ZBTB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.54474909
2cilium or flagellum-dependent cell motility (GO:0001539)8.34779105
3fusion of sperm to egg plasma membrane (GO:0007342)8.19373723
4motile cilium assembly (GO:0044458)8.08766171
5acrosome reaction (GO:0007340)7.60964578
6sperm-egg recognition (GO:0035036)7.20853662
7cell wall macromolecule catabolic process (GO:0016998)7.13788077
8cell wall macromolecule metabolic process (GO:0044036)7.13788077
9microtubule depolymerization (GO:0007019)7.12983970
10male meiosis (GO:0007140)6.96601962
11sperm motility (GO:0030317)6.87310433
12binding of sperm to zona pellucida (GO:0007339)6.74660249
13acrosome assembly (GO:0001675)6.61982771
14synaptonemal complex assembly (GO:0007130)6.52407852
15cell-cell recognition (GO:0009988)6.50644982
16spermatid development (GO:0007286)6.43265721
17synaptonemal complex organization (GO:0070193)6.36956246
18DNA methylation involved in gamete generation (GO:0043046)6.24123520
19plasma membrane fusion (GO:0045026)6.24053842
20multicellular organism reproduction (GO:0032504)6.23580931
21pre-miRNA processing (GO:0031054)6.16556070
22meiotic nuclear division (GO:0007126)5.79603974
23meiotic cell cycle (GO:0051321)5.69353946
24epithelial cilium movement (GO:0003351)5.67317830
25chromosome organization involved in meiosis (GO:0070192)5.56444529
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.30636666
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.25151252
28negative regulation of translation, ncRNA-mediated (GO:0040033)5.25151252
29regulation of translation, ncRNA-mediated (GO:0045974)5.25151252
30reproduction (GO:0000003)5.16593686
31male meiosis I (GO:0007141)5.12288099
32gene silencing by RNA (GO:0031047)5.10585424
33behavioral response to nicotine (GO:0035095)4.91006508
34meiosis I (GO:0007127)4.54942985
35cilium movement (GO:0003341)4.54639852
36cullin deneddylation (GO:0010388)4.33126013
37L-methionine salvage (GO:0071267)4.31750621
38L-methionine biosynthetic process (GO:0071265)4.31750621
39amino acid salvage (GO:0043102)4.31750621
40regulation of cilium movement (GO:0003352)4.21509139
41water-soluble vitamin biosynthetic process (GO:0042364)4.18990834
42protein deneddylation (GO:0000338)4.18788868
43spermatogenesis (GO:0007283)4.17830609
44male gamete generation (GO:0048232)4.16671642
45L-fucose catabolic process (GO:0042355)4.14288602
46fucose catabolic process (GO:0019317)4.14288602
47L-fucose metabolic process (GO:0042354)4.14288602
48protein-cofactor linkage (GO:0018065)4.07019215
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.06971765
50mitochondrial respiratory chain complex I assembly (GO:0032981)4.06971765
51NADH dehydrogenase complex assembly (GO:0010257)4.06971765
52protein complex biogenesis (GO:0070271)4.06616075
53single fertilization (GO:0007338)4.01282964
54mitochondrial respiratory chain complex assembly (GO:0033108)3.97815559
55lipid particle organization (GO:0034389)3.94880826
56regulation of meiosis I (GO:0060631)3.88178257
57sperm capacitation (GO:0048240)3.84923626
58gamete generation (GO:0007276)3.81891440
59germ cell development (GO:0007281)3.79583775
60meiotic cell cycle process (GO:1903046)3.76443613
61negative regulation of inclusion body assembly (GO:0090084)3.72318322
62regulation of histone H3-K9 methylation (GO:0051570)3.72232274
63pseudouridine synthesis (GO:0001522)3.70915592
64DNA deamination (GO:0045006)3.69270296
65fertilization (GO:0009566)3.67222194
66cellular process involved in reproduction in multicellular organism (GO:0022412)3.64476861
67maturation of SSU-rRNA (GO:0030490)3.64177971
68gene silencing (GO:0016458)3.63670864
69negative regulation of translational initiation (GO:0045947)3.62137377
70respiratory chain complex IV assembly (GO:0008535)3.58427066
71synapsis (GO:0007129)3.57983809
72negative regulation of telomere maintenance (GO:0032205)3.55292721
73microtubule polymerization or depolymerization (GO:0031109)3.54008558
74male genitalia development (GO:0030539)3.51959839
75mRNA cleavage (GO:0006379)3.48891973
76calcium ion-dependent exocytosis (GO:0017156)3.45483147
77ubiquinone biosynthetic process (GO:0006744)3.44971560
78negative regulation of DNA repair (GO:0045738)3.43150680
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42786959
80ATP synthesis coupled proton transport (GO:0015986)3.40997238
81energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40997238
82regulation of nuclear cell cycle DNA replication (GO:0033262)3.37974002
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33721902
84cytochrome complex assembly (GO:0017004)3.32461448
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32285034
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32285034
87ubiquinone metabolic process (GO:0006743)3.23079618
88nuclear pore complex assembly (GO:0051292)3.22658746
89reciprocal meiotic recombination (GO:0007131)3.22269817
90reciprocal DNA recombination (GO:0035825)3.22269817
91reproductive system development (GO:0061458)3.21154114
92positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.20236153
93regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.20236153
94chaperone-mediated protein transport (GO:0072321)3.18770366
95negative regulation of organelle assembly (GO:1902116)3.18743706
96termination of RNA polymerase III transcription (GO:0006386)3.18436085
97transcription elongation from RNA polymerase III promoter (GO:0006385)3.18436085
98methionine biosynthetic process (GO:0009086)3.17724056
99chaperone-mediated protein complex assembly (GO:0051131)3.15514405
100regulation of spindle checkpoint (GO:0090231)3.14355683
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.13953949
102kynurenine metabolic process (GO:0070189)3.09923357
103chromosome condensation (GO:0030261)3.09634636
104tRNA processing (GO:0008033)3.08974946
105DNA packaging (GO:0006323)3.06960276
106regulation of inclusion body assembly (GO:0090083)3.06661557
107S-adenosylmethionine metabolic process (GO:0046500)3.04964632
108nuclear pore organization (GO:0006999)3.04250733
109ventricular system development (GO:0021591)3.04077060
110regulation of centriole replication (GO:0046599)3.03186697
111tryptophan catabolic process (GO:0006569)3.02517265
112indole-containing compound catabolic process (GO:0042436)3.02517265
113indolalkylamine catabolic process (GO:0046218)3.02517265
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98898394
115DNA replication-dependent nucleosome organization (GO:0034723)2.98707194
116DNA replication-dependent nucleosome assembly (GO:0006335)2.98707194
117sister chromatid cohesion (GO:0007062)2.98526675
118protein K6-linked ubiquitination (GO:0085020)2.97579040
119peptidyl-histidine modification (GO:0018202)2.97337034
120nucleus organization (GO:0006997)2.96585773
121platelet dense granule organization (GO:0060155)2.96191950
122tRNA modification (GO:0006400)2.95084452
123preassembly of GPI anchor in ER membrane (GO:0016254)2.93880342
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93581942
125microtubule severing (GO:0051013)2.93317352
126multicellular organismal reproductive process (GO:0048609)2.91574092
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.88328446
128DNA replication checkpoint (GO:0000076)2.87016213
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86871517
130heterochromatin organization (GO:0070828)2.85837584
131positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.85652185
132regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.85652185
133histone exchange (GO:0043486)2.85135458
134protein-DNA complex disassembly (GO:0032986)2.84937128
135nucleosome disassembly (GO:0006337)2.84937128
136rRNA catabolic process (GO:0016075)2.84537216
137detection of light stimulus involved in visual perception (GO:0050908)2.84251310
138detection of light stimulus involved in sensory perception (GO:0050962)2.84251310
139electron transport chain (GO:0022900)2.83846619
140seminiferous tubule development (GO:0072520)2.83667004
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83505931
142sulfation (GO:0051923)2.81914706
143translesion synthesis (GO:0019985)2.81622728
144protein localization to chromosome, centromeric region (GO:0071459)2.81474967
145aspartate family amino acid biosynthetic process (GO:0009067)2.81164169
146cell recognition (GO:0008037)2.78796997
147respiratory electron transport chain (GO:0022904)2.78348085
148DNA alkylation (GO:0006305)2.77856102
149DNA methylation (GO:0006306)2.77856102
150indolalkylamine metabolic process (GO:0006586)2.77838782
151maturation of 5.8S rRNA (GO:0000460)2.76976020
152regulation of action potential (GO:0098900)2.76911246
153recombinational repair (GO:0000725)2.76098414
154double-strand break repair via homologous recombination (GO:0000724)2.74623920
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.74407616
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74407616
157protein K11-linked deubiquitination (GO:0035871)2.73910579
158regulation of hexokinase activity (GO:1903299)2.73288743
159regulation of glucokinase activity (GO:0033131)2.73288743
160quinone biosynthetic process (GO:1901663)2.69942428
161response to pheromone (GO:0019236)2.68447627
162negative regulation of mast cell activation (GO:0033004)2.67696526
163protein neddylation (GO:0045116)2.67564217
164regulation of gene silencing by RNA (GO:0060966)2.66587465
165regulation of posttranscriptional gene silencing (GO:0060147)2.66587465
166regulation of gene silencing by miRNA (GO:0060964)2.66587465
167cellular ketone body metabolic process (GO:0046950)2.64675195
168DNA double-strand break processing (GO:0000729)2.63996736
169kidney morphogenesis (GO:0060993)2.60933773
170tryptophan metabolic process (GO:0006568)2.60166414
171chromatin remodeling at centromere (GO:0031055)2.55043733
172regulation of mitochondrial translation (GO:0070129)2.54455066
173proteasome assembly (GO:0043248)2.54042045
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53779258
175regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53174477
176regulation of mitotic spindle checkpoint (GO:1903504)2.53174477
177mannosylation (GO:0097502)2.52438774
178protein polyglutamylation (GO:0018095)2.51926505
179replication fork processing (GO:0031297)2.51824029
180meiotic chromosome segregation (GO:0045132)2.51556905
181iron-sulfur cluster assembly (GO:0016226)2.50717672
182metallo-sulfur cluster assembly (GO:0031163)2.50717672
183base-excision repair, AP site formation (GO:0006285)2.50648349
184DNA damage response, detection of DNA damage (GO:0042769)2.50293966
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47340815
186regulation of mesoderm development (GO:2000380)2.44316884
187cilium morphogenesis (GO:0060271)2.44165762
188nonmotile primary cilium assembly (GO:0035058)2.43312424
189translational termination (GO:0006415)2.42278085
190piRNA metabolic process (GO:0034587)10.4576599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.46192771
2ZNF274_21170338_ChIP-Seq_K562_Hela3.91477236
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.52891404
4E2F7_22180533_ChIP-Seq_HELA_Human3.39604430
5VDR_22108803_ChIP-Seq_LS180_Human2.89024760
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71568138
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69440977
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65826115
9EWS_26573619_Chip-Seq_HEK293_Human2.48052664
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43190568
11GBX2_23144817_ChIP-Seq_PC3_Human2.40772846
12IGF1R_20145208_ChIP-Seq_DFB_Human2.29925352
13FUS_26573619_Chip-Seq_HEK293_Human2.18426468
14EZH2_22144423_ChIP-Seq_EOC_Human2.17847486
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.10718051
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06241853
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03188204
18MYC_18940864_ChIP-ChIP_HL60_Human2.02945695
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01003138
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.00577285
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5181719
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92992462
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92753460
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91694679
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90825266
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90404936
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.89982809
28IRF1_19129219_ChIP-ChIP_H3396_Human1.89286350
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88628965
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87914806
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84413144
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83925200
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.83918783
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83413932
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82283614
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82102177
37TAF15_26573619_Chip-Seq_HEK293_Human1.79791067
38P300_19829295_ChIP-Seq_ESCs_Human1.79046540
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74302138
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.70950162
41TP53_22573176_ChIP-Seq_HFKS_Human1.69496073
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68887982
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68700621
44ER_23166858_ChIP-Seq_MCF-7_Human1.64253133
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63644929
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60465472
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60165003
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59905628
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.59760697
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58872969
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.56489245
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55931636
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54952965
54ELK1_19687146_ChIP-ChIP_HELA_Human1.52300290
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51616253
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51419405
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49086790
58GABP_19822575_ChIP-Seq_HepG2_Human1.44936371
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43848370
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.42766710
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38801755
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38757879
63VDR_23849224_ChIP-Seq_CD4+_Human1.34698545
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32773293
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32771703
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32358874
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32258915
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31946980
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31810384
70BCAT_22108803_ChIP-Seq_LS180_Human1.31440705
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30087447
72GATA3_21867929_ChIP-Seq_CD8_Mouse1.30006374
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.29434586
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29434586
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.28566348
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.28549563
77FOXP3_21729870_ChIP-Seq_TREG_Human1.27537037
78* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26936023
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.25840466
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.24600862
81* XRN2_22483619_ChIP-Seq_HELA_Human1.24245217
82NCOR_22424771_ChIP-Seq_293T_Human1.23614203
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22991092
84SOX2_19829295_ChIP-Seq_ESCs_Human1.21900583
85NANOG_19829295_ChIP-Seq_ESCs_Human1.21900583
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20945207
87AR_20517297_ChIP-Seq_VCAP_Human1.20779394
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20666514
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20215597
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.19949568
91CBP_20019798_ChIP-Seq_JUKART_Human1.19529509
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19529509
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.18724789
94REST_21632747_ChIP-Seq_MESCs_Mouse1.17240266
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16967834
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14660137
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14625868
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.14213066
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13857347
100RNF2_27304074_Chip-Seq_NSC_Mouse1.13428835
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13248986
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13129941
103TCF4_22108803_ChIP-Seq_LS180_Human1.10335102
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10006469
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08784043
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06885485
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.05963444
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.05801354
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05697823
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05658412
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.05404803
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04865450
113CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04329798
114* TAF2_19829295_ChIP-Seq_ESCs_Human1.04148026
115TCF4_23295773_ChIP-Seq_U87_Human1.04005588
116DCP1A_22483619_ChIP-Seq_HELA_Human1.02842444
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.02780295
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02705839
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02630721
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.02502360
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02342990
122KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01922883
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01017946
124E2F1_21310950_ChIP-Seq_MCF-7_Human1.00457816
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99982282
126AR_25329375_ChIP-Seq_VCAP_Human0.99862762
127STAT3_23295773_ChIP-Seq_U87_Human0.99487443
128HOXB7_26014856_ChIP-Seq_BT474_Human0.99100963
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99092049
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.98782197
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98518830
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97951399
133RUNX2_22187159_ChIP-Seq_PCA_Human0.97928806
134PHF8_20622854_ChIP-Seq_HELA_Human0.97916951
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97237788
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96318194
137LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.96042824
138KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96040055
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95689857
140E2F1_20622854_ChIP-Seq_HELA_Human0.94479842
141NANOG_20526341_ChIP-Seq_ESCs_Human0.94313140
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94263311
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94212108
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93813314
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93690483
146KDM5A_27292631_Chip-Seq_BREAST_Human0.93598854
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.93162262
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.92820104
149* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92008069
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.91397619
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.91098216
152SMAD4_21799915_ChIP-Seq_A2780_Human0.90279149
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89640622
154EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89590024
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89580290
156TTF2_22483619_ChIP-Seq_HELA_Human0.89197681
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89027864
158RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88807058
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87769100
160* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86297050
161GATA1_26923725_Chip-Seq_HPCs_Mouse0.83286136
162* RUNX1_22412390_ChIP-Seq_EML_Mouse0.83244391
163ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83229352
164ERA_21632823_ChIP-Seq_H3396_Human0.82733135
165RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82396682
166KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82234870
167GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.81993804
168PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81859804
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81569664
170RARB_24833708_ChIP-Seq_LIVER_Mouse0.80873945
171ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80558146
172* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80141230
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79643431
174TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79643431
175TP53_22127205_ChIP-Seq_IMR90_Human0.79418256
176BCL6_27268052_Chip-Seq_Bcells_Human0.79207165
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79142164
178* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78925594
179RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78559533
180POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77166400
181* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76787203
182YY1_22570637_ChIP-Seq_MALME-3M_Human0.76786421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.92079522
2MP0001929_abnormal_gametogenesis4.31516689
3MP0003698_abnormal_male_reproductive4.08271986
4MP0008877_abnormal_DNA_methylation4.07700834
5MP0005409_darkened_coat_color3.82244579
6MP0010094_abnormal_chromosome_stability3.81434765
7MP0002653_abnormal_ependyma_morphology3.66493453
8MP0002210_abnormal_sex_determination3.06611726
9MP0003111_abnormal_nucleus_morphology3.02051088
10MP0008058_abnormal_DNA_repair2.95417243
11MP0001145_abnormal_male_reproductive2.93570105
12MP0005174_abnormal_tail_pigmentation2.91550732
13MP0000015_abnormal_ear_pigmentation2.64181092
14MP0000653_abnormal_sex_gland2.38878175
15MP0008057_abnormal_DNA_replication2.38082600
16MP0003195_calcinosis2.31741085
17MP0005551_abnormal_eye_electrophysiolog2.31304434
18MP0003693_abnormal_embryo_hatching2.31186157
19MP0006072_abnormal_retinal_apoptosis2.29631847
20MP0001968_abnormal_touch/_nociception2.27779392
21MP0002161_abnormal_fertility/fecundity2.22713951
22MP0002163_abnormal_gland_morphology2.21055554
23MP0004957_abnormal_blastocyst_morpholog2.15686200
24MP0002736_abnormal_nociception_after2.12514107
25MP0003077_abnormal_cell_cycle2.10423138
26MP0002837_dystrophic_cardiac_calcinosis2.07478217
27MP0003011_delayed_dark_adaptation2.05113433
28MP0009046_muscle_twitch2.04764620
29MP0005645_abnormal_hypothalamus_physiol2.01473408
30MP0004808_abnormal_hematopoietic_stem1.97282250
31MP0010307_abnormal_tumor_latency1.94615985
32MP0004133_heterotaxia1.92879203
33MP0005084_abnormal_gallbladder_morpholo1.90778706
34MP0005646_abnormal_pituitary_gland1.86217836
35MP0003136_yellow_coat_color1.80223788
36MP0008875_abnormal_xenobiotic_pharmacok1.78504742
37MP0003890_abnormal_embryonic-extraembry1.76499098
38MP0005253_abnormal_eye_physiology1.76045905
39MP0002938_white_spotting1.73596261
40MP0003567_abnormal_fetal_cardiomyocyte1.72803237
41MP0004142_abnormal_muscle_tone1.71490339
42MP0002876_abnormal_thyroid_physiology1.65648991
43MP0009745_abnormal_behavioral_response1.63198568
44MP0003123_paternal_imprinting1.62407691
45MP0002638_abnormal_pupillary_reflex1.60885290
46MP0004147_increased_porphyrin_level1.60679915
47MP0000358_abnormal_cell_content/1.58537498
48MP0010352_gastrointestinal_tract_polyps1.56294199
49MP0004043_abnormal_pH_regulation1.53860633
50MP0002160_abnormal_reproductive_system1.52238336
51MP0000631_abnormal_neuroendocrine_gland1.50755882
52MP0001730_embryonic_growth_arrest1.47883563
53MP0002272_abnormal_nervous_system1.46163964
54MP0004233_abnormal_muscle_weight1.44796182
55MP0000427_abnormal_hair_cycle1.41789693
56MP0003880_abnormal_central_pattern1.39213716
57MP0003937_abnormal_limbs/digits/tail_de1.38669637
58MP0002102_abnormal_ear_morphology1.38301640
59MP0006276_abnormal_autonomic_nervous1.37685890
60MP0002269_muscular_atrophy1.36601727
61MP0000569_abnormal_digit_pigmentation1.36569134
62MP0003646_muscle_fatigue1.34710059
63MP0005380_embryogenesis_phenotype1.32604403
64MP0001672_abnormal_embryogenesis/_devel1.32604403
65MP0000747_muscle_weakness1.29356691
66MP0001697_abnormal_embryo_size1.28465959
67MP0000350_abnormal_cell_proliferation1.27963595
68MP0003984_embryonic_growth_retardation1.27291594
69MP0001485_abnormal_pinna_reflex1.27247973
70MP0005623_abnormal_meninges_morphology1.26610322
71MP0006035_abnormal_mitochondrial_morpho1.24524559
72MP0001188_hyperpigmentation1.23370398
73MP0008007_abnormal_cellular_replicative1.23187703
74MP0002254_reproductive_system_inflammat1.23075848
75MP0002088_abnormal_embryonic_growth/wei1.19661199
76MP0005075_abnormal_melanosome_morpholog1.18717261
77MP0000313_abnormal_cell_death1.17675548
78MP0001501_abnormal_sleep_pattern1.17079798
79MP0003121_genomic_imprinting1.16846630
80MP0003786_premature_aging1.15436969
81MP0002138_abnormal_hepatobiliary_system1.15293785
82MP0004130_abnormal_muscle_cell1.10136998
83MP0006036_abnormal_mitochondrial_physio1.08865988
84MP0002557_abnormal_social/conspecific_i1.08635668
85MP0001486_abnormal_startle_reflex1.08027641
86MP0005195_abnormal_posterior_eye1.06182662
87MP0010386_abnormal_urinary_bladder1.04210558
88MP0001324_abnormal_eye_pigmentation1.04027170
89MP0002572_abnormal_emotion/affect_behav1.03985951
90MP0002735_abnormal_chemical_nociception1.03668451
91MP0003186_abnormal_redox_activity1.02389726
92MP0002733_abnormal_thermal_nociception1.01503069
93MP0003122_maternal_imprinting0.99194584
94MP0002080_prenatal_lethality0.98389641
95MP0001984_abnormal_olfaction0.97805017
96MP0002064_seizures0.96657649
97MP0001905_abnormal_dopamine_level0.96482942
98MP0001919_abnormal_reproductive_system0.95215573
99MP0000383_abnormal_hair_follicle0.95096490
100MP0002084_abnormal_developmental_patter0.95077924
101MP0003300_gastrointestinal_ulcer0.94885719
102MP0001970_abnormal_pain_threshold0.94250410
103MP0001293_anophthalmia0.94069099
104MP0000428_abnormal_craniofacial_morphol0.93650913
105MP0008932_abnormal_embryonic_tissue0.93605597
106MP0004197_abnormal_fetal_growth/weight/0.93522301
107MP0002751_abnormal_autonomic_nervous0.92703532
108MP0002019_abnormal_tumor_incidence0.92394854
109MP0000703_abnormal_thymus_morphology0.91555106
110MP0002132_abnormal_respiratory_system0.90187944
111MP0008789_abnormal_olfactory_epithelium0.89445103
112MP0004145_abnormal_muscle_electrophysio0.89407816
113MP0002752_abnormal_somatic_nervous0.88932457
114MP0000372_irregular_coat_pigmentation0.88899527
115MP0002277_abnormal_respiratory_mucosa0.87767933
116MP0001502_abnormal_circadian_rhythm0.87155187
117MP0006292_abnormal_olfactory_placode0.85971849
118MP0002085_abnormal_embryonic_tissue0.85963553
119MP0001727_abnormal_embryo_implantation0.85424015
120MP0002086_abnormal_extraembryonic_tissu0.84625397
121MP0000516_abnormal_urinary_system0.84519888
122MP0005367_renal/urinary_system_phenotyp0.84519888
123MP0008995_early_reproductive_senescence0.83738226
124MP0002067_abnormal_sensory_capabilities0.81702420
125MP0004742_abnormal_vestibular_system0.81354674
126MP0003137_abnormal_impulse_conducting0.81007701
127MP0002693_abnormal_pancreas_physiology0.79963738
128MP0004924_abnormal_behavior0.79587808
129MP0005386_behavior/neurological_phenoty0.79587808
130MP0002009_preneoplasia0.79498363
131MP0000689_abnormal_spleen_morphology0.77682740
132MP0008961_abnormal_basal_metabolism0.77230070
133MP0002722_abnormal_immune_system0.75678737
134MP0002398_abnormal_bone_marrow0.72496194
135MP0005379_endocrine/exocrine_gland_phen0.69583026
136MP0002095_abnormal_skin_pigmentation0.69415282
137MP0002234_abnormal_pharynx_morphology0.68701468
138MP0002405_respiratory_system_inflammati0.68585077
139MP0005384_cellular_phenotype0.67730283
140MP0009278_abnormal_bone_marrow0.64176011
141MP0003787_abnormal_imprinting0.63560433
142MP0005076_abnormal_cell_differentiation0.62247225
143MP0001119_abnormal_female_reproductive0.61769670
144MP0009703_decreased_birth_body0.61562690
145MP0004811_abnormal_neuron_physiology0.60648829
146MP0004947_skin_inflammation0.57993610
147MP0003718_maternal_effect0.56298558
148MP0002111_abnormal_tail_morphology0.53295741
149MP0002429_abnormal_blood_cell0.52764476
150MP0004885_abnormal_endolymph0.51639659
151MP0005389_reproductive_system_phenotype0.51572405
152MP0003115_abnormal_respiratory_system0.49831111
153MP0003632_abnormal_nervous_system0.49590092
154MP0003861_abnormal_nervous_system0.48698592
155MP0000716_abnormal_immune_system0.48682709
156MP0001915_intracranial_hemorrhage0.47357503
157MP0003119_abnormal_digestive_system0.46711855
158MP0001529_abnormal_vocalization0.46415857
159MP0002075_abnormal_coat/hair_pigmentati0.46163065
160MP0003045_fibrosis0.45490991
161MP0009672_abnormal_birth_weight0.45142670
162MP0005670_abnormal_white_adipose0.43889914
163MP0005621_abnormal_cell_physiology0.43032401
164MP0001790_abnormal_immune_system0.42491940
165MP0005387_immune_system_phenotype0.42491940
166MP0008872_abnormal_physiological_respon0.42429933
167MP0003699_abnormal_female_reproductive0.41356323
168MP0001986_abnormal_taste_sensitivity0.41067704

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.34568523
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.57028134
3Absent/shortened dynein arms (HP:0200106)7.57028134
4Hyperacusis (HP:0010780)7.41274635
5Overriding aorta (HP:0002623)7.22203124
6Elfin facies (HP:0004428)6.95415890
7Renovascular hypertension (HP:0100817)6.65398995
8Renal duplication (HP:0000075)6.20529423
9Abnormal respiratory epithelium morphology (HP:0012253)6.19184352
10Abnormal respiratory motile cilium morphology (HP:0005938)6.19184352
11Sensory axonal neuropathy (HP:0003390)6.10814667
12Abnormal respiratory motile cilium physiology (HP:0012261)6.08675369
13Toxemia of pregnancy (HP:0100603)6.05986198
14Insomnia (HP:0100785)5.81124021
15Rhinitis (HP:0012384)5.76157554
16Flat cornea (HP:0007720)5.73286699
17Chronic bronchitis (HP:0004469)5.38724696
18Polygenic inheritance (HP:0010982)4.93137599
19Nasal polyposis (HP:0100582)4.90515911
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.75448929
21Abnormal ciliary motility (HP:0012262)4.40564254
22Abnormality of the diencephalon (HP:0010662)4.30834139
23Abnormality of the nasal mucosa (HP:0000433)4.08341333
24Increased nuchal translucency (HP:0010880)4.04776343
25Bowel diverticulosis (HP:0005222)3.76144101
26Chronic otitis media (HP:0000389)3.75232470
27Pancreatic fibrosis (HP:0100732)3.67547716
28Congenital stationary night blindness (HP:0007642)3.66539844
29Bladder diverticulum (HP:0000015)3.63930376
30Hyporeflexia of lower limbs (HP:0002600)3.62025775
31Infertility (HP:0000789)3.59601908
32True hermaphroditism (HP:0010459)3.55455323
33Pendular nystagmus (HP:0012043)3.46459500
34Curly hair (HP:0002212)3.45892571
35Megalocornea (HP:0000485)3.38784188
36Bronchiectasis (HP:0002110)3.33081245
37Chronic sinusitis (HP:0011109)3.26916085
38Abnormality of the carotid arteries (HP:0005344)3.24954611
39Bronchitis (HP:0012387)3.19000545
40Acute necrotizing encephalopathy (HP:0006965)3.12484968
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09874256
42Abnormality of alanine metabolism (HP:0010916)3.09874256
43Hyperalaninemia (HP:0003348)3.09874256
44Abolished electroretinogram (ERG) (HP:0000550)3.03319221
45Type II lissencephaly (HP:0007260)2.94281002
46Male infertility (HP:0003251)2.94094254
47Areflexia of lower limbs (HP:0002522)2.91660048
48Abnormality of cochlea (HP:0000375)2.87239090
49Hypercalciuria (HP:0002150)2.85263604
50Mitochondrial inheritance (HP:0001427)2.82490967
51Acute encephalopathy (HP:0006846)2.81803535
52Colon cancer (HP:0003003)2.81182669
53Abnormal mitochondria in muscle tissue (HP:0008316)2.75907991
54Increased CSF lactate (HP:0002490)2.74130287
55Hypercalcemia (HP:0003072)2.65651064
56Progressive macrocephaly (HP:0004481)2.65195797
57Abnormality of the renal cortex (HP:0011035)2.59736713
58Nephronophthisis (HP:0000090)2.55006415
59Pointed chin (HP:0000307)2.54732338
60Abnormal spermatogenesis (HP:0008669)2.54618817
61Hepatocellular necrosis (HP:0001404)2.49656617
62Chorioretinal atrophy (HP:0000533)2.43799581
63Abnormal biliary tract physiology (HP:0012439)2.43770595
64Bile duct proliferation (HP:0001408)2.43770595
65Cystic liver disease (HP:0006706)2.40825423
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.36890956
67Abnormal rod and cone electroretinograms (HP:0008323)2.36260546
68Azoospermia (HP:0000027)2.34545326
69Patellar dislocation (HP:0002999)2.33861844
70Multifactorial inheritance (HP:0001426)2.33224916
71Abnormal number of erythroid precursors (HP:0012131)2.31793386
72Hepatic necrosis (HP:0002605)2.30126204
73Sclerocornea (HP:0000647)2.29710227
74Inability to walk (HP:0002540)2.29708708
75Keratoconus (HP:0000563)2.29656121
76Increased corneal curvature (HP:0100692)2.29656121
77Tubular atrophy (HP:0000092)2.29643666
78Methylmalonic acidemia (HP:0002912)2.28757110
79Renal cortical cysts (HP:0000803)2.28650981
80Recurrent otitis media (HP:0000403)2.27874594
81Aplasia/Hypoplasia of the patella (HP:0006498)2.27589701
823-Methylglutaconic aciduria (HP:0003535)2.22365069
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22278133
84Fibular aplasia (HP:0002990)2.22056278
85Hypoplasia of the pons (HP:0012110)2.20438585
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20045223
87Lipid accumulation in hepatocytes (HP:0006561)2.19990168
88Anencephaly (HP:0002323)2.18845889
89Aplasia/Hypoplasia of the uvula (HP:0010293)2.18649359
90Methylmalonic aciduria (HP:0012120)2.17851496
91Abnormality of the pons (HP:0007361)2.16279512
92Attenuation of retinal blood vessels (HP:0007843)2.14074238
93Abnormality of the gastric mucosa (HP:0004295)2.13345421
94Morphological abnormality of the pyramidal tract (HP:0002062)2.12955165
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.12823157
96Increased hepatocellular lipid droplets (HP:0006565)2.09940446
97Increased serum lactate (HP:0002151)2.09709141
98Short tibia (HP:0005736)2.09641845
99Hallux valgus (HP:0001822)2.09276788
100Abnormality of the ileum (HP:0001549)2.07662091
101Meckel diverticulum (HP:0002245)2.07478853
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07101829
103Hyperglycinemia (HP:0002154)2.06231093
104Obsessive-compulsive behavior (HP:0000722)2.04742907
105Recurrent sinusitis (HP:0011108)2.04578498
106Synostosis involving the elbow (HP:0003938)2.04169361
107Humeroradial synostosis (HP:0003041)2.04169361
108Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02951792
109Aplasia/hypoplasia of the uterus (HP:0008684)2.02694557
110Adactyly (HP:0009776)2.01502065
111Abnormality of the labia minora (HP:0012880)2.01261246
112Decreased central vision (HP:0007663)2.00987010
113Absent thumb (HP:0009777)2.00896097
114Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00870806
115Short 1st metacarpal (HP:0010034)2.00870806
116Optic disc pallor (HP:0000543)2.00300927
117Morphological abnormality of the inner ear (HP:0011390)1.99896005
118Large for gestational age (HP:0001520)1.98404000
119Abnormal drinking behavior (HP:0030082)1.97449780
120Polydipsia (HP:0001959)1.97449780
121Gait imbalance (HP:0002141)1.96875181
122Cerebellar dysplasia (HP:0007033)1.96871134
123Posterior embryotoxon (HP:0000627)1.96679437
124Optic nerve hypoplasia (HP:0000609)1.96379451
125Abnormality of cells of the erythroid lineage (HP:0012130)1.95986771
126Progressive inability to walk (HP:0002505)1.95168759
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.95151881
128Truncal ataxia (HP:0002078)1.94505616
129Lissencephaly (HP:0001339)1.94169977
130Fatigue (HP:0012378)1.94090228
131Congenital primary aphakia (HP:0007707)1.93437070
132Furrowed tongue (HP:0000221)1.93262325
133Chronic hepatic failure (HP:0100626)1.90859886
134Deviation of the hallux (HP:0010051)1.89795450
135Congenital, generalized hypertrichosis (HP:0004540)1.89494721
136Congenital hepatic fibrosis (HP:0002612)1.89257891
137Hypoplastic toenails (HP:0001800)1.88412689
138Heterotopia (HP:0002282)1.88327065
139Overlapping toe (HP:0001845)1.87801495
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87576031
141Patellar aplasia (HP:0006443)1.87531880
142Impulsivity (HP:0100710)1.87155740
143Cerebral edema (HP:0002181)1.86607535
144Abnormality of the line of Schwalbe (HP:0008048)1.85433404
145Arnold-Chiari malformation (HP:0002308)1.84045458
146Male pseudohermaphroditism (HP:0000037)1.84007437
147Birth length less than 3rd percentile (HP:0003561)1.83913923
148Bony spicule pigmentary retinopathy (HP:0007737)1.82961704
149Lactic acidosis (HP:0003128)1.82198397
150Reticulocytopenia (HP:0001896)1.81557962
151Abnormality of serum amino acid levels (HP:0003112)1.81134153
152Concave nail (HP:0001598)1.81053405
153Nephrogenic diabetes insipidus (HP:0009806)1.76520182
154Bilateral microphthalmos (HP:0007633)1.75509498
155Abnormality of the lower motor neuron (HP:0002366)1.74099596
156Periorbital edema (HP:0100539)1.73123429
157Recurrent bronchitis (HP:0002837)1.72517778
158Adducted thumb (HP:0001181)1.72285156
159Abnormality of the endocardium (HP:0004306)1.68567042
160Nephrocalcinosis (HP:0000121)1.65741599
161Cardiomegaly (HP:0001640)1.65360233
162Pancreatic cysts (HP:0001737)1.63685785
163Facial edema (HP:0000282)1.62276634
164Abnormality of the renal medulla (HP:0100957)1.60686611
165Precocious puberty (HP:0000826)1.58022893
166Oculomotor apraxia (HP:0000657)1.56820718
167Facial hemangioma (HP:0000329)1.56753280
168Sacral dimple (HP:0000960)1.56747269
169Tracheoesophageal fistula (HP:0002575)1.56211505
170Prenatal maternal abnormality (HP:0002686)1.53906926
171Spina bifida occulta (HP:0003298)1.52280621
172Spastic paraplegia (HP:0001258)1.47200093
173Medial flaring of the eyebrow (HP:0010747)1.44346904
174Polycystic kidney dysplasia (HP:0000113)1.43154344
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41471055
176Absent epiphyses (HP:0010577)1.41471055
177Bicuspid aortic valve (HP:0001647)1.37760114
178Ankyloglossia (HP:0010296)1.36835692
179Pes planus (HP:0001763)1.35067189
180Tongue fasciculations (HP:0001308)1.35022366
181Abnormality of midbrain morphology (HP:0002418)1.32446827
182Molar tooth sign on MRI (HP:0002419)1.32446827
183Radioulnar synostosis (HP:0002974)1.31848432
184Paraplegia (HP:0010550)1.30839007
185Recurrent urinary tract infections (HP:0000010)1.29238242
186Spastic tetraparesis (HP:0001285)1.26961953
187Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.26348604
188Polycystic ovaries (HP:0000147)1.26200811
189Polycythemia (HP:0001901)1.25597339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.36658268
2PDK37.36658268
3PDK24.68916062
4FRK4.24173404
5LMTK24.12711396
6MAP3K93.85703583
7TESK13.14952278
8ADRBK23.04153103
9YES12.63216534
10MAP4K22.61050737
11PRKD32.44561529
12WNK32.43368038
13NUAK12.43113804
14BUB12.32997534
15NEK22.32034311
16AKT32.01553599
17CDC71.83909343
18VRK21.82521045
19PINK11.80868024
20ICK1.80747817
21TYK21.79009022
22CASK1.63550809
23DYRK21.62137827
24ACVR1B1.60944282
25STK31.56995244
26INSRR1.55875873
27WEE11.51683511
28SRPK11.46134649
29OXSR11.45239079
30MAPK131.42685701
31PDGFRB1.37254251
32MKNK21.36045486
33GRK11.34920469
34MAP3K41.31174189
35CDK121.30785245
36TNIK1.28964174
37BCKDK1.27388360
38CCNB11.26068364
39TRIM281.26051269
40TAOK31.25333664
41TXK1.23983011
42NME11.20159526
43TTK1.17566445
44DAPK21.13820748
45TAF11.06570123
46NEK11.05728915
47PASK1.05241253
48PLK11.00346735
49TIE11.00119309
50CHEK20.99667855
51TSSK60.94070710
52CHEK10.90786290
53TLK10.90551636
54PRKCG0.90329677
55MKNK10.89514408
56ADRBK10.89343081
57HCK0.88236294
58MUSK0.84011833
59TESK20.82176099
60CSNK1G10.82144132
61CDK190.81544429
62ATR0.81436994
63CSNK1G20.80597292
64CDK70.79103389
65RPS6KA50.79012603
66ZAP700.78914787
67CSNK1G30.75371803
68STK380.74139518
69TAOK10.73860326
70PLK40.73637628
71PKN20.73038543
72MAPKAPK50.71446171
73STK160.70212342
74FGFR20.69245373
75PHKG20.68999870
76PHKG10.68999870
77PRKCE0.68923797
78BRAF0.68509337
79MTOR0.68384815
80STK40.68163321
81MAP4K10.67952264
82PRKG20.67600014
83AURKB0.67096413
84MAP2K70.65924842
85PTK2B0.64929184
86VRK10.64371534
87CDK40.63389910
88PLK20.63166157
89DYRK30.61797771
90TRIB30.61422606
91BMPR1B0.60079459
92ALK0.59945489
93MARK10.59765792
94BRSK20.59505946
95CSNK1A1L0.59252203
96BRD40.58394563
97PAK30.56897026
98MAP2K60.54712223
99PRKCQ0.54172316
100EPHA40.53787095
101IKBKB0.53448238
102STK38L0.50060165
103ZAK0.49788569
104CAMKK20.49571886
105MAP3K100.48893748
106CSNK1A10.48305293
107MST40.48194864
108SYK0.47978392
109TEC0.46302547
110CAMK10.44800263
111EIF2AK10.44740736
112PNCK0.42933298
113CAMK2A0.42419840
114PAK10.41630481
115BRSK10.41577032
116RIPK10.40998075
117PRKACA0.40911252
118CDK20.39970427
119PDK10.39941678
120FLT30.39899095
121BTK0.39590305
122ATM0.38036197
123EGFR0.36863665
124STK110.36120696
125MAP3K110.33457106
126CDK10.33030841
127PRKCI0.32548647
128PKN10.31644730
129OBSCN0.31575287
130CSNK1E0.31199675
131DYRK1B0.30960772
132BCR0.30908208
133AURKA0.30528746
134LRRK20.30420314
135EEF2K0.30059089
136WNK40.29661979
137PLK30.29526981
138STK100.28695695
139CSNK2A20.28520978
140STK390.27687880
141CSNK1D0.27182393
142PRKG10.27083587
143PIK3CA0.26733401
144PIM20.26606959
145KIT0.26581691
146SCYL20.26217585
147GRK60.25945071
148PBK0.24972951
149TYRO30.23916344
150MAPK100.20279289
151MAPK150.19947150
152MAP3K80.19874506
153PIM10.19098724
154CSF1R0.18659508
155LCK0.18381785
156PRKAA10.17757721
157MAPK70.17232860
158STK240.14739810
159ABL20.14231588
160TGFBR10.13345140
161MAP3K30.10385779
162MARK20.10079882
163CAMKK10.09879232
164CSNK2A10.09071799
165CDK60.08879395
166ABL10.08827117

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000305.19271959
2Homologous recombination_Homo sapiens_hsa034404.46070656
3Oxidative phosphorylation_Homo sapiens_hsa001903.08866645
4Mismatch repair_Homo sapiens_hsa034302.88206328
5RNA transport_Homo sapiens_hsa030132.80881400
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77912715
7DNA replication_Homo sapiens_hsa030302.71421642
8Fanconi anemia pathway_Homo sapiens_hsa034602.55319811
9Parkinsons disease_Homo sapiens_hsa050122.52335799
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48616461
11Base excision repair_Homo sapiens_hsa034102.39916808
12Basal transcription factors_Homo sapiens_hsa030222.27698883
13Biosynthesis of amino acids_Homo sapiens_hsa012302.18963157
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16857768
15Phototransduction_Homo sapiens_hsa047442.16477468
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.14323649
17Selenocompound metabolism_Homo sapiens_hsa004502.13570943
18Vitamin B6 metabolism_Homo sapiens_hsa007502.12947384
19Nitrogen metabolism_Homo sapiens_hsa009101.96520677
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91982270
21Systemic lupus erythematosus_Homo sapiens_hsa053221.85447698
22Proteasome_Homo sapiens_hsa030501.85179633
23Protein export_Homo sapiens_hsa030601.81840622
24Cell cycle_Homo sapiens_hsa041101.80076834
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.79324834
26Carbon metabolism_Homo sapiens_hsa012001.78561786
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76169381
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72063182
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67736089
30Nucleotide excision repair_Homo sapiens_hsa034201.66653593
31Butanoate metabolism_Homo sapiens_hsa006501.64541885
32Ether lipid metabolism_Homo sapiens_hsa005651.60542744
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60113038
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59461317
35Caffeine metabolism_Homo sapiens_hsa002321.58520203
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58039465
37Sulfur relay system_Homo sapiens_hsa041221.57646620
38Nicotine addiction_Homo sapiens_hsa050331.57415841
39Oocyte meiosis_Homo sapiens_hsa041141.57261992
40Alzheimers disease_Homo sapiens_hsa050101.55203163
41mRNA surveillance pathway_Homo sapiens_hsa030151.54640784
42Pyrimidine metabolism_Homo sapiens_hsa002401.44904115
43Pyruvate metabolism_Homo sapiens_hsa006201.44855298
44Spliceosome_Homo sapiens_hsa030401.43010511
45Antigen processing and presentation_Homo sapiens_hsa046121.38587916
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38094307
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33353383
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30820642
49Tryptophan metabolism_Homo sapiens_hsa003801.30035384
50Cardiac muscle contraction_Homo sapiens_hsa042601.29884180
51Propanoate metabolism_Homo sapiens_hsa006401.24470410
52One carbon pool by folate_Homo sapiens_hsa006701.22750660
53Dorso-ventral axis formation_Homo sapiens_hsa043201.22402171
54Legionellosis_Homo sapiens_hsa051341.22393513
55Fructose and mannose metabolism_Homo sapiens_hsa000511.19416405
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18879232
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18070569
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14335227
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13684089
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13637219
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13182403
62Glucagon signaling pathway_Homo sapiens_hsa049221.11126565
63Glycerolipid metabolism_Homo sapiens_hsa005611.10653376
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05831374
65Gastric acid secretion_Homo sapiens_hsa049711.05823698
66Taste transduction_Homo sapiens_hsa047421.05259980
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.03551452
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.03308046
69Peroxisome_Homo sapiens_hsa041461.00923718
70N-Glycan biosynthesis_Homo sapiens_hsa005101.00624938
71Viral carcinogenesis_Homo sapiens_hsa052030.99385665
72Ribosome_Homo sapiens_hsa030100.98838486
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98775941
74Purine metabolism_Homo sapiens_hsa002300.98468763
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97995797
76RNA polymerase_Homo sapiens_hsa030200.97101038
77Huntingtons disease_Homo sapiens_hsa050160.96714820
78Chronic myeloid leukemia_Homo sapiens_hsa052200.95699012
79p53 signaling pathway_Homo sapiens_hsa041150.94633481
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94555795
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.91624560
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91094699
83Alcoholism_Homo sapiens_hsa050340.89825289
84Olfactory transduction_Homo sapiens_hsa047400.89573214
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86378266
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85931205
87Retinol metabolism_Homo sapiens_hsa008300.85383037
88Chemical carcinogenesis_Homo sapiens_hsa052040.83354011
89Viral myocarditis_Homo sapiens_hsa054160.81828015
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81231312
91Arachidonic acid metabolism_Homo sapiens_hsa005900.81071619
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.79485231
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78219833
94Regulation of autophagy_Homo sapiens_hsa041400.78026935
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.76650211
96Linoleic acid metabolism_Homo sapiens_hsa005910.76339543
97Epstein-Barr virus infection_Homo sapiens_hsa051690.75967854
98Morphine addiction_Homo sapiens_hsa050320.75718367
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75540981
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72937805
101Vitamin digestion and absorption_Homo sapiens_hsa049770.71792004
102beta-Alanine metabolism_Homo sapiens_hsa004100.70487926
103Steroid biosynthesis_Homo sapiens_hsa001000.70091079
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69684987
105Fat digestion and absorption_Homo sapiens_hsa049750.68261005
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66966641
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66744912
108ErbB signaling pathway_Homo sapiens_hsa040120.66296585
109Herpes simplex infection_Homo sapiens_hsa051680.63347075
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62202732
111HTLV-I infection_Homo sapiens_hsa051660.60012875
112Sulfur metabolism_Homo sapiens_hsa009200.57537857
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53558648
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52379143
115Endocytosis_Homo sapiens_hsa041440.52171086
116Inositol phosphate metabolism_Homo sapiens_hsa005620.51490332
117RNA degradation_Homo sapiens_hsa030180.50803042
118Shigellosis_Homo sapiens_hsa051310.47141542
119Serotonergic synapse_Homo sapiens_hsa047260.47132634
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47034736
121Ovarian steroidogenesis_Homo sapiens_hsa049130.46795505
122Fatty acid elongation_Homo sapiens_hsa000620.46684090
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.46316329
124Insulin secretion_Homo sapiens_hsa049110.46304116
125Folate biosynthesis_Homo sapiens_hsa007900.45076663
126Fatty acid degradation_Homo sapiens_hsa000710.44674265
127Asthma_Homo sapiens_hsa053100.44536552
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42879079
129Glutamatergic synapse_Homo sapiens_hsa047240.42854007
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.42573101
131Amphetamine addiction_Homo sapiens_hsa050310.41621497
132GABAergic synapse_Homo sapiens_hsa047270.41126658
133Insulin signaling pathway_Homo sapiens_hsa049100.40201907
134Fatty acid biosynthesis_Homo sapiens_hsa000610.39454060
135Influenza A_Homo sapiens_hsa051640.38737095
136Non-homologous end-joining_Homo sapiens_hsa034500.37954262
137T cell receptor signaling pathway_Homo sapiens_hsa046600.37795186
138Glutathione metabolism_Homo sapiens_hsa004800.35333299
139Vibrio cholerae infection_Homo sapiens_hsa051100.34435351
140Primary immunodeficiency_Homo sapiens_hsa053400.33928624
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33447108
142AMPK signaling pathway_Homo sapiens_hsa041520.32712964
143Synaptic vesicle cycle_Homo sapiens_hsa047210.31616822
144Phenylalanine metabolism_Homo sapiens_hsa003600.30560052
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29872412
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29240361
147Collecting duct acid secretion_Homo sapiens_hsa049660.28528425
148Metabolic pathways_Homo sapiens_hsa011000.25007506
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.24609434
150Basal cell carcinoma_Homo sapiens_hsa052170.23294991
151B cell receptor signaling pathway_Homo sapiens_hsa046620.22631766
152HIF-1 signaling pathway_Homo sapiens_hsa040660.22322883
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22284141
154mTOR signaling pathway_Homo sapiens_hsa041500.21858883
155Colorectal cancer_Homo sapiens_hsa052100.20871760
156Long-term potentiation_Homo sapiens_hsa047200.20315225
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.19645207
158Hedgehog signaling pathway_Homo sapiens_hsa043400.18955282
159Measles_Homo sapiens_hsa051620.18036651
160Hippo signaling pathway_Homo sapiens_hsa043900.16508983
161VEGF signaling pathway_Homo sapiens_hsa043700.16450450
162Pathways in cancer_Homo sapiens_hsa052000.16394677
163Renal cell carcinoma_Homo sapiens_hsa052110.14791063
164ABC transporters_Homo sapiens_hsa020100.11937864

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