ZBTB21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.25976634
2nuclear pore organization (GO:0006999)5.95869329
3mitotic sister chromatid cohesion (GO:0007064)5.70363879
4monoubiquitinated protein deubiquitination (GO:0035520)4.68728819
5dosage compensation (GO:0007549)4.56359194
6pore complex assembly (GO:0046931)4.50969307
7peptidyl-lysine trimethylation (GO:0018023)4.14837246
8regulation of RNA export from nucleus (GO:0046831)4.12462950
9cytoplasmic mRNA processing body assembly (GO:0033962)4.11846241
10ER overload response (GO:0006983)4.05319243
11regulation of DNA endoreduplication (GO:0032875)3.79035563
12COPII vesicle coating (GO:0048208)3.71578649
13histone H3-K4 methylation (GO:0051568)3.70300591
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.67442870
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.67442870
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.67442870
17negative regulation of histone methylation (GO:0031061)3.60459921
18regulation of nucleobase-containing compound transport (GO:0032239)3.49989907
19histone demethylation (GO:0016577)3.49366281
20regulation of NFAT protein import into nucleus (GO:0051532)3.45344255
21sister chromatid cohesion (GO:0007062)3.44349956
22regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.43799212
23negative regulation of neurotransmitter secretion (GO:0046929)3.38300397
24peptidyl-lysine methylation (GO:0018022)3.35335953
25histone lysine demethylation (GO:0070076)3.32292671
26regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.31700536
27positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.31700536
28interkinetic nuclear migration (GO:0022027)3.28808737
29regulation of RIG-I signaling pathway (GO:0039535)3.28600110
30response to muramyl dipeptide (GO:0032495)3.27173522
31regulation of histone H3-K27 methylation (GO:0061085)3.24113648
32N-terminal protein amino acid acetylation (GO:0006474)3.22060513
33positive regulation of DNA-templated transcription, initiation (GO:2000144)3.18152082
34snRNA transcription (GO:0009301)3.16222126
35negative regulation of mast cell activation (GO:0033004)3.13771469
36fibroblast migration (GO:0010761)3.12475629
37protein dealkylation (GO:0008214)3.09366171
38protein demethylation (GO:0006482)3.09366171
39regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.08621028
40positive regulation of macroautophagy (GO:0016239)3.05545320
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04293704
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.03312899
43histone H3-K9 demethylation (GO:0033169)3.02932554
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.99389101
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.99389101
46histone lysine methylation (GO:0034968)2.97487535
47regulation of histone H3-K4 methylation (GO:0051569)2.95727937
48positive regulation of mRNA catabolic process (GO:0061014)2.94645166
49positive regulation of histone H3-K4 methylation (GO:0051571)2.93178429
50regulation of Rac protein signal transduction (GO:0035020)2.92826656
51replication fork processing (GO:0031297)2.92500329
52positive regulation of mRNA 3-end processing (GO:0031442)2.91082747
53protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.86804174
54mitotic chromosome condensation (GO:0007076)2.84133482
55positive regulation of cellular amide metabolic process (GO:0034250)2.82093638
56poly(A)+ mRNA export from nucleus (GO:0016973)2.80853050
57cellular response to gonadotropin stimulus (GO:0071371)2.80503605
58regulation of chromatin binding (GO:0035561)2.78545612
59branching involved in prostate gland morphogenesis (GO:0060442)2.77322179
60regulation of histone methylation (GO:0031060)2.77028593
61NIK/NF-kappaB signaling (GO:0038061)2.76002173
62regulation of DNA damage checkpoint (GO:2000001)2.75685132
63embryonic process involved in female pregnancy (GO:0060136)2.75300631
64peptidyl-threonine dephosphorylation (GO:0035970)2.74767304
65histone H4-K16 acetylation (GO:0043984)2.73950957
66nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.73501303
67regulation of mRNA 3-end processing (GO:0031440)2.72960852
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72958439
69facial nerve structural organization (GO:0021612)2.72565359
70sister chromatid segregation (GO:0000819)2.72435873
71response to peptidoglycan (GO:0032494)2.72188524
72protein K48-linked deubiquitination (GO:0071108)2.70382396
73interferon-gamma production (GO:0032609)2.68227977
74presynaptic membrane assembly (GO:0097105)2.67422543
75neutrophil activation involved in immune response (GO:0002283)2.66020021
76glucocorticoid receptor signaling pathway (GO:0042921)2.64878523
77cellular response to glucose starvation (GO:0042149)2.63793572
78phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63278382
79membrane disassembly (GO:0030397)2.62802998
80nuclear envelope disassembly (GO:0051081)2.62802998
81nucleus organization (GO:0006997)2.62468788
82histone deubiquitination (GO:0016578)2.60705380
83regulation of mRNA catabolic process (GO:0061013)2.58391623
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56713887
85negative regulation of histone modification (GO:0031057)2.55650222
86early endosome to late endosome transport (GO:0045022)2.55615542
87Golgi to endosome transport (GO:0006895)2.55357263
88protein targeting to Golgi (GO:0000042)2.55028787
89establishment of protein localization to Golgi (GO:0072600)2.54970913
90pre-miRNA processing (GO:0031054)2.54522194
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53213617
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.53213617
93regulation of translation, ncRNA-mediated (GO:0045974)2.53213617
94regulation of histone H3-K9 methylation (GO:0051570)2.53176999
95protein deubiquitination (GO:0016579)2.53084247
96replicative senescence (GO:0090399)2.52689088
97mitotic nuclear envelope disassembly (GO:0007077)2.52460157
98positive regulation of mRNA processing (GO:0050685)2.52092576
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51000396
100microtubule anchoring (GO:0034453)2.49950271
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.47345930
102modulation by symbiont of host immune response (GO:0052553)2.47345930
103positive regulation by symbiont of host defense response (GO:0052509)2.47345930
104modulation by symbiont of host defense response (GO:0052031)2.47345930
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47345930
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47345930
107dendritic cell chemotaxis (GO:0002407)2.46978097
108regulation of cell proliferation involved in kidney development (GO:1901722)2.45143238
109ribosome assembly (GO:0042255)2.44922034
110histone H2B ubiquitination (GO:0033523)2.44718192
111signal peptide processing (GO:0006465)2.44471565
112positive regulation of gamma-delta T cell activation (GO:0046645)2.44460477
113positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.44127313
114negative regulation of dendrite morphogenesis (GO:0050774)2.44068416
115stress granule assembly (GO:0034063)2.43261389
116regulation of transforming growth factor beta1 production (GO:0032908)2.43131482
117positive regulation of mRNA metabolic process (GO:1903313)2.42961856
118protein localization to microtubule (GO:0035372)2.42348625
119neutrophil activation (GO:0042119)2.41847888
120positive regulation of chromosome segregation (GO:0051984)2.39157942
121hepatocyte apoptotic process (GO:0097284)2.38795551
122coronary vasculature morphogenesis (GO:0060977)2.38780839
123intestinal epithelial cell development (GO:0060576)2.38193684
124positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.37635310
125histone H3-K4 trimethylation (GO:0080182)2.36804462
126regulation of interleukin-12 biosynthetic process (GO:0045075)2.36759706
127regulation of fibroblast apoptotic process (GO:2000269)2.36718768
128polyketide metabolic process (GO:0030638)2.35691369
129doxorubicin metabolic process (GO:0044598)2.35691369
130daunorubicin metabolic process (GO:0044597)2.35691369
131myoblast migration (GO:0051451)2.34573283
132definitive hemopoiesis (GO:0060216)2.34148525
133histone H3-K36 demethylation (GO:0070544)2.33831182
134nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.32976888
135germinal center formation (GO:0002467)2.32191126
136generation of neurons (GO:0048699)2.30360560
137energy homeostasis (GO:0097009)2.30000332
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.29942940
139maturation of 5.8S rRNA (GO:0000460)2.29898324
140positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29825420
141presynaptic membrane organization (GO:0097090)2.29117888
142cell differentiation involved in metanephros development (GO:0072202)2.27282159
143immunoglobulin mediated immune response (GO:0016064)2.25648178
144dendritic cell migration (GO:0036336)2.25015755
145cellular response to gamma radiation (GO:0071480)2.24677334
146negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.24547970
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.24066736
148protein K6-linked ubiquitination (GO:0085020)2.22733582
149meiotic chromosome segregation (GO:0045132)2.22434492
150protein K11-linked deubiquitination (GO:0035871)2.22212018
151negative regulation of keratinocyte proliferation (GO:0010839)2.20706676
152DNA dealkylation (GO:0035510)2.19411776
153positive regulation of macrophage differentiation (GO:0045651)2.19257318
154interferon-gamma-mediated signaling pathway (GO:0060333)2.18043796
155DNA double-strand break processing (GO:0000729)2.17452258
156glycosphingolipid catabolic process (GO:0046479)2.15378969
157myeloid dendritic cell activation (GO:0001773)2.15223214
158viral protein processing (GO:0019082)2.15150092
159cellular response to ionizing radiation (GO:0071479)2.14861772
160tRNA methylation (GO:0030488)2.14748517
161cellular response to type I interferon (GO:0071357)2.13772702
162type I interferon signaling pathway (GO:0060337)2.13772702
163T cell activation involved in immune response (GO:0002286)2.13748070
164DNA synthesis involved in DNA repair (GO:0000731)2.13306197
165negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.11735737
166inner ear receptor cell differentiation (GO:0060113)2.10614695
167granulocyte activation (GO:0036230)2.10270005
168response to protozoan (GO:0001562)2.10249638
169B cell homeostasis (GO:0001782)2.10025250
170defense response to protozoan (GO:0042832)2.09621141
171positive regulation of interferon-alpha production (GO:0032727)2.09377245
172I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.09363806
173protein sumoylation (GO:0016925)2.08721377
174positive regulation of protein homooligomerization (GO:0032464)2.08067733
175female gonad development (GO:0008585)2.07594606
176cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.07310369
177regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.07089571
178regulation of mitotic spindle checkpoint (GO:1903504)2.07089571
179T-helper cell differentiation (GO:0042093)2.06856888
180CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.06856888
181response to type I interferon (GO:0034340)2.06341528
182positive regulation of DNA recombination (GO:0045911)2.05690258
183negative regulation of viral genome replication (GO:0045071)2.05615831
184regulation of mast cell activation (GO:0033003)2.05589241
185negative regulation of signal transduction by p53 class mediator (GO:1901797)2.05102043
186nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.04973809
187regulation of nuclear cell cycle DNA replication (GO:0033262)2.04877600
188response to interferon-alpha (GO:0035455)2.04641045
189positive regulation of heat generation (GO:0031652)2.04175336
190regulation of chromatin silencing (GO:0031935)2.02682234
191CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.02675330
192kinetochore assembly (GO:0051382)2.02122562
193positive regulation of interleukin-17 production (GO:0032740)2.01720030
194regulation of interferon-alpha production (GO:0032647)2.01384549
195centriole assembly (GO:0098534)2.01133258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.45942947
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.28203286
3E2F7_22180533_ChIP-Seq_HELA_Human4.27680911
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.24286587
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.12099279
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.03458801
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.87120665
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.79943556
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79525659
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72492581
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57376798
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52708109
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.48402390
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.46799776
15GBX2_23144817_ChIP-Seq_PC3_Human2.27201115
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25803819
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.24489438
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.23971749
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23781118
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.06248575
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.02506340
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02030316
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91946414
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89075534
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86261768
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84192834
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.78680784
28FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.76414396
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76390278
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74107063
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73567677
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.73001746
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70778680
34FUS_26573619_Chip-Seq_HEK293_Human1.69722635
35CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68439656
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67775877
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67343042
38SCL_19346495_ChIP-Seq_HPC-7_Human1.66365114
39ELK1_19687146_ChIP-ChIP_HELA_Human1.64808084
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62035112
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60497779
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60356624
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57011498
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.56853479
45RUNX_20019798_ChIP-Seq_JUKART_Human1.56543454
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.53614839
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52631632
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49970219
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49065798
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47197432
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44588352
52EWS_26573619_Chip-Seq_HEK293_Human1.44527756
53TFEB_21752829_ChIP-Seq_HELA_Human1.44310943
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43375336
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.43051078
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42217099
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41381032
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40454414
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.39943976
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39533200
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39325955
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38114221
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37917006
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37602325
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.36768292
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36711951
67BRD4_25478319_ChIP-Seq_HGPS_Human1.35547429
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.35233659
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35032146
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34597844
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34455205
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33045745
73CHD1_26751641_Chip-Seq_LNCaP_Human1.32915077
74FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.32310648
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.28967838
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27858451
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.26769744
78CIITA_25753668_ChIP-Seq_RAJI_Human1.26552200
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26463407
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25608083
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.25327498
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24826314
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23467637
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23320171
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21836651
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21289473
87P53_22387025_ChIP-Seq_ESCs_Mouse1.20030863
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19099759
89P300_19829295_ChIP-Seq_ESCs_Human1.18409820
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17367585
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17331529
92RNF2_27304074_Chip-Seq_NSC_Mouse1.16742697
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.16322832
94MYB_26560356_Chip-Seq_TH2_Human1.16153817
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15413504
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15267933
97AR_21909140_ChIP-Seq_LNCAP_Human1.13303301
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12596622
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12596622
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12572811
101VDR_23849224_ChIP-Seq_CD4+_Human1.11580276
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11250345
103P300_18555785_Chip-Seq_ESCs_Mouse1.08095864
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07844230
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07827789
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07134906
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.06893009
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06067378
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05788792
110IGF1R_20145208_ChIP-Seq_DFB_Human1.05649851
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.05449767
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05437760
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05282848
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04679293
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03615254
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03411238
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03264791
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.03256965
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.02854920
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02802211
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02768466
122PU1_27457419_Chip-Seq_LIVER_Mouse1.02350913
123MYB_26560356_Chip-Seq_TH1_Human1.02145398
124PU_27001747_Chip-Seq_BMDM_Mouse1.01823421
125SPI1_23547873_ChIP-Seq_NB4_Human1.01723500
126STAT3_23295773_ChIP-Seq_U87_Human1.01566806
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00711838
128ZFX_18555785_Chip-Seq_ESCs_Mouse1.00361737
129CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00203357
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00154320
131KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99601362
132TAF15_26573619_Chip-Seq_HEK293_Human0.99122980
133TP53_16413492_ChIP-PET_HCT116_Human0.99115110
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99091117
135ER_23166858_ChIP-Seq_MCF-7_Human0.98832354
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98670852
137AHR_22903824_ChIP-Seq_MCF-7_Human0.98589304
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98313164
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97971327
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97971327
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96452914
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96061406
143KDM5A_27292631_Chip-Seq_BREAST_Human0.96054932
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94905198
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94615061
146MYC_22102868_ChIP-Seq_BL_Human0.94605524
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94380160
148SMAD4_21799915_ChIP-Seq_A2780_Human0.94132159
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.93784206
150GATA1_22025678_ChIP-Seq_K562_Human0.92990399
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92368626
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90999431
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.88950773
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.86291723
155CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84969554
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84116397
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83829003
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83555433
159CBP_20019798_ChIP-Seq_JUKART_Human0.80506692
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80506692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.59795512
2MP0008961_abnormal_basal_metabolism3.35847316
3MP0006292_abnormal_olfactory_placode2.93683063
4MP0000015_abnormal_ear_pigmentation2.73276563
5MP0010234_abnormal_vibrissa_follicle2.62012795
6MP0008007_abnormal_cellular_replicative2.52106821
7MP0001188_hyperpigmentation2.49805949
8MP0001835_abnormal_antigen_presentation2.43057187
9MP0003656_abnormal_erythrocyte_physiolo2.20800720
10MP0005076_abnormal_cell_differentiation2.17141641
11MP0002009_preneoplasia2.13549036
12MP0008058_abnormal_DNA_repair2.09099246
13MP0003763_abnormal_thymus_physiology2.07685356
14MP0003724_increased_susceptibility_to2.05693078
15MP0008057_abnormal_DNA_replication2.02900693
16MP0005171_absent_coat_pigmentation2.01662510
17MP0005174_abnormal_tail_pigmentation1.98090635
18MP0003787_abnormal_imprinting1.93259206
19MP0005075_abnormal_melanosome_morpholog1.92576730
20MP0005671_abnormal_response_to1.90734044
21MP0010678_abnormal_skin_adnexa1.88157760
22MP0000569_abnormal_digit_pigmentation1.85819749
23MP0002148_abnormal_hypersensitivity_rea1.84582211
24MP0002277_abnormal_respiratory_mucosa1.83106334
25MP0002396_abnormal_hematopoietic_system1.80025509
26MP0002877_abnormal_melanocyte_morpholog1.73285794
27MP0004782_abnormal_surfactant_physiolog1.71195825
28MP0003890_abnormal_embryonic-extraembry1.68787053
29MP0003941_abnormal_skin_development1.68071524
30MP0009785_altered_susceptibility_to1.66744897
31MP0001800_abnormal_humoral_immune1.64518177
32MP0003136_yellow_coat_color1.64500131
33MP0005387_immune_system_phenotype1.64458292
34MP0001790_abnormal_immune_system1.64458292
35MP0003436_decreased_susceptibility_to1.63403207
36MP0000516_abnormal_urinary_system1.63193698
37MP0005367_renal/urinary_system_phenotyp1.63193698
38MP0005646_abnormal_pituitary_gland1.62658159
39MP0002405_respiratory_system_inflammati1.62268377
40MP0005000_abnormal_immune_tolerance1.62007994
41MP0002452_abnormal_antigen_presenting1.59221079
42MP0000350_abnormal_cell_proliferation1.58420287
43MP0009697_abnormal_copulation1.52435918
44MP0003828_pulmonary_edema1.49555332
45MP0010094_abnormal_chromosome_stability1.47466287
46MP0002419_abnormal_innate_immunity1.46915820
47MP0002723_abnormal_immune_serum1.44932264
48MP0005409_darkened_coat_color1.43507856
49MP0008789_abnormal_olfactory_epithelium1.43262078
50MP0000383_abnormal_hair_follicle1.42919093
51MP0002006_tumorigenesis1.41435942
52MP0003786_premature_aging1.41152412
53MP0002095_abnormal_skin_pigmentation1.40998440
54MP0002420_abnormal_adaptive_immunity1.40469521
55MP0001819_abnormal_immune_cell1.39341263
56MP0009333_abnormal_splenocyte_physiolog1.37706815
57MP0004264_abnormal_extraembryonic_tissu1.37437100
58MP0000372_irregular_coat_pigmentation1.37264670
59MP0003091_abnormal_cell_migration1.35862452
60MP0001919_abnormal_reproductive_system1.35852184
61MP0004381_abnormal_hair_follicle1.35768673
62MP0005310_abnormal_salivary_gland1.32038476
63MP0001986_abnormal_taste_sensitivity1.30471220
64MP0005623_abnormal_meninges_morphology1.28398972
65MP0005394_taste/olfaction_phenotype1.27666155
66MP0005499_abnormal_olfactory_system1.27666155
67MP0002166_altered_tumor_susceptibility1.27211022
68MP0004957_abnormal_blastocyst_morpholog1.26752571
69MP0002933_joint_inflammation1.25782796
70MP0002177_abnormal_outer_ear1.22787065
71MP0000465_gastrointestinal_hemorrhage1.22123931
72MP0004197_abnormal_fetal_growth/weight/1.21676536
73MP0004233_abnormal_muscle_weight1.21044824
74MP0002398_abnormal_bone_marrow1.21020485
75MP0000049_abnormal_middle_ear1.18711270
76MP0009703_decreased_birth_body1.16225759
77MP0003077_abnormal_cell_cycle1.15780415
78MP0001502_abnormal_circadian_rhythm1.14754651
79MP0004808_abnormal_hematopoietic_stem1.14641306
80MP0000371_diluted_coat_color1.14187676
81MP0003221_abnormal_cardiomyocyte_apopto1.14093289
82MP0005025_abnormal_response_to1.12767563
83MP0003943_abnormal_hepatobiliary_system1.12485173
84MP0003693_abnormal_embryo_hatching1.12022990
85MP0001186_pigmentation_phenotype1.11993633
86MP0001119_abnormal_female_reproductive1.11487679
87MP0003950_abnormal_plasma_membrane1.11472138
88MP0005621_abnormal_cell_physiology1.11408044
89MP0009115_abnormal_fat_cell1.11073433
90MP0001672_abnormal_embryogenesis/_devel1.10863554
91MP0005380_embryogenesis_phenotype1.10863554
92MP0000685_abnormal_immune_system1.10519632
93MP0000716_abnormal_immune_system1.10210879
94MP0001730_embryonic_growth_arrest1.09385720
95MP0000566_synostosis1.09233311
96MP0003984_embryonic_growth_retardation1.08050485
97MP0000490_abnormal_crypts_of1.07112084
98MP0002088_abnormal_embryonic_growth/wei1.06365715
99MP0002075_abnormal_coat/hair_pigmentati1.05455521
100MP0000689_abnormal_spleen_morphology1.05417192
101MP0008995_early_reproductive_senescence1.05097362
102MP0000003_abnormal_adipose_tissue1.04064447
103MP0008877_abnormal_DNA_methylation1.02324707
104MP0001697_abnormal_embryo_size1.00929228
105MP0002084_abnormal_developmental_patter0.98776656
106MP0010155_abnormal_intestine_physiology0.98565365
107MP0005390_skeleton_phenotype0.98375679
108MP0005220_abnormal_exocrine_pancreas0.97970972
109MP0000678_abnormal_parathyroid_gland0.97770083
110MP0001727_abnormal_embryo_implantation0.96826095
111MP0005389_reproductive_system_phenotype0.96098342
112MP0001944_abnormal_pancreas_morphology0.95460157
113MP0010307_abnormal_tumor_latency0.94745671
114MP0005408_hypopigmentation0.93085075
115MP0002163_abnormal_gland_morphology0.92511097
116MP0000703_abnormal_thymus_morphology0.92385091
117MP0001533_abnormal_skeleton_physiology0.90801439
118MP0001984_abnormal_olfaction0.90596530
119MP0005384_cellular_phenotype0.90098505
120MP0002086_abnormal_extraembryonic_tissu0.89672107
121MP0005187_abnormal_penis_morphology0.89109243
122MP0009250_abnormal_appendicular_skeleto0.88563078
123MP0001851_eye_inflammation0.88142886
124MP0002722_abnormal_immune_system0.88026296
125MP0004134_abnormal_chest_morphology0.87810245
126MP0003453_abnormal_keratinocyte_physiol0.86708646
127MP0002429_abnormal_blood_cell0.85847146
128MP0002938_white_spotting0.85793643
129MP0000858_altered_metastatic_potential0.84900947
130MP0003448_altered_tumor_morphology0.84474543
131MP0002998_abnormal_bone_remodeling0.84218963
132MP0002210_abnormal_sex_determination0.83971296
133MP0003111_abnormal_nucleus_morphology0.83424303
134MP0002970_abnormal_white_adipose0.82822577
135MP0005379_endocrine/exocrine_gland_phen0.82272818
136MP0005397_hematopoietic_system_phenotyp0.82003248
137MP0001545_abnormal_hematopoietic_system0.82003248
138MP0003755_abnormal_palate_morphology0.81652150
139MP0005647_abnormal_sex_gland0.81116905
140MP0002160_abnormal_reproductive_system0.80723926
141MP0003868_abnormal_feces_composition0.80152527
142MP0001191_abnormal_skin_condition0.79429549
143MP0001216_abnormal_epidermal_layer0.79410904
144MP0001929_abnormal_gametogenesis0.77162955
145MP0002751_abnormal_autonomic_nervous0.77139112
146MP0003121_genomic_imprinting0.76613174
147MP0008932_abnormal_embryonic_tissue0.76522700
148MP0003935_abnormal_craniofacial_develop0.75824538
149MP0001845_abnormal_inflammatory_respons0.75656397
150MP0001853_heart_inflammation0.75382720
151MP0002085_abnormal_embryonic_tissue0.74361929
152MP0001270_distended_abdomen0.72505706
153MP0000313_abnormal_cell_death0.72326820
154MP0005375_adipose_tissue_phenotype0.72140464
155MP0003115_abnormal_respiratory_system0.71738420
156MP0000647_abnormal_sebaceous_gland0.71575413
157MP0000627_abnormal_mammary_gland0.71115380
158MP0003699_abnormal_female_reproductive0.70540871
159MP0002138_abnormal_hepatobiliary_system0.68744929
160MP0001340_abnormal_eyelid_morphology0.68442290
161MP0002928_abnormal_bile_duct0.68262149
162MP0002080_prenatal_lethality0.68027465
163MP0001784_abnormal_fluid_regulation0.67786805
164MP0000432_abnormal_head_morphology0.67635514
165MP0001145_abnormal_male_reproductive0.67397458
166MP0004947_skin_inflammation0.66146757
167MP0000653_abnormal_sex_gland0.65364314
168MP0001348_abnormal_lacrimal_gland0.63770404

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.01352570
2Volvulus (HP:0002580)4.00250663
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29196773
4Retrobulbar optic neuritis (HP:0100654)3.09027888
5Optic neuritis (HP:0100653)3.09027888
6Curly hair (HP:0002212)3.05824345
7Chromsome breakage (HP:0040012)3.04161183
8Truncal obesity (HP:0001956)3.01617286
9Abnormality of the nasal septum (HP:0000419)2.93964937
10True hermaphroditism (HP:0010459)2.92364613
11Abnormality of the frontal sinuses (HP:0002687)2.90910507
12Thyroid carcinoma (HP:0002890)2.84777980
13Lip pit (HP:0100267)2.84237599
14Absent frontal sinuses (HP:0002688)2.84125637
15Abnormality of incisor morphology (HP:0011063)2.83445620
16Hypoplastic labia majora (HP:0000059)2.81761616
17Macroorchidism (HP:0000053)2.70110930
18Type I transferrin isoform profile (HP:0003642)2.69477966
19Abnormality of the prostate (HP:0008775)2.68020128
20Abnormal hair whorl (HP:0010721)2.66852076
21Pancreatic fibrosis (HP:0100732)2.64399144
22Relative macrocephaly (HP:0004482)2.64355391
23Irregular epiphyses (HP:0010582)2.64325704
24Menstrual irregularities (HP:0000858)2.59496012
25Hypothermia (HP:0002045)2.58213860
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56556111
27Syringomyelia (HP:0003396)2.55825723
28Spinal cord lesions (HP:0100561)2.55825723
29Sparse lateral eyebrow (HP:0005338)2.52302498
30Recurrent abscess formation (HP:0002722)2.51601188
31Heterotopia (HP:0002282)2.51274559
32Orchitis (HP:0100796)2.48336706
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48279809
34Septate vagina (HP:0001153)2.46416353
35Flat capital femoral epiphysis (HP:0003370)2.44065214
36Low anterior hairline (HP:0000294)2.42862477
37Abnormality of the labia majora (HP:0012881)2.42115467
38Epiphyseal dysplasia (HP:0002656)2.36169971
39Myositis (HP:0100614)2.35863567
40Narrow palate (HP:0000189)2.34350231
41Testicular neoplasm (HP:0010788)2.32920909
42Acute myeloid leukemia (HP:0004808)2.32617232
43Vitreoretinal degeneration (HP:0000655)2.31834777
44Deep palmar crease (HP:0006191)2.30179862
45Long eyelashes (HP:0000527)2.29886586
46Birth length less than 3rd percentile (HP:0003561)2.29201251
47Aqueductal stenosis (HP:0002410)2.28948145
48Abnormality of chromosome segregation (HP:0002916)2.28682158
49Overlapping toe (HP:0001845)2.28574973
50Stomach cancer (HP:0012126)2.26599009
51Stomatitis (HP:0010280)2.26145586
52Abnormality of the phalanges of the hallux (HP:0010057)2.26014252
53Clubbing of toes (HP:0100760)2.24622823
54Thickened helices (HP:0000391)2.22294436
55Cubitus valgus (HP:0002967)2.19976347
56Abnormality of the epiphyses of the hand (HP:0005924)2.19422406
57Median cleft lip (HP:0000161)2.18036693
58Abnormal pancreas size (HP:0012094)2.17634922
59Cystic hygroma (HP:0000476)2.17627484
60Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.17014595
61Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.16523286
62Abnormality of the fingertips (HP:0001211)2.15416910
63Abnormality of chromosome stability (HP:0003220)2.13823967
64Recurrent bacterial skin infections (HP:0005406)2.13632820
65Widely spaced teeth (HP:0000687)2.11526168
66Ectopic kidney (HP:0000086)2.11516677
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11459832
68Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.10968103
69Mediastinal lymphadenopathy (HP:0100721)2.10709553
70Type 2 muscle fiber atrophy (HP:0003554)2.07776582
71Intestinal atresia (HP:0011100)2.06742374
72Transposition of the great arteries (HP:0001669)2.06296862
73Abnormal connection of the cardiac segments (HP:0011545)2.06296862
74Abnormal ventriculo-arterial connection (HP:0011563)2.06296862
75Hyperventilation (HP:0002883)2.05112985
76Neonatal hypoglycemia (HP:0001998)2.04411902
77Submucous cleft hard palate (HP:0000176)2.02601853
78Chronic hepatic failure (HP:0100626)2.02504068
79Germ cell neoplasia (HP:0100728)2.01067256
80Reduced antithrombin III activity (HP:0001976)1.99164558
81Abnormality of the ileum (HP:0001549)1.98103978
82Patchy hypopigmentation of hair (HP:0011365)1.97285794
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.96669107
84Transitional cell carcinoma of the bladder (HP:0006740)1.96286611
85Sandal gap (HP:0001852)1.95867510
86Abnormality of the incisor (HP:0000676)1.95765408
87Bladder carcinoma (HP:0002862)1.93522657
88Bladder neoplasm (HP:0009725)1.93522657
89Nephroblastoma (Wilms tumor) (HP:0002667)1.93111448
90Prominent nose (HP:0000448)1.92937937
91Low posterior hairline (HP:0002162)1.90889700
92White forelock (HP:0002211)1.90584123
93Facial hemangioma (HP:0000329)1.90288563
94Pulmonary artery stenosis (HP:0004415)1.90037268
95Periodontitis (HP:0000704)1.89907832
96Abnormality of male internal genitalia (HP:0000022)1.89188435
97Papillary thyroid carcinoma (HP:0002895)1.88170701
98Abnormality of the metopic suture (HP:0005556)1.88141199
99Radioulnar synostosis (HP:0002974)1.87868552
100Meckel diverticulum (HP:0002245)1.87724072
101Cutaneous melanoma (HP:0012056)1.87523768
102Abnormality of the preputium (HP:0100587)1.86074422
103Oligodactyly (hands) (HP:0001180)1.83883892
104Agnosia (HP:0010524)1.82980636
105Obsessive-compulsive behavior (HP:0000722)1.82810483
106Abnormality of the columella (HP:0009929)1.82505516
107Upper limb muscle weakness (HP:0003484)1.82045452
108Insidious onset (HP:0003587)1.81832106
109Termporal pattern (HP:0011008)1.81832106
110Thyroiditis (HP:0100646)1.80704267
111Keratoconjunctivitis sicca (HP:0001097)1.80523547
112Neoplasm of the adrenal cortex (HP:0100641)1.80324782
113Glomerulopathy (HP:0100820)1.80311015
114Cortical dysplasia (HP:0002539)1.78602609
115Alveolar cell carcinoma (HP:0006519)1.77974853
116Pulmonary infiltrates (HP:0002113)1.77854077
117Short middle phalanx of the 5th finger (HP:0004220)1.77664954
118Muscle fiber atrophy (HP:0100295)1.77273146
119Abnormal lung lobation (HP:0002101)1.77216369
120Gaze-evoked nystagmus (HP:0000640)1.76889129
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.75028230
122Hypoplasia of the fovea (HP:0007750)1.75028230
123Embryonal renal neoplasm (HP:0011794)1.74836662
124Fair hair (HP:0002286)1.74663376
125Preaxial hand polydactyly (HP:0001177)1.73854328
126Abnormality of the renal collecting system (HP:0004742)1.73563911
127Abnormality of the phalanges of the 5th finger (HP:0004213)1.73427931
128Chronic obstructive pulmonary disease (HP:0006510)1.73233073
129Obstructive lung disease (HP:0006536)1.73233073
130Increased nuchal translucency (HP:0010880)1.72958467
131Prominent metopic ridge (HP:0005487)1.72902824
132Labial hypoplasia (HP:0000066)1.72690665
133Downturned corners of mouth (HP:0002714)1.71739853
134Impaired proprioception (HP:0010831)1.71157075
135Increased CSF protein (HP:0002922)1.71091783
136Supernumerary spleens (HP:0009799)1.70933991
13711 pairs of ribs (HP:0000878)1.70304643
138Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70252016
139Optic nerve coloboma (HP:0000588)1.70061576
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69963325
141Myelodysplasia (HP:0002863)1.69693842
142Neoplasm of the tracheobronchial system (HP:0100552)1.69494716
143Keratoconjunctivitis (HP:0001096)1.68288558
144Hyperglycemia (HP:0003074)1.67983094
145Pancreatic cysts (HP:0001737)1.67264164
146Nonprogressive disorder (HP:0003680)1.66658761
147IgM deficiency (HP:0002850)1.65916065
148Postaxial foot polydactyly (HP:0001830)1.65259206
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.64925282
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64925282
151Thick eyebrow (HP:0000574)1.64452180
152Hepatoblastoma (HP:0002884)1.63954166
153Anhidrosis (HP:0000970)1.63897399
154Dysmetric saccades (HP:0000641)1.63711810
155Cafe-au-lait spot (HP:0000957)1.63628759
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.63475052
157Long palpebral fissure (HP:0000637)1.63253455
158Metaphyseal dysplasia (HP:0100255)1.62234775
159Eczematoid dermatitis (HP:0000976)1.61626866
160Long clavicles (HP:0000890)1.61550230
161Blepharitis (HP:0000498)1.61336664
162Somatic mutation (HP:0001428)1.61150690
163Deep philtrum (HP:0002002)1.61063875
164Anencephaly (HP:0002323)1.60931455
165Lymphoma (HP:0002665)1.60829310
166Cutis marmorata (HP:0000965)1.60702374
167Abnormality of the femoral head (HP:0003368)1.60212029
168Premature loss of primary teeth (HP:0006323)1.59669639
169Abnormality of femoral epiphyses (HP:0006499)1.58754144
170Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.58754144
171Tetraparesis (HP:0002273)1.58479001
172Gonadotropin excess (HP:0000837)1.58444924
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.57593312
174Increased number of teeth (HP:0011069)1.57442181
175Hypoplastic iliac wings (HP:0002866)1.57279044
176Hypoplastic female external genitalia (HP:0012815)1.56349049
177Abnormality of the left ventricular outflow tract (HP:0011103)1.56128095
178Subaortic stenosis (HP:0001682)1.56128095
179Tapered finger (HP:0001182)1.55966734
180Gonadal dysgenesis (HP:0000133)1.55862953
181Fibular hypoplasia (HP:0003038)1.55630241
182Pulmonary fibrosis (HP:0002206)1.52706674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.59675728
2MAP3K143.53057911
3MKNK23.46473069
4TRIM282.91166568
5IRAK32.89893963
6TXK2.68586664
7MUSK2.59612119
8CAMK1G2.47653745
9PRPF4B2.45072909
10LATS12.32988576
11AKT32.25125533
12MKNK12.21541585
13SIK32.18156586
14TNIK2.03355981
15YES12.01200215
16CAMK1D1.92749031
17ZAK1.90412797
18ERBB31.89868073
19NLK1.84565620
20CHUK1.78524376
21IKBKB1.78401891
22BMPR21.77964642
23MAP3K101.70236072
24IRAK41.68184254
25TEC1.67208117
26PNCK1.67078905
27IKBKE1.64401657
28SGK21.62622799
29EEF2K1.57211401
30PIM11.53105697
31JAK31.46062800
32BMPR1B1.45763212
33EIF2AK31.41696429
34TRPM71.36627103
35CDK31.36510896
36PLK41.32965784
37NUAK11.26588333
38VRK11.24363427
39SRPK11.23630494
40CDK121.16053322
41MAP2K71.14851805
42EIF2AK11.13985248
43MAP3K91.13854007
44PIM21.13084862
45EIF2AK21.08285552
46MAP3K131.06707713
47TSSK61.06129181
48CDK61.05684066
49KSR11.05270035
50NEK61.04486984
51WEE11.01675774
52MAP3K61.01486318
53STK241.00455428
54CDK80.97925136
55CHEK10.96711499
56PLK30.96469699
57SGK30.95722715
58MAP4K10.94767111
59BRSK20.90860827
60MAP3K20.89802780
61BRAF0.89731604
62MTOR0.89572125
63MELK0.89503671
64ADRBK20.88631574
65TAOK30.84500831
66MAP3K30.84170302
67CLK10.84114138
68EPHA30.81047645
69PLK20.80898367
70STK38L0.79432974
71TTK0.78521938
72IRAK20.78354930
73TBK10.77655428
74CDK90.77208843
75EPHA20.74533309
76FLT30.73656693
77RPS6KB10.73466932
78KSR20.71760360
79CSNK1A1L0.71584517
80ATR0.70288397
81CDK70.69321960
82CCNB10.68389231
83FGFR30.66922142
84SGK4940.66473041
85SGK2230.66473041
86TIE10.65905319
87ACVR1B0.65621175
88KIT0.65616923
89STK100.65287833
90BTK0.65198763
91GRK10.64510198
92ZAP700.64410013
93CDC70.64150334
94MARK30.61919083
95JAK10.61089553
96RAF10.60999337
97FGFR20.60452572
98MAPK130.59393381
99FRK0.59244307
100IRAK10.58748270
101CHEK20.57649379
102MST40.56084607
103WNK10.55630355
104RPS6KA40.53194686
105CDK20.53127467
106SIK20.52822605
107MAP3K40.52440306
108PBK0.52122139
109MAPK100.51605033
110LCK0.51376435
111STK30.49949621
112PDGFRB0.49288597
113HIPK20.48547045
114MAPK70.47743593
115ATM0.47216413
116STK390.45999779
117MAPK10.45583522
118CSNK1G10.45495217
119DYRK1A0.45271185
120CDK10.45010564
121CDK40.44964393
122PRKAA10.44260746
123MAPK30.43822352
124NEK90.43529513
125ERBB40.43449341
126STK160.43230780
127RPS6KA60.43181667
128LYN0.43063904
129TYK20.41785154
130MAPK140.41753751
131BRD40.41506549
132BCR0.41247435
133GSK3B0.39829445
134PLK10.39420354
135MAPK150.39255664
136STK40.38971415
137MAPKAPK20.38164885
138RPS6KB20.38153032
139CSNK1D0.37512161
140FGFR10.37359276
141RPS6KL10.37353079
142RPS6KC10.37353079
143INSRR0.36692668
144RPS6KA50.36163481
145RPS6KA10.36079997
146CSNK1G20.35714615
147BRSK10.33843622
148PRKG20.33786616
149CSNK1G30.33732737
150CSK0.32906776

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21771671
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.07783244
3Fanconi anemia pathway_Homo sapiens_hsa034601.90173166
4Dorso-ventral axis formation_Homo sapiens_hsa043201.83990569
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83751422
6Basal transcription factors_Homo sapiens_hsa030221.75494078
7Measles_Homo sapiens_hsa051621.74443829
8Homologous recombination_Homo sapiens_hsa034401.72775811
9Non-small cell lung cancer_Homo sapiens_hsa052231.66641409
10Renal cell carcinoma_Homo sapiens_hsa052111.66271918
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62779311
12Non-homologous end-joining_Homo sapiens_hsa034501.62058667
13Protein export_Homo sapiens_hsa030601.61774064
14Allograft rejection_Homo sapiens_hsa053301.59541948
15ErbB signaling pathway_Homo sapiens_hsa040121.54233246
16Herpes simplex infection_Homo sapiens_hsa051681.53705784
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.52973447
18mTOR signaling pathway_Homo sapiens_hsa041501.52912469
19RNA degradation_Homo sapiens_hsa030181.52877480
20Mismatch repair_Homo sapiens_hsa034301.52345559
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52076325
22Graft-versus-host disease_Homo sapiens_hsa053321.50377434
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48202980
24Legionellosis_Homo sapiens_hsa051341.46134313
25Base excision repair_Homo sapiens_hsa034101.46061898
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43973845
27Primary immunodeficiency_Homo sapiens_hsa053401.42985145
28Pancreatic cancer_Homo sapiens_hsa052121.41293628
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40481415
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38989553
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37850944
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.37576304
33Leishmaniasis_Homo sapiens_hsa051401.37552846
34Type II diabetes mellitus_Homo sapiens_hsa049301.37171002
35DNA replication_Homo sapiens_hsa030301.37025892
36Inositol phosphate metabolism_Homo sapiens_hsa005621.34443954
37Influenza A_Homo sapiens_hsa051641.34150965
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34002537
39Rheumatoid arthritis_Homo sapiens_hsa053231.32004792
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31356517
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.30465306
42TNF signaling pathway_Homo sapiens_hsa046681.29692028
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29396816
44Glioma_Homo sapiens_hsa052141.28982533
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.25875166
46Autoimmune thyroid disease_Homo sapiens_hsa053201.24013462
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22689039
48Cell cycle_Homo sapiens_hsa041101.19438012
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19130048
50Bladder cancer_Homo sapiens_hsa052191.17717654
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16865198
52Lysine degradation_Homo sapiens_hsa003101.15387499
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13618442
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12900834
55Hematopoietic cell lineage_Homo sapiens_hsa046401.11019817
56p53 signaling pathway_Homo sapiens_hsa041151.09082825
57Malaria_Homo sapiens_hsa051441.07824153
58Hepatitis B_Homo sapiens_hsa051611.07019262
59Osteoclast differentiation_Homo sapiens_hsa043801.05106925
60Antigen processing and presentation_Homo sapiens_hsa046121.02356962
61Oocyte meiosis_Homo sapiens_hsa041141.01775102
62Sphingolipid signaling pathway_Homo sapiens_hsa040711.01187134
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01002969
64Acute myeloid leukemia_Homo sapiens_hsa052211.00559011
65Spliceosome_Homo sapiens_hsa030400.99678686
66Adherens junction_Homo sapiens_hsa045200.98657776
67Apoptosis_Homo sapiens_hsa042100.98373537
68Asthma_Homo sapiens_hsa053100.97595432
69Nucleotide excision repair_Homo sapiens_hsa034200.97246201
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97050317
71Toxoplasmosis_Homo sapiens_hsa051450.96168146
72Sphingolipid metabolism_Homo sapiens_hsa006000.94602992
73Phototransduction_Homo sapiens_hsa047440.93056291
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92735365
75Tuberculosis_Homo sapiens_hsa051520.91861524
76Prostate cancer_Homo sapiens_hsa052150.91815324
77Type I diabetes mellitus_Homo sapiens_hsa049400.91537401
78RNA polymerase_Homo sapiens_hsa030200.90161028
79Circadian rhythm_Homo sapiens_hsa047100.90078987
80Hepatitis C_Homo sapiens_hsa051600.88682345
81Selenocompound metabolism_Homo sapiens_hsa004500.87885213
82Epstein-Barr virus infection_Homo sapiens_hsa051690.87607905
83Proteoglycans in cancer_Homo sapiens_hsa052050.86525552
84Thyroid cancer_Homo sapiens_hsa052160.86137649
85Prolactin signaling pathway_Homo sapiens_hsa049170.86107445
86T cell receptor signaling pathway_Homo sapiens_hsa046600.83460603
87HTLV-I infection_Homo sapiens_hsa051660.82719520
88Choline metabolism in cancer_Homo sapiens_hsa052310.82703398
89One carbon pool by folate_Homo sapiens_hsa006700.82189000
90MicroRNAs in cancer_Homo sapiens_hsa052060.81043166
91RNA transport_Homo sapiens_hsa030130.79794225
92Other glycan degradation_Homo sapiens_hsa005110.76772220
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76478765
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74112734
95Estrogen signaling pathway_Homo sapiens_hsa049150.74005358
96Chemokine signaling pathway_Homo sapiens_hsa040620.73439491
97Insulin signaling pathway_Homo sapiens_hsa049100.73370273
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72492358
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70493106
100mRNA surveillance pathway_Homo sapiens_hsa030150.70037227
101Pertussis_Homo sapiens_hsa051330.69731440
102Viral carcinogenesis_Homo sapiens_hsa052030.69716441
103Insulin resistance_Homo sapiens_hsa049310.69656370
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69177229
105HIF-1 signaling pathway_Homo sapiens_hsa040660.67833240
106MAPK signaling pathway_Homo sapiens_hsa040100.67368976
107B cell receptor signaling pathway_Homo sapiens_hsa046620.67010525
108Salmonella infection_Homo sapiens_hsa051320.66883912
109AMPK signaling pathway_Homo sapiens_hsa041520.65738492
110Shigellosis_Homo sapiens_hsa051310.65563367
111FoxO signaling pathway_Homo sapiens_hsa040680.64121218
112TGF-beta signaling pathway_Homo sapiens_hsa043500.62414763
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62119400
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61390494
115Arachidonic acid metabolism_Homo sapiens_hsa005900.61352338
116Pyrimidine metabolism_Homo sapiens_hsa002400.61297526
117Notch signaling pathway_Homo sapiens_hsa043300.60074963
118Long-term depression_Homo sapiens_hsa047300.59334114
119Colorectal cancer_Homo sapiens_hsa052100.59326978
120Small cell lung cancer_Homo sapiens_hsa052220.58919164
121Phagosome_Homo sapiens_hsa041450.58509912
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57478328
123Melanoma_Homo sapiens_hsa052180.55963880
124Endometrial cancer_Homo sapiens_hsa052130.55557268
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.55434492
126Purine metabolism_Homo sapiens_hsa002300.53903873
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51826289
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51202169
129Pathways in cancer_Homo sapiens_hsa052000.49379211
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49345950
131Hippo signaling pathway_Homo sapiens_hsa043900.49298777
132African trypanosomiasis_Homo sapiens_hsa051430.49054705
133Chronic myeloid leukemia_Homo sapiens_hsa052200.48286639
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48133895
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47247308
136VEGF signaling pathway_Homo sapiens_hsa043700.46033119
137GnRH signaling pathway_Homo sapiens_hsa049120.45980687
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45197703
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44794536
140Wnt signaling pathway_Homo sapiens_hsa043100.44609513
141Long-term potentiation_Homo sapiens_hsa047200.44522465
142Hedgehog signaling pathway_Homo sapiens_hsa043400.43874530
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.40781528

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