ZBTB20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.34057694
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.33225311
3serotonin metabolic process (GO:0042428)4.04774226
4glutamate receptor signaling pathway (GO:0007215)3.83291620
5gamma-aminobutyric acid transport (GO:0015812)3.78894295
6presynaptic membrane assembly (GO:0097105)3.72929414
7primary amino compound metabolic process (GO:1901160)3.62887149
8synaptic transmission, glutamatergic (GO:0035249)3.58000187
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51307555
10central nervous system projection neuron axonogenesis (GO:0021952)3.49359798
11neuron cell-cell adhesion (GO:0007158)3.46312782
12postsynaptic membrane organization (GO:0001941)3.44075202
13limb bud formation (GO:0060174)3.39207996
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32805072
15regulation of pigment cell differentiation (GO:0050932)3.29848312
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23640145
17response to pheromone (GO:0019236)3.15787554
18presynaptic membrane organization (GO:0097090)3.15351661
19chemosensory behavior (GO:0007635)3.15253727
20neuron recognition (GO:0008038)3.13617600
21vocalization behavior (GO:0071625)3.10282496
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.08799087
23regulation of axon extension involved in axon guidance (GO:0048841)3.06470877
24axonal fasciculation (GO:0007413)3.06338151
25interkinetic nuclear migration (GO:0022027)3.05119569
26sulfation (GO:0051923)3.04522960
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03725003
28regulation of glutamate receptor signaling pathway (GO:1900449)3.03692919
29startle response (GO:0001964)3.02478757
30auditory behavior (GO:0031223)3.02383474
31cerebral cortex radially oriented cell migration (GO:0021799)3.00973828
32embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00688566
33membrane depolarization during action potential (GO:0086010)2.99634288
34detection of calcium ion (GO:0005513)2.98441984
35behavioral fear response (GO:0001662)2.95752005
36behavioral defense response (GO:0002209)2.95752005
37positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95604520
38indole-containing compound metabolic process (GO:0042430)2.94821110
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94424844
40cerebellar granule cell differentiation (GO:0021707)2.94315771
41regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93105150
42central nervous system neuron axonogenesis (GO:0021955)2.91784461
43axon ensheathment in central nervous system (GO:0032291)2.88105734
44central nervous system myelination (GO:0022010)2.88105734
45protein localization to synapse (GO:0035418)2.85668258
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.85177041
47neuron-neuron synaptic transmission (GO:0007270)2.85067609
48neuronal action potential (GO:0019228)2.84858534
49pyrimidine nucleobase catabolic process (GO:0006208)2.84537667
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84362870
51neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.84075674
52otic vesicle formation (GO:0030916)2.83203664
53facial nerve structural organization (GO:0021612)2.80661441
54dendrite morphogenesis (GO:0048813)2.79376352
55neurotransmitter-gated ion channel clustering (GO:0072578)2.78884945
56regulation of axon guidance (GO:1902667)2.78368215
57ovulation cycle (GO:0042698)2.77223268
58reflex (GO:0060004)2.77016555
59cranial nerve structural organization (GO:0021604)2.76471627
60regulation of sarcomere organization (GO:0060297)2.75827760
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75235345
62somite development (GO:0061053)2.73773383
63regulation of action potential (GO:0098900)2.72893945
64cell proliferation in forebrain (GO:0021846)2.72463090
65negative regulation of translation, ncRNA-mediated (GO:0040033)2.71270869
66regulation of translation, ncRNA-mediated (GO:0045974)2.71270869
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71270869
68synaptic vesicle endocytosis (GO:0048488)2.71196238
69positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.71074956
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69263736
71photoreceptor cell differentiation (GO:0046530)2.69189170
72eye photoreceptor cell differentiation (GO:0001754)2.69189170
73spinal cord motor neuron differentiation (GO:0021522)2.69028944
74fear response (GO:0042596)2.66869823
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66487193
76transmission of nerve impulse (GO:0019226)2.65044136
77limb development (GO:0060173)2.65020009
78appendage development (GO:0048736)2.65020009
79negative regulation of systemic arterial blood pressure (GO:0003085)2.63498914
80response to epinephrine (GO:0071871)2.63059826
81indolalkylamine metabolic process (GO:0006586)2.62462406
82urinary tract smooth muscle contraction (GO:0014848)2.62259815
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.62201690
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61677872
85histone H3-K4 trimethylation (GO:0080182)2.61207529
86action potential (GO:0001508)2.60996083
87calcium ion import (GO:0070509)2.60674064
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60420118
89indole-containing compound catabolic process (GO:0042436)2.59958361
90indolalkylamine catabolic process (GO:0046218)2.59958361
91tryptophan catabolic process (GO:0006569)2.59958361
92cilium or flagellum-dependent cell motility (GO:0001539)2.59130307
93dendrite development (GO:0016358)2.58519494
94regulation of axon regeneration (GO:0048679)2.56689902
95regulation of neuron projection regeneration (GO:0070570)2.56689902
96positive regulation of dendritic spine development (GO:0060999)2.56234308
97multicellular organismal movement (GO:0050879)2.56158571
98musculoskeletal movement (GO:0050881)2.56158571
99venous blood vessel morphogenesis (GO:0048845)2.55893281
100positive regulation of potassium ion transmembrane transport (GO:1901381)2.54883143
101long-term memory (GO:0007616)2.54568287
102adult heart development (GO:0007512)2.54552338
103cellular response to epinephrine stimulus (GO:0071872)2.52170230
104kidney morphogenesis (GO:0060993)2.51279750
105cAMP catabolic process (GO:0006198)2.51147683
106adrenergic receptor signaling pathway (GO:0071875)2.50551849
107prostate gland growth (GO:0060736)2.50396928
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.50360649
109negative regulation of protein localization to cell surface (GO:2000009)2.49474101
110regulation of synapse assembly (GO:0051963)2.48771102
111regulation of respiratory system process (GO:0044065)2.48770042
112negative regulation of astrocyte differentiation (GO:0048712)2.48564025
113hindbrain development (GO:0030902)2.46930649
114anatomical structure arrangement (GO:0048532)2.46669684
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46583879
116behavioral response to ethanol (GO:0048149)2.46143966
117mechanosensory behavior (GO:0007638)2.45340486
118regulation of postsynaptic membrane potential (GO:0060078)2.45196924
119positive regulation of action potential (GO:0045760)2.44717020
120positive regulation of fatty acid oxidation (GO:0046321)2.44214668
121cell communication by electrical coupling (GO:0010644)2.43757077
122positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.43526743
123neuromuscular synaptic transmission (GO:0007274)2.43220308
124membrane depolarization (GO:0051899)2.43042113
125metanephric nephron tubule development (GO:0072234)2.42669347
126metanephric tubule development (GO:0072170)2.42669347
127nucleus localization (GO:0051647)2.42405399
128dendritic spine morphogenesis (GO:0060997)2.42362995
129cytoplasmic mRNA processing body assembly (GO:0033962)2.42331080
130nucleobase catabolic process (GO:0046113)2.42022296
131cochlea development (GO:0090102)2.41630021
132regulation of cell communication by electrical coupling (GO:0010649)2.40178222
133neuronal stem cell maintenance (GO:0097150)2.40053389
134epithelial cilium movement (GO:0003351)2.39940728
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39261450
136establishment of nucleus localization (GO:0040023)2.38695718
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38154353
138short-term memory (GO:0007614)2.37978297
139positive regulation of cation channel activity (GO:2001259)2.37973475
140cyclic nucleotide catabolic process (GO:0009214)2.36799850
141synapse assembly (GO:0007416)2.36745260
142peristalsis (GO:0030432)2.36587038
143retinal ganglion cell axon guidance (GO:0031290)2.36325146
144nephron epithelium morphogenesis (GO:0072088)2.35927173
145nephron tubule morphogenesis (GO:0072078)2.35927173
146cilium movement (GO:0003341)2.35699760
147spinal cord development (GO:0021510)2.34958780
148positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34868196
149regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34791470
150renal tubule morphogenesis (GO:0061333)2.34471920
151positive regulation of synapse assembly (GO:0051965)2.33900702
152positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33812057
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.33714040
154response to auditory stimulus (GO:0010996)2.31777113
155regulation of cardiac muscle cell contraction (GO:0086004)2.31696491
156regulation of dendritic spine morphogenesis (GO:0061001)2.31463969
157locomotory exploration behavior (GO:0035641)2.31149283
158regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30487826
159positive regulation of cardiac muscle cell differentiation (GO:2000727)2.25776414
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25401023
161detection of light stimulus involved in visual perception (GO:0050908)2.25341984
162detection of light stimulus involved in sensory perception (GO:0050962)2.25341984
163regulation of membrane repolarization (GO:0060306)2.24214453
164cerebellar Purkinje cell differentiation (GO:0021702)2.24199024
165fucose catabolic process (GO:0019317)2.23320895
166L-fucose metabolic process (GO:0042354)2.23320895
167L-fucose catabolic process (GO:0042355)2.23320895
168protein polyglutamylation (GO:0018095)2.23125000
169cellular response to sterol (GO:0036315)2.22742051
170water-soluble vitamin biosynthetic process (GO:0042364)2.22054379
171artery development (GO:0060840)2.21880723
172kynurenine metabolic process (GO:0070189)2.20816646
173positive regulation of sodium ion transmembrane transport (GO:1902307)2.20663416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28551348
2GBX2_23144817_ChIP-Seq_PC3_Human3.83499897
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49754414
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48340421
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43517642
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39262294
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.31813228
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16273588
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.16058204
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15992158
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06730449
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06730449
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05274166
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00780209
15* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99504095
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97431131
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95059612
18AR_21572438_ChIP-Seq_LNCaP_Human1.94040160
19* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89140551
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87051969
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84410191
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.83846636
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83195111
24DROSHA_22980978_ChIP-Seq_HELA_Human1.81908889
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79288104
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.79200400
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78831129
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78747428
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76667153
30P300_19829295_ChIP-Seq_ESCs_Human1.75987258
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.74263063
32* PIAS1_25552417_ChIP-Seq_VCAP_Human1.72957742
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72644369
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71392084
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70288764
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69019049
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.64942652
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62801395
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62362452
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.53292072
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.51801761
42TAF15_26573619_Chip-Seq_HEK293_Human1.50841053
43TP53_16413492_ChIP-PET_HCT116_Human1.49255755
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48147750
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47124339
46* STAT3_23295773_ChIP-Seq_U87_Human1.46038421
47BCAT_22108803_ChIP-Seq_LS180_Human1.45275956
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43748059
49IGF1R_20145208_ChIP-Seq_DFB_Human1.43691361
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42414964
51FUS_26573619_Chip-Seq_HEK293_Human1.41923741
52AR_25329375_ChIP-Seq_VCAP_Human1.41087546
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40870066
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40259703
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39326582
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39234368
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.38914568
58RNF2_27304074_Chip-Seq_NSC_Mouse1.37392279
59ZNF274_21170338_ChIP-Seq_K562_Hela1.34220102
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33790673
61AHR_22903824_ChIP-Seq_MCF-7_Human1.33625999
62TP53_18474530_ChIP-ChIP_U2OS_Human1.32801387
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32015703
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32015703
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31984533
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.31286576
67* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30925636
68REST_21632747_ChIP-Seq_MESCs_Mouse1.30432496
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29586129
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29550040
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29462846
72CBP_20019798_ChIP-Seq_JUKART_Human1.29462846
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.29434452
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27359295
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.27075640
76* TCF4_23295773_ChIP-Seq_U87_Human1.25939973
77ER_23166858_ChIP-Seq_MCF-7_Human1.24789061
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23478838
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.20829521
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20405959
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19296972
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18769384
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18376743
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18300415
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17429340
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.16557674
87P53_22387025_ChIP-Seq_ESCs_Mouse1.15832576
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15443587
89KDM2B_26808549_Chip-Seq_REH_Human1.14829814
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.14082245
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12466456
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.11828809
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11167235
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10453311
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.10256834
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.10182395
97* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09175078
98* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09175078
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08992973
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08659851
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08395877
102TCF4_22108803_ChIP-Seq_LS180_Human1.07850001
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06731214
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06629511
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.06047504
106* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05962313
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05928537
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.05925234
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05803692
110EWS_26573619_Chip-Seq_HEK293_Human1.04699693
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.04636944
112* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04560102
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03763675
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.02379310
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01459104
116VDR_22108803_ChIP-Seq_LS180_Human1.00411901
117AR_19668381_ChIP-Seq_PC3_Human1.00402866
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99100910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.77064410
2MP0003880_abnormal_central_pattern3.39222268
3MP0000569_abnormal_digit_pigmentation2.99321500
4MP0006292_abnormal_olfactory_placode2.55995083
5MP0003635_abnormal_synaptic_transmissio2.46404367
6MP0001188_hyperpigmentation2.45267144
7MP0005409_darkened_coat_color2.31001247
8MP0003646_muscle_fatigue2.30925780
9MP0003195_calcinosis2.28138096
10MP0004270_analgesia2.23902724
11MP0000778_abnormal_nervous_system2.13133035
12MP0003136_yellow_coat_color2.06303926
13MP0009745_abnormal_behavioral_response2.05035671
14MP0002837_dystrophic_cardiac_calcinosis2.02858496
15MP0005645_abnormal_hypothalamus_physiol2.01908034
16MP0002063_abnormal_learning/memory/cond1.97593945
17MP0001299_abnormal_eye_distance/1.97404084
18MP0001486_abnormal_startle_reflex1.96785240
19MP0005646_abnormal_pituitary_gland1.94534988
20MP0002572_abnormal_emotion/affect_behav1.90542376
21MP0002272_abnormal_nervous_system1.90275171
22MP0004145_abnormal_muscle_electrophysio1.88811692
23MP0002735_abnormal_chemical_nociception1.86196317
24MP0000751_myopathy1.83357185
25MP0005171_absent_coat_pigmentation1.82458574
26MP0006276_abnormal_autonomic_nervous1.80054412
27MP0003283_abnormal_digestive_organ1.75512151
28MP0002064_seizures1.71178855
29MP0005503_abnormal_tendon_morphology1.70665422
30MP0002067_abnormal_sensory_capabilities1.68231466
31MP0001968_abnormal_touch/_nociception1.67810267
32MP0010368_abnormal_lymphatic_system1.64177893
33MP0004215_abnormal_myocardial_fiber1.61509608
34MP0002928_abnormal_bile_duct1.59548178
35MP0010386_abnormal_urinary_bladder1.57061331
36MP0000049_abnormal_middle_ear1.56919452
37MP0001502_abnormal_circadian_rhythm1.56716174
38MP0000631_abnormal_neuroendocrine_gland1.52931882
39MP0002557_abnormal_social/conspecific_i1.52154095
40MP0002184_abnormal_innervation1.48376303
41MP0001501_abnormal_sleep_pattern1.47654701
42MP0003938_abnormal_ear_development1.45401877
43MP0004133_heterotaxia1.43925313
44MP0003787_abnormal_imprinting1.43372032
45MP0001440_abnormal_grooming_behavior1.42652989
46MP0001879_abnormal_lymphatic_vessel1.41622403
47MP0004885_abnormal_endolymph1.41142575
48MP0009379_abnormal_foot_pigmentation1.35095616
49MP0002876_abnormal_thyroid_physiology1.31433987
50MP0002638_abnormal_pupillary_reflex1.31306470
51MP0005187_abnormal_penis_morphology1.30752927
52MP0002734_abnormal_mechanical_nocicepti1.30707147
53MP0002160_abnormal_reproductive_system1.30603003
54MP0005423_abnormal_somatic_nervous1.29129668
55MP0008877_abnormal_DNA_methylation1.26227237
56MP0002909_abnormal_adrenal_gland1.25120243
57MP0002938_white_spotting1.24902935
58MP0003183_abnormal_peptide_metabolism1.24260993
59MP0009780_abnormal_chondrocyte_physiolo1.23911347
60MP0004924_abnormal_behavior1.23660754
61MP0005386_behavior/neurological_phenoty1.23660754
62MP0002736_abnormal_nociception_after1.23273513
63MP0000566_synostosis1.22902440
64MP0004043_abnormal_pH_regulation1.22885308
65MP0003011_delayed_dark_adaptation1.21861620
66MP0000427_abnormal_hair_cycle1.19717185
67MP0000383_abnormal_hair_follicle1.17894413
68MP0009046_muscle_twitch1.17889154
69MP0004085_abnormal_heartbeat1.17281732
70MP0001984_abnormal_olfaction1.16922288
71MP0000749_muscle_degeneration1.16801213
72MP0005670_abnormal_white_adipose1.15962034
73MP0002234_abnormal_pharynx_morphology1.15663680
74MP0002108_abnormal_muscle_morphology1.14908211
75MP0003137_abnormal_impulse_conducting1.13598696
76MP0001177_atelectasis1.12744858
77MP0001986_abnormal_taste_sensitivity1.11988082
78MP0000026_abnormal_inner_ear1.11416105
79MP0008872_abnormal_physiological_respon1.11273056
80MP0002102_abnormal_ear_morphology1.09236013
81MP0001963_abnormal_hearing_physiology1.08350888
82MP0002177_abnormal_outer_ear1.06961373
83MP0002882_abnormal_neuron_morphology1.06693138
84MP0009384_cardiac_valve_regurgitation1.05017616
85MP0008569_lethality_at_weaning1.04241063
86MP0001485_abnormal_pinna_reflex1.03320431
87MP0002249_abnormal_larynx_morphology1.02707602
88MP0005551_abnormal_eye_electrophysiolog1.02251997
89MP0000955_abnormal_spinal_cord1.01514766
90MP0003045_fibrosis1.00168531
91MP0000230_abnormal_systemic_arterial0.97994888
92MP0002653_abnormal_ependyma_morphology0.97601047
93MP0005174_abnormal_tail_pigmentation0.97118956
94MP0006072_abnormal_retinal_apoptosis0.96596421
95MP0004134_abnormal_chest_morphology0.96318051
96MP0004130_abnormal_muscle_cell0.96010564
97MP0009250_abnormal_appendicular_skeleto0.94254731
98MP0005195_abnormal_posterior_eye0.93549156
99MP0002009_preneoplasia0.93423466
100MP0005389_reproductive_system_phenotype0.93330237
101MP0004484_altered_response_of0.92143107
102MP0003122_maternal_imprinting0.90528148
103MP0002822_catalepsy0.89855690
104MP0004142_abnormal_muscle_tone0.89289042
105MP0003890_abnormal_embryonic-extraembry0.88818454
106MP0004272_abnormal_basement_membrane0.87077184
107MP0005595_abnormal_vascular_smooth0.86548852
108MP0001970_abnormal_pain_threshold0.86397910
109MP0002066_abnormal_motor_capabilities/c0.85830018
110MP0003633_abnormal_nervous_system0.85089981
111MP0002752_abnormal_somatic_nervous0.84261802
112MP0000538_abnormal_urinary_bladder0.83279042
113MP0005253_abnormal_eye_physiology0.81854861
114MP0003879_abnormal_hair_cell0.81619354
115MP0000678_abnormal_parathyroid_gland0.81579844
116MP0002733_abnormal_thermal_nociception0.81373751
117MP0003119_abnormal_digestive_system0.81193106
118MP0001905_abnormal_dopamine_level0.80708783
119MP0003631_nervous_system_phenotype0.80490933
120MP0003121_genomic_imprinting0.80425972
121* MP0002152_abnormal_brain_morphology0.79594559
122MP0005620_abnormal_muscle_contractility0.79262708
123MP0000534_abnormal_ureter_morphology0.79094341
124MP0003937_abnormal_limbs/digits/tail_de0.78883259
125MP0008775_abnormal_heart_ventricle0.78466231
126MP0004742_abnormal_vestibular_system0.78104054
127MP0003828_pulmonary_edema0.77724650
128MP0005379_endocrine/exocrine_gland_phen0.73263701
129MP0002972_abnormal_cardiac_muscle0.71727308
130MP0003935_abnormal_craniofacial_develop0.70763349
131MP0004147_increased_porphyrin_level0.70231220

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.32194405
2Focal motor seizures (HP:0011153)4.38025833
3Oligodactyly (hands) (HP:0001180)3.96260826
4Pancreatic cysts (HP:0001737)3.80495624
5Congenital malformation of the right heart (HP:0011723)3.64997682
6Double outlet right ventricle (HP:0001719)3.64997682
7Aqueductal stenosis (HP:0002410)3.51904951
8Hemiparesis (HP:0001269)3.27262631
9Intestinal atresia (HP:0011100)3.21626090
10Drooling (HP:0002307)3.16830469
11Excessive salivation (HP:0003781)3.16830469
12Absent speech (HP:0001344)3.11968284
13Abnormality of the parathyroid morphology (HP:0011766)3.06301034
14Blue irides (HP:0000635)3.04634296
15Chin dimple (HP:0010751)3.02862557
16Broad-based gait (HP:0002136)3.02121906
17Mixed hearing impairment (HP:0000410)3.01317838
18Fair hair (HP:0002286)3.00951463
19Progressive cerebellar ataxia (HP:0002073)2.97015685
20Febrile seizures (HP:0002373)2.95637503
21Abnormal ciliary motility (HP:0012262)2.88920892
22Decreased circulating renin level (HP:0003351)2.87542506
23Congenital stationary night blindness (HP:0007642)2.83764586
24Cupped ear (HP:0000378)2.79080745
25Abnormality of the renal cortex (HP:0011035)2.76054862
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.72779591
27Cystic liver disease (HP:0006706)2.67698598
28Thickened helices (HP:0000391)2.66515346
29Abnormal respiratory motile cilium physiology (HP:0012261)2.62881588
30Nonprogressive disorder (HP:0003680)2.58543240
31Medial flaring of the eyebrow (HP:0010747)2.58413823
32Oligodactyly (HP:0012165)2.58387024
33Congenital sensorineural hearing impairment (HP:0008527)2.58096654
34Scanning speech (HP:0002168)2.57898663
35Widely spaced teeth (HP:0000687)2.52307700
36Large for gestational age (HP:0001520)2.50278105
37Keratoconus (HP:0000563)2.50098772
38Increased corneal curvature (HP:0100692)2.50098772
39Type II lissencephaly (HP:0007260)2.49475766
40Protruding tongue (HP:0010808)2.47506696
41Epileptic encephalopathy (HP:0200134)2.47260472
42Tubular atrophy (HP:0000092)2.47080538
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43022821
44Hemiplegia (HP:0002301)2.40726025
45Furrowed tongue (HP:0000221)2.40401014
46Broad metatarsal (HP:0001783)2.39616172
47Anophthalmia (HP:0000528)2.38962433
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37524706
49Generalized hypopigmentation of hair (HP:0011358)2.33261205
50Prolonged QT interval (HP:0001657)2.31977842
51Polydipsia (HP:0001959)2.31680994
52Abnormal drinking behavior (HP:0030082)2.31680994
53Gaze-evoked nystagmus (HP:0000640)2.30023237
54Midline defect of the nose (HP:0004122)2.29333764
55Obstructive sleep apnea (HP:0002870)2.27337360
56Down-sloping shoulders (HP:0200021)2.25820954
57Thyroid-stimulating hormone excess (HP:0002925)2.23336673
58Chorioretinal atrophy (HP:0000533)2.22408117
59Laryngomalacia (HP:0001601)2.20517986
60Chronic hepatic failure (HP:0100626)2.19982241
61Atrial fibrillation (HP:0005110)2.19864728
62Focal seizures (HP:0007359)2.19396510
63Congenital, generalized hypertrichosis (HP:0004540)2.19052890
64Gait imbalance (HP:0002141)2.16753611
65Genetic anticipation (HP:0003743)2.16364232
66Hypothermia (HP:0002045)2.15720233
67Genital tract atresia (HP:0001827)2.13691562
68Abnormality of salivation (HP:0100755)2.13621664
69Hyperkalemia (HP:0002153)2.13491162
70Exotropia (HP:0000577)2.10945791
71Calf muscle hypertrophy (HP:0008981)2.10536347
72Clumsiness (HP:0002312)2.10038433
73Abnormality of the antihelix (HP:0009738)2.09487666
74Male pseudohermaphroditism (HP:0000037)2.08691024
75Increased circulating renin level (HP:0000848)2.08333081
76Primary atrial arrhythmia (HP:0001692)2.07637553
77Abolished electroretinogram (ERG) (HP:0000550)2.06092451
78Nephronophthisis (HP:0000090)2.05881025
79Aplasia involving bones of the upper limbs (HP:0009823)2.05832253
80Aplasia of the phalanges of the hand (HP:0009802)2.05832253
81Aplasia involving bones of the extremities (HP:0009825)2.05832253
82Bradycardia (HP:0001662)2.03790412
83Retinal dysplasia (HP:0007973)2.03603325
84Inability to walk (HP:0002540)2.03445275
85True hermaphroditism (HP:0010459)2.03211640
86Absent/shortened dynein arms (HP:0200106)2.03197888
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.03197888
88Hamartoma of the eye (HP:0010568)2.02602947
89Vaginal atresia (HP:0000148)2.02110797
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.00864902
91Agitation (HP:0000713)2.00679826
92Short tibia (HP:0005736)1.99632732
93Short 4th metacarpal (HP:0010044)1.99562486
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99562486
95Alacrima (HP:0000522)1.98843030
96Muscle hypertrophy of the lower extremities (HP:0008968)1.98720232
97Atonic seizures (HP:0010819)1.98403023
98Bifid scrotum (HP:0000048)1.98002064
99Anosmia (HP:0000458)1.94703614
100Congenital primary aphakia (HP:0007707)1.94386776
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.92774664
102Humeroradial synostosis (HP:0003041)1.92578201
103Synostosis involving the elbow (HP:0003938)1.92578201
104Morphological abnormality of the middle ear (HP:0008609)1.92418540
105Abnormal respiratory epithelium morphology (HP:0012253)1.92089100
106Abnormal respiratory motile cilium morphology (HP:0005938)1.92089100
107Supraventricular tachycardia (HP:0004755)1.91788484
108Hypoplastic ischia (HP:0003175)1.91512574
109Sclerocornea (HP:0000647)1.91123064
110Dialeptic seizures (HP:0011146)1.90711194
111Optic nerve hypoplasia (HP:0000609)1.89628955
112Esophageal atresia (HP:0002032)1.89270875
113Open mouth (HP:0000194)1.88732057
114Labial hypoplasia (HP:0000066)1.88399829
115Supraventricular arrhythmia (HP:0005115)1.88044378
116Abnormality of the renal medulla (HP:0100957)1.87220030
117Abnormality of the calf musculature (HP:0001430)1.86699471
118Decreased lacrimation (HP:0000633)1.85625776
119Infantile muscular hypotonia (HP:0008947)1.84929537
120Sudden death (HP:0001699)1.84682401
121Abnormality of the nasal septum (HP:0000419)1.84475230
122Metabolic alkalosis (HP:0200114)1.84153070
123Methylmalonic acidemia (HP:0002912)1.83664764
124Tented upper lip vermilion (HP:0010804)1.83340822
125Long nose (HP:0003189)1.82143827
126Pendular nystagmus (HP:0012043)1.81452125
127Hyperactive renin-angiotensin system (HP:0000841)1.81125186
128Attenuation of retinal blood vessels (HP:0007843)1.81086996
129Congenital hepatic fibrosis (HP:0002612)1.80839263
130Nephrogenic diabetes insipidus (HP:0009806)1.80245045
131Toxemia of pregnancy (HP:0100603)1.79908609
132Syncope (HP:0001279)1.79847272
133Truncal ataxia (HP:0002078)1.79622025
134Goiter (HP:0000853)1.79576759
135Prominent supraorbital ridges (HP:0000336)1.79361801
136Short hallux (HP:0010109)1.78607854
137Fibular hypoplasia (HP:0003038)1.78172081
138Megalencephaly (HP:0001355)1.78151259
139Tubulointerstitial nephritis (HP:0001970)1.78061289
140Omphalocele (HP:0001539)1.78010396
141Steppage gait (HP:0003376)1.77381732
142Epileptiform EEG discharges (HP:0011182)1.75147848
143Molar tooth sign on MRI (HP:0002419)1.74965305
144Abnormality of midbrain morphology (HP:0002418)1.74965305
145Abnormality of the ischium (HP:0003174)1.74429221
146Action tremor (HP:0002345)1.74334499
147Polyuria (HP:0000103)1.73438553
148Bell-shaped thorax (HP:0001591)1.72975917
149Confusion (HP:0001289)1.72103187
150Abnormality of binocular vision (HP:0011514)1.72096864
151Diplopia (HP:0000651)1.72096864
152Pancreatic fibrosis (HP:0100732)1.71554799
153Tubulointerstitial fibrosis (HP:0005576)1.70230406
154Ventricular fibrillation (HP:0001663)1.69544728
155Decreased central vision (HP:0007663)1.69533254
156Progressive inability to walk (HP:0002505)1.69235886
157Short foot (HP:0001773)1.69188127
158Postaxial hand polydactyly (HP:0001162)1.68907505
159Impaired smooth pursuit (HP:0007772)1.68767988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.09739861
2NTRK34.61216598
3TNIK4.48177058
4EPHA43.85041531
5CASK3.51395694
6MUSK3.31375145
7INSRR3.13165931
8ACVR1B2.09607133
9MKNK21.81793542
10MAPK151.81355372
11MAP2K71.78343156
12SGK21.73410059
13MARK11.72339789
14MAPK131.71356659
15NTRK21.63516928
16MAP4K21.53472031
17CAMK1G1.52962889
18SGK4941.46361596
19SGK2231.46361596
20TAOK31.38682506
21CDK31.37875872
22SRPK11.36887904
23CAMK2B1.35922560
24PHKG21.32637223
25PHKG11.32637223
26FES1.29339360
27NUAK11.28951609
28MAP3K41.23626748
29WNK41.22629153
30PIK3CA1.21762604
31MARK21.21364044
32SGK31.20741838
33YES11.17333150
34DMPK1.15797681
35PNCK1.13954924
36CAMK1D1.13827839
37OXSR11.13068347
38CAMK11.12825747
39FER1.11402890
40ZAK1.08735770
41CAMK2A1.08651689
42LATS11.08564369
43PRPF4B1.08238545
44DAPK21.07748019
45AKT31.07220486
46ADRBK11.02394145
47PKN11.00801419
48NLK0.98205449
49PRKAA20.95282287
50WNK30.92485194
51SGK10.91682298
52CAMK2D0.91411417
53OBSCN0.91311246
54PRKCE0.87563055
55IRAK10.86364453
56DYRK1A0.85236654
57BRD40.84948807
58PAK30.84693106
59BMPR1B0.84595684
60DDR20.84155795
61HIPK20.83211437
62STK38L0.82858906
63TGFBR10.82723988
64TLK10.80915826
65NEK60.79685604
66CAMKK20.78414392
67DYRK20.74468889
68TIE10.74119833
69PINK10.73441429
70CAMK40.72997408
71GRK10.69947078
72MAP3K70.69890652
73PRKD20.69267196
74CDK50.69238101
75FGFR20.68777706
76IRAK20.68716625
77PRKCG0.68615918
78GRK70.68117086
79TRPM70.67187877
80UHMK10.65577079
81SIK20.64482267
82PRKG10.62089655
83ERBB20.61915696
84MAP2K40.60426928
85RIPK40.58302685
86FGR0.57136645
87MAP3K60.56858692
88WNK10.55400023
89ADRBK20.55153610
90CAMK2G0.54005062
91CSNK1A1L0.53635538
92PTK2B0.50892014
93PRKACA0.50835086
94ERBB30.49788225
95MYLK0.49023147
96IGF1R0.48805652
97EPHA30.48801910
98ROCK10.48106758
99PRKCZ0.45415029
100SIK10.44949562
101CSNK1G10.44928204
102LMTK20.44621930
103CSNK1G20.44259292
104CDC42BPA0.43561788
105MAP2K10.43235346
106MAP3K20.42427941
107PDGFRB0.42170441
108FGFR30.41475398
109RPS6KA30.41392906
110PDGFRA0.41321759
111PRKCQ0.41224090
112PLK20.40062302
113BMPR20.38321089
114CSNK1G30.38227863
115MAPK100.38121942
116MAPKAPK50.37977577
117PRKCH0.37946499
118MELK0.36723129
119STK390.35549889
120PRKAA10.35144316
121PRKCA0.35048281
122EPHB20.34831499
123NEK90.34563106
124CHUK0.34344637
125PRKACB0.34201146
126MKNK10.34185496
127STK110.33351281
128CSNK1A10.32956688

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59553145
2Circadian entrainment_Homo sapiens_hsa047132.69844529
3Glutamatergic synapse_Homo sapiens_hsa047242.67342669
4Taste transduction_Homo sapiens_hsa047422.53543385
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41301647
6Morphine addiction_Homo sapiens_hsa050322.27334855
7Amphetamine addiction_Homo sapiens_hsa050312.26208450
8GABAergic synapse_Homo sapiens_hsa047272.18190295
9Insulin secretion_Homo sapiens_hsa049112.03209965
10Long-term potentiation_Homo sapiens_hsa047201.99615525
11Linoleic acid metabolism_Homo sapiens_hsa005911.93668036
12Salivary secretion_Homo sapiens_hsa049701.81969911
13Calcium signaling pathway_Homo sapiens_hsa040201.79572424
14Serotonergic synapse_Homo sapiens_hsa047261.77818327
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75633678
16Renin secretion_Homo sapiens_hsa049241.75154722
17Cocaine addiction_Homo sapiens_hsa050301.74083161
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72717570
19cAMP signaling pathway_Homo sapiens_hsa040241.72040043
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68527476
21Dopaminergic synapse_Homo sapiens_hsa047281.66110613
22Circadian rhythm_Homo sapiens_hsa047101.58249191
23Long-term depression_Homo sapiens_hsa047301.53058819
24Dilated cardiomyopathy_Homo sapiens_hsa054141.52195051
25Axon guidance_Homo sapiens_hsa043601.51670833
26Olfactory transduction_Homo sapiens_hsa047401.51596420
27Cholinergic synapse_Homo sapiens_hsa047251.50890166
28Gastric acid secretion_Homo sapiens_hsa049711.41396697
29Ether lipid metabolism_Homo sapiens_hsa005651.39535082
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32519738
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31411074
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31154282
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29296867
34Oxytocin signaling pathway_Homo sapiens_hsa049211.27708568
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24464264
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23715285
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.21168555
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20048125
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17525019
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17295007
41GnRH signaling pathway_Homo sapiens_hsa049121.13166014
42Histidine metabolism_Homo sapiens_hsa003401.12018320
43Chemical carcinogenesis_Homo sapiens_hsa052041.09420942
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08409026
45Ovarian steroidogenesis_Homo sapiens_hsa049131.08043948
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06906947
47Melanogenesis_Homo sapiens_hsa049161.00132222
48Type II diabetes mellitus_Homo sapiens_hsa049300.98546667
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97449447
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96953419
51Retinol metabolism_Homo sapiens_hsa008300.94387155
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.92017799
53Lysine degradation_Homo sapiens_hsa003100.90120986
54Gap junction_Homo sapiens_hsa045400.89970187
55Pancreatic secretion_Homo sapiens_hsa049720.89904009
56Choline metabolism in cancer_Homo sapiens_hsa052310.88473468
57Phototransduction_Homo sapiens_hsa047440.88035540
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87674160
59Selenocompound metabolism_Homo sapiens_hsa004500.86968504
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86573582
61Wnt signaling pathway_Homo sapiens_hsa043100.86351953
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82697025
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80085958
64Cardiac muscle contraction_Homo sapiens_hsa042600.78083556
65Dorso-ventral axis formation_Homo sapiens_hsa043200.77416567
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76965761
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76270226
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75634844
69ErbB signaling pathway_Homo sapiens_hsa040120.75545505
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.75407301
71Thyroid hormone synthesis_Homo sapiens_hsa049180.75119764
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74742306
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74102464
74beta-Alanine metabolism_Homo sapiens_hsa004100.73817015
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.70425082
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70055852
77ABC transporters_Homo sapiens_hsa020100.69254007
78Estrogen signaling pathway_Homo sapiens_hsa049150.68411243
79Ras signaling pathway_Homo sapiens_hsa040140.68241723
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67612430
81TGF-beta signaling pathway_Homo sapiens_hsa043500.67226295
82Caffeine metabolism_Homo sapiens_hsa002320.67056973
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66722888
84ECM-receptor interaction_Homo sapiens_hsa045120.66337658
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66293362
86Glucagon signaling pathway_Homo sapiens_hsa049220.65263014
87Nitrogen metabolism_Homo sapiens_hsa009100.64978886
88African trypanosomiasis_Homo sapiens_hsa051430.64959780
89Peroxisome_Homo sapiens_hsa041460.63907377
90Arachidonic acid metabolism_Homo sapiens_hsa005900.62960074
91Propanoate metabolism_Homo sapiens_hsa006400.61566940
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61305911
93Rap1 signaling pathway_Homo sapiens_hsa040150.60750598
94MAPK signaling pathway_Homo sapiens_hsa040100.60225595
95Sphingolipid metabolism_Homo sapiens_hsa006000.56859329
96Bile secretion_Homo sapiens_hsa049760.54519190
97Mineral absorption_Homo sapiens_hsa049780.52921021
98Glioma_Homo sapiens_hsa052140.52072339
99Regulation of autophagy_Homo sapiens_hsa041400.51566441
100Hippo signaling pathway_Homo sapiens_hsa043900.50141615
101Hedgehog signaling pathway_Homo sapiens_hsa043400.47171845
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46300950
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45887534
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45554300
105PPAR signaling pathway_Homo sapiens_hsa033200.44946929
106Butanoate metabolism_Homo sapiens_hsa006500.44246751
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42335909
108Protein digestion and absorption_Homo sapiens_hsa049740.42241520
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42184447
110Basal cell carcinoma_Homo sapiens_hsa052170.41897591
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41186112
112Inositol phosphate metabolism_Homo sapiens_hsa005620.40848272
113Focal adhesion_Homo sapiens_hsa045100.40835064
114FoxO signaling pathway_Homo sapiens_hsa040680.39956797
115Glycerolipid metabolism_Homo sapiens_hsa005610.39396829
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38694380
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38571051
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38432420
119Fatty acid biosynthesis_Homo sapiens_hsa000610.38280927
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38223802
121Fatty acid metabolism_Homo sapiens_hsa012120.37560917
122Vitamin digestion and absorption_Homo sapiens_hsa049770.36462832
123Adherens junction_Homo sapiens_hsa045200.35898613
124Tryptophan metabolism_Homo sapiens_hsa003800.35392492
125Melanoma_Homo sapiens_hsa052180.34692146
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.34263816
127Fatty acid elongation_Homo sapiens_hsa000620.33846020

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