ZBTB48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.08239561
2neutrophil activation involved in immune response (GO:0002283)5.13288933
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94958611
4negative regulation of cell killing (GO:0031342)4.85229126
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85229126
6telomere maintenance via semi-conservative replication (GO:0032201)4.75935117
7response to peptidoglycan (GO:0032494)4.74981287
8DNA strand elongation involved in DNA replication (GO:0006271)4.55372826
9DNA strand elongation (GO:0022616)4.30885535
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30868552
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.30868552
12modulation by symbiont of host immune response (GO:0052553)4.30868552
13positive regulation by symbiont of host defense response (GO:0052509)4.30868552
14modulation by symbiont of host defense response (GO:0052031)4.30868552
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30868552
16detection of other organism (GO:0098543)4.25195663
17detection of bacterium (GO:0016045)4.24751827
18ribosomal small subunit assembly (GO:0000028)4.23270734
19immunoglobulin mediated immune response (GO:0016064)4.22802702
20antigen processing and presentation of endogenous antigen (GO:0019883)4.19862276
21viral transcription (GO:0019083)4.15026306
22glycine metabolic process (GO:0006544)4.12408733
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.05376286
24regulation of mast cell degranulation (GO:0043304)4.00065853
25translational termination (GO:0006415)3.99832050
26macrophage activation involved in immune response (GO:0002281)3.98131390
27folic acid-containing compound biosynthetic process (GO:0009396)3.91965718
28germinal center formation (GO:0002467)3.88829662
29cellular extravasation (GO:0045123)3.87212177
30telomere maintenance via recombination (GO:0000722)3.86627542
31maturation of SSU-rRNA (GO:0030490)3.86556465
32DNA unwinding involved in DNA replication (GO:0006268)3.85205433
33regulation of B cell receptor signaling pathway (GO:0050855)3.83756026
34DNA replication initiation (GO:0006270)3.82060655
35positive regulation of antigen processing and presentation (GO:0002579)3.81306260
36positive regulation of B cell differentiation (GO:0045579)3.80542005
37translational elongation (GO:0006414)3.71619586
38B cell receptor signaling pathway (GO:0050853)3.69890765
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.67192052
40nucleobase biosynthetic process (GO:0046112)3.62065363
41regulation of antigen processing and presentation (GO:0002577)3.58235366
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.55771186
43regulation of mast cell activation involved in immune response (GO:0033006)3.55098923
44mitotic recombination (GO:0006312)3.53801141
45negative regulation of interleukin-12 production (GO:0032695)3.53738603
46L-serine metabolic process (GO:0006563)3.51750108
47regulation of leukocyte degranulation (GO:0043300)3.50926317
48detection of external biotic stimulus (GO:0098581)3.50471561
49serine family amino acid biosynthetic process (GO:0009070)3.49053277
50neutrophil activation (GO:0042119)3.48659797
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47123783
52telomere maintenance via telomere lengthening (GO:0010833)3.44584958
53myeloid cell activation involved in immune response (GO:0002275)3.44119320
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43607845
55respiratory burst (GO:0045730)3.42206181
56neutrophil mediated immunity (GO:0002446)3.40441938
57NIK/NF-kappaB signaling (GO:0038061)3.39777301
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38471344
59L-phenylalanine metabolic process (GO:0006558)3.38471344
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36897661
61positive thymic T cell selection (GO:0045059)3.35877550
62positive regulation of mast cell activation (GO:0033005)3.34280994
63purine nucleobase biosynthetic process (GO:0009113)3.33286569
64translational initiation (GO:0006413)3.32220931
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.32130701
66positive regulation of mast cell degranulation (GO:0043306)3.32130701
67L-phenylalanine catabolic process (GO:0006559)3.31375649
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31375649
69regulation of B cell differentiation (GO:0045577)3.29721641
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.29229207
71cotranslational protein targeting to membrane (GO:0006613)3.26435772
72granulocyte activation (GO:0036230)3.26152047
73protein targeting to ER (GO:0045047)3.24767298
74pteridine-containing compound biosynthetic process (GO:0042559)3.23442390
75response to muramyl dipeptide (GO:0032495)3.20984624
76regulation of gamma-delta T cell differentiation (GO:0045586)3.20677627
77ribosomal small subunit biogenesis (GO:0042274)3.20171649
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20073002
79aromatic amino acid family catabolic process (GO:0009074)3.19716296
80regulation of T-helper 2 cell differentiation (GO:0045628)3.18917167
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17108905
82response to host immune response (GO:0052572)3.17108905
83mannose metabolic process (GO:0006013)3.15808792
84negative regulation of leukocyte mediated immunity (GO:0002704)3.14716488
85ribosomal large subunit biogenesis (GO:0042273)3.14149481
86regulation of interferon-beta biosynthetic process (GO:0045357)3.13352621
87serine family amino acid catabolic process (GO:0009071)3.11288794
88tryptophan catabolic process (GO:0006569)3.11106187
89indole-containing compound catabolic process (GO:0042436)3.11106187
90indolalkylamine catabolic process (GO:0046218)3.11106187
91cellular protein complex disassembly (GO:0043624)3.10836362
92detection of biotic stimulus (GO:0009595)3.10530400
93folic acid metabolic process (GO:0046655)3.10259932
94regulation of mast cell activation (GO:0033003)3.09473287
95protein localization to endoplasmic reticulum (GO:0070972)3.06124382
96B cell mediated immunity (GO:0019724)3.05115467
97establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04558417
98negative thymic T cell selection (GO:0045060)3.04528826
99leukocyte aggregation (GO:0070486)3.03881241
100protein localization to kinetochore (GO:0034501)3.02665942
101serine family amino acid metabolic process (GO:0009069)3.02396730
102macrophage activation (GO:0042116)3.00860954
103rRNA processing (GO:0006364)3.00740160
104viral life cycle (GO:0019058)3.00273713
105kynurenine metabolic process (GO:0070189)2.99822778
106ribonucleoprotein complex biogenesis (GO:0022613)2.99368107
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98110497
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97905601
109DNA replication checkpoint (GO:0000076)2.95933949
110ribosome biogenesis (GO:0042254)2.95129637
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94783574
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93711890
113pseudouridine synthesis (GO:0001522)2.93536492
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92829036
115detection of molecule of bacterial origin (GO:0032490)2.92751986
116N-acetylneuraminate metabolic process (GO:0006054)2.91295781
117mitochondrial DNA replication (GO:0006264)2.91229724
118rRNA metabolic process (GO:0016072)2.90752667
119pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.90410432
120T cell selection (GO:0045058)2.89452124
121nucleoside salvage (GO:0043174)2.89418185
122response to host defenses (GO:0052200)2.88593296
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88593296
124response to host (GO:0075136)2.88593296
125tryptophan metabolic process (GO:0006568)2.87775462
126imidazole-containing compound metabolic process (GO:0052803)2.85820627
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85713612
128one-carbon metabolic process (GO:0006730)2.85580889
129tetrahydrofolate metabolic process (GO:0046653)2.85551177
130positive regulation of chemokine secretion (GO:0090197)2.85344123
131thymic T cell selection (GO:0045061)2.84878445
132protein complex disassembly (GO:0043241)2.84810400
133regulation of gamma-delta T cell activation (GO:0046643)2.84775815
134defense response to protozoan (GO:0042832)2.82152129
135mitochondrial DNA metabolic process (GO:0032042)2.81911910
136glyoxylate metabolic process (GO:0046487)2.81021719
137microglial cell activation (GO:0001774)2.80559115
138positive regulation of granulocyte differentiation (GO:0030854)2.79860661
139amino sugar catabolic process (GO:0046348)2.79465399
140positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.79250720
141positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78644252
142chromatin remodeling at centromere (GO:0031055)2.78253175
143response to protozoan (GO:0001562)2.78162908
144CENP-A containing nucleosome assembly (GO:0034080)2.77199117
145regulation of regulated secretory pathway (GO:1903305)2.76137372
146myeloid leukocyte mediated immunity (GO:0002444)2.74785371
147myeloid dendritic cell activation (GO:0001773)2.74371764
148pinocytosis (GO:0006907)2.74221150
149pyrimidine nucleoside salvage (GO:0043097)2.73885511
150pyrimidine-containing compound salvage (GO:0008655)2.73885511
151pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.73620516
152negative regulation of innate immune response (GO:0045824)2.73558959
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73142034
154negative T cell selection (GO:0043383)2.73126395
155formation of translation preinitiation complex (GO:0001731)2.71560760
156macromolecular complex disassembly (GO:0032984)2.69153339
157negative regulation of T cell mediated immunity (GO:0002710)2.68963199
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68785873
159negative regulation of T-helper cell differentiation (GO:0045623)2.68785873
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68330693
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68330693
162response to type I interferon (GO:0034340)2.68092201
163regulation of granulocyte differentiation (GO:0030852)2.67055555
164diterpenoid biosynthetic process (GO:0016102)2.66877750
165type I interferon signaling pathway (GO:0060337)2.64618411
166cellular response to type I interferon (GO:0071357)2.64618411
167negative regulation of alpha-beta T cell activation (GO:0046636)2.64553379
168negative regulation of RNA splicing (GO:0033119)2.64144307
169protein localization to chromosome, centromeric region (GO:0071459)2.63589572
170nuclear-transcribed mRNA catabolic process (GO:0000956)2.62928436
171leukocyte degranulation (GO:0043299)2.62566774
172IMP biosynthetic process (GO:0006188)2.59009911
173ribosome assembly (GO:0042255)2.56701450
174translation (GO:0006412)2.56230316
175positive regulation of gamma-delta T cell activation (GO:0046645)2.56018374
176DNA replication-independent nucleosome organization (GO:0034724)2.55354154
177DNA replication-independent nucleosome assembly (GO:0006336)2.55354154
178sulfur amino acid catabolic process (GO:0000098)2.55313134
179spliceosomal snRNP assembly (GO:0000387)2.53010291
180pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.52397919
181UMP metabolic process (GO:0046049)2.52397919
182pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.52397919
183UMP biosynthetic process (GO:0006222)2.52397919
184folic acid-containing compound metabolic process (GO:0006760)2.51354211
185proline metabolic process (GO:0006560)2.48474740
186mRNA catabolic process (GO:0006402)2.48267271
187histone H2A acetylation (GO:0043968)2.46519290
188pyrimidine nucleobase metabolic process (GO:0006206)2.46379785
189mitochondrial RNA metabolic process (GO:0000959)2.46164912
190RNA catabolic process (GO:0006401)2.45808427
191negative regulation of cholesterol transport (GO:0032375)2.45434127
192negative regulation of sterol transport (GO:0032372)2.45434127
193negative regulation of erythrocyte differentiation (GO:0045647)2.45124430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13634994
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58641761
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.43150944
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.98748353
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95516975
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.72950089
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63949488
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61814656
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.47835082
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46974317
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45801824
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.40467596
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40300505
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35128781
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.31495980
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30004021
17MYC_22102868_ChIP-Seq_BL_Human2.26340159
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25983456
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19511957
20LXR_22292898_ChIP-Seq_THP-1_Human2.19188093
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18678411
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17919007
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17277371
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16899417
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13500706
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12301486
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11153499
28XRN2_22483619_ChIP-Seq_HELA_Human2.08321792
29* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00203794
30* KDM2B_26808549_Chip-Seq_DND41_Human1.98711007
31CIITA_25753668_ChIP-Seq_RAJI_Human1.97919838
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96221662
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95665294
34* VDR_21846776_ChIP-Seq_THP-1_Human1.94938950
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92314592
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90306815
37* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87122540
38VDR_23849224_ChIP-Seq_CD4+_Human1.86841259
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.86833073
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86551754
41* RXR_22158963_ChIP-Seq_LIVER_Mouse1.85646298
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84208645
43SPI1_23127762_ChIP-Seq_K562_Human1.82992130
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.82413488
45FOXP3_21729870_ChIP-Seq_TREG_Human1.78735337
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78330667
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77454709
48GABP_19822575_ChIP-Seq_HepG2_Human1.76435803
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75662618
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74940396
51DCP1A_22483619_ChIP-Seq_HELA_Human1.74118510
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73127666
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72290811
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67849499
55BCL6_27268052_Chip-Seq_Bcells_Human1.65523940
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64695436
57P68_20966046_ChIP-Seq_HELA_Human1.64317594
58BCOR_27268052_Chip-Seq_Bcells_Human1.63298750
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.58530194
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57377787
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54900922
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54585188
63MYB_26560356_Chip-Seq_TH2_Human1.53848691
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53567428
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53013945
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.51105218
67* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50065431
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.49206749
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49099315
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48638520
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47706566
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47603665
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47446125
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47140153
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46864768
76* NCOR1_26117541_ChIP-Seq_K562_Human1.46627454
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45123444
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44822076
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43151300
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.43063638
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42683215
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.42553953
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42230029
84RACK7_27058665_Chip-Seq_MCF-7_Human1.41879386
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40087617
86* KDM5A_27292631_Chip-Seq_BREAST_Human1.38058994
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37513093
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35638003
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35572853
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35029971
91TTF2_22483619_ChIP-Seq_HELA_Human1.34920772
92RUNX_20019798_ChIP-Seq_JUKART_Human1.33885238
93* E2F1_21310950_ChIP-Seq_MCF-7_Human1.33552458
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28714341
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28576759
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27304476
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26553467
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26532583
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.25906404
100SCL_19346495_ChIP-Seq_HPC-7_Human1.25480858
101AR_21909140_ChIP-Seq_LNCAP_Human1.25141519
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24948957
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24620228
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23747225
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23611517
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23364137
107IRF8_22096565_ChIP-ChIP_GC-B_Human1.22602600
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22334852
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22321342
110GATA1_19941826_ChIP-Seq_K562_Human1.22096117
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21477653
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21222879
113E2F1_20622854_ChIP-Seq_HELA_Human1.20788437
114PHF8_20622854_ChIP-Seq_HELA_Human1.20457891
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20092101
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.20078795
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19928502
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19004375
119UTX_26944678_Chip-Seq_JUKART_Human1.17337374
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16934297
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16898241
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16638925
123SMC4_20622854_ChIP-Seq_HELA_Human1.16458696
124* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15617080
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15451754
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14966148
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14535438
128SPI1_23547873_ChIP-Seq_NB4_Human1.13951003
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12924196
130CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12754334
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12411365
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10110305
133* MAF_26560356_Chip-Seq_TH1_Human1.09597700
134CTCF_26484167_Chip-Seq_Bcells_Mouse1.09572720
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08827405
136YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08108880
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07001103
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06354429
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04397183
140GATA3_27048872_Chip-Seq_THYMUS_Human1.03690551
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03665284
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03403987
143* SA1_27219007_Chip-Seq_Bcells_Human1.03143230
144P300_27268052_Chip-Seq_Bcells_Human1.02392635
145* ETS1_21867929_ChIP-Seq_TH2_Mouse1.00796798
146* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00673843
147* MAF_26560356_Chip-Seq_TH2_Human1.00643375
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00274658
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99819258
150CTCF_21964334_Chip-Seq_Bcells_Human0.99628093
151LXR_22158963_ChIP-Seq_LIVER_Mouse0.97951144
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96891573
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95738160
154VDR_24763502_ChIP-Seq_THP-1_Human0.95307956
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95303663
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94607314
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.92994404
158CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92645753
159MYB_26560356_Chip-Seq_TH1_Human0.92146221
160TCF7_22412390_ChIP-Seq_EML_Mouse0.91882455
161GATA1_22025678_ChIP-Seq_K562_Human0.90752421
162NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90657669
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.90343020
164FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90298456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.15480598
2MP0002139_abnormal_hepatobiliary_system3.95248175
3MP0003303_peritoneal_inflammation3.73027085
4MP0003693_abnormal_embryo_hatching3.53448142
5MP0005085_abnormal_gallbladder_physiolo3.28741747
6MP0003806_abnormal_nucleotide_metabolis3.16661068
7MP0005365_abnormal_bile_salt3.12491216
8MP0008260_abnormal_autophagy3.08580330
9MP0005058_abnormal_lysosome_morphology3.08424552
10MP0003724_increased_susceptibility_to3.05263964
11MP0009840_abnormal_foam_cell2.96454852
12MP0010094_abnormal_chromosome_stability2.81799674
13MP0009278_abnormal_bone_marrow2.80094288
14MP0002396_abnormal_hematopoietic_system2.77774312
15MP0002419_abnormal_innate_immunity2.77081471
16MP0004957_abnormal_blastocyst_morpholog2.76224225
17MP0008057_abnormal_DNA_replication2.70509618
18MP0008875_abnormal_xenobiotic_pharmacok2.64824148
19MP0003111_abnormal_nucleus_morphology2.57281423
20MP0003763_abnormal_thymus_physiology2.47774528
21MP0003077_abnormal_cell_cycle2.38097611
22MP0002148_abnormal_hypersensitivity_rea2.30511233
23MP0003252_abnormal_bile_duct2.29394055
24MP0006082_CNS_inflammation1.94766519
25MP0000685_abnormal_immune_system1.83344553
26MP0008058_abnormal_DNA_repair1.78306757
27MP0003183_abnormal_peptide_metabolism1.78178451
28MP0010329_abnormal_lipoprotein_level1.75139598
29MP0008007_abnormal_cellular_replicative1.73099845
30MP0004947_skin_inflammation1.68181975
31MP0005075_abnormal_melanosome_morpholog1.67561034
32MP0005083_abnormal_biliary_tract1.66007678
33MP0000609_abnormal_liver_physiology1.63914873
34MP0002398_abnormal_bone_marrow1.61265582
35MP0001533_abnormal_skeleton_physiology1.57459626
36MP0009764_decreased_sensitivity_to1.56364351
37MP0003656_abnormal_erythrocyte_physiolo1.55202963
38MP0000689_abnormal_spleen_morphology1.52445510
39MP0002722_abnormal_immune_system1.48263412
40MP0005464_abnormal_platelet_physiology1.46365050
41MP0001800_abnormal_humoral_immune1.45590271
42MP0003436_decreased_susceptibility_to1.43222461
43MP0005671_abnormal_response_to1.42596825
44MP0001545_abnormal_hematopoietic_system1.41089515
45MP0005397_hematopoietic_system_phenotyp1.41089515
46MP0005332_abnormal_amino_acid1.40849901
47MP0000858_altered_metastatic_potential1.39123126
48MP0000490_abnormal_crypts_of1.38566117
49MP0003868_abnormal_feces_composition1.36889180
50MP0003828_pulmonary_edema1.36203367
51MP0002019_abnormal_tumor_incidence1.36069627
52MP0004808_abnormal_hematopoietic_stem1.33784207
53MP0009333_abnormal_splenocyte_physiolog1.32178062
54MP0001764_abnormal_homeostasis1.32110655
55MP0001835_abnormal_antigen_presentation1.31857503
56MP0002429_abnormal_blood_cell1.30615706
57MP0003191_abnormal_cellular_cholesterol1.30244747
58MP0002166_altered_tumor_susceptibility1.29760998
59MP0001730_embryonic_growth_arrest1.29697254
60MP0001986_abnormal_taste_sensitivity1.29167650
61MP0000716_abnormal_immune_system1.28155986
62MP0000703_abnormal_thymus_morphology1.28036599
63MP0000350_abnormal_cell_proliferation1.27133848
64MP0006036_abnormal_mitochondrial_physio1.25995530
65MP0005025_abnormal_response_to1.25552207
66MP0003718_maternal_effect1.24533853
67MP0005319_abnormal_enzyme/_coenzyme1.23938041
68MP0005310_abnormal_salivary_gland1.23061488
69MP0000598_abnormal_liver_morphology1.21008107
70MP0003866_abnormal_defecation1.19377697
71MP0002723_abnormal_immune_serum1.19076277
72MP0010155_abnormal_intestine_physiology1.19010525
73MP0009785_altered_susceptibility_to1.18944793
74MP0003075_altered_response_to1.16438017
75MP0002420_abnormal_adaptive_immunity1.14288168
76MP0001819_abnormal_immune_cell1.11981783
77MP0001666_abnormal_nutrient_absorption1.11303219
78MP0005076_abnormal_cell_differentiation1.10928808
79MP0008469_abnormal_protein_level1.06597953
80MP0004381_abnormal_hair_follicle1.05886852
81MP0002998_abnormal_bone_remodeling1.05600287
82MP0002928_abnormal_bile_duct1.05147068
83MP0001873_stomach_inflammation1.04510303
84MP0000313_abnormal_cell_death1.04109425
85MP0002452_abnormal_antigen_presenting1.01354589
86MP0008932_abnormal_embryonic_tissue1.01084031
87MP0000477_abnormal_intestine_morphology0.98644518
88MP0003786_premature_aging0.97682845
89MP0001790_abnormal_immune_system0.97372596
90MP0005387_immune_system_phenotype0.97372596
91MP0002080_prenatal_lethality0.97070573
92MP0001663_abnormal_digestive_system0.93979323
93MP0005584_abnormal_enzyme/coenzyme_acti0.93932421
94MP0000015_abnormal_ear_pigmentation0.92898388
95MP0004510_myositis0.92474513
96MP0005408_hypopigmentation0.91775352
97MP0000604_amyloidosis0.91345924
98MP0002118_abnormal_lipid_homeostasis0.88938173
99MP0005220_abnormal_exocrine_pancreas0.86972990
100MP0000678_abnormal_parathyroid_gland0.86900381
101MP0005451_abnormal_body_composition0.86369503
102MP0003453_abnormal_keratinocyte_physiol0.85899251
103MP0009763_increased_sensitivity_to0.85730025
104MP0001845_abnormal_inflammatory_respons0.85727944
105MP0001853_heart_inflammation0.85447332
106MP0005000_abnormal_immune_tolerance0.84795444
107MP0001697_abnormal_embryo_size0.84231429
108MP0009643_abnormal_urine_homeostasis0.83630376
109MP0005380_embryogenesis_phenotype0.83437087
110MP0001672_abnormal_embryogenesis/_devel0.83437087
111MP0006035_abnormal_mitochondrial_morpho0.83365529
112MP0009379_abnormal_foot_pigmentation0.82117663
113MP0008877_abnormal_DNA_methylation0.81955629
114MP0002132_abnormal_respiratory_system0.81172385
115MP0000465_gastrointestinal_hemorrhage0.81112080
116MP0002095_abnormal_skin_pigmentation0.80527574
117MP0001851_eye_inflammation0.80425335
118MP0002138_abnormal_hepatobiliary_system0.79510477
119MP0003567_abnormal_fetal_cardiomyocyte0.78961630
120MP0005166_decreased_susceptibility_to0.78504593
121MP0005167_abnormal_blood-brain_barrier0.75981017
122MP0003186_abnormal_redox_activity0.75963235
123MP0004185_abnormal_adipocyte_glucose0.75445505
124MP0003123_paternal_imprinting0.73996276
125MP0002405_respiratory_system_inflammati0.73520505
126MP0005636_abnormal_mineral_homeostasis0.73387607
127MP0003984_embryonic_growth_retardation0.72604665
128MP0005174_abnormal_tail_pigmentation0.72481283
129MP0003172_abnormal_lysosome_physiology0.72416702
130MP0001929_abnormal_gametogenesis0.71369073
131MP0003300_gastrointestinal_ulcer0.70751507
132MP0003795_abnormal_bone_structure0.68632985
133MP0004883_abnormal_blood_vessel0.67245747
134MP0002277_abnormal_respiratory_mucosa0.64152339
135MP0000343_altered_response_to0.63737891
136MP0005390_skeleton_phenotype0.63374863
137MP0002933_joint_inflammation0.63087484
138MP0005666_abnormal_adipose_tissue0.62433828
139MP0005164_abnormal_response_to0.58876659
140MP0000249_abnormal_blood_vessel0.58313848
141MP0000358_abnormal_cell_content/0.57884917
142MP0003690_abnormal_glial_cell0.55582432
143MP0009931_abnormal_skin_appearance0.54653921

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.33107114
2Recurrent abscess formation (HP:0002722)5.20948807
3Recurrent bacterial skin infections (HP:0005406)5.12704065
4Abnormality of macrophages (HP:0004311)4.61470846
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.56377513
6Abnormality of cells of the erythroid lineage (HP:0012130)4.50888346
7Recurrent gram-negative bacterial infections (HP:0005420)4.25246375
8Abnormal number of erythroid precursors (HP:0012131)4.22623114
9Chronic obstructive pulmonary disease (HP:0006510)4.09401345
10Obstructive lung disease (HP:0006536)4.09401345
11Myositis (HP:0100614)4.03471024
12Mediastinal lymphadenopathy (HP:0100721)3.88840047
13Hypobetalipoproteinemia (HP:0003563)3.79020670
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76803762
15Abnormality of the fingertips (HP:0001211)3.69196927
16Oral leukoplakia (HP:0002745)3.67627294
17Abnormality of glycolipid metabolism (HP:0010969)3.61265605
18Abnormality of liposaccharide metabolism (HP:0010968)3.61265605
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.61265605
20Prolonged partial thromboplastin time (HP:0003645)3.56962602
21Meningitis (HP:0001287)3.54218133
22Aplastic anemia (HP:0001915)3.50351233
23Deep venous thrombosis (HP:0002625)3.48522071
24Recurrent fungal infections (HP:0002841)3.46105938
25Abnormality of pyrimidine metabolism (HP:0004353)3.36293638
26IgM deficiency (HP:0002850)3.34840953
27Gastrointestinal inflammation (HP:0004386)3.26898977
28Recurrent skin infections (HP:0001581)3.25872096
29Dysostosis multiplex (HP:0000943)3.23637188
30Reticulocytopenia (HP:0001896)3.23125537
31Intrahepatic cholestasis (HP:0001406)3.21044237
32Orchitis (HP:0100796)3.13790469
33Cellulitis (HP:0100658)3.11991175
34Pustule (HP:0200039)3.10719530
35Increased cerebral lipofuscin (HP:0011813)3.09204084
36Colitis (HP:0002583)3.04079588
37Inflammation of the large intestine (HP:0002037)3.02038935
38Stomatitis (HP:0010280)2.96484607
39Hyperglycinemia (HP:0002154)2.96030989
40Birth length less than 3rd percentile (HP:0003561)2.95339421
41Xanthomatosis (HP:0000991)2.95304225
42Gastrointestinal infarctions (HP:0005244)2.94067261
43Abnormality of lateral ventricle (HP:0030047)2.93761933
44Loss of speech (HP:0002371)2.93691028
45Macrocytic anemia (HP:0001972)2.88215029
46Increased IgE level (HP:0003212)2.83255711
47Optic neuritis (HP:0100653)2.82340235
48Retrobulbar optic neuritis (HP:0100654)2.82340235
49Chronic mucocutaneous candidiasis (HP:0002728)2.81113662
50Recurrent cutaneous fungal infections (HP:0011370)2.81113662
51Vacuolated lymphocytes (HP:0001922)2.78656001
52Vasculitis (HP:0002633)2.78183159
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.71345430
54Gingivitis (HP:0000230)2.70788738
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.70687969
56Encephalitis (HP:0002383)2.70029548
57Agammaglobulinemia (HP:0004432)2.69574599
58Recurrent viral infections (HP:0004429)2.68193798
59Hyperlipoproteinemia (HP:0010980)2.67767448
60Broad distal phalanx of finger (HP:0009836)2.66561968
61Thrombocytosis (HP:0001894)2.66231926
62Systemic lupus erythematosus (HP:0002725)2.65325168
63Granulocytopenia (HP:0001913)2.65007933
64Elevated erythrocyte sedimentation rate (HP:0003565)2.63192376
65Urticaria (HP:0001025)2.61424470
66Hyperglycinuria (HP:0003108)2.61175996
67Purpura (HP:0000979)2.61049394
68Abnormality of T cell physiology (HP:0011840)2.56918279
69Chest pain (HP:0100749)2.54281023
70Deep palmar crease (HP:0006191)2.53637310
71Multiple enchondromatosis (HP:0005701)2.53193077
72Spontaneous hematomas (HP:0007420)2.50235932
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49918121
74Hypochromic anemia (HP:0001931)2.49789850
75Abnormality of polysaccharide metabolism (HP:0011012)2.48671135
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48671135
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48671135
78Hyperammonemia (HP:0001987)2.48392830
79Hyperbilirubinemia (HP:0002904)2.48148560
80Selective tooth agenesis (HP:0001592)2.46438257
81Abnormality of glycine metabolism (HP:0010895)2.45212730
82Abnormality of serine family amino acid metabolism (HP:0010894)2.45212730
83Premature graying of hair (HP:0002216)2.44103331
84Hemorrhage of the eye (HP:0011885)2.43818364
85Recurrent bronchitis (HP:0002837)2.42759471
86Pallor (HP:0000980)2.39631435
87Abnormality of T cells (HP:0002843)2.36808047
88Abnormality of cochlea (HP:0000375)2.36491466
89Dicarboxylic aciduria (HP:0003215)2.35189704
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35189704
91Type I transferrin isoform profile (HP:0003642)2.33698684
92Joint hemorrhage (HP:0005261)2.33165133
93Hemoptysis (HP:0002105)2.31009710
94Ketosis (HP:0001946)2.30555086
95Spastic diplegia (HP:0001264)2.28652333
96Keratoconjunctivitis sicca (HP:0001097)2.28444879
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.27937051
98Hypoplasia of the thymus (HP:0000778)2.27928320
99Impulsivity (HP:0100710)2.27511053
100Increased IgM level (HP:0003496)2.26631159
101Osteomyelitis (HP:0002754)2.26171063
102Abnormality of sulfur amino acid metabolism (HP:0004339)2.25425180
103Abnormality of the common coagulation pathway (HP:0010990)2.24147403
104Hypertensive crisis (HP:0100735)2.20787799
105Hepatosplenomegaly (HP:0001433)2.20657614
106Acute lymphatic leukemia (HP:0006721)2.19886698
107Hepatic necrosis (HP:0002605)2.18483807
108Abnormality of serum amino acid levels (HP:0003112)2.17621712
109Mucopolysacchariduria (HP:0008155)2.16790408
110Urinary glycosaminoglycan excretion (HP:0003541)2.16790408
111Ependymoma (HP:0002888)2.15741982
112Hepatocellular necrosis (HP:0001404)2.14571950
113Thoracic kyphosis (HP:0002942)2.13414556
114Abnormality of fatty-acid metabolism (HP:0004359)2.11790674
115Acanthocytosis (HP:0001927)2.11637146
116Neuronal loss in central nervous system (HP:0002529)2.11514996
117Cellular immunodeficiency (HP:0005374)2.11158456
118Chronic otitis media (HP:0000389)2.10156765
119Colon cancer (HP:0003003)2.09933927
120Poikilocytosis (HP:0004447)2.07354306
121Delayed epiphyseal ossification (HP:0002663)2.06861349
122Brushfield spots (HP:0001088)2.06100553
123Nasal polyposis (HP:0100582)2.05962601
124Combined immunodeficiency (HP:0005387)2.05936756
125Opisthotonus (HP:0002179)2.05900792
126Pancytopenia (HP:0001876)2.05218485
127Reduced antithrombin III activity (HP:0001976)2.05158180
128Dynein arm defect of respiratory motile cilia (HP:0012255)2.04101884
129Absent/shortened dynein arms (HP:0200106)2.04101884
130Hypolipoproteinemia (HP:0010981)2.04064491
131Cerebral hypomyelination (HP:0006808)2.03140789
132Metaphyseal cupping (HP:0003021)2.03049686
133Abnormality of reticulocytes (HP:0004312)2.02569009
134Autoimmune thrombocytopenia (HP:0001973)2.01545315
135Disinhibition (HP:0000734)2.01454419
136Abnormality of the nasal mucosa (HP:0000433)2.00997478
137Epistaxis (HP:0000421)2.00704954
138Microretrognathia (HP:0000308)2.00492463
139Gastrointestinal stroma tumor (HP:0100723)1.99803251
140Leukocytosis (HP:0001974)1.98826146
141Basal cell carcinoma (HP:0002671)1.98297316
142Abnormality of B cell number (HP:0010975)1.97710544
143B lymphocytopenia (HP:0010976)1.97710544
144Abnormality of cells of the lymphoid lineage (HP:0012140)1.97461721
145Keratoconjunctivitis (HP:0001096)1.97287919
146Abnormality of methionine metabolism (HP:0010901)1.96504122
147Progressive muscle weakness (HP:0003323)1.96312053
148Personality changes (HP:0000751)1.96197993
149Abnormality of nucleobase metabolism (HP:0010932)1.95432885
150Bone marrow hypocellularity (HP:0005528)1.95235748
151Papilloma (HP:0012740)1.94802193
152Verrucae (HP:0200043)1.94802193
153Pulmonary infiltrates (HP:0002113)1.94307190
154Lymphopenia (HP:0001888)1.94164802
155Panhypogammaglobulinemia (HP:0003139)1.92456468
156Sepsis (HP:0100806)1.92442020
157Polygenic inheritance (HP:0010982)1.92287448
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91730121
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91730121
160Prolonged bleeding time (HP:0003010)1.91241224
161Slow saccadic eye movements (HP:0000514)1.91193754
162Late onset (HP:0003584)1.90293726
163Ragged-red muscle fibers (HP:0003200)1.90149108
164Delayed CNS myelination (HP:0002188)1.89715539
165Complement deficiency (HP:0004431)1.89421370
166Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88306383
167Rough bone trabeculation (HP:0100670)1.88160081
168Malnutrition (HP:0004395)1.87720408
169Restrictive lung disease (HP:0002091)1.87372940
170Abnormality of the intrinsic pathway (HP:0010989)1.84840045
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84671723
172Lymphoma (HP:0002665)1.84508828
173Abnormality of the thoracic spine (HP:0100711)1.82557676
174Petechiae (HP:0000967)1.82081536
175Microcytic anemia (HP:0001935)1.81261271
176Increased serum ferritin (HP:0003281)1.81190014
177IgG deficiency (HP:0004315)1.80704767
178Megaloblastic anemia (HP:0001889)1.80453449
179Death in childhood (HP:0003819)1.79371341
180Gingival bleeding (HP:0000225)1.78273566
181Recurrent sinusitis (HP:0011108)1.76449694
182Abnormality of iron homeostasis (HP:0011031)1.76090301
183Increased serum lactate (HP:0002151)1.75972566
184Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75899193
185Lethargy (HP:0001254)1.75709919
18611 pairs of ribs (HP:0000878)1.75369883
187Gout (HP:0001997)1.75162168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.82398714
2ACVR1B3.73245235
3BUB13.46502846
4WEE13.29156890
5MAP3K103.11739571
6MAP4K13.10211408
7ERN12.96511557
8BCKDK2.84546892
9FLT32.80075914
10NME22.60877884
11EIF2AK12.42792104
12PRPF4B2.33465003
13KIT2.18738063
14TNK22.09492805
15FES2.05534544
16STK162.05187636
17CDK42.00843133
18SCYL21.92234006
19CDC71.89172637
20CSK1.74479656
21KDR1.72836753
22PKN21.70972675
23NEK21.70365951
24SIK31.66839861
25MAP3K141.63340690
26EEF2K1.63171214
27SRPK11.62280982
28MAP3K131.61193067
29TESK21.54042429
30CSF1R1.52835446
31SMG11.51711615
32TRIB31.50007135
33TEC1.48077935
34GRK61.44845208
35ZAP701.44663191
36MARK21.44405292
37TGFBR11.42623625
38IRAK31.41071120
39HCK1.38160880
40TLK11.37131850
41BTK1.36548420
42MAP3K71.35105343
43EIF2AK31.31337950
44RAF11.30646889
45TYK21.26641587
46DYRK31.24121853
47CDK71.23279372
48CCNB11.21237324
49TSSK61.19374975
50TTK1.17969009
51KSR21.14779892
52TAOK21.14378631
53MAP3K31.14265775
54PLK11.14122683
55MATK1.11548817
56PRKD21.04950986
57SIK11.04699434
58STK101.04293043
59IRAK21.02397444
60MARK31.01496889
61STK381.01386143
62JAK21.00069151
63STK38L0.99668429
64FGR0.98528492
65MAP3K10.97418965
66FGFR40.96986372
67RPS6KB20.96326628
68AURKB0.95927487
69TBK10.94923626
70ILK0.94499438
71ATR0.93264885
72MAP2K20.92101135
73PIM20.88891961
74RPS6KL10.88724451
75RPS6KC10.88724451
76PASK0.88634200
77CHEK20.87753422
78TAOK30.83886717
79MAPK110.83179686
80SYK0.82779373
81NUAK10.80536692
82VRK10.76324450
83RPS6KA60.76089585
84AURKA0.74828180
85CDK190.74711871
86BRAF0.74096460
87LRRK20.73563675
88TXK0.73094418
89IKBKE0.71641277
90MAP3K80.70382950
91TESK10.69564664
92PDPK10.68259559
93MAP2K30.67585123
94CDC42BPA0.66723047
95HIPK20.65965969
96CDK80.65432774
97IRAK10.65362117
98PDK10.63415624
99DYRK1B0.61179187
100BLK0.60706675
101MAPK120.60557141
102BRSK20.60489801
103MAP3K110.59639284
104PTK60.58762491
105PIK3CA0.58704530
106PAK40.58528514
107PIM10.57175348
108NEK90.56913558
109CHEK10.56494529
110CDK60.55698230
111LCK0.55471114
112CSNK2A20.55362903
113DAPK10.55151534
114CDK120.54733519
115LYN0.54166580
116EPHB10.53101949
117IKBKB0.52813409
118STK40.52669642
119WNK10.51811792
120MAPK70.51326368
121TNIK0.50967056
122RPS6KA20.50600775
123TGFBR20.50535427
124MAPK40.49993519
125CDK20.49948286
126RPS6KA40.49787793
127JAK30.47618752
128MAP2K60.46307881
129CSNK2A10.44992227
130NLK0.44134513
131ITK0.43999412
132BRD40.42242071
133CLK10.40349884
134IRAK40.39114414
135BRSK10.38004477
136MTOR0.37926593
137ICK0.37474840
138FYN0.36871752
139RPS6KA10.36226587
140TAOK10.35970775
141RIPK10.35735214
142MAPK150.35355590
143PAK10.35261451
144MAP3K60.34450478
145SIK20.34287518
146MAPK30.33540202
147PTK2B0.29549185
148MAPK80.29324218
149JAK10.29124863

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47964992
2Mismatch repair_Homo sapiens_hsa034303.70114672
3Other glycan degradation_Homo sapiens_hsa005113.47725293
4Ribosome_Homo sapiens_hsa030103.14345238
5Leishmaniasis_Homo sapiens_hsa051402.89762018
6Osteoclast differentiation_Homo sapiens_hsa043802.84564037
7Homologous recombination_Homo sapiens_hsa034402.61801174
8Base excision repair_Homo sapiens_hsa034102.41953360
9Allograft rejection_Homo sapiens_hsa053302.39407360
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.37777627
11One carbon pool by folate_Homo sapiens_hsa006702.32749654
12Spliceosome_Homo sapiens_hsa030402.25031981
13Pyrimidine metabolism_Homo sapiens_hsa002402.22593782
14Graft-versus-host disease_Homo sapiens_hsa053322.22235145
15Autoimmune thyroid disease_Homo sapiens_hsa053202.17770216
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.15030095
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09728713
18Selenocompound metabolism_Homo sapiens_hsa004502.02039898
19Tuberculosis_Homo sapiens_hsa051522.00749736
20Sulfur relay system_Homo sapiens_hsa041221.98742507
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96717973
22Nucleotide excision repair_Homo sapiens_hsa034201.94819153
23Proteasome_Homo sapiens_hsa030501.92129298
24Asthma_Homo sapiens_hsa053101.89707547
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89553927
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87275256
27Folate biosynthesis_Homo sapiens_hsa007901.84659697
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83598441
29RNA polymerase_Homo sapiens_hsa030201.82365328
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78866750
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71568351
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67884451
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63119867
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61305114
35Lysosome_Homo sapiens_hsa041421.60043765
36Influenza A_Homo sapiens_hsa051641.56437440
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.55754677
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.55281798
39Type I diabetes mellitus_Homo sapiens_hsa049401.52204612
40RNA transport_Homo sapiens_hsa030131.50912508
41Toxoplasmosis_Homo sapiens_hsa051451.50409968
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48687382
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46703493
44Tryptophan metabolism_Homo sapiens_hsa003801.46317938
45Legionellosis_Homo sapiens_hsa051341.45927844
46Biosynthesis of amino acids_Homo sapiens_hsa012301.44902800
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.43792845
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43286481
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43015677
50Caffeine metabolism_Homo sapiens_hsa002321.42880273
51Hematopoietic cell lineage_Homo sapiens_hsa046401.41576377
52Fatty acid degradation_Homo sapiens_hsa000711.38837437
53Primary immunodeficiency_Homo sapiens_hsa053401.37276319
54Complement and coagulation cascades_Homo sapiens_hsa046101.37078497
55Viral myocarditis_Homo sapiens_hsa054161.34715926
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31910452
57Pentose phosphate pathway_Homo sapiens_hsa000301.29502687
58Arginine biosynthesis_Homo sapiens_hsa002201.28173849
59Cell cycle_Homo sapiens_hsa041101.25828222
60Notch signaling pathway_Homo sapiens_hsa043301.22989240
61Fanconi anemia pathway_Homo sapiens_hsa034601.20609763
62Pertussis_Homo sapiens_hsa051331.19666178
63Shigellosis_Homo sapiens_hsa051311.19658347
64Malaria_Homo sapiens_hsa051441.19381728
65Carbon metabolism_Homo sapiens_hsa012001.18319109
66Chemokine signaling pathway_Homo sapiens_hsa040621.18097841
67TNF signaling pathway_Homo sapiens_hsa046681.18070392
68T cell receptor signaling pathway_Homo sapiens_hsa046601.16779140
69Nitrogen metabolism_Homo sapiens_hsa009101.16392919
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15858979
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15635704
72Rheumatoid arthritis_Homo sapiens_hsa053231.14221440
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13159564
74Phagosome_Homo sapiens_hsa041451.12920391
75Hepatitis B_Homo sapiens_hsa051611.11169222
76Pyruvate metabolism_Homo sapiens_hsa006201.10400372
77Chronic myeloid leukemia_Homo sapiens_hsa052201.08912616
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02717202
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.01966311
80Hepatitis C_Homo sapiens_hsa051601.00578248
81Peroxisome_Homo sapiens_hsa041460.99548836
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99259305
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.97887145
84Salmonella infection_Homo sapiens_hsa051320.97854742
85Vitamin B6 metabolism_Homo sapiens_hsa007500.97583624
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97233348
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96852947
88RNA degradation_Homo sapiens_hsa030180.96614561
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96118799
90Apoptosis_Homo sapiens_hsa042100.95709761
91Purine metabolism_Homo sapiens_hsa002300.94586106
92Non-small cell lung cancer_Homo sapiens_hsa052230.93472684
93Pancreatic cancer_Homo sapiens_hsa052120.90422900
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89207157
95VEGF signaling pathway_Homo sapiens_hsa043700.86305099
96Platelet activation_Homo sapiens_hsa046110.80279721
97Staphylococcus aureus infection_Homo sapiens_hsa051500.79596621
98Herpes simplex infection_Homo sapiens_hsa051680.79125442
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78423981
100Butanoate metabolism_Homo sapiens_hsa006500.74153445
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73612144
102Lysine degradation_Homo sapiens_hsa003100.73112083
103Fructose and mannose metabolism_Homo sapiens_hsa000510.72724542
104Systemic lupus erythematosus_Homo sapiens_hsa053220.71197426
105Basal transcription factors_Homo sapiens_hsa030220.70972656
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70573360
107beta-Alanine metabolism_Homo sapiens_hsa004100.70367493
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.70174731
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69853588
110Bladder cancer_Homo sapiens_hsa052190.69279383
111Histidine metabolism_Homo sapiens_hsa003400.69146628
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67708930
113HTLV-I infection_Homo sapiens_hsa051660.67670738
114African trypanosomiasis_Homo sapiens_hsa051430.66231953
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65845897
116p53 signaling pathway_Homo sapiens_hsa041150.65705328
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65315222
118Non-homologous end-joining_Homo sapiens_hsa034500.65286594
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.65135150
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.62918372
121Tyrosine metabolism_Homo sapiens_hsa003500.62364224
122Antigen processing and presentation_Homo sapiens_hsa046120.62249951
123Arginine and proline metabolism_Homo sapiens_hsa003300.60290767
124Fatty acid metabolism_Homo sapiens_hsa012120.58645785
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58378421
126Propanoate metabolism_Homo sapiens_hsa006400.58018739
127Chemical carcinogenesis_Homo sapiens_hsa052040.57855673
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57800502
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.57432820
130Retinol metabolism_Homo sapiens_hsa008300.56841513
131ABC transporters_Homo sapiens_hsa020100.55542552
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.55263058
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53793832
134Choline metabolism in cancer_Homo sapiens_hsa052310.52722849
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52669896
136Metabolic pathways_Homo sapiens_hsa011000.52515608
137Acute myeloid leukemia_Homo sapiens_hsa052210.51373775
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50647404
139N-Glycan biosynthesis_Homo sapiens_hsa005100.50121794
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48607932
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48556869
142Epstein-Barr virus infection_Homo sapiens_hsa051690.48249467
143mTOR signaling pathway_Homo sapiens_hsa041500.47926562
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47742802
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.46511478
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46467315
147Colorectal cancer_Homo sapiens_hsa052100.45988052
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.45573355
149Glutathione metabolism_Homo sapiens_hsa004800.43680252
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43272415
151Fat digestion and absorption_Homo sapiens_hsa049750.42222380
152Regulation of autophagy_Homo sapiens_hsa041400.42175144
153Measles_Homo sapiens_hsa051620.41935583
154Prolactin signaling pathway_Homo sapiens_hsa049170.41076593
155Endocytosis_Homo sapiens_hsa041440.40132109
156Galactose metabolism_Homo sapiens_hsa000520.39910530
157PPAR signaling pathway_Homo sapiens_hsa033200.38134026
158Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38103965
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37516787
160Sphingolipid metabolism_Homo sapiens_hsa006000.37098980
161Insulin resistance_Homo sapiens_hsa049310.37041058
162Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35997139
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.33889997
164Phenylalanine metabolism_Homo sapiens_hsa003600.32586694
165NF-kappa B signaling pathway_Homo sapiens_hsa040640.32461147
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31749622
167B cell receptor signaling pathway_Homo sapiens_hsa046620.31360230
168Viral carcinogenesis_Homo sapiens_hsa052030.31181975
169Amoebiasis_Homo sapiens_hsa051460.30355212
170Protein export_Homo sapiens_hsa030600.29645651
171Thyroid cancer_Homo sapiens_hsa052160.29003832
172Fatty acid elongation_Homo sapiens_hsa000620.27414765
173mRNA surveillance pathway_Homo sapiens_hsa030150.26545730
174Starch and sucrose metabolism_Homo sapiens_hsa005000.24189493

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