ZBTB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)4.27612676
2intra-S DNA damage checkpoint (GO:0031573)4.26907399
3positive regulation of granulocyte differentiation (GO:0030854)4.22703446
4negative thymic T cell selection (GO:0045060)4.18800486
5auditory receptor cell differentiation (GO:0042491)4.01849113
6positive T cell selection (GO:0043368)4.01457428
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98945639
8definitive hemopoiesis (GO:0060216)3.98022993
9lymphoid progenitor cell differentiation (GO:0002320)3.94296341
10B cell receptor signaling pathway (GO:0050853)3.82561296
11DNA replication initiation (GO:0006270)3.79929399
12histone H4-K12 acetylation (GO:0043983)3.79013428
13DNA unwinding involved in DNA replication (GO:0006268)3.73480258
14response to interleukin-15 (GO:0070672)3.73357955
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68877271
16negative regulation of erythrocyte differentiation (GO:0045647)3.65947017
17activated T cell proliferation (GO:0050798)3.63874185
18megakaryocyte development (GO:0035855)3.63136168
19positive regulation of histone H3-K4 methylation (GO:0051571)3.60889073
20regulation of gamma-delta T cell activation (GO:0046643)3.59392395
21mitotic sister chromatid cohesion (GO:0007064)3.58479087
22cellular response to interleukin-15 (GO:0071350)3.55572365
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53519991
24T cell selection (GO:0045058)3.53504659
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49099767
26positive regulation of B cell differentiation (GO:0045579)3.48345973
27telomere maintenance via semi-conservative replication (GO:0032201)3.46951551
28neutrophil activation involved in immune response (GO:0002283)3.45612165
29protein localization to kinetochore (GO:0034501)3.45164019
30histone H2A acetylation (GO:0043968)3.41166090
31positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36039963
32T cell migration (GO:0072678)3.31915606
33positive thymic T cell selection (GO:0045059)3.28038071
34positive regulation of gamma-delta T cell activation (GO:0046645)3.27968959
35telomere maintenance via recombination (GO:0000722)3.22331900
36mitotic recombination (GO:0006312)3.21677418
37DNA strand elongation involved in DNA replication (GO:0006271)3.20376727
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.19098664
39interferon-gamma production (GO:0032609)3.15483799
40DNA double-strand break processing (GO:0000729)3.11160770
41DNA strand renaturation (GO:0000733)3.10255964
42leukocyte aggregation (GO:0070486)3.09723610
43regulation of chromatin binding (GO:0035561)3.08256581
44regulation of DNA endoreduplication (GO:0032875)3.08051595
45regulation of fibroblast apoptotic process (GO:2000269)3.07853906
46negative regulation of phagocytosis (GO:0050765)3.06511279
47interkinetic nuclear migration (GO:0022027)3.04675141
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.04386810
49inner ear receptor cell development (GO:0060119)3.03911033
50antigen processing and presentation of endogenous antigen (GO:0019883)3.03755974
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.03570349
52regulation of Golgi to plasma membrane protein transport (GO:0042996)3.03235707
53DNA synthesis involved in DNA repair (GO:0000731)3.01563283
54ribosomal small subunit assembly (GO:0000028)3.00722847
55V(D)J recombination (GO:0033151)3.00613705
56kinetochore organization (GO:0051383)3.00384533
57DNA strand elongation (GO:0022616)3.00146262
58regulation of alpha-beta T cell proliferation (GO:0046640)2.99451414
59alternative mRNA splicing, via spliceosome (GO:0000380)2.98727213
60embryonic hemopoiesis (GO:0035162)2.97449730
61T cell homeostasis (GO:0043029)2.97334542
62dosage compensation (GO:0007549)2.97133278
63regulation of histone H3-K4 methylation (GO:0051569)2.95466319
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94098252
65negative regulation of translation, ncRNA-mediated (GO:0040033)2.94098252
66regulation of translation, ncRNA-mediated (GO:0045974)2.94098252
67mucosal-associated lymphoid tissue development (GO:0048537)2.93874262
68Peyers patch development (GO:0048541)2.93874262
69positive regulation of RNA splicing (GO:0033120)2.90705741
70thymic T cell selection (GO:0045061)2.90467958
71execution phase of apoptosis (GO:0097194)2.88027637
72DNA topological change (GO:0006265)2.87605615
73histone mRNA catabolic process (GO:0071044)2.87376439
74N-terminal protein amino acid acetylation (GO:0006474)2.85361818
75mitotic G2 DNA damage checkpoint (GO:0007095)2.85312233
76tolerance induction (GO:0002507)2.83736153
77inositol phosphate catabolic process (GO:0071545)2.83707238
78negative regulation of RNA splicing (GO:0033119)2.81973322
79regulation of granulocyte differentiation (GO:0030852)2.79185079
80protein K11-linked deubiquitination (GO:0035871)2.78851703
81DNA duplex unwinding (GO:0032508)2.77766346
82antigen receptor-mediated signaling pathway (GO:0050851)2.77710579
83antigen processing and presentation via MHC class Ib (GO:0002475)2.74806051
84neutrophil activation (GO:0042119)2.74559484
85DNA geometric change (GO:0032392)2.73066621
86histone H3-K36 demethylation (GO:0070544)2.72721216
87glial cell proliferation (GO:0014009)2.71348348
88negative regulation of T cell apoptotic process (GO:0070233)2.70722275
89mRNA splice site selection (GO:0006376)2.69353652
90post-embryonic morphogenesis (GO:0009886)2.68503000
91regulation of B cell receptor signaling pathway (GO:0050855)2.68334777
92nuclear pore complex assembly (GO:0051292)2.67014762
93negative regulation of histone methylation (GO:0031061)2.66870978
94negative regulation of T cell mediated immunity (GO:0002710)2.65844842
95DNA replication checkpoint (GO:0000076)2.64998861
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64930499
97regulation of helicase activity (GO:0051095)2.64741607
98regulation of mRNA splicing, via spliceosome (GO:0048024)2.63299006
99DNA replication-independent nucleosome organization (GO:0034724)2.63069120
100DNA replication-independent nucleosome assembly (GO:0006336)2.63069120
101histone H3-K4 trimethylation (GO:0080182)2.62942726
102T cell receptor signaling pathway (GO:0050852)2.62859199
103positive regulation of interleukin-2 production (GO:0032743)2.62734361
104leukocyte degranulation (GO:0043299)2.62703847
105regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62435545
106CENP-A containing nucleosome assembly (GO:0034080)2.61630318
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60946579
108leukocyte migration involved in inflammatory response (GO:0002523)2.60679328
109negative regulation of T-helper cell differentiation (GO:0045623)2.60668544
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60668544
111erythrocyte maturation (GO:0043249)2.59658385
112IMP biosynthetic process (GO:0006188)2.59152736
113mitotic G2/M transition checkpoint (GO:0044818)2.57635765
114COPI coating of Golgi vesicle (GO:0048205)2.57391309
115Golgi transport vesicle coating (GO:0048200)2.57391309
116negative regulation of fibroblast apoptotic process (GO:2000270)2.56741134
117positive regulation of response to oxidative stress (GO:1902884)2.56677473
118positive regulation of cellular response to oxidative stress (GO:1900409)2.56677473
119neural tube formation (GO:0001841)2.56380664
120T cell differentiation (GO:0030217)2.56053839
121positive regulation of histone methylation (GO:0031062)2.55832054
122lymphocyte homeostasis (GO:0002260)2.55813311
123monoubiquitinated protein deubiquitination (GO:0035520)2.55545693
124positive regulation by symbiont of host defense response (GO:0052509)2.54801508
125modulation by symbiont of host defense response (GO:0052031)2.54801508
126modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54801508
127modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54801508
128positive regulation by organism of defense response of other organism involved in symbiotic interact2.54801508
129modulation by symbiont of host immune response (GO:0052553)2.54801508
130B cell homeostasis (GO:0001782)2.54718706
131histone H3-K4 methylation (GO:0051568)2.54042714
132mast cell activation involved in immune response (GO:0002279)2.53692678
133mast cell degranulation (GO:0043303)2.53692678
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52532871
135histone deubiquitination (GO:0016578)2.52233821
136regulation of histone H3-K9 methylation (GO:0051570)2.52211521
137peptidyl-lysine dimethylation (GO:0018027)2.49742103
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49340152
139negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49340152
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49340152
141negative regulation of mitotic sister chromatid separation (GO:2000816)2.49340152
142negative regulation of sister chromatid segregation (GO:0033046)2.49340152
143chromatin remodeling at centromere (GO:0031055)2.49325808
144histone H3-K9 modification (GO:0061647)2.48912797
145mast cell activation (GO:0045576)2.48799752
146negative regulation of gene expression, epigenetic (GO:0045814)2.48604631
147protein localization to chromosome, centromeric region (GO:0071459)2.47834810
148hair cell differentiation (GO:0035315)2.46921364
149regulation of gamma-delta T cell differentiation (GO:0045586)2.45074950
150regulation of DNA damage checkpoint (GO:2000001)2.44600054
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44345192
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44345192
153regulation of B cell differentiation (GO:0045577)2.44336009
154kinetochore assembly (GO:0051382)2.44009675
155histone H4-K8 acetylation (GO:0043982)2.42844845
156histone H4-K5 acetylation (GO:0043981)2.42844845
157SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42606679
158negative regulation of cAMP-mediated signaling (GO:0043951)2.41769346
159glucocorticoid receptor signaling pathway (GO:0042921)2.41305685
160nucleotide-excision repair, DNA gap filling (GO:0006297)2.40656517
161prostate gland growth (GO:0060736)2.40561380
162spindle checkpoint (GO:0031577)2.39920426
163RNA export from nucleus (GO:0006405)2.39275289
164peptidyl-lysine trimethylation (GO:0018023)2.38892718
165ATP-dependent chromatin remodeling (GO:0043044)2.38136821
166regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.38014986
167positive regulation of transcription regulatory region DNA binding (GO:2000679)2.36142307
168mitotic spindle checkpoint (GO:0071174)2.36103905
169cotranslational protein targeting to membrane (GO:0006613)2.35420910
170replication fork processing (GO:0031297)2.34378285
171histone H3 deacetylation (GO:0070932)2.34341848
172mRNA export from nucleus (GO:0006406)2.34253244
173ER overload response (GO:0006983)2.34145252
174protein targeting to ER (GO:0045047)2.34142339
175negative regulation of cell killing (GO:0031342)2.33813627
176negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33813627
177DNA damage response, detection of DNA damage (GO:0042769)2.33566393
178type B pancreatic cell development (GO:0003323)2.32192760
179spindle assembly checkpoint (GO:0071173)2.32064990
180histone H4-K16 acetylation (GO:0043984)2.31474575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human3.62163813
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.48897986
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45712405
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30373476
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.97238328
6IGF1R_20145208_ChIP-Seq_DFB_Human2.89217168
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82562616
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.65169136
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.62006679
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.48152968
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.46623799
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45009337
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37917170
14MYC_22102868_ChIP-Seq_BL_Human2.34624814
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32790216
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25043762
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22768991
18CIITA_25753668_ChIP-Seq_RAJI_Human2.20215609
19EZH2_22144423_ChIP-Seq_EOC_Human2.19683450
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18700113
21HOXB4_20404135_ChIP-ChIP_EML_Mouse2.17405923
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17229779
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10295661
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.08556452
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08194188
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07105304
27E2F7_22180533_ChIP-Seq_HELA_Human10.4447222
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.93992422
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93640035
30FOXP3_21729870_ChIP-Seq_TREG_Human1.93044919
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89476265
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.87576219
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83860093
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.82907309
35VDR_23849224_ChIP-Seq_CD4+_Human1.81539421
36ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81303928
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74567058
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72136829
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69115200
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68340635
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68306076
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66150396
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.66066666
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63714315
45GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.62981036
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61888569
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60823550
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.60155553
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59000401
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54561760
51ELK1_19687146_ChIP-ChIP_HELA_Human1.53925384
52TCF7_22412390_ChIP-Seq_EML_Mouse1.53314546
53TAF15_26573619_Chip-Seq_HEK293_Human1.51041085
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46970630
55GATA1_22025678_ChIP-Seq_K562_Human1.46216607
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43130220
57VDR_21846776_ChIP-Seq_THP-1_Human1.41835219
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41212910
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41008533
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.38334856
61EWS_26573619_Chip-Seq_HEK293_Human1.36952519
62GATA3_27048872_Chip-Seq_THYMUS_Human1.35398511
63MYB_26560356_Chip-Seq_TH1_Human1.33508441
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33058524
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32463314
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31811135
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31579364
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31294641
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31279743
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26520827
71MYB_26560356_Chip-Seq_TH2_Human1.26406536
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25361402
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24294642
74SPI1_23547873_ChIP-Seq_NB4_Human1.23939462
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23304325
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22811465
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21961826
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21846033
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21679945
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21231875
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21049004
82GBX2_23144817_ChIP-Seq_PC3_Human1.20277244
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18959170
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18795634
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18312149
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16436199
87RUNX_20019798_ChIP-Seq_JUKART_Human1.15289696
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15060986
89TFEB_21752829_ChIP-Seq_HELA_Human1.14786088
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13947677
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12203791
92TTF2_22483619_ChIP-Seq_HELA_Human1.11737409
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10533082
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10168296
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09824984
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.09712560
97XRN2_22483619_ChIP-Seq_HELA_Human1.09636836
98SALL4_22934838_ChIP-ChIP_CD34+_Human1.09553328
99FUS_26573619_Chip-Seq_HEK293_Human1.09220221
100AR_21909140_ChIP-Seq_LNCAP_Human1.06594587
101GATA3_26560356_Chip-Seq_TH2_Human1.06068108
102UTX_26944678_Chip-Seq_JUKART_Human1.04924571
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04618230
104PU_27001747_Chip-Seq_BMDM_Mouse1.03298556
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.02663200
106P300_19829295_ChIP-Seq_ESCs_Human1.01881537
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.01515987
108MYC_18940864_ChIP-ChIP_HL60_Human1.01203448
109BCAT_22108803_ChIP-Seq_LS180_Human1.00963272
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00689813
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00208718
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99875249
113ER_23166858_ChIP-Seq_MCF-7_Human0.99562619
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98948113
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98455010
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.98136404
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97272389
118STAT3_23295773_ChIP-Seq_U87_Human0.96325869
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96082222
120IRF1_19129219_ChIP-ChIP_H3396_Human0.95445873
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95277157
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95077171
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94901075
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94895811
125GABP_19822575_ChIP-Seq_HepG2_Human0.94765681
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94604926
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93961635
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92794713
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.92627528
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91559141
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.91386984
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91053710
133ZNF274_21170338_ChIP-Seq_K562_Hela0.90676038
134SPI1_23127762_ChIP-Seq_K562_Human0.90234023
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89866884
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89481894
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88713442
138MAF_26560356_Chip-Seq_TH1_Human0.88515930
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88169889
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87104896
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86511432
142GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86260213
143VDR_24763502_ChIP-Seq_THP-1_Human0.85880337
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85002073
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84733340
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84711352
147SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84483534
148SMAD4_21799915_ChIP-Seq_A2780_Human0.84212552
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83499640
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83361640
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82850835
152E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81900621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.21248189
2MP0002877_abnormal_melanocyte_morpholog3.52341485
3MP0003303_peritoneal_inflammation3.27890928
4MP0005174_abnormal_tail_pigmentation3.26882650
5MP0008057_abnormal_DNA_replication3.03922255
6MP0004808_abnormal_hematopoietic_stem2.82883523
7MP0003693_abnormal_embryo_hatching2.74918084
8MP0000015_abnormal_ear_pigmentation2.67675515
9MP0005379_endocrine/exocrine_gland_phen2.65654500
10MP0006292_abnormal_olfactory_placode2.39620523
11MP0003724_increased_susceptibility_to2.38929581
12MP0002396_abnormal_hematopoietic_system2.36132378
13MP0001188_hyperpigmentation2.19164821
14MP0005075_abnormal_melanosome_morpholog2.15792223
15MP0002095_abnormal_skin_pigmentation2.11580561
16MP0004147_increased_porphyrin_level2.11212174
17MP0010094_abnormal_chromosome_stability2.06495203
18MP0003890_abnormal_embryonic-extraembry1.96548241
19MP0002009_preneoplasia1.89335491
20MP0001835_abnormal_antigen_presentation1.87534298
21MP0002909_abnormal_adrenal_gland1.86453804
22MP0001944_abnormal_pancreas_morphology1.82397415
23MP0008058_abnormal_DNA_repair1.81096129
24MP0003866_abnormal_defecation1.79441071
25MP0002693_abnormal_pancreas_physiology1.77810460
26MP0003123_paternal_imprinting1.74748578
27MP0003763_abnormal_thymus_physiology1.73072236
28MP0004134_abnormal_chest_morphology1.69878113
29MP0003787_abnormal_imprinting1.69063378
30MP0002723_abnormal_immune_serum1.68812195
31MP0001986_abnormal_taste_sensitivity1.68744196
32MP0009379_abnormal_foot_pigmentation1.68580343
33MP0003111_abnormal_nucleus_morphology1.68528343
34MP0002452_abnormal_antigen_presenting1.66841152
35MP0000678_abnormal_parathyroid_gland1.64518500
36MP0003300_gastrointestinal_ulcer1.63682692
37MP0003121_genomic_imprinting1.63444000
38MP0004885_abnormal_endolymph1.61557315
39MP0005248_abnormal_Harderian_gland1.60846558
40MP0005000_abnormal_immune_tolerance1.57004956
41MP0004957_abnormal_blastocyst_morpholog1.56767522
42MP0006054_spinal_hemorrhage1.56607692
43MP0003122_maternal_imprinting1.54537256
44MP0008877_abnormal_DNA_methylation1.52409956
45MP0002405_respiratory_system_inflammati1.51580350
46MP0003077_abnormal_cell_cycle1.51489531
47MP0002166_altered_tumor_susceptibility1.50054190
48MP0005397_hematopoietic_system_phenotyp1.49810322
49MP0001545_abnormal_hematopoietic_system1.49810322
50MP0008007_abnormal_cellular_replicative1.49732159
51MP0000490_abnormal_crypts_of1.45637674
52MP0002138_abnormal_hepatobiliary_system1.44048647
53MP0001790_abnormal_immune_system1.43305374
54MP0005387_immune_system_phenotype1.43305374
55MP0009697_abnormal_copulation1.41043232
56MP0000703_abnormal_thymus_morphology1.40563603
57MP0002398_abnormal_bone_marrow1.37835763
58MP0003943_abnormal_hepatobiliary_system1.36228003
59MP0005310_abnormal_salivary_gland1.33098272
60MP0010307_abnormal_tumor_latency1.30535964
61MP0000681_abnormal_thyroid_gland1.29752141
62MP0002102_abnormal_ear_morphology1.28665702
63MP0002938_white_spotting1.28257045
64MP0004185_abnormal_adipocyte_glucose1.25510013
65MP0005671_abnormal_response_to1.24518988
66MP0002751_abnormal_autonomic_nervous1.23641111
67MP0004264_abnormal_extraembryonic_tissu1.18563040
68MP0005025_abnormal_response_to1.14309812
69MP0003221_abnormal_cardiomyocyte_apopto1.14009847
70MP0002419_abnormal_innate_immunity1.13829332
71MP0000685_abnormal_immune_system1.12275018
72MP0000631_abnormal_neuroendocrine_gland1.11508553
73MP0002234_abnormal_pharynx_morphology1.11016789
74MP0005187_abnormal_penis_morphology1.08135062
75MP0000613_abnormal_salivary_gland1.06767936
76MP0002876_abnormal_thyroid_physiology1.06412047
77MP0000689_abnormal_spleen_morphology1.04185859
78MP0002075_abnormal_coat/hair_pigmentati1.02433860
79MP0002722_abnormal_immune_system1.02276778
80MP0002177_abnormal_outer_ear1.02120227
81MP0001879_abnormal_lymphatic_vessel1.01996951
82MP0000371_diluted_coat_color0.98045884
83MP0001186_pigmentation_phenotype0.97902588
84MP0005409_darkened_coat_color0.96015881
85MP0003567_abnormal_fetal_cardiomyocyte0.95426316
86MP0009333_abnormal_splenocyte_physiolog0.94896045
87MP0000778_abnormal_nervous_system0.93965675
88MP0002006_tumorigenesis0.93697133
89MP0003656_abnormal_erythrocyte_physiolo0.93598097
90MP0003868_abnormal_feces_composition0.92594415
91MP0005083_abnormal_biliary_tract0.91515089
92MP0000313_abnormal_cell_death0.90514371
93MP0003878_abnormal_ear_physiology0.89940109
94MP0005377_hearing/vestibular/ear_phenot0.89940109
95MP0002638_abnormal_pupillary_reflex0.89715288
96MP0000013_abnormal_adipose_tissue0.89068541
97MP0000465_gastrointestinal_hemorrhage0.88505481
98MP0009785_altered_susceptibility_to0.88346452
99MP0004145_abnormal_muscle_electrophysio0.88066113
100MP0000049_abnormal_middle_ear0.87457455
101MP0010386_abnormal_urinary_bladder0.87131732
102MP0001293_anophthalmia0.86055750
103MP0002429_abnormal_blood_cell0.85737333
104MP0000716_abnormal_immune_system0.84762479
105MP0003436_decreased_susceptibility_to0.84602259
106MP0002277_abnormal_respiratory_mucosa0.84562065
107MP0010352_gastrointestinal_tract_polyps0.84438640
108MP0002078_abnormal_glucose_homeostasis0.84391889
109MP0005646_abnormal_pituitary_gland0.84267183
110MP0005645_abnormal_hypothalamus_physiol0.83557302
111MP0004130_abnormal_muscle_cell0.83453653
112MP0006072_abnormal_retinal_apoptosis0.82464209
113MP0001697_abnormal_embryo_size0.82292764
114MP0002928_abnormal_bile_duct0.81693247
115MP0000350_abnormal_cell_proliferation0.81258144
116MP0004381_abnormal_hair_follicle0.80036771
117MP0001177_atelectasis0.79990922
118MP0009672_abnormal_birth_weight0.78845540
119MP0001851_eye_inflammation0.78557376
120MP0002970_abnormal_white_adipose0.77785645
121MP0009703_decreased_birth_body0.76858625
122MP0000427_abnormal_hair_cycle0.75834776
123MP0005220_abnormal_exocrine_pancreas0.75050897
124MP0002019_abnormal_tumor_incidence0.74211700
125MP0010155_abnormal_intestine_physiology0.74025909
126MP0008932_abnormal_embryonic_tissue0.73537363
127MP0004197_abnormal_fetal_growth/weight/0.72371993
128MP0003183_abnormal_peptide_metabolism0.70625328
129MP0003718_maternal_effect0.70505002
130MP0002420_abnormal_adaptive_immunity0.70300931
131MP0005380_embryogenesis_phenotype0.69909681
132MP0001672_abnormal_embryogenesis/_devel0.69909681
133MP0005464_abnormal_platelet_physiology0.69618282
134MP0002088_abnormal_embryonic_growth/wei0.69561564
135MP0001800_abnormal_humoral_immune0.69171045
136MP0003984_embryonic_growth_retardation0.68801627
137MP0001845_abnormal_inflammatory_respons0.67954657
138MP0005084_abnormal_gallbladder_morpholo0.67461439
139MP0001819_abnormal_immune_cell0.66639422
140MP0001929_abnormal_gametogenesis0.65927646
141MP0002080_prenatal_lethality0.65684147
142MP0008961_abnormal_basal_metabolism0.65440030
143MP0002084_abnormal_developmental_patter0.65047653
144MP0000647_abnormal_sebaceous_gland0.64545459
145MP0003828_pulmonary_edema0.60544576
146MP0001730_embryonic_growth_arrest0.59228968
147MP0002736_abnormal_nociception_after0.58702285
148MP0004947_skin_inflammation0.57147800
149MP0000377_abnormal_hair_follicle0.56923195
150MP0009115_abnormal_fat_cell0.56630355
151MP0004883_abnormal_blood_vessel0.55775111
152MP0010678_abnormal_skin_adnexa0.55086922
153MP0008260_abnormal_autophagy0.54569623

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)4.39534029
2Volvulus (HP:0002580)4.38813551
3T lymphocytopenia (HP:0005403)3.81935463
4Subacute progressive viral hepatitis (HP:0006572)3.75197530
5Hepatoblastoma (HP:0002884)3.64812616
6B lymphocytopenia (HP:0010976)3.54690061
7Hypothermia (HP:0002045)3.49915375
8Abnormality of B cell number (HP:0010975)3.44864812
911 pairs of ribs (HP:0000878)3.43369566
10Glioma (HP:0009733)3.42302292
11Acute lymphatic leukemia (HP:0006721)3.41110074
12Thrombocytosis (HP:0001894)3.39503850
13Abnormality of T cell number (HP:0011839)3.30418292
14Birth length less than 3rd percentile (HP:0003561)3.24695184
15Eczematoid dermatitis (HP:0000976)3.20717390
16Viral hepatitis (HP:0006562)3.20243157
17Asymmetry of the thorax (HP:0001555)3.17650093
18Transitional cell carcinoma of the bladder (HP:0006740)3.12880035
19Cutaneous melanoma (HP:0012056)3.11539988
20Panhypogammaglobulinemia (HP:0003139)3.05719980
21Autoimmune hemolytic anemia (HP:0001890)3.02279450
22Bladder neoplasm (HP:0009725)2.98229884
23Bladder carcinoma (HP:0002862)2.98229884
24Pancreatic islet-cell hyperplasia (HP:0004510)2.97649613
25Leiomyosarcoma (HP:0100243)2.95837870
26Uterine leiomyosarcoma (HP:0002891)2.95837870
27Reticulocytopenia (HP:0001896)2.94878372
28Protruding tongue (HP:0010808)2.91357129
29Hematochezia (HP:0002573)2.87975990
30Aplastic anemia (HP:0001915)2.86753322
31Chromsome breakage (HP:0040012)2.85448840
32Abnormality of DNA repair (HP:0003254)2.83651660
33IgM deficiency (HP:0002850)2.81945595
34Recurrent bacterial skin infections (HP:0005406)2.80869244
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79751394
36Prolonged bleeding time (HP:0003010)2.76860846
37Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.75512599
38Intestinal atresia (HP:0011100)2.72139301
39Abnormality of the astrocytes (HP:0100707)2.66986273
40Astrocytoma (HP:0009592)2.66986273
41Recurrent abscess formation (HP:0002722)2.65612051
42Generalized hypopigmentation of hair (HP:0011358)2.64701624
43Decreased circulating renin level (HP:0003351)2.63128829
44Neoplasm of the adrenal gland (HP:0100631)2.60741674
45Gastrointestinal carcinoma (HP:0002672)2.57872747
46Malignant gastrointestinal tract tumors (HP:0006749)2.57872747
47Abnormality of the fingertips (HP:0001211)2.57453385
48Fair hair (HP:0002286)2.55855384
49Neoplasm of the small intestine (HP:0100833)2.54795838
50Unilateral renal agenesis (HP:0000122)2.45847901
51Abnormality of the pancreatic islet cells (HP:0006476)2.42804762
52Abnormality of endocrine pancreas physiology (HP:0012093)2.42804762
53Acute myeloid leukemia (HP:0004808)2.40518436
54Myelodysplasia (HP:0002863)2.37099294
55Limb hypertonia (HP:0002509)2.37045726
56Chest pain (HP:0100749)2.37033925
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.36488354
58Epidermoid cyst (HP:0200040)2.36140531
59Rhabdomyosarcoma (HP:0002859)2.30974123
60Biliary tract neoplasm (HP:0100574)2.30429798
61Lip pit (HP:0100267)2.29977265
62Lymphopenia (HP:0001888)2.29972354
63Micronodular cirrhosis (HP:0001413)2.25890600
64Encephalitis (HP:0002383)2.25386737
65Lymphoma (HP:0002665)2.24987764
66Hypoglycemic seizures (HP:0002173)2.24891407
67Abnormality of chromosome segregation (HP:0002916)2.21636941
68Acute hepatic failure (HP:0006554)2.21251231
69Poikiloderma (HP:0001029)2.19520924
70Broad palm (HP:0001169)2.14485163
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.14264156
72Hyperthyroidism (HP:0000836)2.14216185
73Missing ribs (HP:0000921)2.13986238
74Spontaneous hematomas (HP:0007420)2.11912369
75Optic nerve coloboma (HP:0000588)2.11881275
76Inappropriate behavior (HP:0000719)2.11198178
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10482262
78Uterine neoplasm (HP:0010784)2.07711076
79Colon cancer (HP:0003003)2.07464183
80Severe combined immunodeficiency (HP:0004430)2.05734986
81Medulloblastoma (HP:0002885)2.05303267
82Abnormal platelet volume (HP:0011876)2.04711830
83Abnormality of chromosome stability (HP:0003220)2.04540349
84Stomatitis (HP:0010280)2.04176071
85Entropion (HP:0000621)2.03774677
86Abnormal hair whorl (HP:0010721)2.03143134
87Abnormality of the renal collecting system (HP:0004742)2.02378748
88Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02336482
89Truncal obesity (HP:0001956)2.00869819
90Disinhibition (HP:0000734)2.00654280
91Long eyelashes (HP:0000527)2.00360095
92Basal cell carcinoma (HP:0002671)2.00185059
93Neoplasm of the oral cavity (HP:0100649)1.99697035
94Hyperinsulinemic hypoglycemia (HP:0000825)1.98500583
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.97748656
96Recurrent fungal infections (HP:0002841)1.96757004
97Agitation (HP:0000713)1.96622773
98IgG deficiency (HP:0004315)1.93836258
99Renal cortical cysts (HP:0000803)1.93054605
100Abnormality of the fovea (HP:0000493)1.92555122
101Recurrent viral infections (HP:0004429)1.91967274
102Poor eye contact (HP:0000817)1.91272014
103Abnormality of macrophages (HP:0004311)1.90277004
104Recurrent bronchitis (HP:0002837)1.90210800
105Chronic otitis media (HP:0000389)1.90121141
106Insulin-resistant diabetes mellitus (HP:0000831)1.90085602
107Impaired social interactions (HP:0000735)1.88591831
108Abnormal social behavior (HP:0012433)1.88591831
109Mesomelia (HP:0003027)1.87459773
110Gastrointestinal inflammation (HP:0004386)1.87230839
111Enlarged penis (HP:0000040)1.86500095
112Prominent nose (HP:0000448)1.86286409
113Gastrointestinal infarctions (HP:0005244)1.85902253
114Microvesicular hepatic steatosis (HP:0001414)1.85499409
115Meningitis (HP:0001287)1.84333364
116Growth hormone excess (HP:0000845)1.83995980
117Abnormality of the metopic suture (HP:0005556)1.83720127
118Breast hypoplasia (HP:0003187)1.83606547
119Thyroid carcinoma (HP:0002890)1.82461746
120Papillary thyroid carcinoma (HP:0002895)1.81765218
121Papilledema (HP:0001085)1.81372080
122Visual hallucinations (HP:0002367)1.80912036
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.79949216
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79949216
125Patellar aplasia (HP:0006443)1.79869857
126Combined immunodeficiency (HP:0005387)1.79672399
127Prominent metopic ridge (HP:0005487)1.79228003
128Hypochromic microcytic anemia (HP:0004840)1.78891584
129Renal cell carcinoma (HP:0005584)1.77747477
130Excessive salivation (HP:0003781)1.77705471
131Deep philtrum (HP:0002002)1.77651127
132Nephroblastoma (Wilms tumor) (HP:0002667)1.77604456
133Macroglossia (HP:0000158)1.77164393
134Progressive inability to walk (HP:0002505)1.76472100
135Hypoplastic labia majora (HP:0000059)1.76210353
136Embryonal renal neoplasm (HP:0011794)1.76179552
137Flat occiput (HP:0005469)1.75983708
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75354792
139Short 4th metacarpal (HP:0010044)1.75354792
140Aplasia/Hypoplasia of the patella (HP:0006498)1.72977163
141Inflammation of the large intestine (HP:0002037)1.71908891
142Gingival bleeding (HP:0000225)1.71520930
143Epistaxis (HP:0000421)1.71141954
144Amaurosis fugax (HP:0100576)1.69954436
145Papilloma (HP:0012740)1.69445065
146Verrucae (HP:0200043)1.69445065
147Macroorchidism (HP:0000053)1.69340618
148Abnormality of T cells (HP:0002843)1.69338775
149Abnormality of T cell physiology (HP:0011840)1.68808950
150Abnormal biliary tract morphology (HP:0012440)1.68325793
151Heterochromia iridis (HP:0001100)1.68214780
152Agammaglobulinemia (HP:0004432)1.68192031
153Symptomatic seizures (HP:0011145)1.68191761
154Hamartoma (HP:0010566)1.67941381
155Neoplasm of the thyroid gland (HP:0100031)1.67781421
156Spinal cord lesions (HP:0100561)1.67672612
157Syringomyelia (HP:0003396)1.67672612
158Neoplasm of the colon (HP:0100273)1.66978960
159Thyroiditis (HP:0100646)1.66535137
160Amyotrophic lateral sclerosis (HP:0007354)1.66340239
161Cafe-au-lait spot (HP:0000957)1.64499995
162Fibrous tissue neoplasm (HP:0012316)1.64088891
163Neoplasm of the respiratory system (HP:0100606)1.63987493
164Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61940024
165Abnormality of the prostate (HP:0008775)1.61640870
166Hypoplasia of the fovea (HP:0007750)1.61218110
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.61218110
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.61079517
169Increased mean platelet volume (HP:0011877)1.60945731
170Exotropia (HP:0000577)1.59442087
171Bone marrow hypocellularity (HP:0005528)1.59351064
172Neoplasm of the adrenal cortex (HP:0100641)1.58272418
173Squamous cell carcinoma (HP:0002860)1.57683046
174Colitis (HP:0002583)1.57622545
175Absent thumb (HP:0009777)1.55395140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.24428115
2TGFBR13.18029638
3FLT32.92206284
4CDC72.76101133
5PASK2.59691013
6SRPK12.45069739
7BCR2.36616674
8ACVR1B2.32647313
9CCNB12.31591493
10MAP4K12.26122017
11RIPK42.14815305
12TXK2.13420743
13GRK62.10870415
14KSR12.08086425
15KIT2.02046691
16MKNK11.92596152
17BMPR1B1.79929025
18MKNK21.78171014
19INSRR1.75255208
20CAMKK21.69896709
21HIPK21.66838718
22CDK81.63457380
23FES1.59519074
24CLK11.57058105
25TEC1.55574601
26BRD41.54725286
27TRIM281.51947996
28MAP2K71.51648462
29CDK121.51566191
30AKT31.51408756
31NLK1.49466701
32FGR1.48687204
33PNCK1.42067234
34DYRK31.38457445
35TGFBR21.37467347
36FRK1.33753090
37MST41.33718868
38STK101.33033055
39WEE11.32327660
40EEF2K1.31161657
41MAPK131.31141932
42CSK1.29936710
43BLK1.29904511
44ATR1.28190318
45HCK1.20766456
46BTK1.19907539
47ZAK1.19778826
48RAF11.14721782
49TAOK31.12498646
50KSR21.11608573
51SIK21.11216218
52IRAK41.09816673
53JAK31.07497056
54DAPK11.07137823
55CDK41.06839293
56IKBKE1.04442024
57LYN1.02781429
58MELK1.01261623
59BMPR21.00423075
60PKN21.00310453
61FGFR30.99996524
62VRK10.99262995
63MAP3K20.98853212
64SIK30.93616212
65MAP3K40.93025427
66ERBB30.92908019
67YES10.92352334
68ZAP700.92269156
69CSF1R0.91483686
70EIF2AK30.90746906
71CDK70.89940205
72CAMK1D0.89582491
73LCK0.87709855
74BRSK20.85829931
75STK40.83813071
76MAP3K120.83077207
77IRAK10.82967090
78UHMK10.82920664
79MATK0.81415979
80TTK0.77193637
81SYK0.76369891
82PTK2B0.74342376
83ITK0.73271874
84CDK30.73159405
85MAP3K90.72908494
86MARK30.72389545
87STK380.71894145
88RPS6KB10.69896770
89CDK190.69849359
90CDK60.69437616
91PRKCQ0.69293261
92CDK90.68672191
93LRRK20.67245543
94MAP3K140.66963966
95PLK30.65600673
96IRAK20.64859798
97TSSK60.64249024
98ALK0.63070040
99ATM0.62875323
100STK30.62731577
101STK240.62697768
102RPS6KA40.61813191
103MAP3K100.60270976
104FGFR20.60103899
105WNK30.59408209
106PIM10.58309399
107CAMK40.58007600
108CSNK1G30.56231542
109MAP2K60.56180431
110CAMKK10.55974699
111JAK10.55448392
112NUAK10.55370958
113TYK20.54782636
114SGK20.54748701
115MAPK70.53854718
116CAMK10.53363154
117JAK20.53281587
118TAF10.52941947
119CSNK1A1L0.51911911
120PLK10.51559037
121FGFR10.51551274
122MAP3K50.50301531
123CSNK1G20.48619118
124CHEK10.47698499
125DYRK20.47386561
126CSNK1G10.47203469
127MAP3K130.46390949
128CHUK0.46136367
129CAMK1G0.44517829
130CASK0.44340151
131IRAK30.42868592
132ADRBK10.42802456
133MAPKAPK50.41985896
134MAP2K10.41811284
135NEK90.41535457
136BRSK10.41533572
137MAPK120.41428690
138DMPK0.41226628
139CHEK20.41120505
140PLK20.40989851
141AURKB0.40639424
142CSNK1D0.39734770
143TNK20.39660485
144EIF2AK20.39418152
145EGFR0.38104865
146NEK60.38024957

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.69790339
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.60399982
3Mismatch repair_Homo sapiens_hsa034303.33561560
4Protein export_Homo sapiens_hsa030602.40641850
5Cell cycle_Homo sapiens_hsa041102.34926268
6Base excision repair_Homo sapiens_hsa034102.21218719
7Spliceosome_Homo sapiens_hsa030402.20973797
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.98992389
9Homologous recombination_Homo sapiens_hsa034401.96653965
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74650999
11Fanconi anemia pathway_Homo sapiens_hsa034601.70718981
12Nucleotide excision repair_Homo sapiens_hsa034201.66856593
13Thyroid cancer_Homo sapiens_hsa052161.58264929
14RNA degradation_Homo sapiens_hsa030181.57470998
15Osteoclast differentiation_Homo sapiens_hsa043801.56957762
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56157363
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50328166
18Chemokine signaling pathway_Homo sapiens_hsa040621.49997416
19RNA transport_Homo sapiens_hsa030131.48676225
20Ribosome_Homo sapiens_hsa030101.46430553
21mRNA surveillance pathway_Homo sapiens_hsa030151.42588689
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42080421
23Colorectal cancer_Homo sapiens_hsa052101.41192104
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40564006
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38894093
26Inositol phosphate metabolism_Homo sapiens_hsa005621.36986569
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35699268
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34239138
29Acute myeloid leukemia_Homo sapiens_hsa052211.33864166
30p53 signaling pathway_Homo sapiens_hsa041151.28437348
31Non-homologous end-joining_Homo sapiens_hsa034501.28161513
32Primary immunodeficiency_Homo sapiens_hsa053401.27771990
33Insulin secretion_Homo sapiens_hsa049111.24287952
34Steroid biosynthesis_Homo sapiens_hsa001001.23005052
35N-Glycan biosynthesis_Homo sapiens_hsa005101.22300321
36Renal cell carcinoma_Homo sapiens_hsa052111.22137257
37Choline metabolism in cancer_Homo sapiens_hsa052311.17054665
38Pancreatic cancer_Homo sapiens_hsa052121.14538685
39Shigellosis_Homo sapiens_hsa051311.11994257
40Graft-versus-host disease_Homo sapiens_hsa053321.11872645
41Dorso-ventral axis formation_Homo sapiens_hsa043201.11521528
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10886664
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.10601173
44Long-term potentiation_Homo sapiens_hsa047201.10328725
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.07945030
46Type II diabetes mellitus_Homo sapiens_hsa049301.06474605
47Endometrial cancer_Homo sapiens_hsa052131.03968084
48Pyrimidine metabolism_Homo sapiens_hsa002401.03617121
49One carbon pool by folate_Homo sapiens_hsa006701.02993948
50Taste transduction_Homo sapiens_hsa047421.01883488
51Prostate cancer_Homo sapiens_hsa052151.01863440
52Wnt signaling pathway_Homo sapiens_hsa043100.97910500
53Alcoholism_Homo sapiens_hsa050340.97051882
54Herpes simplex infection_Homo sapiens_hsa051680.94892668
55Prolactin signaling pathway_Homo sapiens_hsa049170.94573673
56Serotonergic synapse_Homo sapiens_hsa047260.93747851
57FoxO signaling pathway_Homo sapiens_hsa040680.91178929
58Leishmaniasis_Homo sapiens_hsa051400.91165063
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90833998
60Selenocompound metabolism_Homo sapiens_hsa004500.90660789
61Viral carcinogenesis_Homo sapiens_hsa052030.89939952
62Oocyte meiosis_Homo sapiens_hsa041140.89826583
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.89195637
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88927422
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.88916918
66Viral myocarditis_Homo sapiens_hsa054160.87992759
67RNA polymerase_Homo sapiens_hsa030200.87431806
68B cell receptor signaling pathway_Homo sapiens_hsa046620.87035369
69Gap junction_Homo sapiens_hsa045400.86565428
70Tuberculosis_Homo sapiens_hsa051520.83914450
71Non-small cell lung cancer_Homo sapiens_hsa052230.83623732
72Chronic myeloid leukemia_Homo sapiens_hsa052200.82070295
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82046145
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79753514
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.79724947
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.77974762
77Platelet activation_Homo sapiens_hsa046110.77650423
78Hematopoietic cell lineage_Homo sapiens_hsa046400.76594285
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.75504923
80HTLV-I infection_Homo sapiens_hsa051660.73232366
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73220654
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72364942
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.71171372
84Autoimmune thyroid disease_Homo sapiens_hsa053200.70897857
85Morphine addiction_Homo sapiens_hsa050320.70641556
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69907852
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69613397
88Epstein-Barr virus infection_Homo sapiens_hsa051690.69511181
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68712172
90mTOR signaling pathway_Homo sapiens_hsa041500.68439372
91Basal transcription factors_Homo sapiens_hsa030220.68085860
92Olfactory transduction_Homo sapiens_hsa047400.68047874
93MAPK signaling pathway_Homo sapiens_hsa040100.68005748
94Regulation of autophagy_Homo sapiens_hsa041400.67057915
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66920946
96Rap1 signaling pathway_Homo sapiens_hsa040150.66077221
97Cholinergic synapse_Homo sapiens_hsa047250.65897524
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65766934
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65557804
100T cell receptor signaling pathway_Homo sapiens_hsa046600.64804773
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64619118
102Glutamatergic synapse_Homo sapiens_hsa047240.63386349
103Glioma_Homo sapiens_hsa052140.63212277
104Adherens junction_Homo sapiens_hsa045200.62376249
105Dopaminergic synapse_Homo sapiens_hsa047280.61433547
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60159172
107Notch signaling pathway_Homo sapiens_hsa043300.59741820
108Hepatitis B_Homo sapiens_hsa051610.59591281
109Apoptosis_Homo sapiens_hsa042100.59382426
110Antigen processing and presentation_Homo sapiens_hsa046120.58966430
111Insulin resistance_Homo sapiens_hsa049310.58611238
112Allograft rejection_Homo sapiens_hsa053300.58076870
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57401044
114Amphetamine addiction_Homo sapiens_hsa050310.57266174
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57202320
116Glucagon signaling pathway_Homo sapiens_hsa049220.56994234
117Estrogen signaling pathway_Homo sapiens_hsa049150.55780105
118MicroRNAs in cancer_Homo sapiens_hsa052060.55664599
119Renin secretion_Homo sapiens_hsa049240.55441113
120Long-term depression_Homo sapiens_hsa047300.55193659
121Insulin signaling pathway_Homo sapiens_hsa049100.54982887
122VEGF signaling pathway_Homo sapiens_hsa043700.54569539
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54445510
124Measles_Homo sapiens_hsa051620.54272558
125ErbB signaling pathway_Homo sapiens_hsa040120.53871430
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52450452
127Pathways in cancer_Homo sapiens_hsa052000.51912897
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51807117
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51612652
130Purine metabolism_Homo sapiens_hsa002300.50909612
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49402502
132Oxytocin signaling pathway_Homo sapiens_hsa049210.49337039
133Melanogenesis_Homo sapiens_hsa049160.49155252
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49001236
135Cocaine addiction_Homo sapiens_hsa050300.48311375
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48261144
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47409329
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46555686
139Influenza A_Homo sapiens_hsa051640.46073944
140Type I diabetes mellitus_Homo sapiens_hsa049400.46015537
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45926042
142Lysine degradation_Homo sapiens_hsa003100.45612649
143Systemic lupus erythematosus_Homo sapiens_hsa053220.45068323
144Legionellosis_Homo sapiens_hsa051340.45045858

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