ZBTB25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.69724095
2ribosomal small subunit assembly (GO:0000028)5.18190476
3DNA deamination (GO:0045006)4.82844128
4L-fucose catabolic process (GO:0042355)4.78826022
5fucose catabolic process (GO:0019317)4.78826022
6L-fucose metabolic process (GO:0042354)4.78826022
7telomere maintenance via semi-conservative replication (GO:0032201)4.58816303
8indole-containing compound catabolic process (GO:0042436)4.43901468
9indolalkylamine catabolic process (GO:0046218)4.43901468
10tryptophan catabolic process (GO:0006569)4.43901468
11viral transcription (GO:0019083)4.34249336
12kynurenine metabolic process (GO:0070189)4.29497111
13DNA strand elongation involved in DNA replication (GO:0006271)4.24124762
14translational termination (GO:0006415)4.16195068
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13067265
16DNA replication initiation (GO:0006270)4.09095994
17DNA strand elongation (GO:0022616)4.08707674
18maturation of SSU-rRNA (GO:0030490)4.03400857
19tryptophan metabolic process (GO:0006568)4.01985467
20indolalkylamine metabolic process (GO:0006586)4.00682164
21telomere maintenance via recombination (GO:0000722)3.93044511
22positive regulation of gamma-delta T cell activation (GO:0046645)3.87135463
23DNA unwinding involved in DNA replication (GO:0006268)3.76890100
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76822342
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76521458
26interferon-gamma production (GO:0032609)3.72584512
27cotranslational protein targeting to membrane (GO:0006613)3.72015874
28ribosomal small subunit biogenesis (GO:0042274)3.69643234
29translational elongation (GO:0006414)3.67348897
30protein targeting to ER (GO:0045047)3.66783405
31response to pheromone (GO:0019236)3.63155837
32mitotic recombination (GO:0006312)3.60815397
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48486140
34protein localization to endoplasmic reticulum (GO:0070972)3.46193022
35telomere maintenance via telomere lengthening (GO:0010833)3.43389679
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.42146229
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41235564
38neural tube formation (GO:0001841)3.40360745
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36297219
40viral life cycle (GO:0019058)3.31226920
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25041054
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.25041054
43regulation of translation, ncRNA-mediated (GO:0045974)3.25041054
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21267991
45cellular ketone body metabolic process (GO:0046950)3.20411477
46cellular protein complex disassembly (GO:0043624)3.20283640
47negative regulation of mast cell activation (GO:0033004)3.19935947
48sulfation (GO:0051923)3.19481912
49negative regulation of telomere maintenance (GO:0032205)3.18650933
50protein K11-linked deubiquitination (GO:0035871)3.15243319
51indole-containing compound metabolic process (GO:0042430)3.14529249
52regulation of histone H3-K27 methylation (GO:0061085)3.08782290
53gamma-aminobutyric acid transport (GO:0015812)3.07368475
54ribosomal large subunit biogenesis (GO:0042273)3.05863942
55leukocyte aggregation (GO:0070486)3.05374992
56detection of light stimulus involved in visual perception (GO:0050908)3.03363437
57detection of light stimulus involved in sensory perception (GO:0050962)3.03363437
58rRNA catabolic process (GO:0016075)3.03017791
59translational initiation (GO:0006413)3.02244743
60lymphoid progenitor cell differentiation (GO:0002320)3.02155680
61pseudouridine synthesis (GO:0001522)3.00656164
62regulation of regulatory T cell differentiation (GO:0045589)2.98627506
63protein polyglutamylation (GO:0018095)2.98433957
64translesion synthesis (GO:0019985)2.97791044
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96631822
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96631822
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95824489
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94808085
69cellular biogenic amine catabolic process (GO:0042402)2.93407231
70amine catabolic process (GO:0009310)2.93407231
71water-soluble vitamin biosynthetic process (GO:0042364)2.90649578
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90345703
73isotype switching (GO:0045190)2.90345703
74somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90345703
75primary amino compound metabolic process (GO:1901160)2.88885726
76axoneme assembly (GO:0035082)2.87977174
77ketone body metabolic process (GO:1902224)2.87314112
78regulation of memory T cell differentiation (GO:0043380)2.86516652
79protein complex disassembly (GO:0043241)2.85098240
80nuclear-transcribed mRNA catabolic process (GO:0000956)2.84728817
81neuronal action potential (GO:0019228)2.84444917
82cAMP catabolic process (GO:0006198)2.84388959
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83340828
84DNA replication checkpoint (GO:0000076)2.82988644
85nonmotile primary cilium assembly (GO:0035058)2.81813382
86preassembly of GPI anchor in ER membrane (GO:0016254)2.81720789
87mast cell activation (GO:0045576)2.81143476
88regulation of hippo signaling (GO:0035330)2.80843565
89protein import into peroxisome matrix (GO:0016558)2.80050974
90positive regulation of defense response to virus by host (GO:0002230)2.79863309
91ribonucleoprotein complex biogenesis (GO:0022613)2.78042163
92antigen processing and presentation via MHC class Ib (GO:0002475)2.77195204
93epithelial cilium movement (GO:0003351)2.75500364
94activated T cell proliferation (GO:0050798)2.75008849
95mRNA catabolic process (GO:0006402)2.73912172
96CENP-A containing nucleosome assembly (GO:0034080)2.72930507
97mismatch repair (GO:0006298)2.72368850
98DNA synthesis involved in DNA repair (GO:0000731)2.71543083
99regulation of gamma-delta T cell differentiation (GO:0045586)2.71331619
100cornea development in camera-type eye (GO:0061303)2.71277837
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70635049
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.70635049
103NADH dehydrogenase complex assembly (GO:0010257)2.70635049
104NAD biosynthetic process (GO:0009435)2.70413946
105protein complex biogenesis (GO:0070271)2.70248420
106intra-S DNA damage checkpoint (GO:0031573)2.69890814
107somatic recombination of immunoglobulin gene segments (GO:0016447)2.68950382
108macromolecular complex disassembly (GO:0032984)2.67782011
109viral mRNA export from host cell nucleus (GO:0046784)2.67006189
110chromatin remodeling at centromere (GO:0031055)2.66904726
111platelet dense granule organization (GO:0060155)2.66295087
112kidney morphogenesis (GO:0060993)2.65992632
113response to interleukin-15 (GO:0070672)2.65507546
114serotonin metabolic process (GO:0042428)2.65020413
115negative T cell selection (GO:0043383)2.64751753
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64597355
117regulation of action potential (GO:0098900)2.63847483
118T cell homeostasis (GO:0043029)2.63277890
119tRNA methylation (GO:0030488)2.62538680
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62482413
121telomere maintenance (GO:0000723)2.62433208
122telomere organization (GO:0032200)2.62431945
123RNA catabolic process (GO:0006401)2.62035144
124rRNA processing (GO:0006364)2.61306621
125histone H2A acetylation (GO:0043968)2.61299647
126somatic diversification of immunoglobulins (GO:0016445)2.60904539
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.59566493
128regulation of gamma-delta T cell activation (GO:0046643)2.59498107
129somite development (GO:0061053)2.59090891
130definitive hemopoiesis (GO:0060216)2.58948059
131negative regulation of RNA splicing (GO:0033119)2.58913822
132reciprocal DNA recombination (GO:0035825)2.58739693
133reciprocal meiotic recombination (GO:0007131)2.58739693
134cellular response to interleukin-15 (GO:0071350)2.58683599
135spinal cord motor neuron differentiation (GO:0021522)2.57664098
136T cell migration (GO:0072678)2.57587659
137positive regulation of fatty acid transport (GO:2000193)2.57329997
138reflex (GO:0060004)2.57113423
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55942371
140somatic cell DNA recombination (GO:0016444)2.54513861
141somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.54513861
142purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53537669
1433-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53537669
144kinetochore organization (GO:0051383)2.53103194
145translation (GO:0006412)2.52136887
146rRNA metabolic process (GO:0016072)2.51679357
147fucosylation (GO:0036065)2.51180106
148somatic diversification of immune receptors (GO:0002200)2.50030555
149DNA replication-independent nucleosome organization (GO:0034724)2.49971213
150DNA replication-independent nucleosome assembly (GO:0006336)2.49971213
151cyclic nucleotide catabolic process (GO:0009214)2.48291623
152postreplication repair (GO:0006301)2.48273664
153histone mRNA metabolic process (GO:0008334)2.48143811
154negative thymic T cell selection (GO:0045060)2.47564174
155proteasome assembly (GO:0043248)2.47489232
156mitochondrial respiratory chain complex assembly (GO:0033108)2.47189104
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46936954
158cilium morphogenesis (GO:0060271)2.46182202
159dopamine transport (GO:0015872)2.45255787
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44534288
161piRNA metabolic process (GO:0034587)2.43935243
162cytidine metabolic process (GO:0046087)2.43870122
163cytidine catabolic process (GO:0006216)2.43870122
164cytidine deamination (GO:0009972)2.43870122
165cilium organization (GO:0044782)2.43516732
166establishment of integrated proviral latency (GO:0075713)2.43233328
167regulation of posttranscriptional gene silencing (GO:0060147)2.43114356
168regulation of gene silencing by miRNA (GO:0060964)2.43114356
169regulation of gene silencing by RNA (GO:0060966)2.43114356
170cilium or flagellum-dependent cell motility (GO:0001539)2.42974023
171cellular response to ATP (GO:0071318)2.42402928
172antigen processing and presentation of endogenous antigen (GO:0019883)2.42302145
173regulation of T cell receptor signaling pathway (GO:0050856)2.42215106
174regulation of cilium movement (GO:0003352)2.42155962
175respiratory chain complex IV assembly (GO:0008535)2.41228301
176positive regulation of oligodendrocyte differentiation (GO:0048714)2.40829268
177pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40751266
178mitotic cell cycle arrest (GO:0071850)2.40604201
179kinetochore assembly (GO:0051382)2.39966546
180regulation of B cell receptor signaling pathway (GO:0050855)2.39575057
181protein K48-linked deubiquitination (GO:0071108)2.39019465
182S-adenosylmethionine metabolic process (GO:0046500)2.38836966
183meiotic chromosome segregation (GO:0045132)2.38076516
184regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.37492521
185negative regulation of reactive oxygen species metabolic process (GO:2000378)2.37407927
186tolerance induction (GO:0002507)2.37097143
187positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36818813
188negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36188819
189endoderm formation (GO:0001706)2.36114343
190embryonic epithelial tube formation (GO:0001838)2.35644749
191interkinetic nuclear migration (GO:0022027)2.35289972
192regulation of telomere maintenance (GO:0032204)2.34770461
193positive regulation of mRNA catabolic process (GO:0061014)2.34612956
194benzene-containing compound metabolic process (GO:0042537)2.34605472
195behavioral response to ethanol (GO:0048149)2.34107084
196adenosine metabolic process (GO:0046085)2.33596113
197cilium assembly (GO:0042384)2.32913740
198pyrimidine ribonucleoside catabolic process (GO:0046133)2.31634200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26931592
2ZNF274_21170338_ChIP-Seq_K562_Hela3.91627085
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.43944096
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33243859
5VDR_22108803_ChIP-Seq_LS180_Human3.13158294
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93151022
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88407306
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.87338962
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85573154
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79761189
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.78775600
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77869546
13GBX2_23144817_ChIP-Seq_PC3_Human2.74928058
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69940015
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66794242
16EZH2_22144423_ChIP-Seq_EOC_Human2.60554852
17SCL_19346495_ChIP-Seq_HPC-7_Human2.58299900
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56306633
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54905741
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.54002607
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50774776
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48880190
23* VDR_23849224_ChIP-Seq_CD4+_Human2.47395360
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46204442
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44718677
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.37175491
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33686055
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32107132
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32095575
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31259455
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28325494
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27281710
33MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26857358
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25232351
35IGF1R_20145208_ChIP-Seq_DFB_Human2.24868333
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13271447
37EWS_26573619_Chip-Seq_HEK293_Human2.12892075
38MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12720304
39ETS1_20019798_ChIP-Seq_JURKAT_Human2.11158164
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09087133
41IRF8_22096565_ChIP-ChIP_GC-B_Human2.07830168
42MYC_22102868_ChIP-Seq_BL_Human2.07159218
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06304603
44FUS_26573619_Chip-Seq_HEK293_Human2.05280792
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04541217
46TAF15_26573619_Chip-Seq_HEK293_Human2.02612233
47HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02608999
48MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02463464
49ER_23166858_ChIP-Seq_MCF-7_Human2.00862116
50FOXP3_21729870_ChIP-Seq_TREG_Human2.00127591
51* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99677463
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98942781
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95558829
54XRN2_22483619_ChIP-Seq_HELA_Human1.92135280
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91603853
56CIITA_25753668_ChIP-Seq_RAJI_Human1.91586319
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.88208113
58P300_19829295_ChIP-Seq_ESCs_Human1.86902411
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85365322
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85057140
61SPI1_23547873_ChIP-Seq_NB4_Human1.84883012
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76823008
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76474287
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75193726
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.70707623
66VDR_21846776_ChIP-Seq_THP-1_Human1.70424058
67MYB_26560356_Chip-Seq_TH2_Human1.70275225
68ELK1_19687146_ChIP-ChIP_HELA_Human1.69519490
69DCP1A_22483619_ChIP-Seq_HELA_Human1.69352174
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69239391
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.68839162
72IRF1_19129219_ChIP-ChIP_H3396_Human1.67785589
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67641812
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67122948
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67033951
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65114813
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61610983
78GABP_19822575_ChIP-Seq_HepG2_Human1.59418738
79BCAT_22108803_ChIP-Seq_LS180_Human1.58747392
80TTF2_22483619_ChIP-Seq_HELA_Human1.57645150
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55277968
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55157617
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54776581
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.54436299
85STAT3_23295773_ChIP-Seq_U87_Human1.54342564
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54086391
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52364249
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51653902
89TP53_22573176_ChIP-Seq_HFKS_Human1.51227658
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50905082
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45738503
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44754586
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44523876
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44291226
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44233817
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44124530
97AR_21572438_ChIP-Seq_LNCaP_Human1.43676415
98* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43238493
99MYB_26560356_Chip-Seq_TH1_Human1.42835559
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.42636312
101RUNX_20019798_ChIP-Seq_JUKART_Human1.42328886
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41180082
103CBP_20019798_ChIP-Seq_JUKART_Human1.41180082
104AR_25329375_ChIP-Seq_VCAP_Human1.40052624
105TCF4_23295773_ChIP-Seq_U87_Human1.39731190
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38173356
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.38046281
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37907500
109SMAD4_21799915_ChIP-Seq_A2780_Human1.37020484
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36701395
111* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35932594
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34215778
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.33438670
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32554575
115* MAF_26560356_Chip-Seq_TH1_Human1.32468847
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32167294
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.31583390
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28834356
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.28834356
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27535196
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27420844
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27420844
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.26556954
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26048670
125* UTX_26944678_Chip-Seq_JUKART_Human1.25921409
126VDR_24763502_ChIP-Seq_THP-1_Human1.25892578
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.25876013
128REST_21632747_ChIP-Seq_MESCs_Mouse1.24403233
129* NANOG_19829295_ChIP-Seq_ESCs_Human1.23376490
130* SOX2_19829295_ChIP-Seq_ESCs_Human1.23376490
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.22837802
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.21170324
133CBX2_27304074_Chip-Seq_ESCs_Mouse1.20946766
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20422368
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19213920
136EGR1_19374776_ChIP-ChIP_THP-1_Human1.18519795
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17918924
138TCF4_22108803_ChIP-Seq_LS180_Human1.17572770
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17461617
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17298450
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.17137801
142* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17041052
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16792034
144* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16765294
145TP63_19390658_ChIP-ChIP_HaCaT_Human1.16082769
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15881128
147RNF2_27304074_Chip-Seq_NSC_Mouse1.15577014
148BP1_19119308_ChIP-ChIP_Hs578T_Human1.15017479
149RUNX2_22187159_ChIP-Seq_PCA_Human1.14359637
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13997560
151ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13554739
152ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12509315
153* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12064427
154MYC_18940864_ChIP-ChIP_HL60_Human1.11295331
155CRX_20693478_ChIP-Seq_RETINA_Mouse1.10876788
156* GATA3_26560356_Chip-Seq_TH2_Human1.10417001
157NCOR_22424771_ChIP-Seq_293T_Human1.09681406
158HOXB7_26014856_ChIP-Seq_BT474_Human1.08172921
159SMAD4_21741376_ChIP-Seq_EPCs_Human1.06816358
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06717716
161AR_20517297_ChIP-Seq_VCAP_Human1.06661771
162LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06632431
163IRF8_21731497_ChIP-ChIP_J774_Mouse1.05715909
164TP53_16413492_ChIP-PET_HCT116_Human1.05700939
165POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04987917
166EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04448832
167KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04160907
168SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03573326
169RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03355043
170NANOG_18555785_Chip-Seq_ESCs_Mouse1.01451100
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01437235
172P53_22387025_ChIP-Seq_ESCs_Mouse1.00570747
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00469148
174MAF_26560356_Chip-Seq_TH2_Human1.00340067
175FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99889132
176EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99529637
177TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99097118
178E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98401006
179SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97396909
180IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96649096
181* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96515780
182BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96376580
183* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95168549
184RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94452376
185* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94291776
186OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94290922
187TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92566667
188TFEB_21752829_ChIP-Seq_HELA_Human0.90915403
189GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89656422
190CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88680698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.86124912
2MP0003763_abnormal_thymus_physiology3.61816250
3MP0003195_calcinosis3.48771953
4MP0000569_abnormal_digit_pigmentation3.26031686
5MP0005671_abnormal_response_to3.15456823
6MP0008057_abnormal_DNA_replication2.90855873
7MP0010094_abnormal_chromosome_stability2.89167138
8MP0001835_abnormal_antigen_presentation2.82432327
9MP0008058_abnormal_DNA_repair2.57748428
10MP0000685_abnormal_immune_system2.51452653
11MP0008007_abnormal_cellular_replicative2.37879516
12MP0002398_abnormal_bone_marrow2.36125140
13MP0005174_abnormal_tail_pigmentation2.30990921
14MP0003693_abnormal_embryo_hatching2.30227144
15MP0002102_abnormal_ear_morphology2.28271705
16MP0003646_muscle_fatigue2.25845767
17MP0001800_abnormal_humoral_immune2.20063031
18MP0005551_abnormal_eye_electrophysiolog2.18353377
19MP0001968_abnormal_touch/_nociception2.18299269
20MP0005075_abnormal_melanosome_morpholog2.17519015
21MP0002420_abnormal_adaptive_immunity2.14413038
22MP0009785_altered_susceptibility_to2.11917222
23MP0005000_abnormal_immune_tolerance2.08736447
24MP0001819_abnormal_immune_cell2.08348742
25MP0004142_abnormal_muscle_tone2.07177312
26MP0002723_abnormal_immune_serum2.05434273
27MP0004808_abnormal_hematopoietic_stem2.03980782
28MP0003724_increased_susceptibility_to2.02996057
29MP0009333_abnormal_splenocyte_physiolog2.01393735
30MP0000703_abnormal_thymus_morphology2.00469877
31MP0009046_muscle_twitch1.99367025
32MP0002166_altered_tumor_susceptibility1.99013304
33MP0002452_abnormal_antigen_presenting1.97396143
34MP0000716_abnormal_immune_system1.95015553
35MP0009379_abnormal_foot_pigmentation1.92968138
36MP0000490_abnormal_crypts_of1.90941802
37MP0005387_immune_system_phenotype1.90800142
38MP0001790_abnormal_immune_system1.90800142
39MP0002837_dystrophic_cardiac_calcinosis1.87426883
40MP0002638_abnormal_pupillary_reflex1.86868624
41MP0003077_abnormal_cell_cycle1.86014407
42MP0009745_abnormal_behavioral_response1.85978102
43MP0004043_abnormal_pH_regulation1.83170814
44MP0002722_abnormal_immune_system1.82855669
45MP0002006_tumorigenesis1.80753150
46MP0002876_abnormal_thyroid_physiology1.79465954
47MP0000689_abnormal_spleen_morphology1.78783077
48MP0008872_abnormal_physiological_respon1.74916665
49MP0003787_abnormal_imprinting1.73083963
50MP0002429_abnormal_blood_cell1.72446963
51MP0000427_abnormal_hair_cycle1.72382016
52MP0002095_abnormal_skin_pigmentation1.70796100
53MP0005025_abnormal_response_to1.69377492
54MP0001545_abnormal_hematopoietic_system1.69148276
55MP0005397_hematopoietic_system_phenotyp1.69148276
56MP0008877_abnormal_DNA_methylation1.68273722
57MP0004885_abnormal_endolymph1.67646315
58MP0004957_abnormal_blastocyst_morpholog1.67142707
59MP0002736_abnormal_nociception_after1.66616405
60MP0002138_abnormal_hepatobiliary_system1.65711035
61MP0003866_abnormal_defecation1.61255749
62MP0005646_abnormal_pituitary_gland1.59307789
63MP0000465_gastrointestinal_hemorrhage1.58255041
64MP0001485_abnormal_pinna_reflex1.58025209
65MP0003111_abnormal_nucleus_morphology1.55017473
66MP0002148_abnormal_hypersensitivity_rea1.54850869
67MP0005253_abnormal_eye_physiology1.53281733
68MP0000631_abnormal_neuroendocrine_gland1.49575964
69MP0001853_heart_inflammation1.49292307
70MP0002405_respiratory_system_inflammati1.47853451
71MP0002933_joint_inflammation1.47704398
72MP0002272_abnormal_nervous_system1.46859790
73MP0001501_abnormal_sleep_pattern1.44300328
74MP0008875_abnormal_xenobiotic_pharmacok1.44022673
75MP0000015_abnormal_ear_pigmentation1.43933696
76MP0006292_abnormal_olfactory_placode1.43739624
77MP0004145_abnormal_muscle_electrophysio1.42499007
78MP0002419_abnormal_innate_immunity1.42372005
79MP0001873_stomach_inflammation1.42077348
80MP0001986_abnormal_taste_sensitivity1.41156889
81MP0003436_decreased_susceptibility_to1.38602135
82MP0005464_abnormal_platelet_physiology1.37124042
83MP0004742_abnormal_vestibular_system1.36781400
84MP0002132_abnormal_respiratory_system1.35846456
85MP0002928_abnormal_bile_duct1.34763525
86MP0003786_premature_aging1.34564612
87MP0002277_abnormal_respiratory_mucosa1.32759698
88MP0010155_abnormal_intestine_physiology1.32425592
89MP0003011_delayed_dark_adaptation1.31788723
90MP0002653_abnormal_ependyma_morphology1.29698590
91MP0004130_abnormal_muscle_cell1.28351763
92MP0000383_abnormal_hair_follicle1.27541264
93MP0001188_hyperpigmentation1.27014474
94MP0004924_abnormal_behavior1.26263411
95MP0005386_behavior/neurological_phenoty1.26263411
96MP0001486_abnormal_startle_reflex1.26077038
97MP0005409_darkened_coat_color1.23740763
98MP0000858_altered_metastatic_potential1.23219110
99MP0001919_abnormal_reproductive_system1.23023676
100MP0002064_seizures1.22682646
101MP0004133_heterotaxia1.22274515
102MP0005084_abnormal_gallbladder_morpholo1.21123387
103MP0005389_reproductive_system_phenotype1.18567542
104MP0002572_abnormal_emotion/affect_behav1.17754195
105MP0004381_abnormal_hair_follicle1.16398887
106MP0002019_abnormal_tumor_incidence1.14825293
107MP0002735_abnormal_chemical_nociception1.14692670
108MP0002557_abnormal_social/conspecific_i1.10123323
109MP0002163_abnormal_gland_morphology1.09288883
110MP0002067_abnormal_sensory_capabilities1.09192613
111MP0001984_abnormal_olfaction1.06749106
112MP0002009_preneoplasia1.05680385
113MP0008961_abnormal_basal_metabolism1.02326560
114MP0006276_abnormal_autonomic_nervous1.01622085
115MP0002160_abnormal_reproductive_system1.01078492
116MP0002733_abnormal_thermal_nociception0.99906444
117MP0003252_abnormal_bile_duct0.99354069
118MP0005379_endocrine/exocrine_gland_phen0.98245775
119MP0001502_abnormal_circadian_rhythm0.97962139
120MP0001970_abnormal_pain_threshold0.97208882
121MP0008932_abnormal_embryonic_tissue0.94535493
122MP0003635_abnormal_synaptic_transmissio0.94143470
123MP0000313_abnormal_cell_death0.93701022
124MP0010386_abnormal_urinary_bladder0.93120496
125MP0002210_abnormal_sex_determination0.92511675
126MP0002063_abnormal_learning/memory/cond0.92423471
127MP0001845_abnormal_inflammatory_respons0.91450279
128MP0002693_abnormal_pancreas_physiology0.91308704
129MP0003890_abnormal_embryonic-extraembry0.90905745
130MP0005377_hearing/vestibular/ear_phenot0.89283354
131MP0003878_abnormal_ear_physiology0.89283354
132MP0003283_abnormal_digestive_organ0.87541850
133MP0002075_abnormal_coat/hair_pigmentati0.87092051
134MP0001929_abnormal_gametogenesis0.85849196
135MP0000230_abnormal_systemic_arterial0.84120765
136MP0003137_abnormal_impulse_conducting0.81596721
137MP0005195_abnormal_posterior_eye0.81301209
138MP0003121_genomic_imprinting0.81032205
139MP0003567_abnormal_fetal_cardiomyocyte0.80199811
140MP0001905_abnormal_dopamine_level0.79632112
141MP0005167_abnormal_blood-brain_barrier0.78780502
142MP0002751_abnormal_autonomic_nervous0.78665841
143MP0005448_abnormal_energy_balance0.77551963
144MP0004215_abnormal_myocardial_fiber0.77438157
145MP0008995_early_reproductive_senescence0.77073377
146MP0000350_abnormal_cell_proliferation0.76888927
147MP0000538_abnormal_urinary_bladder0.74805307
148MP0003136_yellow_coat_color0.73583641
149MP0005645_abnormal_hypothalamus_physiol0.72259001
150MP0001324_abnormal_eye_pigmentation0.72104745
151MP0001529_abnormal_vocalization0.71077197
152MP0006082_CNS_inflammation0.69069342
153MP0000372_irregular_coat_pigmentation0.68847560
154MP0003172_abnormal_lysosome_physiology0.65476246
155MP0002089_abnormal_postnatal_growth/wei0.65401362
156MP0006072_abnormal_retinal_apoptosis0.65148578
157MP0001186_pigmentation_phenotype0.65140415
158MP0003943_abnormal_hepatobiliary_system0.64939956
159MP0001145_abnormal_male_reproductive0.64492970
160MP0004947_skin_inflammation0.63256757
161MP0004134_abnormal_chest_morphology0.62867508
162MP0005310_abnormal_salivary_gland0.62541054
163MP0004147_increased_porphyrin_level0.62510724
164MP0006054_spinal_hemorrhage0.62405884
165MP0002938_white_spotting0.60832860
166MP0003880_abnormal_central_pattern0.59809993
167MP0001533_abnormal_skeleton_physiology0.56840649
168MP0000653_abnormal_sex_gland0.56408891
169MP0003448_altered_tumor_morphology0.55289321
170MP0003183_abnormal_peptide_metabolism0.54584160
171MP0009697_abnormal_copulation0.54180836
172MP0003698_abnormal_male_reproductive0.53456482
173MP0009278_abnormal_bone_marrow0.52912905
174MP0001119_abnormal_female_reproductive0.52845050

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.60718834
2Abnormality of midbrain morphology (HP:0002418)4.17590326
3Molar tooth sign on MRI (HP:0002419)4.17590326
4Abnormal number of erythroid precursors (HP:0012131)4.04860283
5IgM deficiency (HP:0002850)3.95884852
6Aplastic anemia (HP:0001915)3.93451925
7Pancreatic fibrosis (HP:0100732)3.91149439
8Abnormality of cells of the erythroid lineage (HP:0012130)3.87124016
9Reticulocytopenia (HP:0001896)3.82942303
10Elevated erythrocyte sedimentation rate (HP:0003565)3.79145880
11True hermaphroditism (HP:0010459)3.76452485
12Congenital stationary night blindness (HP:0007642)3.70531538
13Nephronophthisis (HP:0000090)3.66399063
14Birth length less than 3rd percentile (HP:0003561)3.50220456
15Abnormality of the renal cortex (HP:0011035)3.45127279
16B lymphocytopenia (HP:0010976)3.42694718
17Abnormality of B cell number (HP:0010975)3.42694718
18Hyperventilation (HP:0002883)3.41720460
19Genetic anticipation (HP:0003743)3.35074581
20Myositis (HP:0100614)3.29733633
21Recurrent bronchitis (HP:0002837)3.24583438
22Abnormality of the renal medulla (HP:0100957)3.23205602
23Chronic otitis media (HP:0000389)3.17645815
24IgG deficiency (HP:0004315)3.10654972
25Type II lissencephaly (HP:0007260)3.01942954
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99520453
27Abnormality of alanine metabolism (HP:0010916)2.99520453
28Hyperalaninemia (HP:0003348)2.99520453
29Panhypogammaglobulinemia (HP:0003139)2.96880983
30Progressive cerebellar ataxia (HP:0002073)2.94633649
31Medial flaring of the eyebrow (HP:0010747)2.93931537
32Stomatitis (HP:0010280)2.90492212
33Type I transferrin isoform profile (HP:0003642)2.90426506
34Lymphoma (HP:0002665)2.89387306
35T lymphocytopenia (HP:0005403)2.88916027
36Gaze-evoked nystagmus (HP:0000640)2.86769464
37Attenuation of retinal blood vessels (HP:0007843)2.85778270
38Severe combined immunodeficiency (HP:0004430)2.83669387
39Pallor (HP:0000980)2.80477876
40Severe visual impairment (HP:0001141)2.78583643
41Chronic hepatic failure (HP:0100626)2.76518437
42Cystic liver disease (HP:0006706)2.75230274
43Inability to walk (HP:0002540)2.74716638
44Thrombocytosis (HP:0001894)2.74438960
45Abnormality of T cell number (HP:0011839)2.71027221
46Large for gestational age (HP:0001520)2.69955107
47Tubular atrophy (HP:0000092)2.67664035
48Abnormality of T cells (HP:0002843)2.65840230
49Renal cortical cysts (HP:0000803)2.64697927
50Retrobulbar optic neuritis (HP:0100654)2.59425743
51Optic neuritis (HP:0100653)2.59425743
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58154439
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58154439
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57968363
55Abnormality of the columella (HP:0009929)2.56162634
56Lymphopenia (HP:0001888)2.54678752
57Abolished electroretinogram (ERG) (HP:0000550)2.53655486
58Pancytopenia (HP:0001876)2.50752973
59Abnormal drinking behavior (HP:0030082)2.48921031
60Polydipsia (HP:0001959)2.48921031
61Chromsome breakage (HP:0040012)2.48535253
62Progressive inability to walk (HP:0002505)2.47859527
63Stomach cancer (HP:0012126)2.44672108
64Asplenia (HP:0001746)2.43854194
65Clumsiness (HP:0002312)2.43762136
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.42719320
67Furrowed tongue (HP:0000221)2.41961404
68Macrocytic anemia (HP:0001972)2.40580934
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40125727
70Pendular nystagmus (HP:0012043)2.35160948
71Decreased circulating renin level (HP:0003351)2.31875802
72Protruding tongue (HP:0010808)2.31247015
73Congenital, generalized hypertrichosis (HP:0004540)2.30527460
74Meningitis (HP:0001287)2.29845302
75Gait imbalance (HP:0002141)2.29201391
76Reduced antithrombin III activity (HP:0001976)2.28416966
77Abnormality of eosinophils (HP:0001879)2.27068809
78Combined immunodeficiency (HP:0005387)2.26444376
79Recurrent viral infections (HP:0004429)2.26130968
80Thyroiditis (HP:0100646)2.25540368
81Abnormality of T cell physiology (HP:0011840)2.23392766
82Congenital primary aphakia (HP:0007707)2.21733493
83Sclerocornea (HP:0000647)2.21405002
84Broad-based gait (HP:0002136)2.20710977
85Abnormality of chromosome stability (HP:0003220)2.20371630
86Patellar aplasia (HP:0006443)2.19630581
87Petechiae (HP:0000967)2.18827188
88Lissencephaly (HP:0001339)2.18089163
89Abnormality of DNA repair (HP:0003254)2.17302782
90Absent/shortened dynein arms (HP:0200106)2.15498072
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.15498072
92Abnormality of the pons (HP:0007361)2.15453982
93Congenital hepatic fibrosis (HP:0002612)2.15260567
94Prolonged bleeding time (HP:0003010)2.14763825
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.14475308
96Fair hair (HP:0002286)2.14458032
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.14453662
98Colon cancer (HP:0003003)2.14124932
99Abnormal protein N-linked glycosylation (HP:0012347)2.13761572
100Abnormal protein glycosylation (HP:0012346)2.13761572
101Abnormal glycosylation (HP:0012345)2.13761572
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13761572
103Gastrointestinal stroma tumor (HP:0100723)2.12934870
104Febrile seizures (HP:0002373)2.12133098
105Myelodysplasia (HP:0002863)2.12054292
106Cerebellar dysplasia (HP:0007033)2.11943782
107Eosinophilia (HP:0001880)2.09658780
108Hypothermia (HP:0002045)2.09633665
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.09421490
110Abnormality of the preputium (HP:0100587)2.09369893
111Aplasia/Hypoplasia of the patella (HP:0006498)2.09267191
112Decreased central vision (HP:0007663)2.08993246
113Medulloblastoma (HP:0002885)2.08816706
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.08090569
115Recurrent abscess formation (HP:0002722)2.07233383
116Hypoplasia of the pons (HP:0012110)2.06959011
117Agnosia (HP:0010524)2.05265310
118Basal cell carcinoma (HP:0002671)2.05249125
119Abnormality of the fingertips (HP:0001211)2.04169853
120Recurrent fungal infections (HP:0002841)2.03762533
121Meckel diverticulum (HP:0002245)2.03465872
122Orchitis (HP:0100796)2.02891097
123Vasculitis (HP:0002633)2.01752797
124Premature graying of hair (HP:0002216)2.01437060
125Anencephaly (HP:0002323)2.01347945
126Chronic sinusitis (HP:0011109)2.01038412
127Nephrogenic diabetes insipidus (HP:0009806)1.99921284
128Increased corneal curvature (HP:0100692)1.99771980
129Keratoconus (HP:0000563)1.99771980
130Amaurosis fugax (HP:0100576)1.99056701
131Bone marrow hypocellularity (HP:0005528)1.97608713
13211 pairs of ribs (HP:0000878)1.96805288
133Clubbing of toes (HP:0100760)1.96202206
134Recurrent sinusitis (HP:0011108)1.95853177
135Concave nail (HP:0001598)1.95431323
136Abnormality of the ileum (HP:0001549)1.95003815
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.94690347
138Methylmalonic acidemia (HP:0002912)1.94543009
139Poikiloderma (HP:0001029)1.93709962
140Polyuria (HP:0000103)1.92824751
141Granulocytopenia (HP:0001913)1.92597325
142Hypoplasia of the thymus (HP:0000778)1.92432115
143Mediastinal lymphadenopathy (HP:0100721)1.91991120
144Nasal polyposis (HP:0100582)1.91542581
145Acute lymphatic leukemia (HP:0006721)1.89952000
1463-Methylglutaconic aciduria (HP:0003535)1.89754534
147Severe muscular hypotonia (HP:0006829)1.89154962
148Abnormal number of incisors (HP:0011064)1.88748820
149Absent speech (HP:0001344)1.88709040
150Pulmonary fibrosis (HP:0002206)1.88526251
151Hypoproteinemia (HP:0003075)1.88491264
152Abnormal rod and cone electroretinograms (HP:0008323)1.87445315
153Chorioretinal atrophy (HP:0000533)1.87201539
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86357825
155Male pseudohermaphroditism (HP:0000037)1.86226648
156Hemiparesis (HP:0001269)1.85274722
157Chronic mucocutaneous candidiasis (HP:0002728)1.84943193
158Recurrent cutaneous fungal infections (HP:0011370)1.84943193
159Increased IgM level (HP:0003496)1.84067116
160Hepatocellular necrosis (HP:0001404)1.82745199
161Leukocytosis (HP:0001974)1.82712015
162Oral leukoplakia (HP:0002745)1.80937953
163Abnormal hair whorl (HP:0010721)1.80369159
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.79711327
165Widely spaced teeth (HP:0000687)1.79174198
166Irregular epiphyses (HP:0010582)1.78545055
167Recurrent pneumonia (HP:0006532)1.77886102
168Generalized hypopigmentation of hair (HP:0011358)1.77821192
169Dyskinesia (HP:0100660)1.77496293
170Bile duct proliferation (HP:0001408)1.77410990
171Abnormal biliary tract physiology (HP:0012439)1.77410990
172Acute myeloid leukemia (HP:0004808)1.77123948
173Bony spicule pigmentary retinopathy (HP:0007737)1.75005219
174Methylmalonic aciduria (HP:0012120)1.73971289
175Ketoacidosis (HP:0001993)1.73710943
176Genital tract atresia (HP:0001827)1.73387793
177Congenital sensorineural hearing impairment (HP:0008527)1.72709735
178Tachypnea (HP:0002789)1.71920028
179Pachygyria (HP:0001302)1.71850680
180Poor coordination (HP:0002370)1.71099857
181Vaginal atresia (HP:0000148)1.69428982
182Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69300380
183Ketosis (HP:0001946)1.67356463
184Aplasia/hypoplasia of the uterus (HP:0008684)1.64385139
185Abnormality of the renal collecting system (HP:0004742)1.63959749
186Postaxial foot polydactyly (HP:0001830)1.62360310
187Hypoalbuminemia (HP:0003073)1.60644630
188Abnormal albumin level (HP:0012116)1.60644630
189Absent thumb (HP:0009777)1.60075090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.93393536
2TNIK3.72769850
3TXK3.63469076
4MAP4K13.59999883
5STK163.24318819
6TAOK32.77245003
7ACVR1B2.69303823
8TEC2.54985227
9WEE12.36654942
10GRK12.31025082
11VRK12.24056492
12MAP4K22.13257130
13CDC72.12721304
14INSRR2.12196502
15WNK32.05086242
16SCYL22.02909793
17CDK192.02713428
18KIT1.99594832
19NUAK11.97060796
20BTK1.95666573
21WNK41.95395506
22NME21.80217898
23PINK11.70685962
24IRAK41.67670327
25ZAP701.67316692
26JAK31.66564335
27FLT31.64424006
28MAP3K121.60172958
29MKNK11.54494357
30ITK1.52322484
31IKBKE1.50807488
32PASK1.50717935
33PIM21.47387095
34SRPK11.47039849
35TSSK61.44280884
36BLK1.41921561
37DAPK21.39712001
38TLK11.39303554
39MAP3K41.39076509
40SIK31.35969551
41OXSR11.35242951
42ATR1.34382182
43CASK1.29801725
44CLK11.29235279
45SYK1.29069914
46LCK1.26784172
47EIF2AK11.25908554
48MKNK21.24176871
49EIF2AK31.22004771
50ADRBK11.19191376
51IRAK31.17576638
52MUSK1.16758574
53KDR1.13189604
54PAK31.13086935
55YES11.12294031
56CSF1R1.11941203
57STK391.10283431
58TGFBR11.08232939
59CDK81.06394016
60EPHA31.05721178
61MAP2K71.04638464
62LYN0.98617302
63SIK20.98406323
64GRK60.95708209
65NLK0.95706980
66STK100.94486361
67CDK70.94025496
68BRD40.93640652
69CDK40.91550607
70TBK10.91200725
71IKBKB0.90965848
72MAPK150.90244713
73PIM10.86717976
74DYRK30.85966506
75PHKG10.83275555
76PHKG20.83275555
77MAP3K100.83219462
78BMPR1B0.81844530
79BRSK20.81447125
80TYK20.79774424
81FGFR20.78934863
82PIK3CA0.78621373
83MAPKAPK50.78064842
84PRKCE0.77229918
85TGFBR20.76869162
86CAMKK10.75528983
87PTK2B0.74384829
88RPS6KA40.73818540
89ADRBK20.71109670
90DYRK20.70535386
91EEF2K0.70344287
92PNCK0.69781555
93ERBB30.69766650
94PRPF4B0.68776340
95RPS6KB20.67850181
96PRKCG0.67770562
97NEK20.67088636
98CHEK20.65165882
99AKT30.64675562
100MARK10.64409608
101STK38L0.64385768
102TRIM280.63524072
103RPS6KA50.63167554
104STK110.63075621
105TNK20.62265561
106HCK0.61013220
107BUB10.60821152
108EIF2AK20.59322541
109OBSCN0.58639507
110FES0.57773448
111NTRK20.57695207
112MAP3K140.57557718
113SGK20.57392706
114NTRK30.50591887
115DAPK10.50158687
116MAPKAPK30.49755974
117TRPM70.49290794
118MAP2K30.48936576
119MST40.48879427
120CCNB10.48446998
121PLK20.47855543
122MARK30.46348453
123TESK20.45526342
124PLK10.44657716
125PKN10.44508709
126GRK70.44355670
127WNK10.44349965
128PRKAA20.43996530
129CAMK10.43891453
130PRKAA10.43808293
131UHMK10.42539074
132AURKB0.41672015
133CHEK10.41441640
134MAPK40.41380144
135CSNK2A20.39804541
136MAP2K20.39494198
137CAMK2A0.39477507
138CAMK1D0.36617658
139PRKCQ0.36228836
140PRKACA0.36032084
141ATM0.35740027
142CSNK1D0.34927770
143CSNK2A10.34724350
144ZAK0.34714630
145CHUK0.34091060
146TAF10.33800829
147SGK2230.33799243
148SGK4940.33799243
149CDK30.33755747
150CAMKK20.33509172
151RPS6KA60.33043556
152CSNK1G30.32271050
153MAP3K70.32215715
154CSNK1G20.32174227
155IRAK10.32062558
156PRKCH0.31626420
157MAP2K60.31138499
158MAPK130.30890007
159MAPK30.30605538
160BCKDK0.28961128

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55273145
2Ribosome_Homo sapiens_hsa030103.56998043
3Mismatch repair_Homo sapiens_hsa034303.49265980
4Primary immunodeficiency_Homo sapiens_hsa053402.90695405
5Homologous recombination_Homo sapiens_hsa034402.79550914
6Linoleic acid metabolism_Homo sapiens_hsa005912.71478650
7Phototransduction_Homo sapiens_hsa047442.65609296
8Nitrogen metabolism_Homo sapiens_hsa009102.60715617
9Base excision repair_Homo sapiens_hsa034102.54870711
10Spliceosome_Homo sapiens_hsa030402.51710593
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50526263
12Non-homologous end-joining_Homo sapiens_hsa034502.44629939
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23619661
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22719563
15Nucleotide excision repair_Homo sapiens_hsa034202.22339605
16Nicotine addiction_Homo sapiens_hsa050332.19415636
17Selenocompound metabolism_Homo sapiens_hsa004502.15802518
18Fanconi anemia pathway_Homo sapiens_hsa034602.15780884
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06699358
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.97045038
21RNA polymerase_Homo sapiens_hsa030201.96470363
22Proteasome_Homo sapiens_hsa030501.93708053
23Butanoate metabolism_Homo sapiens_hsa006501.93499637
24Pyrimidine metabolism_Homo sapiens_hsa002401.84796417
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81855896
26Ether lipid metabolism_Homo sapiens_hsa005651.80687170
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73326994
28Tryptophan metabolism_Homo sapiens_hsa003801.69795279
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67564358
30Basal transcription factors_Homo sapiens_hsa030221.65517731
31Taste transduction_Homo sapiens_hsa047421.64131074
32Cell cycle_Homo sapiens_hsa041101.59921441
33Protein export_Homo sapiens_hsa030601.59782260
34RNA degradation_Homo sapiens_hsa030181.58428146
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56630933
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56419573
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53535702
38RNA transport_Homo sapiens_hsa030131.49082573
39Measles_Homo sapiens_hsa051621.48577220
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.48011488
41Morphine addiction_Homo sapiens_hsa050321.45622939
42ABC transporters_Homo sapiens_hsa020101.44421284
43Caffeine metabolism_Homo sapiens_hsa002321.41195328
44T cell receptor signaling pathway_Homo sapiens_hsa046601.40540791
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38622062
46Hematopoietic cell lineage_Homo sapiens_hsa046401.36254939
47Herpes simplex infection_Homo sapiens_hsa051681.35160367
48Antigen processing and presentation_Homo sapiens_hsa046121.32030759
49Olfactory transduction_Homo sapiens_hsa047401.30122536
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.30095762
51Regulation of autophagy_Homo sapiens_hsa041401.21367737
52One carbon pool by folate_Homo sapiens_hsa006701.18828884
53Allograft rejection_Homo sapiens_hsa053301.16260093
54Purine metabolism_Homo sapiens_hsa002301.12338947
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09590322
56Peroxisome_Homo sapiens_hsa041461.03288304
57p53 signaling pathway_Homo sapiens_hsa041151.02137764
58B cell receptor signaling pathway_Homo sapiens_hsa046621.01172476
59Epstein-Barr virus infection_Homo sapiens_hsa051691.01011832
60Arachidonic acid metabolism_Homo sapiens_hsa005901.00005699
61Insulin secretion_Homo sapiens_hsa049110.98665869
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98470102
63Shigellosis_Homo sapiens_hsa051310.98359882
64Leishmaniasis_Homo sapiens_hsa051400.98214656
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96493675
66Circadian entrainment_Homo sapiens_hsa047130.96198075
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.95591496
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95131178
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94746764
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.94616591
71Serotonergic synapse_Homo sapiens_hsa047260.93524900
72Chemical carcinogenesis_Homo sapiens_hsa052040.92931029
73mRNA surveillance pathway_Homo sapiens_hsa030150.92585817
74Glutamatergic synapse_Homo sapiens_hsa047240.91098026
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90315497
76GABAergic synapse_Homo sapiens_hsa047270.89664586
77Hepatitis B_Homo sapiens_hsa051610.89239465
78Ovarian steroidogenesis_Homo sapiens_hsa049130.88375776
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.87245804
80Calcium signaling pathway_Homo sapiens_hsa040200.86524067
81Dorso-ventral axis formation_Homo sapiens_hsa043200.85779476
82Autoimmune thyroid disease_Homo sapiens_hsa053200.83220413
83HTLV-I infection_Homo sapiens_hsa051660.83212659
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81245819
85Retinol metabolism_Homo sapiens_hsa008300.79304576
86Asthma_Homo sapiens_hsa053100.78871194
87Graft-versus-host disease_Homo sapiens_hsa053320.78497090
88Sulfur relay system_Homo sapiens_hsa041220.77732411
89Glycerolipid metabolism_Homo sapiens_hsa005610.77675017
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77164389
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76662521
92Circadian rhythm_Homo sapiens_hsa047100.76487375
93Propanoate metabolism_Homo sapiens_hsa006400.74533728
94Viral carcinogenesis_Homo sapiens_hsa052030.74256444
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73170061
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72985554
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71501867
98Osteoclast differentiation_Homo sapiens_hsa043800.70748516
99N-Glycan biosynthesis_Homo sapiens_hsa005100.69681832
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69427008
101Cardiac muscle contraction_Homo sapiens_hsa042600.68233165
102Systemic lupus erythematosus_Homo sapiens_hsa053220.65798191
103Legionellosis_Homo sapiens_hsa051340.65486173
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64881863
105Acute myeloid leukemia_Homo sapiens_hsa052210.63631006
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.62954832
107Salivary secretion_Homo sapiens_hsa049700.62877110
108Folate biosynthesis_Homo sapiens_hsa007900.62161618
109Viral myocarditis_Homo sapiens_hsa054160.61841999
110Alzheimers disease_Homo sapiens_hsa050100.57724708
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55239561
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54540675
113Colorectal cancer_Homo sapiens_hsa052100.53324218
114Dopaminergic synapse_Homo sapiens_hsa047280.51592584
115Cholinergic synapse_Homo sapiens_hsa047250.51347960
116Apoptosis_Homo sapiens_hsa042100.51283407
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50749061
118Amphetamine addiction_Homo sapiens_hsa050310.49429027
119Cocaine addiction_Homo sapiens_hsa050300.49261545
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48820051
121Malaria_Homo sapiens_hsa051440.48764829
122Long-term depression_Homo sapiens_hsa047300.48444306
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48378780
124Histidine metabolism_Homo sapiens_hsa003400.47730322
125Influenza A_Homo sapiens_hsa051640.45731984
126Type I diabetes mellitus_Homo sapiens_hsa049400.45428564
127Parkinsons disease_Homo sapiens_hsa050120.44368928
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44027330
129cAMP signaling pathway_Homo sapiens_hsa040240.43654061
130Pertussis_Homo sapiens_hsa051330.43465737
131beta-Alanine metabolism_Homo sapiens_hsa004100.42032040
132Mineral absorption_Homo sapiens_hsa049780.40803181
133Oxytocin signaling pathway_Homo sapiens_hsa049210.40708560
134Vitamin digestion and absorption_Homo sapiens_hsa049770.40686488
135Huntingtons disease_Homo sapiens_hsa050160.39843550
136Thyroid cancer_Homo sapiens_hsa052160.39820986
137Chemokine signaling pathway_Homo sapiens_hsa040620.39729253
138Salmonella infection_Homo sapiens_hsa051320.38557486
139Other glycan degradation_Homo sapiens_hsa005110.37529651
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37456814
141Alcoholism_Homo sapiens_hsa050340.37441320
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37202241
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.36792424
144Type II diabetes mellitus_Homo sapiens_hsa049300.36018640
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34468548
146Platelet activation_Homo sapiens_hsa046110.34259135
147Tuberculosis_Homo sapiens_hsa051520.33518497
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.33382921
149Collecting duct acid secretion_Homo sapiens_hsa049660.33366065
150Renin secretion_Homo sapiens_hsa049240.33159200
151Non-small cell lung cancer_Homo sapiens_hsa052230.32660264
152Small cell lung cancer_Homo sapiens_hsa052220.31652328
153Oxidative phosphorylation_Homo sapiens_hsa001900.31285512
154TNF signaling pathway_Homo sapiens_hsa046680.31225359
155Chronic myeloid leukemia_Homo sapiens_hsa052200.30351340
156Toxoplasmosis_Homo sapiens_hsa051450.29657592
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28789653
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28711097
159Pentose phosphate pathway_Homo sapiens_hsa000300.28323875
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28225437
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27866040
162Pancreatic cancer_Homo sapiens_hsa052120.27764928
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27736084
164Notch signaling pathway_Homo sapiens_hsa043300.24900310

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