ZBTB45P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.92912548
2hemidesmosome assembly (GO:0031581)4.83412370
3atrioventricular valve morphogenesis (GO:0003181)4.45262412
4activation of Rac GTPase activity (GO:0032863)4.43281741
5epithelial cell-cell adhesion (GO:0090136)3.99330080
6bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98925110
7Golgi transport vesicle coating (GO:0048200)3.75760716
8COPI coating of Golgi vesicle (GO:0048205)3.75760716
9cell-substrate junction assembly (GO:0007044)3.58398018
10regulation of glucose import in response to insulin stimulus (GO:2001273)3.55468579
11apoptotic process involved in morphogenesis (GO:0060561)3.50562005
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.48452599
13cell-substrate adherens junction assembly (GO:0007045)3.41455539
14focal adhesion assembly (GO:0048041)3.41455539
15protein retention in ER lumen (GO:0006621)3.39453811
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37152553
17adherens junction assembly (GO:0034333)3.29676372
18positive regulation of osteoblast proliferation (GO:0033690)3.27501736
19urea cycle (GO:0000050)3.25687433
20negative regulation of fatty acid transport (GO:2000192)3.25663677
21regulation of fatty acid beta-oxidation (GO:0031998)3.23320921
22regulation of translational fidelity (GO:0006450)3.12937247
23negative regulation of cell size (GO:0045792)3.10980872
24proline biosynthetic process (GO:0006561)3.07891037
25branching involved in mammary gland duct morphogenesis (GO:0060444)3.03392771
26homocysteine metabolic process (GO:0050667)3.03072335
27positive regulation of fatty acid beta-oxidation (GO:0032000)3.02876221
28protein localization to endosome (GO:0036010)3.01418615
29positive regulation of Cdc42 GTPase activity (GO:0043089)2.99172550
30positive regulation of epidermal cell differentiation (GO:0045606)2.94175327
31urea metabolic process (GO:0019627)2.94006472
32endothelial cell chemotaxis (GO:0035767)2.91821763
33mitotic chromosome condensation (GO:0007076)2.91706601
34branching involved in salivary gland morphogenesis (GO:0060445)2.87322874
35regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.85444928
36regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85221775
37skin morphogenesis (GO:0043589)2.82287762
38receptor catabolic process (GO:0032801)2.81371785
39regulation of cell proliferation involved in kidney development (GO:1901722)2.81085548
40cell adhesion mediated by integrin (GO:0033627)2.80491373
41response to food (GO:0032094)2.80474562
42myelin maintenance (GO:0043217)2.78550809
43gap junction assembly (GO:0016264)2.77733640
44maternal placenta development (GO:0001893)2.77413997
45nucleobase-containing small molecule interconversion (GO:0015949)2.77174516
46renal filtration (GO:0097205)2.76631773
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76323391
48regulation of hippo signaling (GO:0035330)2.73124667
49protein complex localization (GO:0031503)2.72896429
50basement membrane organization (GO:0071711)2.70620054
51citrulline biosynthetic process (GO:0019240)2.70269936
52positive regulation of keratinocyte differentiation (GO:0045618)2.69730874
53regulation of water loss via skin (GO:0033561)2.69586048
54regulation of cholesterol homeostasis (GO:2000188)2.69085089
55cellular protein complex localization (GO:0034629)2.68882020
56endothelial cell morphogenesis (GO:0001886)2.68610914
57establishment of apical/basal cell polarity (GO:0035089)2.67587961
58heterochromatin organization (GO:0070828)2.66593737
59hippo signaling (GO:0035329)2.64144534
60positive regulation of pseudopodium assembly (GO:0031274)2.63330581
61morphogenesis of embryonic epithelium (GO:0016331)2.61438009
62protein localization to microtubule (GO:0035372)2.55617404
63negative regulation of viral release from host cell (GO:1902187)2.55364388
64positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.54457881
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54019733
66glucose catabolic process (GO:0006007)2.53270275
67barbed-end actin filament capping (GO:0051016)2.52594782
68regulation of translational termination (GO:0006449)2.49504562
69notochord development (GO:0030903)2.48010392
70regulation of early endosome to late endosome transport (GO:2000641)2.46927706
71negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46503591
72regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46189910
73citrulline metabolic process (GO:0000052)2.46135300
74tight junction assembly (GO:0070830)2.44742301
75nitrogen cycle metabolic process (GO:0071941)2.44251791
76regulation of keratinocyte differentiation (GO:0045616)2.42917084
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41780711
78positive regulation of fatty acid oxidation (GO:0046321)2.41032156
79receptor recycling (GO:0001881)2.39935065
80establishment or maintenance of bipolar cell polarity (GO:0061245)2.39922894
81establishment or maintenance of apical/basal cell polarity (GO:0035088)2.39922894
82negative regulation of chondrocyte differentiation (GO:0032331)2.39259758
83regulation of cholesterol biosynthetic process (GO:0045540)2.38894904
84keratinocyte proliferation (GO:0043616)2.38346733
85DNA unwinding involved in DNA replication (GO:0006268)2.37172468
86ribosome assembly (GO:0042255)2.37137846
87negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.36957745
88positive regulation of protein localization to plasma membrane (GO:1903078)2.36878164
89cell-cell junction maintenance (GO:0045217)2.36656433
90nuclear pore complex assembly (GO:0051292)2.35939130
91regulation of transforming growth factor beta2 production (GO:0032909)2.35929562
92glucose 6-phosphate metabolic process (GO:0051156)2.35624470
93cellular response to hepatocyte growth factor stimulus (GO:0035729)2.34092729
94response to hepatocyte growth factor (GO:0035728)2.34092729
95muscle cell migration (GO:0014812)2.33948994
96GDP-mannose metabolic process (GO:0019673)2.33829684
97bone remodeling (GO:0046849)2.33754919
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33321254
99actin filament bundle assembly (GO:0051017)2.33179409
100actin filament bundle organization (GO:0061572)2.33179409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.22775804
2ZNF263_19887448_ChIP-Seq_K562_Human3.79043086
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95604330
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62527325
5RACK7_27058665_Chip-Seq_MCF-7_Human2.59751108
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.53556218
7E2F7_22180533_ChIP-Seq_HELA_Human2.33463197
8KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.32999972
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30368609
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28192970
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26868215
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.26013549
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.16223563
14LXR_22292898_ChIP-Seq_THP-1_Human2.11475580
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07634927
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06287107
17AR_21909140_ChIP-Seq_LNCAP_Human2.00563108
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.00455632
19ATF3_27146783_Chip-Seq_COLON_Human1.97651843
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97181627
21CLOCK_20551151_ChIP-Seq_293T_Human1.89446260
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.88326703
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77516490
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72498683
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72498683
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.70491989
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70117414
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68929729
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67918270
30VDR_21846776_ChIP-Seq_THP-1_Human1.67708183
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66896531
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66766763
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.65991491
34MYC_22102868_ChIP-Seq_BL_Human1.63776761
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60587145
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.59318943
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58806688
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57459746
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.57418959
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57283566
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56044758
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55613550
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.51855090
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51764459
45GATA6_25053715_ChIP-Seq_YYC3_Human1.49821142
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47797782
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47082348
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.44089689
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41898725
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41694516
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41255508
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40948114
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40809423
54TP53_22127205_ChIP-Seq_IMR90_Human1.39886048
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39299324
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37224813
57KDM2B_26808549_Chip-Seq_K562_Human1.36987042
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34462731
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.32083034
60CREB1_26743006_Chip-Seq_LNCaP_Human1.31766117
61CHD1_26751641_Chip-Seq_LNCaP_Human1.29449756
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28399430
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27519806
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23369354
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23357811
66SMC4_20622854_ChIP-Seq_HELA_Human1.23178607
67KDM2B_26808549_Chip-Seq_DND41_Human1.21833772
68TCF7_22412390_ChIP-Seq_EML_Mouse1.21825883
69P68_20966046_ChIP-Seq_HELA_Human1.21335736
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20518797
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16960256
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16704231
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15436154
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14393507
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14232522
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13909189
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13324484
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.12698484
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10503840
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10313347
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10067662
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09992679
83XRN2_22483619_ChIP-Seq_HELA_Human1.09278257
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.09089067
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08504490
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07230441
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.05606970
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04178270
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03697226
90SOX2_20726797_ChIP-Seq_SW620_Human1.03006609
91KLF5_25053715_ChIP-Seq_YYC3_Human1.02520517
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01195998
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00328365
94DCP1A_22483619_ChIP-Seq_HELA_Human1.00298273
95MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97166205
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94905667
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94313620
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93728046
99ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93061685
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92515366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.71814063
2MP0003705_abnormal_hypodermis_morpholog3.60948552
3MP0000537_abnormal_urethra_morphology3.28779357
4MP0000678_abnormal_parathyroid_gland3.12675240
5MP0005076_abnormal_cell_differentiation2.66319964
6MP0002796_impaired_skin_barrier2.60373102
7MP0002877_abnormal_melanocyte_morpholog2.46307809
8MP0003566_abnormal_cell_adhesion2.46006728
9MP0010352_gastrointestinal_tract_polyps2.40396226
10MP0001849_ear_inflammation2.16778036
11MP0005451_abnormal_body_composition2.14701268
12MP0005501_abnormal_skin_physiology2.10575979
13MP0003453_abnormal_keratinocyte_physiol2.04332654
14MP0004185_abnormal_adipocyte_glucose1.94790041
15MP0004272_abnormal_basement_membrane1.93048937
16MP0005083_abnormal_biliary_tract1.89964605
17MP0005409_darkened_coat_color1.88173740
18MP0004264_abnormal_extraembryonic_tissu1.87145480
19MP0000566_synostosis1.83896415
20MP0000762_abnormal_tongue_morphology1.76520707
21MP0004233_abnormal_muscle_weight1.76262966
22MP0003315_abnormal_perineum_morphology1.65021997
23MP0002060_abnormal_skin_morphology1.62246521
24MP0004782_abnormal_surfactant_physiolog1.59784739
25MP0005257_abnormal_intraocular_pressure1.59360400
26MP0009840_abnormal_foam_cell1.58662638
27MP0000733_abnormal_muscle_development1.57854137
28MP0010678_abnormal_skin_adnexa1.56758001
29MP0010030_abnormal_orbit_morphology1.55466770
30MP0003693_abnormal_embryo_hatching1.55410747
31MP0000467_abnormal_esophagus_morphology1.55195678
32MP0000579_abnormal_nail_morphology1.52369185
33MP0000003_abnormal_adipose_tissue1.45985004
34MP0001216_abnormal_epidermal_layer1.44684481
35MP0005023_abnormal_wound_healing1.44513113
36MP0001348_abnormal_lacrimal_gland1.42155922
37MP0002249_abnormal_larynx_morphology1.41154799
38MP0005360_urolithiasis1.37708447
39MP0002089_abnormal_postnatal_growth/wei1.34058916
40MP0005623_abnormal_meninges_morphology1.33417083
41MP0009780_abnormal_chondrocyte_physiolo1.30950189
42MP0002098_abnormal_vibrissa_morphology1.29744732
43MP0000751_myopathy1.27535243
44MP0009053_abnormal_anal_canal1.27070315
45MP0004858_abnormal_nervous_system1.23503458
46MP0004957_abnormal_blastocyst_morpholog1.21865453
47MP0005666_abnormal_adipose_tissue1.19120164
48MP0003091_abnormal_cell_migration1.18120276
49MP0005375_adipose_tissue_phenotype1.15465791
50MP0000013_abnormal_adipose_tissue1.12546712
51MP0010771_integument_phenotype1.11759887
52MP0005670_abnormal_white_adipose1.08012569
53MP0001730_embryonic_growth_arrest1.05034785
54MP0002896_abnormal_bone_mineralization1.03495992
55MP0001664_abnormal_digestion1.00287703
56MP0005275_abnormal_skin_tensile0.98028158
57MP0002086_abnormal_extraembryonic_tissu0.97601055
58MP0000462_abnormal_digestive_system0.96810238
59MP0003806_abnormal_nucleotide_metabolis0.96805822
60MP0009250_abnormal_appendicular_skeleto0.96171493
61MP0001661_extended_life_span0.95032011
62MP0005330_cardiomyopathy0.94277312
63MP0000627_abnormal_mammary_gland0.94211075
64MP0002108_abnormal_muscle_morphology0.92786769
65MP0006138_congestive_heart_failure0.92529160
66MP0008438_abnormal_cutaneous_collagen0.92331974
67MP0000490_abnormal_crypts_of0.92131659
68MP0000377_abnormal_hair_follicle0.91715736
69MP0000477_abnormal_intestine_morphology0.91562295
70MP0003111_abnormal_nucleus_morphology0.89864000
71MP0000747_muscle_weakness0.89767788
72MP0003191_abnormal_cellular_cholesterol0.86502343
73MP0004087_abnormal_muscle_fiber0.84628657
74MP0002080_prenatal_lethality0.83608618
75MP0000534_abnormal_ureter_morphology0.82206232
76MP0003077_abnormal_cell_cycle0.81949789
77MP0009931_abnormal_skin_appearance0.81209692
78MP0010368_abnormal_lymphatic_system0.80692728
79MP0004197_abnormal_fetal_growth/weight/0.79644593
80MP0000383_abnormal_hair_follicle0.79456919
81MP0003984_embryonic_growth_retardation0.78543570
82MP0003950_abnormal_plasma_membrane0.77041993
83MP0000350_abnormal_cell_proliferation0.76920850
84MP0003941_abnormal_skin_development0.76541582
85MP0005367_renal/urinary_system_phenotyp0.75878631
86MP0000516_abnormal_urinary_system0.75878631
87MP0003115_abnormal_respiratory_system0.74794548
88MP0002111_abnormal_tail_morphology0.74243408
89MP0005380_embryogenesis_phenotype0.73927316
90MP0001672_abnormal_embryogenesis/_devel0.73927316
91MP0002088_abnormal_embryonic_growth/wei0.73753301
92MP0010094_abnormal_chromosome_stability0.72930488
93MP0010630_abnormal_cardiac_muscle0.72741100
94MP0005503_abnormal_tendon_morphology0.72663317
95MP0005058_abnormal_lysosome_morphology0.72486580
96MP0000759_abnormal_skeletal_muscle0.72414760
97MP0005621_abnormal_cell_physiology0.72046327
98MP0000750_abnormal_muscle_regeneration0.71702091
99MP0002970_abnormal_white_adipose0.71346674
100MP0000858_altered_metastatic_potential0.70855418

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.91542373
2Hyperacusis (HP:0010780)3.72794480
3Broad face (HP:0000283)3.53940652
4Short nail (HP:0001799)3.30536822
5Abnormality of the distal phalanges of the toes (HP:0010182)3.17207501
6Distal lower limb amyotrophy (HP:0008944)3.13187710
7Deviation of the thumb (HP:0009603)2.94563434
8Ulnar bowing (HP:0003031)2.90326304
9Trismus (HP:0000211)2.84121124
10Pili torti (HP:0003777)2.82035587
11Spinal cord compression (HP:0002176)2.77521078
12Premature rupture of membranes (HP:0001788)2.76027107
13Fragile skin (HP:0001030)2.71841770
14Flat acetabular roof (HP:0003180)2.70115123
15Achilles tendon contracture (HP:0001771)2.66962786
16Proximal placement of thumb (HP:0009623)2.64598624
17Increased connective tissue (HP:0009025)2.63439695
18Aplasia cutis congenita (HP:0001057)2.61166533
19Focal segmental glomerulosclerosis (HP:0000097)2.54548650
20Abnormality of the distal phalanx of the thumb (HP:0009617)2.51550227
21Milia (HP:0001056)2.50891096
22Pterygium (HP:0001059)2.44142371
23Protrusio acetabuli (HP:0003179)2.40461396
24Nasolacrimal duct obstruction (HP:0000579)2.38566762
25Abnormality of the Achilles tendon (HP:0005109)2.33915590
26Lip pit (HP:0100267)2.33416171
27Elbow flexion contracture (HP:0002987)2.30015169
28Atrophic scars (HP:0001075)2.28399002
29Selective tooth agenesis (HP:0001592)2.28153698
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.27470875
31Osteolytic defects of the hand bones (HP:0009699)2.27470875
32Thin bony cortex (HP:0002753)2.25244219
33Ankyloglossia (HP:0010296)2.24102397
34Mildly elevated creatine phosphokinase (HP:0008180)2.24073743
35Advanced eruption of teeth (HP:0006288)2.22686072
36Progressive muscle weakness (HP:0003323)2.21621798
37Spinal rigidity (HP:0003306)2.20143943
38Distal lower limb muscle weakness (HP:0009053)2.15076336
39Asymmetry of the thorax (HP:0001555)2.13847557
40Difficulty climbing stairs (HP:0003551)2.10897308
41Ridged nail (HP:0001807)2.10797632
42Abnormality of the nasal septum (HP:0000419)2.09232007
43Abnormal hair laboratory examination (HP:0003328)2.08664531
44Vascular calcification (HP:0004934)2.08424731
45Hyperparathyroidism (HP:0000843)2.08159563
46Insomnia (HP:0100785)2.07044179
47Axonal loss (HP:0003447)2.05447467
48Shallow orbits (HP:0000586)2.04697239
49Hyperphosphatemia (HP:0002905)2.03893830
50Abnormality of oral frenula (HP:0000190)2.03546098
51Abdominal distention (HP:0003270)2.02747220
52Vertebral compression fractures (HP:0002953)2.01409798
53Dysmetric saccades (HP:0000641)2.00154063
54Hemorrhage of the eye (HP:0011885)2.00121284
55Resting tremor (HP:0002322)1.98983428
56Glomerulosclerosis (HP:0000096)1.97621714
57Reduced subcutaneous adipose tissue (HP:0003758)1.97209244
58Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97061084
59Septate vagina (HP:0001153)1.96535188
60Ragged-red muscle fibers (HP:0003200)1.95866460
61Centrally nucleated skeletal muscle fibers (HP:0003687)1.95766020
62Upper limb amyotrophy (HP:0009129)1.95199623
63Distal upper limb amyotrophy (HP:0007149)1.95199623
64Bowing of the arm (HP:0006488)1.94618367
65Bowed forearm bones (HP:0003956)1.94618367
66Elfin facies (HP:0004428)1.92662578
67Lower limb amyotrophy (HP:0007210)1.92421788
68Cardiovascular calcification (HP:0011915)1.91362759
69Abnormality of the gastric mucosa (HP:0004295)1.90740980
70Nail dystrophy (HP:0008404)1.90041863
71Abnormal ossification of hand bones (HP:0005921)1.89709677
72Acanthosis nigricans (HP:0000956)1.89516192
73Long palpebral fissure (HP:0000637)1.88715569
74Scapular winging (HP:0003691)1.87957730
75Natal tooth (HP:0000695)1.87125912
76Ureteral duplication (HP:0000073)1.85914564
77Abnormality of carpal bone ossification (HP:0006257)1.85004961
78Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84375858
79Abnormality of the umbilical cord (HP:0010881)1.83067273
80Popliteal pterygium (HP:0009756)1.82544786
81High anterior hairline (HP:0009890)1.82441355
82Sparse lateral eyebrow (HP:0005338)1.79374403
83Plantar hyperkeratosis (HP:0007556)1.78021683
84Progressive hearing impairment (HP:0001730)1.77275675
85Micronodular cirrhosis (HP:0001413)1.77272631
86Sensory axonal neuropathy (HP:0003390)1.77244984
87Fragile nails (HP:0001808)1.76587466
88Hypoplasia of dental enamel (HP:0006297)1.74066721
89Generalized amyotrophy (HP:0003700)1.73203904
90Poikiloderma (HP:0001029)1.71478118
91J-shaped sella turcica (HP:0002680)1.71287542
92Microretrognathia (HP:0000308)1.71085464
93Abnormalities of placenta or umbilical cord (HP:0001194)1.70609794
94Bronchomalacia (HP:0002780)1.69869904
95Cerebral aneurysm (HP:0004944)1.68429972
96Arterial tortuosity (HP:0005116)1.67942557
97Alopecia of scalp (HP:0002293)1.67914755
98Onycholysis (HP:0001806)1.67702799
99Multiple lipomas (HP:0001012)1.67294936
100Insulin resistance (HP:0000855)1.66487673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.34020358
2MST1R5.93414722
3TRIB33.78998823
4SIK13.41539802
5IRAK33.10170773
6ICK2.88994378
7MET2.84422683
8SMG12.66157712
9NME22.30107100
10EEF2K2.29163999
11LMTK22.23852130
12LATS21.95801505
13RIPK11.91563880
14PDK21.84146010
15PIM21.79240169
16PAK41.72119463
17CDK121.57713804
18LATS11.55074578
19PTK21.53903295
20ERN11.40343625
21TTN1.35261691
22EPHB21.24733700
23MTOR1.23832835
24PKN21.21412077
25MAP3K91.19827529
26RPS6KB21.18772957
27PRKG21.14630415
28PTK61.13079949
29PDGFRA1.11031050
30ARAF1.08890392
31ERBB41.08657643
32CDK81.07036973
33STK391.00298946
34PBK0.98519863
35EPHB10.96905404
36MAP3K30.93346563
37IRAK20.91723208
38MAP3K100.90746109
39NEK20.87671869
40TESK10.85389370
41MAPKAPK30.83340799
42ILK0.82068077
43PRPF4B0.78456123
44PRKD20.76797510
45MYLK0.75856314
46SCYL20.73478107
47STK380.71217453
48PRKCI0.69476697
49PDPK10.68347380
50PAK20.65073689
51BUB10.65040202
52MST40.64130046
53MELK0.63982457
54NEK60.63384242
55MAP3K10.62840586
56RPS6KA40.61086123
57MAPK110.60736508
58NTRK10.59779890
59MAP3K80.58276097
60AURKB0.57654384
61AKT20.57503191
62TESK20.56210204
63CDK70.55945060
64PRKD30.55320079
65STK38L0.52361403
66BMX0.51401325
67AURKA0.51292781
68FGFR40.47627005
69RAF10.46037071
70MAP2K20.43625349
71EIF2AK10.41009123
72CDK90.39967652
73BRAF0.39648753
74WNK40.37799233
75RPS6KA20.36610150
76TSSK60.36516899
77ABL20.35766804
78TRPM70.35700656
79TAOK20.34779308
80LRRK20.33705506
81CAMK2G0.32723698
82STK100.31657598
83TAOK10.31424459
84FER0.29383090
85CAMK2B0.28873725
86MAP3K20.28397049
87CAMK1D0.27518084
88PINK10.27508931
89MAP2K10.26849403
90MAP3K130.25360852
91TTK0.25265884
92PDGFRB0.23240761
93PAK10.23007222
94GSK3A0.22985372
95CDC42BPA0.22267963
96RPS6KB10.21510559
97DAPK30.21116930
98HIPK20.20868231
99MAPKAPK20.20397845
100RPS6KA10.18395510

Predicted pathways (KEGG)

RankGene SetZ-score
1Fructose and mannose metabolism_Homo sapiens_hsa000512.44853754
2Sulfur relay system_Homo sapiens_hsa041222.16067891
3Arginine biosynthesis_Homo sapiens_hsa002202.14421723
4Pentose phosphate pathway_Homo sapiens_hsa000302.01271309
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.91446966
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90409204
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.89108584
8Biosynthesis of amino acids_Homo sapiens_hsa012301.87211347
9Thyroid cancer_Homo sapiens_hsa052161.86681313
10ECM-receptor interaction_Homo sapiens_hsa045121.74075335
11Galactose metabolism_Homo sapiens_hsa000521.73182804
12Bladder cancer_Homo sapiens_hsa052191.73108196
13Small cell lung cancer_Homo sapiens_hsa052221.62569023
14Phenylalanine metabolism_Homo sapiens_hsa003601.60421441
15Vitamin B6 metabolism_Homo sapiens_hsa007501.55645114
16DNA replication_Homo sapiens_hsa030301.52298815
17Adherens junction_Homo sapiens_hsa045201.40289291
18Focal adhesion_Homo sapiens_hsa045101.39305002
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37994212
20Chronic myeloid leukemia_Homo sapiens_hsa052201.34030313
21Hippo signaling pathway_Homo sapiens_hsa043901.32155236
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28528453
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27248473
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25979125
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25437869
26Tight junction_Homo sapiens_hsa045301.24033832
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23030835
28Fatty acid biosynthesis_Homo sapiens_hsa000611.15583453
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13638242
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13077727
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12585266
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10211190
33Proteoglycans in cancer_Homo sapiens_hsa052051.09393930
34AMPK signaling pathway_Homo sapiens_hsa041521.09362352
35Carbon metabolism_Homo sapiens_hsa012001.07826491
36Endometrial cancer_Homo sapiens_hsa052131.07623447
37Pyruvate metabolism_Homo sapiens_hsa006201.06775115
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03594574
39Bile secretion_Homo sapiens_hsa049761.03332681
40MicroRNAs in cancer_Homo sapiens_hsa052061.00696416
41Folate biosynthesis_Homo sapiens_hsa007900.99021530
42Protein digestion and absorption_Homo sapiens_hsa049740.97903614
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97902626
44N-Glycan biosynthesis_Homo sapiens_hsa005100.95692574
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95635404
46TGF-beta signaling pathway_Homo sapiens_hsa043500.95164222
47Notch signaling pathway_Homo sapiens_hsa043300.94169044
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93891772
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93834360
50Glucagon signaling pathway_Homo sapiens_hsa049220.93790155
51Insulin signaling pathway_Homo sapiens_hsa049100.93545067
52Insulin resistance_Homo sapiens_hsa049310.92169905
53Vitamin digestion and absorption_Homo sapiens_hsa049770.90548790
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.87019839
55Starch and sucrose metabolism_Homo sapiens_hsa005000.85796284
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84046432
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83742436
58Histidine metabolism_Homo sapiens_hsa003400.83094286
59mTOR signaling pathway_Homo sapiens_hsa041500.82375954
60Sulfur metabolism_Homo sapiens_hsa009200.80984461
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77361112
62Pancreatic cancer_Homo sapiens_hsa052120.74825673
63Lysine degradation_Homo sapiens_hsa003100.74113995
64Arginine and proline metabolism_Homo sapiens_hsa003300.73349565
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72365049
66Prion diseases_Homo sapiens_hsa050200.71057978
67Cell cycle_Homo sapiens_hsa041100.70890327
68Apoptosis_Homo sapiens_hsa042100.68968840
69Pyrimidine metabolism_Homo sapiens_hsa002400.68964675
70Tyrosine metabolism_Homo sapiens_hsa003500.68685661
71Fat digestion and absorption_Homo sapiens_hsa049750.67001471
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66500007
73Basal cell carcinoma_Homo sapiens_hsa052170.66499943
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65389887
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.65243641
76Renin-angiotensin system_Homo sapiens_hsa046140.64981690
77Glutathione metabolism_Homo sapiens_hsa004800.64949424
78ErbB signaling pathway_Homo sapiens_hsa040120.64920605
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64159107
80Melanoma_Homo sapiens_hsa052180.62783002
81Hepatitis C_Homo sapiens_hsa051600.62474693
82Prostate cancer_Homo sapiens_hsa052150.62180565
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62120538
84Pancreatic secretion_Homo sapiens_hsa049720.61057990
85Other glycan degradation_Homo sapiens_hsa005110.60888456
86Hedgehog signaling pathway_Homo sapiens_hsa043400.60158868
87Gap junction_Homo sapiens_hsa045400.59810849
88Non-small cell lung cancer_Homo sapiens_hsa052230.58407305
89Glioma_Homo sapiens_hsa052140.58340307
90PPAR signaling pathway_Homo sapiens_hsa033200.56983936
91VEGF signaling pathway_Homo sapiens_hsa043700.55743604
92Thyroid hormone synthesis_Homo sapiens_hsa049180.52631122
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52159348
94Dilated cardiomyopathy_Homo sapiens_hsa054140.51358647
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.50566654
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.50434969
97Inositol phosphate metabolism_Homo sapiens_hsa005620.50317237
98Mineral absorption_Homo sapiens_hsa049780.49617537
99Amoebiasis_Homo sapiens_hsa051460.48561658
100Pathways in cancer_Homo sapiens_hsa052000.47447939

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