ZBTB41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic retina morphogenesis in camera-type eye (GO:0060059)4.36093806
2cytoplasmic mRNA processing body assembly (GO:0033962)3.98335817
3presynaptic membrane assembly (GO:0097105)3.98230501
4pyrimidine nucleobase catabolic process (GO:0006208)3.78301631
5presynaptic membrane organization (GO:0097090)3.70008457
6hippo signaling (GO:0035329)3.61414503
7mitotic sister chromatid cohesion (GO:0007064)3.61014235
8insulin-like growth factor receptor signaling pathway (GO:0048009)3.51011839
9establishment of nucleus localization (GO:0040023)3.25006756
10neural tube formation (GO:0001841)3.22629218
11regulation of RNA export from nucleus (GO:0046831)3.07824192
12central nervous system neuron axonogenesis (GO:0021955)3.03113782
13positive regulation of fatty acid beta-oxidation (GO:0032000)2.96945198
14central nervous system projection neuron axonogenesis (GO:0021952)2.96502276
15dorsal/ventral axis specification (GO:0009950)2.94806927
16nucleobase catabolic process (GO:0046113)2.94688686
17neuron recognition (GO:0008038)2.94121971
18negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90629762
19midgut development (GO:0007494)2.89346214
20neurotransmitter-gated ion channel clustering (GO:0072578)2.88686882
21nucleus localization (GO:0051647)2.87581298
22axon extension involved in axon guidance (GO:0048846)2.87554308
23neuron projection extension involved in neuron projection guidance (GO:1902284)2.87554308
24gastrulation with mouth forming second (GO:0001702)2.85001886
25calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84474533
26metanephric mesenchyme development (GO:0072075)2.84097093
27glutamate secretion (GO:0014047)2.83729381
28establishment of protein localization to Golgi (GO:0072600)2.82901564
29keratinocyte development (GO:0003334)2.80801866
30Golgi to endosome transport (GO:0006895)2.79946712
31positive regulation of glycogen biosynthetic process (GO:0045725)2.78258541
32layer formation in cerebral cortex (GO:0021819)2.77698043
33synapse assembly (GO:0007416)2.77416226
34dendrite morphogenesis (GO:0048813)2.77347610
35Golgi transport vesicle coating (GO:0048200)2.75644836
36COPI coating of Golgi vesicle (GO:0048205)2.75644836
37ectodermal placode formation (GO:0060788)2.75530543
38neuron cell-cell adhesion (GO:0007158)2.75366050
39axon extension (GO:0048675)2.74819426
40cerebral cortex radially oriented cell migration (GO:0021799)2.74794689
41limb bud formation (GO:0060174)2.73764632
42cell migration involved in sprouting angiogenesis (GO:0002042)2.73491121
43protein K11-linked deubiquitination (GO:0035871)2.72958343
44positive regulation of glycolytic process (GO:0045821)2.71685687
45stress granule assembly (GO:0034063)2.70812975
46cell adhesion mediated by integrin (GO:0033627)2.70482510
47chondrocyte development (GO:0002063)2.69275596
48protein localization to cilium (GO:0061512)2.66470570
49collagen fibril organization (GO:0030199)2.65369871
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65288256
51cellular ketone body metabolic process (GO:0046950)2.64734059
52retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64497069
53ketone body metabolic process (GO:1902224)2.64289905
54regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.63273692
55embryonic viscerocranium morphogenesis (GO:0048703)2.62871626
56postsynaptic membrane organization (GO:0001941)2.61046358
57dendritic spine morphogenesis (GO:0060997)2.60216611
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59979081
59iron ion import (GO:0097286)2.59738497
60protein localization to endosome (GO:0036010)2.57029371
61regulation of cell communication by electrical coupling (GO:0010649)2.55279809
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54897068
63detection of calcium ion (GO:0005513)2.54264255
64retinal ganglion cell axon guidance (GO:0031290)2.54022447
65nuclear pore complex assembly (GO:0051292)2.53950214
66regulation of fatty acid beta-oxidation (GO:0031998)2.52039686
67interkinetic nuclear migration (GO:0022027)2.51713627
68negative regulation of dendrite development (GO:2000171)2.51488612
69regulation of nucleobase-containing compound transport (GO:0032239)2.51112660
70dopamine biosynthetic process (GO:0042416)2.50449442
71growth hormone receptor signaling pathway (GO:0060396)2.50366216
72positive regulation of protein autophosphorylation (GO:0031954)2.50339117
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.48803964
74positive regulation of macroautophagy (GO:0016239)2.48770827
75regulation of Rac protein signal transduction (GO:0035020)2.48545943
76intra-Golgi vesicle-mediated transport (GO:0006891)2.47277531
77regulation of DNA endoreduplication (GO:0032875)2.47189607
78negative regulation of catenin import into nucleus (GO:0035414)2.46162052
79cerebral cortex cell migration (GO:0021795)2.46161918
80glycosphingolipid biosynthetic process (GO:0006688)2.45516022
81intraciliary transport (GO:0042073)2.44749313
82camera-type eye morphogenesis (GO:0048593)2.44739063
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44628623
84anatomical structure arrangement (GO:0048532)2.44126729
85lysine catabolic process (GO:0006554)2.43859600
86lysine metabolic process (GO:0006553)2.43859600
87kidney mesenchyme development (GO:0072074)2.43468013
88positive regulation of mitochondrial fission (GO:0090141)2.42270977
89nonmotile primary cilium assembly (GO:0035058)2.40667875
90microtubule anchoring (GO:0034453)2.39332978
91regulation of cAMP-dependent protein kinase activity (GO:2000479)2.39210309
92regulation of glucokinase activity (GO:0033131)2.38971411
93regulation of hexokinase activity (GO:1903299)2.38971411
94protein localization to synapse (GO:0035418)2.38513483
95macroautophagy (GO:0016236)2.38430754
96synaptic vesicle maturation (GO:0016188)2.38137219
97regulation of protein glycosylation (GO:0060049)2.37837357
98regulation of axon guidance (GO:1902667)2.36312991
99magnesium ion transport (GO:0015693)2.36073703
100peptidyl-cysteine modification (GO:0018198)2.35731871
101peptidyl-lysine dimethylation (GO:0018027)2.34123322
102prostate gland growth (GO:0060736)2.33700221
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33613999
104righting reflex (GO:0060013)2.33397193
105positive regulation of glycogen metabolic process (GO:0070875)2.33017137
106regulation of catenin import into nucleus (GO:0035412)2.32758466
107cilium morphogenesis (GO:0060271)2.32743148
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32680502
109protein localization to Golgi apparatus (GO:0034067)2.32465031
110germ cell migration (GO:0008354)2.32204204
111cilium assembly (GO:0042384)2.31835528
112negative regulation of fatty acid transport (GO:2000192)2.31331237
113regulation of clathrin-mediated endocytosis (GO:2000369)2.31175388
114regulation of axon extension involved in axon guidance (GO:0048841)2.30760009
115vascular smooth muscle contraction (GO:0014829)2.30120895
116glial cell proliferation (GO:0014009)2.29812738
117proline transport (GO:0015824)2.29794176
118regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.29681812
119cellular response to vitamin D (GO:0071305)2.27840477
120insulin secretion (GO:0030073)2.27313164
121regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27221560
122inositol phosphate catabolic process (GO:0071545)2.27098327
123retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26959234
124regulation of respiratory system process (GO:0044065)2.26704273
125startle response (GO:0001964)2.26518330
126regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26444856
127cilium organization (GO:0044782)2.25738018
128establishment of melanosome localization (GO:0032401)2.24747027
129positive regulation of fatty acid oxidation (GO:0046321)2.24638217
130chondrocyte proliferation (GO:0035988)2.24114935
131genitalia morphogenesis (GO:0035112)2.23949502
132NLS-bearing protein import into nucleus (GO:0006607)2.23633582
133neurotransmitter secretion (GO:0007269)2.23425575
134vesicle transport along microtubule (GO:0047496)2.23169994
135regulation of sister chromatid cohesion (GO:0007063)2.22722462
136COPII vesicle coating (GO:0048208)2.21836402
137neuron projection extension (GO:1990138)2.20938222
138regulation of mesenchymal cell proliferation (GO:0010464)2.20150410
139organelle transport along microtubule (GO:0072384)2.20140615
140vesicle localization (GO:0051648)2.19615420
141melanosome transport (GO:0032402)2.19168031
142ganglion development (GO:0061548)2.18784244
143negative regulation of vascular permeability (GO:0043116)2.18357769
144neuron maturation (GO:0042551)2.17911423
145glutamate receptor signaling pathway (GO:0007215)2.17871806
146protein localization to cell surface (GO:0034394)2.17817920
147synapse organization (GO:0050808)2.17758454
148regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.17459536
149regulation of synapse assembly (GO:0051963)2.17293942
150eye photoreceptor cell differentiation (GO:0001754)2.16530460
151photoreceptor cell differentiation (GO:0046530)2.16530460
152negative regulation of keratinocyte proliferation (GO:0010839)2.15960651
153metanephric nephron tubule development (GO:0072234)2.15334074
154metanephric tubule development (GO:0072170)2.15334074
155morphogenesis of an epithelial sheet (GO:0002011)2.15169840
156cellular response to vitamin (GO:0071295)2.14972162
157nuclear pore organization (GO:0006999)2.14957163
158microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.13902921
159neuron-neuron synaptic transmission (GO:0007270)2.13717193
160atrial cardiac muscle cell action potential (GO:0086014)2.13610823
161cellular response to cholesterol (GO:0071397)2.13405759
162negative regulation of neurotransmitter transport (GO:0051589)2.13394222
163positive regulation of mesenchymal cell proliferation (GO:0002053)2.13355950
164neuronal action potential (GO:0019228)2.13046227
165nerve growth factor signaling pathway (GO:0038180)2.12964430
166cellular response to growth hormone stimulus (GO:0071378)2.12633582
167regulation of dendritic spine development (GO:0060998)2.12136360
168plasma membrane repair (GO:0001778)2.12087998
169glycoprotein catabolic process (GO:0006516)2.12046086
170semaphorin-plexin signaling pathway (GO:0071526)2.11316006
171endoplasmic reticulum organization (GO:0007029)2.10950847
172asymmetric protein localization (GO:0008105)2.10835045
173auditory behavior (GO:0031223)2.10832128
174establishment of pigment granule localization (GO:0051905)2.10515401
175embryonic camera-type eye morphogenesis (GO:0048596)2.10510463
176synaptic vesicle docking involved in exocytosis (GO:0016081)2.10426760
177regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.09846706
178regulation of synaptic vesicle exocytosis (GO:2000300)2.09608129
179axonal fasciculation (GO:0007413)2.09237479
180protein targeting to Golgi (GO:0000042)2.08289713
181positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.07944211
182apical protein localization (GO:0045176)2.07696528
183monoubiquitinated protein deubiquitination (GO:0035520)2.07111054
184vesicle coating (GO:0006901)2.06895040
185regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.06799527
186regulation of heart morphogenesis (GO:2000826)2.06496715
187protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.06306070
188artery development (GO:0060840)2.05137231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.36016868
2* SALL1_21062744_ChIP-ChIP_HESCs_Human3.17137279
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02887320
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90839016
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87875095
6IGF1R_20145208_ChIP-Seq_DFB_Human2.55757982
7CLOCK_20551151_ChIP-Seq_293T_Human2.24679485
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.15446245
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.09649119
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06296358
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05739508
12GBX2_23144817_ChIP-Seq_PC3_Human2.02603685
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94699140
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92943396
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91696238
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.84790667
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84377175
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83501272
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80591567
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.79329954
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79182939
22TP53_16413492_ChIP-PET_HCT116_Human1.73624176
23* NANOG_18555785_Chip-Seq_ESCs_Mouse1.73179422
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.66140341
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64100378
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62233183
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55516140
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.54940118
29ZNF274_21170338_ChIP-Seq_K562_Hela1.53845313
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53113429
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53001407
32FUS_26573619_Chip-Seq_HEK293_Human1.52526032
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51592308
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51524805
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51009285
36VDR_22108803_ChIP-Seq_LS180_Human1.50328522
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49391319
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48884308
39* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48466911
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47942752
41AR_21572438_ChIP-Seq_LNCaP_Human1.45515551
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.44895543
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43696028
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43596653
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43332152
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42554857
47* P53_22387025_ChIP-Seq_ESCs_Mouse1.42307253
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41769520
49* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40787596
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.40742709
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40733138
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40733138
53* E2F1_18555785_Chip-Seq_ESCs_Mouse1.40581114
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.38933416
55CJUN_26792858_Chip-Seq_BT549_Human1.38167420
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.37276592
57SMAD4_21799915_ChIP-Seq_A2780_Human1.37198713
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.37024944
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36066420
60BRD4_25478319_ChIP-Seq_HGPS_Human1.36038897
61STAT3_23295773_ChIP-Seq_U87_Human1.35721456
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35390850
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35192372
64* CMYC_18555785_Chip-Seq_ESCs_Mouse1.34975198
65BCAT_22108803_ChIP-Seq_LS180_Human1.34547931
66CBP_20019798_ChIP-Seq_JUKART_Human1.33677399
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33677399
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.33573676
69* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32566753
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.31308616
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30519304
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30262333
73AHR_22903824_ChIP-Seq_MCF-7_Human1.29834386
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.29249260
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27732868
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27377523
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27021172
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.26718389
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26197303
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26130399
81TP53_18474530_ChIP-ChIP_U2OS_Human1.24258000
82P300_19829295_ChIP-Seq_ESCs_Human1.23466884
83GATA1_22025678_ChIP-Seq_K562_Human1.21288243
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18789064
85* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18776490
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18256214
87* SOX2_18555785_Chip-Seq_ESCs_Mouse1.18015757
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17748512
89* P300_18555785_Chip-Seq_ESCs_Mouse1.17441207
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17413348
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17291787
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16319740
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15782408
94* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15735760
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15573046
96RUNX2_22187159_ChIP-Seq_PCA_Human1.15491614
97RNF2_27304074_Chip-Seq_NSC_Mouse1.15196289
98EWS_26573619_Chip-Seq_HEK293_Human1.15162855
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14892953
100* STAT3_18555785_Chip-Seq_ESCs_Mouse1.14748454
101TCF4_22108803_ChIP-Seq_LS180_Human1.13723875
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13433032
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13426424
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.12910146
105ER_23166858_ChIP-Seq_MCF-7_Human1.11289958
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.11249402
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10720447
108AR_19668381_ChIP-Seq_PC3_Human1.10344186
109AR_25329375_ChIP-Seq_VCAP_Human1.10190698
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10136274
111* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10105567
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.10073034
113* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09616382
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09317905
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.07682509
116* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07653974
117TAF15_26573619_Chip-Seq_HEK293_Human1.07621701
118ZNF263_19887448_ChIP-Seq_K562_Human1.07483389
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07201905
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06207462
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05681755
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05622979
123* CDX2_22108803_ChIP-Seq_LS180_Human1.05396367
124TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05175172
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.04983116
126JUN_21703547_ChIP-Seq_K562_Human1.04920049
127TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04784279
128SOX9_26525672_Chip-Seq_HEART_Mouse1.04744156
129PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04513951
130REST_21632747_ChIP-Seq_MESCs_Mouse1.03508625
131* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03395984
132RXR_22108803_ChIP-Seq_LS180_Human1.02327311
133LXR_22158963_ChIP-Seq_LIVER_Mouse1.02308991
134EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02080038
135RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02080038
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01311196
137* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00533906
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00493901
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00313627
140TCF4_23295773_ChIP-Seq_U87_Human1.00229065
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97136605
142EZH2_27304074_Chip-Seq_ESCs_Mouse0.96532620
143* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94478940
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93862217
145EZH2_22144423_ChIP-Seq_EOC_Human0.93835513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.51990378
2MP0003880_abnormal_central_pattern3.18610473
3MP0004270_analgesia3.04696375
4MP0009780_abnormal_chondrocyte_physiolo3.01650209
5MP0003705_abnormal_hypodermis_morpholog2.94404236
6MP0000569_abnormal_digit_pigmentation2.91452458
7MP0002877_abnormal_melanocyte_morpholog2.87437433
8MP0001299_abnormal_eye_distance/2.62189156
9MP0010234_abnormal_vibrissa_follicle2.54398749
10MP0003300_gastrointestinal_ulcer2.31218895
11MP0009046_muscle_twitch2.05406775
12MP0009384_cardiac_valve_regurgitation2.03159245
13MP0006072_abnormal_retinal_apoptosis2.00300295
14MP0005187_abnormal_penis_morphology2.00095456
15MP0005503_abnormal_tendon_morphology1.99196003
16MP0008057_abnormal_DNA_replication1.96803695
17MP0005623_abnormal_meninges_morphology1.96100872
18MP0010352_gastrointestinal_tract_polyps1.95798784
19MP0002009_preneoplasia1.93450203
20MP0001984_abnormal_olfaction1.93076979
21MP0005275_abnormal_skin_tensile1.92895728
22MP0005248_abnormal_Harderian_gland1.89521565
23MP0000537_abnormal_urethra_morphology1.87739408
24MP0003252_abnormal_bile_duct1.86786684
25MP0002139_abnormal_hepatobiliary_system1.75209249
26MP0003283_abnormal_digestive_organ1.70912952
27MP0003937_abnormal_limbs/digits/tail_de1.67914845
28MP0001529_abnormal_vocalization1.65212349
29MP0005253_abnormal_eye_physiology1.62137287
30MP0005220_abnormal_exocrine_pancreas1.62128896
31MP0002896_abnormal_bone_mineralization1.62125089
32MP0004272_abnormal_basement_membrane1.60449281
33MP0002102_abnormal_ear_morphology1.60169760
34MP0005645_abnormal_hypothalamus_physiol1.54808229
35MP0002184_abnormal_innervation1.53358164
36MP0003890_abnormal_embryonic-extraembry1.53288968
37MP0003635_abnormal_synaptic_transmissio1.52486417
38MP0004924_abnormal_behavior1.50714497
39MP0005386_behavior/neurological_phenoty1.50714497
40MP0002734_abnormal_mechanical_nocicepti1.50628678
41MP0000733_abnormal_muscle_development1.48848999
42MP0005379_endocrine/exocrine_gland_phen1.48780736
43MP0006276_abnormal_autonomic_nervous1.48444713
44MP0001486_abnormal_startle_reflex1.47643349
45MP0000013_abnormal_adipose_tissue1.46911345
46MP0009053_abnormal_anal_canal1.46629023
47MP0010368_abnormal_lymphatic_system1.43444364
48MP0005076_abnormal_cell_differentiation1.42615955
49MP0002272_abnormal_nervous_system1.42050043
50MP0003787_abnormal_imprinting1.41654183
51MP0009745_abnormal_behavioral_response1.41545663
52MP0003121_genomic_imprinting1.41505556
53MP0005423_abnormal_somatic_nervous1.41135797
54MP0010030_abnormal_orbit_morphology1.39126928
55MP0005408_hypopigmentation1.37696706
56MP0003935_abnormal_craniofacial_develop1.36628945
57MP0004134_abnormal_chest_morphology1.36089930
58MP0000428_abnormal_craniofacial_morphol1.33276177
59MP0002822_catalepsy1.33030241
60MP0004859_abnormal_synaptic_plasticity1.32695355
61MP0005360_urolithiasis1.32220469
62MP0002751_abnormal_autonomic_nervous1.30168558
63MP0002063_abnormal_learning/memory/cond1.29035288
64MP0002572_abnormal_emotion/affect_behav1.28965585
65MP0003385_abnormal_body_wall1.28893852
66MP0005551_abnormal_eye_electrophysiolog1.28580489
67MP0010678_abnormal_skin_adnexa1.26594281
68MP0000003_abnormal_adipose_tissue1.26560834
69MP0004185_abnormal_adipocyte_glucose1.26276800
70MP0003115_abnormal_respiratory_system1.25965003
71MP0004130_abnormal_muscle_cell1.25473908
72MP0002638_abnormal_pupillary_reflex1.24976440
73MP0002064_seizures1.24406627
74MP0000534_abnormal_ureter_morphology1.23888700
75MP0005365_abnormal_bile_salt1.23302424
76MP0009250_abnormal_appendicular_skeleto1.23134291
77MP0003868_abnormal_feces_composition1.22983893
78MP0003755_abnormal_palate_morphology1.22825804
79MP0008877_abnormal_DNA_methylation1.21497837
80MP0004264_abnormal_extraembryonic_tissu1.21038986
81MP0002557_abnormal_social/conspecific_i1.20874751
82MP0008789_abnormal_olfactory_epithelium1.20198629
83MP0005666_abnormal_adipose_tissue1.20085702
84MP0003045_fibrosis1.19296656
85MP0003942_abnormal_urinary_system1.19253897
86MP0000778_abnormal_nervous_system1.17751812
87MP0006054_spinal_hemorrhage1.16788841
88MP0001346_abnormal_lacrimal_gland1.15729519
89MP0003950_abnormal_plasma_membrane1.15544697
90MP0004811_abnormal_neuron_physiology1.14745023
91MP0004133_heterotaxia1.14332391
92MP0001879_abnormal_lymphatic_vessel1.14065431
93MP0002092_abnormal_eye_morphology1.13616044
94MP0003091_abnormal_cell_migration1.12797479
95MP0002168_other_aberrant_phenotype1.12542321
96MP0000462_abnormal_digestive_system1.12043400
97MP0000383_abnormal_hair_follicle1.11724354
98MP0002108_abnormal_muscle_morphology1.10461908
99MP0002735_abnormal_chemical_nociception1.10452812
100MP0002697_abnormal_eye_size1.09662113
101MP0005394_taste/olfaction_phenotype1.07822148
102MP0005499_abnormal_olfactory_system1.07822148
103MP0010386_abnormal_urinary_bladder1.06867119
104MP0000647_abnormal_sebaceous_gland1.06027736
105MP0000955_abnormal_spinal_cord1.06027619
106MP0001944_abnormal_pancreas_morphology1.05963649
107MP0005171_absent_coat_pigmentation1.05849593
108MP0009703_decreased_birth_body1.05111508
109MP0005257_abnormal_intraocular_pressure1.05101357
110MP0004885_abnormal_endolymph1.04421703
111MP0000427_abnormal_hair_cycle1.04324682
112MP0001188_hyperpigmentation1.03329958
113MP0003633_abnormal_nervous_system1.02901834
114MP0002067_abnormal_sensory_capabilities1.01519206
115MP0002882_abnormal_neuron_morphology1.00099488
116MP0000432_abnormal_head_morphology0.99146304
117MP0005646_abnormal_pituitary_gland0.99130775
118MP0002837_dystrophic_cardiac_calcinosis0.98472870
119MP0004197_abnormal_fetal_growth/weight/0.96471411
120MP0005375_adipose_tissue_phenotype0.95302223
121MP0002233_abnormal_nose_morphology0.94881343
122MP0004043_abnormal_pH_regulation0.93433147
123MP0005367_renal/urinary_system_phenotyp0.92966826
124MP0000516_abnormal_urinary_system0.92966826
125MP0000163_abnormal_cartilage_morphology0.90456777
126MP0000639_abnormal_adrenal_gland0.89806252
127MP0001440_abnormal_grooming_behavior0.87804809
128MP0001968_abnormal_touch/_nociception0.85696970
129MP0003195_calcinosis0.85063907
130MP0005174_abnormal_tail_pigmentation0.84697297
131MP0001177_atelectasis0.84590976
132MP0001286_abnormal_eye_development0.84335321
133MP0002090_abnormal_vision0.84192001
134MP0001340_abnormal_eyelid_morphology0.83638842
135MP0009672_abnormal_birth_weight0.83221023
136MP0002282_abnormal_trachea_morphology0.81983017
137MP0000631_abnormal_neuroendocrine_gland0.81641738
138MP0002177_abnormal_outer_ear0.81411420
139MP0001970_abnormal_pain_threshold0.81387470
140MP0004215_abnormal_myocardial_fiber0.80915807
141MP0002116_abnormal_craniofacial_bone0.79770483
142MP0000015_abnormal_ear_pigmentation0.79575449
143MP0003567_abnormal_fetal_cardiomyocyte0.79113378
144MP0002752_abnormal_somatic_nervous0.78997502
145MP0002115_abnormal_skeleton_extremities0.78805941
146MP0002909_abnormal_adrenal_gland0.78600005
147MP0002084_abnormal_developmental_patter0.78154394
148MP0005508_abnormal_skeleton_morphology0.77951494
149MP0002876_abnormal_thyroid_physiology0.77802080
150MP0001661_extended_life_span0.77500301
151MP0004142_abnormal_muscle_tone0.77394390
152MP0001958_emphysema0.77084920
153MP0002060_abnormal_skin_morphology0.77046981
154MP0002928_abnormal_bile_duct0.75894672
155MP0002152_abnormal_brain_morphology0.75089951
156MP0004085_abnormal_heartbeat0.75003698
157MP0001501_abnormal_sleep_pattern0.74145015
158MP0003631_nervous_system_phenotype0.73750920
159MP0001849_ear_inflammation0.72660780
160MP0002932_abnormal_joint_morphology0.72301173
161MP0004484_altered_response_of0.71438854
162MP0002295_abnormal_pulmonary_circulatio0.71059036
163MP0005391_vision/eye_phenotype0.70863511
164MP0005195_abnormal_posterior_eye0.70331988
165MP0003861_abnormal_nervous_system0.70252161
166MP0002066_abnormal_motor_capabilities/c0.70247037
167MP0002234_abnormal_pharynx_morphology0.69931921
168MP0003122_maternal_imprinting0.69795271
169MP0010307_abnormal_tumor_latency0.69525938
170MP0000371_diluted_coat_color0.67622689
171MP0003123_paternal_imprinting0.67424154

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)3.74378302
2Subacute progressive viral hepatitis (HP:0006572)3.63821486
3Hyperventilation (HP:0002883)3.63589050
4Macroorchidism (HP:0000053)3.17250482
5Shallow orbits (HP:0000586)3.09066457
6Short 4th metacarpal (HP:0010044)2.94643122
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94643122
8Medial flaring of the eyebrow (HP:0010747)2.91757174
9Gait imbalance (HP:0002141)2.89748227
10Premature rupture of membranes (HP:0001788)2.87373299
11Intestinal atresia (HP:0011100)2.71238722
12Febrile seizures (HP:0002373)2.71197318
13Limb dystonia (HP:0002451)2.69226191
14Congenital primary aphakia (HP:0007707)2.65539099
15Thyroid carcinoma (HP:0002890)2.61951571
16Pheochromocytoma (HP:0002666)2.57814288
17Volvulus (HP:0002580)2.57348561
18Protrusio acetabuli (HP:0003179)2.53115302
19Cerebral aneurysm (HP:0004944)2.53081284
20Lymphangioma (HP:0100764)2.52983328
21Abnormality of the corticospinal tract (HP:0002492)2.51647367
22Nephrogenic diabetes insipidus (HP:0009806)2.50302558
23Termporal pattern (HP:0011008)2.49844596
24Insidious onset (HP:0003587)2.49844596
25Ankyloglossia (HP:0010296)2.47665408
26Abnormality of the 4th metacarpal (HP:0010012)2.45055466
27Papillary thyroid carcinoma (HP:0002895)2.45032119
28Overgrowth (HP:0001548)2.40667487
29Mitral valve prolapse (HP:0001634)2.40255664
30Hemiparesis (HP:0001269)2.40126228
31Hypothermia (HP:0002045)2.40026783
32Tubulointerstitial nephritis (HP:0001970)2.37625388
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36557520
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.36557520
35Cortical dysplasia (HP:0002539)2.36098014
36Genital tract atresia (HP:0001827)2.36016628
37Aortic aneurysm (HP:0004942)2.35795823
38Atonic seizures (HP:0010819)2.35461095
39Exostoses (HP:0100777)2.33811704
40Hepatoblastoma (HP:0002884)2.33772302
41Pancreatic fibrosis (HP:0100732)2.31170577
42Aortic dissection (HP:0002647)2.29351744
43Biliary tract neoplasm (HP:0100574)2.26706176
44Action tremor (HP:0002345)2.26435129
45EEG with generalized epileptiform discharges (HP:0011198)2.25114256
46Absent speech (HP:0001344)2.25094646
47Epileptiform EEG discharges (HP:0011182)2.24888783
48Back pain (HP:0003418)2.24577225
49Buphthalmos (HP:0000557)2.23281575
50Bowel diverticulosis (HP:0005222)2.22385642
51Focal seizures (HP:0007359)2.21105426
52Neuroendocrine neoplasm (HP:0100634)2.18524593
53Enlarged penis (HP:0000040)2.15321516
54Drooling (HP:0002307)2.14802306
55Excessive salivation (HP:0003781)2.14802306
56Hypsarrhythmia (HP:0002521)2.14289249
57Vaginal atresia (HP:0000148)2.14224355
58Bladder diverticulum (HP:0000015)2.14205892
59Ankle contracture (HP:0006466)2.13186533
60Aqueductal stenosis (HP:0002410)2.12648493
61Coronal craniosynostosis (HP:0004440)2.12610636
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.11325819
63True hermaphroditism (HP:0010459)2.11253573
64Poor coordination (HP:0002370)2.11111952
65Transitional cell carcinoma of the bladder (HP:0006740)2.11105555
66Pancreatic cysts (HP:0001737)2.10643480
67Broad-based gait (HP:0002136)2.10054306
68Focal motor seizures (HP:0011153)2.08683781
69Astrocytoma (HP:0009592)2.08085722
70Abnormality of the astrocytes (HP:0100707)2.08085722
71Hyperinsulinemic hypoglycemia (HP:0000825)2.07451515
72Nephronophthisis (HP:0000090)2.06296848
73Hypoglycemic coma (HP:0001325)2.05251931
74Dilatation of the ascending aorta (HP:0005111)2.04773018
75Heterotopia (HP:0002282)2.04206677
76Abnormality of the renal medulla (HP:0100957)2.03937984
77Soft skin (HP:0000977)2.03782010
78Congenital sensorineural hearing impairment (HP:0008527)2.03067425
79Delayed gross motor development (HP:0002194)2.02481711
80Short tibia (HP:0005736)2.00615866
81Fair hair (HP:0002286)1.99680256
82Muscular hypotonia of the trunk (HP:0008936)1.99660935
83Oligodactyly (hands) (HP:0001180)1.99658411
84Bladder neoplasm (HP:0009725)1.99637444
85Bladder carcinoma (HP:0002862)1.99637444
86Abnormality of the renal cortex (HP:0011035)1.98352649
87Hypochromic microcytic anemia (HP:0004840)1.96439163
88Abnormal biliary tract morphology (HP:0012440)1.96127406
89Abnormality of oral frenula (HP:0000190)1.95190224
90Epileptic encephalopathy (HP:0200134)1.93094409
91Labial hypoplasia (HP:0000066)1.92128901
92Hypoplastic labia majora (HP:0000059)1.91810851
93Infantile muscular hypotonia (HP:0008947)1.90363964
94Hyperglycemia (HP:0003074)1.89832443
95Ketoacidosis (HP:0001993)1.89826781
96Double outlet right ventricle (HP:0001719)1.89246327
97Congenital malformation of the right heart (HP:0011723)1.89246327
98Hypoplastic ischia (HP:0003175)1.89099647
99Abnormality of the ischium (HP:0003174)1.88871632
100Atrophic scars (HP:0001075)1.87896696
101Proximal tubulopathy (HP:0000114)1.86723164
102Abnormality of midbrain morphology (HP:0002418)1.86372153
103Molar tooth sign on MRI (HP:0002419)1.86372153
104Hepatocellular carcinoma (HP:0001402)1.86341807
105Impaired vibration sensation in the lower limbs (HP:0002166)1.85894369
106Hallux valgus (HP:0001822)1.85762047
107Cubitus valgus (HP:0002967)1.85086666
108Asymmetry of the thorax (HP:0001555)1.84903088
109Aneurysm (HP:0002617)1.84434248
110Renal cortical cysts (HP:0000803)1.83605371
111Broad ribs (HP:0000885)1.83372521
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83368170
113Renovascular hypertension (HP:0100817)1.82637973
114Fetal akinesia sequence (HP:0001989)1.82526821
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.80991158
116Deviation of the hallux (HP:0010051)1.80652766
117Narrow palate (HP:0000189)1.80401271
118Absent frontal sinuses (HP:0002688)1.79585153
119Specific learning disability (HP:0001328)1.79486013
120Thin bony cortex (HP:0002753)1.79374617
121Dialeptic seizures (HP:0011146)1.78949105
122Generalized hypopigmentation of hair (HP:0011358)1.78569451
123Neoplasm of the small intestine (HP:0100833)1.78086173
124Long toe (HP:0010511)1.77898634
125Broad metatarsal (HP:0001783)1.77277257
126Turricephaly (HP:0000262)1.77196503
127Truncal obesity (HP:0001956)1.76103761
128Progressive cerebellar ataxia (HP:0002073)1.75937201
129Fibrous tissue neoplasm (HP:0012316)1.75903072
130Hypoglycemic seizures (HP:0002173)1.75842450
131Arterial tortuosity (HP:0005116)1.74628021
132Curly hair (HP:0002212)1.74541596
133Deep venous thrombosis (HP:0002625)1.74240779
134Hypopigmentation of the fundus (HP:0007894)1.73936518
135Wormian bones (HP:0002645)1.73835217
136Thoracolumbar scoliosis (HP:0002944)1.73829935
137Blue irides (HP:0000635)1.73822682
138Abnormality of the labia majora (HP:0012881)1.73591030
139Tibial bowing (HP:0002982)1.73573220
140Agitation (HP:0000713)1.72503593
141Progressive inability to walk (HP:0002505)1.72402256
142Bell-shaped thorax (HP:0001591)1.72131512
143Tubular atrophy (HP:0000092)1.71924448
144Lissencephaly (HP:0001339)1.71755173
145Vascular tortuosity (HP:0004948)1.70841773
146Insulin-resistant diabetes mellitus (HP:0000831)1.70766654
147Obsessive-compulsive behavior (HP:0000722)1.70603030
148Elfin facies (HP:0004428)1.69844177
149Abnormality of vitamin B metabolism (HP:0004340)1.69324657
150Generalized tonic-clonic seizures (HP:0002069)1.69200248
151Gaze-evoked nystagmus (HP:0000640)1.68689570
152Chronic hepatic failure (HP:0100626)1.67943396
153Increased density of long bones (HP:0006392)1.67677548
154Midline defect of the nose (HP:0004122)1.67390821
155Akinesia (HP:0002304)1.66861890
156Absence seizures (HP:0002121)1.66394408
157Gastrointestinal carcinoma (HP:0002672)1.66220980
158Malignant gastrointestinal tract tumors (HP:0006749)1.66220980
159Exotropia (HP:0000577)1.66092506
160Postaxial hand polydactyly (HP:0001162)1.65286734
161Widely spaced teeth (HP:0000687)1.64646231
162Aplasia/Hypoplasia of the lens (HP:0008063)1.64073907
163Methylmalonic acidemia (HP:0002912)1.64071891
164Generalized myoclonic seizures (HP:0002123)1.63918560
165Wrist flexion contracture (HP:0001239)1.62208733
166Hypoplastic female external genitalia (HP:0012815)1.62198449
167Scapular winging (HP:0003691)1.62118843
168Abnormality of macular pigmentation (HP:0008002)1.61603837
169Fibroma (HP:0010614)1.61171748
170Polyphagia (HP:0002591)1.61136861
171Osteolytic defects of the hand bones (HP:0009699)1.60804094
172Osteolytic defects of the phalanges of the hand (HP:0009771)1.60804094
173Short foot (HP:0001773)1.60771419
174Gastrointestinal atresia (HP:0002589)1.60721477
175Rectal prolapse (HP:0002035)1.60678449
176Venous abnormality (HP:0002624)1.59331251
177Hyperextensible skin (HP:0000974)1.58493312
178Striae distensae (HP:0001065)1.57430894
179Spastic diplegia (HP:0001264)1.55053584
180Facial hemangioma (HP:0000329)1.55043277
181Genu recurvatum (HP:0002816)1.52690995
182Renal duplication (HP:0000075)1.51258164
183Venous insufficiency (HP:0005293)1.51231926
184Wide anterior fontanel (HP:0000260)1.50818842
185Overriding aorta (HP:0002623)1.50700781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.58026876
2FRK3.19861676
3MARK12.71120380
4FGFR22.61856142
5MAP4K22.59368815
6PDGFRA2.38673550
7SIK12.33903486
8TRIM282.31715835
9TNIK2.31080948
10DDR22.25854121
11ERBB31.86243324
12PRKD31.86186754
13TRIB31.80650720
14MAP3K121.79568551
15CAMK1D1.78104102
16STK31.74709778
17AKT31.71276573
18NUAK11.69397848
19WNK31.61734084
20PAK31.61423052
21MAP3K61.60443540
22TTN1.56219128
23MAP2K71.54835150
24LATS21.52708087
25RET1.50978890
26FGFR31.48230540
27KSR11.46718190
28PKN21.46332030
29EIF2AK31.45264737
30CAMK1G1.44406301
31EPHA41.44385708
32PINK11.42561754
33CDK61.42023175
34INSRR1.41510744
35STK391.40469250
36MAP3K21.37448174
37ERBB41.37272899
38STK241.30718294
39PTK61.26992703
40FGFR11.24368021
41CDC71.24281224
42MAP3K41.22571116
43PRKCE1.22249686
44DMPK1.20933387
45EPHB21.20386378
46PDGFRB1.17510131
47CCNB11.13975183
48CAMKK21.13671064
49PAK61.11058836
50EPHA31.09947658
51CSNK1A1L1.07901362
52SCYL21.03251835
53CSNK1G11.01894254
54MST1R0.99974176
55FER0.98450438
56MST40.97993231
57NEK10.95803114
58YES10.94398130
59NTRK20.93988393
60MET0.93442197
61BMPR1B0.91611942
62CSNK1G20.91320402
63RIPK10.90328962
64PAK20.90035783
65MAP2K40.88705694
66SGK30.87594455
67BRSK20.86267650
68MTOR0.84995072
69GRK10.84515745
70PRKAA10.82842630
71CDK90.82002201
72DYRK1B0.79911173
73NEK90.78869689
74SGK20.78734601
75OXSR10.77836698
76PRKCH0.76926068
77GSK3A0.73226421
78STK380.72667602
79MELK0.72419105
80TYRO30.72248831
81EEF2K0.71609341
82PRKCG0.71276690
83MKNK10.71134748
84BCR0.69617409
85BMX0.69183928
86HIPK20.67915353
87LMTK20.67612029
88ROCK10.67399698
89CAMK2A0.67112051
90MAPK130.66924862
91BMPR20.66918226
92FGFR40.66380752
93MUSK0.65288647
94DYRK30.65021563
95BRD40.64268011
96SIK30.64008743
97PNCK0.61785156
98CSNK1G30.61730241
99EIF2AK10.61535884
100CAMK2B0.61501397
101ERBB20.61109836
102MKNK20.61027171
103CDK50.58541070
104CAMK2D0.58412609
105NTRK30.57778373
106PIK3CA0.57173114
107NEK60.55954857
108PLK20.55898069
109PTK20.55563549
110PHKG10.55172173
111PHKG20.55172173
112KSR20.53500146
113MINK10.53335565
114SGK4940.52709112
115SGK2230.52709112
116CSNK1D0.52326308
117ADRBK20.50149940
118CASK0.49855744
119DYRK20.49188113
120ALK0.48483211
121RPS6KA40.47602497
122WNK10.47022007
123CDK120.46981441
124TTK0.46707955
125MAP3K90.45983261
126PRKAA20.45062682
127NTRK10.44286205
128UHMK10.42357039
129CHEK20.42107965
130PRKG10.42020481
131RPS6KA20.41657317
132DYRK1A0.41034600
133SRPK10.40754221
134OBSCN0.40669879
135PKN10.40148670
136SGK10.40132875
137DAPK20.39745263
138PLK30.39592355
139STK38L0.39198091
140RPS6KB10.38935644
141MAPK100.38770584
142PTK2B0.38450752
143ROCK20.37919207
144NLK0.36515184
145STK110.35756499
146TSSK60.34715694
147PRKACB0.33721930
148CSNK1E0.33014956

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.64340979
2Nicotine addiction_Homo sapiens_hsa050332.60481918
3Protein export_Homo sapiens_hsa030602.05537624
4Vitamin B6 metabolism_Homo sapiens_hsa007501.98066150
5GABAergic synapse_Homo sapiens_hsa047271.91148667
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85519161
7Amphetamine addiction_Homo sapiens_hsa050311.85172432
8Butanoate metabolism_Homo sapiens_hsa006501.81222044
9Lysine degradation_Homo sapiens_hsa003101.77183033
10Glutamatergic synapse_Homo sapiens_hsa047241.69248991
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65564348
12Sulfur metabolism_Homo sapiens_hsa009201.61040021
13Circadian entrainment_Homo sapiens_hsa047131.59303211
14Endometrial cancer_Homo sapiens_hsa052131.53229328
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50608688
16Adherens junction_Homo sapiens_hsa045201.49672798
17Focal adhesion_Homo sapiens_hsa045101.48839947
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48479210
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.43591720
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42339813
21Axon guidance_Homo sapiens_hsa043601.40262492
22MicroRNAs in cancer_Homo sapiens_hsa052061.38881345
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38427383
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38188226
25ECM-receptor interaction_Homo sapiens_hsa045121.38121382
26Taste transduction_Homo sapiens_hsa047421.36798303
27Colorectal cancer_Homo sapiens_hsa052101.36053299
28Synaptic vesicle cycle_Homo sapiens_hsa047211.35264373
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34994527
30Glioma_Homo sapiens_hsa052141.34963413
31mTOR signaling pathway_Homo sapiens_hsa041501.32767381
32Morphine addiction_Homo sapiens_hsa050321.32547308
33Type II diabetes mellitus_Homo sapiens_hsa049301.30650716
34Small cell lung cancer_Homo sapiens_hsa052221.29975527
35Chronic myeloid leukemia_Homo sapiens_hsa052201.29757053
36Proteoglycans in cancer_Homo sapiens_hsa052051.25919132
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25133406
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24300835
39Prostate cancer_Homo sapiens_hsa052151.23889149
40Insulin resistance_Homo sapiens_hsa049311.23671883
41Hippo signaling pathway_Homo sapiens_hsa043901.18695511
42Phototransduction_Homo sapiens_hsa047441.17180825
43Folate biosynthesis_Homo sapiens_hsa007901.14553401
44Pancreatic cancer_Homo sapiens_hsa052121.13875368
45Renal cell carcinoma_Homo sapiens_hsa052111.13184061
46Dorso-ventral axis formation_Homo sapiens_hsa043201.13051998
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12516428
48Fatty acid biosynthesis_Homo sapiens_hsa000611.12343951
49Serotonergic synapse_Homo sapiens_hsa047261.11086510
50Steroid biosynthesis_Homo sapiens_hsa001001.10098742
51Bladder cancer_Homo sapiens_hsa052191.09656149
52Fatty acid metabolism_Homo sapiens_hsa012121.09582875
53Arginine biosynthesis_Homo sapiens_hsa002201.09382507
54Circadian rhythm_Homo sapiens_hsa047101.09141482
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07476047
56Collecting duct acid secretion_Homo sapiens_hsa049661.07085162
57AMPK signaling pathway_Homo sapiens_hsa041521.06685541
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02807665
59Fatty acid degradation_Homo sapiens_hsa000711.01607552
60Long-term potentiation_Homo sapiens_hsa047201.01177151
61Long-term depression_Homo sapiens_hsa047301.00304565
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00211429
63Non-small cell lung cancer_Homo sapiens_hsa052231.00057529
64Dilated cardiomyopathy_Homo sapiens_hsa054140.99789889
65Propanoate metabolism_Homo sapiens_hsa006400.99757121
66Insulin signaling pathway_Homo sapiens_hsa049100.97584795
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94623388
68TGF-beta signaling pathway_Homo sapiens_hsa043500.94529721
69Vibrio cholerae infection_Homo sapiens_hsa051100.93972995
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93856170
71Estrogen signaling pathway_Homo sapiens_hsa049150.92748412
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92721172
73Ether lipid metabolism_Homo sapiens_hsa005650.92296489
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92029737
75Systemic lupus erythematosus_Homo sapiens_hsa053220.91684223
76Glucagon signaling pathway_Homo sapiens_hsa049220.91587620
77Tryptophan metabolism_Homo sapiens_hsa003800.91181547
78Melanoma_Homo sapiens_hsa052180.91110997
79Sphingolipid metabolism_Homo sapiens_hsa006000.90855154
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90610093
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90431895
82Basal cell carcinoma_Homo sapiens_hsa052170.89714915
83PPAR signaling pathway_Homo sapiens_hsa033200.89233984
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89130544
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88168914
86Oocyte meiosis_Homo sapiens_hsa041140.87070717
87ErbB signaling pathway_Homo sapiens_hsa040120.86860057
88Prolactin signaling pathway_Homo sapiens_hsa049170.85497422
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85323604
90Bile secretion_Homo sapiens_hsa049760.85278231
91FoxO signaling pathway_Homo sapiens_hsa040680.85041703
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84768321
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83398477
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83352940
95Insulin secretion_Homo sapiens_hsa049110.82540452
96Non-homologous end-joining_Homo sapiens_hsa034500.82273636
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.81987047
98Salivary secretion_Homo sapiens_hsa049700.81654075
99ABC transporters_Homo sapiens_hsa020100.81156179
100Thyroid hormone synthesis_Homo sapiens_hsa049180.79482870
101Alcoholism_Homo sapiens_hsa050340.79468242
102Protein digestion and absorption_Homo sapiens_hsa049740.79409216
103Basal transcription factors_Homo sapiens_hsa030220.79153171
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77980173
105Gap junction_Homo sapiens_hsa045400.77887375
106Tight junction_Homo sapiens_hsa045300.76707124
107Amoebiasis_Homo sapiens_hsa051460.76186216
108Wnt signaling pathway_Homo sapiens_hsa043100.75462680
109Selenocompound metabolism_Homo sapiens_hsa004500.74857955
110Melanogenesis_Homo sapiens_hsa049160.74813679
111Peroxisome_Homo sapiens_hsa041460.74327334
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73554379
113cAMP signaling pathway_Homo sapiens_hsa040240.73518457
114Inositol phosphate metabolism_Homo sapiens_hsa005620.73354871
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.72006460
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71665027
117Renin secretion_Homo sapiens_hsa049240.71620870
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.70899205
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69777511
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68032094
121GnRH signaling pathway_Homo sapiens_hsa049120.67273102
122Regulation of autophagy_Homo sapiens_hsa041400.66871505
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66653952
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66379594
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66128020
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65933015
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65467876
128Complement and coagulation cascades_Homo sapiens_hsa046100.64047584
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63181479
130Hedgehog signaling pathway_Homo sapiens_hsa043400.62282343
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.62139310
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62135774
133Pancreatic secretion_Homo sapiens_hsa049720.61823475
134Viral myocarditis_Homo sapiens_hsa054160.61782639
135Rap1 signaling pathway_Homo sapiens_hsa040150.61680112
136Dopaminergic synapse_Homo sapiens_hsa047280.61612801
137Cocaine addiction_Homo sapiens_hsa050300.61185568
138Cholinergic synapse_Homo sapiens_hsa047250.60039990
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59036631
140Ovarian steroidogenesis_Homo sapiens_hsa049130.58031025
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56705042
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56129143
143Pathways in cancer_Homo sapiens_hsa052000.56069916
144Calcium signaling pathway_Homo sapiens_hsa040200.55938117
145Oxytocin signaling pathway_Homo sapiens_hsa049210.51955179
146Gastric acid secretion_Homo sapiens_hsa049710.50948434
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.48536142
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47378752
149Olfactory transduction_Homo sapiens_hsa047400.42621303
150beta-Alanine metabolism_Homo sapiens_hsa004100.41943029
151N-Glycan biosynthesis_Homo sapiens_hsa005100.41560550

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