ZBTB43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.94549315
2L-phenylalanine catabolic process (GO:0006559)5.65815011
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65815011
4cell wall macromolecule catabolic process (GO:0016998)5.31877408
5somite development (GO:0061053)5.31683264
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.05355431
7L-phenylalanine metabolic process (GO:0006558)5.05355431
8aromatic amino acid family catabolic process (GO:0009074)5.04537191
9serine family amino acid catabolic process (GO:0009071)4.86541250
10kynurenine metabolic process (GO:0070189)4.85985111
11positive regulation of glomerulus development (GO:0090193)4.82295269
12cysteine metabolic process (GO:0006534)4.81782935
13bile acid biosynthetic process (GO:0006699)4.78645142
14cell wall macromolecule metabolic process (GO:0044036)4.62362436
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.57635739
16alpha-linolenic acid metabolic process (GO:0036109)4.52189751
17tryptophan catabolic process (GO:0006569)4.51982974
18indole-containing compound catabolic process (GO:0042436)4.51982974
19indolalkylamine catabolic process (GO:0046218)4.51982974
20protein K11-linked deubiquitination (GO:0035871)4.37080493
21negative regulation of astrocyte differentiation (GO:0048712)4.33097420
22glycine metabolic process (GO:0006544)4.32024182
23glyoxylate metabolic process (GO:0046487)4.30143219
24homocysteine metabolic process (GO:0050667)4.21478681
25tryptophan metabolic process (GO:0006568)4.10103815
26bile acid metabolic process (GO:0008206)4.07667645
27serine family amino acid metabolic process (GO:0009069)4.06236750
28negative regulation of heart growth (GO:0061117)4.01850174
29negative regulation of cardiac muscle tissue growth (GO:0055022)4.01850174
30dicarboxylic acid biosynthetic process (GO:0043650)3.90476210
31cellular ketone body metabolic process (GO:0046950)3.83932297
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.77735011
33regulation of bile acid biosynthetic process (GO:0070857)3.76199595
34adaptation of signaling pathway (GO:0023058)3.75548760
35negative regulation of cholesterol transport (GO:0032375)3.75331007
36negative regulation of sterol transport (GO:0032372)3.75331007
37urea cycle (GO:0000050)3.73206317
38urea metabolic process (GO:0019627)3.73206317
39negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.73137676
40peptidyl-glutamic acid carboxylation (GO:0017187)3.69508256
41protein carboxylation (GO:0018214)3.69508256
42serine family amino acid biosynthetic process (GO:0009070)3.69095422
43high-density lipoprotein particle remodeling (GO:0034375)3.64181408
44acylglycerol homeostasis (GO:0055090)3.62362247
45triglyceride homeostasis (GO:0070328)3.62362247
46sulfur amino acid catabolic process (GO:0000098)3.62092429
47lung morphogenesis (GO:0060425)3.57817500
48negative regulation of fibrinolysis (GO:0051918)3.57083829
49alpha-amino acid catabolic process (GO:1901606)3.56338995
50regulation of fibrinolysis (GO:0051917)3.55564044
51amino-acid betaine metabolic process (GO:0006577)3.55402441
52lysine metabolic process (GO:0006553)3.54544492
53lysine catabolic process (GO:0006554)3.54544492
54snRNA transcription (GO:0009301)3.53208959
55S-adenosylmethionine metabolic process (GO:0046500)3.49998735
56complement activation, alternative pathway (GO:0006957)3.48448448
57regulation of protein activation cascade (GO:2000257)3.47346711
58aromatic amino acid family metabolic process (GO:0009072)3.43540345
59pyridine nucleotide biosynthetic process (GO:0019363)3.37896077
60nicotinamide nucleotide biosynthetic process (GO:0019359)3.37896077
61regulation of cholesterol homeostasis (GO:2000188)3.36657246
62regulation of receptor binding (GO:1900120)3.36037302
63acetyl-CoA metabolic process (GO:0006084)3.35972559
64neural tube formation (GO:0001841)3.34979713
65glutamate metabolic process (GO:0006536)3.34104751
66ketone body metabolic process (GO:1902224)3.34069292
67reverse cholesterol transport (GO:0043691)3.30639426
68L-serine metabolic process (GO:0006563)3.29967080
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.28262258
70negative regulation of systemic arterial blood pressure (GO:0003085)3.25358816
71plasma lipoprotein particle clearance (GO:0034381)3.24416821
72cellular amino acid catabolic process (GO:0009063)3.23150205
73negative regulation of cardiac muscle tissue development (GO:0055026)3.18851096
74pyridine-containing compound biosynthetic process (GO:0072525)3.18752543
75regulation of glomerulus development (GO:0090192)3.18652836
76cellular modified amino acid catabolic process (GO:0042219)3.18457227
77DNA methylation involved in gamete generation (GO:0043046)3.17834390
78regulation of complement activation (GO:0030449)3.14960737
79fatty acid homeostasis (GO:0055089)3.14332153
80response to pheromone (GO:0019236)3.14262190
81platelet dense granule organization (GO:0060155)3.13384217
82cholesterol efflux (GO:0033344)3.11882073
83establishment of protein localization to Golgi (GO:0072600)3.11865727
84positive regulation of neurological system process (GO:0031646)3.09019952
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.08747395
86nitrogen cycle metabolic process (GO:0071941)3.08486757
87bile acid and bile salt transport (GO:0015721)3.07484474
88negative regulation of interleukin-1 beta production (GO:0032691)3.04927771
89prenylation (GO:0097354)3.04900088
90protein prenylation (GO:0018342)3.04900088
91indolalkylamine metabolic process (GO:0006586)3.04624886
92plasma lipoprotein particle remodeling (GO:0034369)3.02892219
93protein-lipid complex remodeling (GO:0034368)3.02892219
94macromolecular complex remodeling (GO:0034367)3.02892219
95behavioral response to nicotine (GO:0035095)3.01911866
96protein polyglutamylation (GO:0018095)2.98627791
97monoubiquitinated protein deubiquitination (GO:0035520)2.98470030
98regulation of glucokinase activity (GO:0033131)2.97765140
99regulation of hexokinase activity (GO:1903299)2.97765140
100cholesterol homeostasis (GO:0042632)2.97428594
101cellular response to ethanol (GO:0071361)2.96394593
102regulation of triglyceride catabolic process (GO:0010896)2.95250752
103regulation of heat generation (GO:0031650)2.94768470
104regulation of alkaline phosphatase activity (GO:0010692)2.93894756
105regulation of energy homeostasis (GO:2000505)2.92937125
106response to inactivity (GO:0014854)2.92454329
107positive regulation of lipid catabolic process (GO:0050996)2.92282170
108detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92100538
109sterol homeostasis (GO:0055092)2.91817041
110phospholipid efflux (GO:0033700)2.90073434
1112-oxoglutarate metabolic process (GO:0006103)2.87447408
112protein K63-linked deubiquitination (GO:0070536)2.86866179
113regulation of cholesterol esterification (GO:0010872)2.86308454
114tyrosine metabolic process (GO:0006570)2.85209977
115interferon-gamma production (GO:0032609)2.84326264
116L-fucose metabolic process (GO:0042354)2.81961005
117L-fucose catabolic process (GO:0042355)2.81961005
118fucose catabolic process (GO:0019317)2.81961005
119amine catabolic process (GO:0009310)2.81105844
120cellular biogenic amine catabolic process (GO:0042402)2.81105844
121drug catabolic process (GO:0042737)2.80484346
122piRNA metabolic process (GO:0034587)2.80151994
123protein targeting to Golgi (GO:0000042)2.79902257
124replication fork processing (GO:0031297)2.77856874
125detection of light stimulus involved in sensory perception (GO:0050962)2.77748051
126detection of light stimulus involved in visual perception (GO:0050908)2.77748051
127negative regulation of mast cell activation (GO:0033004)2.77398141
128very long-chain fatty acid metabolic process (GO:0000038)2.76105042
129aspartate family amino acid catabolic process (GO:0009068)2.74622120
130lipoprotein metabolic process (GO:0042157)2.71400658
131plasma lipoprotein particle assembly (GO:0034377)2.69501189
132retinal cone cell development (GO:0046549)2.69461647
133pyrimidine nucleobase catabolic process (GO:0006208)2.69080047
134morphogenesis of an epithelial fold (GO:0060571)2.68081642
135regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66421000
136keratinocyte development (GO:0003334)2.64314280
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64228739
138pyrimidine dimer repair (GO:0006290)2.64115715
139regulation of translation, ncRNA-mediated (GO:0045974)2.63951895
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63951895
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.63951895
142gamma-aminobutyric acid transport (GO:0015812)2.60930409
143retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60377019
144histone mRNA catabolic process (GO:0071044)2.59953262
145cilium morphogenesis (GO:0060271)2.59889737
146positive regulation of mRNA catabolic process (GO:0061014)2.59483913
147anterograde synaptic vesicle transport (GO:0048490)2.59325702
148RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58896321
149rRNA catabolic process (GO:0016075)2.58665302
150preassembly of GPI anchor in ER membrane (GO:0016254)2.56677376
151DNA demethylation (GO:0080111)2.55111887
152DNA double-strand break processing (GO:0000729)2.52499150
153positive regulation of T-helper 1 type immune response (GO:0002827)2.52155425
154regulation of meiosis I (GO:0060631)2.51258339
155histone H2A ubiquitination (GO:0033522)2.48313447
156negative regulation of DNA-dependent DNA replication (GO:2000104)2.47928272
157axoneme assembly (GO:0035082)2.47600246
158negative regulation of interleukin-1 production (GO:0032692)2.44857739
159regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43631995
160photoreceptor cell maintenance (GO:0045494)2.43212131
161indole-containing compound metabolic process (GO:0042430)2.43206613
162signal peptide processing (GO:0006465)2.43106289
163positive regulation of heat generation (GO:0031652)2.43081675
164positive regulation of defense response to virus by host (GO:0002230)2.42684031
165regulation of relaxation of muscle (GO:1901077)2.42441184
166polyol catabolic process (GO:0046174)2.40088225
167DNA deamination (GO:0045006)2.37692049
168inositol phosphate catabolic process (GO:0071545)2.37314820
169regulation of germinal center formation (GO:0002634)2.37076171
170positive regulation of meiotic cell cycle (GO:0051446)2.36342305
171histone H3-K4 trimethylation (GO:0080182)2.35466529
172male meiosis (GO:0007140)2.34597834
173recombinational repair (GO:0000725)2.34308494
174negative regulation of neurological system process (GO:0031645)2.33520989
175exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33439808
176double-strand break repair via homologous recombination (GO:0000724)2.33130682
177nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28207504
178positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.27130556
179regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.27130556
180regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.26191471
181regulation of mitotic spindle checkpoint (GO:1903504)2.26191471
182negative regulation of JUN kinase activity (GO:0043508)2.25999577
183RNA destabilization (GO:0050779)2.25236733
184regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.23802384
185positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.23802384
186regulation of sarcomere organization (GO:0060297)2.23557931
187cornea development in camera-type eye (GO:0061303)2.23429933
188positive regulation of meiosis (GO:0045836)2.23375715
189protein localization to Golgi apparatus (GO:0034067)2.22642539
190multicellular organism reproduction (GO:0032504)2.21611808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.88910091
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.21627035
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.71525375
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.52793611
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.14012653
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.77891478
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45555875
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33686980
9VDR_22108803_ChIP-Seq_LS180_Human3.02985374
10ZNF263_19887448_ChIP-Seq_K562_Human2.98430051
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.98227808
12ZNF274_21170338_ChIP-Seq_K562_Hela2.97719432
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91446071
14IGF1R_20145208_ChIP-Seq_DFB_Human2.85384822
15GBX2_23144817_ChIP-Seq_PC3_Human2.84080618
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84028779
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77131141
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62424792
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.49334072
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39211442
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36493600
22E2F7_22180533_ChIP-Seq_HELA_Human2.32132201
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28867577
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28448952
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28448952
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28448952
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.21106677
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13724163
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11205012
30P300_19829295_ChIP-Seq_ESCs_Human2.08906191
31TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01275725
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97345282
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96580371
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.91633329
35CLOCK_20551151_ChIP-Seq_293T_Human1.88491959
36* ER_23166858_ChIP-Seq_MCF-7_Human1.84556435
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83200699
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82712817
39EZH2_22144423_ChIP-Seq_EOC_Human1.80797642
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80792527
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80377237
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79363980
43CBP_20019798_ChIP-Seq_JUKART_Human1.75699873
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75699873
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.75421762
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74553725
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.71567047
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71326520
49SMAD4_21799915_ChIP-Seq_A2780_Human1.70545300
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68942812
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.67719019
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.67271348
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.66162972
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64899389
55STAT3_23295773_ChIP-Seq_U87_Human1.62575633
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60728346
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60583888
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59986294
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.56380690
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.56098823
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52756187
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51610343
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51305044
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49658572
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49104598
66ELK1_19687146_ChIP-ChIP_HELA_Human1.47706373
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47444436
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44879028
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.44837011
70* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41163656
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40205671
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39879648
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39300516
74* TCF4_23295773_ChIP-Seq_U87_Human1.39131057
75AR_21909140_ChIP-Seq_LNCAP_Human1.38473493
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.37877470
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37603403
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.37353414
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37305332
80TP53_16413492_ChIP-PET_HCT116_Human1.35520912
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.35232208
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35054564
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35048310
84AR_25329375_ChIP-Seq_VCAP_Human1.34416113
85SOX2_19829295_ChIP-Seq_ESCs_Human1.34107350
86NANOG_19829295_ChIP-Seq_ESCs_Human1.34107350
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.34044439
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.33149615
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31615705
90TCF4_22108803_ChIP-Seq_LS180_Human1.30969297
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.30733003
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.30489648
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30415130
94CDX2_22108803_ChIP-Seq_LS180_Human1.29358678
95TAF15_26573619_Chip-Seq_HEK293_Human1.28447760
96GATA1_22025678_ChIP-Seq_K562_Human1.27578351
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25057796
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24371549
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24299689
100HNF4A_19822575_ChIP-Seq_HepG2_Human1.23194443
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23062239
102* P53_22387025_ChIP-Seq_ESCs_Mouse1.22314501
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21251477
104RUNX2_22187159_ChIP-Seq_PCA_Human1.21086562
105NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20381840
106* E2F1_18555785_Chip-Seq_ESCs_Mouse1.19828014
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19141707
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19008537
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.18881096
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.18631851
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18075811
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.15400715
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14977717
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14465538
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14329468
116* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14193741
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14084207
118TP53_22573176_ChIP-Seq_HFKS_Human1.13428721
119NANOG_16518401_ChIP-PET_MESCs_Mouse1.12756888
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12259858
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.12202384
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11418472
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10677333
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.10665888
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10448511
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10032054
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09478227
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09137027
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07757031
130RXR_22108803_ChIP-Seq_LS180_Human1.07569468
131SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07302220
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07035886
133VDR_23849224_ChIP-Seq_CD4+_Human1.06737094
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06297275
135* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05924734
136* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05783074
137* P300_18555785_Chip-Seq_ESCs_Mouse1.04609354
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03584919
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.02480233
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02118040
141* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02089539
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.01949326
143PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01245877
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00727291
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00653457
146AR_21572438_ChIP-Seq_LNCaP_Human0.99754893
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98650370
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97564795
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96695523
150RARB_27405468_Chip-Seq_BRAIN_Mouse0.95662599
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95474753
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94409288
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94409288
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94177764
155BCAT_22108803_ChIP-Seq_LS180_Human0.93932386
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.92784060
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92503316
158POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91445156
159NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90743565
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88899646
161HTT_18923047_ChIP-ChIP_STHdh_Human0.88880038
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.88180783
163TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88043665
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86435306
165ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86181764
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85609057
167VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85092244
168ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84747010
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.84525149
170* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83649449
171TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83095884
172EWS_26573619_Chip-Seq_HEK293_Human0.83036447
173FUS_26573619_Chip-Seq_HEK293_Human0.82962839
174AHR_22903824_ChIP-Seq_MCF-7_Human0.82334128
175TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82288155
176SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81778549
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81724607
178NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80788042
179NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79116502
180NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79116502
181GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.79060049
182AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75582650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.36117467
2MP0005360_urolithiasis5.76545483
3MP0005365_abnormal_bile_salt4.84542952
4MP0005085_abnormal_gallbladder_physiolo4.71056604
5MP0000569_abnormal_digit_pigmentation4.66978962
6MP0003646_muscle_fatigue4.11014502
7MP0003806_abnormal_nucleotide_metabolis3.67924956
8MP0000537_abnormal_urethra_morphology3.51269386
9MP0008875_abnormal_xenobiotic_pharmacok3.46696061
10MP0009053_abnormal_anal_canal3.45160476
11MP0010329_abnormal_lipoprotein_level2.86377801
12MP0003252_abnormal_bile_duct2.67130957
13MP0000372_irregular_coat_pigmentation2.62360680
14MP0005646_abnormal_pituitary_gland2.57102616
15MP0003690_abnormal_glial_cell2.45324979
16MP0009697_abnormal_copulation2.21551312
17MP0009384_cardiac_valve_regurgitation2.19238423
18MP0001661_extended_life_span2.02322339
19MP0004510_myositis2.01909623
20MP0002102_abnormal_ear_morphology1.99276429
21MP0004142_abnormal_muscle_tone1.99104659
22MP0000427_abnormal_hair_cycle1.94290694
23MP0003787_abnormal_imprinting1.94240765
24MP0000609_abnormal_liver_physiology1.91803821
25MP0008877_abnormal_DNA_methylation1.89128278
26MP0001984_abnormal_olfaction1.88588274
27MP0010234_abnormal_vibrissa_follicle1.84528798
28MP0002332_abnormal_exercise_endurance1.83205795
29MP0005332_abnormal_amino_acid1.76955362
30MP0001666_abnormal_nutrient_absorption1.75155924
31MP0001501_abnormal_sleep_pattern1.75009504
32MP0008058_abnormal_DNA_repair1.73465246
33MP0005174_abnormal_tail_pigmentation1.68034894
34MP0004215_abnormal_myocardial_fiber1.67503912
35MP0009840_abnormal_foam_cell1.65646458
36MP0005253_abnormal_eye_physiology1.64649116
37MP0004484_altered_response_of1.58819450
38MP0003938_abnormal_ear_development1.58810297
39MP0005075_abnormal_melanosome_morpholog1.58008212
40MP0002095_abnormal_skin_pigmentation1.57083325
41MP0003656_abnormal_erythrocyte_physiolo1.55267455
42MP0002118_abnormal_lipid_homeostasis1.53735874
43MP0002876_abnormal_thyroid_physiology1.49297405
44MP0003011_delayed_dark_adaptation1.48216846
45MP0000467_abnormal_esophagus_morphology1.47643033
46MP0004885_abnormal_endolymph1.47055933
47MP0004145_abnormal_muscle_electrophysio1.46846380
48MP0005645_abnormal_hypothalamus_physiol1.46722518
49MP0005319_abnormal_enzyme/_coenzyme1.45073981
50MP0000015_abnormal_ear_pigmentation1.42454407
51MP0009046_muscle_twitch1.40630107
52MP0002282_abnormal_trachea_morphology1.35202654
53MP0003880_abnormal_central_pattern1.33887779
54MP0003119_abnormal_digestive_system1.30213348
55MP0002638_abnormal_pupillary_reflex1.29296211
56MP0006072_abnormal_retinal_apoptosis1.23901476
57MP0001986_abnormal_taste_sensitivity1.22701261
58MP0003195_calcinosis1.22267803
59MP0005386_behavior/neurological_phenoty1.22167428
60MP0004924_abnormal_behavior1.22167428
61MP0009764_decreased_sensitivity_to1.20930556
62MP0008057_abnormal_DNA_replication1.19753801
63MP0003786_premature_aging1.19348337
64MP0003868_abnormal_feces_composition1.18595744
65MP0003705_abnormal_hypodermis_morpholog1.16595292
66MP0000371_diluted_coat_color1.15268480
67MP0001853_heart_inflammation1.14574186
68MP0000749_muscle_degeneration1.13806805
69MP0004084_abnormal_cardiac_muscle1.12878969
70MP0010307_abnormal_tumor_latency1.12779198
71MP0005084_abnormal_gallbladder_morpholo1.12718583
72MP0004130_abnormal_muscle_cell1.12051929
73MP0002234_abnormal_pharynx_morphology1.10793613
74MP0010678_abnormal_skin_adnexa1.10673693
75MP0002148_abnormal_hypersensitivity_rea1.07948771
76MP0004185_abnormal_adipocyte_glucose1.07864999
77MP0005310_abnormal_salivary_gland1.02389850
78MP0009745_abnormal_behavioral_response1.02278590
79MP0004197_abnormal_fetal_growth/weight/1.01545693
80MP0002735_abnormal_chemical_nociception1.00864054
81MP0009785_altered_susceptibility_to0.99792098
82MP0001764_abnormal_homeostasis0.99291708
83MP0000604_amyloidosis0.99134867
84MP0001730_embryonic_growth_arrest0.97533429
85MP0001727_abnormal_embryo_implantation0.96866412
86MP0001324_abnormal_eye_pigmentation0.96760693
87MP0002277_abnormal_respiratory_mucosa0.95549163
88MP0009672_abnormal_birth_weight0.95502907
89MP0005647_abnormal_sex_gland0.95383895
90MP0003121_genomic_imprinting0.93396039
91MP0004264_abnormal_extraembryonic_tissu0.93395974
92MP0003045_fibrosis0.92905062
93MP0003890_abnormal_embryonic-extraembry0.92469081
94MP0000647_abnormal_sebaceous_gland0.91269335
95MP0006054_spinal_hemorrhage0.89498021
96MP0002138_abnormal_hepatobiliary_system0.89274140
97MP0003221_abnormal_cardiomyocyte_apopto0.89134414
98MP0006292_abnormal_olfactory_placode0.88287269
99MP0003937_abnormal_limbs/digits/tail_de0.87735940
100MP0005666_abnormal_adipose_tissue0.87567296
101MP0004147_increased_porphyrin_level0.86503468
102MP0008995_early_reproductive_senescence0.86332113
103MP0005671_abnormal_response_to0.85591904
104MP0002108_abnormal_muscle_morphology0.85142188
105MP0002736_abnormal_nociception_after0.83350956
106MP0008872_abnormal_physiological_respon0.82842706
107MP0000778_abnormal_nervous_system0.81131290
108MP0002971_abnormal_brown_adipose0.80924766
109MP0002272_abnormal_nervous_system0.80763710
110MP0000598_abnormal_liver_morphology0.80208625
111MP0003950_abnormal_plasma_membrane0.80128993
112MP0002106_abnormal_muscle_physiology0.79534692
113MP0001915_intracranial_hemorrhage0.78860177
114MP0002837_dystrophic_cardiac_calcinosis0.78628639
115MP0005620_abnormal_muscle_contractility0.78625835
116MP0003567_abnormal_fetal_cardiomyocyte0.78281506
117MP0004043_abnormal_pH_regulation0.77666059
118MP0000428_abnormal_craniofacial_morphol0.77414596
119MP0002938_white_spotting0.77281675
120MP0003136_yellow_coat_color0.77260714
121MP0002972_abnormal_cardiac_muscle0.76517110
122MP0001929_abnormal_gametogenesis0.76341463
123MP0002086_abnormal_extraembryonic_tissu0.76205717
124MP0005266_abnormal_metabolism0.75676621
125MP0000462_abnormal_digestive_system0.74378907
126MP0002127_abnormal_cardiovascular_syste0.74252921
127MP0002090_abnormal_vision0.74028237
128MP0001440_abnormal_grooming_behavior0.73489735
129MP0001968_abnormal_touch/_nociception0.73456472
130MP0008961_abnormal_basal_metabolism0.73179938
131MP0004381_abnormal_hair_follicle0.73137686
132MP0001485_abnormal_pinna_reflex0.72700097
133MP0004019_abnormal_vitamin_homeostasis0.72224113
134MP0004036_abnormal_muscle_relaxation0.71876883
135MP0005408_hypopigmentation0.71708731
136MP0002693_abnormal_pancreas_physiology0.71528592
137MP0002653_abnormal_ependyma_morphology0.71208744
138MP0002254_reproductive_system_inflammat0.71179806
139MP0005167_abnormal_blood-brain_barrier0.70931585
140MP0005551_abnormal_eye_electrophysiolog0.70710517
141MP0003984_embryonic_growth_retardation0.68595662
142MP0009703_decreased_birth_body0.68261704
143MP0002088_abnormal_embryonic_growth/wei0.68029041
144MP0001919_abnormal_reproductive_system0.67908738
145MP0002928_abnormal_bile_duct0.67609993
146MP0001486_abnormal_startle_reflex0.67278201
147MP0002796_impaired_skin_barrier0.65831734
148MP0000383_abnormal_hair_follicle0.65342257
149MP0008775_abnormal_heart_ventricle0.64160906
150MP0005389_reproductive_system_phenotype0.64072206
151MP0001800_abnormal_humoral_immune0.64010975
152MP0005187_abnormal_penis_morphology0.63979286
153MP0000003_abnormal_adipose_tissue0.63618300
154MP0005376_homeostasis/metabolism_phenot0.63238277
155MP0002084_abnormal_developmental_patter0.62345588
156MP0001672_abnormal_embryogenesis/_devel0.61644988
157MP0005380_embryogenesis_phenotype0.61644988
158MP0005375_adipose_tissue_phenotype0.61563062
159MP0000653_abnormal_sex_gland0.61493898
160MP0005535_abnormal_body_temperature0.61478121
161MP0003123_paternal_imprinting0.58916906
162MP0003632_abnormal_nervous_system0.58726698
163MP0002009_preneoplasia0.57688187
164MP0001697_abnormal_embryo_size0.57656119
165MP0005248_abnormal_Harderian_gland0.57473641
166MP0003718_maternal_effect0.57336272
167MP0002111_abnormal_tail_morphology0.57183095
168MP0004957_abnormal_blastocyst_morpholog0.55995034
169MP0005451_abnormal_body_composition0.55953676
170MP0002932_abnormal_joint_morphology0.55355552
171MP0001145_abnormal_male_reproductive0.55121562
172MP0000631_abnormal_neuroendocrine_gland0.54905535

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the proximal phalanges of the hand (HP:0009834)6.76348252
2Abnormality of the nasal septum (HP:0000419)5.55045477
3Intrahepatic cholestasis (HP:0001406)4.81853962
4Short 1st metacarpal (HP:0010034)4.79867860
5Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.79867860
6Abnormality of the middle phalanges of the toes (HP:0010183)4.58987101
7Abnormality of the 1st metacarpal (HP:0010009)4.27277121
8Hypobetalipoproteinemia (HP:0003563)4.23502229
9Abnormality of the columella (HP:0009929)4.19378740
10Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.01518402
11Deep venous thrombosis (HP:0002625)3.93491758
12Short hallux (HP:0010109)3.91824159
13Pancreatic cysts (HP:0001737)3.90587525
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.83989884
15Xanthomatosis (HP:0000991)3.71927237
16Short phalanx of the thumb (HP:0009660)3.70083486
17Aplasia/Hypoplasia of the hallux (HP:0008362)3.66545461
18Prolonged partial thromboplastin time (HP:0003645)3.61873238
19Fused cervical vertebrae (HP:0002949)3.55560592
20Synostosis involving the elbow (HP:0003938)3.52356752
21Humeroradial synostosis (HP:0003041)3.52356752
22Hyperlipoproteinemia (HP:0010980)3.49161250
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47290605
24Pancreatic fibrosis (HP:0100732)3.43569700
25Aplasia/Hypoplasia of the sternum (HP:0006714)3.41167229
26Short humerus (HP:0005792)3.28847512
27Renal cortical cysts (HP:0000803)3.23041029
28Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.21638477
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.20158880
30Abnormality of serine family amino acid metabolism (HP:0010894)3.19166353
31Abnormality of glycine metabolism (HP:0010895)3.19166353
32Epidermoid cyst (HP:0200040)3.17511468
33Molar tooth sign on MRI (HP:0002419)3.15920600
34Abnormality of midbrain morphology (HP:0002418)3.15920600
35Hyperglycinemia (HP:0002154)3.15650742
36Hyperglycinuria (HP:0003108)3.14938291
37Abnormality of the renal cortex (HP:0011035)3.12967983
38True hermaphroditism (HP:0010459)3.07681143
39Broad hallux (HP:0010055)3.06035521
40Hypolipoproteinemia (HP:0010981)3.03480479
41Medial flaring of the eyebrow (HP:0010747)3.02509270
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.94089582
43Congenital stationary night blindness (HP:0007642)2.94047309
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92510079
45Aplasia/hypoplasia of the humerus (HP:0006507)2.87289505
46Gaze-evoked nystagmus (HP:0000640)2.85235621
47Proximal placement of thumb (HP:0009623)2.79826708
48Aplasia involving bones of the extremities (HP:0009825)2.77506473
49Aplasia involving bones of the upper limbs (HP:0009823)2.77506473
50Aplasia of the phalanges of the hand (HP:0009802)2.77506473
51Hypochromic microcytic anemia (HP:0004840)2.76579342
522-3 toe syndactyly (HP:0004691)2.75693376
53Fat malabsorption (HP:0002630)2.75456147
54Abnormality of the labia minora (HP:0012880)2.72176807
55Symphalangism affecting the phalanges of the hand (HP:0009773)2.71466559
56Nephronophthisis (HP:0000090)2.71452315
57Hypothermia (HP:0002045)2.71419202
58Long nose (HP:0003189)2.70947404
59Broad-based gait (HP:0002136)2.69723856
60Attenuation of retinal blood vessels (HP:0007843)2.67389721
61Hepatoblastoma (HP:0002884)2.65541039
62Stomatitis (HP:0010280)2.63621736
63Complement deficiency (HP:0004431)2.63067053
64Methylmalonic acidemia (HP:0002912)2.62032768
65Progressive inability to walk (HP:0002505)2.60550817
66Depressed nasal tip (HP:0000437)2.60295919
67Abnormality of the distal phalanges of the toes (HP:0010182)2.59519414
68Stomach cancer (HP:0012126)2.58972537
69Abnormality of the renal medulla (HP:0100957)2.55483735
70Hyperammonemia (HP:0001987)2.54246653
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.54187166
72Febrile seizures (HP:0002373)2.52688555
73Dislocated radial head (HP:0003083)2.48146415
74Deviation of the thumb (HP:0009603)2.47167099
75Hypoalphalipoproteinemia (HP:0003233)2.46225208
76Abnormality of the costochondral junction (HP:0000919)2.46122848
77Chronic hepatic failure (HP:0100626)2.45252270
78Widely spaced teeth (HP:0000687)2.41568199
79Broad toe (HP:0001837)2.41293894
80Ketosis (HP:0001946)2.40990189
81Morphological abnormality of the middle ear (HP:0008609)2.39874483
82Gout (HP:0001997)2.38898354
83Absent phalangeal crease (HP:0006109)2.37854696
84Abnormality of the radial head (HP:0003995)2.36996976
85Hemorrhage of the eye (HP:0011885)2.35259552
86Facial hemangioma (HP:0000329)2.34156081
87Neonatal hypoglycemia (HP:0001998)2.33538457
88Parakeratosis (HP:0001036)2.26674479
89Synostosis of carpal bones (HP:0005048)2.26058311
90Albinism (HP:0001022)2.25728109
91Generalized hypopigmentation of hair (HP:0011358)2.25639608
92Large for gestational age (HP:0001520)2.25135492
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.24409877
94Gait imbalance (HP:0002141)2.24307292
95Congenital primary aphakia (HP:0007707)2.21905607
96Spontaneous abortion (HP:0005268)2.17624151
97Hyperventilation (HP:0002883)2.17598622
98Erythroderma (HP:0001019)2.17436116
99Adactyly (HP:0009776)2.17305072
100Pseudobulbar signs (HP:0002200)2.14446812
101Abnormality of the renal collecting system (HP:0004742)2.13757224
102Duplicated collecting system (HP:0000081)2.11431600
103Inability to walk (HP:0002540)2.10660520
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10264439
105Nephrogenic diabetes insipidus (HP:0009806)2.10079305
106Spastic diplegia (HP:0001264)2.09745494
107Protruding tongue (HP:0010808)2.09591271
108Abolished electroretinogram (ERG) (HP:0000550)2.07288422
109Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06134269
110Absent speech (HP:0001344)2.05739686
111Abnormality of the common coagulation pathway (HP:0010990)2.05197357
112Furrowed tongue (HP:0000221)2.05161795
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04469343
114Steatorrhea (HP:0002570)2.04244917
115Calf muscle hypertrophy (HP:0008981)2.04039759
116Ketoacidosis (HP:0001993)2.03890708
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.03707427
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03650310
119Abnormality of methionine metabolism (HP:0010901)2.03401718
120Cubitus valgus (HP:0002967)2.03273405
121Abnormal finger flexion creases (HP:0006143)2.01905834
122Absent toe (HP:0010760)2.01110487
123Congenital hepatic fibrosis (HP:0002612)2.00543900
124Alveolar cell carcinoma (HP:0006519)1.99947448
125Neoplasm of the tracheobronchial system (HP:0100552)1.98170240
126Hypercholesterolemia (HP:0003124)1.96398168
127Progressive cerebellar ataxia (HP:0002073)1.95939524
128Type II lissencephaly (HP:0007260)1.95562963
129Volvulus (HP:0002580)1.95208432
130Sparse lateral eyebrow (HP:0005338)1.94735942
131Abnormality of pyrimidine metabolism (HP:0004353)1.94446711
132Thyroiditis (HP:0100646)1.92937556
133Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92764626
134Anencephaly (HP:0002323)1.91663192
135Muscle hypertrophy of the lower extremities (HP:0008968)1.91406928
136Abnormal rod and cone electroretinograms (HP:0008323)1.90817273
137Short tibia (HP:0005736)1.90120950
138Abnormality of the diencephalon (HP:0010662)1.89964715
139Abnormality of alanine metabolism (HP:0010916)1.88741759
140Hyperalaninemia (HP:0003348)1.88741759
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88741759
142Confusion (HP:0001289)1.86437832
143Genital tract atresia (HP:0001827)1.86212906
144Cystic liver disease (HP:0006706)1.85926896
145Fair hair (HP:0002286)1.85840852
146Upper motor neuron abnormality (HP:0002127)1.85655194
147Vertebral fusion (HP:0002948)1.85304881
148Methylmalonic aciduria (HP:0012120)1.84767263
149Abnormality of fatty-acid metabolism (HP:0004359)1.83765827
150Concave nail (HP:0001598)1.82162785
151Sensorimotor neuropathy (HP:0007141)1.80927225
152Sclerocornea (HP:0000647)1.80748968
153Dialeptic seizures (HP:0011146)1.80229635
154Median cleft lip (HP:0000161)1.79793044
155Abnormality of macular pigmentation (HP:0008002)1.79758756
156Spastic paraparesis (HP:0002313)1.78794198
157Myocardial infarction (HP:0001658)1.78667540
158Genetic anticipation (HP:0003743)1.74669699
159Pendular nystagmus (HP:0012043)1.74512201
160Hypoplastic iliac wings (HP:0002866)1.73718739
161Abnormality of the fingertips (HP:0001211)1.73631071
162Lissencephaly (HP:0001339)1.73448640
163Skin nodule (HP:0200036)1.73443300
164Frequent falls (HP:0002359)1.73300251
165Abnormality of the pons (HP:0007361)1.73200262
166Mitral stenosis (HP:0001718)1.73109450
167Increased corneal curvature (HP:0100692)1.73047666
168Keratoconus (HP:0000563)1.73047666
169Rimmed vacuoles (HP:0003805)1.72371046
170Tubular atrophy (HP:0000092)1.72228079
171Vaginal atresia (HP:0000148)1.71759815
172Abnormality of serum amino acid levels (HP:0003112)1.70401010
173Ependymoma (HP:0002888)1.70028071
174Abnormality of the axillary hair (HP:0100134)1.69696748
175Abnormality of secondary sexual hair (HP:0009888)1.69696748
176Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69056929
177Hip dysplasia (HP:0001385)1.67827618
178Atonic seizures (HP:0010819)1.67106799
179Clubbing of toes (HP:0100760)1.66209439
180Male pseudohermaphroditism (HP:0000037)1.65395645
181Intestinal atresia (HP:0011100)1.65117595
182Muscle fiber inclusion bodies (HP:0100299)1.65002816
183Congenital sensorineural hearing impairment (HP:0008527)1.64656596
184Ectropion (HP:0000656)1.64611896
185Hemiparesis (HP:0001269)1.64281516
186Congenital, generalized hypertrichosis (HP:0004540)1.64174966
187Cerebellar dysplasia (HP:0007033)1.62515754
188Drooling (HP:0002307)1.61710961
189Aplasia/Hypoplasia of the uvula (HP:0010293)1.61675260
190Progressive macrocephaly (HP:0004481)1.61567926
191Decreased central vision (HP:0007663)1.61026543
192Abnormality of vitamin B metabolism (HP:0004340)1.60813807
193Small hand (HP:0200055)1.59812491
194Abnormal drinking behavior (HP:0030082)1.59640838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.55522092
2ACVR1B3.27602874
3CDK123.27288077
4PASK3.15376472
5EPHA43.01155827
6INSRR2.98409706
7TXK2.95899397
8BMPR1B2.76729672
9TAOK32.62792794
10MAP3K92.51122906
11EIF2AK32.46233147
12MAP4K22.41319347
13OBSCN2.31263561
14FGFR22.21240432
15FRK2.20144454
16TYRO32.17855014
17MKNK22.07608062
18PKN22.05060035
19CASK2.01935978
20GRK72.01456861
21TRIM281.95535647
22NUAK11.94359938
23EPHA21.85197165
24ERBB41.81825475
25ADRBK21.73959587
26STK38L1.73071886
27MAPK111.70106479
28BCKDK1.66100875
29WNK31.65621566
30ERBB31.65296311
31DAPK21.60295364
32STK241.58003869
33SIK11.57288230
34BCR1.49151002
35RIPK11.44431288
36STK31.40857925
37MST41.40488491
38GRK11.36182650
39PINK11.35071827
40CAMKK11.34606326
41WEE11.33745908
42MAPK71.32980266
43FGR1.24538614
44PKN11.22045434
45ICK1.20155858
46PRPF4B1.20123471
47BRSK21.19938494
48IKBKB1.13369140
49OXSR11.12666904
50SIK21.11036129
51CSNK1D1.07477723
52STK391.07201548
53MAP3K71.06673266
54LATS11.05726258
55SGK21.03807190
56IRAK11.03009150
57TGFBR21.01155465
58TSSK61.00763049
59TGFBR11.00084801
60ZAK0.99565400
61KSR10.99059796
62PDGFRA0.99016300
63PDGFRB0.98706874
64TRPM70.98322747
65MKNK10.97833128
66FGFR40.97474616
67MET0.97373437
68PLK20.95202535
69DYRK30.94130742
70TTK0.93234664
71EPHB10.92926265
72BRD40.91087357
73GRK60.90672590
74CLK10.90396164
75PRKCE0.88799339
76MAPK130.88613380
77MOS0.86783079
78CDK40.86178889
79SGK30.85911105
80PAK60.84677119
81PNCK0.82806994
82MELK0.80174650
83PIK3CG0.78525930
84ADRBK10.78168842
85MARK10.78155634
86PAK40.77038876
87EIF2AK20.76878737
88PAK30.76304768
89IKBKE0.76021482
90CSNK1G20.75885812
91TNIK0.75679040
92CCNB10.74480083
93MAP2K70.74455609
94MAP3K40.74056149
95PHKG20.73703987
96PHKG10.73703987
97FGFR30.71062292
98PDK20.70333139
99CDC70.70314933
100PIK3CA0.69565220
101CSNK1A1L0.67635203
102STK110.67186622
103ALK0.66523225
104MARK30.66285914
105TEC0.65949309
106BMPR20.61164524
107FGFR10.61050372
108MTOR0.60849083
109DYRK1A0.58694620
110PLK30.58604669
111CSNK1G10.58298737
112CSNK1E0.58021186
113FER0.57436508
114NLK0.57316394
115EPHA30.57188690
116GSK3A0.56158465
117CHEK10.55707732
118STK100.55477415
119ERN10.54891625
120GSK3B0.54392516
121MAPK100.53589727
122CDK20.53256073
123MAP3K140.52573586
124PDK10.51646980
125ABL20.51112471
126PRKCZ0.50590233
127RPS6KA30.50359535
128MAP2K40.50039370
129CDK60.49882681
130MUSK0.49717227
131SGK2230.49212292
132SGK4940.49212292
133TLK10.48455797
134CDK10.48330353
135TYK20.47887631
136WNK40.47086076
137PTK60.47081723
138CSNK1G30.47076325
139CHEK20.46864253
140CSNK2A20.46542394
141LATS20.46295498
142CAMK40.46197788
143PRKAA20.45683721
144TBK10.45673966
145PDPK10.45471829
146CDK80.43699006
147CDK90.43550235
148PRKCG0.42185911
149VRK10.39388267
150SGK10.39321336
151ABL10.38970256
152KIT0.38617919
153MAPK90.38468478
154CHUK0.38266026
155CDK70.38052297
156ATM0.37698101
157ROCK20.37543928
158CAMK2A0.37307638
159ROCK10.37200577
160PRKCQ0.37048559
161IGF1R0.34635228
162GRK50.32146365
163PRKACA0.31856433
164ITK0.28973242
165FLT30.28607679
166EIF2AK10.27516231
167PIM10.26945702

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48602007
2Nitrogen metabolism_Homo sapiens_hsa009103.45950323
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38331469
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.08468847
5Arginine biosynthesis_Homo sapiens_hsa002203.03328657
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.78476290
7Protein export_Homo sapiens_hsa030602.77218787
8Phototransduction_Homo sapiens_hsa047442.69569923
9Fatty acid degradation_Homo sapiens_hsa000712.61971171
10Butanoate metabolism_Homo sapiens_hsa006502.55872620
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55073264
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43914652
13Basal transcription factors_Homo sapiens_hsa030222.36584454
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34602769
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28935872
16Tryptophan metabolism_Homo sapiens_hsa003802.28568763
17Complement and coagulation cascades_Homo sapiens_hsa046102.25500417
18Steroid biosynthesis_Homo sapiens_hsa001002.20018149
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13861562
20Regulation of autophagy_Homo sapiens_hsa041402.13323457
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.11906732
22PPAR signaling pathway_Homo sapiens_hsa033202.10089659
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08434010
24Fatty acid metabolism_Homo sapiens_hsa012122.07165710
25RNA degradation_Homo sapiens_hsa030182.00591175
26Vitamin B6 metabolism_Homo sapiens_hsa007501.99547387
27Linoleic acid metabolism_Homo sapiens_hsa005911.93911806
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92807073
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90461408
30Propanoate metabolism_Homo sapiens_hsa006401.89794207
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83907515
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83667221
33Bile secretion_Homo sapiens_hsa049761.76931384
34Fanconi anemia pathway_Homo sapiens_hsa034601.76668328
35Biosynthesis of amino acids_Homo sapiens_hsa012301.74434369
36Peroxisome_Homo sapiens_hsa041461.71305456
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69743515
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52419531
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49791871
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48962379
41Fatty acid biosynthesis_Homo sapiens_hsa000611.48015218
42Lysine degradation_Homo sapiens_hsa003101.44094194
43Homologous recombination_Homo sapiens_hsa034401.42983218
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40864069
45Nicotine addiction_Homo sapiens_hsa050331.38604539
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.36133486
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34001885
48Chemical carcinogenesis_Homo sapiens_hsa052041.33574163
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.32217309
50Oxidative phosphorylation_Homo sapiens_hsa001901.31968248
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31671779
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.29964866
53Staphylococcus aureus infection_Homo sapiens_hsa051501.25110701
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24566939
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24199106
56Carbon metabolism_Homo sapiens_hsa012001.24017661
57Selenocompound metabolism_Homo sapiens_hsa004501.14190062
58Fat digestion and absorption_Homo sapiens_hsa049751.13479588
59Sulfur metabolism_Homo sapiens_hsa009201.11262755
60Rheumatoid arthritis_Homo sapiens_hsa053231.09453493
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.05881916
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04732810
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04562252
64beta-Alanine metabolism_Homo sapiens_hsa004101.03252568
65Olfactory transduction_Homo sapiens_hsa047401.02514331
66Retinol metabolism_Homo sapiens_hsa008301.02035891
67Legionellosis_Homo sapiens_hsa051341.00128023
68Pyruvate metabolism_Homo sapiens_hsa006200.99981163
69ABC transporters_Homo sapiens_hsa020100.98326466
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.97395204
71Phenylalanine metabolism_Homo sapiens_hsa003600.95697441
72Parkinsons disease_Homo sapiens_hsa050120.94089364
73Insulin resistance_Homo sapiens_hsa049310.92009225
74Fatty acid elongation_Homo sapiens_hsa000620.91924519
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.91428917
76Glycerolipid metabolism_Homo sapiens_hsa005610.91176402
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.91162534
78Taste transduction_Homo sapiens_hsa047420.90681368
79Histidine metabolism_Homo sapiens_hsa003400.90418988
80Asthma_Homo sapiens_hsa053100.88388125
81Starch and sucrose metabolism_Homo sapiens_hsa005000.86397247
82Dorso-ventral axis formation_Homo sapiens_hsa043200.86377084
83Collecting duct acid secretion_Homo sapiens_hsa049660.84120709
84Type I diabetes mellitus_Homo sapiens_hsa049400.83725568
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82023005
86Vitamin digestion and absorption_Homo sapiens_hsa049770.80887126
87TNF signaling pathway_Homo sapiens_hsa046680.79791858
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76690391
89Tyrosine metabolism_Homo sapiens_hsa003500.76060318
90Arginine and proline metabolism_Homo sapiens_hsa003300.75400792
91Serotonergic synapse_Homo sapiens_hsa047260.75107996
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.74257939
93Folate biosynthesis_Homo sapiens_hsa007900.71546567
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70339730
95Mineral absorption_Homo sapiens_hsa049780.70022406
96Graft-versus-host disease_Homo sapiens_hsa053320.69417654
97Non-homologous end-joining_Homo sapiens_hsa034500.69030945
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67918737
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67849905
100Calcium signaling pathway_Homo sapiens_hsa040200.66798267
101Cardiac muscle contraction_Homo sapiens_hsa042600.66530385
102Morphine addiction_Homo sapiens_hsa050320.66445500
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65634118
104One carbon pool by folate_Homo sapiens_hsa006700.62386342
105TGF-beta signaling pathway_Homo sapiens_hsa043500.60535236
106Pentose phosphate pathway_Homo sapiens_hsa000300.60464851
107Sphingolipid metabolism_Homo sapiens_hsa006000.59851095
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57206229
109African trypanosomiasis_Homo sapiens_hsa051430.56464976
110Long-term depression_Homo sapiens_hsa047300.56336894
111p53 signaling pathway_Homo sapiens_hsa041150.56186312
112Alzheimers disease_Homo sapiens_hsa050100.54295513
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53170752
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52503330
115mTOR signaling pathway_Homo sapiens_hsa041500.52450160
116Salivary secretion_Homo sapiens_hsa049700.51752356
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51488740
118Nucleotide excision repair_Homo sapiens_hsa034200.51068967
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.49671309
120Circadian entrainment_Homo sapiens_hsa047130.48972372
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48631260
122Oxytocin signaling pathway_Homo sapiens_hsa049210.48568840
123AMPK signaling pathway_Homo sapiens_hsa041520.48111645
124Glucagon signaling pathway_Homo sapiens_hsa049220.46953011
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46445657
126Huntingtons disease_Homo sapiens_hsa050160.45621584
127Allograft rejection_Homo sapiens_hsa053300.44416880
128Insulin secretion_Homo sapiens_hsa049110.43784548
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43540702
130Caffeine metabolism_Homo sapiens_hsa002320.42955210
131Proteasome_Homo sapiens_hsa030500.42600182
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41896204
133Measles_Homo sapiens_hsa051620.41467590
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41181316
135Choline metabolism in cancer_Homo sapiens_hsa052310.38543191
136MAPK signaling pathway_Homo sapiens_hsa040100.38464290
137Renal cell carcinoma_Homo sapiens_hsa052110.37759554
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37673966
139Dopaminergic synapse_Homo sapiens_hsa047280.37654499
140Sulfur relay system_Homo sapiens_hsa041220.36718051
141Primary immunodeficiency_Homo sapiens_hsa053400.36662198
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34390385
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.34221373
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33903461
145cAMP signaling pathway_Homo sapiens_hsa040240.32885794
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32835080
147Cocaine addiction_Homo sapiens_hsa050300.31079897
148Prion diseases_Homo sapiens_hsa050200.28233396
149Prostate cancer_Homo sapiens_hsa052150.28135260
150Circadian rhythm_Homo sapiens_hsa047100.27251301
151RNA polymerase_Homo sapiens_hsa030200.25429654
152Type II diabetes mellitus_Homo sapiens_hsa049300.25191640
153Metabolic pathways_Homo sapiens_hsa011000.24572724
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21890897
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21334512
156Axon guidance_Homo sapiens_hsa043600.19822293
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18811030
158MicroRNAs in cancer_Homo sapiens_hsa052060.15694063
159FoxO signaling pathway_Homo sapiens_hsa040680.15218347
160Glutamatergic synapse_Homo sapiens_hsa047240.11737113
161mRNA surveillance pathway_Homo sapiens_hsa030150.11079698
162Ether lipid metabolism_Homo sapiens_hsa005650.08793830
163Hippo signaling pathway_Homo sapiens_hsa043900.07204742
164GABAergic synapse_Homo sapiens_hsa047270.07034911
165Ovarian steroidogenesis_Homo sapiens_hsa049130.05724015
166Insulin signaling pathway_Homo sapiens_hsa049100.05233930
167Basal cell carcinoma_Homo sapiens_hsa052170.02516548
168Inositol phosphate metabolism_Homo sapiens_hsa005620.01997638
169Adherens junction_Homo sapiens_hsa045200.01960753

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