ZBTB22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.54683984
2maternal placenta development (GO:0001893)3.80101298
3regulation of cholesterol homeostasis (GO:2000188)3.78873629
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77635865
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77635865
6regulation of translational fidelity (GO:0006450)3.77161140
7negative regulation of cell size (GO:0045792)3.69852519
8low-density lipoprotein particle clearance (GO:0034383)3.52139466
9regulation of fatty acid beta-oxidation (GO:0031998)3.36842415
10response to peptidoglycan (GO:0032494)3.36796593
11protein localization to endosome (GO:0036010)3.30061449
12positive regulation by symbiont of host defense response (GO:0052509)3.27677067
13modulation by symbiont of host defense response (GO:0052031)3.27677067
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27677067
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27677067
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.27677067
17modulation by symbiont of host immune response (GO:0052553)3.27677067
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.26269554
19mitotic G1 DNA damage checkpoint (GO:0031571)3.26078339
20heterochromatin organization (GO:0070828)3.25682533
21positive regulation of protein deacetylation (GO:0090312)3.23493014
22antigen processing and presentation of endogenous antigen (GO:0019883)3.21265571
23apoptotic cell clearance (GO:0043277)3.20003623
24apoptotic process involved in morphogenesis (GO:0060561)3.14630370
25pre-miRNA processing (GO:0031054)3.12607565
26macrophage activation involved in immune response (GO:0002281)3.08596071
27regulation of translational termination (GO:0006449)3.05743915
28regulation of cholesterol storage (GO:0010885)3.05166126
29pentose-phosphate shunt (GO:0006098)3.04245474
30germinal center formation (GO:0002467)3.02827756
31regulation of gamma-delta T cell differentiation (GO:0045586)2.99899546
32response to muramyl dipeptide (GO:0032495)2.99586623
33modulation by symbiont of host cellular process (GO:0044068)2.98058529
34adherens junction assembly (GO:0034333)2.96292151
35cell-substrate junction assembly (GO:0007044)2.96003758
36epithelial cell differentiation involved in prostate gland development (GO:0060742)2.95789838
37detection of other organism (GO:0098543)2.94926489
38positive regulation of triglyceride biosynthetic process (GO:0010867)2.94758903
39regulation of hippo signaling (GO:0035330)2.94266725
40mitotic G1/S transition checkpoint (GO:0044819)2.94082351
41activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.93917859
42barbed-end actin filament capping (GO:0051016)2.92978657
43response to laminar fluid shear stress (GO:0034616)2.92484217
44negative regulation of erythrocyte differentiation (GO:0045647)2.91627666
45regulation of T-helper 2 cell differentiation (GO:0045628)2.90610221
46peptidyl-lysine dimethylation (GO:0018027)2.90266139
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.86607367
48positive regulation of nuclease activity (GO:0032075)2.85877120
49detection of bacterium (GO:0016045)2.84946957
50cell-substrate adherens junction assembly (GO:0007045)2.82714997
51focal adhesion assembly (GO:0048041)2.82714997
52G1 DNA damage checkpoint (GO:0044783)2.82468816
53amyloid precursor protein catabolic process (GO:0042987)2.79559846
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.79245193
55regulation of chromatin binding (GO:0035561)2.79222166
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77446875
57regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77317418
58RNA stabilization (GO:0043489)2.76971041
59mRNA stabilization (GO:0048255)2.76971041
60regulation of extracellular matrix disassembly (GO:0010715)2.75417999
61positive regulation of cellular amide metabolic process (GO:0034250)2.72074748
62regulation of leukocyte degranulation (GO:0043300)2.69781664
63natural killer cell differentiation (GO:0001779)2.69709128
644-hydroxyproline metabolic process (GO:0019471)2.69068903
65lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66013574
66modulation by virus of host process (GO:0019054)2.65579538
67positive regulation of fatty acid beta-oxidation (GO:0032000)2.64875092
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64199598
69NADPH regeneration (GO:0006740)2.62743982
70regulation of NFAT protein import into nucleus (GO:0051532)2.60856293
71growth hormone receptor signaling pathway (GO:0060396)2.60724314
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60665851
73detection of external biotic stimulus (GO:0098581)2.60004177
74regulation of ARF protein signal transduction (GO:0032012)2.59032385
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58938275
76cytoplasmic mRNA processing body assembly (GO:0033962)2.58607886
77regulation of gamma-delta T cell activation (GO:0046643)2.58459980
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57694403
79detection of molecule of bacterial origin (GO:0032490)2.57644114
80regulation of interferon-beta biosynthetic process (GO:0045357)2.56650500
81regulation of nuclease activity (GO:0032069)2.56205396
82embryonic process involved in female pregnancy (GO:0060136)2.55874527
83alpha-linolenic acid metabolic process (GO:0036109)2.55241488
84COPI coating of Golgi vesicle (GO:0048205)2.54753870
85Golgi transport vesicle coating (GO:0048200)2.54753870
86pinocytosis (GO:0006907)2.54431755
87regulation of early endosome to late endosome transport (GO:2000641)2.54046059
88positive regulation of triglyceride metabolic process (GO:0090208)2.53566588
89negative regulation of lipid transport (GO:0032369)2.53428407
90positive thymic T cell selection (GO:0045059)2.53417900
91sexual reproduction (GO:0019953)2.52730954
92negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52646998
93regulation of ARF GTPase activity (GO:0032312)2.51882193
94negative regulation of cell killing (GO:0031342)2.51576878
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51576878
96receptor catabolic process (GO:0032801)2.50531700
97stress fiber assembly (GO:0043149)2.49587654
98NLS-bearing protein import into nucleus (GO:0006607)2.49535469
99plasma membrane repair (GO:0001778)2.49471985
100chromatin assembly (GO:0031497)2.48818066
101negative regulation of nucleotide catabolic process (GO:0030812)2.48657386
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48550415
103intracellular estrogen receptor signaling pathway (GO:0030520)2.48524280
104NIK/NF-kappaB signaling (GO:0038061)2.48148275
105trophectodermal cell differentiation (GO:0001829)2.46841482
106positive regulation of receptor recycling (GO:0001921)2.46058666
107negative regulation of cholesterol transport (GO:0032375)2.45292188
108negative regulation of sterol transport (GO:0032372)2.45292188
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44976537
110activation of JUN kinase activity (GO:0007257)2.44827997
111semaphorin-plexin signaling pathway (GO:0071526)2.43316300
112negative regulation of heart growth (GO:0061117)2.42972187
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.42972187
114cortical actin cytoskeleton organization (GO:0030866)2.42818497
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41463267
116negative regulation of interleukin-12 production (GO:0032695)2.40069194
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39855675
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37887485
119regulation of mast cell degranulation (GO:0043304)2.37700566
120endoplasmic reticulum unfolded protein response (GO:0030968)2.37474220
121labyrinthine layer blood vessel development (GO:0060716)2.37471762
122endothelial cell chemotaxis (GO:0035767)2.37306064
123detection of biotic stimulus (GO:0009595)2.36685442
124neutrophil activation involved in immune response (GO:0002283)2.36210975
125morphogenesis of an endothelium (GO:0003159)2.34753700
126endothelial tube morphogenesis (GO:0061154)2.34753700
127regulation of p38MAPK cascade (GO:1900744)2.34669155
128positive regulation of gamma-delta T cell activation (GO:0046645)2.34138361
129positive regulation of p38MAPK cascade (GO:1900745)2.33038467
130negative regulation of fatty acid transport (GO:2000192)2.32260357
131L-alpha-amino acid transmembrane transport (GO:1902475)2.31975402
132thymic T cell selection (GO:0045061)2.31287019
133protein-lipid complex assembly (GO:0065005)2.31176132
134sulfur amino acid catabolic process (GO:0000098)2.30204239
135establishment of apical/basal cell polarity (GO:0035089)2.30007835
136leukocyte aggregation (GO:0070486)2.29295036
137mannose metabolic process (GO:0006013)2.29135050
138cell-cell junction maintenance (GO:0045217)2.28270822
139activation of MAPKKK activity (GO:0000185)2.26908166
140regulation of lipid kinase activity (GO:0043550)2.26626056
141cellular response to virus (GO:0098586)2.25735866
142plasma lipoprotein particle clearance (GO:0034381)2.25007734
1432-oxoglutarate metabolic process (GO:0006103)2.24793585
144regulation of regulated secretory pathway (GO:1903305)2.23558142
145cellular response to unfolded protein (GO:0034620)2.23325848
146epithelial cell-cell adhesion (GO:0090136)2.23222906
147activation of Rac GTPase activity (GO:0032863)2.23093500
148fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22349149
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21362761
150regulation of glucose import in response to insulin stimulus (GO:2001273)2.20885352
151regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.20648133
152regulation of type I interferon-mediated signaling pathway (GO:0060338)2.20589663
153hemidesmosome assembly (GO:0031581)2.20321033
154protein localization to kinetochore (GO:0034501)2.20200943
155response to host (GO:0075136)2.19779461
156response to host defenses (GO:0052200)2.19779461
157response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.19779461
1583-UTR-mediated mRNA stabilization (GO:0070935)2.19220410
159positive regulation of Rap GTPase activity (GO:0032854)2.16901198
160immunoglobulin mediated immune response (GO:0016064)2.15698895
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.15473624
162regulation of macrophage cytokine production (GO:0010935)2.15218664
163cellular response to thyroid hormone stimulus (GO:0097067)2.14694763
164skin morphogenesis (GO:0043589)2.14628676
165regulation of defense response to virus by virus (GO:0050690)2.14475939
166regulation of necroptotic process (GO:0060544)2.13658869
167response to fluid shear stress (GO:0034405)2.13605951
168positive regulation of type 2 immune response (GO:0002830)2.13068397
169amyloid precursor protein metabolic process (GO:0042982)2.12769378
170signal complex assembly (GO:0007172)2.11738366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31210628
2MYC_22102868_ChIP-Seq_BL_Human3.17295178
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.67821399
4* VDR_21846776_ChIP-Seq_THP-1_Human2.63168538
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.53969458
6TCF7_22412390_ChIP-Seq_EML_Mouse2.49576051
7ZNF263_19887448_ChIP-Seq_K562_Human2.46518195
8KDM2B_26808549_Chip-Seq_DND41_Human2.43403173
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40730991
10LXR_22292898_ChIP-Seq_THP-1_Human2.35262475
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.32060539
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30097816
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27371111
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.21589530
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.16028633
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15647573
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.10793049
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09324686
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07781948
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99704953
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.91536325
22RACK7_27058665_Chip-Seq_MCF-7_Human1.86173084
23MAF_26560356_Chip-Seq_TH1_Human1.83829410
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78759223
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72256602
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67818762
27UTX_26944678_Chip-Seq_JUKART_Human1.66855478
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66289013
29KDM2B_26808549_Chip-Seq_K562_Human1.66265699
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.62576750
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.61133011
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59030039
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58902655
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58869452
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55651459
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55540534
37ATF3_27146783_Chip-Seq_COLON_Human1.54719115
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54437521
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.54272768
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54056321
41CLOCK_20551151_ChIP-Seq_293T_Human1.53529591
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50004695
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46286141
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46071413
45* VDR_24763502_ChIP-Seq_THP-1_Human1.43718200
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43371787
47NCOR1_26117541_ChIP-Seq_K562_Human1.42419091
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42397527
49* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41685332
50CREB1_26743006_Chip-Seq_LNCaP_Human1.39503706
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37551440
52P68_20966046_ChIP-Seq_HELA_Human1.37540321
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36562884
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36266674
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.32608371
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32488408
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.32239563
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.30809869
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30477412
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28702021
61SCL_19346495_ChIP-Seq_HPC-7_Human1.28583667
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.27360310
63BCOR_27268052_Chip-Seq_Bcells_Human1.27336211
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25758205
65MAF_26560356_Chip-Seq_TH2_Human1.25304226
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25271380
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25030523
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24533992
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24523793
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24026275
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23133243
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.20923619
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20785403
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.20590977
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.19558461
76GATA1_19941826_ChIP-Seq_K562_Human1.19310141
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18597715
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18203871
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18118927
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17985775
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16290916
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16181383
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15031519
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.13546208
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12993300
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.12861949
87TP53_22127205_ChIP-Seq_IMR90_Human1.12791589
88SPI1_23127762_ChIP-Seq_K562_Human1.12702313
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11662236
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.10301293
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10033836
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09978382
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09275263
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09161528
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08849188
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08118878
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07171817
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07047223
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06928786
100BCL6_27268052_Chip-Seq_Bcells_Human1.06044590
101CTCF_21964334_Chip-Seq_Bcells_Human1.05866762
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03929954
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.03603643
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03586486
105MYB_26560356_Chip-Seq_TH1_Human1.02305019
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.02134363
107SMC4_20622854_ChIP-Seq_HELA_Human1.02034798
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01480573
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01253474
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00965876
111GATA6_25053715_ChIP-Seq_YYC3_Human1.00705395
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00502948
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00090431
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99886186
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99188348
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99080031
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99076191
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98742951
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98740181
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98736662
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98565959
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97728836
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.97567238
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.97567238
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97263963
126CTCF_27219007_Chip-Seq_Bcells_Human0.96459826
127MYB_26560356_Chip-Seq_TH2_Human0.95407533
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94085172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.71344235
2MP0010352_gastrointestinal_tract_polyps3.02212147
3MP0010234_abnormal_vibrissa_follicle2.99326895
4MP0005076_abnormal_cell_differentiation2.84632509
5MP0009840_abnormal_foam_cell2.78910503
6MP0009278_abnormal_bone_marrow2.73285678
7MP0003300_gastrointestinal_ulcer2.72172602
8MP0003303_peritoneal_inflammation2.69225417
9MP0005451_abnormal_body_composition2.62739652
10MP0003566_abnormal_cell_adhesion2.35081786
11MP0005360_urolithiasis2.29281852
12MP0008260_abnormal_autophagy2.13055571
13MP0008961_abnormal_basal_metabolism2.03840144
14MP0002139_abnormal_hepatobiliary_system2.00322458
15MP0003724_increased_susceptibility_to1.97626368
16MP0003191_abnormal_cellular_cholesterol1.97168476
17MP0004185_abnormal_adipocyte_glucose1.93482623
18MP0002419_abnormal_innate_immunity1.85493418
19MP0005409_darkened_coat_color1.78200974
20MP0000685_abnormal_immune_system1.73957589
21MP0004510_myositis1.70725177
22MP0005025_abnormal_response_to1.65863361
23MP0001533_abnormal_skeleton_physiology1.65262778
24MP0001849_ear_inflammation1.65243730
25MP0001958_emphysema1.64497197
26MP0001835_abnormal_antigen_presentation1.63946155
27MP0005000_abnormal_immune_tolerance1.60290095
28MP0004947_skin_inflammation1.58268962
29MP0010307_abnormal_tumor_latency1.52329191
30MP0005023_abnormal_wound_healing1.49495529
31MP0002998_abnormal_bone_remodeling1.49390318
32MP0004858_abnormal_nervous_system1.49119720
33MP0001545_abnormal_hematopoietic_system1.44135458
34MP0005397_hematopoietic_system_phenotyp1.44135458
35MP0005058_abnormal_lysosome_morphology1.41787274
36MP0005666_abnormal_adipose_tissue1.41243454
37MP0003453_abnormal_keratinocyte_physiol1.41235679
38MP0009333_abnormal_splenocyte_physiolog1.41012934
39MP0003183_abnormal_peptide_metabolism1.39073081
40MP0006082_CNS_inflammation1.38105380
41MP0005083_abnormal_biliary_tract1.37749741
42MP0004130_abnormal_muscle_cell1.37051591
43MP0005365_abnormal_bile_salt1.31446199
44MP0003763_abnormal_thymus_physiology1.31081358
45MP0005257_abnormal_intraocular_pressure1.30782933
46MP0000609_abnormal_liver_physiology1.30523823
47MP0003436_decreased_susceptibility_to1.29985534
48MP0002723_abnormal_immune_serum1.28106688
49MP0002420_abnormal_adaptive_immunity1.25574964
50MP0002877_abnormal_melanocyte_morpholog1.25560066
51MP0001819_abnormal_immune_cell1.25080404
52MP0010329_abnormal_lipoprotein_level1.22288107
53MP0000767_abnormal_smooth_muscle1.21593016
54MP0002796_impaired_skin_barrier1.19747526
55MP0003690_abnormal_glial_cell1.18050312
56MP0002148_abnormal_hypersensitivity_rea1.18045137
57MP0008438_abnormal_cutaneous_collagen1.18034193
58MP0005085_abnormal_gallbladder_physiolo1.17192405
59MP0005375_adipose_tissue_phenotype1.16380817
60MP0002254_reproductive_system_inflammat1.15040757
61MP0000678_abnormal_parathyroid_gland1.14729216
62MP0002933_joint_inflammation1.13839918
63MP0003252_abnormal_bile_duct1.12659258
64MP0009785_altered_susceptibility_to1.11194647
65MP0004381_abnormal_hair_follicle1.10750231
66MP0000604_amyloidosis1.09861222
67MP0003172_abnormal_lysosome_physiology1.08300884
68MP0003091_abnormal_cell_migration1.08080771
69MP0001730_embryonic_growth_arrest1.07313442
70MP0008004_abnormal_stomach_pH1.06399928
71MP0005390_skeleton_phenotype1.04977874
72MP0010630_abnormal_cardiac_muscle1.04628681
73MP0004808_abnormal_hematopoietic_stem1.03125013
74MP0000733_abnormal_muscle_development1.02163605
75MP0002086_abnormal_extraembryonic_tissu0.99722316
76MP0005623_abnormal_meninges_morphology0.99469754
77MP0002138_abnormal_hepatobiliary_system0.99442199
78MP0005464_abnormal_platelet_physiology0.99407710
79MP0003828_pulmonary_edema0.98149170
80MP0004087_abnormal_muscle_fiber0.97236505
81MP0006054_spinal_hemorrhage0.96824421
82MP0005275_abnormal_skin_tensile0.96252480
83MP0003075_altered_response_to0.93976286
84MP0001348_abnormal_lacrimal_gland0.93918529
85MP0005501_abnormal_skin_physiology0.93274824
86MP0003656_abnormal_erythrocyte_physiolo0.92939660
87MP0004197_abnormal_fetal_growth/weight/0.92897455
88MP0001800_abnormal_humoral_immune0.92762231
89MP0000716_abnormal_immune_system0.92485177
90MP0001845_abnormal_inflammatory_respons0.92336861
91MP0002089_abnormal_postnatal_growth/wei0.91656760
92MP0000343_altered_response_to0.91439364
93MP0001915_intracranial_hemorrhage0.90445628
94MP0002060_abnormal_skin_morphology0.90258959
95MP0002269_muscular_atrophy0.89339473
96MP0000598_abnormal_liver_morphology0.88779385
97MP0002398_abnormal_bone_marrow0.88121443
98MP0008874_decreased_physiological_sensi0.87995785
99MP0004233_abnormal_muscle_weight0.87707266
100MP0001790_abnormal_immune_system0.87512362
101MP0005387_immune_system_phenotype0.87512362
102MP0008770_decreased_survivor_rate0.86825040
103MP0000747_muscle_weakness0.86690337
104MP0005166_decreased_susceptibility_to0.86604411
105MP0002249_abnormal_larynx_morphology0.86572031
106MP0005319_abnormal_enzyme/_coenzyme0.86230528
107MP0003045_fibrosis0.85437004
108MP0001851_eye_inflammation0.85389362
109MP0005167_abnormal_blood-brain_barrier0.85319379
110MP0003634_abnormal_glial_cell0.85111283
111MP0002088_abnormal_embryonic_growth/wei0.83460161
112MP0003984_embryonic_growth_retardation0.83201027
113MP0008469_abnormal_protein_level0.82460610
114MP0002722_abnormal_immune_system0.82362644
115MP0010155_abnormal_intestine_physiology0.81416232
116MP0001853_heart_inflammation0.81365623
117MP0003279_aneurysm0.81017936
118MP0003448_altered_tumor_morphology0.80820341
119MP0000689_abnormal_spleen_morphology0.80418832
120MP0002084_abnormal_developmental_patter0.79531441
121MP0000681_abnormal_thyroid_gland0.79497301
122MP0000003_abnormal_adipose_tissue0.78875885
123MP0000350_abnormal_cell_proliferation0.78384214
124MP0001672_abnormal_embryogenesis/_devel0.78081543
125MP0005380_embryogenesis_phenotype0.78081543
126MP0005671_abnormal_response_to0.77719599
127MP0001216_abnormal_epidermal_layer0.77482168
128MP0005310_abnormal_salivary_gland0.77362594
129MP0003329_amyloid_beta_deposits0.77266284
130MP0002080_prenatal_lethality0.77089781
131MP0002896_abnormal_bone_mineralization0.76484721
132MP0003795_abnormal_bone_structure0.76393097
133MP0000750_abnormal_muscle_regeneration0.76239024
134MP0001666_abnormal_nutrient_absorption0.75944883
135MP0002653_abnormal_ependyma_morphology0.75810703
136MP0002429_abnormal_blood_cell0.75582037
137MP0009931_abnormal_skin_appearance0.75385544
138MP0002452_abnormal_antigen_presenting0.75000869
139MP0001873_stomach_inflammation0.74624368
140MP0005670_abnormal_white_adipose0.74380494
141MP0001697_abnormal_embryo_size0.74217452
142MP0002925_abnormal_cardiovascular_devel0.74159840
143MP0002405_respiratory_system_inflammati0.73877790
144MP0000751_myopathy0.73471259
145MP0005410_abnormal_fertilization0.72776920
146MP0000858_altered_metastatic_potential0.72024991
147MP0002166_altered_tumor_susceptibility0.71075577

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.75471493
2Eczematoid dermatitis (HP:0000976)3.47418090
3Nasal polyposis (HP:0100582)3.41020480
4Obstructive sleep apnea (HP:0002870)3.34223972
5Abnormality of the nasal mucosa (HP:0000433)3.30147918
6Dysostosis multiplex (HP:0000943)3.22858751
7Hyperacusis (HP:0010780)3.21526636
8Ulnar bowing (HP:0003031)2.94760118
9Achilles tendon contracture (HP:0001771)2.88242125
10Abnormality of the Achilles tendon (HP:0005109)2.88062152
11Abnormality of macrophages (HP:0004311)2.83525782
12Deep venous thrombosis (HP:0002625)2.81344582
13Upper limb amyotrophy (HP:0009129)2.80837007
14Distal upper limb amyotrophy (HP:0007149)2.80837007
15Recurrent bacterial skin infections (HP:0005406)2.78970465
16Thin bony cortex (HP:0002753)2.78290880
17Abnormality of the lower motor neuron (HP:0002366)2.73064489
18Hand muscle atrophy (HP:0009130)2.72227386
19Recurrent abscess formation (HP:0002722)2.70731488
20Cervical subluxation (HP:0003308)2.70277896
21Abnormality of liposaccharide metabolism (HP:0010968)2.69525217
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.69525217
23Abnormality of glycolipid metabolism (HP:0010969)2.69525217
24Neurofibrillary tangles (HP:0002185)2.69284866
25Mucopolysacchariduria (HP:0008155)2.68767384
26Urinary glycosaminoglycan excretion (HP:0003541)2.68767384
27Abnormality of polysaccharide metabolism (HP:0011012)2.65986187
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65986187
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65986187
30Difficulty climbing stairs (HP:0003551)2.64496507
31Vertebral compression fractures (HP:0002953)2.62397628
32Broad face (HP:0000283)2.60650673
33Polycythemia (HP:0001901)2.54049944
34Increased connective tissue (HP:0009025)2.53448696
35Shallow orbits (HP:0000586)2.49263973
36Protrusio acetabuli (HP:0003179)2.46391013
37Reticulocytosis (HP:0001923)2.32534447
38Myositis (HP:0100614)2.30959295
39Xanthomatosis (HP:0000991)2.28825883
40Gingivitis (HP:0000230)2.27086190
41Aneurysm (HP:0002617)2.25692176
42J-shaped sella turcica (HP:0002680)2.22112482
43Hematochezia (HP:0002573)2.20625500
44Global brain atrophy (HP:0002283)2.19788865
45Mitral valve prolapse (HP:0001634)2.18690304
46Difficulty running (HP:0009046)2.18278976
47Asymmetric septal hypertrophy (HP:0001670)2.17862603
48Peritonitis (HP:0002586)2.17679723
49Increased density of long bones (HP:0006392)2.17526686
50Insomnia (HP:0100785)2.16053515
51Hyporeflexia of lower limbs (HP:0002600)2.15967336
52Orchitis (HP:0100796)2.15132211
53Turricephaly (HP:0000262)2.12795408
54Amyloidosis (HP:0011034)2.11692471
55Papilloma (HP:0012740)2.10545493
56Verrucae (HP:0200043)2.10545493
57Back pain (HP:0003418)2.10452129
58Myocardial infarction (HP:0001658)2.10374726
59Lymphangioma (HP:0100764)2.08926959
60Colitis (HP:0002583)2.08490780
61Segmental peripheral demyelination/remyelination (HP:0003481)2.07927697
62Ependymoma (HP:0002888)2.06670571
63Cellulitis (HP:0100658)2.06612322
64Chronic otitis media (HP:0000389)2.05292068
65Supranuclear gaze palsy (HP:0000605)2.05034317
66Nuclear cataract (HP:0100018)2.04986953
67Distal lower limb muscle weakness (HP:0009053)2.04553266
68Axonal loss (HP:0003447)2.04531508
69Joint stiffness (HP:0001387)2.04271101
70Increased variability in muscle fiber diameter (HP:0003557)2.02940405
71Spastic diplegia (HP:0001264)2.02925098
72Neuronal loss in central nervous system (HP:0002529)2.02880428
73Macroorchidism (HP:0000053)2.02121042
74Long toe (HP:0010511)2.01976922
75Flat acetabular roof (HP:0003180)2.01937872
76Fibroma (HP:0010614)2.01663975
77Recurrent gram-negative bacterial infections (HP:0005420)2.01419769
78Increased IgE level (HP:0003212)1.99929676
79Spontaneous hematomas (HP:0007420)1.99110264
80Bowing of the arm (HP:0006488)1.98982255
81Bowed forearm bones (HP:0003956)1.98982255
82Emphysema (HP:0002097)1.97385242
83Mitral regurgitation (HP:0001653)1.97001465
84Autoimmune thrombocytopenia (HP:0001973)1.96698841
85Multiple enchondromatosis (HP:0005701)1.96467516
86Systemic lupus erythematosus (HP:0002725)1.94354583
87Aortic aneurysm (HP:0004942)1.93514391
88Purpura (HP:0000979)1.93338317
89Interstitial pulmonary disease (HP:0006530)1.92341561
90Mediastinal lymphadenopathy (HP:0100721)1.91424582
91Increased cerebral lipofuscin (HP:0011813)1.90505609
92Elfin facies (HP:0004428)1.90466967
93Enlarged penis (HP:0000040)1.90430817
94Subacute progressive viral hepatitis (HP:0006572)1.90386557
95Fibrous tissue neoplasm (HP:0012316)1.90208916
96Biconcave vertebral bodies (HP:0004586)1.89935841
97Ankle contracture (HP:0006466)1.89710460
98Genu recurvatum (HP:0002816)1.87571655
99Obstructive lung disease (HP:0006536)1.87217882
100Chronic obstructive pulmonary disease (HP:0006510)1.87217882
101Gastrointestinal inflammation (HP:0004386)1.86839255
102Broad metatarsal (HP:0001783)1.85689495
103Polygenic inheritance (HP:0010982)1.84513464
104Abnormality of the thoracic spine (HP:0100711)1.84024537
105Fragile skin (HP:0001030)1.83330352
106Gastrointestinal infarctions (HP:0005244)1.83257396
107Esophageal varix (HP:0002040)1.82468168
108Pseudobulbar signs (HP:0002200)1.80763223
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.78761916
110Distal lower limb amyotrophy (HP:0008944)1.78631642
111Angiofibromas (HP:0010615)1.78588112
112Adenoma sebaceum (HP:0009720)1.78588112
113Dysmetric saccades (HP:0000641)1.77174155
114Asymmetry of the thorax (HP:0001555)1.76922580
115Basal cell carcinoma (HP:0002671)1.76634123
116Frequent falls (HP:0002359)1.75840190
117EMG: neuropathic changes (HP:0003445)1.75822177
118Renovascular hypertension (HP:0100817)1.75779324
119Cerebral inclusion bodies (HP:0100314)1.75548742
120Myoglobinuria (HP:0002913)1.75191870
121Heterotopia (HP:0002282)1.74513606
122Dilatation of the ascending aorta (HP:0005111)1.74354153
123Renal duplication (HP:0000075)1.74254524
124Increased CSF protein (HP:0002922)1.73329210
125Arterial tortuosity (HP:0005116)1.72991746
126Blue sclerae (HP:0000592)1.72696518
127Hypercortisolism (HP:0001578)1.72394917
128Increased mean platelet volume (HP:0011877)1.72385960
129Abnormality of skeletal muscle fiber size (HP:0012084)1.72186950
130Abnormal platelet volume (HP:0011876)1.72054544
131Right ventricular cardiomyopathy (HP:0011663)1.72031421
132Inflammation of the large intestine (HP:0002037)1.70624561
133Pustule (HP:0200039)1.69812451
134Hyperparathyroidism (HP:0000843)1.68744179
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68566418
136Vascular tortuosity (HP:0004948)1.66803400
137Bladder diverticulum (HP:0000015)1.66426077
138Spinal cord lesions (HP:0100561)1.65591132
139Syringomyelia (HP:0003396)1.65591132
140Hypochromic anemia (HP:0001931)1.65513092
141Stridor (HP:0010307)1.65444578
142Visceral angiomatosis (HP:0100761)1.65166352
143Astrocytoma (HP:0009592)1.64433660
144Abnormality of the astrocytes (HP:0100707)1.64433660
145Abnormality of the distal phalanges of the toes (HP:0010182)1.63982516
146Abnormality of complement system (HP:0005339)1.63908506
147Hypertensive crisis (HP:0100735)1.63437488
148Recurrent skin infections (HP:0001581)1.63216967
149Elevated erythrocyte sedimentation rate (HP:0003565)1.62797578
150Pointed chin (HP:0000307)1.62775805
151Thoracic kyphosis (HP:0002942)1.62705653
152Metaphyseal cupping (HP:0003021)1.62678909
153Disproportionate tall stature (HP:0001519)1.62556675
154Optic neuritis (HP:0100653)1.62479189
155Retrobulbar optic neuritis (HP:0100654)1.62479189
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.62340642
157Deformed sella turcica (HP:0002681)1.62292681
158Bowel diverticulosis (HP:0005222)1.62195673
159Bone pain (HP:0002653)1.61959945
160Prolonged bleeding time (HP:0003010)1.61325260
161Hemorrhage of the eye (HP:0011885)1.61081280
162Premature rupture of membranes (HP:0001788)1.60821761
163Rapidly progressive (HP:0003678)1.60627638
164Spondylolisthesis (HP:0003302)1.60339255
165Hypercholesterolemia (HP:0003124)1.60055965
166Loss of speech (HP:0002371)1.58654604
167Hemangiomatosis (HP:0007461)1.58544048
168Gastrointestinal stroma tumor (HP:0100723)1.58093330
169Overriding aorta (HP:0002623)1.56971508
170Rectal prolapse (HP:0002035)1.56474480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.83511101
2MAP3K104.20906241
3PKN23.97126061
4PRPF4B3.49750840
5EEF2K3.39781658
6ERN13.16301767
7ICK2.58691206
8RIPK42.40222067
9IRAK32.29447889
10PTK62.14098557
11CDK121.99832250
12SMG11.98804218
13TTN1.97252220
14RIPK11.97248470
15GRK61.88647546
16MAP4K11.87364500
17MAP3K131.81280476
18STK101.74276671
19LRRK21.71322417
20SIK11.60667864
21MARK21.48606998
22BLK1.47895479
23PRKD31.46302960
24IRAK21.42242156
25PDGFRA1.42169905
26EPHB11.40146759
27TAOK21.38985425
28NEK21.38317897
29BMX1.37610760
30TYRO31.35103790
31NME21.33305587
32SCYL21.30285314
33TNK21.29235112
34ALK1.28609326
35PAK41.26896259
36IRAK41.25483808
37MAP3K141.24714008
38TAOK11.19666622
39FGFR41.18733637
40TESK11.17840763
41CDC42BPA1.15635149
42KSR21.13688981
43EPHA21.07876273
44ARAF1.05641666
45MTOR1.03828394
46CDK60.96688777
47TYK20.96166282
48RET0.95716000
49MAP3K110.95622400
50MAP3K80.91179428
51PDK30.90428541
52PDK40.90428541
53MAP2K30.89937919
54DYRK1B0.89541272
55TGFBR20.89394217
56MAP3K60.88586582
57PTK20.87693864
58SIK20.87604024
59SIK30.87368603
60DDR20.85131754
61STK30.84723218
62MAPK120.84333740
63TBK10.84099915
64MAP3K90.83376098
65CSK0.80738899
66PAK20.78871858
67FES0.78404836
68FLT30.78336611
69LATS20.77062831
70MAPKAPK30.76987187
71MAP3K70.76905397
72NTRK10.76723438
73CDK40.76092982
74MAPK70.73189015
75MATK0.72859087
76JAK20.72749895
77HIPK20.72628018
78MAP3K20.71816508
79CAMKK10.71121428
80ZAP700.70233464
81CAMK1D0.70022539
82RPS6KA40.67523003
83IKBKE0.67470646
84PDGFRB0.66467845
85STK40.65146303
86PRKCH0.65142146
87CAMK1G0.64829033
88IRAK10.64273357
89PIM10.62817875
90JAK10.62606646
91MOS0.61530454
92NEK10.60434512
93RPS6KB20.59758624
94HCK0.57624131
95CSF1R0.56968348
96SGK30.56510679
97MAPK110.56354505
98DMPK0.55466821
99RPS6KA10.54937196
100IKBKB0.53823628
101MAP3K30.52517404
102PDK10.52272327
103PRKD20.52152363
104FGFR30.49975117
105JAK30.49950474
106MAP3K10.48302545
107TESK20.47928614
108PTK2B0.47513426
109PRKD10.47305308
110PIM20.47296829
111DAPK20.47208766
112BTK0.47171588
113EGFR0.46627000
114PRKG20.45720574
115SYK0.45344329
116RPS6KA20.45146189
117CHUK0.44763657
118STK110.43298576
119LMTK20.42829812
120MAP2K20.42192684
121FGR0.41831255
122PAK60.41431395
123MAPK40.39122671
124PDPK10.38929132
125RPS6KC10.38574374
126RPS6KL10.38574374
127BRAF0.38318946
128BCKDK0.37871793
129FGFR10.36360580
130ILK0.36232374
131RPS6KA60.35401770
132GSK3A0.35371964
133STK380.35212054

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90860230
2Other glycan degradation_Homo sapiens_hsa005112.65360008
3Nitrogen metabolism_Homo sapiens_hsa009102.44243917
4Chronic myeloid leukemia_Homo sapiens_hsa052201.89385859
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66012454
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65142194
7mTOR signaling pathway_Homo sapiens_hsa041501.61643428
8B cell receptor signaling pathway_Homo sapiens_hsa046621.60419838
9Insulin resistance_Homo sapiens_hsa049311.55638935
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54841863
11Arginine biosynthesis_Homo sapiens_hsa002201.54086147
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.51589326
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.46539053
14VEGF signaling pathway_Homo sapiens_hsa043701.43562144
15Acute myeloid leukemia_Homo sapiens_hsa052211.43528677
16Fatty acid biosynthesis_Homo sapiens_hsa000611.41467878
17Lysosome_Homo sapiens_hsa041421.39582382
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37669952
19Lysine degradation_Homo sapiens_hsa003101.33261769
20Non-small cell lung cancer_Homo sapiens_hsa052231.31729250
21Bladder cancer_Homo sapiens_hsa052191.25725730
22Osteoclast differentiation_Homo sapiens_hsa043801.22301659
23Fatty acid degradation_Homo sapiens_hsa000711.20697305
24PPAR signaling pathway_Homo sapiens_hsa033201.19949111
25Malaria_Homo sapiens_hsa051441.19495907
26Caffeine metabolism_Homo sapiens_hsa002321.19413813
27Bile secretion_Homo sapiens_hsa049761.18203935
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17892839
29AMPK signaling pathway_Homo sapiens_hsa041521.17860222
30Staphylococcus aureus infection_Homo sapiens_hsa051501.15590145
31Small cell lung cancer_Homo sapiens_hsa052221.14963927
32Hepatitis C_Homo sapiens_hsa051601.12336068
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12031139
34Dorso-ventral axis formation_Homo sapiens_hsa043201.11444709
35Proteoglycans in cancer_Homo sapiens_hsa052051.10505934
36Influenza A_Homo sapiens_hsa051641.10157233
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09512466
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.08669552
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.08594494
40Prion diseases_Homo sapiens_hsa050201.06954704
41GnRH signaling pathway_Homo sapiens_hsa049121.06918581
42Biosynthesis of amino acids_Homo sapiens_hsa012301.06589510
43Insulin signaling pathway_Homo sapiens_hsa049101.06437540
44ErbB signaling pathway_Homo sapiens_hsa040121.06210046
45Notch signaling pathway_Homo sapiens_hsa043301.06090249
46Glioma_Homo sapiens_hsa052141.05948652
47Pancreatic cancer_Homo sapiens_hsa052121.04699856
48Endometrial cancer_Homo sapiens_hsa052131.04571700
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03632958
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.03245363
51Toxoplasmosis_Homo sapiens_hsa051451.02323564
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01497177
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01352587
54Adherens junction_Homo sapiens_hsa045201.00848864
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00431878
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99770701
57Focal adhesion_Homo sapiens_hsa045100.98903777
58Selenocompound metabolism_Homo sapiens_hsa004500.97909874
59Chemokine signaling pathway_Homo sapiens_hsa040620.97833330
60Glucagon signaling pathway_Homo sapiens_hsa049220.97159282
61Fat digestion and absorption_Homo sapiens_hsa049750.96667906
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.96288030
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95798431
64Pertussis_Homo sapiens_hsa051330.95385913
65Allograft rejection_Homo sapiens_hsa053300.95214376
66Choline metabolism in cancer_Homo sapiens_hsa052310.94090053
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92491146
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.92295292
69Carbon metabolism_Homo sapiens_hsa012000.91333550
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89777149
71Salmonella infection_Homo sapiens_hsa051320.89714229
72Amoebiasis_Homo sapiens_hsa051460.89564460
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88964662
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88936872
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87894648
76Apoptosis_Homo sapiens_hsa042100.87675990
77Estrogen signaling pathway_Homo sapiens_hsa049150.86973829
78Inositol phosphate metabolism_Homo sapiens_hsa005620.86749020
79Fatty acid metabolism_Homo sapiens_hsa012120.86559303
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81790673
81Antigen processing and presentation_Homo sapiens_hsa046120.81787095
82Graft-versus-host disease_Homo sapiens_hsa053320.81428503
83Complement and coagulation cascades_Homo sapiens_hsa046100.81393042
84Phagosome_Homo sapiens_hsa041450.81273588
85Platelet activation_Homo sapiens_hsa046110.80962776
86Viral carcinogenesis_Homo sapiens_hsa052030.80805476
87Measles_Homo sapiens_hsa051620.80445319
88Autoimmune thyroid disease_Homo sapiens_hsa053200.80126466
89Colorectal cancer_Homo sapiens_hsa052100.79618458
90Viral myocarditis_Homo sapiens_hsa054160.78763268
91Leishmaniasis_Homo sapiens_hsa051400.77268489
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76939567
93Type II diabetes mellitus_Homo sapiens_hsa049300.76703539
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.76003831
95Endocytosis_Homo sapiens_hsa041440.75490013
96Prolactin signaling pathway_Homo sapiens_hsa049170.75400079
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74956528
98MicroRNAs in cancer_Homo sapiens_hsa052060.73694670
99Herpes simplex infection_Homo sapiens_hsa051680.73514532
100Prostate cancer_Homo sapiens_hsa052150.73461733
101Shigellosis_Homo sapiens_hsa051310.72122892
102Renal cell carcinoma_Homo sapiens_hsa052110.71838709
103HIF-1 signaling pathway_Homo sapiens_hsa040660.71249213
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70552508
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69214431
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67656318
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67285278
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.67019907
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.66832214
110Sulfur relay system_Homo sapiens_hsa041220.66704313
111Hepatitis B_Homo sapiens_hsa051610.65836839
112MAPK signaling pathway_Homo sapiens_hsa040100.65544090
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65176530
114Pentose phosphate pathway_Homo sapiens_hsa000300.63652220
115FoxO signaling pathway_Homo sapiens_hsa040680.63212328
116Pyruvate metabolism_Homo sapiens_hsa006200.61180238
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60964224
118T cell receptor signaling pathway_Homo sapiens_hsa046600.59942437
119ABC transporters_Homo sapiens_hsa020100.59716650
120Rap1 signaling pathway_Homo sapiens_hsa040150.59203859
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59169622
122Hippo signaling pathway_Homo sapiens_hsa043900.58710217
123HTLV-I infection_Homo sapiens_hsa051660.58649408
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58631081
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58576862
126Thyroid cancer_Homo sapiens_hsa052160.58052837
127Tryptophan metabolism_Homo sapiens_hsa003800.57958487
128Rheumatoid arthritis_Homo sapiens_hsa053230.57455516
129African trypanosomiasis_Homo sapiens_hsa051430.56895088
130Type I diabetes mellitus_Homo sapiens_hsa049400.56537271
131Long-term potentiation_Homo sapiens_hsa047200.54766154
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53912604
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53483312
134Glycerolipid metabolism_Homo sapiens_hsa005610.53289679
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52068169
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52040357
137TNF signaling pathway_Homo sapiens_hsa046680.51548834
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51335048
139Tuberculosis_Homo sapiens_hsa051520.51325362
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.49059934
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47486346

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