ZBTB7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91323319
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89262368
3L-phenylalanine catabolic process (GO:0006559)4.89262368
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.88947449
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88817134
6negative regulation of cell killing (GO:0031342)4.86634722
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86634722
8L-phenylalanine metabolic process (GO:0006558)4.80786374
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.80786374
10sulfur amino acid catabolic process (GO:0000098)4.80467911
11antigen processing and presentation of endogenous antigen (GO:0019883)4.73214809
12neurofilament cytoskeleton organization (GO:0060052)4.64184484
13detection of other organism (GO:0098543)4.57798042
14detection of bacterium (GO:0016045)4.57731551
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55125135
16regulation of DNA methylation (GO:0044030)4.52072034
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.49747336
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.49747336
19modulation by symbiont of host immune response (GO:0052553)4.49747336
20positive regulation by symbiont of host defense response (GO:0052509)4.49747336
21modulation by symbiont of host defense response (GO:0052031)4.49747336
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.49747336
23alpha-linolenic acid metabolic process (GO:0036109)4.45497734
24regulation of interferon-beta biosynthetic process (GO:0045357)4.33962186
25aromatic amino acid family catabolic process (GO:0009074)4.33868587
26cysteine metabolic process (GO:0006534)4.32849599
27regulation of triglyceride catabolic process (GO:0010896)4.30837287
28regulation of cholesterol homeostasis (GO:2000188)4.23964527
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.20344877
30urea metabolic process (GO:0019627)4.19806489
31urea cycle (GO:0000050)4.19806489
32complement activation, alternative pathway (GO:0006957)4.03840805
33negative regulation of glycoprotein biosynthetic process (GO:0010561)4.02508800
34protein carboxylation (GO:0018214)4.01501000
35peptidyl-glutamic acid carboxylation (GO:0017187)4.01501000
36kynurenine metabolic process (GO:0070189)4.01096153
37phospholipid efflux (GO:0033700)4.00695324
38high-density lipoprotein particle remodeling (GO:0034375)4.00241391
39negative regulation of erythrocyte differentiation (GO:0045647)3.98745548
40plasma lipoprotein particle clearance (GO:0034381)3.93520170
41indole-containing compound catabolic process (GO:0042436)3.91441254
42indolalkylamine catabolic process (GO:0046218)3.91441254
43tryptophan catabolic process (GO:0006569)3.91441254
44intestinal cholesterol absorption (GO:0030299)3.89910002
45positive regulation of gamma-delta T cell activation (GO:0046645)3.89831275
46negative regulation of cholesterol transport (GO:0032375)3.88459113
47negative regulation of sterol transport (GO:0032372)3.88459113
48negative regulation of fibrinolysis (GO:0051918)3.85465079
49low-density lipoprotein particle clearance (GO:0034383)3.84643318
50nitrogen cycle metabolic process (GO:0071941)3.84414496
51homocysteine metabolic process (GO:0050667)3.84055401
52glyoxylate metabolic process (GO:0046487)3.81971604
53bile acid biosynthetic process (GO:0006699)3.74590567
54neutrophil activation involved in immune response (GO:0002283)3.73686251
55detection of external biotic stimulus (GO:0098581)3.72965051
56macrophage activation involved in immune response (GO:0002281)3.70033689
57tryptophan metabolic process (GO:0006568)3.69940576
58reverse cholesterol transport (GO:0043691)3.68186275
59lysine catabolic process (GO:0006554)3.66379349
60lysine metabolic process (GO:0006553)3.66379349
61regulation of natural killer cell mediated immunity (GO:0002715)3.65833129
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.65833129
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.63502682
64regulation of protein activation cascade (GO:2000257)3.63401170
65triglyceride homeostasis (GO:0070328)3.60266257
66acylglycerol homeostasis (GO:0055090)3.60266257
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.59194392
68regulation of cholesterol esterification (GO:0010872)3.58959598
69amino-acid betaine metabolic process (GO:0006577)3.58515460
70positive regulation of lipid catabolic process (GO:0050996)3.58050024
71positive regulation of keratinocyte differentiation (GO:0045618)3.55674545
72response to peptidoglycan (GO:0032494)3.54710616
73bile acid metabolic process (GO:0008206)3.51714591
74phospholipid homeostasis (GO:0055091)3.50459313
75plasma lipoprotein particle remodeling (GO:0034369)3.49662465
76protein-lipid complex remodeling (GO:0034368)3.49662465
77macromolecular complex remodeling (GO:0034367)3.49662465
78serine family amino acid catabolic process (GO:0009071)3.48849974
79plasma lipoprotein particle assembly (GO:0034377)3.46866248
80positive regulation of lipoprotein lipase activity (GO:0051006)3.46492160
81positive regulation of triglyceride lipase activity (GO:0061365)3.46492160
82regulation of complement activation (GO:0030449)3.46158051
83regulation of fibrinolysis (GO:0051917)3.45490276
84bile acid and bile salt transport (GO:0015721)3.45292379
85cholesterol efflux (GO:0033344)3.41535480
86positive regulation of triglyceride metabolic process (GO:0090208)3.40388551
87intestinal absorption (GO:0050892)3.38163176
88valine metabolic process (GO:0006573)3.37442946
89cholesterol homeostasis (GO:0042632)3.36869427
90protein-lipid complex assembly (GO:0065005)3.36628557
91sterol homeostasis (GO:0055092)3.33855787
92leukocyte aggregation (GO:0070486)3.32345909
93fatty acid beta-oxidation (GO:0006635)3.28681882
94ethanol oxidation (GO:0006069)3.26077711
95lipoprotein metabolic process (GO:0042157)3.24847298
96fatty acid oxidation (GO:0019395)3.23187717
97negative regulation of glycoprotein metabolic process (GO:1903019)3.22752753
98drug catabolic process (GO:0042737)3.21508130
99detection of biotic stimulus (GO:0009595)3.20185499
100cellular modified amino acid catabolic process (GO:0042219)3.19728250
101regulation of fatty acid beta-oxidation (GO:0031998)3.19709114
102immunoglobulin mediated immune response (GO:0016064)3.19688448
103regulation of cholesterol storage (GO:0010885)3.16756310
104lipid oxidation (GO:0034440)3.16391635
105acetyl-CoA metabolic process (GO:0006084)3.15648671
106cellular response to thyroid hormone stimulus (GO:0097067)3.15492516
107germinal center formation (GO:0002467)3.14092932
108aromatic amino acid family metabolic process (GO:0009072)3.13714482
109flavonoid metabolic process (GO:0009812)3.13347418
110regulation of gamma-delta T cell activation (GO:0046643)3.08854060
111detection of molecule of bacterial origin (GO:0032490)3.06690023
112fatty acid catabolic process (GO:0009062)3.06396926
113cellular glucuronidation (GO:0052695)3.05191422
114epoxygenase P450 pathway (GO:0019373)3.05183422
115alpha-amino acid catabolic process (GO:1901606)3.02663199
116regulation of bile acid biosynthetic process (GO:0070857)3.01996260
1172-oxoglutarate metabolic process (GO:0006103)3.01683640
118tyrosine metabolic process (GO:0006570)2.99054543
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.98596399
120negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.98210273
121positive regulation of fatty acid oxidation (GO:0046321)2.97322398
122regulation of triglyceride metabolic process (GO:0090207)2.95446380
123respiratory burst (GO:0045730)2.94972043
124plasma lipoprotein particle organization (GO:0071827)2.94329016
125production of molecular mediator involved in inflammatory response (GO:0002532)2.94136042
126regulation of cholesterol metabolic process (GO:0090181)2.94013046
127very-low-density lipoprotein particle assembly (GO:0034379)2.93699669
128fibrinolysis (GO:0042730)2.93479268
129cellular amino acid catabolic process (GO:0009063)2.92612970
130protein-lipid complex subunit organization (GO:0071825)2.91774049
131regulation of cholesterol transport (GO:0032374)2.91773178
132regulation of sterol transport (GO:0032371)2.91773178
133negative regulation of lipase activity (GO:0060192)2.91440941
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91206385
135response to host immune response (GO:0052572)2.91206385
136lipid homeostasis (GO:0055088)2.91003423
137fatty acid transmembrane transport (GO:1902001)2.89033178
138cellular ketone body metabolic process (GO:0046950)2.88841996
139neutrophil activation (GO:0042119)2.88400349
140monocarboxylic acid catabolic process (GO:0072329)2.88149773
141ethanol metabolic process (GO:0006067)2.87924733
142carnitine metabolic process (GO:0009437)2.86674893
143positive regulation of fatty acid biosynthetic process (GO:0045723)2.85800526
144hydrogen peroxide biosynthetic process (GO:0050665)2.84531143
145cellular extravasation (GO:0045123)2.84422155
146type I interferon signaling pathway (GO:0060337)2.83982441
147cellular response to type I interferon (GO:0071357)2.83982441
148response to type I interferon (GO:0034340)2.83731622
149negative regulation of leukocyte mediated immunity (GO:0002704)2.79762540
150positive regulation of Cdc42 GTPase activity (GO:0043089)2.79245217
151thymic T cell selection (GO:0045061)2.78604185
152response to host (GO:0075136)2.77818429
153response to host defenses (GO:0052200)2.77818429
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77818429
155regulation of B cell receptor signaling pathway (GO:0050855)2.77634270
156megakaryocyte development (GO:0035855)2.77048669
157regulation of gamma-delta T cell differentiation (GO:0045586)2.75584903
158negative regulation of interleukin-12 production (GO:0032695)2.74173125
159response to interleukin-15 (GO:0070672)2.73807448
160lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73237814
161regulation of mast cell degranulation (GO:0043304)2.71603163
162granulocyte activation (GO:0036230)2.70329621
163regulation of T-helper 2 cell differentiation (GO:0045628)2.65398474
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.64600270
165antigen processing and presentation via MHC class Ib (GO:0002475)2.64012094
166regulation of leukocyte degranulation (GO:0043300)2.63778379
167leukocyte migration involved in inflammatory response (GO:0002523)2.63542478
168T cell selection (GO:0045058)2.62763091
169cellular response to interleukin-15 (GO:0071350)2.61394577
170regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60373685
171regulation of T cell tolerance induction (GO:0002664)2.58439286
172positive regulation of interferon-alpha production (GO:0032727)2.57611303
173B cell receptor signaling pathway (GO:0050853)2.57133960
174regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55900115
175response to thyroid hormone (GO:0097066)2.55474263
176positive regulation of epidermal cell differentiation (GO:0045606)2.53925435
177regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53174648
178negative regulation of fatty acid biosynthetic process (GO:0045717)2.53046359
179reactive oxygen species biosynthetic process (GO:1903409)2.52670437
180regulation of antigen processing and presentation (GO:0002577)2.52147141
181positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52083443
182response to laminar fluid shear stress (GO:0034616)2.52055921
183response to muramyl dipeptide (GO:0032495)2.51602492
184regulation of cellular amide metabolic process (GO:0034248)2.50935038
185positive regulation of cellular amide metabolic process (GO:0034250)2.49832528
186negative regulation of toll-like receptor signaling pathway (GO:0034122)2.47904692
187positive thymic T cell selection (GO:0045059)2.46900523
188negative regulation of T cell mediated immunity (GO:0002710)2.45591828
189macrophage activation (GO:0042116)2.45276875
190cellular response to virus (GO:0098586)2.45255285
191positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43758248
192positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.42633331
193regulation of defense response to virus by virus (GO:0050690)2.41535358
194mast cell activation (GO:0045576)2.41289951
195interferon-gamma-mediated signaling pathway (GO:0060333)2.40579251
196regulation of tolerance induction (GO:0002643)2.40386650
197negative regulation of innate immune response (GO:0045824)2.38473714
198regulation of mast cell activation involved in immune response (GO:0033006)2.38273086
199dendritic cell chemotaxis (GO:0002407)2.35182338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.11181459
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.34664585
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.96887110
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91465657
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.34735946
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.31964849
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.39108127
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.36269743
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77822091
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75274376
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.63989436
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.53105470
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35610330
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29608072
15CLOCK_20551151_ChIP-Seq_293T_Human2.24763027
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19807361
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08941804
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07458166
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03684871
20* RUNX1_22412390_ChIP-Seq_EML_Mouse2.02447507
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97701284
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92211051
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91707880
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.83814920
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82162741
26SPI1_23127762_ChIP-Seq_K562_Human1.80239267
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79519737
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73569176
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.71003012
30SCL_19346495_ChIP-Seq_HPC-7_Human1.70483469
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67928677
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64732734
33ZNF263_19887448_ChIP-Seq_K562_Human1.64070339
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63113195
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62061812
36* MAF_26560356_Chip-Seq_TH2_Human1.61754313
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60287790
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54332439
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.53073812
40RUNX_20019798_ChIP-Seq_JUKART_Human1.51460002
41* LXR_22292898_ChIP-Seq_THP-1_Human1.47749378
42* KDM2B_26808549_Chip-Seq_K562_Human1.46889864
43SPI1_23547873_ChIP-Seq_NB4_Human1.44424235
44* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43947467
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.41436952
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41044765
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.40232044
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38614443
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38237197
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38163124
51GATA4_25053715_ChIP-Seq_YYC3_Human1.37959187
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37879369
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36695505
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.36308923
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35641747
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33718633
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.33369326
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33237703
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.33080018
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.32559817
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.31911178
62* GATA6_25053715_ChIP-Seq_YYC3_Human1.31649892
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30731141
64* MYB_26560356_Chip-Seq_TH1_Human1.28929853
65* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28883570
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28456323
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28284011
68ATF3_27146783_Chip-Seq_COLON_Human1.27014204
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26969035
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26866239
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.26427147
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25636632
73* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25480468
74MYB_26560356_Chip-Seq_TH2_Human1.24988710
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.24824667
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24807075
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24503502
78VDR_24787735_ChIP-Seq_THP-1_Human1.23455711
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23064980
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22982678
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21809955
82SMC4_20622854_ChIP-Seq_HELA_Human1.20675877
83* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18983179
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17053589
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16353300
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14519537
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14131802
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.13097592
89* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11539825
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09394206
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.09045851
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09038357
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08772500
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08281086
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08019975
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07853260
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07447483
98* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06623546
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06009547
100* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04275215
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04203982
102* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04162518
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04021794
104BCL6_27268052_Chip-Seq_Bcells_Human1.03824163
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03484073
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03264429
107* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02224734
108* VDR_21846776_ChIP-Seq_THP-1_Human1.00242658
109* MAF_26560356_Chip-Seq_TH1_Human0.99994937
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99407369
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.98534968
112* KDM2B_26808549_Chip-Seq_DND41_Human0.98477951
113* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98404936
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97939724
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97798779
116SOX2_20726797_ChIP-Seq_SW620_Human0.97440026
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96314739
118* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96310785
119* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96068242
120* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95986246
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95343614
122GATA1_19941826_ChIP-Seq_K562_Human0.94213147
123GATA1_22025678_ChIP-Seq_K562_Human0.93740055
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92264358
125GATA2_19941826_ChIP-Seq_K562_Human0.92208888
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91433913
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91325260
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90247574
129IRF8_21731497_ChIP-ChIP_J774_Mouse0.88779635
130BCOR_27268052_Chip-Seq_Bcells_Human0.88706032
131* MYC_22102868_ChIP-Seq_BL_Human0.86929248
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.84088209
133* UTX_26944678_Chip-Seq_JUKART_Human0.82874816
134* GATA3_24758297_ChIP-Seq_MCF-7_Human0.81591208
135* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80703655
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79823909
137* TBX20_22080862_ChIP-Seq_HEART_Mouse0.79625337
138* TBX20_22328084_ChIP-Seq_HEART_Mouse0.79625337
139* CREB1_26743006_Chip-Seq_LNCaP_Human0.78013802
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77268349
141* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76959784
142* P68_20966046_ChIP-Seq_HELA_Human0.76648002
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76119317
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76119317
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75965964
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75821918
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75592681
148* NCOR1_26117541_ChIP-Seq_K562_Human0.74775611
149VDR_24763502_ChIP-Seq_THP-1_Human0.74608194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.73545439
2MP0002139_abnormal_hepatobiliary_system5.43224989
3MP0005365_abnormal_bile_salt4.30614157
4MP0005085_abnormal_gallbladder_physiolo4.15313863
5MP0009840_abnormal_foam_cell3.52098112
6MP0008875_abnormal_xenobiotic_pharmacok3.36267152
7MP0003705_abnormal_hypodermis_morpholog3.00091575
8MP0003252_abnormal_bile_duct2.95937792
9MP0010329_abnormal_lipoprotein_level2.90569047
10MP0008995_early_reproductive_senescence2.79222360
11MP0003191_abnormal_cellular_cholesterol2.71138251
12MP0001666_abnormal_nutrient_absorption2.66147109
13MP0003763_abnormal_thymus_physiology2.64517076
14MP0005671_abnormal_response_to2.55661246
15MP0003806_abnormal_nucleotide_metabolis2.52698421
16MP0001835_abnormal_antigen_presentation2.51546073
17MP0009785_altered_susceptibility_to2.29330003
18MP0005000_abnormal_immune_tolerance2.17450601
19MP0001800_abnormal_humoral_immune2.16145333
20MP0005083_abnormal_biliary_tract2.08268627
21MP0009333_abnormal_splenocyte_physiolog2.01967966
22MP0010234_abnormal_vibrissa_follicle2.01362423
23MP0000609_abnormal_liver_physiology1.98193487
24MP0005332_abnormal_amino_acid1.94092995
25* MP0002420_abnormal_adaptive_immunity1.89245188
26* MP0002723_abnormal_immune_serum1.88327484
27* MP0001819_abnormal_immune_cell1.87248862
28MP0002796_impaired_skin_barrier1.85015741
29MP0002452_abnormal_antigen_presenting1.82483309
30MP0002118_abnormal_lipid_homeostasis1.81414173
31MP0004019_abnormal_vitamin_homeostasis1.81176620
32MP0005670_abnormal_white_adipose1.75084128
33MP0008260_abnormal_autophagy1.71742825
34MP0003300_gastrointestinal_ulcer1.70431549
35MP0004381_abnormal_hair_follicle1.64851140
36MP0002132_abnormal_respiratory_system1.63777494
37MP0002148_abnormal_hypersensitivity_rea1.63508473
38MP0004185_abnormal_adipocyte_glucose1.60045976
39MP0002254_reproductive_system_inflammat1.57923067
40MP0003195_calcinosis1.54176090
41MP0005319_abnormal_enzyme/_coenzyme1.52638511
42MP0000858_altered_metastatic_potential1.47311020
43* MP0002398_abnormal_bone_marrow1.46838054
44MP0003828_pulmonary_edema1.46765123
45MP0003183_abnormal_peptide_metabolism1.45306656
46MP0005666_abnormal_adipose_tissue1.45180197
47* MP0000716_abnormal_immune_system1.45096179
48MP0005451_abnormal_body_composition1.45066366
49MP0009643_abnormal_urine_homeostasis1.42389782
50MP0002138_abnormal_hepatobiliary_system1.41817080
51MP0002998_abnormal_bone_remodeling1.39963432
52MP0002405_respiratory_system_inflammati1.38663872
53MP0004947_skin_inflammation1.36271611
54MP0003436_decreased_susceptibility_to1.35825558
55MP0003453_abnormal_keratinocyte_physiol1.33435338
56MP0005058_abnormal_lysosome_morphology1.31311137
57MP0005275_abnormal_skin_tensile1.31297183
58MP0004858_abnormal_nervous_system1.28038943
59MP0004130_abnormal_muscle_cell1.25293565
60MP0002060_abnormal_skin_morphology1.24582418
61MP0003172_abnormal_lysosome_physiology1.24026746
62MP0003566_abnormal_cell_adhesion1.23295844
63MP0010352_gastrointestinal_tract_polyps1.21277069
64MP0008438_abnormal_cutaneous_collagen1.20875679
65MP0001851_eye_inflammation1.20827141
66* MP0002429_abnormal_blood_cell1.20435036
67MP0004264_abnormal_extraembryonic_tissu1.20266556
68MP0000465_gastrointestinal_hemorrhage1.17777507
69MP0002722_abnormal_immune_system1.14984512
70MP0005584_abnormal_enzyme/coenzyme_acti1.14705163
71MP0009278_abnormal_bone_marrow1.11108270
72MP0003303_peritoneal_inflammation1.10064749
73MP0002971_abnormal_brown_adipose1.07262903
74MP0004510_myositis1.06190811
75MP0005409_darkened_coat_color1.05907997
76MP0003868_abnormal_feces_composition1.05043083
77MP0005310_abnormal_salivary_gland1.03653257
78MP0005023_abnormal_wound_healing1.03368655
79MP0000598_abnormal_liver_morphology1.02943584
80MP0005501_abnormal_skin_physiology1.02405321
81MP0000490_abnormal_crypts_of1.02042554
82MP0005375_adipose_tissue_phenotype1.01451158
83MP0000703_abnormal_thymus_morphology1.00060233
84MP0008469_abnormal_protein_level0.98672269
85MP0000689_abnormal_spleen_morphology0.97688710
86MP0000604_amyloidosis0.97523321
87MP0006082_CNS_inflammation0.97521365
88MP0010155_abnormal_intestine_physiology0.96231328
89MP0001216_abnormal_epidermal_layer0.95529551
90MP0002396_abnormal_hematopoietic_system0.90362554
91MP0001764_abnormal_homeostasis0.89545827
92MP0009764_decreased_sensitivity_to0.88615881
93MP0002876_abnormal_thyroid_physiology0.88152873
94MP0000678_abnormal_parathyroid_gland0.88130128
95MP0000343_altered_response_to0.87912873
96MP0005464_abnormal_platelet_physiology0.87670868
97MP0005334_abnormal_fat_pad0.87073734
98MP0009115_abnormal_fat_cell0.85665725
99MP0008004_abnormal_stomach_pH0.84288902
100MP0001873_stomach_inflammation0.84011636
101MP0001756_abnormal_urination0.82471016
102MP0005390_skeleton_phenotype0.82248160
103MP0003186_abnormal_redox_activity0.82064332
104MP0003448_altered_tumor_morphology0.81388072
105MP0009763_increased_sensitivity_to0.80899992
106MP0002136_abnormal_kidney_physiology0.80579729
107MP0001663_abnormal_digestive_system0.80470054
108MP0000579_abnormal_nail_morphology0.80448884
109MP0001533_abnormal_skeleton_physiology0.79360040
110MP0003656_abnormal_erythrocyte_physiolo0.78598342
111MP0002653_abnormal_ependyma_morphology0.78253961
112MP0000685_abnormal_immune_system0.77221046
113MP0001845_abnormal_inflammatory_respons0.77005928
114MP0001881_abnormal_mammary_gland0.76316639
115MP0000249_abnormal_blood_vessel0.75128451
116MP0002166_altered_tumor_susceptibility0.73948933
117MP0003786_premature_aging0.72908351
118MP0005397_hematopoietic_system_phenotyp0.72642740
119MP0001545_abnormal_hematopoietic_system0.72642740
120MP0009642_abnormal_blood_homeostasis0.72331851
121MP0003724_increased_susceptibility_to0.71283237
122MP0003011_delayed_dark_adaptation0.70264531
123MP0005636_abnormal_mineral_homeostasis0.70122952
124MP0001243_abnormal_dermal_layer0.69880266
125MP0000377_abnormal_hair_follicle0.69579181
126MP0004883_abnormal_blood_vessel0.69362124
127MP0005076_abnormal_cell_differentiation0.69222131
128MP0005448_abnormal_energy_balance0.68221988
129MP0005387_immune_system_phenotype0.67652999
130MP0001790_abnormal_immune_system0.67652999
131MP0005025_abnormal_response_to0.66348976
132MP0002078_abnormal_glucose_homeostasis0.65067629
133MP0002419_abnormal_innate_immunity0.64687954
134MP0001849_ear_inflammation0.64286968
135MP0003075_altered_response_to0.64156708
136MP0003866_abnormal_defecation0.62667096
137MP0009931_abnormal_skin_appearance0.62454810
138MP0003045_fibrosis0.61595700
139MP0002970_abnormal_white_adipose0.61253594
140MP0009384_cardiac_valve_regurgitation0.60435010
141MP0002168_other_aberrant_phenotype0.59561634
142MP0005166_decreased_susceptibility_to0.57914421
143MP0000477_abnormal_intestine_morphology0.57589848
144MP0004782_abnormal_surfactant_physiolog0.57555498
145MP0000467_abnormal_esophagus_morphology0.57261776
146MP0002098_abnormal_vibrissa_morphology0.56682166
147MP0000003_abnormal_adipose_tissue0.56472788
148MP0010678_abnormal_skin_adnexa0.54945378
149MP0008961_abnormal_basal_metabolism0.54736757
150MP0009765_abnormal_xenobiotic_induced0.54605687

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.23582610
2Deep venous thrombosis (HP:0002625)5.05127670
3Intrahepatic cholestasis (HP:0001406)4.93645085
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.58692048
5Duplicated collecting system (HP:0000081)4.55297351
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.45208431
7Complement deficiency (HP:0004431)4.28832828
8Abnormality of macrophages (HP:0004311)4.25450965
9Hypobetalipoproteinemia (HP:0003563)4.19552632
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90736279
11Hyperlipoproteinemia (HP:0010980)3.88693702
12Recurrent bacterial skin infections (HP:0005406)3.84046901
13Abnormality of the renal collecting system (HP:0004742)3.83367386
14Recurrent abscess formation (HP:0002722)3.78351816
15Hyperglycinuria (HP:0003108)3.67651761
16Myocardial infarction (HP:0001658)3.63344854
17Hypolipoproteinemia (HP:0010981)3.61194972
18Prolonged partial thromboplastin time (HP:0003645)3.54376775
19Hypoalphalipoproteinemia (HP:0003233)3.49070733
20Oral leukoplakia (HP:0002745)3.48764697
21Epidermoid cyst (HP:0200040)3.47343130
22Ureteral duplication (HP:0000073)3.46334082
23Hyperammonemia (HP:0001987)3.45966817
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41710727
25Abnormality of complement system (HP:0005339)3.38116420
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.36785327
27Myositis (HP:0100614)3.34142486
28Abnormality of serine family amino acid metabolism (HP:0010894)3.33432909
29Abnormality of glycine metabolism (HP:0010895)3.33432909
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.32480272
31Orchitis (HP:0100796)3.22742076
32Reticulocytopenia (HP:0001896)3.20395292
33Abnormality of the common coagulation pathway (HP:0010990)3.19600153
34Gastrointestinal infarctions (HP:0005244)3.19390830
35Ketosis (HP:0001946)3.17780461
36Systemic lupus erythematosus (HP:0002725)3.16580786
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.16308989
38Fat malabsorption (HP:0002630)3.09210955
39Hypoglycemic coma (HP:0001325)3.06763598
40Joint hemorrhage (HP:0005261)3.02188678
41Hyperglycinemia (HP:0002154)3.01598588
42Right ventricular cardiomyopathy (HP:0011663)2.98957563
43Hypochromic anemia (HP:0001931)2.93683299
44Abnormality of T cell number (HP:0011839)2.89520505
45Hypercholesterolemia (HP:0003124)2.88991671
46Cellulitis (HP:0100658)2.83727019
47Gingivitis (HP:0000230)2.82033940
48Abnormality of fatty-acid metabolism (HP:0004359)2.81694018
49Retrobulbar optic neuritis (HP:0100654)2.79515589
50Optic neuritis (HP:0100653)2.79515589
51Granulocytopenia (HP:0001913)2.77843282
52Chromsome breakage (HP:0040012)2.76458461
53Urticaria (HP:0001025)2.76378791
54Abnormality of purine metabolism (HP:0004352)2.75157818
55Increased IgM level (HP:0003496)2.74361334
56Meningitis (HP:0001287)2.73279047
57Malnutrition (HP:0004395)2.70426677
58Abnormality of proline metabolism (HP:0010907)2.70129414
59Hydroxyprolinuria (HP:0003080)2.70129414
60Abnormality of DNA repair (HP:0003254)2.68946114
61Aplastic anemia (HP:0001915)2.67521502
62Vasculitis (HP:0002633)2.67304831
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.65876560
64Enlarged epiphyses (HP:0010580)2.65010465
65Autoimmune hemolytic anemia (HP:0001890)2.64786992
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.61063648
67Abnormality of the intrinsic pathway (HP:0010989)2.59954279
68Eosinophilia (HP:0001880)2.58935276
69Obstructive lung disease (HP:0006536)2.58372275
70Chronic obstructive pulmonary disease (HP:0006510)2.58372275
71Joint swelling (HP:0001386)2.53774522
72Recurrent skin infections (HP:0001581)2.52959220
73Recurrent fungal infections (HP:0002841)2.52076429
74Esophageal varix (HP:0002040)2.51617460
75Mediastinal lymphadenopathy (HP:0100721)2.50637190
76Ketoacidosis (HP:0001993)2.49549671
77Ileus (HP:0002595)2.48881998
78Abnormality of nucleobase metabolism (HP:0010932)2.45355436
79Recurrent gram-negative bacterial infections (HP:0005420)2.44250264
80Skin nodule (HP:0200036)2.42853603
81Conjugated hyperbilirubinemia (HP:0002908)2.41996921
82Abnormality of T cells (HP:0002843)2.41861411
83Alopecia of scalp (HP:0002293)2.37303674
84Spontaneous hematomas (HP:0007420)2.34696196
85Vascular calcification (HP:0004934)2.34613920
86Pustule (HP:0200039)2.32340927
87Duplication of thumb phalanx (HP:0009942)2.30274878
88Flattened epiphyses (HP:0003071)2.30185850
89Recurrent viral infections (HP:0004429)2.29171347
90Hemorrhage of the eye (HP:0011885)2.27746951
91Peritonitis (HP:0002586)2.24681237
92Increased serum ferritin (HP:0003281)2.23088244
93T lymphocytopenia (HP:0005403)2.22441442
94Elevated erythrocyte sedimentation rate (HP:0003565)2.21488750
95Glomerulonephritis (HP:0000099)2.21300151
96Gout (HP:0001997)2.21268227
97Keratoconjunctivitis sicca (HP:0001097)2.20376309
98Cardiovascular calcification (HP:0011915)2.19965876
99Abnormal cartilage morphology (HP:0002763)2.16779829
100Amyloidosis (HP:0011034)2.16553967
101Nephritis (HP:0000123)2.15980057
102Autoimmune thrombocytopenia (HP:0001973)2.15119816
103Abnormality of methionine metabolism (HP:0010901)2.12614835
104Leukocytosis (HP:0001974)2.12594265
105Encephalitis (HP:0002383)2.12512385
106Spinal cord lesions (HP:0100561)2.10778156
107Syringomyelia (HP:0003396)2.10778156
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10698495
109Dicarboxylic aciduria (HP:0003215)2.10698495
110Hepatocellular carcinoma (HP:0001402)2.10679219
111Spastic diplegia (HP:0001264)2.10623199
112Recurrent cutaneous fungal infections (HP:0011370)2.10011388
113Chronic mucocutaneous candidiasis (HP:0002728)2.10011388
114Gastrointestinal inflammation (HP:0004386)2.09104977
115Colitis (HP:0002583)2.07454208
116Prolonged bleeding time (HP:0003010)2.06962297
117Abnormality of cells of the lymphoid lineage (HP:0012140)2.06363673
118Gingival bleeding (HP:0000225)2.06278399
119Eczematoid dermatitis (HP:0000976)2.06255042
120Steatorrhea (HP:0002570)2.06146021
121Inflammation of the large intestine (HP:0002037)2.05035054
122Polycythemia (HP:0001901)2.04607137
123Hemoptysis (HP:0002105)2.03749984
124Pancreatitis (HP:0001733)2.02150098
125Hypergammaglobulinemia (HP:0010702)2.00969118
126Increased mean platelet volume (HP:0011877)2.00534002
127Late onset (HP:0003584)1.99186408
128Hyperbilirubinemia (HP:0002904)1.98808534
129Thin bony cortex (HP:0002753)1.98253584
130Thoracic kyphosis (HP:0002942)1.97684613
131Axonal loss (HP:0003447)1.97642928
132Chest pain (HP:0100749)1.96611802
133Metabolic acidosis (HP:0001942)1.95245215
134Mitral stenosis (HP:0001718)1.94289211
135Osteomyelitis (HP:0002754)1.93894511
136Menorrhagia (HP:0000132)1.93874649
137Hypertriglyceridemia (HP:0002155)1.93716571
138Skin ulcer (HP:0200042)1.92956306
139Keratoconjunctivitis (HP:0001096)1.92924128
140Nasal polyposis (HP:0100582)1.91886508
141Progressive neurologic deterioration (HP:0002344)1.90739190
142Abdominal distention (HP:0003270)1.90382254
143Abnormality of the nasal mucosa (HP:0000433)1.90234560
144Protuberant abdomen (HP:0001538)1.89694661
145Rough bone trabeculation (HP:0100670)1.89607412
146Acanthocytosis (HP:0001927)1.89254234
147Cholelithiasis (HP:0001081)1.87923185
148Abnormality of the Achilles tendon (HP:0005109)1.86889436
149Abnormal platelet volume (HP:0011876)1.85947200
150Abnormality of transition element cation homeostasis (HP:0011030)1.85758350
151Abnormality of pyrimidine metabolism (HP:0004353)1.85750672
152Increased IgE level (HP:0003212)1.84113305
153Abnormal gallbladder morphology (HP:0012437)1.83338991
154Stomatitis (HP:0010280)1.83330199
155Abnormality of iron homeostasis (HP:0011031)1.82588110
156Sensorimotor neuropathy (HP:0007141)1.81956242
157Hypermelanotic macule (HP:0001034)1.81954639
158Epistaxis (HP:0000421)1.81574440
159Petechiae (HP:0000967)1.80862398
160Abnormal enzyme/coenzyme activity (HP:0012379)1.80576371
161Gastrointestinal stroma tumor (HP:0100723)1.80028838
162Increased connective tissue (HP:0009025)1.79579873
163Abnormality of B cell number (HP:0010975)1.79035527
164Hyperglycemia (HP:0003074)1.78071872
165Urinary glycosaminoglycan excretion (HP:0003541)1.77943388
166Mucopolysacchariduria (HP:0008155)1.77943388
167Myoglobinuria (HP:0002913)1.77864611
168Abnormality of eosinophils (HP:0001879)1.77695670
169Gangrene (HP:0100758)1.77678818
170Abnormality of T cell physiology (HP:0011840)1.77081803
171Stomach cancer (HP:0012126)1.76241040
172Leukopenia (HP:0001882)1.75874811
173Acanthosis nigricans (HP:0000956)1.75248396
174Purpura (HP:0000979)1.75063701
175Abnormal blistering of the skin (HP:0008066)1.74877764
176Lymphopenia (HP:0001888)1.74125163
177Sepsis (HP:0100806)1.72371633
178Vacuolated lymphocytes (HP:0001922)1.71826419
179Pulmonary infiltrates (HP:0002113)1.71277581
180Pigmentary retinal degeneration (HP:0001146)1.70846824
181Neonatal onset (HP:0003623)1.69017025
182Abnormality of serum amino acid levels (HP:0003112)1.68275674
183Hypoglycemic seizures (HP:0002173)1.67723713
184Abnormal gallbladder physiology (HP:0012438)1.66433418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.43992419
2TXK4.15607580
3TRIB33.98239257
4PRPF4B3.43709653
5SIK13.12051153
6FGFR42.86102119
7RIPK42.75765664
8BCKDK2.67811978
9PKN22.66795826
10MST1R2.43571816
11EPHB12.09193542
12PTK62.07531497
13RIPK11.97727754
14MAP4K11.91373599
15TYK21.84155952
16TAOK31.80117129
17TTN1.73266400
18TESK21.70076986
19EPHA21.65466756
20CAMK1D1.65193299
21LATS11.62332417
22IRAK41.58179894
23GRK61.50411046
24MAP3K101.50016875
25FRK1.44943281
26TNK21.42835467
27EEF2K1.42174855
28STK101.38047416
29TBK11.37664148
30SMG11.36700166
31JAK11.29663733
32MAP3K31.29401208
33BMX1.27696654
34TGFBR21.25800842
35LRRK21.23565710
36MET1.16095318
37CSK1.15276319
38MAP2K31.08731488
39IRAK31.08345551
40FGFR31.08270864
41JAK31.07097631
42MAP3K71.05241837
43PDGFRA1.05015930
44JAK21.04022451
45CAMK1G1.02684963
46MAP2K21.02591136
47FLT31.00977703
48BTK1.00936391
49ZAP701.00265922
50PTK20.99764368
51SYK0.97447606
52EPHA30.96893124
53MAPK110.96245161
54PRKD20.94017323
55MAP3K140.93761316
56FES0.91507606
57DDR20.91023948
58PRKAA20.90729635
59TESK10.88790028
60NEK90.86253702
61BLK0.85546650
62PRKG20.85200127
63ICK0.82818652
64CDK60.82667193
65CDC42BPA0.82463667
66MARK20.82221617
67IKBKE0.82181943
68ERBB40.80535186
69LCK0.80076440
70MAP3K110.79925657
71LYN0.79727328
72TAOK10.77988517
73TAOK20.77139476
74CDK120.76052899
75MST40.75888114
76ITK0.75655920
77MTOR0.75468607
78INSRR0.73396591
79DYRK1B0.73178655
80MAPK120.72028191
81PIK3CG0.70605481
82SIK30.70568769
83FGR0.69467021
84MAP3K60.69269015
85TRPM70.69014334
86CSF1R0.68584353
87MAP3K20.63474690
88PAK40.63030621
89KSR20.62913878
90PDPK10.62231858
91GSK3A0.61857123
92FER0.61361632
93STK30.59898670
94MAP3K10.57613288
95MATK0.57097521
96DMPK0.54862322
97CHUK0.54561741
98HCK0.53397247
99IRAK20.53152924
100MAPKAPK30.52827003
101FGFR20.52277527
102LMTK20.51187149
103PRKAA10.48569162
104IKBKB0.47546138
105FYN0.47412698
106PDGFRB0.46392944
107RET0.46112747
108MAP2K10.45489635
109MAPKAPK20.45364165
110KDR0.45149264
111PRKCH0.42129356
112MAP3K80.41815386
113PRKD10.41587592
114PIM10.41264497
115KIT0.40635229
116PAK20.40308191
117RPS6KL10.40089482
118RPS6KC10.40089482
119PIM20.39752214
120HIPK20.39657750
121PDK10.39538534
122RPS6KA20.39489818
123SGK30.38910322
124PIK3CA0.38233212
125YES10.38218051
126MAPK70.37981817
127EGFR0.37854213
128EPHB20.37797818
129SIK20.36865650
130RPS6KA40.36142029
131ERBB20.35193822
132IRAK10.34912876
133SGK10.34360095
134RPS6KA60.33980263
135FGFR10.33814473
136MAP3K130.33580694
137NLK0.33297862
138MAP2K60.31649691
139STK380.23631048

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31763069
2Nitrogen metabolism_Homo sapiens_hsa009102.95371413
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95321176
4Arginine biosynthesis_Homo sapiens_hsa002202.56586891
5Fatty acid degradation_Homo sapiens_hsa000712.56047889
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53293384
7Caffeine metabolism_Homo sapiens_hsa002322.39724462
8Tryptophan metabolism_Homo sapiens_hsa003802.36529132
9PPAR signaling pathway_Homo sapiens_hsa033202.28119244
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27760325
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23648351
12Complement and coagulation cascades_Homo sapiens_hsa046102.22608982
13Allograft rejection_Homo sapiens_hsa053302.11573229
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09689945
15Graft-versus-host disease_Homo sapiens_hsa053322.06680033
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06318371
17Fat digestion and absorption_Homo sapiens_hsa049752.05481630
18Staphylococcus aureus infection_Homo sapiens_hsa051502.05256163
19Autoimmune thyroid disease_Homo sapiens_hsa053202.01299426
20B cell receptor signaling pathway_Homo sapiens_hsa046621.92630676
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88294921
22Fatty acid metabolism_Homo sapiens_hsa012121.88049549
23Histidine metabolism_Homo sapiens_hsa003401.85113480
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83332862
25Propanoate metabolism_Homo sapiens_hsa006401.81517290
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81035615
27Peroxisome_Homo sapiens_hsa041461.70920446
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68933553
29Sulfur metabolism_Homo sapiens_hsa009201.68489482
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67746743
31Butanoate metabolism_Homo sapiens_hsa006501.65830053
32Tuberculosis_Homo sapiens_hsa051521.65183737
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63193497
34beta-Alanine metabolism_Homo sapiens_hsa004101.61343567
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57904694
36Chemical carcinogenesis_Homo sapiens_hsa052041.54261102
37Bile secretion_Homo sapiens_hsa049761.53177365
38Malaria_Homo sapiens_hsa051441.52874800
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48128287
40Starch and sucrose metabolism_Homo sapiens_hsa005001.45239637
41T cell receptor signaling pathway_Homo sapiens_hsa046601.43684140
42Type I diabetes mellitus_Homo sapiens_hsa049401.41295445
43Viral myocarditis_Homo sapiens_hsa054161.39117522
44ABC transporters_Homo sapiens_hsa020101.32957898
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.31092572
46Hematopoietic cell lineage_Homo sapiens_hsa046401.30425320
47Phenylalanine metabolism_Homo sapiens_hsa003601.28812965
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28506150
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.28336318
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26843064
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26840113
52Retinol metabolism_Homo sapiens_hsa008301.26659469
53Influenza A_Homo sapiens_hsa051641.24488464
54TNF signaling pathway_Homo sapiens_hsa046681.23962068
55Chemokine signaling pathway_Homo sapiens_hsa040621.22049639
56Antigen processing and presentation_Homo sapiens_hsa046121.21771721
57Selenocompound metabolism_Homo sapiens_hsa004501.21582054
58Folate biosynthesis_Homo sapiens_hsa007901.20842328
59Pyruvate metabolism_Homo sapiens_hsa006201.20369021
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19185108
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.17849127
62Carbon metabolism_Homo sapiens_hsa012001.17167271
63Vitamin digestion and absorption_Homo sapiens_hsa049771.16522079
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.15132055
65Non-small cell lung cancer_Homo sapiens_hsa052231.14559089
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14259943
67Glycerolipid metabolism_Homo sapiens_hsa005611.14045059
68Platelet activation_Homo sapiens_hsa046111.14003711
69VEGF signaling pathway_Homo sapiens_hsa043701.12541614
70Fatty acid biosynthesis_Homo sapiens_hsa000611.11815501
71Measles_Homo sapiens_hsa051621.11305573
72Primary immunodeficiency_Homo sapiens_hsa053401.10012000
73Asthma_Homo sapiens_hsa053101.09948741
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02660355
75Herpes simplex infection_Homo sapiens_hsa051681.02375492
76Tyrosine metabolism_Homo sapiens_hsa003501.00629235
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00013923
78Lysine degradation_Homo sapiens_hsa003100.98559071
79Biosynthesis of amino acids_Homo sapiens_hsa012300.98229183
80Phagosome_Homo sapiens_hsa041450.97212542
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.95842947
82Sulfur relay system_Homo sapiens_hsa041220.95762245
83Pancreatic cancer_Homo sapiens_hsa052120.94436866
84Notch signaling pathway_Homo sapiens_hsa043300.92451581
85GnRH signaling pathway_Homo sapiens_hsa049120.91660437
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.88097262
87Apoptosis_Homo sapiens_hsa042100.87039289
88Fatty acid elongation_Homo sapiens_hsa000620.86762331
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.86265163
90Hepatitis B_Homo sapiens_hsa051610.85579994
91Endocytosis_Homo sapiens_hsa041440.81775356
92Arginine and proline metabolism_Homo sapiens_hsa003300.81688230
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79323921
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.78968069
95Insulin resistance_Homo sapiens_hsa049310.78149554
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77667448
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77078822
98Pentose phosphate pathway_Homo sapiens_hsa000300.76438341
99Galactose metabolism_Homo sapiens_hsa000520.74330049
100Fructose and mannose metabolism_Homo sapiens_hsa000510.74055937
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.73445330
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.72813783
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72401008
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.72337374
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70899983
106Choline metabolism in cancer_Homo sapiens_hsa052310.69620178
107Glutathione metabolism_Homo sapiens_hsa004800.68667902
108Steroid biosynthesis_Homo sapiens_hsa001000.68075043
109Vitamin B6 metabolism_Homo sapiens_hsa007500.66149550
110African trypanosomiasis_Homo sapiens_hsa051430.64122063
111Legionellosis_Homo sapiens_hsa051340.63834877
112Prolactin signaling pathway_Homo sapiens_hsa049170.60615613
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56047335
114Rheumatoid arthritis_Homo sapiens_hsa053230.55415438
115Arachidonic acid metabolism_Homo sapiens_hsa005900.54839549
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54294647
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.53182560
118Endometrial cancer_Homo sapiens_hsa052130.52902572
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52601692
120Salmonella infection_Homo sapiens_hsa051320.52573147
121Renal cell carcinoma_Homo sapiens_hsa052110.51994658
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51485041
123Renin-angiotensin system_Homo sapiens_hsa046140.51345045
124Mineral absorption_Homo sapiens_hsa049780.51033214
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50666325
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50014157
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49397145
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49312448
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48661370
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47329141
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42376676
132Shigellosis_Homo sapiens_hsa051310.42329388
133Pancreatic secretion_Homo sapiens_hsa049720.41671657
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.41193497
135Estrogen signaling pathway_Homo sapiens_hsa049150.40837647
136Small cell lung cancer_Homo sapiens_hsa052220.40750191
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.40528525
138Lysosome_Homo sapiens_hsa041420.40112037
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39665583
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39400458
141AMPK signaling pathway_Homo sapiens_hsa041520.38560584
142Other glycan degradation_Homo sapiens_hsa005110.35496398
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35098639
144Linoleic acid metabolism_Homo sapiens_hsa005910.34618015
145Hepatitis C_Homo sapiens_hsa051600.32847512
146Bladder cancer_Homo sapiens_hsa052190.32596807
147Protein digestion and absorption_Homo sapiens_hsa049740.31621671
148Amoebiasis_Homo sapiens_hsa051460.31192759
149Acute myeloid leukemia_Homo sapiens_hsa052210.30304901
150Toxoplasmosis_Homo sapiens_hsa051450.24297749
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.23293801
152Insulin signaling pathway_Homo sapiens_hsa049100.22732181
153Metabolic pathways_Homo sapiens_hsa011000.21981601
154Prion diseases_Homo sapiens_hsa050200.20770758
155Leishmaniasis_Homo sapiens_hsa051400.20724561
156Osteoclast differentiation_Homo sapiens_hsa043800.19825673
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.19422779
158Pertussis_Homo sapiens_hsa051330.15975804
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15162738
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13789961
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11692128
162Glucagon signaling pathway_Homo sapiens_hsa049220.11261409
163Chronic myeloid leukemia_Homo sapiens_hsa052200.09892636

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