ZBTB45P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.77436399
2positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.23550006
3cytoskeletal anchoring at plasma membrane (GO:0007016)4.17160551
4synaptic vesicle docking involved in exocytosis (GO:0016081)3.63408653
5activation of Rac GTPase activity (GO:0032863)3.61838885
6glutamate secretion (GO:0014047)3.59620520
7mRNA cleavage (GO:0006379)3.52630342
8negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.49229559
9hemidesmosome assembly (GO:0031581)3.39072755
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.38241564
11cell-substrate adherens junction assembly (GO:0007045)3.37552847
12focal adhesion assembly (GO:0048041)3.37552847
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35724256
14TOR signaling (GO:0031929)3.23959589
15positive regulation of catecholamine secretion (GO:0033605)3.22168358
16negative regulation of response to reactive oxygen species (GO:1901032)3.21019675
17protein complex localization (GO:0031503)3.19789844
18adherens junction assembly (GO:0034333)3.19747483
19branching involved in salivary gland morphogenesis (GO:0060445)3.18186950
20protein retention in ER lumen (GO:0006621)3.08163318
21notochord development (GO:0030903)3.06358317
22regulation of hydrogen peroxide-induced cell death (GO:1903205)3.05633481
23regulation of autophagic vacuole assembly (GO:2000785)3.04601841
24nucleobase-containing small molecule interconversion (GO:0015949)2.98598781
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92122044
26activation of protein kinase B activity (GO:0032148)2.87325824
27apoptotic process involved in morphogenesis (GO:0060561)2.87154061
28cell-substrate junction assembly (GO:0007044)2.86864955
29receptor catabolic process (GO:0032801)2.86392429
30coenzyme catabolic process (GO:0009109)2.84744986
31regulation of oxidative stress-induced neuron death (GO:1903203)2.84701393
32Golgi transport vesicle coating (GO:0048200)2.84074034
33COPI coating of Golgi vesicle (GO:0048205)2.84074034
34thyroid gland development (GO:0030878)2.81748748
35establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.80653906
36regulation of oxidative phosphorylation (GO:0002082)2.78367096
37receptor recycling (GO:0001881)2.77720104
38epithelial cell-cell adhesion (GO:0090136)2.76404878
39negative regulation of cell size (GO:0045792)2.68878250
40regulation of translational fidelity (GO:0006450)2.68218968
41endothelial cell chemotaxis (GO:0035767)2.65737063
42regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62270628
43membrane tubulation (GO:0097320)2.61964414
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61830279
45establishment of apical/basal cell polarity (GO:0035089)2.61037347
46cell-cell junction maintenance (GO:0045217)2.60756020
47cellular response to lithium ion (GO:0071285)2.60092896
48regulation of keratinocyte differentiation (GO:0045616)2.58530740
49regulation of receptor binding (GO:1900120)2.58412700
50lung epithelium development (GO:0060428)2.57857448
51hippo signaling (GO:0035329)2.56473744
52ribosome assembly (GO:0042255)2.50457048
53regulation of cellular respiration (GO:0043457)2.49894680
54cGMP-mediated signaling (GO:0019934)2.49695082
55protein localization to cell surface (GO:0034394)2.49145346
56negative regulation of fatty acid transport (GO:2000192)2.47452279
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47107053
58rRNA transcription (GO:0009303)2.46664735
59heterochromatin organization (GO:0070828)2.45868251
60barbed-end actin filament capping (GO:0051016)2.45733109
61regulation of transforming growth factor beta2 production (GO:0032909)2.44649301
62morphogenesis of embryonic epithelium (GO:0016331)2.44368099
63regulation of phospholipase A2 activity (GO:0032429)2.42371753
64cellular protein complex localization (GO:0034629)2.42279980
65regulation of cardioblast differentiation (GO:0051890)2.41479233
66cellular component maintenance (GO:0043954)2.41173345
67establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40951430
68establishment or maintenance of bipolar cell polarity (GO:0061245)2.40951430
69negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.40878316
70proline biosynthetic process (GO:0006561)2.40560772
71embryonic skeletal joint morphogenesis (GO:0060272)2.39304038
72protein localization to endosome (GO:0036010)2.38891629
73negative regulation of stem cell proliferation (GO:2000647)2.38333246
74regulation of hippo signaling (GO:0035330)2.37131116
75atrioventricular valve morphogenesis (GO:0003181)2.36951762
76response to muscle activity (GO:0014850)2.35167572
77nucleoside diphosphate biosynthetic process (GO:0009133)2.34686517
78regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.33407571
79regulation of vacuole organization (GO:0044088)2.31504921
80positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.31324169
81cell volume homeostasis (GO:0006884)2.29812998
82regulation of cholesterol homeostasis (GO:2000188)2.28961783
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.28513173
84urea cycle (GO:0000050)2.25914844
85regulation of keratinocyte proliferation (GO:0010837)2.25021575
86response to food (GO:0032094)2.24927445
87motile cilium assembly (GO:0044458)2.24861420
88mitotic chromosome condensation (GO:0007076)2.24848473
89semaphorin-plexin signaling pathway (GO:0071526)2.24368721
90paraxial mesoderm development (GO:0048339)2.23783601
91positive regulation of epidermal cell differentiation (GO:0045606)2.21907341
92positive regulation of keratinocyte differentiation (GO:0045618)2.21904732
93regulation of apoptotic process involved in morphogenesis (GO:1902337)2.21482475
94homocysteine metabolic process (GO:0050667)2.21355730
95regulation of glucocorticoid metabolic process (GO:0031943)2.20301391
96negative regulation of striated muscle cell apoptotic process (GO:0010664)2.19740776
97sodium ion export (GO:0071436)2.19580684
98peptidyl-lysine dimethylation (GO:0018027)2.18445944
99keratinocyte proliferation (GO:0043616)2.17165415
100negative regulation of microtubule polymerization (GO:0031115)2.16393253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.30663821
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.20253168
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75983179
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.21069816
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.64515713
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.62600497
7RACK7_27058665_Chip-Seq_MCF-7_Human2.56424105
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48639191
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44734054
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44667670
11AR_21909140_ChIP-Seq_LNCAP_Human2.42670911
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40376558
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.21297885
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.21239690
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16148632
16LXR_22292898_ChIP-Seq_THP-1_Human2.08168330
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04956864
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03656602
19ATF3_27146783_Chip-Seq_COLON_Human1.98163522
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95435136
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.82410480
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.80657984
23KDM2B_26808549_Chip-Seq_K562_Human1.79377305
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.79263643
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.72529785
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68767230
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67753675
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67753675
29SMC4_20622854_ChIP-Seq_HELA_Human1.63977513
30E2F7_22180533_ChIP-Seq_HELA_Human1.63645321
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63167808
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.61488616
33CREB1_26743006_Chip-Seq_LNCaP_Human1.60535354
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55473093
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53539359
36CHD1_26751641_Chip-Seq_LNCaP_Human1.53377502
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51787697
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51064612
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.50701164
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50324677
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50215513
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47856258
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47229488
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.47023272
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45218469
46GATA6_25053715_ChIP-Seq_YYC3_Human1.42181684
47AHR_22903824_ChIP-Seq_MCF-7_Human1.41289595
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40685156
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39019048
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39007284
51TP53_22127205_ChIP-Seq_IMR90_Human1.36783866
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36447895
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36255031
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33709200
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33510600
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33190383
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32076135
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30998392
59CTCF_27219007_Chip-Seq_Bcells_Human1.30596974
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30427945
61KDM2B_26808549_Chip-Seq_DND41_Human1.30231301
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.29983424
63P68_20966046_ChIP-Seq_HELA_Human1.29597779
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.29453799
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29394472
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.26308936
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23705342
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23630667
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23580943
70CLOCK_20551151_ChIP-Seq_293T_Human1.22891072
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21321080
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19034396
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18960838
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18132774
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17546727
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15464739
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13107903
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08010993
79VDR_21846776_ChIP-Seq_THP-1_Human1.05641421
80ELF5_23300383_ChIP-Seq_T47D_Human1.04100089
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.04099197
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02570302
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02254545
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01877791
85DCP1A_22483619_ChIP-Seq_HELA_Human1.00395772
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99727464
87SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99604268
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99517406
89RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99083227
90EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99083227
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.98414746
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96883981
93GATA3_24758297_ChIP-Seq_MCF-7_Human0.96708794
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96288462
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95586828
96XRN2_22483619_ChIP-Seq_HELA_Human0.94831362
97SOX2_20726797_ChIP-Seq_SW620_Human0.94582937
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94538691
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.93975259
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.93911079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.58128466
2MP0000537_abnormal_urethra_morphology4.27728273
3MP0003315_abnormal_perineum_morphology3.44768493
4MP0001849_ear_inflammation2.66243642
5MP0005076_abnormal_cell_differentiation2.51385741
6MP0000678_abnormal_parathyroid_gland2.40409808
7MP0003705_abnormal_hypodermis_morpholog2.35493585
8MP0004233_abnormal_muscle_weight2.24366211
9MP0009780_abnormal_chondrocyte_physiolo2.17318121
10MP0004859_abnormal_synaptic_plasticity2.01930216
11MP0004264_abnormal_extraembryonic_tissu2.01761253
12MP0004272_abnormal_basement_membrane1.93267868
13MP0002796_impaired_skin_barrier1.91914349
14MP0005409_darkened_coat_color1.89396744
15MP0002249_abnormal_larynx_morphology1.82141502
16MP0004185_abnormal_adipocyte_glucose1.75130469
17MP0010678_abnormal_skin_adnexa1.73950221
18MP0005623_abnormal_meninges_morphology1.72582857
19MP0002877_abnormal_melanocyte_morpholog1.64570484
20MP0000762_abnormal_tongue_morphology1.63963652
21MP0000579_abnormal_nail_morphology1.61368150
22MP0003693_abnormal_embryo_hatching1.61165262
23MP0005451_abnormal_body_composition1.56861706
24MP0002160_abnormal_reproductive_system1.55341332
25MP0000566_synostosis1.50691223
26MP0003879_abnormal_hair_cell1.48494939
27MP0005501_abnormal_skin_physiology1.47104695
28MP0009840_abnormal_foam_cell1.46668198
29MP0003453_abnormal_keratinocyte_physiol1.39300188
30MP0000013_abnormal_adipose_tissue1.38707734
31MP0010030_abnormal_orbit_morphology1.38060254
32MP0000467_abnormal_esophagus_morphology1.37295374
33MP0000749_muscle_degeneration1.35912561
34MP0003123_paternal_imprinting1.35826457
35MP0010352_gastrointestinal_tract_polyps1.33399866
36MP0001664_abnormal_digestion1.28373532
37MP0004782_abnormal_surfactant_physiolog1.23703537
38MP0005670_abnormal_white_adipose1.23122414
39MP0002098_abnormal_vibrissa_morphology1.22382763
40MP0000462_abnormal_digestive_system1.20731758
41MP0001348_abnormal_lacrimal_gland1.20630537
42MP0003566_abnormal_cell_adhesion1.19520693
43MP0000733_abnormal_muscle_development1.18600564
44MP0001661_extended_life_span1.18291437
45MP0003806_abnormal_nucleotide_metabolis1.16539140
46MP0000003_abnormal_adipose_tissue1.16306599
47MP0005083_abnormal_biliary_tract1.15701329
48MP0008004_abnormal_stomach_pH1.14237331
49MP0000516_abnormal_urinary_system1.13642415
50MP0005367_renal/urinary_system_phenotyp1.13642415
51MP0000534_abnormal_ureter_morphology1.10453751
52MP0009053_abnormal_anal_canal1.06441352
53MP0003385_abnormal_body_wall1.06311448
54MP0000627_abnormal_mammary_gland1.05421017
55MP0000383_abnormal_hair_follicle1.04649182
56MP0004858_abnormal_nervous_system1.01712347
57MP0004270_analgesia0.98469610
58MP0005187_abnormal_penis_morphology0.94389037
59MP0001188_hyperpigmentation0.93738032
60MP0009250_abnormal_appendicular_skeleto0.92585357
61MP0009697_abnormal_copulation0.91546229
62MP0002089_abnormal_postnatal_growth/wei0.91164867
63MP0002108_abnormal_muscle_morphology0.89340055
64MP0004957_abnormal_blastocyst_morpholog0.89210614
65MP0001340_abnormal_eyelid_morphology0.88591651
66MP0010771_integument_phenotype0.87801447
67MP0004087_abnormal_muscle_fiber0.87190106
68MP0002086_abnormal_extraembryonic_tissu0.86634259
69MP0001216_abnormal_epidermal_layer0.86416381
70MP0003635_abnormal_synaptic_transmissio0.84981627
71MP0002060_abnormal_skin_morphology0.83692154
72MP0003942_abnormal_urinary_system0.82862956
73MP0000747_muscle_weakness0.82706636
74MP0003868_abnormal_feces_composition0.82255919
75MP0003283_abnormal_digestive_organ0.81876535
76MP0001730_embryonic_growth_arrest0.81803371
77MP0000538_abnormal_urinary_bladder0.81491676
78MP0002269_muscular_atrophy0.80330391
79MP0005330_cardiomyopathy0.79766561
80MP0004084_abnormal_cardiac_muscle0.79715649
81MP0005360_urolithiasis0.79308579
82MP0010368_abnormal_lymphatic_system0.77297842
83MP0000759_abnormal_skeletal_muscle0.76886201
84MP0000681_abnormal_thyroid_gland0.76509297
85MP0005646_abnormal_pituitary_gland0.74515847
86MP0001346_abnormal_lacrimal_gland0.74325140
87MP0005423_abnormal_somatic_nervous0.73676063
88MP0001485_abnormal_pinna_reflex0.72881405
89MP0002233_abnormal_nose_morphology0.72534218
90MP0006138_congestive_heart_failure0.72459525
91MP0005666_abnormal_adipose_tissue0.70602221
92MP0004197_abnormal_fetal_growth/weight/0.70401032
93MP0003984_embryonic_growth_retardation0.70034988
94MP0000049_abnormal_middle_ear0.69734035
95MP0003935_abnormal_craniofacial_develop0.68971313
96MP0001672_abnormal_embryogenesis/_devel0.68914046
97MP0005380_embryogenesis_phenotype0.68914046
98MP0002080_prenatal_lethality0.68604221
99MP0001502_abnormal_circadian_rhythm0.68314270
100MP0000751_myopathy0.67759338

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.07070493
2Hyperacusis (HP:0010780)3.66112813
3Abnormality of the columella (HP:0009929)3.48632989
4Sensory axonal neuropathy (HP:0003390)3.46910074
5Resting tremor (HP:0002322)3.22502932
6Ulnar bowing (HP:0003031)2.95490104
7Broad face (HP:0000283)2.87939804
8Aplasia cutis congenita (HP:0001057)2.80516641
9Pili torti (HP:0003777)2.69761574
10Dysmetric saccades (HP:0000641)2.64142354
11High anterior hairline (HP:0009890)2.63285763
12Abnormality of the distal phalanges of the toes (HP:0010182)2.58413092
13Hyporeflexia of lower limbs (HP:0002600)2.54771988
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.50219806
15Deviation of the thumb (HP:0009603)2.49830891
16Insomnia (HP:0100785)2.49507691
17Short nail (HP:0001799)2.45968881
18Reduced antithrombin III activity (HP:0001976)2.35776970
19Urinary urgency (HP:0000012)2.34937753
20Clumsiness (HP:0002312)2.34803164
21Aplasia involving bones of the upper limbs (HP:0009823)2.33105187
22Aplasia of the phalanges of the hand (HP:0009802)2.33105187
23Aplasia involving bones of the extremities (HP:0009825)2.33105187
24Self-mutilation (HP:0000742)2.30393160
25Proximal placement of thumb (HP:0009623)2.26198888
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.25630546
27Distal lower limb amyotrophy (HP:0008944)2.24731351
28Abnormality of the nasal septum (HP:0000419)2.19960374
29Spinal rigidity (HP:0003306)2.15132879
30Pterygium (HP:0001059)2.15097055
31Ankyloglossia (HP:0010296)2.14279588
32Popliteal pterygium (HP:0009756)2.13732605
33Asymmetry of the thorax (HP:0001555)2.12936221
34Abnormality of the intrinsic pathway (HP:0010989)2.11691021
35Scapular winging (HP:0003691)2.08572789
36Spinal cord compression (HP:0002176)2.07529485
37Septate vagina (HP:0001153)2.07104845
38Nasolacrimal duct obstruction (HP:0000579)2.06882064
39Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.06347587
40Reduced subcutaneous adipose tissue (HP:0003758)2.02377655
41Overriding aorta (HP:0002623)1.99281457
42Progressive muscle weakness (HP:0003323)1.98685760
43Exercise-induced myalgia (HP:0003738)1.98192140
44Elfin facies (HP:0004428)1.97501790
45Abnormality of the shoulder girdle musculature (HP:0001435)1.96884340
46Bronchomalacia (HP:0002780)1.93138481
47Abnormal hair laboratory examination (HP:0003328)1.90576933
48Abnormality of the frontal sinuses (HP:0002687)1.90058819
49Truncal ataxia (HP:0002078)1.88555067
50Upper limb amyotrophy (HP:0009129)1.88060377
51Distal upper limb amyotrophy (HP:0007149)1.88060377
52Ureteral duplication (HP:0000073)1.87673820
53Lip pit (HP:0100267)1.87099549
54Long palpebral fissure (HP:0000637)1.86292732
55Renal duplication (HP:0000075)1.86240295
56Achilles tendon contracture (HP:0001771)1.84699617
57Thoracic kyphosis (HP:0002942)1.84287474
58Elbow flexion contracture (HP:0002987)1.83046418
59Hypoplasia of the uterus (HP:0000013)1.82924313
60Flat acetabular roof (HP:0003180)1.82866440
61Advanced eruption of teeth (HP:0006288)1.81551194
62Ragged-red muscle fibers (HP:0003200)1.80192314
63Difficulty climbing stairs (HP:0003551)1.79068418
64Bulbar palsy (HP:0001283)1.77922581
65Facial hemangioma (HP:0000329)1.77671826
66Diaphragmatic weakness (HP:0009113)1.76204847
67Ankle clonus (HP:0011448)1.76168544
68Depression (HP:0000716)1.75451636
69Trismus (HP:0000211)1.74381077
70Axonal loss (HP:0003447)1.74190713
71Abnormality of the thoracic spine (HP:0100711)1.74034156
72Abnormality of the distal phalanx of the thumb (HP:0009617)1.73152010
73Abnormality of the gastric mucosa (HP:0004295)1.71897585
74Broad nasal tip (HP:0000455)1.71289590
75Abnormality of oral frenula (HP:0000190)1.71212706
76Short humerus (HP:0005792)1.70567793
77Milia (HP:0001056)1.70566003
78Germ cell neoplasia (HP:0100728)1.70442094
79Lower limb amyotrophy (HP:0007210)1.69453346
80Multiple lipomas (HP:0001012)1.67147437
81Squamous cell carcinoma (HP:0002860)1.66986612
82Abnormality of the lacrimal duct (HP:0011481)1.66389871
83Cerebellar dysplasia (HP:0007033)1.64742924
84Bifid scrotum (HP:0000048)1.62545786
85Aplasia/hypoplasia of the humerus (HP:0006507)1.61442056
86Short 1st metacarpal (HP:0010034)1.61422483
87Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61422483
88Testicular atrophy (HP:0000029)1.60835293
89Hypoplasia of dental enamel (HP:0006297)1.60352395
90Absent radius (HP:0003974)1.59413184
91Abnormality of the Achilles tendon (HP:0005109)1.59108632
92Abnormality of the 1st metacarpal (HP:0010009)1.58066773
93Acanthosis nigricans (HP:0000956)1.56291934
94Ventricular fibrillation (HP:0001663)1.56276925
95Focal segmental glomerulosclerosis (HP:0000097)1.55174129
96Micronodular cirrhosis (HP:0001413)1.54617069
97Generalized amyotrophy (HP:0003700)1.54396371
98Bowed forearm bones (HP:0003956)1.53251981
99Bowing of the arm (HP:0006488)1.53251981
100Open mouth (HP:0000194)1.51945480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.39951480
2EPHA25.27321924
3PINK13.58583165
4TRIB33.13577018
5LATS23.06734913
6ICK2.91333999
7SIK12.83103592
8NME22.79041293
9EEF2K2.73143604
10LATS12.67712035
11MET2.39692415
12IRAK32.12838784
13MAP3K92.06596413
14LMTK21.82098551
15SMG11.75032632
16ARAF1.57440953
17PKN21.52892081
18CDK121.50598585
19RIPK11.48912076
20NEK21.40172699
21EPHA41.34329509
22PIM21.34132772
23PRKD31.33627591
24MARK31.30008645
25STK381.28597627
26MTOR1.23052090
27PRKG21.16728027
28PTK21.11356806
29STK38L1.07618948
30MYLK1.05527229
31NEK61.04898927
32PDK21.01908308
33IRAK21.01454264
34PBK1.01373954
35RPS6KB21.00209165
36STK391.00076411
37PAK40.97083855
38MAP2K70.96974782
39SCYL20.96574967
40CDK80.91395054
41CAMK1D0.88487446
42CSNK1A1L0.85897533
43MAP3K10.84202874
44PDPK10.82369546
45MUSK0.79791168
46MAP3K100.76497330
47AKT20.75075608
48PHKG10.74729270
49PHKG20.74729270
50MELK0.73541648
51MAPKAPK30.71281905
52RPS6KB10.67632991
53RPS6KA40.64286419
54NTRK10.64049488
55CAMK2B0.61794698
56PAK20.61588967
57ILK0.59447964
58TAOK10.56313278
59NME10.55645120
60PRKCI0.53953434
61DAPK10.53869712
62TTN0.51936946
63CDK90.51351982
64AURKA0.50381105
65PTK60.49902055
66RAF10.49734041
67BRAF0.49059996
68CSNK1G30.47902245
69AURKB0.47291226
70MAP2K10.46843713
71MAP3K30.45917193
72SGK4940.45846473
73SGK2230.45846473
74PDGFRA0.45573404
75BRSK10.44888664
76CAMK1G0.44453875
77MAP3K130.43826419
78CCNB10.43721190
79MARK20.42807592
80MAPK110.42576725
81ERBB40.41694844
82CAMK2G0.41517275
83MAP3K20.40483296
84DAPK30.38958263
85AKT30.37254594
86MAPK120.36419505
87TESK10.36146438
88MINK10.35431601
89OBSCN0.35155370
90PAK10.34565429
91TLK10.33564765
92RPS6KA20.32355921
93FER0.31546303
94PDK10.31286807
95CDK70.31116531
96SGK30.30995777
97RET0.30179994
98MAP3K80.28968481
99CDK30.27394594
100CDK50.25603705

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002202.09306968
2Vitamin B6 metabolism_Homo sapiens_hsa007501.94981395
3Thyroid cancer_Homo sapiens_hsa052161.75071160
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72317289
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69221748
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57379711
7Gap junction_Homo sapiens_hsa045401.50861153
8Fructose and mannose metabolism_Homo sapiens_hsa000511.47909964
9Hippo signaling pathway_Homo sapiens_hsa043901.46622475
10Fatty acid biosynthesis_Homo sapiens_hsa000611.45174234
11Long-term potentiation_Homo sapiens_hsa047201.41996115
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40247795
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.36399998
14Gastric acid secretion_Homo sapiens_hsa049711.33562096
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30641467
16Pentose phosphate pathway_Homo sapiens_hsa000301.29618540
17Endometrial cancer_Homo sapiens_hsa052131.27033305
18Tight junction_Homo sapiens_hsa045301.25549684
19Hedgehog signaling pathway_Homo sapiens_hsa043401.25492223
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24984170
21Sulfur relay system_Homo sapiens_hsa041221.24373295
22Biosynthesis of amino acids_Homo sapiens_hsa012301.22422146
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20390976
24AMPK signaling pathway_Homo sapiens_hsa041521.20346879
25Glucagon signaling pathway_Homo sapiens_hsa049221.18954181
26Pancreatic secretion_Homo sapiens_hsa049721.18890720
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17821321
28Phenylalanine metabolism_Homo sapiens_hsa003601.16024233
29Olfactory transduction_Homo sapiens_hsa047401.13718691
30Adherens junction_Homo sapiens_hsa045201.12619236
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04036046
32Melanogenesis_Homo sapiens_hsa049161.01611926
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01457800
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00177019
35Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98695956
36mTOR signaling pathway_Homo sapiens_hsa041500.97240801
37TGF-beta signaling pathway_Homo sapiens_hsa043500.97137218
38Glioma_Homo sapiens_hsa052140.96780923
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96648976
40Bile secretion_Homo sapiens_hsa049760.96479411
41ErbB signaling pathway_Homo sapiens_hsa040120.96478472
42Estrogen signaling pathway_Homo sapiens_hsa049150.95303301
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94660449
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94465274
45Insulin signaling pathway_Homo sapiens_hsa049100.94406188
46Synaptic vesicle cycle_Homo sapiens_hsa047210.93840827
47Pyruvate metabolism_Homo sapiens_hsa006200.93528598
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92855574
49Salivary secretion_Homo sapiens_hsa049700.91404110
50Circadian entrainment_Homo sapiens_hsa047130.90704257
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90275880
52Axon guidance_Homo sapiens_hsa043600.89013012
53Wnt signaling pathway_Homo sapiens_hsa043100.85378968
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84567455
55Bladder cancer_Homo sapiens_hsa052190.84324119
56Galactose metabolism_Homo sapiens_hsa000520.82542879
57Focal adhesion_Homo sapiens_hsa045100.81685564
58Oxytocin signaling pathway_Homo sapiens_hsa049210.81289352
59Renin secretion_Homo sapiens_hsa049240.80680289
60Alcoholism_Homo sapiens_hsa050340.79039175
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78904525
62Oocyte meiosis_Homo sapiens_hsa041140.78437397
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77790756
64ECM-receptor interaction_Homo sapiens_hsa045120.75235132
65Small cell lung cancer_Homo sapiens_hsa052220.74532876
66Circadian rhythm_Homo sapiens_hsa047100.73440372
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.72603942
68Amphetamine addiction_Homo sapiens_hsa050310.71865956
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70023567
70Thyroid hormone synthesis_Homo sapiens_hsa049180.68967063
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68806625
72Basal cell carcinoma_Homo sapiens_hsa052170.68306652
73Proteoglycans in cancer_Homo sapiens_hsa052050.68047040
74GnRH signaling pathway_Homo sapiens_hsa049120.65696751
75Arginine and proline metabolism_Homo sapiens_hsa003300.64606008
76Dilated cardiomyopathy_Homo sapiens_hsa054140.63836720
77N-Glycan biosynthesis_Homo sapiens_hsa005100.62697558
78Carbon metabolism_Homo sapiens_hsa012000.61818831
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61223134
80DNA replication_Homo sapiens_hsa030300.60226029
81mRNA surveillance pathway_Homo sapiens_hsa030150.58656256
82Calcium signaling pathway_Homo sapiens_hsa040200.57507480
83Protein digestion and absorption_Homo sapiens_hsa049740.57205628
84Inositol phosphate metabolism_Homo sapiens_hsa005620.56284036
85Chronic myeloid leukemia_Homo sapiens_hsa052200.55247879
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55149499
87Glutamatergic synapse_Homo sapiens_hsa047240.54577624
88Nitrogen metabolism_Homo sapiens_hsa009100.54030602
89Prostate cancer_Homo sapiens_hsa052150.53761125
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53338130
91Insulin secretion_Homo sapiens_hsa049110.53149216
92Cholinergic synapse_Homo sapiens_hsa047250.51206991
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50981730
94Nicotine addiction_Homo sapiens_hsa050330.50871889
95Dopaminergic synapse_Homo sapiens_hsa047280.50767477
96Non-small cell lung cancer_Homo sapiens_hsa052230.50578701
97Mineral absorption_Homo sapiens_hsa049780.50374722
98Apoptosis_Homo sapiens_hsa042100.49239648
99Folate biosynthesis_Homo sapiens_hsa007900.46698823
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46456301

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