ZBTB45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.18217246
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.23181547
3proline metabolic process (GO:0006560)6.01608690
4positive regulation of protein homooligomerization (GO:0032464)5.81463166
5transcription from mitochondrial promoter (GO:0006390)5.75845095
6axon ensheathment in central nervous system (GO:0032291)5.43610003
7central nervous system myelination (GO:0022010)5.43610003
8replication fork processing (GO:0031297)5.38801247
9protein neddylation (GO:0045116)4.99907051
10embryonic process involved in female pregnancy (GO:0060136)4.78058351
11cellular response to ATP (GO:0071318)4.76630379
12DNA deamination (GO:0045006)4.69593389
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.62092841
14UV protection (GO:0009650)4.57747962
15protein retention in ER lumen (GO:0006621)4.47817138
16protein insertion into membrane (GO:0051205)4.43460326
17negative regulation of cell size (GO:0045792)4.41511350
18regulation of protein homooligomerization (GO:0032462)4.29770094
19poly(A)+ mRNA export from nucleus (GO:0016973)4.29099174
20peptidyl-arginine omega-N-methylation (GO:0035247)4.21413395
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.18979809
22positive regulation of developmental pigmentation (GO:0048087)4.08614597
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.07877945
24oxidative demethylation (GO:0070989)4.06270491
25negative regulation of erythrocyte differentiation (GO:0045647)4.05915508
26regulation of mammary gland epithelial cell proliferation (GO:0033599)4.01973234
27positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.00678909
28establishment of apical/basal cell polarity (GO:0035089)3.96816701
29DNA ligation (GO:0006266)3.90618028
30DNA integration (GO:0015074)3.89570231
31negative regulation of DNA-templated transcription, elongation (GO:0032785)3.84712615
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.84712615
33negative regulation of heart rate (GO:0010459)3.76391593
34nuclear envelope reassembly (GO:0031468)3.73761811
35mitotic nuclear envelope reassembly (GO:0007084)3.73761811
36DNA double-strand break processing (GO:0000729)3.70342343
37pentose metabolic process (GO:0019321)3.69712612
38COPI coating of Golgi vesicle (GO:0048205)3.69386196
39Golgi transport vesicle coating (GO:0048200)3.69386196
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68399171
41DNA strand renaturation (GO:0000733)3.68358337
42regulation of integrin activation (GO:0033623)3.67465712
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67108457
44negative regulation of JAK-STAT cascade (GO:0046426)3.65237080
45lateral sprouting from an epithelium (GO:0060601)3.65049332
46viral mRNA export from host cell nucleus (GO:0046784)3.63453258
47mitochondrial DNA metabolic process (GO:0032042)3.62144171
48intracellular estrogen receptor signaling pathway (GO:0030520)3.62060370
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.60589403
50neuron cell-cell adhesion (GO:0007158)3.56763950
51establishment of monopolar cell polarity (GO:0061162)3.53781041
52establishment or maintenance of monopolar cell polarity (GO:0061339)3.53781041
53positive regulation of DNA-templated transcription, elongation (GO:0032786)3.52988757
54pentose-phosphate shunt (GO:0006098)3.52790625
55regulation of mitochondrial depolarization (GO:0051900)3.52294642
56positive regulation of DNA repair (GO:0045739)3.49368262
57glial cell migration (GO:0008347)3.43098342
58positive regulation by host of viral transcription (GO:0043923)3.39270593
59peptidyl-arginine N-methylation (GO:0035246)3.38005915
60peptidyl-arginine methylation (GO:0018216)3.38005915
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.34604919
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34604919
63pyrimidine-containing compound salvage (GO:0008655)3.33061240
64pyrimidine nucleoside salvage (GO:0043097)3.33061240
65negative regulation of response to food (GO:0032096)3.32858858
66negative regulation of appetite (GO:0032099)3.32858858
67ribosomal small subunit biogenesis (GO:0042274)3.32608026
68face development (GO:0060324)3.30710003
69auditory receptor cell stereocilium organization (GO:0060088)3.28580589
70negative regulation of cell cycle arrest (GO:0071157)3.27344042
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27221267
72glucose catabolic process (GO:0006007)3.25256250
73apoptotic process involved in morphogenesis (GO:0060561)3.24008708
74negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.23854909
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21312111
76regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.20787645
77positive regulation of protein sumoylation (GO:0033235)3.20318506
78barbed-end actin filament capping (GO:0051016)3.19517134
79protein maturation by protein folding (GO:0022417)3.18504051
80nucleotide salvage (GO:0043173)3.17871046
81enteric nervous system development (GO:0048484)3.17227686
82keratinocyte development (GO:0003334)3.16565063
83glycerophospholipid catabolic process (GO:0046475)3.14977355
84histone arginine methylation (GO:0034969)3.12970416
85metallo-sulfur cluster assembly (GO:0031163)3.11901216
86iron-sulfur cluster assembly (GO:0016226)3.11901216
87negative regulation of Notch signaling pathway (GO:0045746)3.11275383
88presynaptic membrane assembly (GO:0097105)3.09377448
89cell-cell junction maintenance (GO:0045217)3.09270560
90ensheathment of neurons (GO:0007272)3.07743390
91axon ensheathment (GO:0008366)3.07743390
92cullin deneddylation (GO:0010388)3.07252396
93negative regulation of Ras GTPase activity (GO:0034261)3.05336454
94respiratory system process (GO:0003016)3.04978930
95rRNA transcription (GO:0009303)3.04891769
96adenosine receptor signaling pathway (GO:0001973)3.04639341
973-UTR-mediated mRNA stabilization (GO:0070935)3.04346064
98long-chain fatty acid biosynthetic process (GO:0042759)3.03520737
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03112493
100myelination (GO:0042552)3.02845122
101positive regulation of histone deacetylation (GO:0031065)3.01292022
102cell migration in hindbrain (GO:0021535)2.97204973
103regulation of transmission of nerve impulse (GO:0051969)2.96010342
104pyrimidine nucleotide catabolic process (GO:0006244)2.93571279
105modulation by virus of host process (GO:0019054)2.93501663
106transmission of nerve impulse (GO:0019226)2.93493561
107regulation of respiratory system process (GO:0044065)2.91747062
108regulation of protein sumoylation (GO:0033233)2.91286246
109positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.90162957
110semaphorin-plexin signaling pathway (GO:0071526)2.88836119
111regulation of cAMP-dependent protein kinase activity (GO:2000479)2.87862373
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87288551
113adenine nucleotide transport (GO:0051503)2.86922271
114embryonic camera-type eye development (GO:0031076)2.86086201
115presynaptic membrane organization (GO:0097090)2.85606592
116purine deoxyribonucleotide catabolic process (GO:0009155)2.84580397
117viral transcription (GO:0019083)2.84507141
118sphingomyelin metabolic process (GO:0006684)2.83706453
119response to peptidoglycan (GO:0032494)2.83561451
120NADPH regeneration (GO:0006740)2.81363161
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.80524694
122convergent extension (GO:0060026)2.79709447
123head development (GO:0060322)2.79042260
124GDP-mannose metabolic process (GO:0019673)2.77510346
125regulation of NFAT protein import into nucleus (GO:0051532)2.77036831
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76228754
127positive regulation of odontogenesis (GO:0042482)2.76061188
128mannose metabolic process (GO:0006013)2.75900531
129positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.74786680
130negative regulation of tumor necrosis factor production (GO:0032720)2.74752457
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73912429
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73639872
133positive regulation of circadian rhythm (GO:0042753)2.72871089
134nucleosome disassembly (GO:0006337)2.72801800
135protein-DNA complex disassembly (GO:0032986)2.72801800
136epithelial cilium movement (GO:0003351)2.71828160
137positive regulation of TOR signaling (GO:0032008)2.71357165
138cellular response to virus (GO:0098586)2.71305148
139deoxyribonucleotide catabolic process (GO:0009264)2.71227923
140stress fiber assembly (GO:0043149)2.70716857
141snRNA metabolic process (GO:0016073)2.70193284
142positive regulation of protein kinase C signaling (GO:0090037)2.69383535
143spinal cord development (GO:0021510)2.69213403
144fatty acid elongation (GO:0030497)2.69162284
145activation of NF-kappaB-inducing kinase activity (GO:0007250)2.68784074
146virion assembly (GO:0019068)2.68686772
147single strand break repair (GO:0000012)2.68672064
148establishment of mitochondrion localization (GO:0051654)2.68543882
149base-excision repair, AP site formation (GO:0006285)2.68348203
150modulation by symbiont of host cellular process (GO:0044068)2.67808500
151negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.66555028
152chaperone mediated protein folding requiring cofactor (GO:0051085)2.66489143
153positive regulation of amino acid transport (GO:0051957)2.66269360
154regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.65988913
155protein localization to endosome (GO:0036010)2.65739426
156cholesterol biosynthetic process (GO:0006695)2.65510292
157phosphatidylglycerol biosynthetic process (GO:0006655)2.65151434
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64604787
159regulation of collateral sprouting (GO:0048670)2.64600525
160regulation of glutamate secretion (GO:0014048)2.62835951
161positive regulation of microtubule polymerization (GO:0031116)2.62810917
162maturation of 5.8S rRNA (GO:0000460)2.62633052
163negative regulation of neurotransmitter secretion (GO:0046929)2.61537009
164astrocyte development (GO:0014002)2.61059103
165translational termination (GO:0006415)2.60596331
166folic acid metabolic process (GO:0046655)2.60590641
167retrograde transport, endosome to Golgi (GO:0042147)2.60566791
168inner ear receptor stereocilium organization (GO:0060122)2.59886127
169membrane assembly (GO:0071709)2.59812548
170mitotic cell cycle arrest (GO:0071850)2.59786069
171neuron fate specification (GO:0048665)2.59206226
172response to misfolded protein (GO:0051788)2.59116643
173nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58923372
174modulation by virus of host morphology or physiology (GO:0019048)2.58795722
175glucose 6-phosphate metabolic process (GO:0051156)2.58569475
176telomere maintenance via semi-conservative replication (GO:0032201)2.56662842
177regulation of autophagic vacuole assembly (GO:2000785)2.56326183
178mitochondrial calcium ion transport (GO:0006851)2.54508066
179negative regulation of microtubule polymerization (GO:0031115)2.54320477
180purine ribonucleotide transport (GO:0015868)2.52084078
181activation of MAPKKK activity (GO:0000185)2.51814634
182negative regulation of interleukin-2 production (GO:0032703)2.49573540
183peptidyl-tyrosine autophosphorylation (GO:0038083)2.49033711
184mitochondrial fusion (GO:0008053)2.48066072
185regulation of monocyte differentiation (GO:0045655)2.46841809
186regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45644733
187misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.45521368
188post-embryonic morphogenesis (GO:0009886)2.44666304
189dosage compensation (GO:0007549)2.43951499
190peptidyl-proline hydroxylation (GO:0019511)2.43675409
191maternal placenta development (GO:0001893)2.42990918
192endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41663928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.24109798
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.24109798
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.24109798
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.44691193
5VDR_21846776_ChIP-Seq_THP-1_Human3.39222879
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99844048
7LXR_22292898_ChIP-Seq_THP-1_Human2.84940084
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.81697912
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.61146534
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.49962076
11MYC_22102868_ChIP-Seq_BL_Human2.44095400
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42118508
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.39040916
14EZH2_22144423_ChIP-Seq_EOC_Human2.38210449
15* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37926044
16VDR_22108803_ChIP-Seq_LS180_Human2.33334577
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.32018236
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.23279577
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.22874763
20POU5F1_16518401_ChIP-PET_MESCs_Mouse2.19236810
21TCF3_18692474_ChIP-Seq_MESCs_Mouse2.15591920
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.13765607
23P68_20966046_ChIP-Seq_HELA_Human2.10403717
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10296946
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10030760
26RACK7_27058665_Chip-Seq_MCF-7_Human2.08123353
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03275061
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00487808
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.95137015
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93660834
31KDM2B_26808549_Chip-Seq_DND41_Human1.93003456
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92954745
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.89611495
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88147939
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87544272
36RNF2_27304074_Chip-Seq_NSC_Mouse1.86630142
37ZNF263_19887448_ChIP-Seq_K562_Human1.85126075
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84541658
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83022408
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80959280
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.77895630
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.77595014
43XRN2_22483619_ChIP-Seq_HELA_Human1.75764513
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75327029
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.69064158
46BCL6_27268052_Chip-Seq_Bcells_Human1.67942051
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66256031
48* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66037395
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65772798
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.65585605
51VDR_24763502_ChIP-Seq_THP-1_Human1.65562444
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.65274012
53MAF_26560356_Chip-Seq_TH2_Human1.64494936
54* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64057054
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.62303888
56* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.60774270
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60020457
58TCF7_22412390_ChIP-Seq_EML_Mouse1.59886175
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.59872462
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58805360
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57810183
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56405127
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56166937
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.55866921
65BCOR_27268052_Chip-Seq_Bcells_Human1.54936695
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52903319
67SMC4_20622854_ChIP-Seq_HELA_Human1.52518100
68MAF_26560356_Chip-Seq_TH1_Human1.48234670
69UTX_26944678_Chip-Seq_JUKART_Human1.45169542
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44164332
71NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42926825
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41952596
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41319914
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40110788
75PHF8_20622854_ChIP-Seq_HELA_Human1.39231143
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38509549
77KDM2B_26808549_Chip-Seq_K562_Human1.37805528
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36959381
79CREB1_26743006_Chip-Seq_LNCaP_Human1.36237572
80REST_21632747_ChIP-Seq_MESCs_Mouse1.35360485
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34548465
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.34067812
83AR_21572438_ChIP-Seq_LNCaP_Human1.33579760
84IRF1_19129219_ChIP-ChIP_H3396_Human1.32970105
85* CTCF_21964334_Chip-Seq_Bcells_Human1.32641110
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32269786
87CIITA_25753668_ChIP-Seq_RAJI_Human1.31798396
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.31612034
89E2F1_20622854_ChIP-Seq_HELA_Human1.31433965
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31104620
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30224883
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29723637
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29652136
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29244644
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29152591
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28770495
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.28085415
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27950404
99* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27591674
100TP53_22127205_ChIP-Seq_IMR90_Human1.27398569
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.26301198
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26279570
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26116399
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.25597975
105NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24987196
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24576501
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24485711
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23505890
109GABP_19822575_ChIP-Seq_HepG2_Human1.23153319
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22976238
111* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22828412
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22003405
113* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21936109
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21825173
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.21687981
116STAT1_20625510_ChIP-Seq_HELA_Human1.21607877
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21177508
118* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20723687
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.20683911
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20250987
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.19697732
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.18392491
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.18215972
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16887386
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15873454
126* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15193987
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15184069
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14890571
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14415964
130NCOR1_26117541_ChIP-Seq_K562_Human1.14254558
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13604882
132* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13392073
133CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13360048
134MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13239394
135PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12485010
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11794212
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11521113
138YY1_22570637_ChIP-Seq_MALME-3M_Human1.10518073
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10443858
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10268405
141CTCF_20526341_ChIP-Seq_ESCs_Human1.10186418
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10125234
143ATF3_27146783_Chip-Seq_COLON_Human1.09806635
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08961534
145RUNX1_22412390_ChIP-Seq_EML_Mouse1.08669548
146ETS1_21867929_ChIP-Seq_TH2_Mouse1.08517907
147ESR2_21235772_ChIP-Seq_MCF-7_Human1.07900802
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07438662
149SA1_27219007_Chip-Seq_Bcells_Human1.07326399
150GABP_17652178_ChIP-ChIP_JURKAT_Human1.06705619
151POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06293194
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05597310
153FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04312904
154HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04089410
155TAF15_26573619_Chip-Seq_HEK293_Human1.03689600
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03488373
157* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00825571
158SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00600477
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00417041
160KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99784862
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99708216
162* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99676718
163EST1_17652178_ChIP-ChIP_JURKAT_Human0.99319007
164RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99242391
165EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99242391
166* CTCF_27219007_Chip-Seq_Bcells_Human0.97743530
167* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96046761
168FUS_26573619_Chip-Seq_HEK293_Human0.95997271
169* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95924172
170NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95410607
171SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95320250
172P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95032184
173SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94984347
174STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94524985
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94457379
176RING1B_27294783_Chip-Seq_ESCs_Mouse0.94260623
177CDX2_20551321_ChIP-Seq_CACO-2_Human0.92643615
178NANOG_16518401_ChIP-PET_MESCs_Mouse0.91586134
179NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91574923
180ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91283807
181SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91255009
182TRIM28_21343339_ChIP-Seq_HEK293_Human0.89248688
183PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87873909
184NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87456338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.74865680
2MP0008057_abnormal_DNA_replication5.12546016
3MP0005451_abnormal_body_composition4.56778983
4MP0003136_yellow_coat_color4.06978675
5MP0004858_abnormal_nervous_system4.05148661
6MP0005058_abnormal_lysosome_morphology3.86997831
7MP0003880_abnormal_central_pattern3.72312501
8MP0005645_abnormal_hypothalamus_physiol3.61690938
9MP0002009_preneoplasia3.58413693
10MP0003705_abnormal_hypodermis_morpholog3.20087327
11MP0005083_abnormal_biliary_tract2.62411997
12MP0005423_abnormal_somatic_nervous2.57235276
13MP0001849_ear_inflammation2.49490956
14MP0009840_abnormal_foam_cell2.44303598
15MP0000751_myopathy2.38005751
16MP0006072_abnormal_retinal_apoptosis2.36406053
17MP0008995_early_reproductive_senescence2.26247960
18MP0000750_abnormal_muscle_regeneration2.14363738
19MP0009278_abnormal_bone_marrow2.11173681
20MP0004133_heterotaxia2.08251881
21MP0005397_hematopoietic_system_phenotyp2.07058624
22MP0001545_abnormal_hematopoietic_system2.07058624
23MP0000678_abnormal_parathyroid_gland2.06881011
24MP0008260_abnormal_autophagy2.06413227
25MP0010030_abnormal_orbit_morphology2.05609565
26MP0004142_abnormal_muscle_tone2.03382452
27MP0003123_paternal_imprinting2.00069896
28MP0004381_abnormal_hair_follicle1.95316672
29MP0000462_abnormal_digestive_system1.89615182
30MP0003806_abnormal_nucleotide_metabolis1.88349812
31MP0005174_abnormal_tail_pigmentation1.86178516
32MP0003172_abnormal_lysosome_physiology1.82919800
33MP0003890_abnormal_embryonic-extraembry1.80096726
34MP0002249_abnormal_larynx_morphology1.74103139
35MP0003436_decreased_susceptibility_to1.72389393
36MP0002822_catalepsy1.72257859
37MP0000778_abnormal_nervous_system1.70813711
38MP0009046_muscle_twitch1.70400045
39MP0005501_abnormal_skin_physiology1.68735729
40MP0003303_peritoneal_inflammation1.68394266
41MP0003453_abnormal_keratinocyte_physiol1.62123192
42MP0005409_darkened_coat_color1.61785089
43MP0006292_abnormal_olfactory_placode1.61028093
44MP0005076_abnormal_cell_differentiation1.59492836
45MP0005330_cardiomyopathy1.52829175
46MP0002064_seizures1.51768716
47MP0001529_abnormal_vocalization1.51377436
48MP0000762_abnormal_tongue_morphology1.48801559
49MP0000747_muscle_weakness1.47450937
50MP0005075_abnormal_melanosome_morpholog1.46471441
51MP0004185_abnormal_adipocyte_glucose1.39446368
52MP0002572_abnormal_emotion/affect_behav1.39281713
53MP0002272_abnormal_nervous_system1.39214314
54MP0002796_impaired_skin_barrier1.38755349
55MP0004947_skin_inflammation1.38246976
56MP0001986_abnormal_taste_sensitivity1.37215822
57MP0002751_abnormal_autonomic_nervous1.36687102
58MP0004145_abnormal_muscle_electrophysio1.33921597
59MP0000003_abnormal_adipose_tissue1.31974941
60MP0005253_abnormal_eye_physiology1.31702844
61MP0003191_abnormal_cellular_cholesterol1.31393093
62MP0002282_abnormal_trachea_morphology1.31291789
63MP0000015_abnormal_ear_pigmentation1.28688535
64MP0004859_abnormal_synaptic_plasticity1.26786955
65MP0001485_abnormal_pinna_reflex1.26434881
66MP0000920_abnormal_myelination1.25142999
67MP0009333_abnormal_splenocyte_physiolog1.25039118
68MP0000579_abnormal_nail_morphology1.24665526
69MP0009379_abnormal_foot_pigmentation1.20905452
70MP0003938_abnormal_ear_development1.20831226
71MP0000759_abnormal_skeletal_muscle1.20762371
72MP0001486_abnormal_startle_reflex1.18703088
73MP0003315_abnormal_perineum_morphology1.18449819
74MP0008932_abnormal_embryonic_tissue1.17152091
75MP0004510_myositis1.15103814
76MP0001970_abnormal_pain_threshold1.14991889
77MP0001340_abnormal_eyelid_morphology1.13799547
78MP0001905_abnormal_dopamine_level1.13261395
79MP0006276_abnormal_autonomic_nervous1.12975123
80MP0004742_abnormal_vestibular_system1.12545991
81MP0002132_abnormal_respiratory_system1.10137826
82MP0003283_abnormal_digestive_organ1.09336993
83MP0001188_hyperpigmentation1.08910334
84MP0000631_abnormal_neuroendocrine_gland1.07692501
85MP0002733_abnormal_thermal_nociception1.05634990
86MP0008877_abnormal_DNA_methylation1.04791458
87MP0003329_amyloid_beta_deposits1.03693411
88MP0001293_anophthalmia1.03321757
89MP0001440_abnormal_grooming_behavior1.03014833
90MP0000538_abnormal_urinary_bladder1.02671505
91MP0000467_abnormal_esophagus_morphology1.02421456
92MP0000026_abnormal_inner_ear1.02236581
93MP0001270_distended_abdomen1.02050109
94MP0003111_abnormal_nucleus_morphology1.01623635
95MP0000490_abnormal_crypts_of1.01499389
96MP0009931_abnormal_skin_appearance1.01391098
97MP0003786_premature_aging1.00866373
98MP0003634_abnormal_glial_cell1.00738323
99MP0009745_abnormal_behavioral_response1.00572853
100MP0005375_adipose_tissue_phenotype1.00424930
101MP0000639_abnormal_adrenal_gland1.00188970
102MP0002752_abnormal_somatic_nervous1.00188857
103MP0002089_abnormal_postnatal_growth/wei0.99877348
104MP0005551_abnormal_eye_electrophysiolog0.99575889
105MP0000858_altered_metastatic_potential0.99532560
106MP0003718_maternal_effect0.99498712
107MP0003385_abnormal_body_wall0.99258326
108MP0000465_gastrointestinal_hemorrhage0.98883261
109MP0003635_abnormal_synaptic_transmissio0.98315584
110MP0000470_abnormal_stomach_morphology0.97204653
111MP0000955_abnormal_spinal_cord0.96826126
112MP0001348_abnormal_lacrimal_gland0.96546888
113MP0000537_abnormal_urethra_morphology0.96114713
114MP0000733_abnormal_muscle_development0.96104132
115MP0000358_abnormal_cell_content/0.95866123
116MP0008874_decreased_physiological_sensi0.95065324
117MP0002882_abnormal_neuron_morphology0.94139023
118MP0004233_abnormal_muscle_weight0.94001690
119MP0002063_abnormal_learning/memory/cond0.93605243
120MP0003075_altered_response_to0.93301499
121MP0001661_extended_life_span0.92908785
122MP0003279_aneurysm0.92241542
123MP0005025_abnormal_response_to0.90980510
124MP0001873_stomach_inflammation0.90545243
125MP0002067_abnormal_sensory_capabilities0.90397403
126MP0006035_abnormal_mitochondrial_morpho0.89749192
127MP0002332_abnormal_exercise_endurance0.89742131
128MP0003755_abnormal_palate_morphology0.89721354
129MP0005464_abnormal_platelet_physiology0.89506709
130MP0005394_taste/olfaction_phenotype0.87495625
131MP0005499_abnormal_olfactory_system0.87495625
132MP0005195_abnormal_posterior_eye0.86153704
133MP0005666_abnormal_adipose_tissue0.85186258
134MP0001324_abnormal_eye_pigmentation0.83943183
135MP0003119_abnormal_digestive_system0.83772737
136MP0002938_white_spotting0.82847092
137MP0005623_abnormal_meninges_morphology0.82337568
138MP0009384_cardiac_valve_regurgitation0.81749400
139MP0002066_abnormal_motor_capabilities/c0.80340835
140MP0001963_abnormal_hearing_physiology0.78997736
141MP0005391_vision/eye_phenotype0.78697008
142MP0000049_abnormal_middle_ear0.78665996
143MP0002163_abnormal_gland_morphology0.78530017
144MP0003690_abnormal_glial_cell0.78042010
145MP0001502_abnormal_circadian_rhythm0.77466605
146MP0003693_abnormal_embryo_hatching0.77285795
147MP0008058_abnormal_DNA_repair0.76611154
148MP0002148_abnormal_hypersensitivity_rea0.76209838
149MP0003566_abnormal_cell_adhesion0.75324089
150MP0003638_abnormal_response/metabolism_0.74914653
151MP0003137_abnormal_impulse_conducting0.74289832
152MP0000681_abnormal_thyroid_gland0.73232672
153MP0002557_abnormal_social/conspecific_i0.73189731
154MP0003763_abnormal_thymus_physiology0.72048115
155MP0004134_abnormal_chest_morphology0.71374417
156MP0002184_abnormal_innervation0.70492991
157MP0001346_abnormal_lacrimal_gland0.68967538
158MP0001968_abnormal_touch/_nociception0.68205040
159MP0002429_abnormal_blood_cell0.68002812
160MP0000313_abnormal_cell_death0.67495101
161MP0002277_abnormal_respiratory_mucosa0.67409051
162MP0002152_abnormal_brain_morphology0.67367400
163MP0008789_abnormal_olfactory_epithelium0.67247400
164MP0005257_abnormal_intraocular_pressure0.66759164
165MP0005379_endocrine/exocrine_gland_phen0.66519367
166MP0001727_abnormal_embryo_implantation0.66151849
167MP0002722_abnormal_immune_system0.65558687
168MP0002653_abnormal_ependyma_morphology0.64042415
169MP0002398_abnormal_bone_marrow0.63658702
170MP0004087_abnormal_muscle_fiber0.63465710
171MP0001216_abnormal_epidermal_layer0.63132698
172MP0002419_abnormal_innate_immunity0.63036223
173MP0002116_abnormal_craniofacial_bone0.62594098
174MP0001664_abnormal_digestion0.61713196
175MP0002114_abnormal_axial_skeleton0.61312954
176MP0006036_abnormal_mitochondrial_physio0.61235719
177MP0003879_abnormal_hair_cell0.60948272
178MP0005220_abnormal_exocrine_pancreas0.59816342
179MP0002877_abnormal_melanocyte_morpholog0.58969129
180MP0002735_abnormal_chemical_nociception0.57796160
181MP0005584_abnormal_enzyme/coenzyme_acti0.57592021
182MP0002080_prenatal_lethality0.57409610
183MP0000343_altered_response_to0.57069567
184MP0000604_amyloidosis0.56285605
185MP0005384_cellular_phenotype0.56076453

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)7.26473369
2Concave nail (HP:0001598)5.22318417
3Breast hypoplasia (HP:0003187)4.72343288
4Testicular atrophy (HP:0000029)4.36430489
5Alacrima (HP:0000522)3.84537738
6Premature skin wrinkling (HP:0100678)3.75825464
7Rib fusion (HP:0000902)3.71619880
8Hypoplastic nipples (HP:0002557)3.68561622
9Conical tooth (HP:0000698)3.66034065
10Anteriorly placed anus (HP:0001545)3.60755399
11Absent hand (HP:0004050)3.58568910
12Thick nail (HP:0001805)3.52597872
13Myopathic facies (HP:0002058)3.47532047
14Ragged-red muscle fibers (HP:0003200)3.44268946
15Hyperacusis (HP:0010780)3.33189035
16Abnormal hemoglobin (HP:0011902)3.31610254
17Rectal fistula (HP:0100590)3.30294667
18Rectovaginal fistula (HP:0000143)3.30294667
19Abnormality of incisor morphology (HP:0011063)3.26507232
20Distal upper limb amyotrophy (HP:0007149)3.16719483
21Upper limb amyotrophy (HP:0009129)3.16719483
22Coronal craniosynostosis (HP:0004440)3.11283991
23Thin bony cortex (HP:0002753)3.08713331
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.06326998
25Decreased lacrimation (HP:0000633)3.04782098
26Supernumerary ribs (HP:0005815)2.96650705
27Hypochromic microcytic anemia (HP:0004840)2.93490849
28Supernumerary bones of the axial skeleton (HP:0009144)2.89909805
29Abnormal respiratory epithelium morphology (HP:0012253)2.84298245
30Abnormal respiratory motile cilium morphology (HP:0005938)2.84298245
31Absent radius (HP:0003974)2.83116668
32Hand muscle atrophy (HP:0009130)2.82795008
33Ankle clonus (HP:0011448)2.79986084
34Facial hemangioma (HP:0000329)2.76914988
35Hypotrichosis (HP:0001006)2.75841238
36Vaginal fistula (HP:0004320)2.75815998
37Achilles tendon contracture (HP:0001771)2.71956599
38Aplasia involving forearm bones (HP:0009822)2.71031575
39Absent forearm bone (HP:0003953)2.71031575
40Abnormality of polysaccharide metabolism (HP:0011012)2.70638719
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70638719
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70638719
43Long palpebral fissure (HP:0000637)2.70210610
44Alopecia of scalp (HP:0002293)2.69721988
45Narrow nasal bridge (HP:0000446)2.67951964
46IgA deficiency (HP:0002720)2.66643230
47Atonic seizures (HP:0010819)2.64357033
48Intestinal fistula (HP:0100819)2.62512029
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.62215154
50Parakeratosis (HP:0001036)2.62034091
51Increased muscle lipid content (HP:0009058)2.58926710
52Amelogenesis imperfecta (HP:0000705)2.58107017
53Difficulty climbing stairs (HP:0003551)2.57446968
54Vertebral compression fractures (HP:0002953)2.57401161
55Abnormality of male internal genitalia (HP:0000022)2.56503367
56Joint stiffness (HP:0001387)2.54417316
57Hypertensive crisis (HP:0100735)2.53940308
58Abnormality of the axillary hair (HP:0100134)2.53744182
59Abnormality of secondary sexual hair (HP:0009888)2.53744182
60Intestinal atresia (HP:0011100)2.50722101
61Annular pancreas (HP:0001734)2.48060349
62Aplasia of the musculature (HP:0100854)2.47806143
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.46408163
64Urinary glycosaminoglycan excretion (HP:0003541)2.46330697
65Mucopolysacchariduria (HP:0008155)2.46330697
66Squamous cell carcinoma (HP:0002860)2.46233076
67Thoracic kyphosis (HP:0002942)2.46121247
68Ulnar bowing (HP:0003031)2.45862797
69Abnormality of the labia minora (HP:0012880)2.38282244
70Hypoplasia of the ulna (HP:0003022)2.37020968
71Stridor (HP:0010307)2.36928132
72Dysostosis multiplex (HP:0000943)2.35715545
73Abnormality of the thoracic spine (HP:0100711)2.35101405
74Cervical subluxation (HP:0003308)2.33211241
75Aplasia/hypoplasia of the humerus (HP:0006507)2.32928931
76Short chin (HP:0000331)2.32360447
77Progressive muscle weakness (HP:0003323)2.31915654
78Pustule (HP:0200039)2.31775824
79Neonatal onset (HP:0003623)2.30739866
80Petechiae (HP:0000967)2.30674362
81Genu recurvatum (HP:0002816)2.28775747
82Hyperthyroidism (HP:0000836)2.26928895
83Akinesia (HP:0002304)2.25922311
84Hemivertebrae (HP:0002937)2.24326771
85Turricephaly (HP:0000262)2.23232316
86Abnormality of the Achilles tendon (HP:0005109)2.22886400
87Increased cerebral lipofuscin (HP:0011813)2.22260159
88Orthostatic hypotension (HP:0001278)2.21823794
89Easy fatigability (HP:0003388)2.21577188
90Fetal akinesia sequence (HP:0001989)2.21080431
91Broad distal phalanx of finger (HP:0009836)2.19322230
92Abnormal gallbladder physiology (HP:0012438)2.19291769
93Cholecystitis (HP:0001082)2.19291769
94Broad face (HP:0000283)2.18833682
95Short humerus (HP:0005792)2.17778301
96Exercise-induced myalgia (HP:0003738)2.16475758
97Abnormality of the incisor (HP:0000676)2.14144999
98Reticulocytosis (HP:0001923)2.13604501
99Septo-optic dysplasia (HP:0100842)2.13325024
100Abnormality of placental membranes (HP:0011409)2.11502176
101Amniotic constriction ring (HP:0009775)2.11502176
102Abnormality of glycolipid metabolism (HP:0010969)2.10776264
103Abnormality of liposaccharide metabolism (HP:0010968)2.10776264
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.10776264
105Mesangial abnormality (HP:0001966)2.10164118
106J-shaped sella turcica (HP:0002680)2.09817437
107Large for gestational age (HP:0001520)2.08810809
108Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08429825
109Redundant skin (HP:0001582)2.08065853
110Increased intramyocellular lipid droplets (HP:0012240)2.07689730
111Aplasia/Hypoplasia of the ulna (HP:0006495)2.07138771
112Abnormality of the columella (HP:0009929)2.06456411
113Cerebral hypomyelination (HP:0006808)2.04954836
114Prolonged neonatal jaundice (HP:0006579)2.04753903
115Male infertility (HP:0003251)2.03889476
116Cellulitis (HP:0100658)2.02810345
117Increased neuronal autofluorescent lipopigment (HP:0002074)2.01376031
118Duplicated collecting system (HP:0000081)2.00456987
119Ridged nail (HP:0001807)1.98813116
120Peripheral hypomyelination (HP:0007182)1.98661737
121Cholelithiasis (HP:0001081)1.97041170
122Increased connective tissue (HP:0009025)1.96938127
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96454681
124Tongue fasciculations (HP:0001308)1.95667174
125Diminished movement (HP:0002374)1.93542427
126Anophthalmia (HP:0000528)1.93423566
127Popliteal pterygium (HP:0009756)1.93383931
128Acute necrotizing encephalopathy (HP:0006965)1.93208933
129Prostate neoplasm (HP:0100787)1.92858948
130Hypokinesia (HP:0002375)1.92757132
131Tented upper lip vermilion (HP:0010804)1.91637705
132Stenosis of the external auditory canal (HP:0000402)1.91504245
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90439985
134Elbow flexion contracture (HP:0002987)1.90331159
135Choanal stenosis (HP:0000452)1.90055360
136Febrile seizures (HP:0002373)1.89261709
137Spinal rigidity (HP:0003306)1.89054156
138Abnormal number of incisors (HP:0011064)1.87294298
139Asplenia (HP:0001746)1.86686935
140Rough bone trabeculation (HP:0100670)1.86543909
141Obstructive sleep apnea (HP:0002870)1.86276133
142Insomnia (HP:0100785)1.85933270
143Distal lower limb muscle weakness (HP:0009053)1.85735806
144Hypercortisolism (HP:0001578)1.85432603
145Exertional dyspnea (HP:0002875)1.84837216
146Flattened epiphyses (HP:0003071)1.84685348
147Distal lower limb amyotrophy (HP:0008944)1.84367001
148Diaphragmatic weakness (HP:0009113)1.84246347
149Gait imbalance (HP:0002141)1.84244931
150Microvesicular hepatic steatosis (HP:0001414)1.84243372
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83897950
152Neuronal loss in central nervous system (HP:0002529)1.83452762
153Increased variability in muscle fiber diameter (HP:0003557)1.83315126
154Poikiloderma (HP:0001029)1.83059819
155Bulbar palsy (HP:0001283)1.80491954
156Congenital hip dislocation (HP:0001374)1.80216494
157Bifid uvula (HP:0000193)1.79904201
158Atelectasis (HP:0100750)1.79831077
159Generalized amyotrophy (HP:0003700)1.79455508
160Entropion (HP:0000621)1.79308902
161Clumsiness (HP:0002312)1.79282190
162Abnormal ciliary motility (HP:0012262)1.79033668
163Hemorrhage of the eye (HP:0011885)1.78541011
164Abnormal sex determination (HP:0012244)1.78419688
165Sex reversal (HP:0012245)1.78419688
166Absent thumb (HP:0009777)1.78228140
167Progressive microcephaly (HP:0000253)1.78062843
168Ectopic anus (HP:0004397)1.77748687
169Gastrointestinal atresia (HP:0002589)1.77314492
170White forelock (HP:0002211)1.76810805
171Absent septum pellucidum (HP:0001331)1.75972161
172Median cleft lip (HP:0000161)1.75717024
173Medial flaring of the eyebrow (HP:0010747)1.74939789
174Abnormal trabecular bone morphology (HP:0100671)1.74614399
175Asymmetric septal hypertrophy (HP:0001670)1.73930441
176Abnormality of the gallbladder (HP:0005264)1.70781502
177Purpura (HP:0000979)1.70529190
178Gastrointestinal dysmotility (HP:0002579)1.69388686
179Bowed forearm bones (HP:0003956)1.68788908
180Bowing of the arm (HP:0006488)1.68788908
181Loss of speech (HP:0002371)1.68210304
182Pointed chin (HP:0000307)1.67496758
183Retinal dysplasia (HP:0007973)1.67306618
184Self-mutilation (HP:0000742)1.65595154
185Athetosis (HP:0002305)1.64766498
186Increased serum ferritin (HP:0003281)1.63604264
187Elevated alkaline phosphatase (HP:0003155)1.63347577
188Axonal loss (HP:0003447)1.62464345
189Ulnar deviation of the wrist (HP:0003049)1.62443761
190Abnormality of skeletal muscle fiber size (HP:0012084)1.61992779
191Premature rupture of membranes (HP:0001788)1.61508462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.00270170
2MAPK154.85042451
3TRIB33.84568736
4TESK23.82585840
5ERN13.82122116
6MAP3K63.69211779
7DDR23.45206229
8SMG13.13093551
9UHMK13.09184808
10NME22.93786195
11TYRO32.78461718
12SIK12.77760115
13FGR2.66770314
14TNIK2.60662447
15PRKD22.60305543
16TESK12.49097337
17PINK12.34553774
18YES12.23488013
19PRKD32.13891880
20BCKDK2.11814123
21MATK2.08852050
22VRK22.08408239
23ARAF2.07604162
24MAP3K112.01763131
25STK391.90887112
26EEF2K1.83839220
27CASK1.73908619
28CSK1.70225514
29PRPF4B1.63001306
30OXSR11.62043931
31PIM21.61733939
32MAP4K11.52918580
33TNK21.52831228
34MAP2K31.52501815
35SIK21.46371727
36AKT31.45270427
37DAPK11.43708505
38CDK71.36202842
39CDK121.35719074
40TAOK21.29995051
41CAMK2B1.28607176
42MST41.27594083
43TLK11.20940388
44KDR1.18727526
45DYRK21.18366191
46TAOK11.15804741
47DYRK1B1.12890560
48CDK191.12742660
49PKN21.10766081
50RPS6KA21.10653072
51CDC42BPA1.06131559
52BMX1.06010904
53LIMK11.04191602
54TBK11.03431377
55TRPM71.03091306
56IRAK21.00959800
57MARK11.00800128
58MAP3K11.00273191
59PHKG10.99445373
60PHKG20.99445373
61PKN10.98339094
62EPHB10.94741687
63MAP2K70.94440530
64GRK60.94406984
65BCR0.90644571
66RPS6KC10.88960246
67RPS6KL10.88960246
68PDGFRA0.88278746
69CSNK1G10.87382197
70IRAK40.86376100
71MTOR0.84597263
72LATS20.84417072
73CLK10.84414009
74MAPK130.81331290
75MKNK20.80848806
76IKBKB0.80392800
77BLK0.79995384
78GSK3A0.79443830
79SIK30.77867734
80CCNB10.77861564
81CAMK2A0.75347535
82CAMK2D0.75296095
83PAK40.74351677
84TTN0.74312567
85PDPK10.72872268
86MAPK120.72794146
87RPS6KA60.72638337
88LMTK20.72548133
89BRAF0.70665947
90CAMK1D0.69596311
91MAPKAPK30.69436479
92CAMK2G0.69255725
93RIPK10.69216351
94DAPK30.68492492
95NME10.66523302
96IRAK30.65831236
97PNCK0.65432820
98NTRK20.65278557
99EPHA40.64828535
100IRAK10.63753289
101LRRK20.61594896
102LYN0.61339256
103CSNK1G30.60191274
104VRK10.60001930
105FLT30.59869945
106NEK20.58716217
107CHEK20.57603844
108DYRK30.57333470
109PTK60.55670516
110RPS6KB20.55217685
111FES0.55127691
112ADRBK20.54535158
113ROCK20.54164364
114BUB10.53554767
115CDK11A0.53105449
116CSNK1A1L0.53089328
117CAMKK10.53062724
118PIM10.51802355
119PAK10.51782882
120AKT20.49504219
121ZAP700.48647304
122MAP3K100.47055298
123PRKG20.44909831
124CDK180.44504528
125GRK70.44467408
126PRKD10.44216446
127MAP3K80.44195414
128MAP2K60.43924264
129MAP3K30.43895515
130MAP2K20.43832566
131CSNK2A10.42759606
132MAPK110.42499605
133AURKA0.42315604
134CSNK2A20.41559597
135HIPK20.41327020
136CDK40.41103375
137EPHA20.40106529
138MST1R0.39619308
139PTK20.38975545
140MAP3K130.38685621
141PBK0.38505023
142BRSK20.38289478
143STK160.37458279
144MUSK0.36822987
145CDK90.36527983
146BMPR20.35461868
147NTRK30.35159157
148PLK10.34578870
149MKNK10.34325007
150MAPK40.32920731
151CDK60.31436388
152PRKACA0.31024492
153MAPKAPK20.30394157
154MARK20.30069497
155CSF1R0.29783431
156INSR0.29533013
157MOS0.29390320
158ADRBK10.29388139
159SCYL20.29237711
160GRK50.29105155
161ABL20.28482073
162EIF2AK30.28423669
163CDK140.27382833
164RPS6KA10.27307150
165RPS6KB10.27079861
166RAF10.26186384
167CDK150.26142266
168PRKCI0.25877383

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.25124993
2Oxidative phosphorylation_Homo sapiens_hsa001903.59307090
3Ribosome_Homo sapiens_hsa030103.54370773
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.28868700
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.26636116
6Mismatch repair_Homo sapiens_hsa034303.03157574
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.99665722
8Fructose and mannose metabolism_Homo sapiens_hsa000512.91057287
9Other glycan degradation_Homo sapiens_hsa005112.67036730
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61243686
11Parkinsons disease_Homo sapiens_hsa050122.56022762
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.55545305
13Steroid biosynthesis_Homo sapiens_hsa001002.35734585
14Fatty acid elongation_Homo sapiens_hsa000622.28054969
15RNA polymerase_Homo sapiens_hsa030202.26807605
16Base excision repair_Homo sapiens_hsa034102.24586881
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17509540
18Huntingtons disease_Homo sapiens_hsa050162.17333718
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09234864
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05772736
21Alzheimers disease_Homo sapiens_hsa050102.02816700
22Pentose phosphate pathway_Homo sapiens_hsa000301.95538631
23Nicotine addiction_Homo sapiens_hsa050331.91377650
24DNA replication_Homo sapiens_hsa030301.87094739
25Biosynthesis of amino acids_Homo sapiens_hsa012301.84162772
26Protein export_Homo sapiens_hsa030601.80994670
27Lysosome_Homo sapiens_hsa041421.76427163
28Nucleotide excision repair_Homo sapiens_hsa034201.73396716
29Primary immunodeficiency_Homo sapiens_hsa053401.57433422
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57419982
31Spliceosome_Homo sapiens_hsa030401.57118469
32Hedgehog signaling pathway_Homo sapiens_hsa043401.56584633
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53334629
34Fanconi anemia pathway_Homo sapiens_hsa034601.48763118
35Arginine and proline metabolism_Homo sapiens_hsa003301.41424557
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.41051932
37Galactose metabolism_Homo sapiens_hsa000521.38420092
38Collecting duct acid secretion_Homo sapiens_hsa049661.38162523
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.37296032
40Cardiac muscle contraction_Homo sapiens_hsa042601.35744469
41Ether lipid metabolism_Homo sapiens_hsa005651.35319472
42Homologous recombination_Homo sapiens_hsa034401.32209147
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31448244
44Phototransduction_Homo sapiens_hsa047441.27807570
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25328191
46Circadian rhythm_Homo sapiens_hsa047101.24764333
47Endocytosis_Homo sapiens_hsa041441.19936397
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18908433
49mTOR signaling pathway_Homo sapiens_hsa041501.17479618
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.16105273
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.15327695
52Chronic myeloid leukemia_Homo sapiens_hsa052201.14967995
53Axon guidance_Homo sapiens_hsa043601.11636341
54Carbon metabolism_Homo sapiens_hsa012001.08487702
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08186233
56Wnt signaling pathway_Homo sapiens_hsa043101.08080100
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06187161
58Basal transcription factors_Homo sapiens_hsa030221.05881804
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04855299
60Apoptosis_Homo sapiens_hsa042101.03307676
61Serotonergic synapse_Homo sapiens_hsa047261.02733844
62Long-term depression_Homo sapiens_hsa047301.02451380
63AMPK signaling pathway_Homo sapiens_hsa041521.02444257
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01607215
65Glutathione metabolism_Homo sapiens_hsa004801.01283766
66Hippo signaling pathway_Homo sapiens_hsa043900.98434518
67Salmonella infection_Homo sapiens_hsa051320.98150139
68GABAergic synapse_Homo sapiens_hsa047270.98143321
69Non-small cell lung cancer_Homo sapiens_hsa052230.97813680
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97007929
71Phenylalanine metabolism_Homo sapiens_hsa003600.96332690
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96124738
73Basal cell carcinoma_Homo sapiens_hsa052170.95037689
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94065063
75Proteasome_Homo sapiens_hsa030500.91854741
76Notch signaling pathway_Homo sapiens_hsa043300.91194332
77Linoleic acid metabolism_Homo sapiens_hsa005910.90739770
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88402536
79mRNA surveillance pathway_Homo sapiens_hsa030150.87788718
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87275686
81Alcoholism_Homo sapiens_hsa050340.86584041
82Glutamatergic synapse_Homo sapiens_hsa047240.84303311
83Endometrial cancer_Homo sapiens_hsa052130.83686319
84Sphingolipid metabolism_Homo sapiens_hsa006000.82425284
85Hepatitis C_Homo sapiens_hsa051600.82241501
86Arachidonic acid metabolism_Homo sapiens_hsa005900.81031471
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79529357
88N-Glycan biosynthesis_Homo sapiens_hsa005100.78449130
89Prion diseases_Homo sapiens_hsa050200.78307674
90Insulin signaling pathway_Homo sapiens_hsa049100.78307593
91Hepatitis B_Homo sapiens_hsa051610.78147882
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76727078
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74566382
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72945916
95B cell receptor signaling pathway_Homo sapiens_hsa046620.72050713
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68977785
97Tuberculosis_Homo sapiens_hsa051520.68463299
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68092338
99Choline metabolism in cancer_Homo sapiens_hsa052310.67592586
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67439515
101Osteoclast differentiation_Homo sapiens_hsa043800.67402301
102Fatty acid metabolism_Homo sapiens_hsa012120.67337033
103TGF-beta signaling pathway_Homo sapiens_hsa043500.66795398
104Taste transduction_Homo sapiens_hsa047420.61467450
105Shigellosis_Homo sapiens_hsa051310.61245620
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60805491
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.60682832
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60566401
109RNA transport_Homo sapiens_hsa030130.60226305
110Thyroid cancer_Homo sapiens_hsa052160.60192989
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59250550
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59175480
113HTLV-I infection_Homo sapiens_hsa051660.58647525
114Prostate cancer_Homo sapiens_hsa052150.57982621
115Insulin resistance_Homo sapiens_hsa049310.55644840
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55604201
117Morphine addiction_Homo sapiens_hsa050320.55377566
118Viral carcinogenesis_Homo sapiens_hsa052030.55264539
119Gap junction_Homo sapiens_hsa045400.55161700
120Sulfur relay system_Homo sapiens_hsa041220.52556031
121TNF signaling pathway_Homo sapiens_hsa046680.51548454
122Tight junction_Homo sapiens_hsa045300.50970857
123Ras signaling pathway_Homo sapiens_hsa040140.50796151
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50745638
125Rheumatoid arthritis_Homo sapiens_hsa053230.49611320
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49126089
127Folate biosynthesis_Homo sapiens_hsa007900.48336219
128Pancreatic cancer_Homo sapiens_hsa052120.45900819
129Synaptic vesicle cycle_Homo sapiens_hsa047210.43619707
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.43589935
131Herpes simplex infection_Homo sapiens_hsa051680.43588112
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43572949
133Pyrimidine metabolism_Homo sapiens_hsa002400.43383130
134ErbB signaling pathway_Homo sapiens_hsa040120.43259774
135Vibrio cholerae infection_Homo sapiens_hsa051100.42817336
136Pertussis_Homo sapiens_hsa051330.41523739
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41438312
138Glioma_Homo sapiens_hsa052140.41100587
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39482788
140Oocyte meiosis_Homo sapiens_hsa041140.39385266
141MAPK signaling pathway_Homo sapiens_hsa040100.39265364
142Metabolic pathways_Homo sapiens_hsa011000.39200684
143Influenza A_Homo sapiens_hsa051640.38986488
144p53 signaling pathway_Homo sapiens_hsa041150.38928117
145Systemic lupus erythematosus_Homo sapiens_hsa053220.38904302
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36698421
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36468594
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35097833
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34775932
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34503231
151Vitamin B6 metabolism_Homo sapiens_hsa007500.33745424
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32773998
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30616128
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.29167334
155Acute myeloid leukemia_Homo sapiens_hsa052210.28755222
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27421290
157Phagosome_Homo sapiens_hsa041450.23949471
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22775675
159Amphetamine addiction_Homo sapiens_hsa050310.22742188
160Bladder cancer_Homo sapiens_hsa052190.21911301
161Epstein-Barr virus infection_Homo sapiens_hsa051690.21281334
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20467849
163Dopaminergic synapse_Homo sapiens_hsa047280.20340403
164Melanogenesis_Homo sapiens_hsa049160.19823010
165Adherens junction_Homo sapiens_hsa045200.19511493
166Mineral absorption_Homo sapiens_hsa049780.18871351
167Colorectal cancer_Homo sapiens_hsa052100.17081515
168VEGF signaling pathway_Homo sapiens_hsa043700.16720193
169Autoimmune thyroid disease_Homo sapiens_hsa053200.16528621

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