ZBTB38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.58827866
2negative regulation of dendrite morphogenesis (GO:0050774)5.16366699
3presynaptic membrane organization (GO:0097090)4.77021830
4postsynaptic membrane organization (GO:0001941)4.70263187
5inositol phosphate catabolic process (GO:0071545)4.13533846
6cell adhesion mediated by integrin (GO:0033627)4.08605185
7regulation of relaxation of muscle (GO:1901077)4.07337405
8negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82245761
9hemidesmosome assembly (GO:0031581)3.79510050
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64962438
11negative regulation of dendrite development (GO:2000171)3.61311913
12positive regulation of protein homodimerization activity (GO:0090073)3.48757085
13macroautophagy (GO:0016236)3.41967853
14COPII vesicle coating (GO:0048208)3.41221939
15regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.39792944
16membrane raft organization (GO:0031579)3.39661349
17regulation of cell communication by electrical coupling (GO:0010649)3.38788280
18ER overload response (GO:0006983)3.36707135
19regulation of germinal center formation (GO:0002634)3.32440509
20protein localization to cilium (GO:0061512)3.30376437
21interleukin-6-mediated signaling pathway (GO:0070102)3.30053915
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.29056868
23dentate gyrus development (GO:0021542)3.28720012
24viral protein processing (GO:0019082)3.27754462
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.23214254
26inositol phosphate dephosphorylation (GO:0046855)3.23214254
27regulation of cardiac muscle hypertrophy (GO:0010611)3.21718307
28cell-substrate junction assembly (GO:0007044)3.17074826
29positive regulation of cardiac muscle cell differentiation (GO:2000727)3.15362888
30positive regulation of cardiac muscle hypertrophy (GO:0010613)3.13386770
31positive regulation of muscle hypertrophy (GO:0014742)3.13386770
32pericardium development (GO:0060039)3.12365142
33mannosylation (GO:0097502)3.10287901
34signal peptide processing (GO:0006465)3.08412549
35smooth muscle tissue development (GO:0048745)3.08396532
36regulation of muscle hypertrophy (GO:0014743)3.08365712
37protein complex biogenesis (GO:0070271)3.06538479
38cellular response to vitamin (GO:0071295)3.03530009
39chondrocyte proliferation (GO:0035988)3.02628530
40histamine secretion (GO:0001821)3.02552719
41platelet-derived growth factor receptor signaling pathway (GO:0048008)3.01919017
42neurotransmitter-gated ion channel clustering (GO:0072578)3.01757038
43mitochondrion distribution (GO:0048311)3.01180459
44cellular response to vitamin D (GO:0071305)2.99371674
45rRNA methylation (GO:0031167)2.97368382
46skin morphogenesis (GO:0043589)2.97020582
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95380626
48negative regulation of mast cell activation (GO:0033004)2.94444806
49startle response (GO:0001964)2.93911438
50membrane assembly (GO:0071709)2.93247852
51negative regulation of neurotransmitter secretion (GO:0046929)2.90960697
52neuron cell-cell adhesion (GO:0007158)2.89684753
53protein localization to endosome (GO:0036010)2.89604485
54regulation of type B pancreatic cell apoptotic process (GO:2000674)2.88814072
55lipid translocation (GO:0034204)2.87951229
56phospholipid translocation (GO:0045332)2.87951229
57definitive hemopoiesis (GO:0060216)2.86217527
58negative regulation of anoikis (GO:2000811)2.86202113
59apoptotic cell clearance (GO:0043277)2.84348505
60polyketide metabolic process (GO:0030638)2.83482279
61doxorubicin metabolic process (GO:0044598)2.83482279
62daunorubicin metabolic process (GO:0044597)2.83482279
63fibroblast migration (GO:0010761)2.82501444
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82298048
65mitochondrial respiratory chain complex I assembly (GO:0032981)2.82298048
66NADH dehydrogenase complex assembly (GO:0010257)2.82298048
67glomerular visceral epithelial cell development (GO:0072015)2.79504541
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.79128398
69COPI coating of Golgi vesicle (GO:0048205)2.77793721
70Golgi transport vesicle coating (GO:0048200)2.77793721
71hypotonic response (GO:0006971)2.75680636
72negative regulation of systemic arterial blood pressure (GO:0003085)2.75251083
73glomerular basement membrane development (GO:0032836)2.75016059
74protein K11-linked deubiquitination (GO:0035871)2.71814576
75substrate-dependent cell migration (GO:0006929)2.70982314
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.68620815
77negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67369097
78endodermal cell differentiation (GO:0035987)2.66639662
79mesodermal cell differentiation (GO:0048333)2.65506745
80desmosome organization (GO:0002934)2.65328373
81regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.65215799
82germinal center formation (GO:0002467)2.65011863
83positive regulation of endothelial cell apoptotic process (GO:2000353)2.64808597
84energy homeostasis (GO:0097009)2.64332360
85L-fucose catabolic process (GO:0042355)2.64003092
86fucose catabolic process (GO:0019317)2.64003092
87L-fucose metabolic process (GO:0042354)2.64003092
88cytochrome complex assembly (GO:0017004)2.63880247
89negative regulation of neurotransmitter transport (GO:0051589)2.63504491
90regulation of transforming growth factor beta1 production (GO:0032908)2.63102977
91mitochondrial respiratory chain complex assembly (GO:0033108)2.61270335
92rhodopsin mediated signaling pathway (GO:0016056)2.60411417
93intraciliary transport (GO:0042073)2.59846032
94serotonin receptor signaling pathway (GO:0007210)2.59232930
95transferrin transport (GO:0033572)2.59187259
96negative regulation of phagocytosis (GO:0050765)2.59079072
97regulation of transforming growth factor beta2 production (GO:0032909)2.58094359
98regulation of alkaline phosphatase activity (GO:0010692)2.58081661
99protein hydroxylation (GO:0018126)2.56988858
100regulation of anoikis (GO:2000209)2.56767196
101UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54770858
102vocalization behavior (GO:0071625)2.54051463
103dendritic cell chemotaxis (GO:0002407)2.53660441
104facial nerve structural organization (GO:0021612)2.52272107
105positive regulation of fibroblast migration (GO:0010763)2.51930395
106respiratory chain complex IV assembly (GO:0008535)2.51859465
107sympathetic nervous system development (GO:0048485)2.51487750
108negative regulation of fatty acid transport (GO:2000192)2.50862405
109regulation of sarcomere organization (GO:0060297)2.47184586
110blood vessel maturation (GO:0001955)2.46303464
111histamine transport (GO:0051608)2.46263966
112negative regulation of osteoblast proliferation (GO:0033689)2.46251576
113negative regulation of myoblast differentiation (GO:0045662)2.45002558
114cAMP catabolic process (GO:0006198)2.44904474
115megakaryocyte development (GO:0035855)2.43106516
116regulation of early endosome to late endosome transport (GO:2000641)2.42399524
117positive regulation of p38MAPK cascade (GO:1900745)2.42192344
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41764898
119negative regulation of keratinocyte proliferation (GO:0010839)2.41708920
120trivalent inorganic cation transport (GO:0072512)2.41635189
121ferric iron transport (GO:0015682)2.41635189
122nucleotide transmembrane transport (GO:1901679)2.41577336
123sprouting angiogenesis (GO:0002040)2.41441659
124behavioral response to pain (GO:0048266)2.40783139
125collagen fibril organization (GO:0030199)2.40775272
126regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.39962795
127mechanosensory behavior (GO:0007638)2.39770825
128negative regulation of glycogen biosynthetic process (GO:0045719)2.39637662
129negative regulation of complement activation (GO:0045916)2.38918562
130vesicle coating (GO:0006901)2.38619851
131import into cell (GO:0098657)2.38540245
132cyclic nucleotide catabolic process (GO:0009214)2.37775593
133inner ear receptor stereocilium organization (GO:0060122)2.37114483
134endocytic recycling (GO:0032456)2.36958690
135actin filament depolymerization (GO:0030042)2.36614074
136regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.35407351
137Rap protein signal transduction (GO:0032486)2.34958096
138long-term synaptic potentiation (GO:0060291)2.34937918
139regulation of muscle adaptation (GO:0043502)2.34681043
140urinary tract smooth muscle contraction (GO:0014848)2.33941076
141extracellular matrix assembly (GO:0085029)2.33736597
142peptidyl-proline hydroxylation (GO:0019511)2.33009195
143cullin deneddylation (GO:0010388)2.32517176
144positive regulation of myoblast differentiation (GO:0045663)2.32505088
145peripheral nervous system neuron development (GO:0048935)2.31469653
146oligosaccharide biosynthetic process (GO:0009312)2.31304240
147activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.31285743
148regulation of action potential (GO:0098900)2.31197228
149negative regulation of protein localization to plasma membrane (GO:1903077)2.31095329
150dendritic cell migration (GO:0036336)2.30435762
151positive regulation of synapse assembly (GO:0051965)2.30230432
152retina vasculature morphogenesis in camera-type eye (GO:0061299)2.29966786
153actin cytoskeleton reorganization (GO:0031532)2.29810149
154regulation of synaptic vesicle exocytosis (GO:2000300)2.29690679
155phagosome maturation (GO:0090382)2.29566132
156substrate adhesion-dependent cell spreading (GO:0034446)2.29473127
157focal adhesion assembly (GO:0048041)2.28605287
158cell-substrate adherens junction assembly (GO:0007045)2.28605287
159positive regulation of axon extension (GO:0045773)2.28353665
160gonadal mesoderm development (GO:0007506)2.28335827
161regulation of synapse assembly (GO:0051963)2.27913184
162glomerular epithelial cell development (GO:0072310)2.27715388
163negative regulation of T-helper cell differentiation (GO:0045623)2.26582650
164negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.26582650
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.26012976
166extracellular regulation of signal transduction (GO:1900115)2.25999455
167extracellular negative regulation of signal transduction (GO:1900116)2.25999455
168sequestering of extracellular ligand from receptor (GO:0035581)2.25955576
169interkinetic nuclear migration (GO:0022027)2.25734074
170Golgi organization (GO:0007030)2.24653046
171inositol phosphate-mediated signaling (GO:0048016)2.22698125
172cellular response to ethanol (GO:0071361)2.21519839
173establishment of protein localization to Golgi (GO:0072600)2.20580244
174positive regulation of protein autophosphorylation (GO:0031954)2.20379538
175protein targeting to Golgi (GO:0000042)2.17502833
176SMAD protein complex assembly (GO:0007183)2.17411567
177insulin-like growth factor receptor signaling pathway (GO:0048009)2.16523385
178regulation of glucose import in response to insulin stimulus (GO:2001273)2.16291487
179negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.15824193
180endoplasmic reticulum organization (GO:0007029)2.15154696
181vesicle transport along microtubule (GO:0047496)2.14832484
182negative regulation of protein activation cascade (GO:2000258)2.13543884
183retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13274272
184positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.12961506
185endocardial cushion development (GO:0003197)2.12804948
186regulation of extracellular matrix disassembly (GO:0010715)2.12111501
187serine transport (GO:0032329)2.09303950
188CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.08813572
189positive regulation of osteoblast proliferation (GO:0033690)2.08687712
190mesenchymal-epithelial cell signaling (GO:0060638)2.08602490
191endoplasmic reticulum unfolded protein response (GO:0030968)2.06372084
192positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.05717228
193nerve growth factor signaling pathway (GO:0038180)2.03861376
194Golgi to plasma membrane protein transport (GO:0043001)2.03408247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.55760617
2TAF15_26573619_Chip-Seq_HEK293_Human3.10295471
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.06818311
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.04317465
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93121795
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67357411
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.60167307
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56707461
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46021152
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43268689
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42222297
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.41646568
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40985115
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.36713701
15P300_19829295_ChIP-Seq_ESCs_Human2.31651012
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17941299
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13385017
18* CJUN_26792858_Chip-Seq_BT549_Human2.12265017
19TP53_16413492_ChIP-PET_HCT116_Human2.10799372
20BRD4_25478319_ChIP-Seq_HGPS_Human2.09321832
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05293591
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.00800521
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00465696
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96860163
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96112802
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93454094
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.92921534
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.91450989
29FUS_26573619_Chip-Seq_HEK293_Human1.89176062
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84433684
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84433684
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.83252784
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82236608
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81673228
35AR_21572438_ChIP-Seq_LNCaP_Human1.79837090
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.74327844
37* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74125635
38ER_23166858_ChIP-Seq_MCF-7_Human1.74008222
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73093902
40CTNNB1_20460455_ChIP-Seq_HCT116_Human1.72306608
41* AHR_22903824_ChIP-Seq_MCF-7_Human1.70108788
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.68656688
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67846711
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67151821
45P53_22387025_ChIP-Seq_ESCs_Mouse1.65440411
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64360549
47EWS_26573619_Chip-Seq_HEK293_Human1.64336887
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64216910
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.64162871
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63157564
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.62989362
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.59630506
53* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58186185
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57724877
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57440772
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57225403
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.56166891
58EZH2_22144423_ChIP-Seq_EOC_Human1.53471022
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53102617
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.52815039
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.51079344
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47888577
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47778563
64RNF2_27304074_Chip-Seq_NSC_Mouse1.47020383
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.46544523
66* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44967405
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.44244417
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44020104
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43847777
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43534802
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41829863
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41312069
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41207865
74* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40533625
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40524531
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39692689
77P300_18555785_Chip-Seq_ESCs_Mouse1.39442569
78* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39380512
79* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39341220
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38612051
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38283029
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37778692
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37778692
84* GATA2_21666600_ChIP-Seq_HMVEC_Human1.36635541
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.35828783
86* TP63_23658742_ChIP-Seq_EP156T_Human1.34998619
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.34600637
88* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33665135
89IRF1_19129219_ChIP-ChIP_H3396_Human1.33642711
90* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33410059
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.33024873
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.32898360
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32511184
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32331210
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31918164
96IGF1R_20145208_ChIP-Seq_DFB_Human1.31866850
97TP53_18474530_ChIP-ChIP_U2OS_Human1.31729930
98AR_25329375_ChIP-Seq_VCAP_Human1.30351500
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28435424
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.28141078
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27637972
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26899576
103STAT3_23295773_ChIP-Seq_U87_Human1.25577294
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.25154997
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.25115433
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24830761
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24818465
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24666464
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24171681
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23907320
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.22020481
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21716996
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20989801
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20976118
115SOX2_20726797_ChIP-Seq_SW620_Human1.20491028
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20330248
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19109983
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18820716
119* TCF4_23295773_ChIP-Seq_U87_Human1.18087973
120JUN_21703547_ChIP-Seq_K562_Human1.17912906
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17390087
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.16892819
123TBX20_22328084_ChIP-Seq_HEART_Mouse1.15839715
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.15839715
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.15733487
126PU1_27457419_Chip-Seq_LIVER_Mouse1.15609288
127NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15379920
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13906001
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13626462
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12741709
131KDM2B_26808549_Chip-Seq_REH_Human1.12423600
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.12380746
133RUNX2_22187159_ChIP-Seq_PCA_Human1.12001809
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.11531047
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.10891680
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10652597
137CLOCK_20551151_ChIP-Seq_293T_Human1.09967347
138ESR2_21235772_ChIP-Seq_MCF-7_Human1.09879151
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09044430
140MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08997630
141P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08538135
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08106952
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08006801
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07841176
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06934614
146* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05831056
147RUNX_20019798_ChIP-Seq_JUKART_Human1.04954756
148SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04745943
149CTCF_18555785_Chip-Seq_ESCs_Mouse1.04632112
150SOX9_26525672_Chip-Seq_HEART_Mouse1.04512379
151ZFX_18555785_Chip-Seq_ESCs_Mouse1.04173897
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03354378
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01564809
154NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00002615
155CDX2_20551321_ChIP-Seq_CACO-2_Human0.99968850
156EGR1_19374776_ChIP-ChIP_THP-1_Human0.97741352
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97675483
158RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97598957
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.97290345
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97038071
161VDR_24787735_ChIP-Seq_THP-1_Human0.96341764
162YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95887824
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95563619
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94654084
165SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93390994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.26658073
2MP0005646_abnormal_pituitary_gland3.27875235
3MP0010352_gastrointestinal_tract_polyps3.05983945
4MP0003091_abnormal_cell_migration3.05876340
5MP0004272_abnormal_basement_membrane3.00096709
6MP0001986_abnormal_taste_sensitivity2.89061589
7MP0002876_abnormal_thyroid_physiology2.88445219
8MP0005171_absent_coat_pigmentation2.84754448
9MP0003566_abnormal_cell_adhesion2.76122698
10MP0000569_abnormal_digit_pigmentation2.71202843
11MP0003300_gastrointestinal_ulcer2.54242951
12MP0002009_preneoplasia2.53126647
13MP0005623_abnormal_meninges_morphology2.52277483
14MP0010234_abnormal_vibrissa_follicle2.52230949
15MP0003787_abnormal_imprinting2.49994439
16MP0003045_fibrosis2.49754247
17MP0000013_abnormal_adipose_tissue2.45527567
18MP0003880_abnormal_central_pattern2.44334035
19MP0005503_abnormal_tendon_morphology2.44087904
20MP0005023_abnormal_wound_healing2.26993804
21MP0003705_abnormal_hypodermis_morpholog2.26726315
22MP0009697_abnormal_copulation2.25349632
23MP0005409_darkened_coat_color2.19609794
24MP0000015_abnormal_ear_pigmentation2.16511229
25MP0002735_abnormal_chemical_nociception2.13102617
26MP0001968_abnormal_touch/_nociception2.11294210
27MP0003183_abnormal_peptide_metabolism2.10588827
28MP0002736_abnormal_nociception_after2.06002597
29MP0001984_abnormal_olfaction2.01500589
30MP0001348_abnormal_lacrimal_gland1.98607668
31MP0000003_abnormal_adipose_tissue1.85600874
32MP0002163_abnormal_gland_morphology1.81123555
33MP0002877_abnormal_melanocyte_morpholog1.77989781
34MP0002168_other_aberrant_phenotype1.77344703
35MP0004147_increased_porphyrin_level1.76159052
36MP0006292_abnormal_olfactory_placode1.74582431
37MP0000681_abnormal_thyroid_gland1.74143718
38MP0003868_abnormal_feces_composition1.71457723
39MP0001542_abnormal_bone_strength1.69512549
40MP0003943_abnormal_hepatobiliary_system1.65467835
41MP0004782_abnormal_surfactant_physiolog1.60442954
42MP0002132_abnormal_respiratory_system1.59890083
43MP0005257_abnormal_intraocular_pressure1.59425776
44MP0004134_abnormal_chest_morphology1.59060606
45MP0002734_abnormal_mechanical_nocicepti1.58039812
46MP0009780_abnormal_chondrocyte_physiolo1.54732218
47MP0001879_abnormal_lymphatic_vessel1.53691579
48MP0009745_abnormal_behavioral_response1.49967413
49MP0000767_abnormal_smooth_muscle1.49805377
50MP0002332_abnormal_exercise_endurance1.47189522
51MP0000685_abnormal_immune_system1.47003795
52MP0001905_abnormal_dopamine_level1.46710079
53MP0002166_altered_tumor_susceptibility1.46614800
54MP0004084_abnormal_cardiac_muscle1.46195714
55MP0004270_analgesia1.45648805
56MP0002060_abnormal_skin_morphology1.45160538
57MP0006276_abnormal_autonomic_nervous1.43085889
58MP0002896_abnormal_bone_mineralization1.39084350
59MP0005084_abnormal_gallbladder_morpholo1.37839378
60MP0002272_abnormal_nervous_system1.37790419
61MP0009046_muscle_twitch1.34834516
62MP0000749_muscle_degeneration1.31448393
63MP0000372_irregular_coat_pigmentation1.30216810
64MP0002095_abnormal_skin_pigmentation1.29997739
65MP0004484_altered_response_of1.29008926
66MP0003724_increased_susceptibility_to1.27298132
67MP0005379_endocrine/exocrine_gland_phen1.25709448
68MP0003136_yellow_coat_color1.22526015
69MP0009379_abnormal_foot_pigmentation1.20682583
70MP0008004_abnormal_stomach_pH1.20306454
71MP0002067_abnormal_sensory_capabilities1.20167093
72MP0002572_abnormal_emotion/affect_behav1.20124572
73MP0010678_abnormal_skin_adnexa1.17936298
74MP0000751_myopathy1.16243055
75MP0000566_synostosis1.14879090
76MP0005367_renal/urinary_system_phenotyp1.14519361
77MP0000516_abnormal_urinary_system1.14519361
78MP0004036_abnormal_muscle_relaxation1.12817938
79MP0001177_atelectasis1.12810386
80MP0000733_abnormal_muscle_development1.12728026
81MP0002064_seizures1.12155785
82MP0003252_abnormal_bile_duct1.11968672
83MP0002822_catalepsy1.11583737
84MP0002295_abnormal_pulmonary_circulatio1.11297983
85MP0005165_increased_susceptibility_to1.10915165
86MP0010386_abnormal_urinary_bladder1.10158489
87MP0002998_abnormal_bone_remodeling1.09635404
88MP0010368_abnormal_lymphatic_system1.09353360
89MP0002006_tumorigenesis1.09287833
90MP0001919_abnormal_reproductive_system1.08458367
91MP0001963_abnormal_hearing_physiology1.06371507
92MP0003635_abnormal_synaptic_transmissio1.04208614
93MP0004510_myositis1.01888570
94MP0001501_abnormal_sleep_pattern1.01484075
95MP0002063_abnormal_learning/memory/cond1.00434366
96MP0005645_abnormal_hypothalamus_physiol0.98118044
97MP0005375_adipose_tissue_phenotype0.97134456
98MP0008877_abnormal_DNA_methylation0.97005696
99MP0008057_abnormal_DNA_replication0.96933138
100MP0001299_abnormal_eye_distance/0.96001430
101MP0001486_abnormal_startle_reflex0.95097985
102MP0005499_abnormal_olfactory_system0.93127995
103MP0005394_taste/olfaction_phenotype0.93127995
104MP0002108_abnormal_muscle_morphology0.91779077
105MP0002933_joint_inflammation0.91655350
106MP0009250_abnormal_appendicular_skeleto0.91444314
107MP0008438_abnormal_cutaneous_collagen0.90941402
108MP0002751_abnormal_autonomic_nervous0.90634855
109MP0005551_abnormal_eye_electrophysiolog0.89481422
110MP0003279_aneurysm0.89040497
111MP0006054_spinal_hemorrhage0.88825473
112MP0003453_abnormal_keratinocyte_physiol0.87352827
113MP0008569_lethality_at_weaning0.87345824
114MP0003950_abnormal_plasma_membrane0.87213951
115MP0002160_abnormal_reproductive_system0.86384795
116MP0005174_abnormal_tail_pigmentation0.86235374
117MP0002972_abnormal_cardiac_muscle0.83324110
118MP0005621_abnormal_cell_physiology0.83171112
119MP0005076_abnormal_cell_differentiation0.82737087
120MP0009840_abnormal_foam_cell0.82178494
121MP0000759_abnormal_skeletal_muscle0.82061260
122MP0000249_abnormal_blood_vessel0.81746881
123MP0003828_pulmonary_edema0.81691635
124MP0005075_abnormal_melanosome_morpholog0.80412866
125MP0008789_abnormal_olfactory_epithelium0.79368556
126MP0005389_reproductive_system_phenotype0.79358714
127MP0004085_abnormal_heartbeat0.79167532
128MP0005671_abnormal_response_to0.79096869
129MP0003786_premature_aging0.78889581
130MP0000920_abnormal_myelination0.78342435
131MP0003191_abnormal_cellular_cholesterol0.78238908
132MP0000631_abnormal_neuroendocrine_gland0.78202544
133MP0000026_abnormal_inner_ear0.76882256
134MP0002938_white_spotting0.75977645
135MP0000230_abnormal_systemic_arterial0.75650084
136MP0004142_abnormal_muscle_tone0.74944218
137MP0001790_abnormal_immune_system0.74248901
138MP0005387_immune_system_phenotype0.74248901
139MP0004808_abnormal_hematopoietic_stem0.73849239
140MP0002128_abnormal_blood_circulation0.73837041
141MP0004043_abnormal_pH_regulation0.73663153
142MP0001502_abnormal_circadian_rhythm0.73471721
143MP0001661_extended_life_span0.72698795
144MP0005620_abnormal_muscle_contractility0.71200631
145MP0002269_muscular_atrophy0.70856847
146MP0005451_abnormal_body_composition0.70644809
147MP0008260_abnormal_autophagy0.70272929
148MP0005164_abnormal_response_to0.69488038
149MP0005595_abnormal_vascular_smooth0.68736186
150MP0005386_behavior/neurological_phenoty0.68693824
151MP0004924_abnormal_behavior0.68693824
152MP0001958_emphysema0.68093668
153MP0005275_abnormal_skin_tensile0.67812775
154MP0004087_abnormal_muscle_fiber0.67528924
155MP0003763_abnormal_thymus_physiology0.67417632
156MP0002971_abnormal_brown_adipose0.66717552
157MP0002139_abnormal_hepatobiliary_system0.65534685
158MP0004883_abnormal_blood_vessel0.65114044
159MP0002133_abnormal_respiratory_system0.65102258
160MP0001243_abnormal_dermal_layer0.64988534
161MP0004215_abnormal_myocardial_fiber0.63644925
162MP0001191_abnormal_skin_condition0.62280165
163MP0001915_intracranial_hemorrhage0.61734337
164MP0001851_eye_inflammation0.61661972
165MP0003795_abnormal_bone_structure0.61455185
166MP0005508_abnormal_skeleton_morphology0.60742257
167MP0003941_abnormal_skin_development0.59754428
168MP0001614_abnormal_blood_vessel0.59636803
169MP0006138_congestive_heart_failure0.59515502
170MP0003303_peritoneal_inflammation0.58780909
171MP0005360_urolithiasis0.58152968
172MP0000371_diluted_coat_color0.58012501
173MP0009384_cardiac_valve_regurgitation0.57924098
174MP0004947_skin_inflammation0.57352587
175MP0003633_abnormal_nervous_system0.57209430
176MP0002138_abnormal_hepatobiliary_system0.56987812

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.50559947
2Hypothermia (HP:0002045)4.26065769
3Aortic aneurysm (HP:0004942)4.14738500
4Abnormal hair whorl (HP:0010721)4.10081299
5Febrile seizures (HP:0002373)3.99423639
6Aortic dissection (HP:0002647)3.98287480
7Premature rupture of membranes (HP:0001788)3.85125207
8Focal motor seizures (HP:0011153)3.76656775
9Hyperventilation (HP:0002883)3.65092672
10Vascular tortuosity (HP:0004948)3.63575686
11Arterial tortuosity (HP:0005116)3.58338510
12Osteolytic defects of the phalanges of the hand (HP:0009771)3.52266801
13Osteolytic defects of the hand bones (HP:0009699)3.52266801
14Epileptic encephalopathy (HP:0200134)3.45414243
15Abnormality of incisor morphology (HP:0011063)3.35519093
16Atrophic scars (HP:0001075)3.33060160
17Mitral stenosis (HP:0001718)3.24221592
18Wormian bones (HP:0002645)3.10690092
19Atonic seizures (HP:0010819)3.07410050
20Alveolar cell carcinoma (HP:0006519)3.07354867
21Medial flaring of the eyebrow (HP:0010747)2.92265385
22Nephrogenic diabetes insipidus (HP:0009806)2.89694679
23Follicular hyperkeratosis (HP:0007502)2.83259808
24Spondylolisthesis (HP:0003302)2.75523993
25Abnormality of the nasal septum (HP:0000419)2.75174265
26Congenital primary aphakia (HP:0007707)2.73620467
27Type I transferrin isoform profile (HP:0003642)2.72050971
28Protruding tongue (HP:0010808)2.71511480
29Vertebral compression fractures (HP:0002953)2.68323767
30Cardiovascular calcification (HP:0011915)2.68171959
31Gait imbalance (HP:0002141)2.65927760
32Nonprogressive disorder (HP:0003680)2.64456321
33Spinal rigidity (HP:0003306)2.60243950
34Irregular epiphyses (HP:0010582)2.59082623
35Hyperkalemia (HP:0002153)2.58437429
36Neonatal short-limb short stature (HP:0008921)2.56849079
37Type 1 muscle fiber predominance (HP:0003803)2.56529812
38Fragile skin (HP:0001030)2.52554628
39Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.51383612
40Abnormality of the frontal sinuses (HP:0002687)2.50163843
41Ankle contracture (HP:0006466)2.49013149
42Bradycardia (HP:0001662)2.48069874
43Glucose intolerance (HP:0000833)2.47831056
44Aplasia/Hypoplasia of the lens (HP:0008063)2.43660446
45Increased connective tissue (HP:0009025)2.42466182
46Overgrowth (HP:0001548)2.41990133
47Tubulointerstitial nephritis (HP:0001970)2.40433815
48Cervical subluxation (HP:0003308)2.39338724
49Neoplasm of the tracheobronchial system (HP:0100552)2.35651921
50Absent frontal sinuses (HP:0002688)2.35284260
51Abnormality of the columella (HP:0009929)2.35100232
52Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.34829578
53Type 2 muscle fiber atrophy (HP:0003554)2.34675058
54Generalized hypopigmentation of hair (HP:0011358)2.33900958
55Aneurysm (HP:0002617)2.33879652
56Hyporeflexia of lower limbs (HP:0002600)2.33791118
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.31117181
58Asymmetry of the thorax (HP:0001555)2.30107348
59True hermaphroditism (HP:0010459)2.28737304
60Dilatation of the ascending aorta (HP:0005111)2.27679190
61Fair hair (HP:0002286)2.26695416
62Short chin (HP:0000331)2.26331314
63Poor coordination (HP:0002370)2.25939164
64Renal Fanconi syndrome (HP:0001994)2.23647130
65Progressive macrocephaly (HP:0004481)2.22840262
66Weak cry (HP:0001612)2.21697296
67Acute necrotizing encephalopathy (HP:0006965)2.21604202
68Mitochondrial inheritance (HP:0001427)2.21161915
69Aortic regurgitation (HP:0001659)2.20727514
70Patchy hypopigmentation of hair (HP:0011365)2.20665164
71Autoamputation (HP:0001218)2.18250803
72Pancreatic fibrosis (HP:0100732)2.18153386
73Submucous cleft hard palate (HP:0000176)2.17328159
74Blue irides (HP:0000635)2.17050487
75White forelock (HP:0002211)2.17033444
76Tetraparesis (HP:0002273)2.16920782
77Neonatal hypoglycemia (HP:0001998)2.15199455
78Microvesicular hepatic steatosis (HP:0001414)2.14957446
79Persistence of primary teeth (HP:0006335)2.14832948
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.11813520
81Mildly elevated creatine phosphokinase (HP:0008180)2.11154464
82Distal lower limb amyotrophy (HP:0008944)2.10841530
83Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.10245918
84Bladder diverticulum (HP:0000015)2.09178544
85Vascular calcification (HP:0004934)2.07951976
86Soft skin (HP:0000977)2.06974906
87Thoracolumbar scoliosis (HP:0002944)2.06044974
88Scanning speech (HP:0002168)2.05741741
89Striae distensae (HP:0001065)2.05617744
90Long clavicles (HP:0000890)2.05073170
91Nuclear cataract (HP:0100018)2.02939045
92Flat acetabular roof (HP:0003180)2.02785570
93Distal lower limb muscle weakness (HP:0009053)2.02743022
94Neuroendocrine neoplasm (HP:0100634)2.02357006
95Short tibia (HP:0005736)1.99871232
96Spinal cord lesions (HP:0100561)1.99333635
97Syringomyelia (HP:0003396)1.99333635
98Abnormal mitochondria in muscle tissue (HP:0008316)1.98501372
99Cerebral aneurysm (HP:0004944)1.97382217
100Mild short stature (HP:0003502)1.96680053
101Increased CSF lactate (HP:0002490)1.96036876
102Aplastic anemia (HP:0001915)1.95569930
103Emphysema (HP:0002097)1.95517124
104Broad-based gait (HP:0002136)1.93909147
105Optic disc pallor (HP:0000543)1.92746657
106Ankyloglossia (HP:0010296)1.91679045
107Renal cortical cysts (HP:0000803)1.91478018
108Natal tooth (HP:0000695)1.91355149
109Optic neuritis (HP:0100653)1.90841672
110Retrobulbar optic neuritis (HP:0100654)1.90841672
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90687950
112Abnormal protein N-linked glycosylation (HP:0012347)1.90687950
113Abnormal protein glycosylation (HP:0012346)1.90687950
114Abnormal glycosylation (HP:0012345)1.90687950
115Corneal dystrophy (HP:0001131)1.90245629
116Abnormality of the epiphyses of the hand (HP:0005924)1.90185296
117Vertebral arch anomaly (HP:0008438)1.88049489
118Dysmetric saccades (HP:0000641)1.87453921
119Congenital sensorineural hearing impairment (HP:0008527)1.87279030
120Pulmonary artery stenosis (HP:0004415)1.86786693
121Gaze-evoked nystagmus (HP:0000640)1.86575732
122Dyschromatopsia (HP:0007641)1.86440141
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.85926475
124Hypoplasia of the fovea (HP:0007750)1.85926475
125Delayed closure of the anterior fontanelle (HP:0001476)1.85645666
126Wrist flexion contracture (HP:0001239)1.84636903
127Fibular hypoplasia (HP:0003038)1.84563511
128Abnormal glucose tolerance (HP:0001952)1.83610574
129Limited hip movement (HP:0008800)1.83321827
130Spinal canal stenosis (HP:0003416)1.82570224
131Abnormality of the acetabulum (HP:0003170)1.82215645
132Fetal akinesia sequence (HP:0001989)1.81313979
133Abnormality of oral frenula (HP:0000190)1.81271066
134Hypoplasia of the iris (HP:0007676)1.81196760
135Narrow nasal bridge (HP:0000446)1.80596451
136Genital tract atresia (HP:0001827)1.80000966
137Mitral valve prolapse (HP:0001634)1.79652734
138Knee flexion contracture (HP:0006380)1.79114985
139Optic nerve hypoplasia (HP:0000609)1.78671770
140Heterochromia iridis (HP:0001100)1.78381830
141Menstrual irregularities (HP:0000858)1.78288235
142Increased variability in muscle fiber diameter (HP:0003557)1.78102402
143Onycholysis (HP:0001806)1.77940298
144Heterotopia (HP:0002282)1.76649553
145Cubitus valgus (HP:0002967)1.76038611
146Hydroxyprolinuria (HP:0003080)1.75785117
147Abnormality of proline metabolism (HP:0010907)1.75785117
148Subacute progressive viral hepatitis (HP:0006572)1.75695646
149Broad metatarsal (HP:0001783)1.74163353
150Hepatocellular necrosis (HP:0001404)1.73844549
151Elbow flexion contracture (HP:0002987)1.73700286
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73566489
153Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.73483957
154IgA deficiency (HP:0002720)1.72620021
155Failure to thrive in infancy (HP:0001531)1.72398649
156Alopecia of scalp (HP:0002293)1.72257306
157Vaginal atresia (HP:0000148)1.72003814
158Blue sclerae (HP:0000592)1.71552038
159Pheochromocytoma (HP:0002666)1.70801346
160Abnormality of renal resorption (HP:0011038)1.70674292
161Barrel-shaped chest (HP:0001552)1.70466108
162Abnormality of dental color (HP:0011073)1.70450882
163Hypokalemic alkalosis (HP:0001949)1.70228380
164Slender build (HP:0001533)1.69790669
165Renal tubular dysfunction (HP:0000124)1.69180852
166Agammaglobulinemia (HP:0004432)1.69149801
167Abnormality of the femoral head (HP:0003368)1.68236146
168Vitreoretinal degeneration (HP:0000655)1.68099184
169Ovoid vertebral bodies (HP:0003300)1.67571393
170Short femoral neck (HP:0100864)1.67388661
171Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.67282015
172Abnormality of the intrinsic pathway (HP:0010989)1.67168721
173Bundle branch block (HP:0011710)1.66974242
174Muscle fiber atrophy (HP:0100295)1.65898166
175Tibial bowing (HP:0002982)1.65744837
176Broad face (HP:0000283)1.65597444
177Long foot (HP:0001833)1.65558788
178Short nail (HP:0001799)1.65471150
179Curly hair (HP:0002212)1.65369804
180Bilateral sensorineural hearing impairment (HP:0008619)1.65358524
181Progressive cerebellar ataxia (HP:0002073)1.64494731
182Hoarse voice (HP:0001609)1.64265705
183Hyperextensible skin (HP:0000974)1.63150726
184Abnormality of skeletal muscle fiber size (HP:0012084)1.63128530
185Lip pit (HP:0100267)1.62457373
186Thyroid-stimulating hormone excess (HP:0002925)1.62138043
187Metaphyseal dysplasia (HP:0100255)1.62047357
188Asymmetric septal hypertrophy (HP:0001670)1.61277321
189Decreased circulating renin level (HP:0003351)1.61123128
190Increased density of long bones (HP:0006392)1.60179167
191Milia (HP:0001056)1.59177899
192Limb-girdle muscle weakness (HP:0003325)1.59099719
193Advanced eruption of teeth (HP:0006288)1.58430022
194Right ventricular cardiomyopathy (HP:0011663)1.57882750
195Hyperactive renin-angiotensin system (HP:0000841)1.56117346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.29023073
2PRPF4B3.80587038
3MAP3K123.01650736
4MST1R2.77947793
5AKT32.75467705
6MKNK22.66316931
7SIK32.61307431
8TTN2.59817505
9PDGFRA2.59435997
10SGK22.34650686
11FRK2.24119346
12MAP3K142.20711904
13BMPR22.19234489
14PTK22.16468571
15MET2.05181277
16RIPK12.05123845
17MAP2K72.03219677
18BRD41.99006256
19JAK11.97258494
20ZAK1.83403457
21DDR21.80935878
22STK241.79927733
23MAP3K91.74366632
24LATS11.72157991
25ERN11.69208673
26ERBB31.65445447
27PLK21.64582427
28CCNB11.63062313
29MUSK1.62395450
30INSRR1.61477219
31MKNK11.60823648
32SGK2231.57372329
33SGK4941.57372329
34MYLK1.52779468
35TGFBR21.51058296
36STK381.49502729
37TIE11.48899437
38TNIK1.47705431
39BCR1.45161333
40TXK1.40013814
41PIK3CA1.38002428
42TSSK61.36815518
43YES11.32709861
44PDGFRB1.32025949
45CDK81.30085526
46MST41.29860364
47SGK31.29574551
48BMPR1B1.29522634
49TRPM71.27178084
50MAPK131.22893637
51LATS21.21943374
52MELK1.20903057
53CDK191.18019337
54NEK61.16944463
55TEC1.16283185
56MOS1.16187942
57STK161.12718650
58STK38L1.12336367
59TAOK31.11254830
60ROCK21.10590592
61STK31.09704278
62PIK3CG1.07448019
63PAK21.05007539
64NTRK11.03898989
65IRAK40.99723993
66CDC42BPA0.97875194
67IRAK20.97001052
68MAPK110.96504983
69LMTK20.96374453
70ADRBK20.94175114
71EPHA20.93446092
72OXSR10.91446225
73IRAK10.91063003
74SCYL20.90622918
75DMPK0.89806307
76PRKCE0.88973832
77GRK10.85705089
78MAP3K20.85454046
79MAP3K40.84989281
80MARK10.83133788
81CDK120.81639927
82ROCK10.80504114
83PAK30.78815938
84IRAK30.78739357
85ERBB40.78345674
86FGFR40.77745923
87DAPK10.76030380
88CDK30.74910083
89KSR20.71489439
90STK100.68976252
91MAP3K70.68618922
92MTOR0.68506503
93RPS6KB10.68385707
94CAMKK20.67474695
95NUAK10.66278917
96ARAF0.65877172
97MAPK70.65078945
98GRK70.64399662
99LIMK10.62246997
100PRKD20.61689495
101TYK20.60843540
102KIT0.60706332
103NEK90.59458331
104PDK20.59277679
105CLK10.59022151
106TNK20.58550096
107FLT30.58545632
108CHUK0.58445164
109IKBKB0.58362300
110EPHB10.57426919
111FGFR30.56965344
112WNK10.56740307
113MAP3K30.55384422
114FER0.55032424
115IKBKE0.53675096
116EPHA30.53083023
117PRKAA20.52465800
118NLK0.52375386
119EEF2K0.52298923
120MAP2K10.50379428
121PLK30.49532784
122PDPK10.49260553
123PHKG10.48944777
124PHKG20.48944777
125NTRK30.47146219
126MAPKAPK30.46367911
127EIF2AK30.46366229
128MAPKAPK50.45947878
129EIF2AK20.45905316
130SIK10.44982850
131PRKCH0.44831037
132CAMK2A0.44128863
133RPS6KA60.43897017
134RAF10.43845871
135PTK2B0.43273662
136TBK10.43161435
137PDK10.42678731
138ICK0.42365465
139SGK10.41868309
140CAMK2D0.41531216
141PRKG20.40937595
142GSK3A0.40574915
143PIM20.39659448
144ACVR1B0.39578330
145VRK10.39261666
146MAPK120.38176090
147MINK10.37688992
148NME10.37603779
149RPS6KL10.36831716
150RPS6KC10.36831716
151DYRK1A0.34136772
152CAMK2B0.33825581
153RPS6KA20.32480058
154OBSCN0.31476687
155MAP3K130.31200348
156CAMK40.31090094
157DAPK20.30844596
158ADRBK10.29253234
159MAP2K30.28507770
160PRKG10.27556047
161GRK50.27166200
162SYK0.26834621
163MATK0.24938032

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041302.72135561
2Collecting duct acid secretion_Homo sapiens_hsa049662.55759954
3Olfactory transduction_Homo sapiens_hsa047402.48763057
4Phototransduction_Homo sapiens_hsa047442.47885648
5Protein export_Homo sapiens_hsa030602.43494298
6Nicotine addiction_Homo sapiens_hsa050332.34046340
7Focal adhesion_Homo sapiens_hsa045102.25721642
8Rheumatoid arthritis_Homo sapiens_hsa053232.08547285
9Vibrio cholerae infection_Homo sapiens_hsa051102.04764823
10Synaptic vesicle cycle_Homo sapiens_hsa047212.04042198
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03677768
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98009434
13Taste transduction_Homo sapiens_hsa047421.84179332
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.84051381
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75115249
16Morphine addiction_Homo sapiens_hsa050321.74533499
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68437797
18Serotonergic synapse_Homo sapiens_hsa047261.67608402
19Circadian entrainment_Homo sapiens_hsa047131.59835904
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59202259
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54683956
22Oxidative phosphorylation_Homo sapiens_hsa001901.54236458
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53304563
24Small cell lung cancer_Homo sapiens_hsa052221.43842644
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43261638
26Proteoglycans in cancer_Homo sapiens_hsa052051.42649520
27Basal transcription factors_Homo sapiens_hsa030221.39512969
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38237593
29Dorso-ventral axis formation_Homo sapiens_hsa043201.35879715
30Phagosome_Homo sapiens_hsa041451.33730832
31Adherens junction_Homo sapiens_hsa045201.27903385
32Amphetamine addiction_Homo sapiens_hsa050311.22285652
33Renal cell carcinoma_Homo sapiens_hsa052111.22052489
34GABAergic synapse_Homo sapiens_hsa047271.21087756
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.18193996
36Autoimmune thyroid disease_Homo sapiens_hsa053201.17364638
37TNF signaling pathway_Homo sapiens_hsa046681.17337721
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17257051
39Glioma_Homo sapiens_hsa052141.16125177
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15750280
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15035941
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11500610
43Dopaminergic synapse_Homo sapiens_hsa047281.10745677
44Insulin secretion_Homo sapiens_hsa049111.08825554
45Non-homologous end-joining_Homo sapiens_hsa034501.06632940
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05177244
47Sphingolipid metabolism_Homo sapiens_hsa006001.05008287
48Long-term potentiation_Homo sapiens_hsa047201.04623341
49mTOR signaling pathway_Homo sapiens_hsa041501.04006064
50Pancreatic cancer_Homo sapiens_hsa052121.01983472
51Glutamatergic synapse_Homo sapiens_hsa047241.01763147
52Amoebiasis_Homo sapiens_hsa051460.99033011
53Calcium signaling pathway_Homo sapiens_hsa040200.98356172
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97491469
55Protein digestion and absorption_Homo sapiens_hsa049740.97023275
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95683468
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94491244
58Allograft rejection_Homo sapiens_hsa053300.93225989
59Long-term depression_Homo sapiens_hsa047300.93166465
60Circadian rhythm_Homo sapiens_hsa047100.92835925
61Toxoplasmosis_Homo sapiens_hsa051450.92835047
62Thyroid hormone synthesis_Homo sapiens_hsa049180.91480450
63GnRH signaling pathway_Homo sapiens_hsa049120.91287318
64Melanoma_Homo sapiens_hsa052180.90724395
65Estrogen signaling pathway_Homo sapiens_hsa049150.90562186
66Arachidonic acid metabolism_Homo sapiens_hsa005900.90483176
67Parkinsons disease_Homo sapiens_hsa050120.89837376
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89770507
69Insulin resistance_Homo sapiens_hsa049310.89497959
70Hematopoietic cell lineage_Homo sapiens_hsa046400.89288532
71Prolactin signaling pathway_Homo sapiens_hsa049170.87101508
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86755231
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86161146
74Chronic myeloid leukemia_Homo sapiens_hsa052200.84790924
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.84306015
76Cholinergic synapse_Homo sapiens_hsa047250.83809731
77Complement and coagulation cascades_Homo sapiens_hsa046100.82932533
78Platelet activation_Homo sapiens_hsa046110.81473609
79Renin secretion_Homo sapiens_hsa049240.81422855
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81337327
81Non-small cell lung cancer_Homo sapiens_hsa052230.81290190
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.79071318
83Alzheimers disease_Homo sapiens_hsa050100.78953449
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.78742424
85B cell receptor signaling pathway_Homo sapiens_hsa046620.78292388
86FoxO signaling pathway_Homo sapiens_hsa040680.76851577
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.76633447
88MicroRNAs in cancer_Homo sapiens_hsa052060.76430622
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.75842163
90Ras signaling pathway_Homo sapiens_hsa040140.75413341
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73693530
92Influenza A_Homo sapiens_hsa051640.73282974
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73251948
94Fatty acid elongation_Homo sapiens_hsa000620.73101266
95Type I diabetes mellitus_Homo sapiens_hsa049400.72460000
96African trypanosomiasis_Homo sapiens_hsa051430.72134181
97cAMP signaling pathway_Homo sapiens_hsa040240.71606091
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.71314223
99Viral myocarditis_Homo sapiens_hsa054160.71243009
100Hepatitis B_Homo sapiens_hsa051610.71143082
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70689703
102Gap junction_Homo sapiens_hsa045400.70291489
103Endometrial cancer_Homo sapiens_hsa052130.69583433
104Measles_Homo sapiens_hsa051620.69526003
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.69449072
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69043390
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68846933
108Sulfur metabolism_Homo sapiens_hsa009200.68393613
109Huntingtons disease_Homo sapiens_hsa050160.68276899
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67985626
111Endocytosis_Homo sapiens_hsa041440.67536598
112ECM-receptor interaction_Homo sapiens_hsa045120.66790535
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66472381
114Dilated cardiomyopathy_Homo sapiens_hsa054140.65859360
115Bladder cancer_Homo sapiens_hsa052190.64805146
116Ovarian steroidogenesis_Homo sapiens_hsa049130.64749160
117TGF-beta signaling pathway_Homo sapiens_hsa043500.64059857
118Apoptosis_Homo sapiens_hsa042100.63986801
119Caffeine metabolism_Homo sapiens_hsa002320.63076049
120Prion diseases_Homo sapiens_hsa050200.62934879
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62328164
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61932775
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61617359
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61114605
125N-Glycan biosynthesis_Homo sapiens_hsa005100.60972295
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60805098
127Choline metabolism in cancer_Homo sapiens_hsa052310.59932033
128Salivary secretion_Homo sapiens_hsa049700.59629527
129Rap1 signaling pathway_Homo sapiens_hsa040150.59357550
130ABC transporters_Homo sapiens_hsa020100.59169236
131MAPK signaling pathway_Homo sapiens_hsa040100.58892421
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.58732132
133Pancreatic secretion_Homo sapiens_hsa049720.58601149
134Primary immunodeficiency_Homo sapiens_hsa053400.58573138
135Legionellosis_Homo sapiens_hsa051340.58062206
136Cocaine addiction_Homo sapiens_hsa050300.57902774
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57041236
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.56572138
139Oxytocin signaling pathway_Homo sapiens_hsa049210.56436063
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55967101
141Insulin signaling pathway_Homo sapiens_hsa049100.55491926
142Inositol phosphate metabolism_Homo sapiens_hsa005620.55439380
143Renin-angiotensin system_Homo sapiens_hsa046140.55335503
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55107285
145Tight junction_Homo sapiens_hsa045300.55015382
146Pathways in cancer_Homo sapiens_hsa052000.54772017
147Type II diabetes mellitus_Homo sapiens_hsa049300.54448521
148RNA degradation_Homo sapiens_hsa030180.53607069
149Glucagon signaling pathway_Homo sapiens_hsa049220.53589632
150ErbB signaling pathway_Homo sapiens_hsa040120.53231232
151HIF-1 signaling pathway_Homo sapiens_hsa040660.53022625
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50946680
153Thyroid cancer_Homo sapiens_hsa052160.50823675
154AMPK signaling pathway_Homo sapiens_hsa041520.50531187
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50500714
156Graft-versus-host disease_Homo sapiens_hsa053320.50203767
157Other glycan degradation_Homo sapiens_hsa005110.49130644
158Malaria_Homo sapiens_hsa051440.48347915
159Gastric acid secretion_Homo sapiens_hsa049710.47025594
160Regulation of autophagy_Homo sapiens_hsa041400.46642346
161Purine metabolism_Homo sapiens_hsa002300.45074421
162Melanogenesis_Homo sapiens_hsa049160.44272301
163Prostate cancer_Homo sapiens_hsa052150.44011758
164Chemokine signaling pathway_Homo sapiens_hsa040620.43354401
165Hepatitis C_Homo sapiens_hsa051600.42920016
166Fanconi anemia pathway_Homo sapiens_hsa034600.42095436
167NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41139578
168Galactose metabolism_Homo sapiens_hsa000520.40052798

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »