ZBTB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)7.08375882
2cellular ketone body metabolic process (GO:0046950)6.46370368
3negative regulation of neurotransmitter secretion (GO:0046929)6.30296473
4ketone body metabolic process (GO:1902224)5.63897172
5nuclear pore complex assembly (GO:0051292)5.61538384
6nuclear pore organization (GO:0006999)4.96270641
7positive regulation of chromosome segregation (GO:0051984)4.85036649
8regulation of nucleobase-containing compound transport (GO:0032239)4.83986081
9regulation of pigment cell differentiation (GO:0050932)4.50084459
10regulation of DNA endoreduplication (GO:0032875)4.41073978
11Rap protein signal transduction (GO:0032486)4.26899904
12stress granule assembly (GO:0034063)4.24549883
13neuron remodeling (GO:0016322)4.23675045
14phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.16369289
15non-recombinational repair (GO:0000726)4.08152872
16double-strand break repair via nonhomologous end joining (GO:0006303)4.08152872
17cellular protein complex localization (GO:0034629)4.00863849
18negative regulation of neurotransmitter transport (GO:0051589)3.93684019
19regulation of centriole replication (GO:0046599)3.92110604
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86146498
21regulation of DNA damage checkpoint (GO:2000001)3.85004997
22intestinal epithelial cell development (GO:0060576)3.78387428
23mitotic chromosome condensation (GO:0007076)3.78356905
24pore complex assembly (GO:0046931)3.77864740
25purine nucleobase biosynthetic process (GO:0009113)3.76134701
26nerve growth factor signaling pathway (GO:0038180)3.69479376
27response to UV-C (GO:0010225)3.61768549
28N-terminal protein amino acid acetylation (GO:0006474)3.60884173
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53257533
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.53257533
31modulation by symbiont of host immune response (GO:0052553)3.53257533
32positive regulation by symbiont of host defense response (GO:0052509)3.53257533
33modulation by symbiont of host defense response (GO:0052031)3.53257533
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53257533
35histone H3-K36 demethylation (GO:0070544)3.46630401
36establishment of integrated proviral latency (GO:0075713)3.46537290
37IMP biosynthetic process (GO:0006188)3.44864972
38negative regulation of translational initiation (GO:0045947)3.40150052
39maternal behavior (GO:0042711)3.38035440
40mitotic metaphase plate congression (GO:0007080)3.37922610
41homocysteine metabolic process (GO:0050667)3.35456353
42detection of other organism (GO:0098543)3.33411838
43formation of translation preinitiation complex (GO:0001731)3.29081339
44negative regulation of T-helper cell differentiation (GO:0045623)3.24782581
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24782581
46neural tube formation (GO:0001841)3.22955106
47negative regulation of keratinocyte proliferation (GO:0010839)3.22465237
48negative regulation of circadian rhythm (GO:0042754)3.21192619
49parental behavior (GO:0060746)3.19137381
50interferon-gamma production (GO:0032609)3.18984355
51I-kappaB phosphorylation (GO:0007252)3.17436863
52IMP metabolic process (GO:0046040)3.16506433
53protein complex localization (GO:0031503)3.13543078
54telomere maintenance via recombination (GO:0000722)3.08322265
55facial nerve structural organization (GO:0021612)3.07891335
56mitotic G2 DNA damage checkpoint (GO:0007095)3.06379438
57mitotic recombination (GO:0006312)3.01672230
58positive regulation of gamma-delta T cell activation (GO:0046645)2.99328383
59embryonic camera-type eye morphogenesis (GO:0048596)2.98253586
60negative regulation of granulocyte differentiation (GO:0030853)2.97109737
61CENP-A containing nucleosome assembly (GO:0034080)2.96429997
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.96046717
63response to host immune response (GO:0052572)2.94358234
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94358234
65establishment of chromosome localization (GO:0051303)2.93956122
66regulation of B cell receptor signaling pathway (GO:0050855)2.92777468
67detection of bacterium (GO:0016045)2.90831988
68metaphase plate congression (GO:0051310)2.89926851
69negative regulation of exocytosis (GO:0045920)2.89199339
70labyrinthine layer development (GO:0060711)2.86621395
71kidney mesenchyme development (GO:0072074)2.86165282
72positive regulation of mitotic cell cycle phase transition (GO:1901992)2.86135759
73chromatin remodeling at centromere (GO:0031055)2.81733374
74positive regulation of cell size (GO:0045793)2.80662867
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79834943
76regulation of chromatin silencing (GO:0031935)2.79401987
77replicative senescence (GO:0090399)2.78458345
78response to gamma radiation (GO:0010332)2.76648656
79regulation of T-helper 2 cell differentiation (GO:0045628)2.75877649
80DNA unwinding involved in DNA replication (GO:0006268)2.75515737
81regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74835039
82protein localization to chromosome, centromeric region (GO:0071459)2.74815485
83negative regulation of interleukin-17 production (GO:0032700)2.73656720
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73653076
85mitotic G2/M transition checkpoint (GO:0044818)2.69724394
86positive regulation of cell cycle phase transition (GO:1901989)2.69210696
87nucleobase biosynthetic process (GO:0046112)2.68965833
88ganglion development (GO:0061548)2.68710291
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68279743
90localization within membrane (GO:0051668)2.65957581
91nucleotide-excision repair, DNA gap filling (GO:0006297)2.65362896
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.63601876
93regulation of translation, ncRNA-mediated (GO:0045974)2.63601876
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63601876
95cytoplasmic mRNA processing body assembly (GO:0033962)2.63488953
96determination of adult lifespan (GO:0008340)2.62507964
97metanephric mesenchyme development (GO:0072075)2.61304546
98negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.60955975
99B cell homeostasis (GO:0001782)2.60523838
100detection of molecule of bacterial origin (GO:0032490)2.60191086
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59628568
102response to host (GO:0075136)2.59628568
103response to host defenses (GO:0052200)2.59628568
104photoreceptor cell maintenance (GO:0045494)2.59208019
105response to xenobiotic stimulus (GO:0009410)2.57898164
106definitive hemopoiesis (GO:0060216)2.56630797
107negative regulation of peptidyl-lysine acetylation (GO:2000757)2.56202336
108forebrain neuron development (GO:0021884)2.55087107
109regulation of T-helper 1 cell differentiation (GO:0045625)2.53785266
110glutamine metabolic process (GO:0006541)2.53761158
111positive regulation of T cell cytokine production (GO:0002726)2.53638872
112sister chromatid cohesion (GO:0007062)2.53621281
113positive regulation of vasculogenesis (GO:2001214)2.53401763
114embryonic process involved in female pregnancy (GO:0060136)2.53352393
115negative regulation of mast cell activation (GO:0033004)2.53048527
116telomere maintenance via telomerase (GO:0007004)2.52290192
117forebrain morphogenesis (GO:0048853)2.52104627
118dentate gyrus development (GO:0021542)2.51473194
119regulation of centrosome duplication (GO:0010824)2.51110972
120cranial nerve structural organization (GO:0021604)2.51093012
121lateral ventricle development (GO:0021670)2.50632138
122radial glial cell differentiation (GO:0060019)2.47903419
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47609066
124eyelid development in camera-type eye (GO:0061029)2.47567077
125peptidyl-lysine trimethylation (GO:0018023)2.47270431
126mesenchymal cell differentiation involved in renal system development (GO:2001012)2.46655312
127mesenchymal cell differentiation involved in kidney development (GO:0072161)2.46655312
128CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46456384
129T-helper cell differentiation (GO:0042093)2.46456384
130histone ubiquitination (GO:0016574)2.45188149
131anatomical structure arrangement (GO:0048532)2.43207268
132regulation of centrosome cycle (GO:0046605)2.42994278
133negative regulation of histone acetylation (GO:0035067)2.42883439
134regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42791844
135negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41583181
136positive regulation of cellular amide metabolic process (GO:0034250)2.40305090
137regulation of keratinocyte differentiation (GO:0045616)2.40053976
138microtubule depolymerization (GO:0007019)2.39120211
139mitotic sister chromatid cohesion (GO:0007064)2.38917941
140protein localization to microtubule (GO:0035372)2.38697344
141negative regulation of viral genome replication (GO:0045071)2.38322652
142microtubule nucleation (GO:0007020)2.38194829
143establishment of viral latency (GO:0019043)2.38186682
144monoubiquitinated protein deubiquitination (GO:0035520)2.37714182
145CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.37610631
146peptidyl-threonine dephosphorylation (GO:0035970)2.37291253
147retinal cone cell development (GO:0046549)2.33444769
148response to peptidoglycan (GO:0032494)2.30796738
149superoxide anion generation (GO:0042554)2.30737929
150postsynaptic membrane organization (GO:0001941)2.28795017
151detection of external biotic stimulus (GO:0098581)2.28730888
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.26587263
153embryonic eye morphogenesis (GO:0048048)2.25785830
154positive regulation of antigen processing and presentation (GO:0002579)2.24989868
155pericardium development (GO:0060039)2.24078292
156central nervous system projection neuron axonogenesis (GO:0021952)2.22510585
157mature B cell differentiation (GO:0002335)2.22293183
158histone demethylation (GO:0016577)2.22284303
159cyclic nucleotide catabolic process (GO:0009214)2.21646030
160macrophage activation involved in immune response (GO:0002281)2.19904286
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.18800632
162axoneme assembly (GO:0035082)2.18579027
163positive regulation of mitotic sister chromatid separation (GO:1901970)2.18336327
164positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.18336327
165positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.18336327
166histone lysine demethylation (GO:0070076)2.17236594
167regulation of fibroblast apoptotic process (GO:2000269)2.17154498
168response to X-ray (GO:0010165)2.15982051
169interkinetic nuclear migration (GO:0022027)2.14881055
170photoreceptor cell differentiation (GO:0046530)2.14871509
171eye photoreceptor cell differentiation (GO:0001754)2.14871509
172histone H2A monoubiquitination (GO:0035518)2.14523618
173olfactory bulb development (GO:0021772)2.14429196
174eye photoreceptor cell development (GO:0042462)2.13703059
175regulation of hexokinase activity (GO:1903299)2.12982461
176regulation of glucokinase activity (GO:0033131)2.12982461
177CD4-positive, alpha-beta T cell activation (GO:0035710)2.12237808
178regulation of RNA export from nucleus (GO:0046831)2.12036564
179centrosome duplication (GO:0051298)2.11905619
180inflammatory response to antigenic stimulus (GO:0002437)2.11832098
181germ cell migration (GO:0008354)2.11805762
182pyrimidine dimer repair (GO:0006290)2.11528912
183cell differentiation involved in metanephros development (GO:0072202)2.10551814
184dendritic cell migration (GO:0036336)2.10380084
185regulation of rhodopsin mediated signaling pathway (GO:0022400)2.09957348
186mesenchymal cell differentiation (GO:0048762)2.09748797
187B cell proliferation (GO:0042100)2.09020003
188rhodopsin mediated signaling pathway (GO:0016056)2.08984091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34703459
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51995293
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.38649027
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.29673707
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21533007
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.19670431
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17107751
8GBX2_23144817_ChIP-Seq_PC3_Human2.96929928
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.87946761
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81742359
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71625639
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.63570356
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52669069
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.44990673
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.42102311
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34133654
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.29247735
18AR_21909140_ChIP-Seq_LNCAP_Human2.26463511
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.24876107
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23639959
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23603204
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22014995
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.20744056
24PKCTHETA_26484144_Chip-Seq_BREAST_Human2.13581450
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93736108
26EWS_26573619_Chip-Seq_HEK293_Human1.92788633
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91985497
28* NOTCH1_21737748_ChIP-Seq_TLL_Human1.91815077
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90752236
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89803671
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88619800
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88260241
33IGF1R_20145208_ChIP-Seq_DFB_Human1.85799833
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84868827
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.84266754
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.83691658
37P300_19829295_ChIP-Seq_ESCs_Human1.81781464
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79618763
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.78750342
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77747878
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76801398
42ER_23166858_ChIP-Seq_MCF-7_Human1.76366807
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76316706
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75627665
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74802002
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74597948
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72608584
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.69576885
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.68828422
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65962715
51FUS_26573619_Chip-Seq_HEK293_Human1.65454423
52* TP63_19390658_ChIP-ChIP_HaCaT_Human1.65397277
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.63290047
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62728730
55P53_22387025_ChIP-Seq_ESCs_Mouse1.61628341
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58580379
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56139079
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54304083
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50474432
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.50342594
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49703399
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.47365129
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47102731
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.46237927
65* ELK1_19687146_ChIP-ChIP_HELA_Human1.45979031
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45751418
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44307347
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43825471
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42954835
70TP53_18474530_ChIP-ChIP_U2OS_Human1.42362063
71SMAD4_21799915_ChIP-Seq_A2780_Human1.41564738
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41318112
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40761530
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.38488722
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36578974
76TAF15_26573619_Chip-Seq_HEK293_Human1.34261597
77STAT3_23295773_ChIP-Seq_U87_Human1.33796549
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33009740
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32752861
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32607894
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32516230
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.32461240
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32409639
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31699766
85P300_18555785_Chip-Seq_ESCs_Mouse1.31339718
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30336825
87PU1_27457419_Chip-Seq_LIVER_Mouse1.30329676
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29211605
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.28183511
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27981335
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27685169
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27617512
93RNF2_27304074_Chip-Seq_NSC_Mouse1.27129378
94E2F7_22180533_ChIP-Seq_HELA_Human1.25981782
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25548647
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24700107
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.23855976
98CHD1_26751641_Chip-Seq_LNCaP_Human1.23259513
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23078591
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23006221
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22284171
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.22064340
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.22009396
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21344219
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19953940
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.19166048
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18584438
108* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18140935
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.18040502
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.17837236
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16988929
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.15479592
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14654593
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13973909
115AR_25329375_ChIP-Seq_VCAP_Human1.13470863
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13230373
117TCF4_23295773_ChIP-Seq_U87_Human1.13148667
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12914986
119* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12650727
120* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12650727
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12391433
122IRF8_21731497_ChIP-ChIP_J774_Mouse1.11846323
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11585569
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11491622
125MYC_18555785_ChIP-Seq_MESCs_Mouse1.10629087
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10468326
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09633286
128SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08997692
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.08277457
130SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07886545
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.07629078
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06672060
133RUNX2_22187159_ChIP-Seq_PCA_Human1.05998007
134RUNX_20019798_ChIP-Seq_JUKART_Human1.04809725
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04226594
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04204004
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02335538
138KDM2B_26808549_Chip-Seq_REH_Human1.00901364
139FOXO3_23340844_ChIP-Seq_DLD1_Human1.00510289
140SMAD3_21741376_ChIP-Seq_EPCs_Human1.00421515
141AHR_22903824_ChIP-Seq_MCF-7_Human1.00253449
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00221280
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99787304
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99194465
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97494285
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97055600
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97055600
148TP63_17297297_ChIP-ChIP_HaCaT_Human0.96800767
149REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96665618
150TFEB_21752829_ChIP-Seq_HELA_Human0.92543595
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90930349
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90602470
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89306084
154PU_27001747_Chip-Seq_BMDM_Mouse0.86850966
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86515330
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84848172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.46289322
2MP0000569_abnormal_digit_pigmentation4.94117392
3MP0008057_abnormal_DNA_replication4.03813132
4MP0001188_hyperpigmentation3.34247279
5MP0000015_abnormal_ear_pigmentation2.74121885
6MP0002009_preneoplasia2.64417986
7MP0010352_gastrointestinal_tract_polyps2.62519834
8MP0003787_abnormal_imprinting2.38538896
9MP0010234_abnormal_vibrissa_follicle2.37668647
10MP0003221_abnormal_cardiomyocyte_apopto2.36230161
11MP0005248_abnormal_Harderian_gland2.21176144
12MP0003724_increased_susceptibility_to2.19457780
13MP0008260_abnormal_autophagy2.12937882
14MP0001835_abnormal_antigen_presentation2.03536944
15MP0005171_absent_coat_pigmentation2.03055373
16MP0001346_abnormal_lacrimal_gland1.94251963
17MP0003077_abnormal_cell_cycle1.90200018
18MP0005174_abnormal_tail_pigmentation1.82668641
19MP0005187_abnormal_penis_morphology1.82429732
20MP0002638_abnormal_pupillary_reflex1.82376438
21MP0002102_abnormal_ear_morphology1.80052907
22MP0002006_tumorigenesis1.76779076
23MP0003183_abnormal_peptide_metabolism1.74467153
24MP0008007_abnormal_cellular_replicative1.73017474
25MP0008058_abnormal_DNA_repair1.71772030
26MP0002166_altered_tumor_susceptibility1.62177604
27MP0000516_abnormal_urinary_system1.59468725
28MP0005367_renal/urinary_system_phenotyp1.59468725
29MP0002277_abnormal_respiratory_mucosa1.57150237
30MP0002095_abnormal_skin_pigmentation1.52612795
31MP0000372_irregular_coat_pigmentation1.51691577
32MP0006292_abnormal_olfactory_placode1.50912727
33MP0001986_abnormal_taste_sensitivity1.49460042
34MP0003693_abnormal_embryo_hatching1.47204530
35MP0004957_abnormal_blastocyst_morpholog1.46507243
36MP0005645_abnormal_hypothalamus_physiol1.46237537
37MP0005451_abnormal_body_composition1.43469071
38MP0006072_abnormal_retinal_apoptosis1.43032610
39MP0003763_abnormal_thymus_physiology1.42380989
40MP0003828_pulmonary_edema1.42230842
41MP0003315_abnormal_perineum_morphology1.38271391
42MP0002452_abnormal_antigen_presenting1.37473337
43MP0005671_abnormal_response_to1.36866024
44MP0005551_abnormal_eye_electrophysiolog1.34890688
45MP0002877_abnormal_melanocyte_morpholog1.34059119
46MP0009785_altered_susceptibility_to1.33613753
47MP0005501_abnormal_skin_physiology1.33300454
48MP0005387_immune_system_phenotype1.32977688
49MP0001790_abnormal_immune_system1.32977688
50MP0004264_abnormal_extraembryonic_tissu1.32171549
51MP0001800_abnormal_humoral_immune1.28884894
52MP0000490_abnormal_crypts_of1.26280318
53MP0005253_abnormal_eye_physiology1.24407346
54MP0005409_darkened_coat_color1.20904338
55MP0002419_abnormal_innate_immunity1.20700493
56MP0002876_abnormal_thyroid_physiology1.20583834
57MP0003943_abnormal_hepatobiliary_system1.20117001
58MP0003656_abnormal_erythrocyte_physiolo1.19280007
59MP0002796_impaired_skin_barrier1.19182857
60MP0000627_abnormal_mammary_gland1.19127937
61MP0003937_abnormal_limbs/digits/tail_de1.18091034
62MP0003890_abnormal_embryonic-extraembry1.18049242
63MP0003705_abnormal_hypodermis_morpholog1.17630555
64MP0005000_abnormal_immune_tolerance1.15401948
65MP0002396_abnormal_hematopoietic_system1.15116468
66MP0003941_abnormal_skin_development1.13995521
67MP0000537_abnormal_urethra_morphology1.13817026
68MP0001819_abnormal_immune_cell1.13779734
69MP0001764_abnormal_homeostasis1.13542923
70MP0002420_abnormal_adaptive_immunity1.12824147
71MP0001191_abnormal_skin_condition1.11524092
72MP0009697_abnormal_copulation1.10421670
73MP0002723_abnormal_immune_serum1.10310342
74MP0002177_abnormal_outer_ear1.09349196
75MP0003300_gastrointestinal_ulcer1.09029196
76MP0003136_yellow_coat_color1.08874589
77MP0001672_abnormal_embryogenesis/_devel1.08809592
78MP0005380_embryogenesis_phenotype1.08809592
79MP0004808_abnormal_hematopoietic_stem1.08533732
80MP0009250_abnormal_appendicular_skeleto1.07467244
81MP0000350_abnormal_cell_proliferation1.06422947
82MP0010094_abnormal_chromosome_stability1.05420869
83MP0003121_genomic_imprinting1.04317206
84MP0000681_abnormal_thyroid_gland1.03985234
85MP0000465_gastrointestinal_hemorrhage1.03724806
86MP0000703_abnormal_thymus_morphology1.03682276
87MP0003984_embryonic_growth_retardation1.03576146
88MP0010307_abnormal_tumor_latency1.03407267
89MP0001919_abnormal_reproductive_system1.03065253
90MP0000427_abnormal_hair_cycle1.02874579
91MP0009764_decreased_sensitivity_to1.02237644
92MP0005391_vision/eye_phenotype1.01811964
93MP0004233_abnormal_muscle_weight1.00792695
94MP0001186_pigmentation_phenotype1.00271610
95MP0000383_abnormal_hair_follicle0.99284718
96MP0002088_abnormal_embryonic_growth/wei0.99225009
97MP0004043_abnormal_pH_regulation0.98380699
98MP0001293_anophthalmia0.98109571
99MP0002398_abnormal_bone_marrow0.97676919
100MP0002148_abnormal_hypersensitivity_rea0.96770255
101MP0002163_abnormal_gland_morphology0.96603231
102MP0001348_abnormal_lacrimal_gland0.95638789
103MP0001286_abnormal_eye_development0.94526651
104MP0000371_diluted_coat_color0.94108134
105MP0002132_abnormal_respiratory_system0.92236205
106MP0002998_abnormal_bone_remodeling0.90487422
107MP0004484_altered_response_of0.90053980
108MP0005076_abnormal_cell_differentiation0.89935576
109MP0002928_abnormal_bile_duct0.86929588
110MP0002086_abnormal_extraembryonic_tissu0.86847684
111MP0005257_abnormal_intraocular_pressure0.86758015
112MP0001324_abnormal_eye_pigmentation0.85986396
113MP0003935_abnormal_craniofacial_develop0.84726358
114MP0002092_abnormal_eye_morphology0.84615520
115MP0001697_abnormal_embryo_size0.83615135
116MP0000428_abnormal_craniofacial_morphol0.83366894
117MP0000432_abnormal_head_morphology0.82962772
118MP0004197_abnormal_fetal_growth/weight/0.82631132
119MP0002075_abnormal_coat/hair_pigmentati0.82483215
120MP0010155_abnormal_intestine_physiology0.82447120
121MP0003453_abnormal_keratinocyte_physiol0.82156694
122MP0003385_abnormal_body_wall0.82030424
123MP0001873_stomach_inflammation0.81433987
124MP0005025_abnormal_response_to0.80949006
125MP0004134_abnormal_chest_morphology0.80653190
126MP0005389_reproductive_system_phenotype0.79468100
127MP0003011_delayed_dark_adaptation0.79227115
128MP0001340_abnormal_eyelid_morphology0.79104342
129MP0001216_abnormal_epidermal_layer0.78931744
130MP0002697_abnormal_eye_size0.78805216
131MP0008789_abnormal_olfactory_epithelium0.78771216
132MP0002896_abnormal_bone_mineralization0.78654033
133MP0001299_abnormal_eye_distance/0.78420696
134MP0001119_abnormal_female_reproductive0.78403498
135MP0004185_abnormal_adipocyte_glucose0.78309986
136MP0000716_abnormal_immune_system0.78303386
137MP0005195_abnormal_posterior_eye0.78239479
138MP0000778_abnormal_nervous_system0.77963261
139MP0000631_abnormal_neuroendocrine_gland0.77745337
140MP0002109_abnormal_limb_morphology0.77092637
141MP0003111_abnormal_nucleus_morphology0.76398749
142MP0008877_abnormal_DNA_methylation0.76239726
143MP0002080_prenatal_lethality0.74273566
144MP0003091_abnormal_cell_migration0.73415256
145MP0003567_abnormal_fetal_cardiomyocyte0.71918903
146MP0001730_embryonic_growth_arrest0.69315010
147MP0003119_abnormal_digestive_system0.69138824
148MP0000858_altered_metastatic_potential0.69052041
149MP0001851_eye_inflammation0.68807881
150MP0010678_abnormal_skin_adnexa0.68603951
151MP0003448_altered_tumor_morphology0.66494835
152MP0002722_abnormal_immune_system0.66424841
153MP0002234_abnormal_pharynx_morphology0.66057529
154MP0009053_abnormal_anal_canal0.65669797
155MP0003936_abnormal_reproductive_system0.64979802
156MP0000613_abnormal_salivary_gland0.64882055
157MP0002085_abnormal_embryonic_tissue0.62748406
158MP0000733_abnormal_muscle_development0.62632868
159MP0005197_abnormal_uvea_morphology0.61323914
160MP0005623_abnormal_meninges_morphology0.58667198
161MP0008770_decreased_survivor_rate0.58571054
162MP0008961_abnormal_basal_metabolism0.57993938
163MP0005621_abnormal_cell_physiology0.55627714
164MP0001529_abnormal_vocalization0.55580647

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)4.00365073
2Ketoacidosis (HP:0001993)3.75372896
3Facial hemangioma (HP:0000329)3.72901540
4Congenital stationary night blindness (HP:0007642)3.63399109
5Curly hair (HP:0002212)3.46865524
6Buphthalmos (HP:0000557)3.37554411
7Missing ribs (HP:0000921)3.32085689
8Cystic hygroma (HP:0000476)3.23410410
9Methylmalonic acidemia (HP:0002912)3.22030884
10Prostate neoplasm (HP:0100787)3.18491545
11Abnormality of the nasal septum (HP:0000419)3.17421703
12Choroideremia (HP:0001139)3.16589925
13Retrobulbar optic neuritis (HP:0100654)3.03428469
14Optic neuritis (HP:0100653)3.03428469
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96966868
16Conjunctival telangiectasia (HP:0000524)2.85440955
17Bony spicule pigmentary retinopathy (HP:0007737)2.82870233
18Transitional cell carcinoma of the bladder (HP:0006740)2.82394317
19Abnormality of the prostate (HP:0008775)2.80143858
20Chromsome breakage (HP:0040012)2.78887990
21Prominent metopic ridge (HP:0005487)2.77300310
22Abnormality of the vitamin B12 metabolism (HP:0004341)2.73276227
23Postnatal microcephaly (HP:0005484)2.71734010
24Bladder carcinoma (HP:0002862)2.68277179
25Bladder neoplasm (HP:0009725)2.68277179
26Metaphyseal cupping (HP:0003021)2.61236141
27Thoracolumbar scoliosis (HP:0002944)2.59297936
28Submucous cleft hard palate (HP:0000176)2.58295099
29Aplasia/Hypoplasia of the thymus (HP:0010515)2.56329926
30Abnormality of the thymus (HP:0000777)2.51260683
31Thickened calvaria (HP:0002684)2.51064671
32Abnormality of the metopic suture (HP:0005556)2.50428480
33Sparse lateral eyebrow (HP:0005338)2.47947291
34Skin nodule (HP:0200036)2.47885912
35Abnormality of the fingertips (HP:0001211)2.47561893
36Absent frontal sinuses (HP:0002688)2.46153729
37Syringomyelia (HP:0003396)2.45126011
38Spinal cord lesions (HP:0100561)2.45126011
39Abnormality of vitamin B metabolism (HP:0004340)2.41643326
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41241392
41Complete atrioventricular canal defect (HP:0001674)2.38818714
42Chronic hepatic failure (HP:0100626)2.38661751
43Poikiloderma (HP:0001029)2.34751410
44Leiomyosarcoma (HP:0100243)2.34518095
45Uterine leiomyosarcoma (HP:0002891)2.34518095
46Abnormality of the left ventricular outflow tract (HP:0011103)2.34343742
47Subaortic stenosis (HP:0001682)2.34343742
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.30622896
49Megaloblastic anemia (HP:0001889)2.28461953
50Lymphedema (HP:0001004)2.27408248
51Thyroid carcinoma (HP:0002890)2.27158380
52Mesomelia (HP:0003027)2.25986148
53Fibrous tissue neoplasm (HP:0012316)2.25497541
54Entropion (HP:0000621)2.24615652
55Relative macrocephaly (HP:0004482)2.24386364
56Orchitis (HP:0100796)2.24075795
57Mediastinal lymphadenopathy (HP:0100721)2.21545463
5811 pairs of ribs (HP:0000878)2.21329759
59Papillary thyroid carcinoma (HP:0002895)2.21289473
60Ankyloglossia (HP:0010296)2.21195639
61Fibroma (HP:0010614)2.18796060
62Insidious onset (HP:0003587)2.18438364
63Termporal pattern (HP:0011008)2.18438364
64Protruding tongue (HP:0010808)2.15704267
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.13392665
66Abnormality of chromosome stability (HP:0003220)2.12521227
67Midline defect of the nose (HP:0004122)2.12103543
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.10838688
69Decreased central vision (HP:0007663)2.10206410
70Dry hair (HP:0011359)2.09683945
71Hypoplastic iliac wings (HP:0002866)2.07944399
72Abnormal rod and cone electroretinograms (HP:0008323)2.07444690
73Attenuation of retinal blood vessels (HP:0007843)2.06987649
74Tubulointerstitial nephritis (HP:0001970)2.05044715
75Abnormal hair whorl (HP:0010721)2.04413057
76Recurrent cutaneous fungal infections (HP:0011370)2.01129480
77Chronic mucocutaneous candidiasis (HP:0002728)2.01129480
78Arterial thrombosis (HP:0004420)2.00718037
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00659898
80Abnormality of the parietal bone (HP:0002696)1.98877946
81Heterotopia (HP:0002282)1.98376541
82Asymmetry of the thorax (HP:0001555)1.97878555
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96777638
84Short 4th metacarpal (HP:0010044)1.96777638
85Recurrent fungal infections (HP:0002841)1.96327058
86Low anterior hairline (HP:0000294)1.95985790
87Neuroendocrine neoplasm (HP:0100634)1.95328596
88Myositis (HP:0100614)1.94882793
89Sandal gap (HP:0001852)1.94392759
90Severe combined immunodeficiency (HP:0004430)1.94323461
91Abnormality of oral frenula (HP:0000190)1.94083573
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93429816
93Capillary hemangiomas (HP:0005306)1.92928083
94Flat acetabular roof (HP:0003180)1.92665055
95Meningitis (HP:0001287)1.92105856
96Abnormal auditory evoked potentials (HP:0006958)1.91315150
97Chorioretinal atrophy (HP:0000533)1.90820716
98Neoplasm of the adrenal cortex (HP:0100641)1.90639166
99Ectopic kidney (HP:0000086)1.90429807
100Generalized hypopigmentation of hair (HP:0011358)1.89874053
101Combined immunodeficiency (HP:0005387)1.89560248
102Glomerulopathy (HP:0100820)1.88880873
103Abnormal foot bone ossification (HP:0010675)1.88620574
104Chronic obstructive pulmonary disease (HP:0006510)1.88603819
105Obstructive lung disease (HP:0006536)1.88603819
106Osteomalacia (HP:0002749)1.88474994
107Gastrointestinal carcinoma (HP:0002672)1.88163459
108Malignant gastrointestinal tract tumors (HP:0006749)1.88163459
109Chronic diarrhea (HP:0002028)1.87962653
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87835986
111Lip pit (HP:0100267)1.87566723
112Osteolytic defects of the hand bones (HP:0009699)1.86448269
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.86448269
114Cubitus valgus (HP:0002967)1.85448196
115Exercise-induced muscle cramps (HP:0003710)1.85336888
116Fair hair (HP:0002286)1.84997736
117Eczematoid dermatitis (HP:0000976)1.84508326
118Vasculitis (HP:0002633)1.84443077
119Deep philtrum (HP:0002002)1.84378308
120Congenital glaucoma (HP:0001087)1.83180732
121Pheochromocytoma (HP:0002666)1.81971992
122Mucosal telangiectasiae (HP:0100579)1.81873932
123Abnormality of DNA repair (HP:0003254)1.81755463
124Abnormality of the phalanges of the hallux (HP:0010057)1.81327386
125Pulmonary infiltrates (HP:0002113)1.79658776
126Atrioventricular canal defect (HP:0006695)1.79601340
127Medulloblastoma (HP:0002885)1.78693270
128Recurrent viral infections (HP:0004429)1.78180206
129Increased corneal curvature (HP:0100692)1.78006530
130Keratoconus (HP:0000563)1.78006530
131Congenital sensorineural hearing impairment (HP:0008527)1.77195254
132Ketosis (HP:0001946)1.75726859
133Abnormality of homocysteine metabolism (HP:0010919)1.74725069
134Homocystinuria (HP:0002156)1.74725069
135Febrile seizures (HP:0002373)1.73772584
136Arteriovenous malformation (HP:0100026)1.73744810
137Acute myeloid leukemia (HP:0004808)1.73563347
138Agammaglobulinemia (HP:0004432)1.72888452
139Hypoplastic ilia (HP:0000946)1.71442110
140Thyroiditis (HP:0100646)1.71360218
141Ureteral obstruction (HP:0006000)1.71283617
142Volvulus (HP:0002580)1.70859649
143Meckel diverticulum (HP:0002245)1.70303795
144Abnormality of vitamin metabolism (HP:0100508)1.70214969
145Recurrent abscess formation (HP:0002722)1.70178769
146Hamartoma (HP:0010566)1.69994475
147Clubbing of toes (HP:0100760)1.68874941
148Arterial tortuosity (HP:0005116)1.68536065
149Absent speech (HP:0001344)1.68449717
150Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68341276
151Abnormal lung lobation (HP:0002101)1.67673788
152Teleangiectasia of the skin (HP:0100585)1.66273471
153Dyschromatopsia (HP:0007641)1.65677035
154Thick nail (HP:0001805)1.65606249
155Abnormality of the frontal sinuses (HP:0002687)1.64662744
156Subacute progressive viral hepatitis (HP:0006572)1.64520834
157Abnormality of the preputium (HP:0100587)1.63511667
158Inappropriate behavior (HP:0000719)1.62504325
159Gastrointestinal infarctions (HP:0005244)1.61867249
160Macroorchidism (HP:0000053)1.61596025
161Long clavicles (HP:0000890)1.60539511
162Hypothermia (HP:0002045)1.59258128
163Vitreoretinal degeneration (HP:0000655)1.58427345
164Increased number of teeth (HP:0011069)1.57545349
165Photophobia (HP:0000613)1.57471151
166Abnormality of the carotid arteries (HP:0005344)1.57412476
167True hermaphroditism (HP:0010459)1.57063076
168Cheilitis (HP:0100825)1.56836306
169Cutaneous melanoma (HP:0012056)1.55827086
170Upper limb muscle weakness (HP:0003484)1.54681514
171Neoplasm of the tracheobronchial system (HP:0100552)1.53935190
172Pendular nystagmus (HP:0012043)1.53779634
173Abnormality of the ileum (HP:0001549)1.53336112
174Hypoplastic labia majora (HP:0000059)1.53323858
175Premature graying of hair (HP:0002216)1.51581483
176Abnormality of male internal genitalia (HP:0000022)1.51555711
177Ureteral stenosis (HP:0000071)1.51321275
178Blue irides (HP:0000635)1.51315937
179Encephalitis (HP:0002383)1.50345507
180Short middle phalanx of the 5th finger (HP:0004220)1.48664423
181Alveolar cell carcinoma (HP:0006519)1.47034694
182Autoimmune thrombocytopenia (HP:0001973)1.44556832
183Smooth philtrum (HP:0000319)1.44526455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.16852895
2TAF13.15710973
3TAOK13.02282114
4ZAK2.77300308
5SRPK12.68352577
6MAP3K142.58823716
7MKNK22.53841008
8ERBB32.53687748
9SCYL22.42841055
10TXK2.42354348
11EIF2AK22.26243594
12FRK2.20879589
13VRK22.16148327
14YES12.13258671
15MARK12.07349002
16TNIK2.06759698
17EPHA32.02968887
18FGFR31.92877618
19EEF2K1.88632583
20IRAK31.86426408
21MKNK11.80960313
22CDC71.64761042
23TLK11.61318338
24MAP3K61.57713007
25RPS6KB21.53211624
26INSRR1.52048209
27IRAK41.49415072
28NLK1.47837307
29CAMK1D1.46131731
30CCNB11.35928638
31PRPF4B1.32501435
32NUAK11.31104686
33FGFR21.30238409
34DYRK31.30013227
35MAP3K101.27374339
36ALK1.25869505
37MAP2K71.20297482
38JAK11.20131110
39BRD41.19213264
40SGK21.18146250
41LATS21.17700004
42TEC1.17181063
43BCR1.14704297
44STK31.14426925
45SMG11.14106197
46TAOK31.10544941
47TAOK21.09825337
48WEE11.07633243
49STK241.06906880
50EIF2AK31.03444074
51CDK31.02938715
52IRAK11.02673667
53LATS11.02204316
54CHUK0.98998886
55ERBB40.98699652
56AKT30.97640491
57KSR10.96957843
58MAPK130.96879945
59MAP3K20.94986997
60CDK70.92523366
61IKBKE0.92485401
62IKBKB0.92465267
63PBK0.92157909
64JAK30.91866155
65MAP3K90.91585020
66VRK10.88592302
67TRIM280.86949131
68PKN10.86227315
69PDGFRA0.84704537
70PLK30.84306797
71GRK10.83031644
72MAP2K30.82902354
73PNCK0.81512880
74PIM10.80950756
75MAP3K50.80641467
76BMPR1B0.79883826
77FGFR40.79670166
78FER0.78751490
79CAMKK20.78431536
80SGK30.78305037
81RPS6KB10.77630205
82PLK20.77439862
83MST1R0.76962351
84NEK60.76830888
85IRAK20.75844022
86MAP4K10.75588960
87TGFBR20.74911924
88MAP2K40.74883067
89NEK90.74296050
90BRSK20.72386061
91SIK30.72218645
92PIK3CA0.71947871
93CAMK40.70823174
94TGFBR10.70577994
95BRAF0.68286845
96AKT20.67836292
97ITK0.67442972
98NTRK20.65906057
99TTK0.65242195
100STK110.64887268
101CDK60.63686572
102CSF1R0.63514076
103CAMK1G0.60862148
104ATR0.59863613
105BLK0.59081448
106CLK10.56855066
107MAP3K10.55666118
108TNK20.55057124
109CDK120.54553828
110TRPM70.54549222
111CHEK20.53812772
112ATM0.52960391
113PKN20.52411611
114HCK0.51619737
115MUSK0.51462705
116GRK70.51356296
117MAPKAPK50.50020019
118SGK10.50009857
119MARK30.49903512
120RPS6KA50.49281600
121PLK40.48950135
122LYN0.48020695
123RET0.46778033
124JAK20.46489211
125SGK4940.45825860
126SGK2230.45825860
127FES0.45660573
128CDK90.45023124
129MAP3K30.44145263
130OBSCN0.43525889
131RIPK40.43440829
132RPS6KC10.43181095
133RPS6KL10.43181095
134PASK0.42714873
135PRKCH0.42381794
136ACVR1B0.41910904
137CSNK1E0.41770249
138TSSK60.41742615
139CSNK1G10.41708208
140HIPK20.41394370
141PDGFRB0.40070721
142CSNK1A1L0.38992308
143DYRK20.38887366
144STK40.36537105
145PRKCE0.35977804
146SYK0.35850487

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.49293793
2Nucleotide excision repair_Homo sapiens_hsa034202.59771368
3Phototransduction_Homo sapiens_hsa047442.37422854
4Renal cell carcinoma_Homo sapiens_hsa052112.20257527
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.05167495
6Systemic lupus erythematosus_Homo sapiens_hsa053221.75661236
7Thyroid cancer_Homo sapiens_hsa052161.71538158
8RNA transport_Homo sapiens_hsa030131.59477083
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58735551
10Long-term potentiation_Homo sapiens_hsa047201.58246370
11Measles_Homo sapiens_hsa051621.55378640
12Mismatch repair_Homo sapiens_hsa034301.54340657
13Fanconi anemia pathway_Homo sapiens_hsa034601.52410807
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50898544
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49781491
16Non-homologous end-joining_Homo sapiens_hsa034501.35796851
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34246581
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.28236402
19Alcoholism_Homo sapiens_hsa050341.27514932
20TNF signaling pathway_Homo sapiens_hsa046681.27414168
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25269998
22Hematopoietic cell lineage_Homo sapiens_hsa046401.22178135
23Leishmaniasis_Homo sapiens_hsa051401.22010951
24Long-term depression_Homo sapiens_hsa047301.20767206
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19503639
26Allograft rejection_Homo sapiens_hsa053301.16371598
27Sphingolipid metabolism_Homo sapiens_hsa006001.16061266
28Adherens junction_Homo sapiens_hsa045201.15123529
29Herpes simplex infection_Homo sapiens_hsa051681.14909051
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13611857
31Malaria_Homo sapiens_hsa051441.12887278
32Hepatitis B_Homo sapiens_hsa051611.11918131
33MicroRNAs in cancer_Homo sapiens_hsa052061.11644039
34DNA replication_Homo sapiens_hsa030301.11213320
35Prostate cancer_Homo sapiens_hsa052151.10334339
36Graft-versus-host disease_Homo sapiens_hsa053321.10320575
37Viral carcinogenesis_Homo sapiens_hsa052031.09087090
38Glioma_Homo sapiens_hsa052141.08619200
39Primary immunodeficiency_Homo sapiens_hsa053401.07682337
40Chemokine signaling pathway_Homo sapiens_hsa040621.06711596
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.06277176
42Bladder cancer_Homo sapiens_hsa052191.06171154
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05618533
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05363817
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04884582
46Olfactory transduction_Homo sapiens_hsa047401.04483223
47Chronic myeloid leukemia_Homo sapiens_hsa052201.03783538
48T cell receptor signaling pathway_Homo sapiens_hsa046601.03664199
49Dorso-ventral axis formation_Homo sapiens_hsa043201.02914985
50B cell receptor signaling pathway_Homo sapiens_hsa046621.01371514
51Osteoclast differentiation_Homo sapiens_hsa043801.00226251
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99959189
53Type I diabetes mellitus_Homo sapiens_hsa049400.99825172
54Endometrial cancer_Homo sapiens_hsa052130.99794436
55N-Glycan biosynthesis_Homo sapiens_hsa005100.99280001
56Spliceosome_Homo sapiens_hsa030400.99061559
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96778046
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96714217
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96546757
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96143903
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93664988
62Prolactin signaling pathway_Homo sapiens_hsa049170.92475744
63Influenza A_Homo sapiens_hsa051640.92394656
64Autoimmune thyroid disease_Homo sapiens_hsa053200.91911491
65mRNA surveillance pathway_Homo sapiens_hsa030150.89459803
66Small cell lung cancer_Homo sapiens_hsa052220.88952456
67p53 signaling pathway_Homo sapiens_hsa041150.88930246
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88713521
69FoxO signaling pathway_Homo sapiens_hsa040680.88305320
70Cell cycle_Homo sapiens_hsa041100.88207350
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87876702
72Tuberculosis_Homo sapiens_hsa051520.87782481
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87692205
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85518926
75Pancreatic cancer_Homo sapiens_hsa052120.84852390
76Apoptosis_Homo sapiens_hsa042100.84382015
77Phagosome_Homo sapiens_hsa041450.83908591
78Hepatitis C_Homo sapiens_hsa051600.83664475
79mTOR signaling pathway_Homo sapiens_hsa041500.83342230
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83270708
81Butanoate metabolism_Homo sapiens_hsa006500.83159204
82Type II diabetes mellitus_Homo sapiens_hsa049300.82399790
83ErbB signaling pathway_Homo sapiens_hsa040120.82150801
84Colorectal cancer_Homo sapiens_hsa052100.82111754
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80759243
86Axon guidance_Homo sapiens_hsa043600.78289882
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77143730
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76375268
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76024657
90Legionellosis_Homo sapiens_hsa051340.75190120
91Toxoplasmosis_Homo sapiens_hsa051450.74673738
92Rheumatoid arthritis_Homo sapiens_hsa053230.72525029
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72089062
94Basal transcription factors_Homo sapiens_hsa030220.71817199
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70013721
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69328151
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68974698
98Antigen processing and presentation_Homo sapiens_hsa046120.67960200
99RNA degradation_Homo sapiens_hsa030180.67858839
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67561648
101Acute myeloid leukemia_Homo sapiens_hsa052210.66933153
102Cholinergic synapse_Homo sapiens_hsa047250.65787467
103Gap junction_Homo sapiens_hsa045400.65776062
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65197293
105Inositol phosphate metabolism_Homo sapiens_hsa005620.64853265
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63280784
107Melanoma_Homo sapiens_hsa052180.63128323
108African trypanosomiasis_Homo sapiens_hsa051430.62595086
109Circadian rhythm_Homo sapiens_hsa047100.62086917
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60917810
111Non-small cell lung cancer_Homo sapiens_hsa052230.60524468
112HIF-1 signaling pathway_Homo sapiens_hsa040660.60371341
113Regulation of autophagy_Homo sapiens_hsa041400.58493184
114Morphine addiction_Homo sapiens_hsa050320.58141359
115HTLV-I infection_Homo sapiens_hsa051660.57422211
116Epstein-Barr virus infection_Homo sapiens_hsa051690.57326649
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56654678
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56420817
119Estrogen signaling pathway_Homo sapiens_hsa049150.56355061
120Oocyte meiosis_Homo sapiens_hsa041140.56194376
121Asthma_Homo sapiens_hsa053100.55900139
122TGF-beta signaling pathway_Homo sapiens_hsa043500.55400748
123Hippo signaling pathway_Homo sapiens_hsa043900.54702191
124Salmonella infection_Homo sapiens_hsa051320.54674603
125Pertussis_Homo sapiens_hsa051330.54228805
126MAPK signaling pathway_Homo sapiens_hsa040100.53843963
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52732118
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52729064
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52495425
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.52458978
131Platelet activation_Homo sapiens_hsa046110.52398154
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.52018411
133Pathways in cancer_Homo sapiens_hsa052000.51756721
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.51378793
135Proteoglycans in cancer_Homo sapiens_hsa052050.51321449
136Insulin signaling pathway_Homo sapiens_hsa049100.50498182
137Basal cell carcinoma_Homo sapiens_hsa052170.49993487
138Ras signaling pathway_Homo sapiens_hsa040140.49855327
139GnRH signaling pathway_Homo sapiens_hsa049120.49517002
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.45502732
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44949327
142Homologous recombination_Homo sapiens_hsa034400.44899949
143Wnt signaling pathway_Homo sapiens_hsa043100.42660767

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »