ZBTB34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.68066996
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.64535785
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.64535785
4modulation by symbiont of host immune response (GO:0052553)5.64535785
5positive regulation by symbiont of host defense response (GO:0052509)5.64535785
6modulation by symbiont of host defense response (GO:0052031)5.64535785
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.64535785
8neutrophil activation involved in immune response (GO:0002283)5.22647478
9detection of molecule of bacterial origin (GO:0032490)5.08910768
10mitotic sister chromatid cohesion (GO:0007064)5.00452105
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.99239710
12cellular extravasation (GO:0045123)4.96118734
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88322411
14negative regulation of cell killing (GO:0031342)4.88322411
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72122691
16macrophage activation involved in immune response (GO:0002281)4.68197858
17response to peptidoglycan (GO:0032494)4.65088506
18detection of other organism (GO:0098543)4.60353707
19regulation of B cell receptor signaling pathway (GO:0050855)4.52801187
20leukocyte migration involved in inflammatory response (GO:0002523)4.34800977
21detection of external biotic stimulus (GO:0098581)4.31131856
22microglial cell activation (GO:0001774)4.28591618
23negative regulation of erythrocyte differentiation (GO:0045647)4.05477988
24detection of bacterium (GO:0016045)4.03597802
25response to host immune response (GO:0052572)3.99424767
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99424767
27neutrophil activation (GO:0042119)3.97927157
28nuclear pore organization (GO:0006999)3.95761212
29nuclear pore complex assembly (GO:0051292)3.94914897
30regulation of interferon-beta biosynthetic process (GO:0045357)3.92608075
31pre-miRNA processing (GO:0031054)3.89711853
32regulation of gamma-delta T cell activation (GO:0046643)3.86047143
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.84512152
34macrophage activation (GO:0042116)3.81602394
35detection of biotic stimulus (GO:0009595)3.81213276
36neutrophil mediated immunity (GO:0002446)3.80764457
37regulation of DNA endoreduplication (GO:0032875)3.77328722
38negative regulation of interleukin-12 production (GO:0032695)3.70415897
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69932132
40response to host (GO:0075136)3.69932132
41response to host defenses (GO:0052200)3.69932132
42respiratory burst (GO:0045730)3.65838167
43granulocyte activation (GO:0036230)3.57957971
44positive regulation of mast cell activation (GO:0033005)3.57138403
45regulation of mast cell degranulation (GO:0043304)3.53895181
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51473454
47B cell receptor signaling pathway (GO:0050853)3.48188758
48paraxial mesoderm development (GO:0048339)3.45868969
49leukocyte aggregation (GO:0070486)3.44427341
50positive regulation of cellular amide metabolic process (GO:0034250)3.40166814
51pore complex assembly (GO:0046931)3.37960603
52daunorubicin metabolic process (GO:0044597)3.36153774
53polyketide metabolic process (GO:0030638)3.36153774
54doxorubicin metabolic process (GO:0044598)3.36153774
55myeloid cell activation involved in immune response (GO:0002275)3.34873018
56regulation of gamma-delta T cell differentiation (GO:0045586)3.34551470
57regulation of mast cell activation involved in immune response (GO:0033006)3.34402753
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.34264150
59positive regulation of B cell differentiation (GO:0045579)3.34093219
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30659757
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30636043
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29488958
63negative regulation of translation, ncRNA-mediated (GO:0040033)3.28492352
64regulation of translation, ncRNA-mediated (GO:0045974)3.28492352
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28492352
66antigen processing and presentation of endogenous antigen (GO:0019883)3.28027439
67myeloid leukocyte mediated immunity (GO:0002444)3.26435427
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.26230854
69response to muramyl dipeptide (GO:0032495)3.25381022
70histone H3-K4 trimethylation (GO:0080182)3.23466487
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20495202
72regulation of leukocyte degranulation (GO:0043300)3.18327512
73kinetochore organization (GO:0051383)3.16672312
74regulation of RNA export from nucleus (GO:0046831)3.15953580
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14856004
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14856004
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.14856004
78regulation of mast cell activation (GO:0033003)3.13541664
79positive regulation of DNA-dependent DNA replication (GO:2000105)3.11725313
80kinetochore assembly (GO:0051382)3.10824194
81regulation of B cell differentiation (GO:0045577)3.10663638
82lateral sprouting from an epithelium (GO:0060601)3.06565555
83regulation of T-helper 2 cell differentiation (GO:0045628)3.05412990
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.03799007
85negative regulation of T-helper cell differentiation (GO:0045623)3.03741931
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03741931
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02859396
88histone H3-K4 methylation (GO:0051568)3.02467868
89response to interleukin-15 (GO:0070672)3.01317809
90production of molecular mediator involved in inflammatory response (GO:0002532)2.97783350
91negative regulation of T cell mediated immunity (GO:0002710)2.96726591
92regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.95193453
93positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.95193453
94histone H3-K36 demethylation (GO:0070544)2.94248448
95head development (GO:0060322)2.92049525
96germinal center formation (GO:0002467)2.91269836
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.89097524
98sister chromatid cohesion (GO:0007062)2.88607806
99G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.88426686
100cytoplasmic mRNA processing body assembly (GO:0033962)2.87680330
101negative regulation of leukocyte mediated immunity (GO:0002704)2.87622792
102DNA strand renaturation (GO:0000733)2.87239122
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84730482
104histone H4-K12 acetylation (GO:0043983)2.84700331
105sister chromatid segregation (GO:0000819)2.84156230
106histone H3-K9 methylation (GO:0051567)2.84120485
107positive T cell selection (GO:0043368)2.82969692
108positive regulation of mast cell activation involved in immune response (GO:0033008)2.81529166
109positive regulation of mast cell degranulation (GO:0043306)2.81529166
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80312803
111phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79788803
112regulation of regulated secretory pathway (GO:1903305)2.79005779
113regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.77769909
114positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.77769909
115regulation of erythrocyte differentiation (GO:0045646)2.76326140
116regulation of mitotic spindle checkpoint (GO:1903504)2.75612416
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75612416
118mitotic nuclear envelope disassembly (GO:0007077)2.74388973
119glucocorticoid receptor signaling pathway (GO:0042921)2.74309222
120negative regulation of histone methylation (GO:0031061)2.74286662
121meiotic chromosome segregation (GO:0045132)2.73604059
122neutrophil chemotaxis (GO:0030593)2.72400679
123mitotic metaphase plate congression (GO:0007080)2.71956739
124negative thymic T cell selection (GO:0045060)2.71738335
125mitotic sister chromatid segregation (GO:0000070)2.71098674
126positive regulation of interferon-alpha production (GO:0032727)2.71002144
127replication fork processing (GO:0031297)2.70860097
128histone H3-K9 modification (GO:0061647)2.70451615
129regulation of macrophage cytokine production (GO:0010935)2.70188688
130leukocyte degranulation (GO:0043299)2.69430542
131antigen processing and presentation via MHC class Ib (GO:0002475)2.69201172
132megakaryocyte development (GO:0035855)2.68460302
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68029235
134negative regulation of alpha-beta T cell activation (GO:0046636)2.67967453
135regulation of DNA damage checkpoint (GO:2000001)2.66230009
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65078822
137regulation of histone H3-K9 methylation (GO:0051570)2.65021779
138neutrophil migration (GO:1990266)2.65000023
139regulation of stem cell maintenance (GO:2000036)2.64351390
140dendritic cell migration (GO:0036336)2.62603900
141negative regulation of alpha-beta T cell differentiation (GO:0046639)2.62487926
142embryonic camera-type eye morphogenesis (GO:0048596)2.62368987
143interkinetic nuclear migration (GO:0022027)2.61160691
144regulation of platelet aggregation (GO:0090330)2.59816953
145protein localization to kinetochore (GO:0034501)2.59661565
146histone lysine methylation (GO:0034968)2.59450276
147positive regulation of chromosome segregation (GO:0051984)2.58918579
148regulation of MHC class II biosynthetic process (GO:0045346)2.58645914
149peptidyl-lysine trimethylation (GO:0018023)2.58276340
150RNA stabilization (GO:0043489)2.58193110
151mRNA stabilization (GO:0048255)2.58193110
152regulation of sister chromatid cohesion (GO:0007063)2.57767614
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56654362
154negative T cell selection (GO:0043383)2.55385131
155hematopoietic stem cell proliferation (GO:0071425)2.54889364
156positive regulation of toll-like receptor signaling pathway (GO:0034123)2.54827522
157regulation of telomere maintenance (GO:0032204)2.54056492
158nuclear envelope disassembly (GO:0051081)2.53870010
159membrane disassembly (GO:0030397)2.53870010
160regulation of DNA-dependent DNA replication (GO:0090329)2.52760616
161regulation of spindle organization (GO:0090224)2.51698159
162negative regulation of interleukin-17 production (GO:0032700)2.51663988
163dendritic cell chemotaxis (GO:0002407)2.51121546
164myeloid leukocyte activation (GO:0002274)2.50827227
165regulation of telomere maintenance via telomerase (GO:0032210)2.49959817
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49949431
167metaphase plate congression (GO:0051310)2.49865581
168regulation of interleukin-8 biosynthetic process (GO:0045414)2.49611803
169lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49538245
170regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49053221
171histone H4-K16 acetylation (GO:0043984)2.46128155
172histone mRNA catabolic process (GO:0071044)2.45713544
173negative regulation of granulocyte differentiation (GO:0030853)2.45069219
174histone methylation (GO:0016571)2.43631053
175regulation of chromatin silencing (GO:0031935)2.41583173
176positive regulation of SMAD protein import into nucleus (GO:0060391)2.39032874
177DNA geometric change (GO:0032392)2.38219184
178regulation of double-strand break repair (GO:2000779)2.36286426
179DNA double-strand break processing (GO:0000729)2.35660108
180regulation of nucleobase-containing compound transport (GO:0032239)2.35565683
181DNA duplex unwinding (GO:0032508)2.34806398
182replicative senescence (GO:0090399)2.34267766
183positive regulation of mRNA catabolic process (GO:0061014)2.34137368
184monoubiquitinated protein deubiquitination (GO:0035520)2.34064977
185corticosteroid receptor signaling pathway (GO:0031958)2.34010662
186dosage compensation (GO:0007549)2.33921441
187NLS-bearing protein import into nucleus (GO:0006607)2.33453582
188mRNA splice site selection (GO:0006376)2.31688780
189protein localization to chromosome, centromeric region (GO:0071459)2.29623591
190DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.29080691
191negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.29010329
192N-terminal protein amino acid acetylation (GO:0006474)2.28184707
193regulation of helicase activity (GO:0051095)2.26530513
194positive regulation of cell cycle checkpoint (GO:1901978)2.26494954
195DNA replication checkpoint (GO:0000076)2.25354982
196histone H4-K8 acetylation (GO:0043982)2.25106733
197histone H4-K5 acetylation (GO:0043981)2.25106733
198DNA demethylation (GO:0080111)2.24903216
199definitive hemopoiesis (GO:0060216)2.24612155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.95516032
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38957005
3TP63_19390658_ChIP-ChIP_HaCaT_Human4.23040519
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.78175231
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53383194
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.33423430
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29906064
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.20415804
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.18989849
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.16045200
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.06025685
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.97993857
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87417298
14GATA1_22025678_ChIP-Seq_K562_Human2.67702029
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56131887
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.55555242
17SPI1_23127762_ChIP-Seq_K562_Human2.53099464
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40940210
19VDR_24763502_ChIP-Seq_THP-1_Human2.37120331
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36732263
21RUNX_20019798_ChIP-Seq_JUKART_Human2.36489868
22VDR_24787735_ChIP-Seq_THP-1_Human2.23558019
23SPI1_23547873_ChIP-Seq_NB4_Human2.22957416
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.21795085
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20471420
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10735130
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10158581
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.99657056
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.99657056
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.99657056
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99480659
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94933970
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92612196
34MYB_26560356_Chip-Seq_TH2_Human1.91650330
35VDR_21846776_ChIP-Seq_THP-1_Human1.89755002
36* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88998676
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.87344912
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84939436
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77657593
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73350116
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72928339
42MYB_26560356_Chip-Seq_TH1_Human1.72166080
43GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70679022
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.70431968
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69324886
46SCL_19346495_ChIP-Seq_HPC-7_Human1.66992683
47PU_27001747_Chip-Seq_BMDM_Mouse1.63551810
48MAF_26560356_Chip-Seq_TH1_Human1.63013572
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61394095
50GATA1_19941826_ChIP-Seq_K562_Human1.58768583
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57799745
52EWS_26573619_Chip-Seq_HEK293_Human1.56619332
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56425597
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.52087297
55MYC_22102868_ChIP-Seq_BL_Human1.49537037
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.48850273
57GATA2_19941826_ChIP-Seq_K562_Human1.48612987
58KDM2B_26808549_Chip-Seq_DND41_Human1.47241401
59UTX_26944678_Chip-Seq_JUKART_Human1.43633755
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42405185
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42383052
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41078155
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.40378553
64FUS_26573619_Chip-Seq_HEK293_Human1.38945858
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38906937
66GATA3_27048872_Chip-Seq_THYMUS_Human1.38893057
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37917971
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37189227
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.35442413
70* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33944340
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.31720487
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31322695
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28771307
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.27214166
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25940211
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.24410444
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24132283
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23739016
79* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22773430
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20476097
81* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20397178
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20385956
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20193959
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20097427
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19807507
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19231319
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18876555
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17036917
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16417474
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15643276
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15209162
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14835507
93GBX2_23144817_ChIP-Seq_PC3_Human1.14753568
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14360408
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13720289
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13720289
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.13027144
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12840978
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12625992
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11455423
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10273233
102CIITA_25753668_ChIP-Seq_RAJI_Human1.09533907
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08871091
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07901711
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.06264644
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06014396
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04092552
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01839270
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98653989
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97636208
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97608653
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97227930
113* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96771335
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.96590979
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96150815
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95708517
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.95689550
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95545530
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95389040
120MAF_26560356_Chip-Seq_TH2_Human0.94163430
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92936376
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.91041116
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.90658312
124TCF7_22412390_ChIP-Seq_EML_Mouse0.90122913
125* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90084595
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.89907800
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89517118
128TP53_16413492_ChIP-PET_HCT116_Human0.89027381
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89016976
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88508469
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87928130
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87808850
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87707300
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87706672
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87344845
136RNF2_27304074_Chip-Seq_NSC_Mouse0.85597776
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.85208355
138* NCOR1_26117541_ChIP-Seq_K562_Human0.84946563
139MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84768723
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84341408
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84233314
142* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84065256
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83708576
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83262863
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83118424
146AR_21909140_ChIP-Seq_LNCAP_Human0.82761023
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.82514738
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82109005
149IGF1R_20145208_ChIP-Seq_DFB_Human0.82021220
150AR_21572438_ChIP-Seq_LNCaP_Human0.81778884
151RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81723742
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81623905
153KDM2B_26808549_Chip-Seq_K562_Human0.81046999
154BRD4_25478319_ChIP-Seq_HGPS_Human0.79906431
155FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.79507516
156SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79329402
157PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79076950
158NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77834434
159STAT3_23295773_ChIP-Seq_U87_Human0.77764596
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77236034
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76433679
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76385986
163* GATA3_26560356_Chip-Seq_TH2_Human0.76300612
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76274672
165GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75820935
166STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74644714
167POU5F1_16518401_ChIP-PET_MESCs_Mouse0.74379497
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73717844
169ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73010926
170CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72899775
171* SMRT_27268052_Chip-Seq_Bcells_Human0.72380484
172* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71044247
173ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70018939
174LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68332751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.77135193
2MP0003724_increased_susceptibility_to4.62402525
3MP0008057_abnormal_DNA_replication3.75768654
4MP0003436_decreased_susceptibility_to3.20451411
5MP0005464_abnormal_platelet_physiology3.17385497
6MP0008260_abnormal_autophagy2.79697376
7MP0010094_abnormal_chromosome_stability2.74452658
8MP0002396_abnormal_hematopoietic_system2.73971763
9MP0001835_abnormal_antigen_presentation2.73484330
10MP0006292_abnormal_olfactory_placode2.68934434
11MP0003111_abnormal_nucleus_morphology2.68289952
12MP0002419_abnormal_innate_immunity2.67821958
13MP0000569_abnormal_digit_pigmentation2.62766612
14MP0003300_gastrointestinal_ulcer2.44692414
15MP0000566_synostosis2.39919031
16MP0000465_gastrointestinal_hemorrhage2.31672305
17MP0003121_genomic_imprinting2.28497679
18MP0003693_abnormal_embryo_hatching2.22243251
19MP0001800_abnormal_humoral_immune2.20123009
20MP0003077_abnormal_cell_cycle2.15856807
21MP0005025_abnormal_response_to2.12509452
22MP0003172_abnormal_lysosome_physiology2.02239389
23MP0002132_abnormal_respiratory_system2.02200008
24MP0003787_abnormal_imprinting2.02041851
25MP0002723_abnormal_immune_serum1.98892901
26MP0002420_abnormal_adaptive_immunity1.98583806
27MP0005000_abnormal_immune_tolerance1.97548797
28MP0002452_abnormal_antigen_presenting1.96415796
29MP0001819_abnormal_immune_cell1.96129630
30MP0008058_abnormal_DNA_repair1.95810681
31MP0001293_anophthalmia1.93956370
32MP0004381_abnormal_hair_follicle1.93131081
33MP0003890_abnormal_embryonic-extraembry1.91485832
34MP0003191_abnormal_cellular_cholesterol1.91266422
35MP0004947_skin_inflammation1.88694468
36MP0003183_abnormal_peptide_metabolism1.86926168
37MP0002398_abnormal_bone_marrow1.86266413
38MP0008877_abnormal_DNA_methylation1.86192480
39MP0005451_abnormal_body_composition1.81701692
40MP0009785_altered_susceptibility_to1.72645355
41MP0000685_abnormal_immune_system1.71362722
42MP0003221_abnormal_cardiomyocyte_apopto1.70961967
43MP0002405_respiratory_system_inflammati1.70454448
44MP0005387_immune_system_phenotype1.68291863
45MP0001790_abnormal_immune_system1.68291863
46MP0005367_renal/urinary_system_phenotyp1.65498550
47MP0000516_abnormal_urinary_system1.65498550
48MP0003656_abnormal_erythrocyte_physiolo1.65289964
49MP0005671_abnormal_response_to1.64604368
50MP0005409_darkened_coat_color1.64014949
51MP0002938_white_spotting1.60417043
52MP0004808_abnormal_hematopoietic_stem1.60084206
53MP0005076_abnormal_cell_differentiation1.59944450
54MP0003122_maternal_imprinting1.59266691
55MP0000716_abnormal_immune_system1.58510650
56MP0003763_abnormal_thymus_physiology1.54747870
57MP0008007_abnormal_cellular_replicative1.53457721
58MP0000689_abnormal_spleen_morphology1.52950887
59MP0010030_abnormal_orbit_morphology1.52384839
60MP0002722_abnormal_immune_system1.52160345
61MP0008004_abnormal_stomach_pH1.50323635
62MP0001533_abnormal_skeleton_physiology1.48634471
63MP0003941_abnormal_skin_development1.48562052
64MP0001672_abnormal_embryogenesis/_devel1.46980772
65MP0005380_embryogenesis_phenotype1.46980772
66MP0009053_abnormal_anal_canal1.46629918
67MP0010352_gastrointestinal_tract_polyps1.44688864
68MP0000350_abnormal_cell_proliferation1.43035048
69MP0009278_abnormal_bone_marrow1.42779111
70MP0004883_abnormal_blood_vessel1.40164433
71MP0003935_abnormal_craniofacial_develop1.38921258
72MP0004957_abnormal_blastocyst_morpholog1.38754776
73MP0003984_embryonic_growth_retardation1.38735806
74MP0002085_abnormal_embryonic_tissue1.37620447
75MP0010307_abnormal_tumor_latency1.37420940
76MP0001851_eye_inflammation1.36831795
77MP0002277_abnormal_respiratory_mucosa1.36803413
78MP0002088_abnormal_embryonic_growth/wei1.36590701
79MP0003755_abnormal_palate_morphology1.36400134
80MP0002084_abnormal_developmental_patter1.35827064
81MP0005248_abnormal_Harderian_gland1.35061375
82MP0000490_abnormal_crypts_of1.33491970
83MP0004197_abnormal_fetal_growth/weight/1.33279919
84MP0006082_CNS_inflammation1.32646919
85MP0002429_abnormal_blood_cell1.32373859
86MP0005257_abnormal_intraocular_pressure1.31788522
87MP0009703_decreased_birth_body1.30720074
88MP0002148_abnormal_hypersensitivity_rea1.30367673
89MP0000432_abnormal_head_morphology1.29775097
90MP0003937_abnormal_limbs/digits/tail_de1.27694078
91MP0003123_paternal_imprinting1.25321158
92MP0003567_abnormal_fetal_cardiomyocyte1.23681554
93MP0004510_myositis1.23643196
94MP0001188_hyperpigmentation1.23095813
95MP0002086_abnormal_extraembryonic_tissu1.23021301
96MP0001845_abnormal_inflammatory_respons1.22211620
97MP0002998_abnormal_bone_remodeling1.19727313
98MP0000858_altered_metastatic_potential1.19467731
99MP0000428_abnormal_craniofacial_morphol1.17108559
100MP0003938_abnormal_ear_development1.16767596
101MP0005397_hematopoietic_system_phenotyp1.15857929
102MP0001545_abnormal_hematopoietic_system1.15857929
103MP0005310_abnormal_salivary_gland1.13629764
104MP0002249_abnormal_larynx_morphology1.13422503
105MP0002116_abnormal_craniofacial_bone1.13278873
106MP0004264_abnormal_extraembryonic_tissu1.13251164
107MP0003385_abnormal_body_wall1.12818579
108MP0005174_abnormal_tail_pigmentation1.12389126
109MP0003690_abnormal_glial_cell1.11848544
110MP0003866_abnormal_defecation1.07987315
111MP0002075_abnormal_coat/hair_pigmentati1.07334844
112MP0003119_abnormal_digestive_system1.06673499
113MP0001286_abnormal_eye_development1.05219399
114MP0010155_abnormal_intestine_physiology1.05207646
115MP0003448_altered_tumor_morphology1.04397375
116MP0000049_abnormal_middle_ear1.03209226
117MP0003091_abnormal_cell_migration1.03091396
118MP0001697_abnormal_embryo_size1.02030858
119MP0002233_abnormal_nose_morphology1.01217247
120MP0002925_abnormal_cardiovascular_devel1.00463990
121MP0009250_abnormal_appendicular_skeleto1.00458966
122MP0003705_abnormal_hypodermis_morpholog0.99998842
123MP0002932_abnormal_joint_morphology0.99126070
124MP0003828_pulmonary_edema0.98232625
125MP0002009_preneoplasia0.97752668
126MP0002109_abnormal_limb_morphology0.96980023
127MP0002092_abnormal_eye_morphology0.96727114
128MP0009672_abnormal_birth_weight0.91586655
129MP0002653_abnormal_ependyma_morphology0.89531405
130MP0004130_abnormal_muscle_cell0.88874189
131MP0003861_abnormal_nervous_system0.88349231
132MP0002166_altered_tumor_susceptibility0.88323793
133MP0001730_embryonic_growth_arrest0.87939037
134MP0004484_altered_response_of0.87625671
135MP0000703_abnormal_thymus_morphology0.86943019
136MP0002697_abnormal_eye_size0.86791338
137MP0002102_abnormal_ear_morphology0.86677084
138MP0000383_abnormal_hair_follicle0.85518896
139MP0003453_abnormal_keratinocyte_physiol0.84912121
140MP0005164_abnormal_response_to0.84542301
141MP0002114_abnormal_axial_skeleton0.81458162
142MP0001346_abnormal_lacrimal_gland0.81305680
143MP0003942_abnormal_urinary_system0.81090228
144MP0000733_abnormal_muscle_development0.80939498
145MP0002111_abnormal_tail_morphology0.79919578
146MP0003943_abnormal_hepatobiliary_system0.79536486
147MP0003566_abnormal_cell_adhesion0.79425845
148MP0005075_abnormal_melanosome_morpholog0.78633465
149MP0000313_abnormal_cell_death0.78116355
150MP0000015_abnormal_ear_pigmentation0.77859622
151MP0005171_absent_coat_pigmentation0.77574428
152MP0002133_abnormal_respiratory_system0.77087991
153MP0005388_respiratory_system_phenotype0.77087991
154MP0002080_prenatal_lethality0.77007946
155MP0002163_abnormal_gland_morphology0.76257510
156MP0001186_pigmentation_phenotype0.75701023
157MP0001915_intracranial_hemorrhage0.74091645
158MP0009764_decreased_sensitivity_to0.73441989
159MP0002210_abnormal_sex_determination0.73295399
160MP0001119_abnormal_female_reproductive0.73141858
161MP0005058_abnormal_lysosome_morphology0.73007487
162MP0009765_abnormal_xenobiotic_induced0.72553172
163MP0009763_increased_sensitivity_to0.71346402
164MP0008469_abnormal_protein_level0.71309501
165MP0000631_abnormal_neuroendocrine_gland0.70627159
166MP0000762_abnormal_tongue_morphology0.70516676
167MP0008932_abnormal_embryonic_tissue0.69948920
168MP0002095_abnormal_skin_pigmentation0.69412205
169MP0000371_diluted_coat_color0.67563375
170MP0002332_abnormal_exercise_endurance0.62319064
171MP0009333_abnormal_splenocyte_physiolog0.61938750
172MP0001663_abnormal_digestive_system0.61736387
173MP0005621_abnormal_cell_physiology0.60267147
174MP0006054_spinal_hemorrhage0.60077957
175MP0004185_abnormal_adipocyte_glucose0.58899249

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.55833445
2Recurrent bacterial skin infections (HP:0005406)4.98292378
3Recurrent abscess formation (HP:0002722)4.81848968
4Abnormality of macrophages (HP:0004311)4.31910954
5Spontaneous hematomas (HP:0007420)4.25504351
6Prolonged bleeding time (HP:0003010)4.24867828
7Orchitis (HP:0100796)3.75945835
8Myositis (HP:0100614)3.75232354
9Optic neuritis (HP:0100653)3.74546157
10Retrobulbar optic neuritis (HP:0100654)3.74546157
11Recurrent gram-negative bacterial infections (HP:0005420)3.67549205
12Short 4th metacarpal (HP:0010044)3.44495576
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.44495576
14Abnormal platelet volume (HP:0011876)3.42137283
15Volvulus (HP:0002580)3.40366156
16Chromsome breakage (HP:0040012)3.31194438
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31086183
18Gingival bleeding (HP:0000225)3.28010534
19Epistaxis (HP:0000421)3.27138220
20Gingivitis (HP:0000230)3.15580293
21Gastrointestinal infarctions (HP:0005244)3.04852507
22Recurrent fungal infections (HP:0002841)3.00698174
23Recurrent skin infections (HP:0001581)2.98751884
24Stomatitis (HP:0010280)2.98359386
25Increased mean platelet volume (HP:0011877)2.96032203
26Keratoconjunctivitis sicca (HP:0001097)2.93085794
27Abnormality of the fingertips (HP:0001211)2.92119425
28Ectopic kidney (HP:0000086)2.88519495
29Petechiae (HP:0000967)2.86609784
30Long eyelashes (HP:0000527)2.79720773
31Mediastinal lymphadenopathy (HP:0100721)2.72791844
32Abnormality of the nasal septum (HP:0000419)2.72443173
33Curly hair (HP:0002212)2.72018994
34Chest pain (HP:0100749)2.64480480
35Urethral obstruction (HP:0000796)2.61998502
36Meningitis (HP:0001287)2.59751999
37Obstructive lung disease (HP:0006536)2.59550091
38Chronic obstructive pulmonary disease (HP:0006510)2.59550091
39Keratoconjunctivitis (HP:0001096)2.59196985
40T lymphocytopenia (HP:0005403)2.56654373
41Cellulitis (HP:0100658)2.54143760
42Subacute progressive viral hepatitis (HP:0006572)2.49852549
43Intestinal fistula (HP:0100819)2.48453898
44Supernumerary ribs (HP:0005815)2.45643197
45Arterial thrombosis (HP:0004420)2.45381291
46Neoplasm of the oral cavity (HP:0100649)2.45120100
47Osteomyelitis (HP:0002754)2.42003825
48Menorrhagia (HP:0000132)2.40818658
49Abnormality of the parietal bone (HP:0002696)2.40414633
50Lip pit (HP:0100267)2.40202625
51Encephalitis (HP:0002383)2.39414465
52Chronic mucocutaneous candidiasis (HP:0002728)2.39343042
53Recurrent cutaneous fungal infections (HP:0011370)2.39343042
54Peritonitis (HP:0002586)2.39253410
55Medulloblastoma (HP:0002885)2.38371265
56Elevated erythrocyte sedimentation rate (HP:0003565)2.37328397
57Increased IgE level (HP:0003212)2.36655334
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.34236014
59Midline defect of the nose (HP:0004122)2.33765792
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33623027
61Difficulty running (HP:0009046)2.33488480
62Abnormality of T cell number (HP:0011839)2.32975357
63Increased number of teeth (HP:0011069)2.32724012
64Trigonocephaly (HP:0000243)2.31456361
65Urticaria (HP:0001025)2.28704224
66Increased nuchal translucency (HP:0010880)2.26549818
67Vasculitis (HP:0002633)2.24879561
68Abnormality of the labia minora (HP:0012880)2.23748067
69Abnormal platelet function (HP:0011869)2.20839503
70Impaired platelet aggregation (HP:0003540)2.20839503
71Supernumerary bones of the axial skeleton (HP:0009144)2.19363879
72Rib fusion (HP:0000902)2.19142627
73Leukocytosis (HP:0001974)2.19090543
74Abnormality of the 4th metacarpal (HP:0010012)2.18167076
75Aplasia cutis congenita (HP:0001057)2.17907049
76Slow saccadic eye movements (HP:0000514)2.17487124
77Episodic fever (HP:0001954)2.15325638
78Hemoptysis (HP:0002105)2.15009683
79Deep philtrum (HP:0002002)2.14907242
80Acanthocytosis (HP:0001927)2.11327091
81Abnormal number of incisors (HP:0011064)2.10885118
82Prominent nose (HP:0000448)2.10662683
83Polycythemia (HP:0001901)2.09669896
84Abnormality of the columella (HP:0009929)2.09241052
85Rectovaginal fistula (HP:0000143)2.07332160
86Rectal fistula (HP:0100590)2.07332160
87Back pain (HP:0003418)2.06395258
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.05312365
89Facial hemangioma (HP:0000329)2.04766794
90Recurrent viral infections (HP:0004429)2.04560040
91Abnormality of the incisor (HP:0000676)2.04328911
92Hypoplasia of the maxilla (HP:0000327)2.03829396
93Abnormality of the ileum (HP:0001549)2.03673171
94Meckel diverticulum (HP:0002245)2.03156106
95Bilateral sensorineural hearing impairment (HP:0008619)2.03103156
96Viral hepatitis (HP:0006562)2.02954546
97Pulmonary embolism (HP:0002204)2.02072334
98Purpura (HP:0000979)2.00391043
99Abnormality of the carotid arteries (HP:0005344)1.99934993
100Syringomyelia (HP:0003396)1.99473572
101Spinal cord lesions (HP:0100561)1.99473572
102Renal duplication (HP:0000075)1.98724962
103Absent eyebrow (HP:0002223)1.97407273
104Narrow palate (HP:0000189)1.96929864
105Microcytic anemia (HP:0001935)1.95114637
106Acute myeloid leukemia (HP:0004808)1.94527200
107Thickened calvaria (HP:0002684)1.94252588
108Oligodontia (HP:0000677)1.88781875
109Thyroid carcinoma (HP:0002890)1.88263515
110Bladder neoplasm (HP:0009725)1.87421693
111Bladder carcinoma (HP:0002862)1.87421693
112Prostate neoplasm (HP:0100787)1.86411418
113Amaurosis fugax (HP:0100576)1.86267807
114Hypochromic anemia (HP:0001931)1.85882305
115Abnormality of chromosome stability (HP:0003220)1.84881809
116Neonatal hypoglycemia (HP:0001998)1.82982289
117Patellar aplasia (HP:0006443)1.81792527
118Broad thumb (HP:0011304)1.81038432
119Poikilocytosis (HP:0004447)1.79871933
120Agnosia (HP:0010524)1.79275098
121Breast hypoplasia (HP:0003187)1.79247474
122Cheilitis (HP:0100825)1.79034286
123Pulmonary infiltrates (HP:0002113)1.78811480
124Anal stenosis (HP:0002025)1.78645406
125Sepsis (HP:0100806)1.78223544
126Birth length less than 3rd percentile (HP:0003561)1.77453972
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76382991
128Astrocytoma (HP:0009592)1.75914651
129Abnormality of the astrocytes (HP:0100707)1.75914651
130Hypoplastic labia majora (HP:0000059)1.75510359
131Impulsivity (HP:0100710)1.74537420
132Inflammation of the large intestine (HP:0002037)1.74474781
133Glioma (HP:0009733)1.74430708
134Abnormality of the diencephalon (HP:0010662)1.74366898
135Smooth philtrum (HP:0000319)1.74053547
136Abnormality of the preputium (HP:0100587)1.72882246
137Myelodysplasia (HP:0002863)1.72818999
138Skull defect (HP:0001362)1.72758137
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71511464
140Abnormality of the endocardium (HP:0004306)1.71264823
141Dislocated radial head (HP:0003083)1.70800364
142Gastrointestinal inflammation (HP:0004386)1.69943894
143Conjunctival telangiectasia (HP:0000524)1.69502714
144Tented upper lip vermilion (HP:0010804)1.68493122
145Ependymoma (HP:0002888)1.67768249
146Papillary thyroid carcinoma (HP:0002895)1.67213893
147Gastrointestinal carcinoma (HP:0002672)1.67193377
148Malignant gastrointestinal tract tumors (HP:0006749)1.67193377
149Shawl scrotum (HP:0000049)1.67079432
150Abnormality of the intervertebral disk (HP:0005108)1.66647022
151Pendular nystagmus (HP:0012043)1.66438926
152Anorexia (HP:0002039)1.66384166
153High anterior hairline (HP:0009890)1.66234940
154Lymphopenia (HP:0001888)1.66197142
155Leiomyosarcoma (HP:0100243)1.65506927
156Uterine leiomyosarcoma (HP:0002891)1.65506927
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.65030800
158Abnormality of the radial head (HP:0003995)1.64621322
159Acute lymphatic leukemia (HP:0006721)1.64520852
160Disinhibition (HP:0000734)1.64195769
161Abnormality of the heme biosynthetic pathway (HP:0010472)1.63487214
162Abnormality of the peritoneum (HP:0002585)1.63332687
163Neoplasm of striated muscle (HP:0009728)1.63171034
164Hypotelorism (HP:0000601)1.62699075
165Small hand (HP:0200055)1.62682635
166Septo-optic dysplasia (HP:0100842)1.62071025
167Cystic hygroma (HP:0000476)1.61879000
168Broad palm (HP:0001169)1.61466839
169Aplasia/Hypoplasia of the patella (HP:0006498)1.60925155
170Bruising susceptibility (HP:0000978)1.60418525
171Thoracolumbar scoliosis (HP:0002944)1.60146851
172Blepharitis (HP:0000498)1.60144049
173Deviation of the thumb (HP:0009603)1.59933628
174Proximal placement of thumb (HP:0009623)1.59783738
175Abnormality of the labia majora (HP:0012881)1.58936417
176Elfin facies (HP:0004428)1.58600748
177Nephroblastoma (Wilms tumor) (HP:0002667)1.58086253
178Transitional cell carcinoma of the bladder (HP:0006740)1.57525061
179Clubbing of toes (HP:0100760)1.57313559
180Renovascular hypertension (HP:0100817)1.57193775
181Microtia (HP:0008551)1.56888075
182Short middle phalanx of the 5th finger (HP:0004220)1.56026818
183Inappropriate behavior (HP:0000719)1.55238366
184Abnormality of incisor morphology (HP:0011063)1.55099426
185Short philtrum (HP:0000322)1.54510459
186Hypochromic microcytic anemia (HP:0004840)1.54102194
187Duodenal stenosis (HP:0100867)1.52444916
188Small intestinal stenosis (HP:0012848)1.52444916
189Abnormality of chromosome segregation (HP:0002916)1.51796582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.63153066
2RIPK45.07679690
3LATS13.39203829
4BRD43.03845530
5MAP2K32.88491069
6CDC72.77421803
7BLK2.74434709
8SIK32.65951228
9CAMK1D2.38299689
10CSK2.28809907
11MKNK22.25352440
12SIK22.20020936
13KSR22.13908761
14STK32.13475955
15FGR2.06201442
16CDK72.03015728
17MKNK11.98783202
18AKT31.98160880
19CHEK21.97908901
20CDK81.96455105
21CAMK1G1.93043493
22FES1.89482233
23NEK21.79870453
24ATR1.79699777
25TYK21.74457775
26TTK1.70401407
27MAP4K11.69521371
28CDK31.55496795
29KSR11.55165696
30ZAP701.50791131
31BTK1.50347235
32YES11.47716251
33SRPK11.46912462
34JAK21.42249228
35MAP3K61.41482550
36IRAK11.40140337
37BMPR21.37079095
38CDK61.35731491
39SYK1.33530092
40TGFBR21.31454510
41GRK61.24512099
42LATS21.24360277
43SGK2231.23545714
44SGK4941.23545714
45EIF2AK21.21849177
46RPS6KA41.21402907
47MAP3K31.20977302
48EPHB11.20719803
49TAOK11.19571434
50MAP3K141.19043178
51IRAK21.18868235
52ADRBK21.18253068
53MAP3K21.15866829
54CHEK11.15549953
55SGK21.15513510
56CDK41.13937941
57PIK3CG1.12136899
58SIK11.11553748
59ATM1.10202971
60ZAK1.07467418
61IKBKE1.05512012
62MAP3K11.05273424
63STK101.05239253
64MAP2K41.04545755
65RAF11.03852982
66PLK31.03348922
67STK41.03034670
68NUAK11.01713293
69LYN1.01253785
70MATK1.00369243
71ICK0.98623137
72JAK10.97123830
73JAK30.97006079
74SGK30.96772100
75MTOR0.96244984
76RET0.94631641
77PRPF4B0.92575901
78NLK0.92324443
79ERN10.92277346
80ALK0.89757284
81CDK20.88091772
82TXK0.87924243
83MAP3K50.86458956
84CSF1R0.86291189
85STK38L0.82762925
86BMX0.82523458
87DMPK0.81618027
88PLK10.80683779
89MAPK70.79619875
90TNK20.79512854
91STK240.77591095
92PIM10.77470818
93PTK2B0.77048013
94CAMK40.72610712
95IRAK40.71821386
96PKN20.70270640
97MAPK140.69867999
98CDK10.69810253
99LCK0.68683028
100CHUK0.68442579
101ERBB30.68087887
102PLK40.68030714
103DYRK30.67268860
104CDK90.66743970
105PDK10.65713960
106CSNK1D0.64178309
107MARK30.63828098
108CLK10.62274718
109MARK20.62150043
110WEE10.62104778
111INSRR0.61385118
112TEC0.60014999
113PTK60.58839355
114GSK3B0.58386324
115MAPK100.57881200
116AKT10.56817467
117CASK0.56785067
118EPHA20.55664736
119PAK40.54536764
120MAPK10.53889362
121TAOK30.53790880
122TAOK20.53696416
123VRK10.53484594
124EPHA30.50845219
125RPS6KL10.50752223
126RPS6KC10.50752223
127PLK20.48287356
128MAPK120.48180584
129IKBKB0.47449531
130DYRK1B0.47105920
131PDPK10.46986781
132AURKB0.46528621
133MAP3K70.46178326
134HIPK20.46145101
135ITK0.45812889
136STK110.44770929
137DDR20.44647802
138MARK10.44190393
139SGK10.43196893
140BMPR1B0.43009817
141PDGFRB0.42910058
142FGFR30.42062196
143MAP3K100.41751313
144FYN0.41464969
145FGFR10.40745773
146FGFR40.40521681
147RPS6KA60.40374248
148ERBB20.39370675
149PRKDC0.38847125
150TSSK60.38784890
151BRSK20.38421653
152WNK10.37902439
153HCK0.37787788
154KIT0.37156707
155MAPK130.36319378
156MAPK80.36151676
157MELK0.35931040
158RPS6KB10.35763480
159ACVR1B0.35544181
160PRKCZ0.32320794

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.23844769
2Mismatch repair_Homo sapiens_hsa034302.11043073
3Cell cycle_Homo sapiens_hsa041102.10121786
4DNA replication_Homo sapiens_hsa030302.07799345
5Homologous recombination_Homo sapiens_hsa034401.94486616
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76523116
7mRNA surveillance pathway_Homo sapiens_hsa030151.67578916
8RNA transport_Homo sapiens_hsa030131.63302030
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56514633
10Staphylococcus aureus infection_Homo sapiens_hsa051501.51221526
11Base excision repair_Homo sapiens_hsa034101.48800385
12MicroRNAs in cancer_Homo sapiens_hsa052061.47665674
13Malaria_Homo sapiens_hsa051441.45078588
14Spliceosome_Homo sapiens_hsa030401.42093204
15Basal cell carcinoma_Homo sapiens_hsa052171.41950633
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41498181
17Basal transcription factors_Homo sapiens_hsa030221.39764587
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39224258
19Adherens junction_Homo sapiens_hsa045201.38144746
20Non-homologous end-joining_Homo sapiens_hsa034501.36342240
21Colorectal cancer_Homo sapiens_hsa052101.36211567
22Notch signaling pathway_Homo sapiens_hsa043301.33375548
23Legionellosis_Homo sapiens_hsa051341.31307915
24RNA degradation_Homo sapiens_hsa030181.27748231
25Herpes simplex infection_Homo sapiens_hsa051681.27716910
26VEGF signaling pathway_Homo sapiens_hsa043701.26745061
27p53 signaling pathway_Homo sapiens_hsa041151.26344455
28Chronic myeloid leukemia_Homo sapiens_hsa052201.25132588
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21064926
30Wnt signaling pathway_Homo sapiens_hsa043101.20115647
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.17835641
32Hedgehog signaling pathway_Homo sapiens_hsa043401.17499158
33Nucleotide excision repair_Homo sapiens_hsa034201.16789328
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15226325
35Hippo signaling pathway_Homo sapiens_hsa043901.10463961
36Lysine degradation_Homo sapiens_hsa003101.09097665
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.06015993
38TGF-beta signaling pathway_Homo sapiens_hsa043501.05970107
39Endometrial cancer_Homo sapiens_hsa052131.05101999
40Phagosome_Homo sapiens_hsa041451.04916155
41HTLV-I infection_Homo sapiens_hsa051661.04086403
42Pancreatic cancer_Homo sapiens_hsa052121.03664457
43Small cell lung cancer_Homo sapiens_hsa052221.03036046
44mTOR signaling pathway_Homo sapiens_hsa041501.02713370
45Prostate cancer_Homo sapiens_hsa052151.01569172
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01229817
47Hepatitis C_Homo sapiens_hsa051600.95796267
48GnRH signaling pathway_Homo sapiens_hsa049120.94465686
49Pathways in cancer_Homo sapiens_hsa052000.93485054
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.93268569
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92286414
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91781240
53Non-small cell lung cancer_Homo sapiens_hsa052230.91737634
54Melanoma_Homo sapiens_hsa052180.91224146
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91207021
56Hepatitis B_Homo sapiens_hsa051610.90308019
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89901846
58Leishmaniasis_Homo sapiens_hsa051400.89008391
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88987066
60B cell receptor signaling pathway_Homo sapiens_hsa046620.88716542
61Acute myeloid leukemia_Homo sapiens_hsa052210.87815765
62ErbB signaling pathway_Homo sapiens_hsa040120.87722552
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87548924
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.87020329
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.85798563
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84884967
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83760551
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83519982
69Amoebiasis_Homo sapiens_hsa051460.83253137
70Measles_Homo sapiens_hsa051620.82240692
71Long-term potentiation_Homo sapiens_hsa047200.82136539
72Osteoclast differentiation_Homo sapiens_hsa043800.81756459
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81424222
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81201178
75Apoptosis_Homo sapiens_hsa042100.81115105
76African trypanosomiasis_Homo sapiens_hsa051430.80603939
77Renal cell carcinoma_Homo sapiens_hsa052110.79687253
78FoxO signaling pathway_Homo sapiens_hsa040680.79464718
79One carbon pool by folate_Homo sapiens_hsa006700.78659029
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77710402
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77134188
82Dorso-ventral axis formation_Homo sapiens_hsa043200.76481824
83Glioma_Homo sapiens_hsa052140.75167795
84Inositol phosphate metabolism_Homo sapiens_hsa005620.74754360
85HIF-1 signaling pathway_Homo sapiens_hsa040660.74444399
86Estrogen signaling pathway_Homo sapiens_hsa049150.74071874
87Long-term depression_Homo sapiens_hsa047300.72890438
88MAPK signaling pathway_Homo sapiens_hsa040100.72728565
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72613667
90Salmonella infection_Homo sapiens_hsa051320.72462204
91Axon guidance_Homo sapiens_hsa043600.71773260
92Viral carcinogenesis_Homo sapiens_hsa052030.71578513
93Hematopoietic cell lineage_Homo sapiens_hsa046400.69603610
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69443832
95Primary immunodeficiency_Homo sapiens_hsa053400.68027030
96Shigellosis_Homo sapiens_hsa051310.68025866
97Endocytosis_Homo sapiens_hsa041440.68002736
98Choline metabolism in cancer_Homo sapiens_hsa052310.67783599
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66348609
100Bladder cancer_Homo sapiens_hsa052190.66235385
101Viral myocarditis_Homo sapiens_hsa054160.66174494
102Oocyte meiosis_Homo sapiens_hsa041140.66172160
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66068522
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.65964635
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65622923
106Rap1 signaling pathway_Homo sapiens_hsa040150.65250592
107Chemokine signaling pathway_Homo sapiens_hsa040620.64905816
108Graft-versus-host disease_Homo sapiens_hsa053320.64894398
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.63753934
110Proteoglycans in cancer_Homo sapiens_hsa052050.63525546
111Influenza A_Homo sapiens_hsa051640.63164698
112Insulin signaling pathway_Homo sapiens_hsa049100.62986274
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61489818
114Epstein-Barr virus infection_Homo sapiens_hsa051690.60733911
115T cell receptor signaling pathway_Homo sapiens_hsa046600.59906008
116Gap junction_Homo sapiens_hsa045400.59228079
117TNF signaling pathway_Homo sapiens_hsa046680.58911738
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.58710405
119Ras signaling pathway_Homo sapiens_hsa040140.58191515
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57822506
121Circadian rhythm_Homo sapiens_hsa047100.57792722
122Phototransduction_Homo sapiens_hsa047440.57630357
123Prolactin signaling pathway_Homo sapiens_hsa049170.57607331
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56999619
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.56701602
126Tuberculosis_Homo sapiens_hsa051520.56563660
127Toxoplasmosis_Homo sapiens_hsa051450.54677671
128Insulin resistance_Homo sapiens_hsa049310.54572984
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52934728
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52520645
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52196669
132Allograft rejection_Homo sapiens_hsa053300.51976994
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51877767
134Platelet activation_Homo sapiens_hsa046110.50745518
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50222380
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49809191
137Thyroid cancer_Homo sapiens_hsa052160.49767725
138Type II diabetes mellitus_Homo sapiens_hsa049300.48557521

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