUK0.65955976
55MAPK70.65170068
56PDPK10.63328420
57MAPK110.59474785
58PTK60.57159885
59MAPK80.56953620
60PDK10.55443772
61MAP3K30.52688778
62FGFR30.52282229
63MELK0.51190910
64RPS6KC10.50120913
65RPS6KL10.50120913
66HCK0.50104725
67RPS6KA60.50078101
68FGFR40.48827818
69MAP3K10.48498950
70FES0.48290606
71INSRR0.48001798
72BTK0.47027403
73PRKAA20.46362445
74MAP2K40.45653889
75IKBKE0.44721537
76HIPK20.44534894
77JAK10.44227095
78ADRBK20.43029921
79PDGFRB0.42415537
80TAOK20.41784858
81AKT30.41381280
82PIM10.41373417
83PRKAA10.40658347
84BRD40.38139764
85KIT0.36753222
86MAPK100.36452647
87RAF10.36324627
88TYK20.36230670
89MOS0.35321130
90ADRBK10.34760713
91SYK0.33180354
92STK110.32903425
93WNK40.31903334
94BMPR1B0.30699582
95MAPKAPK30.30064704
96MAP2K20.29983993
97RIPK10.28672246
98PAK20.28494746
99CSF1R0.27655566
100JAK30.26731340

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.98020273
2Lysine degradation_Homo sapiens_hsa003102.75942715
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.70477381
4Other glycan degradation_Homo sapiens_hsa005112.49327642
5VEGF signaling pathway_Homo sapiens_hsa043702.20291035
6Notch signaling pathway_Homo sapiens_hsa043301.86719845
7Acute myeloid leukemia_Homo sapiens_hsa052211.70032856
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63187252
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62775626
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60421126
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48718107
12mTOR signaling pathway_Homo sapiens_hsa041501.47644027
13Osteoclast differentiation_Homo sapiens_hsa043801.46426066
14Chronic myeloid leukemia_Homo sapiens_hsa052201.45861211
15B cell receptor signaling pathway_Homo sapiens_hsa046621.44060260
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.43637858
17Type II diabetes mellitus_Homo sapiens_hsa049301.38871408
18Systemic lupus erythematosus_Homo sapiens_hsa053221.32728872
19Platelet activation_Homo sapiens_hsa046111.29629442
20Non-small cell lung cancer_Homo sapiens_hsa052231.27563802
21Ovarian steroidogenesis_Homo sapiens_hsa049131.25937727
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25780790
23Bladder cancer_Homo sapiens_hsa052191.23029651
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.22687246
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22537241
26Primary immunodeficiency_Homo sapiens_hsa053401.20873127
27Inositol phosphate metabolism_Homo sapiens_hsa005621.20438887
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18248808
29Pancreatic cancer_Homo sapiens_hsa052121.18058357
30T cell receptor signaling pathway_Homo sapiens_hsa046601.16677077
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15924471
32TNF signaling pathway_Homo sapiens_hsa046681.13539068
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12554108
34Insulin resistance_Homo sapiens_hsa049311.10446286
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09857461
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09628242
37Toxoplasmosis_Homo sapiens_hsa051451.08149789
38FoxO signaling pathway_Homo sapiens_hsa040681.04755781
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96394426
40GnRH signaling pathway_Homo sapiens_hsa049120.94870265
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93111089
42Leishmaniasis_Homo sapiens_hsa051400.92757631
43ABC transporters_Homo sapiens_hsa020100.90901255
44MicroRNAs in cancer_Homo sapiens_hsa052060.90654703
45Hepatitis B_Homo sapiens_hsa051610.90034437
46MAPK signaling pathway_Homo sapiens_hsa040100.88857515
47Influenza A_Homo sapiens_hsa051640.88493863
48Lysosome_Homo sapiens_hsa041420.88398121
49Small cell lung cancer_Homo sapiens_hsa052220.87728902
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.87558312
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.87231086
52Calcium signaling pathway_Homo sapiens_hsa040200.86364209
53Melanoma_Homo sapiens_hsa052180.85586919
54Malaria_Homo sapiens_hsa051440.85047678
55Hepatitis C_Homo sapiens_hsa051600.84865672
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83691681
57Prolactin signaling pathway_Homo sapiens_hsa049170.83237520
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82135583
59Endometrial cancer_Homo sapiens_hsa052130.81036560
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81017988
61Tuberculosis_Homo sapiens_hsa051520.77155823
62Prostate cancer_Homo sapiens_hsa052150.76560945
63Herpes simplex infection_Homo sapiens_hsa051680.75694176
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.74181045
65Choline metabolism in cancer_Homo sapiens_hsa052310.73866143
66Insulin signaling pathway_Homo sapiens_hsa049100.72452654
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71851178
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71548332
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.71229167
70Linoleic acid metabolism_Homo sapiens_hsa005910.68329586
71ErbB signaling pathway_Homo sapiens_hsa040120.66032032
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66012087
73Rap1 signaling pathway_Homo sapiens_hsa040150.63435266
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62738524
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.61842019
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.61668164
77Measles_Homo sapiens_hsa051620.61037940
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.60387816
79Colorectal cancer_Homo sapiens_hsa052100.59965468
80Apoptosis_Homo sapiens_hsa042100.59828589
81Viral carcinogenesis_Homo sapiens_hsa052030.59076409
82Vitamin digestion and absorption_Homo sapiens_hsa049770.59045336
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57823360
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57173763
85African trypanosomiasis_Homo sapiens_hsa051430.57025943
86Glioma_Homo sapiens_hsa052140.56346309
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53967178
88Amoebiasis_Homo sapiens_hsa051460.53895853
89HTLV-I infection_Homo sapiens_hsa051660.52387625
90Focal adhesion_Homo sapiens_hsa045100.52059234
91Long-term depression_Homo sapiens_hsa047300.51059381
92Hematopoietic cell lineage_Homo sapiens_hsa046400.50785219
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.48882717
94Glycerolipid metabolism_Homo sapiens_hsa005610.48835705
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48376193
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46851583
97Epstein-Barr virus infection_Homo sapiens_hsa051690.46070820
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.45001653
99Renin secretion_Homo sapiens_hsa049240.44396041
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43523233

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