ZBTB33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)7.00953634
2nuclear pore complex assembly (GO:0051292)6.97122484
3cytoplasmic mRNA processing body assembly (GO:0033962)5.71064262
4pore complex assembly (GO:0046931)4.90364741
5protein localization to chromosome, centromeric region (GO:0071459)4.59949628
6DNA topological change (GO:0006265)4.39315704
7DNA unwinding involved in DNA replication (GO:0006268)4.18792095
8dosage compensation (GO:0007549)4.04758499
9mitotic chromosome condensation (GO:0007076)4.00183994
10positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90156575
11positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90156575
12positive regulation of mitotic sister chromatid separation (GO:1901970)3.90156575
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.90012607
14protein localization to kinetochore (GO:0034501)3.88511607
15sister chromatid segregation (GO:0000819)3.83868717
16alpha-linolenic acid metabolic process (GO:0036109)3.81709869
17regulation of DNA endoreduplication (GO:0032875)3.77459778
18mitotic nuclear envelope disassembly (GO:0007077)3.72500281
19regulation of NFAT protein import into nucleus (GO:0051532)3.70265469
20nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.62145377
21nuclear envelope disassembly (GO:0051081)3.60968854
22membrane disassembly (GO:0030397)3.60968854
23regulation of sister chromatid cohesion (GO:0007063)3.60484926
24histone H2B ubiquitination (GO:0033523)3.58601750
25attachment of spindle microtubules to kinetochore (GO:0008608)3.52140189
26protein localization to chromosome (GO:0034502)3.50163469
27positive regulation of cell size (GO:0045793)3.48958093
28positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.48663824
29mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.48663824
30dicarboxylic acid biosynthetic process (GO:0043650)3.45325343
31regulation of centriole replication (GO:0046599)3.44363038
32negative regulation of fibrinolysis (GO:0051918)3.43192826
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37398398
34urea metabolic process (GO:0019627)3.37067770
35urea cycle (GO:0000050)3.37067770
36olfactory bulb development (GO:0021772)3.32176271
37monoubiquitinated protein deubiquitination (GO:0035520)3.31759383
38regulation of fatty acid beta-oxidation (GO:0031998)3.29555838
39histone monoubiquitination (GO:0010390)3.24711473
40positive regulation of cell cycle checkpoint (GO:1901978)3.24484078
41DNA ligation (GO:0006266)3.24021863
42V(D)J recombination (GO:0033151)3.23662088
43negative regulation of DNA recombination (GO:0045910)3.23021343
44sister chromatid cohesion (GO:0007062)3.19741927
45mitotic sister chromatid segregation (GO:0000070)3.19549716
46protein K11-linked deubiquitination (GO:0035871)3.18470968
47regulation of histone H3-K9 methylation (GO:0051570)3.18346221
48positive regulation of histone deacetylation (GO:0031065)3.17110455
49nucleus organization (GO:0006997)3.14731146
50neural tube formation (GO:0001841)3.13930691
51lysine catabolic process (GO:0006554)3.12338123
52lysine metabolic process (GO:0006553)3.12338123
53positive regulation of chromosome segregation (GO:0051984)3.11657748
54microtubule depolymerization (GO:0007019)3.11493321
55non-recombinational repair (GO:0000726)3.11215173
56double-strand break repair via nonhomologous end joining (GO:0006303)3.11215173
57establishment of chromosome localization (GO:0051303)3.10759049
58midgut development (GO:0007494)3.08585347
59growth hormone receptor signaling pathway (GO:0060396)3.04167629
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.03590336
61L-phenylalanine catabolic process (GO:0006559)3.03590336
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.03311204
63mRNA splice site selection (GO:0006376)3.01139532
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00885881
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00885881
66mitotic metaphase plate congression (GO:0007080)2.99302086
67nuclear envelope organization (GO:0006998)2.98372570
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.98312062
693-UTR-mediated mRNA stabilization (GO:0070935)2.97417590
70spindle checkpoint (GO:0031577)2.97331242
71metaphase plate congression (GO:0051310)2.96749142
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.95999601
73mitotic spindle checkpoint (GO:0071174)2.95014748
74regulation of sister chromatid segregation (GO:0033045)2.94789614
75regulation of mitotic sister chromatid separation (GO:0010965)2.94789614
76regulation of mitotic sister chromatid segregation (GO:0033047)2.94789614
77bile acid biosynthetic process (GO:0006699)2.94024532
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.93932069
79NLS-bearing protein import into nucleus (GO:0006607)2.93479225
80histone ubiquitination (GO:0016574)2.93074910
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92201862
82germ cell migration (GO:0008354)2.92105497
83kynurenine metabolic process (GO:0070189)2.91532008
84histone lysine demethylation (GO:0070076)2.91381443
85regulation of fibrinolysis (GO:0051917)2.91356774
86mitotic sister chromatid cohesion (GO:0007064)2.90888316
87peptidyl-lysine dimethylation (GO:0018027)2.89991745
88complement activation, alternative pathway (GO:0006957)2.89908193
89regulation of cholesterol homeostasis (GO:2000188)2.88806835
90negative regulation of cholesterol transport (GO:0032375)2.88760786
91negative regulation of sterol transport (GO:0032372)2.88760786
92mRNA transport (GO:0051028)2.88598559
93regulation of protein activation cascade (GO:2000257)2.88368114
94spermatid nucleus differentiation (GO:0007289)2.86543202
95peptidyl-glutamic acid carboxylation (GO:0017187)2.85362087
96protein carboxylation (GO:0018214)2.85362087
97pre-miRNA processing (GO:0031054)2.84584520
98mitotic spindle organization (GO:0007052)2.84348540
99protein localization to endosome (GO:0036010)2.81638279
100nitrogen cycle metabolic process (GO:0071941)2.81169296
101COPI coating of Golgi vesicle (GO:0048205)2.80885152
102Golgi transport vesicle coating (GO:0048200)2.80885152
103regulation of chromosome segregation (GO:0051983)2.80658924
104layer formation in cerebral cortex (GO:0021819)2.79260222
105positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78780586
106mRNA export from nucleus (GO:0006406)2.78518119
107negative regulation of chromosome segregation (GO:0051985)2.76788993
108aromatic amino acid family catabolic process (GO:0009074)2.76470222
109poly(A)+ mRNA export from nucleus (GO:0016973)2.75677784
110RNA export from nucleus (GO:0006405)2.75382679
111microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.75156572
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75088792
113L-phenylalanine metabolic process (GO:0006558)2.75088792
114peptidyl-lysine trimethylation (GO:0018023)2.74488418
115DNA duplex unwinding (GO:0032508)2.74301542
116histone demethylation (GO:0016577)2.74132335
117mitotic spindle assembly checkpoint (GO:0007094)2.73134030
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72637978
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72637978
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72637978
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.72637978
122negative regulation of sister chromatid segregation (GO:0033046)2.72637978
123stress granule assembly (GO:0034063)2.72587791
124microtubule anchoring (GO:0034453)2.72358423
125negative regulation of cell killing (GO:0031342)2.72296250
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72296250
127regulation of complement activation (GO:0030449)2.72002047
128DNA geometric change (GO:0032392)2.71110639
129spindle assembly checkpoint (GO:0071173)2.70720314
130negative regulation of neurotransmitter secretion (GO:0046929)2.68629460
131glucocorticoid receptor signaling pathway (GO:0042921)2.68617471
132DNA double-strand break processing (GO:0000729)2.68568828
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68047687
134negative regulation of fibroblast apoptotic process (GO:2000270)2.67741588
135negative regulation of lipid transport (GO:0032369)2.66555353
136positive regulation of glycogen biosynthetic process (GO:0045725)2.60870997
137cysteine metabolic process (GO:0006534)2.60782661
138regulation of gamma-delta T cell differentiation (GO:0045586)2.60279635
139gastrulation with mouth forming second (GO:0001702)2.59419821
140cellular response to growth hormone stimulus (GO:0071378)2.56720289
141homocysteine metabolic process (GO:0050667)2.54755529
142high-density lipoprotein particle remodeling (GO:0034375)2.52772711
143glutamate metabolic process (GO:0006536)2.50556351
144sulfur amino acid catabolic process (GO:0000098)2.50322194
145glial cell proliferation (GO:0014009)2.47840221
146pyrimidine nucleobase catabolic process (GO:0006208)2.47011320
147indolalkylamine catabolic process (GO:0046218)2.45338341
148tryptophan catabolic process (GO:0006569)2.45338341
149indole-containing compound catabolic process (GO:0042436)2.45338341
150embryonic foregut morphogenesis (GO:0048617)2.45075644
151bile acid metabolic process (GO:0008206)2.44050349
152regulation of RNA export from nucleus (GO:0046831)2.43197941
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43188094
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.43188094
155vesicle coating (GO:0006901)2.40295317
156protein-lipid complex assembly (GO:0065005)2.40288187
157tryptophan metabolic process (GO:0006568)2.40249022
158glyoxylate metabolic process (GO:0046487)2.39275542
159fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39226172
160reverse cholesterol transport (GO:0043691)2.35517441
161corticosteroid receptor signaling pathway (GO:0031958)2.35280875
162nucleobase catabolic process (GO:0046113)2.34716031
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32993486
164positive regulation of lipid catabolic process (GO:0050996)2.32800407
165negative regulation of sodium ion transport (GO:0010766)2.31378664
166N-glycan processing (GO:0006491)2.30617684
167epoxygenase P450 pathway (GO:0019373)2.30536826
168complement activation, classical pathway (GO:0006958)2.30083573
169establishment of nucleus localization (GO:0040023)2.29668394
170cellular modified amino acid catabolic process (GO:0042219)2.29573759
171phospholipid homeostasis (GO:0055091)2.28384906
172negative regulation of histone methylation (GO:0031061)2.28046059
173positive regulation of nuclease activity (GO:0032075)2.27092510
174regulation of nucleobase-containing compound transport (GO:0032239)2.25588875
175histone H3-K9 demethylation (GO:0033169)2.25513599
176positive regulation of gamma-delta T cell activation (GO:0046645)2.24788717
177plasma lipoprotein particle assembly (GO:0034377)2.23792310
178hippo signaling (GO:0035329)2.23761061
179cellular ketone body metabolic process (GO:0046950)2.22438949
180negative regulation of fatty acid transport (GO:2000192)2.22130809
181COPII vesicle coating (GO:0048208)2.21042071
182regulation of gamma-delta T cell activation (GO:0046643)2.20965141
183cytolysis (GO:0019835)2.20636936
184histone H3-K36 demethylation (GO:0070544)2.20540552
185mRNA stabilization (GO:0048255)2.20009553
186RNA stabilization (GO:0043489)2.20009553
187positive regulation of glycogen metabolic process (GO:0070875)2.18419669
188regulation of polysaccharide biosynthetic process (GO:0032885)2.17438803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40759237
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.47259431
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.23177516
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88977671
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.58988637
6IGF1R_20145208_ChIP-Seq_DFB_Human3.30669577
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.20707539
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93680757
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91732025
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.85770898
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85084013
12CLOCK_20551151_ChIP-Seq_293T_Human2.79488231
13MYC_22102868_ChIP-Seq_BL_Human2.72154921
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68841853
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64034809
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54113650
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46878929
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44708700
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.39403480
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.31599942
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21602931
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.19913499
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10428787
24TAF15_26573619_Chip-Seq_HEK293_Human2.10361947
25* ELK1_19687146_ChIP-ChIP_HELA_Human2.08432915
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.08322299
27EWS_26573619_Chip-Seq_HEK293_Human2.04231823
28TCF7_22412390_ChIP-Seq_EML_Mouse1.99908045
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.98806787
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.94020232
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92993182
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90701667
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88974354
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87816339
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.87113249
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85748283
37KDM2B_26808549_Chip-Seq_DND41_Human1.85277843
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84841554
39FUS_26573619_Chip-Seq_HEK293_Human1.84439504
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82377092
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80735458
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.79731878
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76171696
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73882075
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67720383
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66458047
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.64975918
48ZNF263_19887448_ChIP-Seq_K562_Human1.63830186
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63130849
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62323640
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.61231745
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61120283
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58836458
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56796747
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54832317
56* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54003830
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50411339
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47872091
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42993234
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42376915
61VDR_23849224_ChIP-Seq_CD4+_Human1.42260194
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.42249921
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41665368
64TFEB_21752829_ChIP-Seq_HELA_Human1.41631133
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40989611
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.38920233
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37346286
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.36940697
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36427838
70RUNX_20019798_ChIP-Seq_JUKART_Human1.36334190
71KDM2B_26808549_Chip-Seq_K562_Human1.35725993
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34690344
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34020952
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32377262
75DCP1A_22483619_ChIP-Seq_HELA_Human1.29739986
76CIITA_25753668_ChIP-Seq_RAJI_Human1.28725750
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26690667
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25095047
79* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23767803
80* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23135858
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22694428
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22081914
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.21974976
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21000681
85TP53_16413492_ChIP-PET_HCT116_Human1.20682570
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20473131
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20384656
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18828805
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18683608
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17901488
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17783768
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.17398979
93UTX_26944678_Chip-Seq_JUKART_Human1.16385863
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15678744
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15151968
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15121356
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14832472
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14699379
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14431707
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13705037
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13399827
102MAF_26560356_Chip-Seq_TH1_Human1.12627382
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12576285
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11878704
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11673501
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11376842
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.09368099
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08912864
109MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08855578
110GATA1_22025678_ChIP-Seq_K562_Human1.08621939
111FOXP3_21729870_ChIP-Seq_TREG_Human1.08367583
112SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07733313
113CHD1_26751641_Chip-Seq_LNCaP_Human1.07265242
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06825336
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06357413
116* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06159201
117BRD4_25478319_ChIP-Seq_HGPS_Human1.05688177
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04959329
119ER_23166858_ChIP-Seq_MCF-7_Human1.04642862
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02793133
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02388173
122AR_21572438_ChIP-Seq_LNCaP_Human1.02313276
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.02229874
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01594385
125CREB1_26743006_Chip-Seq_LNCaP_Human1.00911746
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99972166
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99721981
128ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99195414
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.98034884
130REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97343085
131VDR_21846776_ChIP-Seq_THP-1_Human0.96777731
132* GATA6_25053715_ChIP-Seq_YYC3_Human0.96731987
133MYB_26560356_Chip-Seq_TH2_Human0.96646512
134KDM5A_27292631_Chip-Seq_BREAST_Human0.96199210
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96035077
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95903350
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95379275
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95044892
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94174355
140TTF2_22483619_ChIP-Seq_HELA_Human0.94063894
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92903109
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92611477
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92362680
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92219146
145HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91711111
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91588443
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91478314
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91166144
149AHR_22903824_ChIP-Seq_MCF-7_Human0.90812887
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.90798234
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90183665
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.90171884
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90078815
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.89854407
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89415023
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87583674
157* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87547960
158AR_21909140_ChIP-Seq_LNCAP_Human0.87140577
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86456376
160RXR_22108803_ChIP-Seq_LS180_Human0.86061795
161HNF4A_19822575_ChIP-Seq_HepG2_Human0.85981784
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85780000
163NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85413916
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.85174001
165XRN2_22483619_ChIP-Seq_HELA_Human0.83623988
166RNF2_27304074_Chip-Seq_NSC_Mouse0.83429678
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83162071
168EST1_17652178_ChIP-ChIP_JURKAT_Human0.82638482
169MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80926081
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80672905
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80249972
172SALL4_22934838_ChIP-ChIP_CD34+_Human0.80075142
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.78248974
174JUN_21703547_ChIP-Seq_K562_Human0.77706972
175NANOG_18555785_Chip-Seq_ESCs_Mouse0.77379101
176GABP_19822575_ChIP-Seq_HepG2_Human0.76475428
177SOX9_26525672_Chip-Seq_HEART_Mouse0.75915869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.52028990
2MP0002009_preneoplasia4.61743756
3MP0002139_abnormal_hepatobiliary_system4.41435542
4MP0010234_abnormal_vibrissa_follicle4.33385775
5MP0005360_urolithiasis4.15610497
6MP0003705_abnormal_hypodermis_morpholog4.07161828
7MP0010094_abnormal_chromosome_stability3.58753146
8MP0003300_gastrointestinal_ulcer3.53815065
9MP0005365_abnormal_bile_salt3.48569595
10MP0005085_abnormal_gallbladder_physiolo3.07401128
11MP0003252_abnormal_bile_duct3.01698637
12MP0010352_gastrointestinal_tract_polyps2.82621968
13MP0000569_abnormal_digit_pigmentation2.76324072
14MP0003221_abnormal_cardiomyocyte_apopto2.61500335
15MP0003077_abnormal_cell_cycle2.58483551
16MP0003111_abnormal_nucleus_morphology2.56411079
17MP0005076_abnormal_cell_differentiation2.53728187
18MP0008789_abnormal_olfactory_epithelium2.53557204
19MP0005394_taste/olfaction_phenotype2.43611188
20MP0005499_abnormal_olfactory_system2.43611188
21MP0008058_abnormal_DNA_repair2.43347983
22MP0004957_abnormal_blastocyst_morpholog2.33319907
23MP0003303_peritoneal_inflammation2.15962707
24MP0003693_abnormal_embryo_hatching2.15745961
25MP0008932_abnormal_embryonic_tissue2.10192440
26MP0009697_abnormal_copulation2.02991823
27MP0010329_abnormal_lipoprotein_level2.01843550
28MP0001666_abnormal_nutrient_absorption1.94580744
29MP0008877_abnormal_DNA_methylation1.90938113
30MP0008875_abnormal_xenobiotic_pharmacok1.90432218
31MP0003868_abnormal_feces_composition1.78142506
32MP0010678_abnormal_skin_adnexa1.72357330
33MP0002877_abnormal_melanocyte_morpholog1.70954640
34MP0008007_abnormal_cellular_replicative1.69723659
35MP0005187_abnormal_penis_morphology1.68435910
36MP0009780_abnormal_chondrocyte_physiolo1.66962170
37MP0009053_abnormal_anal_canal1.65900651
38MP0001849_ear_inflammation1.60232361
39MP0006054_spinal_hemorrhage1.58313327
40MP0010307_abnormal_tumor_latency1.55972520
41MP0000609_abnormal_liver_physiology1.54108589
42MP0003718_maternal_effect1.52008499
43MP0008961_abnormal_basal_metabolism1.51764758
44MP0000778_abnormal_nervous_system1.48983298
45MP0002254_reproductive_system_inflammat1.48555456
46MP0004185_abnormal_adipocyte_glucose1.47174993
47MP0003121_genomic_imprinting1.44904751
48MP0003656_abnormal_erythrocyte_physiolo1.44798414
49MP0005248_abnormal_Harderian_gland1.43715341
50MP0002166_altered_tumor_susceptibility1.42176794
51MP0000537_abnormal_urethra_morphology1.41045116
52MP0003890_abnormal_embryonic-extraembry1.34344452
53MP0001697_abnormal_embryo_size1.32738879
54MP0006292_abnormal_olfactory_placode1.32129624
55MP0002396_abnormal_hematopoietic_system1.31681030
56MP0002138_abnormal_hepatobiliary_system1.29460412
57MP0009384_cardiac_valve_regurgitation1.29437692
58MP0000647_abnormal_sebaceous_gland1.28749471
59MP0000733_abnormal_muscle_development1.27860904
60MP0005220_abnormal_exocrine_pancreas1.23686452
61MP0004264_abnormal_extraembryonic_tissu1.23524290
62MP0004782_abnormal_surfactant_physiolog1.22929826
63MP0002098_abnormal_vibrissa_morphology1.22920666
64MP0003091_abnormal_cell_migration1.20783620
65MP0002233_abnormal_nose_morphology1.18813484
66MP0005083_abnormal_biliary_tract1.17102960
67MP0001188_hyperpigmentation1.16871252
68MP0002080_prenatal_lethality1.16750204
69MP0001346_abnormal_lacrimal_gland1.11801233
70MP0008260_abnormal_autophagy1.09809803
71MP0003566_abnormal_cell_adhesion1.09636038
72MP0004197_abnormal_fetal_growth/weight/1.09411755
73MP0009672_abnormal_birth_weight1.08196639
74MP0004130_abnormal_muscle_cell1.07160865
75MP0001177_atelectasis1.06506638
76MP0004811_abnormal_neuron_physiology1.06165702
77MP0001727_abnormal_embryo_implantation1.04771149
78MP0005621_abnormal_cell_physiology1.04660262
79MP0003861_abnormal_nervous_system1.03634669
80MP0003880_abnormal_central_pattern1.03171477
81MP0002928_abnormal_bile_duct1.02853788
82MP0002085_abnormal_embryonic_tissue1.02789094
83MP0002796_impaired_skin_barrier1.02453114
84MP0009840_abnormal_foam_cell1.02017639
85MP0004947_skin_inflammation1.01641865
86MP0001286_abnormal_eye_development0.99780668
87MP0000566_synostosis0.99660466
88MP0001529_abnormal_vocalization0.99036255
89MP0003183_abnormal_peptide_metabolism0.97367067
90MP0000598_abnormal_liver_morphology0.96605541
91MP0001929_abnormal_gametogenesis0.96485907
92MP0002118_abnormal_lipid_homeostasis0.94340940
93MP0005384_cellular_phenotype0.93950459
94MP0001915_intracranial_hemorrhage0.93128347
95MP0002896_abnormal_bone_mineralization0.92865631
96MP0002909_abnormal_adrenal_gland0.92850941
97MP0003115_abnormal_respiratory_system0.91552317
98MP0000383_abnormal_hair_follicle0.91485754
99MP0000313_abnormal_cell_death0.91350056
100MP0009703_decreased_birth_body0.90572710
101MP0002086_abnormal_extraembryonic_tissu0.89247792
102MP0004808_abnormal_hematopoietic_stem0.88270347
103MP0003937_abnormal_limbs/digits/tail_de0.88230829
104MP0000604_amyloidosis0.88117713
105MP0003453_abnormal_keratinocyte_physiol0.87800488
106MP0005023_abnormal_wound_healing0.87733293
107MP0002234_abnormal_pharynx_morphology0.87547656
108MP0001984_abnormal_olfaction0.87007881
109MP0002092_abnormal_eye_morphology0.86858041
110MP0009278_abnormal_bone_marrow0.86326340
111MP0001293_anophthalmia0.85394492
112MP0003699_abnormal_female_reproductive0.84879404
113MP0003567_abnormal_fetal_cardiomyocyte0.83064198
114MP0005666_abnormal_adipose_tissue0.82094542
115MP0000428_abnormal_craniofacial_morphol0.81317713
116MP0003806_abnormal_nucleotide_metabolis0.80411691
117MP0002084_abnormal_developmental_patter0.80356503
118MP0002210_abnormal_sex_determination0.79008839
119MP0010368_abnormal_lymphatic_system0.78813672
120MP0002006_tumorigenesis0.78297989
121MP0003045_fibrosis0.76877619
122MP0005501_abnormal_skin_physiology0.76815034
123MP0003755_abnormal_palate_morphology0.76413225
124MP0008438_abnormal_cutaneous_collagen0.76001780
125MP0000653_abnormal_sex_gland0.75713620
126MP0003122_maternal_imprinting0.75143746
127MP0008995_early_reproductive_senescence0.75058681
128MP0000465_gastrointestinal_hemorrhage0.75053988
129MP0003191_abnormal_cellular_cholesterol0.74893531
130MP0002088_abnormal_embryonic_growth/wei0.74648353
131MP0000703_abnormal_thymus_morphology0.74305779
132MP0003787_abnormal_imprinting0.73703590
133MP0001881_abnormal_mammary_gland0.72042149
134MP0000003_abnormal_adipose_tissue0.71804831
135MP0001216_abnormal_epidermal_layer0.71765297
136MP0003943_abnormal_hepatobiliary_system0.71271642
137MP0002081_perinatal_lethality0.71197204
138MP0001944_abnormal_pancreas_morphology0.71014587
139MP0003984_embryonic_growth_retardation0.70764366
140MP0001191_abnormal_skin_condition0.70603796
141MP0002168_other_aberrant_phenotype0.70001953
142MP0001730_embryonic_growth_arrest0.69563176
143MP0005332_abnormal_amino_acid0.69507555
144MP0005375_adipose_tissue_phenotype0.67904156
145MP0000377_abnormal_hair_follicle0.67890754
146MP0000427_abnormal_hair_cycle0.65355689
147MP0002925_abnormal_cardiovascular_devel0.64172424
148MP0001672_abnormal_embryogenesis/_devel0.64070071
149MP0005380_embryogenesis_phenotype0.64070071
150MP0003935_abnormal_craniofacial_develop0.63596717
151MP0001299_abnormal_eye_distance/0.63381819
152MP0005319_abnormal_enzyme/_coenzyme0.63190496
153MP0005367_renal/urinary_system_phenotyp0.61771551
154MP0000516_abnormal_urinary_system0.61771551
155MP0001800_abnormal_humoral_immune0.60079373
156MP0008770_decreased_survivor_rate0.60044591
157MP0005623_abnormal_meninges_morphology0.59887137
158MP0005275_abnormal_skin_tensile0.59524992
159MP0000350_abnormal_cell_proliferation0.59442148
160MP0004859_abnormal_synaptic_plasticity0.58777837
161MP0002697_abnormal_eye_size0.58449065
162MP0004858_abnormal_nervous_system0.58077198
163MP0000685_abnormal_immune_system0.57534356

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.17128966
2Medulloblastoma (HP:0002885)3.93552898
3Thyroid carcinoma (HP:0002890)3.69266336
4Macroorchidism (HP:0000053)3.31675039
5Subacute progressive viral hepatitis (HP:0006572)3.06535075
6Nephroblastoma (Wilms tumor) (HP:0002667)2.97266896
7Deep philtrum (HP:0002002)2.91933138
8Cortical dysplasia (HP:0002539)2.83240696
9Intrahepatic cholestasis (HP:0001406)2.80399177
10Embryonal renal neoplasm (HP:0011794)2.76692678
11Complement deficiency (HP:0004431)2.73509765
12Uterine leiomyosarcoma (HP:0002891)2.69562369
13Leiomyosarcoma (HP:0100243)2.69562369
14Drooling (HP:0002307)2.69001965
15Urinary urgency (HP:0000012)2.68179229
16Chromsome breakage (HP:0040012)2.67101806
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66557825
18Degeneration of the lateral corticospinal tracts (HP:0002314)2.66557825
19Back pain (HP:0003418)2.63843152
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59659294
21Abnormality of chromosome stability (HP:0003220)2.59456949
22Rhabdomyosarcoma (HP:0002859)2.59278505
23Abnormality of the common coagulation pathway (HP:0010990)2.58261111
24Excessive salivation (HP:0003781)2.55965354
25Oligodactyly (hands) (HP:0001180)2.55946971
26Xanthomatosis (HP:0000991)2.55093837
27Autoamputation (HP:0001218)2.53570360
28Hypobetalipoproteinemia (HP:0003563)2.52188462
29Thickened helices (HP:0000391)2.50778501
30Curly hair (HP:0002212)2.48867629
31Mitral valve prolapse (HP:0001634)2.45217860
32Epidermoid cyst (HP:0200040)2.44921337
33Large earlobe (HP:0009748)2.44762841
34Spastic diplegia (HP:0001264)2.44572524
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43546114
36Insidious onset (HP:0003587)2.40941540
37Termporal pattern (HP:0011008)2.40941540
38Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.36927120
39Facial hemangioma (HP:0000329)2.36436062
40Ankyloglossia (HP:0010296)2.36042637
41Short 4th metacarpal (HP:0010044)2.33409806
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33409806
43Hyperacusis (HP:0010780)2.28849474
44Myocardial infarction (HP:0001658)2.28679418
45Abnormality of chromosome segregation (HP:0002916)2.27536466
46Abnormality of the corticospinal tract (HP:0002492)2.27392466
47Enlarged penis (HP:0000040)2.25024347
48Embryonal neoplasm (HP:0002898)2.23209727
49Aortic aneurysm (HP:0004942)2.19051086
50Oligodactyly (HP:0012165)2.18471132
51Shallow orbits (HP:0000586)2.17821681
52Hematochezia (HP:0002573)2.16902707
53Mitral stenosis (HP:0001718)2.16728777
54Cerebral aneurysm (HP:0004944)2.15990108
55Heterotopia (HP:0002282)2.15452291
56Abnormality of the 4th metacarpal (HP:0010012)2.15372548
57Lymphangioma (HP:0100764)2.13170174
58Abnormality of oral frenula (HP:0000190)2.11518467
59Renovascular hypertension (HP:0100817)2.11020551
60Disinhibition (HP:0000734)2.10697541
61Abnormality of the parathyroid morphology (HP:0011766)2.10240183
62Spinal cord lesions (HP:0100561)2.08705143
63Syringomyelia (HP:0003396)2.08705143
64Proximal placement of thumb (HP:0009623)2.07506264
65Cystic hygroma (HP:0000476)2.06159312
66Pelvic girdle muscle weakness (HP:0003749)2.06095649
67Shoulder girdle muscle weakness (HP:0003547)2.05914495
68Pseudobulbar signs (HP:0002200)2.05571559
69Neoplasm of striated muscle (HP:0009728)2.05166409
70Capillary hemangiomas (HP:0005306)2.05003375
71Hepatocellular carcinoma (HP:0001402)2.02820337
72Striae distensae (HP:0001065)2.01614475
73Scanning speech (HP:0002168)2.01518263
74Septate vagina (HP:0001153)2.00985430
75Truncal obesity (HP:0001956)2.00867717
76Abnormality of the lower motor neuron (HP:0002366)2.00688673
77Elfin facies (HP:0004428)1.99957376
78Hypochromic microcytic anemia (HP:0004840)1.99915923
79Renal cell carcinoma (HP:0005584)1.98622307
80Increased density of long bones (HP:0006392)1.98562252
81Congenital primary aphakia (HP:0007707)1.97678458
82Amyotrophic lateral sclerosis (HP:0007354)1.97170607
83Papilledema (HP:0001085)1.96737195
84Deviation of the thumb (HP:0009603)1.96694161
85Glioma (HP:0009733)1.95910370
8611 pairs of ribs (HP:0000878)1.94906333
87Exostoses (HP:0100777)1.94785975
88Aneurysm (HP:0002617)1.94384409
89Hallux valgus (HP:0001822)1.94127164
90Abnormality of the musculature of the pelvis (HP:0001469)1.93939073
91Abnormality of the hip-girdle musculature (HP:0001445)1.93939073
92Hyperlipoproteinemia (HP:0010980)1.93214171
93Impaired vibration sensation in the lower limbs (HP:0002166)1.92533260
94Gonadotropin excess (HP:0000837)1.92516521
95Rectal prolapse (HP:0002035)1.92365641
96Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91200302
97Nephrogenic diabetes insipidus (HP:0009806)1.90694336
98Dilatation of the ascending aorta (HP:0005111)1.89414068
99Abnormality of salivation (HP:0100755)1.89079421
100Volvulus (HP:0002580)1.88331480
101Hamartoma (HP:0010566)1.86909495
102Hypolipoproteinemia (HP:0010981)1.86598029
103Deviation of the hallux (HP:0010051)1.86577466
104Acute myeloid leukemia (HP:0004808)1.86392121
105Disproportionate tall stature (HP:0001519)1.86040748
106Neoplasm of the thyroid gland (HP:0100031)1.85973458
107Transitional cell carcinoma of the bladder (HP:0006740)1.85585482
108Obsessive-compulsive behavior (HP:0000722)1.84620882
109Abnormality of the fingertips (HP:0001211)1.84494384
110Breast carcinoma (HP:0003002)1.84481479
111Gait imbalance (HP:0002141)1.84317743
112Buphthalmos (HP:0000557)1.84167101
113Abnormality of complement system (HP:0005339)1.83425310
114Acanthocytosis (HP:0001927)1.83193753
115Broad alveolar ridges (HP:0000187)1.82480968
116Narrow palate (HP:0000189)1.82071366
117Esophageal varix (HP:0002040)1.81927521
118Papillary thyroid carcinoma (HP:0002895)1.79750798
119Sandal gap (HP:0001852)1.79412759
120Poor coordination (HP:0002370)1.77970238
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.76229729
122Low anterior hairline (HP:0000294)1.74245321
123Papilloma (HP:0012740)1.72920146
124Verrucae (HP:0200043)1.72920146
125Pheochromocytoma (HP:0002666)1.72626058
126Increased mean platelet volume (HP:0011877)1.72113426
127Asymmetry of the thorax (HP:0001555)1.71518716
128Combined immunodeficiency (HP:0005387)1.71020126
129Open mouth (HP:0000194)1.70474197
130Bladder neoplasm (HP:0009725)1.69987938
131Bladder carcinoma (HP:0002862)1.69987938
132Missing ribs (HP:0000921)1.69560422
133Viral hepatitis (HP:0006562)1.69240636
134Arterial tortuosity (HP:0005116)1.69140735
135Myelodysplasia (HP:0002863)1.69081622
136Vertebral arch anomaly (HP:0008438)1.68845449
137Long clavicles (HP:0000890)1.68239775
138Lower limb hyperreflexia (HP:0002395)1.68154419
139Abnormal lung lobation (HP:0002101)1.68114304
140Cafe-au-lait spot (HP:0000957)1.67366913
141Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67056683
142Bowel diverticulosis (HP:0005222)1.66978535
143Long toe (HP:0010511)1.66922689
144Abnormality of the Achilles tendon (HP:0005109)1.66717727
145Hepatitis (HP:0012115)1.66479569
146Fibrous tissue neoplasm (HP:0012316)1.66479154
147Hepatoblastoma (HP:0002884)1.65699397
148Absent frontal sinuses (HP:0002688)1.65572962
149Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65071607
150Hypoalphalipoproteinemia (HP:0003233)1.64236170
151Inappropriate behavior (HP:0000719)1.63858873
152B lymphocytopenia (HP:0010976)1.63754099
153Tubulointerstitial nephritis (HP:0001970)1.63637316
154Malignant gastrointestinal tract tumors (HP:0006749)1.63408748
155Gastrointestinal carcinoma (HP:0002672)1.63408748
156Bifid scrotum (HP:0000048)1.63024591
157Neoplasm of the oral cavity (HP:0100649)1.62262626
158Ulnar bowing (HP:0003031)1.62158837
159Abnormality of the antihelix (HP:0009738)1.61802551
160Nervous tissue neoplasm (HP:0030060)1.61703298
161Neuroectodermal neoplasm (HP:0030061)1.61703298
162Neuroepithelial neoplasm (HP:0030063)1.61703298
163Abnormality of sulfur amino acid metabolism (HP:0004339)1.61533359
164Cutis marmorata (HP:0000965)1.60897904
165Skin nodule (HP:0200036)1.60244970
166Cerebral inclusion bodies (HP:0100314)1.60183981
167Acute lymphatic leukemia (HP:0006721)1.60003761
168Fibroma (HP:0010614)1.59159566
169Protrusio acetabuli (HP:0003179)1.57995664
170T lymphocytopenia (HP:0005403)1.57894522
171Insomnia (HP:0100785)1.57793975
172Abnormal platelet volume (HP:0011876)1.54309960
173Persistence of primary teeth (HP:0006335)1.54307845
174Thin bony cortex (HP:0002753)1.53454712
175Biliary tract neoplasm (HP:0100574)1.52169521
176Overriding aorta (HP:0002623)1.51895385
177Increased nuchal translucency (HP:0010880)1.51697890
178Hypoglycemic coma (HP:0001325)1.51353329
179Increased CSF protein (HP:0002922)1.50822282
180Resting tremor (HP:0002322)1.50621545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.66506427
2BCR3.60530293
3SRPK13.50549932
4TRIB33.42693926
5MAP3K103.28975289
6EEF2K3.25390005
7BRSK23.20239561
8TRIM282.72956086
9MKNK12.61821477
10SCYL22.44772612
11PBK2.35387229
12LATS12.34056934
13PTK62.27252293
14FGFR22.24381966
15SIK12.18919364
16WEE12.16165020
17YES12.13125220
18EIF2AK32.00049192
19CDK121.97822083
20FRK1.97709851
21FGFR41.96549887
22TTK1.89113630
23PDGFRA1.85845806
24FGFR31.85155335
25SIK31.84512483
26CDK61.74248945
27CCNB11.69860122
28MKNK21.69659548
29RIPK11.62014110
30RET1.60803407
31CAMK1D1.60499993
32ERN11.56441458
33CAMK1G1.51615207
34DYRK31.46677149
35TAF11.38568342
36BRSK11.36761907
37EIF2AK11.36532906
38KSR21.35907477
39LRRK21.34944073
40PLK41.31276979
41TAOK31.29820165
42SIK21.29814685
43KSR11.27805010
44MAP3K91.26765930
45MAP3K21.26451728
46MARK11.26091605
47ALK1.20293992
48GRK61.16958379
49TYRO31.16900412
50CDK31.14789013
51PDGFRB1.14400199
52STK101.13884653
53UHMK11.12787745
54NEK61.12524785
55IRAK21.09312322
56MAP2K71.08124324
57FGFR11.07860575
58CAMKK21.07847588
59STK31.05661133
60MAP4K21.04441066
61TSSK61.03726529
62JAK11.02288315
63MAP3K71.01802380
64TTN1.01669705
65ATR0.98709810
66TAOK10.97400916
67MTOR0.95695830
68RAF10.95261758
69PRPF4B0.94803697
70SGK30.93721977
71MAP4K10.93528340
72PLK30.92977479
73MAP3K40.92031106
74CSNK1G20.90944675
75PRKCH0.90745306
76AKT30.85985596
77JAK20.84371188
78CAMKK10.82833216
79FLT30.81846736
80CSNK1A1L0.81095168
81PLK20.80534001
82ERBB30.80258326
83CHEK10.80245110
84BRD40.78623006
85TYK20.78465667
86PLK10.77236334
87MAP3K140.77138829
88CDK40.76489132
89EPHB10.74304239
90ICK0.73561035
91ATM0.72812492
92ITK0.72708292
93CASK0.71623266
94PTK20.69362273
95CHEK20.68862212
96NLK0.68439265
97PAK20.68410929
98CLK10.68357818
99EPHA30.68047935
100CDK90.65425306
101DYRK1B0.65008458
102CSNK1G10.64642380
103NEK20.64369639
104NTRK20.62082776
105PAK30.61901332
106RPS6KB10.61695941
107DDR20.61249944
108EIF2AK20.61232788
109PAK60.61163367
110TNIK0.61063171
111ERBB40.60966530
112BUB10.60932202
113CDK70.60866554
114CDK140.60678840
115IRAK10.60550368
116TGFBR20.60544900
117MAP2K40.59788686
118CSF1R0.59611399
119BMX0.58713955
120MELK0.57960206
121CDK180.57780940
122ERBB20.57318049
123EGFR0.56766274
124HIPK20.56069062
125CDK20.56038936
126AURKB0.55275086
127MAP3K80.55232988
128CDK10.54833335
129STK110.54705448
130PRKD30.53763859
131STK240.53640944
132RPS6KB20.53608107
133PNCK0.52876123
134DAPK20.51301120
135CSNK1D0.50752821
136LATS20.50207121
137BMPR20.50014260
138CSNK1G30.47686215
139HCK0.47033152
140PASK0.46662193
141CDK150.46399670
142RPS6KA40.45539028
143NUAK10.45421718
144PDK10.45416292
145SGK20.45239107
146NEK90.44247098
147FER0.43969385
148DMPK0.42690588
149MAPK130.42446846
150MAPK100.42118070
151JAK30.41161396
152GSK3A0.40864614
153BRAF0.40152383
154MAPK110.39949420
155MAP3K60.38831308
156SGK2230.38748840
157SGK4940.38748840
158MAP3K50.38584779
159CSNK1E0.37584977
160CDK11A0.37442287
161FYN0.37441072
162AURKA0.37055855
163CDC70.37043062
164DYRK1A0.37027373
165CAMK40.36458768
166CSK0.35472921
167NEK10.35315074
168PRKAA10.35251205
169CHUK0.35018248

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.18863300
2Non-homologous end-joining_Homo sapiens_hsa034503.54309612
3Cell cycle_Homo sapiens_hsa041103.12048577
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.82976772
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52922323
6mRNA surveillance pathway_Homo sapiens_hsa030152.37239835
7RNA transport_Homo sapiens_hsa030132.37103889
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27527759
9Spliceosome_Homo sapiens_hsa030402.14191242
10Arginine biosynthesis_Homo sapiens_hsa002202.05807450
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95070440
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.90787181
13Basal transcription factors_Homo sapiens_hsa030221.71399747
14Base excision repair_Homo sapiens_hsa034101.69816969
15Thyroid cancer_Homo sapiens_hsa052161.64271973
16Steroid biosynthesis_Homo sapiens_hsa001001.62890914
17Lysine degradation_Homo sapiens_hsa003101.58281129
18Complement and coagulation cascades_Homo sapiens_hsa046101.56692419
19DNA replication_Homo sapiens_hsa030301.56273499
20Mismatch repair_Homo sapiens_hsa034301.52905837
21Inositol phosphate metabolism_Homo sapiens_hsa005621.52446525
22Fanconi anemia pathway_Homo sapiens_hsa034601.48024925
23Oocyte meiosis_Homo sapiens_hsa041141.46394644
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44134067
25Chronic myeloid leukemia_Homo sapiens_hsa052201.43745979
26Tryptophan metabolism_Homo sapiens_hsa003801.43074569
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42382661
28mTOR signaling pathway_Homo sapiens_hsa041501.39393952
29Bile secretion_Homo sapiens_hsa049761.37129210
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36899148
31Caffeine metabolism_Homo sapiens_hsa002321.30948539
32Circadian rhythm_Homo sapiens_hsa047101.28584542
33RNA degradation_Homo sapiens_hsa030181.27987963
34Insulin resistance_Homo sapiens_hsa049311.25594174
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25295897
36p53 signaling pathway_Homo sapiens_hsa041151.20116642
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17466342
38Endometrial cancer_Homo sapiens_hsa052131.17193609
39Pancreatic cancer_Homo sapiens_hsa052121.16924007
40Fatty acid degradation_Homo sapiens_hsa000711.13153925
41Selenocompound metabolism_Homo sapiens_hsa004501.10999379
42Glioma_Homo sapiens_hsa052141.10454874
43Non-small cell lung cancer_Homo sapiens_hsa052231.09916493
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09249340
45Herpes simplex infection_Homo sapiens_hsa051681.08183874
46Nucleotide excision repair_Homo sapiens_hsa034201.05910297
47B cell receptor signaling pathway_Homo sapiens_hsa046621.04858731
48PPAR signaling pathway_Homo sapiens_hsa033201.04011769
49Type II diabetes mellitus_Homo sapiens_hsa049301.02784393
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02202979
51Adherens junction_Homo sapiens_hsa045201.00256757
52Butanoate metabolism_Homo sapiens_hsa006500.99783072
53Colorectal cancer_Homo sapiens_hsa052100.99297818
54MicroRNAs in cancer_Homo sapiens_hsa052060.95451906
55Proteoglycans in cancer_Homo sapiens_hsa052050.93959780
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93002705
57Staphylococcus aureus infection_Homo sapiens_hsa051500.92122525
58Epstein-Barr virus infection_Homo sapiens_hsa051690.90293122
59Dorso-ventral axis formation_Homo sapiens_hsa043200.88175003
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86511161
61Measles_Homo sapiens_hsa051620.85223205
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.85217795
63Prolactin signaling pathway_Homo sapiens_hsa049170.82974569
64Biosynthesis of amino acids_Homo sapiens_hsa012300.81800094
65Alcoholism_Homo sapiens_hsa050340.79951804
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79732981
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.79286506
68Small cell lung cancer_Homo sapiens_hsa052220.78586327
69Fatty acid metabolism_Homo sapiens_hsa012120.78118147
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77770359
71Vitamin B6 metabolism_Homo sapiens_hsa007500.77215542
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76533051
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76258003
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76077684
75Renal cell carcinoma_Homo sapiens_hsa052110.75816529
76Estrogen signaling pathway_Homo sapiens_hsa049150.75773210
77FoxO signaling pathway_Homo sapiens_hsa040680.75216303
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.75053762
79Influenza A_Homo sapiens_hsa051640.74776154
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74142480
81Focal adhesion_Homo sapiens_hsa045100.73783482
82Long-term depression_Homo sapiens_hsa047300.73083536
83T cell receptor signaling pathway_Homo sapiens_hsa046600.72950596
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.72606722
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72080498
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71559584
87Fat digestion and absorption_Homo sapiens_hsa049750.70520556
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70317174
89Insulin signaling pathway_Homo sapiens_hsa049100.70156010
90AMPK signaling pathway_Homo sapiens_hsa041520.69606569
91VEGF signaling pathway_Homo sapiens_hsa043700.69449158
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69315922
93Gap junction_Homo sapiens_hsa045400.68925709
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68232653
95Glucagon signaling pathway_Homo sapiens_hsa049220.67989251
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66566126
97Toxoplasmosis_Homo sapiens_hsa051450.66544197
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65668909
99Prostate cancer_Homo sapiens_hsa052150.65645650
100Prion diseases_Homo sapiens_hsa050200.64854295
101Bladder cancer_Homo sapiens_hsa052190.64003346
102Platelet activation_Homo sapiens_hsa046110.63347567
103Amoebiasis_Homo sapiens_hsa051460.62775157
104Regulation of autophagy_Homo sapiens_hsa041400.62770625
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61617649
106Osteoclast differentiation_Homo sapiens_hsa043800.60878479
107Viral myocarditis_Homo sapiens_hsa054160.60704920
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60304323
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59874922
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.59058855
111Hepatitis C_Homo sapiens_hsa051600.58405418
112Melanoma_Homo sapiens_hsa052180.57133981
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.56209311
114ErbB signaling pathway_Homo sapiens_hsa040120.55189208
115Long-term potentiation_Homo sapiens_hsa047200.54433399
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53596963
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53495604
118ABC transporters_Homo sapiens_hsa020100.53141880
119Hepatitis B_Homo sapiens_hsa051610.52635760
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52428618
121TGF-beta signaling pathway_Homo sapiens_hsa043500.52375177
122Acute myeloid leukemia_Homo sapiens_hsa052210.51767416
123Notch signaling pathway_Homo sapiens_hsa043300.50460772
124Legionellosis_Homo sapiens_hsa051340.50172832
125Homologous recombination_Homo sapiens_hsa034400.49766680
126Starch and sucrose metabolism_Homo sapiens_hsa005000.49312434
127HIF-1 signaling pathway_Homo sapiens_hsa040660.49309733
128Hippo signaling pathway_Homo sapiens_hsa043900.48196550
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48173359
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48047234
131Fatty acid biosynthesis_Homo sapiens_hsa000610.48033804
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.46853188
133beta-Alanine metabolism_Homo sapiens_hsa004100.46773059
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46411966
135Shigellosis_Homo sapiens_hsa051310.45109803
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44706812
137Thyroid hormone synthesis_Homo sapiens_hsa049180.44652150
138Propanoate metabolism_Homo sapiens_hsa006400.43829287
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43556661
140GnRH signaling pathway_Homo sapiens_hsa049120.43266298
141Apoptosis_Homo sapiens_hsa042100.42442288
142Viral carcinogenesis_Homo sapiens_hsa052030.42432943
143HTLV-I infection_Homo sapiens_hsa051660.42062989
144Rap1 signaling pathway_Homo sapiens_hsa040150.41154351
145Carbon metabolism_Homo sapiens_hsa012000.41064602
146Wnt signaling pathway_Homo sapiens_hsa043100.41029239
147Axon guidance_Homo sapiens_hsa043600.41024211
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40494822
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38779758
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38738278
151Chemokine signaling pathway_Homo sapiens_hsa040620.38407426
152Choline metabolism in cancer_Homo sapiens_hsa052310.37101728
153Hedgehog signaling pathway_Homo sapiens_hsa043400.36292340

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