ZBTB18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.40853429
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70530622
3synaptic vesicle maturation (GO:0016188)5.61800857
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60007156
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40334731
6vocalization behavior (GO:0071625)5.39245305
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.36469414
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.29745220
9layer formation in cerebral cortex (GO:0021819)5.08131990
10exploration behavior (GO:0035640)4.99490999
11positive regulation of synapse maturation (GO:0090129)4.96992871
12regulation of glutamate receptor signaling pathway (GO:1900449)4.92036209
13synaptic vesicle exocytosis (GO:0016079)4.87865884
14glutamate secretion (GO:0014047)4.86769216
15glutamate receptor signaling pathway (GO:0007215)4.84002439
16protein localization to synapse (GO:0035418)4.67044736
17regulation of synaptic vesicle exocytosis (GO:2000300)4.66389380
18cerebellar granule cell differentiation (GO:0021707)4.62331848
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.55878266
20synaptic transmission, glutamatergic (GO:0035249)4.53536687
21neuronal action potential propagation (GO:0019227)4.42639091
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.35480058
23dendritic spine morphogenesis (GO:0060997)4.22866587
24regulation of synaptic vesicle transport (GO:1902803)4.21034003
25regulation of neuronal synaptic plasticity (GO:0048168)4.20199465
26cellular potassium ion homeostasis (GO:0030007)4.16113601
27neuron cell-cell adhesion (GO:0007158)4.13739490
28long-term memory (GO:0007616)4.12293996
29regulation of synapse structural plasticity (GO:0051823)4.11657531
30neurotransmitter-gated ion channel clustering (GO:0072578)4.10051281
31neurotransmitter secretion (GO:0007269)4.06042014
32neuron-neuron synaptic transmission (GO:0007270)4.03019082
33sodium ion export (GO:0071436)3.96923683
34presynaptic membrane assembly (GO:0097105)3.95592408
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94912806
36regulation of dendritic spine morphogenesis (GO:0061001)3.93653920
37L-amino acid import (GO:0043092)3.92797923
38neuron recognition (GO:0008038)3.88462150
39gamma-aminobutyric acid transport (GO:0015812)3.88122084
40dendrite morphogenesis (GO:0048813)3.88023139
41axonal fasciculation (GO:0007413)3.86036981
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85630812
43synaptic vesicle endocytosis (GO:0048488)3.83434759
44proline transport (GO:0015824)3.80533228
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.79356366
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.73586088
47regulation of synapse maturation (GO:0090128)3.69714864
48regulation of postsynaptic membrane potential (GO:0060078)3.68028917
49central nervous system projection neuron axonogenesis (GO:0021952)3.62355883
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.61406138
51cerebellar Purkinje cell differentiation (GO:0021702)3.60996549
52positive regulation of membrane potential (GO:0045838)3.58653575
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58462910
54regulation of synaptic plasticity (GO:0048167)3.55887337
55neuromuscular process controlling balance (GO:0050885)3.54521744
56potassium ion import (GO:0010107)3.52659578
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50732357
58cell communication by electrical coupling (GO:0010644)3.44288938
59auditory behavior (GO:0031223)3.43677200
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.37734243
61activation of protein kinase A activity (GO:0034199)3.34118660
62cerebral cortex radially oriented cell migration (GO:0021799)3.33209492
63cell migration in hindbrain (GO:0021535)3.32533112
64long-term synaptic potentiation (GO:0060291)3.32217889
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31680880
66dendritic spine organization (GO:0097061)3.31491064
67postsynaptic membrane organization (GO:0001941)3.31443475
68regulation of dendritic spine development (GO:0060998)3.31272509
69positive regulation of dendritic spine development (GO:0060999)3.31266796
70regulation of ARF protein signal transduction (GO:0032012)3.30195648
71innervation (GO:0060384)3.28537633
72regulation of neurotransmitter secretion (GO:0046928)3.22758965
73G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22739766
74transmission of nerve impulse (GO:0019226)3.21388967
75establishment of nucleus localization (GO:0040023)3.21351481
76response to pheromone (GO:0019236)3.19107609
77neurotransmitter transport (GO:0006836)3.17350908
78behavioral defense response (GO:0002209)3.17095358
79behavioral fear response (GO:0001662)3.17095358
80cell differentiation in hindbrain (GO:0021533)3.17009393
81amino acid import (GO:0043090)3.15561357
82membrane depolarization (GO:0051899)3.13534093
83long term synaptic depression (GO:0060292)3.12365773
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09538227
85chemosensory behavior (GO:0007635)3.08962170
86vesicle transport along microtubule (GO:0047496)3.06968906
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.06877699
88fear response (GO:0042596)3.06511602
89regulation of vesicle fusion (GO:0031338)3.05278786
90potassium ion homeostasis (GO:0055075)3.03980480
91membrane depolarization during action potential (GO:0086010)3.03736372
92regulation of voltage-gated calcium channel activity (GO:1901385)3.00003345
93positive regulation of neurotransmitter secretion (GO:0001956)2.97467615
94mechanosensory behavior (GO:0007638)2.96960468
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96126517
96central nervous system myelination (GO:0022010)2.95815280
97axon ensheathment in central nervous system (GO:0032291)2.95815280
98cellular sodium ion homeostasis (GO:0006883)2.94727069
99regulation of neurotransmitter levels (GO:0001505)2.94637443
100learning (GO:0007612)2.94264462
101synapse assembly (GO:0007416)2.93891229
102cellular response to electrical stimulus (GO:0071257)2.93301526
103clathrin coat assembly (GO:0048268)2.92480668
104organelle transport along microtubule (GO:0072384)2.91808521
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90821812
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89381348
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89101494
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88742805
109regulation of neurotransmitter transport (GO:0051588)2.87725993
110pyrimidine nucleobase catabolic process (GO:0006208)2.87282659
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86429366
112intraspecies interaction between organisms (GO:0051703)2.85656704
113social behavior (GO:0035176)2.85656704
114neuronal ion channel clustering (GO:0045161)2.84790376
115presynaptic membrane organization (GO:0097090)2.84756935
116negative regulation of dendrite morphogenesis (GO:0050774)2.82135456
117response to parathyroid hormone (GO:0071107)2.78219937
118response to auditory stimulus (GO:0010996)2.68887040
119central nervous system neuron axonogenesis (GO:0021955)2.67697415
120regulation of dendrite development (GO:0050773)2.66908209
121negative regulation of dendrite development (GO:2000171)2.65559107
122regulation of dendrite morphogenesis (GO:0048814)2.65407872
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.64118265
124regulation of Rap GTPase activity (GO:0032317)2.62868386
125cell communication involved in cardiac conduction (GO:0086065)2.62241602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97081390
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99342972
3GBX2_23144817_ChIP-Seq_PC3_Human2.98546681
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96977899
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94614529
6REST_21632747_ChIP-Seq_MESCs_Mouse2.68505705
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67906342
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67906342
9DROSHA_22980978_ChIP-Seq_HELA_Human2.67294089
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.52656481
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49642881
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48491333
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47834767
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42386168
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41628114
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35223971
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.27458406
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26000094
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.25642157
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.21713909
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15556447
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15088516
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13818384
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.11627292
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.05706774
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93994472
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76439874
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74588254
29AR_21572438_ChIP-Seq_LNCaP_Human1.74466887
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65611999
31ZNF274_21170338_ChIP-Seq_K562_Hela1.61494917
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59138513
33SMAD4_21799915_ChIP-Seq_A2780_Human1.53893277
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47645768
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46033886
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45118324
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.44818207
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40924497
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38281873
40KDM2B_26808549_Chip-Seq_K562_Human1.38215546
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.34386321
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.30008259
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29369304
44AR_19668381_ChIP-Seq_PC3_Human1.28675890
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28515948
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28368657
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.25483116
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24849112
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23493768
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23006743
51TP53_16413492_ChIP-PET_HCT116_Human1.22682489
52AR_25329375_ChIP-Seq_VCAP_Human1.22513277
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.21350320
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20553305
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20350800
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20262725
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18170471
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18130738
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17474748
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16493045
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.15337422
62STAT3_23295773_ChIP-Seq_U87_Human1.15276919
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15227821
64P300_19829295_ChIP-Seq_ESCs_Human1.14174111
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13580372
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13548061
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.12177917
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10700910
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10093753
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08395132
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08066719
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07836958
73TCF4_23295773_ChIP-Seq_U87_Human1.04365947
74AHR_22903824_ChIP-Seq_MCF-7_Human1.04020852
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03880122
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03621531
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03586996
78KDM2B_26808549_Chip-Seq_DND41_Human1.03097739
79RNF2_27304074_Chip-Seq_NSC_Mouse1.02622525
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00946599
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00831092
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00831092
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00822146
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00445372
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00338664
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.00242218
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.99691985
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99308330
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.98296638
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97539433
91TAF15_26573619_Chip-Seq_HEK293_Human0.97118191
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97046444
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.96871161
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96236740
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96160588
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95928836
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95518334
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95426020
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95408516
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95371374
101IGF1R_20145208_ChIP-Seq_DFB_Human0.94217664
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.93860855
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.92867011
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.92846687
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92080312
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91737862
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91490214
108KDM2B_26808549_Chip-Seq_REH_Human0.91356325
109RUNX_20019798_ChIP-Seq_JUKART_Human0.91269249
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91212879
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90763790
112RXR_22108803_ChIP-Seq_LS180_Human0.90596397
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89637706
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.88663747
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87927682
116RUNX2_22187159_ChIP-Seq_PCA_Human0.87254785
117TP53_18474530_ChIP-ChIP_U2OS_Human0.85966594
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85251759
119BCAT_22108803_ChIP-Seq_LS180_Human0.85149143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.55262407
2MP0003635_abnormal_synaptic_transmissio4.40272020
3MP0003880_abnormal_central_pattern4.32115487
4MP0004270_analgesia4.14692292
5MP0002063_abnormal_learning/memory/cond3.55323425
6MP0009745_abnormal_behavioral_response3.35090370
7MP0009046_muscle_twitch3.13777345
8MP0002064_seizures3.03574104
9MP0001968_abnormal_touch/_nociception2.83173119
10MP0005423_abnormal_somatic_nervous2.78949434
11MP0002572_abnormal_emotion/affect_behav2.75916960
12MP0002734_abnormal_mechanical_nocicepti2.62255942
13MP0009780_abnormal_chondrocyte_physiolo2.48993176
14MP0002272_abnormal_nervous_system2.43718098
15MP0001440_abnormal_grooming_behavior2.40837359
16MP0000778_abnormal_nervous_system2.38917664
17MP0002735_abnormal_chemical_nociception2.36323402
18MP0008569_lethality_at_weaning2.34223577
19MP0001486_abnormal_startle_reflex2.33600442
20MP0002736_abnormal_nociception_after2.32317699
21MP0003329_amyloid_beta_deposits2.16078427
22MP0002184_abnormal_innervation2.11747495
23MP0002067_abnormal_sensory_capabilities2.10852241
24MP0001501_abnormal_sleep_pattern2.09913196
25MP0004858_abnormal_nervous_system1.99513469
26MP0004885_abnormal_endolymph1.99186522
27MP0002733_abnormal_thermal_nociception1.91967853
28MP0004811_abnormal_neuron_physiology1.89735743
29MP0001970_abnormal_pain_threshold1.76447838
30MP0002557_abnormal_social/conspecific_i1.75526440
31MP0000955_abnormal_spinal_cord1.72240537
32MP0005386_behavior/neurological_phenoty1.69892107
33MP0004924_abnormal_behavior1.69892107
34MP0003879_abnormal_hair_cell1.63954760
35MP0004145_abnormal_muscle_electrophysio1.61475393
36MP0002909_abnormal_adrenal_gland1.57934561
37MP0002066_abnormal_motor_capabilities/c1.49093359
38MP0002882_abnormal_neuron_morphology1.47166272
39MP0000569_abnormal_digit_pigmentation1.46803832
40MP0003633_abnormal_nervous_system1.39795113
41MP0004510_myositis1.37611921
42MP0003787_abnormal_imprinting1.37276326
43MP0002152_abnormal_brain_morphology1.30191135
44MP0003631_nervous_system_phenotype1.24171819
45MP0001984_abnormal_olfaction1.18601273
46MP0001502_abnormal_circadian_rhythm1.17335060
47MP0000604_amyloidosis1.11687844
48MP0003632_abnormal_nervous_system1.08781398
49MP0002638_abnormal_pupillary_reflex1.08770508
50MP0004742_abnormal_vestibular_system1.08592689
51MP0005187_abnormal_penis_morphology1.07896482
52MP0002822_catalepsy0.99167124
53MP0006276_abnormal_autonomic_nervous0.98425923
54MP0010234_abnormal_vibrissa_follicle0.98309287
55MP0004484_altered_response_of0.93278963
56MP0000751_myopathy0.93072614
57MP0004142_abnormal_muscle_tone0.92538395
58MP0002069_abnormal_eating/drinking_beha0.91265086
59MP0003122_maternal_imprinting0.89918440
60MP0003075_altered_response_to0.89559039
61MP0000749_muscle_degeneration0.87622864
62MP0002229_neurodegeneration0.86469855
63MP0005645_abnormal_hypothalamus_physiol0.85520137
64MP0005409_darkened_coat_color0.85489464
65MP0002234_abnormal_pharynx_morphology0.84306505
66MP0003123_paternal_imprinting0.84053513
67MP0003690_abnormal_glial_cell0.82851104
68MP0004215_abnormal_myocardial_fiber0.82556551
69MP0005499_abnormal_olfactory_system0.82206616
70MP0005394_taste/olfaction_phenotype0.82206616
71MP0003634_abnormal_glial_cell0.81968933
72MP0008874_decreased_physiological_sensi0.81763283
73MP0001177_atelectasis0.79439183
74MP0003861_abnormal_nervous_system0.79353070
75MP0008961_abnormal_basal_metabolism0.77956827
76MP0008872_abnormal_physiological_respon0.77406992
77MP0001963_abnormal_hearing_physiology0.75753094
78MP0005535_abnormal_body_temperature0.75181603
79MP0005646_abnormal_pituitary_gland0.75133127
80MP0000920_abnormal_myelination0.75102020
81MP0004233_abnormal_muscle_weight0.74511128
82MP0004085_abnormal_heartbeat0.73108474
83MP0002249_abnormal_larynx_morphology0.72866375
84MP0003045_fibrosis0.72757165
85MP0004130_abnormal_muscle_cell0.71926090
86MP0002837_dystrophic_cardiac_calcinosis0.71299244
87MP0001348_abnormal_lacrimal_gland0.70947753
88MP0003137_abnormal_impulse_conducting0.69337297
89MP0002752_abnormal_somatic_nervous0.67586473
90MP0000747_muscle_weakness0.67563781
91MP0005551_abnormal_eye_electrophysiolog0.66799259
92MP0005248_abnormal_Harderian_gland0.65277358
93MP0000631_abnormal_neuroendocrine_gland0.64252091
94MP0000759_abnormal_skeletal_muscle0.62841160
95MP0005388_respiratory_system_phenotype0.62002707
96MP0002133_abnormal_respiratory_system0.62002707
97MP0002653_abnormal_ependyma_morphology0.61695386
98MP0001905_abnormal_dopamine_level0.59775578
99MP0003303_peritoneal_inflammation0.59337429
100MP0010769_abnormal_survival0.58983155
101MP0005620_abnormal_muscle_contractility0.58140628
102MP0001188_hyperpigmentation0.58121263
103MP0005167_abnormal_blood-brain_barrier0.57495109
104MP0003121_genomic_imprinting0.57052349
105MP0001346_abnormal_lacrimal_gland0.56842923
106MP0002106_abnormal_muscle_physiology0.56427678
107MP0010768_mortality/aging0.54874654
108MP0001485_abnormal_pinna_reflex0.54428176
109MP0002082_postnatal_lethality0.54383403
110MP0010770_preweaning_lethality0.54383403
111MP0010386_abnormal_urinary_bladder0.53437649
112MP0001299_abnormal_eye_distance/0.53390641
113MP0004087_abnormal_muscle_fiber0.51817718
114MP0003956_abnormal_body_size0.51439450
115MP0003172_abnormal_lysosome_physiology0.50855946
116MP0005623_abnormal_meninges_morphology0.50433142
117MP0004036_abnormal_muscle_relaxation0.50403473
118MP0001986_abnormal_taste_sensitivity0.50048904
119MP0001943_abnormal_respiration0.49221373
120MP0002090_abnormal_vision0.49150755
121MP0006292_abnormal_olfactory_placode0.48878036

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.63645756
2Myokymia (HP:0002411)5.92249805
3Visual hallucinations (HP:0002367)5.45530847
4Focal seizures (HP:0007359)5.27342543
5Action tremor (HP:0002345)4.88038826
6Progressive cerebellar ataxia (HP:0002073)4.80142010
7Epileptic encephalopathy (HP:0200134)4.52015940
8Atonic seizures (HP:0010819)4.05319836
9Broad-based gait (HP:0002136)3.96074214
10Febrile seizures (HP:0002373)3.86609341
11Absence seizures (HP:0002121)3.82317478
12Supranuclear gaze palsy (HP:0000605)3.79382142
13Gaze-evoked nystagmus (HP:0000640)3.72102765
14Poor eye contact (HP:0000817)3.72077997
15Dysdiadochokinesis (HP:0002075)3.50355114
16Abnormality of the lower motor neuron (HP:0002366)3.49760824
17Hyperventilation (HP:0002883)3.39875131
18Dialeptic seizures (HP:0011146)3.37986694
19Mutism (HP:0002300)3.36940120
20Generalized tonic-clonic seizures (HP:0002069)3.36816880
21Amyotrophic lateral sclerosis (HP:0007354)3.34373976
22Impaired smooth pursuit (HP:0007772)3.32237725
23Impaired social interactions (HP:0000735)3.31982056
24Abnormal social behavior (HP:0012433)3.31982056
25Genetic anticipation (HP:0003743)3.27757146
26Excessive salivation (HP:0003781)3.25591526
27Drooling (HP:0002307)3.25591526
28Dysmetria (HP:0001310)3.21080334
29Abnormality of binocular vision (HP:0011514)3.19497921
30Diplopia (HP:0000651)3.19497921
31Hemiparesis (HP:0001269)3.16317894
32Impaired vibration sensation in the lower limbs (HP:0002166)3.16235689
33Cerebral inclusion bodies (HP:0100314)3.11609960
34Truncal ataxia (HP:0002078)3.07598590
35Intention tremor (HP:0002080)3.02100712
36Depression (HP:0000716)3.02021871
37Abnormality of ocular smooth pursuit (HP:0000617)3.01472512
38Dysmetric saccades (HP:0000641)2.97561982
39Amblyopia (HP:0000646)2.91823212
40Difficulty running (HP:0009046)2.90736767
41Papilledema (HP:0001085)2.88321501
42Neurofibrillary tangles (HP:0002185)2.87791373
43Scanning speech (HP:0002168)2.86101399
44Urinary bladder sphincter dysfunction (HP:0002839)2.80262280
45Inappropriate behavior (HP:0000719)2.79941578
46Abnormality of the corticospinal tract (HP:0002492)2.75877276
47Megalencephaly (HP:0001355)2.73291152
48Postural instability (HP:0002172)2.68596243
49Ankle clonus (HP:0011448)2.68136403
50Stereotypic behavior (HP:0000733)2.62868933
51Hemiplegia (HP:0002301)2.61641184
52Urinary urgency (HP:0000012)2.61077617
53Anxiety (HP:0000739)2.60299371
54Obstructive sleep apnea (HP:0002870)2.55677175
55Insidious onset (HP:0003587)2.48264658
56Termporal pattern (HP:0011008)2.48264658
57Fetal akinesia sequence (HP:0001989)2.43170238
58Epileptiform EEG discharges (HP:0011182)2.42956341
59Lower limb asymmetry (HP:0100559)2.42098511
60Apathy (HP:0000741)2.41610567
61Absent speech (HP:0001344)2.40447260
62Tetraplegia (HP:0002445)2.40249581
63Thickened helices (HP:0000391)2.37784365
64Abnormal eating behavior (HP:0100738)2.35290954
65Exercise-induced myalgia (HP:0003738)2.32767426
66EEG with generalized epileptiform discharges (HP:0011198)2.31057292
67Spastic gait (HP:0002064)2.29573174
68Hyporeflexia of lower limbs (HP:0002600)2.28719596
69Pointed chin (HP:0000307)2.27276261
70Status epilepticus (HP:0002133)2.26867880
71Subaortic stenosis (HP:0001682)2.23642173
72Abnormality of the left ventricular outflow tract (HP:0011103)2.23642173
73Insomnia (HP:0100785)2.23471560
74Aqueductal stenosis (HP:0002410)2.22603512
75Progressive inability to walk (HP:0002505)2.22459446
76Hypsarrhythmia (HP:0002521)2.22060076
77Muscle fiber inclusion bodies (HP:0100299)2.20448607
78Bradykinesia (HP:0002067)2.20179601
79Impaired vibratory sensation (HP:0002495)2.19247243
80Annular pancreas (HP:0001734)2.17499365
81Limb dystonia (HP:0002451)2.17085989
82Abnormality of salivation (HP:0100755)2.13343614
83Diminished motivation (HP:0000745)2.12506735
84Agitation (HP:0000713)2.09087928
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08102294
86Gait ataxia (HP:0002066)2.08050305
87Nemaline bodies (HP:0003798)2.07891062
88Sleep apnea (HP:0010535)2.07012406
89Ventricular fibrillation (HP:0001663)2.06785890
90EMG: neuropathic changes (HP:0003445)2.03386707
91Bundle branch block (HP:0011710)2.02843871
92Akinesia (HP:0002304)1.98018850
93Neuronal loss in central nervous system (HP:0002529)1.95478558
94Lower limb muscle weakness (HP:0007340)1.94196843
95Muscle fiber splitting (HP:0003555)1.93395067
96Clonus (HP:0002169)1.93222913
97Deeply set eye (HP:0000490)1.92075081
98Torticollis (HP:0000473)1.88535894
99Peripheral hypomyelination (HP:0007182)1.88449968
100Intellectual disability, profound (HP:0002187)1.88294699
101Prolonged QT interval (HP:0001657)1.87207887
102Focal dystonia (HP:0004373)1.86467270
103Inability to walk (HP:0002540)1.86203618
104Protruding tongue (HP:0010808)1.86185584
105Abnormality of saccadic eye movements (HP:0000570)1.85324281
106Morphological abnormality of the pyramidal tract (HP:0002062)1.85136338
107Incomplete penetrance (HP:0003829)1.81075428
108Disinhibition (HP:0000734)1.80375599
109Generalized myoclonic seizures (HP:0002123)1.79720898
110Macroorchidism (HP:0000053)1.78985460
111Sporadic (HP:0003745)1.78965806
112Rapidly progressive (HP:0003678)1.78543508
113Postural tremor (HP:0002174)1.78276554
114Rigidity (HP:0002063)1.78241274
115Pachygyria (HP:0001302)1.77544886
116Lower limb amyotrophy (HP:0007210)1.74149646
117Horizontal nystagmus (HP:0000666)1.74058927
118Abnormal EKG (HP:0003115)1.73333959
119Psychosis (HP:0000709)1.73029085
120Intellectual disability, severe (HP:0010864)1.71729998
121Hepatoblastoma (HP:0002884)1.71190409
122Autism (HP:0000717)1.70890815
123Frequent falls (HP:0002359)1.70777201
124Spinal canal stenosis (HP:0003416)1.69038850
125Abnormality of the foot musculature (HP:0001436)1.66846642
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65735392
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.65735392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.62447392
2NTRK34.06564006
3EPHA43.86267397
4MAP3K93.73405423
5MAP3K42.90658284
6MINK12.72858566
7DAPK22.70389533
8RIPK42.61162998
9PAK62.31257717
10CAMKK12.28558853
11MAP2K72.18119765
12SIK22.09851916
13KSR22.00677055
14KSR11.92678629
15NTRK21.92333606
16MAP2K41.89104312
17PRKD31.73897627
18CAMKK21.55966348
19DAPK11.52265188
20CDK51.51167383
21PLK21.42387525
22PRPF4B1.38178993
23PHKG21.35529754
24PHKG11.35529754
25RIPK11.34468802
26STK381.32373533
27PNCK1.32370004
28MAPK131.32232706
29NTRK11.30770998
30TYRO31.27544412
31PRKCG1.23480659
32OBSCN1.12348007
33MAP3K121.09732553
34GRK51.09705178
35MAP3K21.06533961
36STK111.06430440
37TNIK1.03150980
38CDK191.02508400
39RET0.96130298
40MAP3K130.95145329
41IRAK20.95067235
42CASK0.93227595
43LATS20.91696049
44DYRK1A0.90814670
45CDK150.89124425
46MAPK70.88714716
47CDK180.88174499
48BMPR20.87970378
49TAOK10.86697330
50PTK2B0.86651818
51FES0.86463981
52ALK0.86119805
53CAMK10.84759529
54CAMK2A0.84529342
55EPHA30.82873052
56CDK140.82414581
57TNK20.82026670
58YES10.81950717
59ERBB30.81670578
60PDK10.81475995
61UHMK10.77396177
62CDK11A0.76695009
63SGK10.76364991
64CAMK2B0.75450747
65SGK30.74145044
66RAF10.73749590
67SGK2230.72912066
68SGK4940.72912066
69CAMK1G0.72296385
70SGK20.71885928
71TRIB30.71782769
72CSNK1G20.70440588
73MAP3K100.70364722
74PRKCH0.70124064
75MARK20.69664334
76PRKCZ0.67712288
77MAPK120.67605188
78PDPK10.65535911
79PAK30.62871870
80MAP3K70.59458791
81DMPK0.58177262
82MAP3K60.57043612
83FYN0.57034164
84WNK10.54910314
85JAK20.52511270
86LMTK20.52265209
87SCYL20.50881897
88NEK60.50745265
89CAMK40.49552971
90RPS6KA30.49500041
91FGR0.49308263
92PINK10.46696035
93MAPK40.45273955
94DYRK1B0.44735486
95CAMK1D0.44588124
96MAP3K10.44142698
97ARAF0.41066682
98PKN10.41066173
99FGFR30.39171697
100CDC42BPA0.38423385
101MAPK100.38167415
102MAP2K30.37717764
103MOS0.37469494
104CCNB10.36696379
105FGFR20.36098361
106RPS6KA20.35713119
107BLK0.35444381
108ERBB20.34022794
109SYK0.33656690
110OXSR10.33581155
111SIK30.33445255
112PRKCE0.32501557
113ROCK20.30764890
114PKN20.29720573
115MAP2K10.28640970
116CAMK2G0.28509266
117PRKCB0.28241251
118PRKG10.27800426
119SRC0.25566794
120ICK0.25473201

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50399933
2Long-term potentiation_Homo sapiens_hsa047202.99153833
3Glutamatergic synapse_Homo sapiens_hsa047242.69598204
4Circadian entrainment_Homo sapiens_hsa047132.66737413
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57877498
6Synaptic vesicle cycle_Homo sapiens_hsa047212.46924034
7GABAergic synapse_Homo sapiens_hsa047272.30300102
8Amphetamine addiction_Homo sapiens_hsa050312.29349271
9Morphine addiction_Homo sapiens_hsa050322.21902245
10Olfactory transduction_Homo sapiens_hsa047402.20298141
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19711680
12Salivary secretion_Homo sapiens_hsa049702.19249727
13Dopaminergic synapse_Homo sapiens_hsa047282.05982566
14Long-term depression_Homo sapiens_hsa047301.95394476
15Gastric acid secretion_Homo sapiens_hsa049711.92976588
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87003107
17Cholinergic synapse_Homo sapiens_hsa047251.82182892
18Insulin secretion_Homo sapiens_hsa049111.70788995
19Oxytocin signaling pathway_Homo sapiens_hsa049211.70727869
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67269482
21Taste transduction_Homo sapiens_hsa047421.64334208
22Renin secretion_Homo sapiens_hsa049241.63079074
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59398826
24Calcium signaling pathway_Homo sapiens_hsa040201.51663255
25GnRH signaling pathway_Homo sapiens_hsa049121.47453383
26Type II diabetes mellitus_Homo sapiens_hsa049301.39145002
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37806541
28Glioma_Homo sapiens_hsa052141.35790540
29Gap junction_Homo sapiens_hsa045401.34753532
30Estrogen signaling pathway_Homo sapiens_hsa049151.32813043
31Serotonergic synapse_Homo sapiens_hsa047261.32128305
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29876858
33cAMP signaling pathway_Homo sapiens_hsa040241.27172343
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26936967
35Axon guidance_Homo sapiens_hsa043601.26129384
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18699281
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16682023
38Cocaine addiction_Homo sapiens_hsa050301.13073691
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11518765
40ErbB signaling pathway_Homo sapiens_hsa040121.10706100
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06298810
42Melanogenesis_Homo sapiens_hsa049161.03861388
43VEGF signaling pathway_Homo sapiens_hsa043701.00345270
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95935092
45Pancreatic secretion_Homo sapiens_hsa049720.95633806
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.94697091
47Choline metabolism in cancer_Homo sapiens_hsa052310.91900069
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89694940
49Dorso-ventral axis formation_Homo sapiens_hsa043200.89453653
50Oocyte meiosis_Homo sapiens_hsa041140.88615011
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87044909
52Nitrogen metabolism_Homo sapiens_hsa009100.86955974
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.85138005
54Thyroid hormone synthesis_Homo sapiens_hsa049180.84995129
55mTOR signaling pathway_Homo sapiens_hsa041500.83578950
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.82755312
57Osteoclast differentiation_Homo sapiens_hsa043800.82713514
58Endometrial cancer_Homo sapiens_hsa052130.76376804
59MAPK signaling pathway_Homo sapiens_hsa040100.76243599
60FoxO signaling pathway_Homo sapiens_hsa040680.72281180
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69995586
62Non-small cell lung cancer_Homo sapiens_hsa052230.69192794
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68323586
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67599475
65Dilated cardiomyopathy_Homo sapiens_hsa054140.67335599
66T cell receptor signaling pathway_Homo sapiens_hsa046600.66878285
67Glucagon signaling pathway_Homo sapiens_hsa049220.66007230
68Collecting duct acid secretion_Homo sapiens_hsa049660.65465261
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64212965
70Chronic myeloid leukemia_Homo sapiens_hsa052200.64033920
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.63475115
72Acute myeloid leukemia_Homo sapiens_hsa052210.60463392
73Inositol phosphate metabolism_Homo sapiens_hsa005620.60413227
74Cardiac muscle contraction_Homo sapiens_hsa042600.60011538
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59480386
76Renal cell carcinoma_Homo sapiens_hsa052110.59022134
77Rap1 signaling pathway_Homo sapiens_hsa040150.58645668
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58520834
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58200136
80Colorectal cancer_Homo sapiens_hsa052100.56652430
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55699444
82Ras signaling pathway_Homo sapiens_hsa040140.54444784
83Bile secretion_Homo sapiens_hsa049760.52943394
84Phototransduction_Homo sapiens_hsa047440.52277502
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51159881
86AMPK signaling pathway_Homo sapiens_hsa041520.50909759
87Tuberculosis_Homo sapiens_hsa051520.50896932
88Chemokine signaling pathway_Homo sapiens_hsa040620.50489251
89African trypanosomiasis_Homo sapiens_hsa051430.50416442
90Endocytosis_Homo sapiens_hsa041440.50000988
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48679365
92Wnt signaling pathway_Homo sapiens_hsa043100.48010016
93Pancreatic cancer_Homo sapiens_hsa052120.47999567
94Insulin signaling pathway_Homo sapiens_hsa049100.47887626
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47712505
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.46996293
97B cell receptor signaling pathway_Homo sapiens_hsa046620.45837721
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45517981
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44362539
100Notch signaling pathway_Homo sapiens_hsa043300.42350882
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42070307
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41313205
103Circadian rhythm_Homo sapiens_hsa047100.39887391
104Platelet activation_Homo sapiens_hsa046110.39825797
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38952325
106Prolactin signaling pathway_Homo sapiens_hsa049170.36969850
107Alcoholism_Homo sapiens_hsa050340.35957437
108HIF-1 signaling pathway_Homo sapiens_hsa040660.35618356
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.34683422
110Prion diseases_Homo sapiens_hsa050200.32214268
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30735094
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30575385
113Vibrio cholerae infection_Homo sapiens_hsa051100.30131327

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