ZBTB7C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.16442266
2glomerular visceral epithelial cell development (GO:0072015)8.02926626
3glomerular epithelial cell development (GO:0072310)7.13101309
4cilium or flagellum-dependent cell motility (GO:0001539)6.91372535
5glomerular basement membrane development (GO:0032836)6.90362974
6cilium movement (GO:0003341)5.91216906
7motile cilium assembly (GO:0044458)5.76941925
8glomerulus development (GO:0032835)5.53262890
9hemidesmosome assembly (GO:0031581)5.20679272
10primary alcohol catabolic process (GO:0034310)5.07604138
11epithelial cilium movement (GO:0003351)5.01606583
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.86905584
13ethanol metabolic process (GO:0006067)4.59774205
14water homeostasis (GO:0030104)4.53020550
15desmosome organization (GO:0002934)4.31822401
16axoneme assembly (GO:0035082)3.98764466
17bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90527994
18one-carbon compound transport (GO:0019755)3.87957100
19keratinocyte differentiation (GO:0030216)3.76722176
20kidney mesenchyme development (GO:0072074)3.69892976
21establishment of tissue polarity (GO:0007164)3.68399569
22establishment of planar polarity (GO:0001736)3.68399569
23left/right pattern formation (GO:0060972)3.67411271
24metanephric mesenchyme development (GO:0072075)3.63513658
25protein heterotrimerization (GO:0070208)3.60786180
26vitamin transmembrane transport (GO:0035461)3.58049403
27diterpenoid biosynthetic process (GO:0016102)3.45703908
28ethanol oxidation (GO:0006069)3.44357023
29keratinocyte proliferation (GO:0043616)3.41267265
30outer ear morphogenesis (GO:0042473)3.37378876
31positive regulation of p38MAPK cascade (GO:1900745)3.36391861
32lung epithelium development (GO:0060428)3.35683801
33pyrimidine-containing compound transmembrane transport (GO:0072531)3.32330700
34regulation of glomerular filtration (GO:0003093)3.24818127
35sperm capacitation (GO:0048240)3.23321566
36paraxial mesoderm development (GO:0048339)3.23227868
37sodium ion homeostasis (GO:0055078)3.21387813
38epidermal cell differentiation (GO:0009913)3.15828124
39thyroid hormone generation (GO:0006590)3.14021789
40epidermis development (GO:0008544)3.11910786
41microtubule bundle formation (GO:0001578)3.05251154
42lateral sprouting from an epithelium (GO:0060601)3.04922957
43basement membrane organization (GO:0071711)3.02697670
44atrioventricular valve morphogenesis (GO:0003181)2.97637199
45apical protein localization (GO:0045176)2.94650677
46diaphragm development (GO:0060539)2.94174170
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.93429436
48collagen fibril organization (GO:0030199)2.90996014
49gastrulation with mouth forming second (GO:0001702)2.90341040
50negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.90172024
51glucocorticoid biosynthetic process (GO:0006704)2.88219660
52cell migration involved in sprouting angiogenesis (GO:0002042)2.88111157
53thyroid hormone metabolic process (GO:0042403)2.88015691
54epithelial cell-cell adhesion (GO:0090136)2.87061900
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86560794
56skeletal muscle organ development (GO:0060538)2.86254543
57phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.85059189
58mesenchymal to epithelial transition (GO:0060231)2.84723999
59positive regulation of mesonephros development (GO:0061213)2.84382990
60regulation of female gonad development (GO:2000194)2.83948644
61embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83851183
62long-chain fatty acid biosynthetic process (GO:0042759)2.81013552
63regulation of water loss via skin (GO:0033561)2.80955767
64regulation of axon guidance (GO:1902667)2.79854594
65retinoic acid metabolic process (GO:0042573)2.79832258
66planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79830870
67epithelial cell differentiation involved in kidney development (GO:0035850)2.79210642
68myoblast fusion (GO:0007520)2.78845848
69establishment of skin barrier (GO:0061436)2.78646570
70ventricular cardiac muscle cell action potential (GO:0086005)2.77411964
71renal system process involved in regulation of blood volume (GO:0001977)2.77235932
72regulation of mesonephros development (GO:0061217)2.75776818
73regulation of p38MAPK cascade (GO:1900744)2.74992574
74intermediate filament organization (GO:0045109)2.74979456
75O-glycan processing (GO:0016266)2.74910337
76positive regulation of digestive system process (GO:0060456)2.73839032
77excretion (GO:0007588)2.72914173
78polarized epithelial cell differentiation (GO:0030859)2.72809727
79primary alcohol metabolic process (GO:0034308)2.72135900
80flavonoid metabolic process (GO:0009812)2.69853504
81positive regulation of catenin import into nucleus (GO:0035413)2.69181047
82regulation of cardioblast differentiation (GO:0051890)2.68874189
83branching involved in salivary gland morphogenesis (GO:0060445)2.68394993
84calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.65628432
85regulation of cell fate specification (GO:0042659)2.64740250
86cell adhesion mediated by integrin (GO:0033627)2.64450770
87molting cycle (GO:0042303)2.61467830
88hair cycle (GO:0042633)2.61467830
89plasma membrane repair (GO:0001778)2.61015447
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59199740
91retinol metabolic process (GO:0042572)2.58153042
92cellular response to vitamin D (GO:0071305)2.57597120
93lipoxygenase pathway (GO:0019372)2.57364323
94hippo signaling (GO:0035329)2.57161507
95regulation of axon extension involved in axon guidance (GO:0048841)2.56868161
96axon extension involved in axon guidance (GO:0048846)2.56496912
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.56496912
98cardiac muscle cell proliferation (GO:0060038)2.56221238
99regulation of glomerulus development (GO:0090192)2.56038998
100body morphogenesis (GO:0010171)2.55791908
101ureteric bud development (GO:0001657)2.55577783
102embryonic camera-type eye development (GO:0031076)2.54751350
103vascular endothelial growth factor signaling pathway (GO:0038084)2.53813658
104regulation of male gonad development (GO:2000018)2.53805678
105mesonephric tubule development (GO:0072164)2.53681294
106cochlea development (GO:0090102)2.51994813
107negative regulation of fatty acid transport (GO:2000192)2.50437826
108syncytium formation by plasma membrane fusion (GO:0000768)2.50292463
109mesonephric epithelium development (GO:0072163)2.49970938
110polyol transport (GO:0015791)2.48675493
111interferon-gamma secretion (GO:0072643)2.48127577
112notochord development (GO:0030903)2.46422699
113negative regulation of T cell differentiation in thymus (GO:0033085)2.45827846
114positive regulation of kidney development (GO:0090184)2.45213980
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.45180163
116negative regulation of keratinocyte proliferation (GO:0010839)2.44798903
117lymph vessel development (GO:0001945)2.44588034
118keratinization (GO:0031424)2.44112918
119terpenoid biosynthetic process (GO:0016114)2.43394400
120regulation of catenin import into nucleus (GO:0035412)2.42687735
121lung vasculature development (GO:0060426)2.42331400
122head development (GO:0060322)2.42091948
123regulation of mesenchymal cell apoptotic process (GO:2001053)2.41220530
124phosphatidylserine acyl-chain remodeling (GO:0036150)2.40448678
125positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.39824957
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39199548
127endocardial cushion morphogenesis (GO:0003203)2.39155307
128skin morphogenesis (GO:0043589)2.38841872
129lymphangiogenesis (GO:0001946)2.38221442
130regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.38146677
131negative regulation of chondrocyte differentiation (GO:0032331)2.38111016
132ovulation cycle (GO:0042698)2.37587069
133negative regulation of axon guidance (GO:1902668)2.37075000
134renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.36969074
135ganglion development (GO:0061548)2.36587549
136sulfate transmembrane transport (GO:1902358)2.36505572
137androgen biosynthetic process (GO:0006702)2.36115965
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35724098
139establishment or maintenance of bipolar cell polarity (GO:0061245)2.35437385
140establishment or maintenance of apical/basal cell polarity (GO:0035088)2.35437385
141regulation of cilium movement (GO:0003352)2.34278529
142syncytium formation (GO:0006949)2.34155634
143organ induction (GO:0001759)2.32860215
144positive regulation of metanephros development (GO:0072216)2.32640859
145intestinal epithelial cell development (GO:0060576)2.32168765
146embryonic body morphogenesis (GO:0010172)2.31279927
147muscle cell fate commitment (GO:0042693)2.30047240
148peptide cross-linking (GO:0018149)2.29900108
149cellular response to gonadotropin stimulus (GO:0071371)2.29652518
150asymmetric protein localization (GO:0008105)2.29592405
151cell-substrate junction assembly (GO:0007044)2.29317771
152negative regulation of catenin import into nucleus (GO:0035414)2.28993346
153regulation of heart morphogenesis (GO:2000826)2.28824174
154skin development (GO:0043588)2.28787333
155keratinocyte development (GO:0003334)2.28684607
156amyloid precursor protein catabolic process (GO:0042987)2.27843574
157proximal/distal pattern formation (GO:0009954)2.27828810
158negative regulation of cell fate specification (GO:0009996)2.27644654
159regulation of heart rate by cardiac conduction (GO:0086091)2.27096587
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26464465
161multicellular organismal water homeostasis (GO:0050891)2.25613422
162negative regulation of cell fate commitment (GO:0010454)2.25295732
163regulation of cardioblast proliferation (GO:0003264)2.24711796
164regulation of secondary heart field cardioblast proliferation (GO:0003266)2.24711796
165cilium organization (GO:0044782)2.24327450
166camera-type eye morphogenesis (GO:0048593)2.23980304
167cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.23383678
168regulation of cell proliferation involved in kidney development (GO:1901722)2.23215189
169surfactant homeostasis (GO:0043129)2.22110252
170cilium assembly (GO:0042384)2.21469708
171negative regulation of protein localization to cell surface (GO:2000009)2.20795015
172establishment or maintenance of monopolar cell polarity (GO:0061339)2.20203024
173establishment of monopolar cell polarity (GO:0061162)2.20203024
174endothelial cell chemotaxis (GO:0035767)2.17316411
175left/right axis specification (GO:0070986)2.16844784
176cellular sodium ion homeostasis (GO:0006883)2.15778722
177cell-cell junction maintenance (GO:0045217)2.15652206
178intermediate filament cytoskeleton organization (GO:0045104)2.14167850
179cell junction maintenance (GO:0034331)2.13964262
180ventricular system development (GO:0021591)2.13232624
181specification of organ identity (GO:0010092)2.13099900
182ear development (GO:0043583)2.11314973
183establishment of apical/basal cell polarity (GO:0035089)2.11114189
184water transport (GO:0006833)2.10895804
185chemical homeostasis within a tissue (GO:0048875)2.10256014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.36558571
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.53282531
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.55797442
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47914927
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.16287779
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09911963
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04582811
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99005369
9EED_16625203_ChIP-ChIP_MESCs_Mouse1.98408376
10EZH2_27304074_Chip-Seq_ESCs_Mouse1.92299506
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92238498
12EZH2_22144423_ChIP-Seq_EOC_Human1.89634498
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89483242
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89483242
15* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89178303
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87692968
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86310529
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.83351855
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81322990
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80081051
21CLOCK_20551151_ChIP-Seq_293T_Human1.73942328
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73128747
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.72696974
24* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71841311
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.68356341
26* TP53_20018659_ChIP-ChIP_R1E_Mouse1.67098366
27* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65062929
28* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64416162
29* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57766921
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.55224835
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.53831044
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52434377
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52139846
34AHR_22903824_ChIP-Seq_MCF-7_Human1.50990992
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49875820
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49680515
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49414976
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46430487
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46430487
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46430487
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46293231
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45784407
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45748486
44* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44918688
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41190813
46* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38667611
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35283984
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33333126
49TP53_18474530_ChIP-ChIP_U2OS_Human1.32958998
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31994844
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.30392717
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30123040
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26394623
54TP63_22573176_ChIP-Seq_HFKS_Human1.26210862
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25937776
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.25213931
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25151450
58CJUN_26792858_Chip-Seq_BT549_Human1.24918015
59TP63_23658742_ChIP-Seq_EP156T_Human1.23933382
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22789344
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22777009
62AR_21572438_ChIP-Seq_LNCaP_Human1.22753936
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21930390
64KDM2B_26808549_Chip-Seq_K562_Human1.21693533
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.19530339
66TP53_16413492_ChIP-PET_HCT116_Human1.18679919
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.18370184
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.18094416
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17636306
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15151181
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.15038856
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14541834
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14396481
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12907196
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12219049
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11305011
77* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11144479
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.10519026
79* SOX2_20726797_ChIP-Seq_SW620_Human1.10349242
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10169856
81* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10065011
82GATA4_25053715_ChIP-Seq_YYC3_Human1.07904914
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07892868
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07515052
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06632514
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06450583
87BCAT_22108803_ChIP-Seq_LS180_Human1.06033718
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.05790127
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.05664782
90* RXR_22108803_ChIP-Seq_LS180_Human1.03534316
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02257886
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01335325
93RACK7_27058665_Chip-Seq_MCF-7_Human1.01205610
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.99318022
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.99197861
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98720195
97KLF5_25053715_ChIP-Seq_YYC3_Human0.98333140
98SMC4_20622854_ChIP-Seq_HELA_Human0.97880507
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97040142
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96460713
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95559320
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94925780
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94925780
104GATA3_24758297_ChIP-Seq_MCF-7_Human0.92699409
105CTCF_27219007_Chip-Seq_Bcells_Human0.91858391
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91427607
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90899722
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90879583
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90707594
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.90519552
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90015913
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89014917
113BRD4_25478319_ChIP-Seq_HGPS_Human0.88261329
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88137799
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88124414
116DROSHA_22980978_ChIP-Seq_HELA_Human0.87669406
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86919835
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86541073
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86266936
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86131853
121REST_21632747_ChIP-Seq_MESCs_Mouse0.85201032
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84073969
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83656085
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83440914
125ZNF263_19887448_ChIP-Seq_K562_Human0.83168747
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83062153
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82787219
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.82635816
129AR_19668381_ChIP-Seq_PC3_Human0.81454900
130* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80766799
131GATA6_25053715_ChIP-Seq_YYC3_Human0.80243137
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79852774
133SMAD4_21799915_ChIP-Seq_A2780_Human0.79747655
134LXR_22292898_ChIP-Seq_THP-1_Human0.79421422
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79381000
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79111596
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79026014
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78566840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.58426194
2MP0004043_abnormal_pH_regulation3.75666928
3MP0004272_abnormal_basement_membrane3.50664611
4MP0005275_abnormal_skin_tensile3.13652767
5MP0002254_reproductive_system_inflammat2.86295453
6MP0008875_abnormal_xenobiotic_pharmacok2.73536986
7MP0003878_abnormal_ear_physiology2.70212219
8MP0005377_hearing/vestibular/ear_phenot2.70212219
9MP0005623_abnormal_meninges_morphology2.68087921
10MP0003705_abnormal_hypodermis_morpholog2.64902419
11MP0000566_synostosis2.57366291
12MP0005503_abnormal_tendon_morphology2.55677550
13MP0000579_abnormal_nail_morphology2.47950179
14MP0009379_abnormal_foot_pigmentation2.43591748
15MP0002796_impaired_skin_barrier2.38509517
16MP0001346_abnormal_lacrimal_gland2.27575025
17MP0000678_abnormal_parathyroid_gland2.16652934
18MP0000467_abnormal_esophagus_morphology2.14114441
19MP0008438_abnormal_cutaneous_collagen2.08481023
20MP0010030_abnormal_orbit_morphology2.05129347
21MP0000762_abnormal_tongue_morphology2.00210913
22MP0001984_abnormal_olfaction1.98638553
23MP0002060_abnormal_skin_morphology1.94129879
24MP0004264_abnormal_extraembryonic_tissu1.93725586
25MP0002249_abnormal_larynx_morphology1.92571829
26MP0003942_abnormal_urinary_system1.90913803
27MP0002653_abnormal_ependyma_morphology1.88791592
28MP0009053_abnormal_anal_canal1.85056673
29MP0000534_abnormal_ureter_morphology1.84675272
30MP0000537_abnormal_urethra_morphology1.83899041
31MP0001849_ear_inflammation1.78754163
32MP0003566_abnormal_cell_adhesion1.75695795
33MP0008004_abnormal_stomach_pH1.71638412
34MP0001765_abnormal_ion_homeostasis1.70695075
35MP0004185_abnormal_adipocyte_glucose1.69732649
36MP0009250_abnormal_appendicular_skeleto1.69077085
37MP0001485_abnormal_pinna_reflex1.65960286
38MP0002233_abnormal_nose_morphology1.63497719
39MP0003385_abnormal_body_wall1.63348299
40MP0005409_darkened_coat_color1.61720908
41MP0002098_abnormal_vibrissa_morphology1.61396783
42MP0010234_abnormal_vibrissa_follicle1.61083450
43MP0002896_abnormal_bone_mineralization1.56994936
44MP0002877_abnormal_melanocyte_morpholog1.56651283
45MP0004782_abnormal_surfactant_physiolog1.56356387
46MP0009384_cardiac_valve_regurgitation1.54938383
47MP0000377_abnormal_hair_follicle1.53365275
48MP0000049_abnormal_middle_ear1.49624451
49MP0002282_abnormal_trachea_morphology1.44418195
50MP0000516_abnormal_urinary_system1.43171464
51MP0005367_renal/urinary_system_phenotyp1.43171464
52MP0005501_abnormal_skin_physiology1.37930346
53MP0005508_abnormal_skeleton_morphology1.37291882
54MP0003937_abnormal_limbs/digits/tail_de1.37048493
55MP0005257_abnormal_intraocular_pressure1.36588717
56MP0000538_abnormal_urinary_bladder1.36414218
57MP0004019_abnormal_vitamin_homeostasis1.35512347
58MP0003119_abnormal_digestive_system1.32788079
59MP0003283_abnormal_digestive_organ1.31267839
60MP0002876_abnormal_thyroid_physiology1.28438072
61MP0002234_abnormal_pharynx_morphology1.28053031
62MP0003755_abnormal_palate_morphology1.26929981
63MP0010368_abnormal_lymphatic_system1.26334176
64MP0005394_taste/olfaction_phenotype1.24495022
65MP0005499_abnormal_olfactory_system1.24495022
66MP0000462_abnormal_digestive_system1.23419109
67MP0000383_abnormal_hair_follicle1.19542680
68MP0003122_maternal_imprinting1.19002165
69MP0003329_amyloid_beta_deposits1.17927168
70MP0000163_abnormal_cartilage_morphology1.14016980
71MP0010678_abnormal_skin_adnexa1.13448210
72MP0009780_abnormal_chondrocyte_physiolo1.13137190
73MP0010386_abnormal_urinary_bladder1.12865847
74MP0002108_abnormal_muscle_morphology1.11693742
75MP0006072_abnormal_retinal_apoptosis1.10957299
76MP0003453_abnormal_keratinocyte_physiol1.10891561
77MP0000465_gastrointestinal_hemorrhage1.09301622
78MP0000613_abnormal_salivary_gland1.09293936
79MP0000681_abnormal_thyroid_gland1.08956788
80MP0001188_hyperpigmentation1.07982422
81MP0005248_abnormal_Harderian_gland1.07451282
82MP0003879_abnormal_hair_cell1.07418167
83MP0010771_integument_phenotype1.07044433
84MP0000751_myopathy1.06452291
85MP0000647_abnormal_sebaceous_gland1.06269930
86MP0002932_abnormal_joint_morphology1.05139229
87MP0002735_abnormal_chemical_nociception1.04344592
88MP0003279_aneurysm1.02666421
89MP0003935_abnormal_craniofacial_develop1.01648950
90MP0001216_abnormal_epidermal_layer1.01589715
91MP0002116_abnormal_craniofacial_bone0.99506793
92MP0001501_abnormal_sleep_pattern0.99455602
93MP0001986_abnormal_taste_sensitivity0.97923059
94MP0000026_abnormal_inner_ear0.96936070
95MP0002132_abnormal_respiratory_system0.96290892
96MP0005083_abnormal_biliary_tract0.96234488
97MP0008789_abnormal_olfactory_epithelium0.92466461
98MP0002697_abnormal_eye_size0.91403215
99MP0003011_delayed_dark_adaptation0.91388023
100MP0002177_abnormal_outer_ear0.90671392
101MP0001756_abnormal_urination0.90601213
102MP0004133_heterotaxia0.90327218
103MP0002295_abnormal_pulmonary_circulatio0.90134683
104MP0000013_abnormal_adipose_tissue0.89757364
105MP0004233_abnormal_muscle_weight0.89013752
106MP0004858_abnormal_nervous_system0.88208485
107MP0004947_skin_inflammation0.88041602
108MP0004885_abnormal_endolymph0.87548609
109MP0005365_abnormal_bile_salt0.87314687
110MP0000427_abnormal_hair_cycle0.87053378
111MP0010352_gastrointestinal_tract_polyps0.86801052
112MP0001879_abnormal_lymphatic_vessel0.85603355
113MP0002115_abnormal_skeleton_extremities0.85383176
114MP0002109_abnormal_limb_morphology0.84511243
115MP0000428_abnormal_craniofacial_morphol0.83481897
116MP0003091_abnormal_cell_migration0.82600875
117MP0001502_abnormal_circadian_rhythm0.82452447
118MP0004859_abnormal_synaptic_plasticity0.80843809
119MP0001299_abnormal_eye_distance/0.80746942
120MP0002734_abnormal_mechanical_nocicepti0.80163558
121MP0005187_abnormal_penis_morphology0.78872754
122MP0005666_abnormal_adipose_tissue0.78537782
123MP0003045_fibrosis0.78230642
124MP0001664_abnormal_digestion0.78196281
125MP0002837_dystrophic_cardiac_calcinosis0.78074720
126MP0000432_abnormal_head_morphology0.75709398
127MP0002909_abnormal_adrenal_gland0.74804831
128MP0005023_abnormal_wound_healing0.73894888
129MP0004381_abnormal_hair_follicle0.73328910
130MP0002168_other_aberrant_phenotype0.72950414
131MP0003115_abnormal_respiratory_system0.72235274
132MP0005636_abnormal_mineral_homeostasis0.71030400
133MP0005076_abnormal_cell_differentiation0.70757894
134MP0002139_abnormal_hepatobiliary_system0.70122407
135MP0006138_congestive_heart_failure0.69774963
136MP0009931_abnormal_skin_appearance0.69698511
137MP0000470_abnormal_stomach_morphology0.69445203
138MP0001963_abnormal_hearing_physiology0.69281560
139MP0000778_abnormal_nervous_system0.68852885
140MP0008961_abnormal_basal_metabolism0.68674412
141MP0002111_abnormal_tail_morphology0.68453096
142MP0001340_abnormal_eyelid_morphology0.68147593
143MP0002277_abnormal_respiratory_mucosa0.66714261
144MP0002114_abnormal_axial_skeleton0.65426635
145MP0009643_abnormal_urine_homeostasis0.65137590
146MP0003191_abnormal_cellular_cholesterol0.64845616
147MP0003938_abnormal_ear_development0.64671743
148MP0004742_abnormal_vestibular_system0.63862986
149MP0005085_abnormal_gallbladder_physiolo0.63059559
150MP0002822_catalepsy0.62784150
151MP0005646_abnormal_pituitary_gland0.62550839
152MP0000367_abnormal_coat/_hair0.62254036
153MP0002136_abnormal_kidney_physiology0.61785004
154MP0005670_abnormal_white_adipose0.57832557
155MP0002572_abnormal_emotion/affect_behav0.55801286
156MP0005647_abnormal_sex_gland0.55046286
157MP0003890_abnormal_embryonic-extraembry0.54052723
158MP0002089_abnormal_postnatal_growth/wei0.53615862

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.77105137
2Abnormal respiratory motile cilium physiology (HP:0012261)6.64572532
3Abnormal respiratory motile cilium morphology (HP:0005938)6.45176085
4Abnormal respiratory epithelium morphology (HP:0012253)6.45176085
5Abnormal ciliary motility (HP:0012262)6.34610823
6Rhinitis (HP:0012384)6.31915169
7Absent/shortened dynein arms (HP:0200106)6.15116715
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.15116715
9Chronic bronchitis (HP:0004469)6.00818190
10Hyperactive renin-angiotensin system (HP:0000841)5.48460481
11Decreased circulating renin level (HP:0003351)4.94153414
12Bronchiectasis (HP:0002110)4.41814772
13Mesangial abnormality (HP:0001966)4.29294885
14Nasal polyposis (HP:0100582)4.07379441
15Right ventricular cardiomyopathy (HP:0011663)4.04844133
16Focal segmental glomerulosclerosis (HP:0000097)3.84466220
17Abnormality of renin-angiotensin system (HP:0000847)3.77486259
18Pterygium (HP:0001059)3.76772300
19Abnormality of the nasal mucosa (HP:0000433)3.64606822
20Popliteal pterygium (HP:0009756)3.62293849
21Hyperaldosteronism (HP:0000859)3.61320016
22Atrophic scars (HP:0001075)3.55030549
23Abnormality of nail color (HP:0100643)3.48617262
24Premature rupture of membranes (HP:0001788)3.32253700
25Fragile nails (HP:0001808)3.22428295
26Lip pit (HP:0100267)3.14628694
27Hyperkalemia (HP:0002153)3.11282644
28Abnormal pancreas size (HP:0012094)3.10833766
29Male infertility (HP:0003251)3.10504325
30Hepatoblastoma (HP:0002884)3.05690173
31Renal salt wasting (HP:0000127)3.03586903
32Protrusio acetabuli (HP:0003179)3.03165965
33Glomerulosclerosis (HP:0000096)2.97527850
34Milia (HP:0001056)2.95707342
35Infertility (HP:0000789)2.91329985
36Fragile skin (HP:0001030)2.85353857
37Abnormality of chloride homeostasis (HP:0011422)2.78181219
38Hypoalbuminemia (HP:0003073)2.75780177
39Abnormal albumin level (HP:0012116)2.75780177
40Congenital ichthyosiform erythroderma (HP:0007431)2.75090831
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.75002973
42Shallow orbits (HP:0000586)2.74826379
43Erythroderma (HP:0001019)2.74803517
44Bronchitis (HP:0012387)2.73761195
45Advanced eruption of teeth (HP:0006288)2.72563200
46Woolly hair (HP:0002224)2.71484738
47Overgrowth (HP:0001548)2.71178534
48Increased IgE level (HP:0003212)2.70426422
49Abnormality of calcium-phosphate metabolism (HP:0100530)2.68838324
50Follicular hyperkeratosis (HP:0007502)2.67865551
51Abnormal hair laboratory examination (HP:0003328)2.67657040
52Bronchomalacia (HP:0002780)2.67374678
53Abnormality of secondary sexual hair (HP:0009888)2.66710086
54Abnormality of the axillary hair (HP:0100134)2.66710086
55Hyponatremia (HP:0002902)2.63051532
56Plantar hyperkeratosis (HP:0007556)2.55422904
57Corneal erosion (HP:0200020)2.54612103
58Aplasia involving bones of the upper limbs (HP:0009823)2.51448773
59Aplasia of the phalanges of the hand (HP:0009802)2.51448773
60Aplasia involving bones of the extremities (HP:0009825)2.51448773
61Abnormality of sodium homeostasis (HP:0010931)2.49361596
62Increased connective tissue (HP:0009025)2.47220436
63Down-sloping shoulders (HP:0200021)2.44584805
64Ankle contracture (HP:0006466)2.42508889
65Morphological abnormality of the middle ear (HP:0008609)2.37323123
66Onycholysis (HP:0001806)2.34809600
67True hermaphroditism (HP:0010459)2.34734815
68Hypotrichosis (HP:0001006)2.34585113
69Recurrent otitis media (HP:0000403)2.34216270
70Abnormality of permanent molar morphology (HP:0011071)2.31870328
71Abnormality of the dental root (HP:0006486)2.31870328
72Taurodontia (HP:0000679)2.31870328
73Oligodontia (HP:0000677)2.27826578
74Germ cell neoplasia (HP:0100728)2.26569163
75Abnormality of dentin (HP:0010299)2.23840841
76Flat acetabular roof (HP:0003180)2.23508885
77Natal tooth (HP:0000695)2.19757838
78Recurrent sinusitis (HP:0011108)2.18155532
79Distal lower limb muscle weakness (HP:0009053)2.15495459
80Adrenal overactivity (HP:0002717)2.15080811
81Alopecia of scalp (HP:0002293)2.14355183
82Type 1 muscle fiber predominance (HP:0003803)2.14327290
83Erythema (HP:0010783)2.13750409
84Abnormality of molar morphology (HP:0011070)2.12780226
85Abnormality of molar (HP:0011077)2.12780226
86Occipital encephalocele (HP:0002085)2.10922342
87Aplasia of the musculature (HP:0100854)2.10153850
88Broad metatarsal (HP:0001783)2.08927289
89Abnormality of the dental pulp (HP:0006479)2.08080639
90Abnormality of the middle phalanges of the toes (HP:0010183)2.07935917
91Thin bony cortex (HP:0002753)2.07183962
92Stage 5 chronic kidney disease (HP:0003774)2.06311642
93Mildly elevated creatine phosphokinase (HP:0008180)2.05905420
94Atelectasis (HP:0100750)2.05088094
95Chronic sinusitis (HP:0011109)2.04456469
96Thick nail (HP:0001805)2.02610425
97Abnormality of the salivary glands (HP:0010286)2.01760839
98Fibular aplasia (HP:0002990)2.01202194
99Ridged nail (HP:0001807)2.01199798
100Distal lower limb amyotrophy (HP:0008944)2.00635714
101Coronal craniosynostosis (HP:0004440)2.00045229
102Spinal cord compression (HP:0002176)1.99299151
103Palmoplantar hyperkeratosis (HP:0000972)1.98059145
104Tibial bowing (HP:0002982)1.97999657
105Neonatal short-limb short stature (HP:0008921)1.96160914
106Hyperparathyroidism (HP:0000843)1.93936024
107Tubulointerstitial nephritis (HP:0001970)1.93669997
108Palmar hyperkeratosis (HP:0010765)1.93053686
109Alkalosis (HP:0001948)1.91922978
110Cutaneous finger syndactyly (HP:0010554)1.87591182
111Dehydration (HP:0001944)1.87248684
112Syncope (HP:0001279)1.86457600
113Abnormality of potassium homeostasis (HP:0011042)1.85350988
114Chronic hepatic failure (HP:0100626)1.84326771
115Obstructive sleep apnea (HP:0002870)1.83753508
116Aplasia cutis congenita (HP:0001057)1.81273421
117Abnormality of the labia majora (HP:0012881)1.80909576
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79964163
119Hypoplastic labia majora (HP:0000059)1.79466184
120Short hallux (HP:0010109)1.77890158
121Lower limb amyotrophy (HP:0007210)1.76034217
122Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.75894141
123Furrowed tongue (HP:0000221)1.75313708
124Spinal rigidity (HP:0003306)1.74369883
125Neoplasm of the adrenal cortex (HP:0100641)1.73923960
126Femoral bowing (HP:0002980)1.72639319
127Tubular atrophy (HP:0000092)1.72118705
128Ventricular tachycardia (HP:0004756)1.71367101
129Hyporeflexia of lower limbs (HP:0002600)1.71182891
130Hypoplastic ischia (HP:0003175)1.70772809
131Male pseudohermaphroditism (HP:0000037)1.70042561
132Sparse scalp hair (HP:0002209)1.69689829
133Abnormality of hair growth rate (HP:0011363)1.69455453
134Slow-growing hair (HP:0002217)1.69455453
135Testicular neoplasm (HP:0010788)1.69051021
136Hip contracture (HP:0003273)1.68933475
137Malnutrition (HP:0004395)1.68892661
138Hyperglycemia (HP:0003074)1.68592398
139Absent eyelashes (HP:0000561)1.68136480
140Ventricular fibrillation (HP:0001663)1.67666161
141Hypoplastic toenails (HP:0001800)1.66751484
142Nephritis (HP:0000123)1.66405296
143Hypokalemic alkalosis (HP:0001949)1.65994072
144Hypokalemia (HP:0002900)1.65650187
145Metabolic alkalosis (HP:0200114)1.65334413
146Soft skin (HP:0000977)1.65092452
147Lymphangioma (HP:0100764)1.64907028
148Upper limb muscle weakness (HP:0003484)1.64803852
149Turricephaly (HP:0000262)1.63751450
150Venous abnormality (HP:0002624)1.63597969
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63395344
152Bladder diverticulum (HP:0000015)1.62556197
153Pili torti (HP:0003777)1.62520691
154Enlarged penis (HP:0000040)1.62182553
155Tarsal synostosis (HP:0008368)1.61967400
156Fatigable weakness (HP:0003473)1.61863771
157Abnormality of the neuromuscular junction (HP:0003398)1.61863771
158Limited hip movement (HP:0008800)1.61755901
159Hypoplasia of dental enamel (HP:0006297)1.61623813
160Wormian bones (HP:0002645)1.61574724
161Venous insufficiency (HP:0005293)1.61380528
162Abnormal vertebral ossification (HP:0100569)1.61336575
163Pancreatic fibrosis (HP:0100732)1.61185149
164Cystic liver disease (HP:0006706)1.60867765
165Short nail (HP:0001799)1.60422990
166Hypoplasia of the uterus (HP:0000013)1.59809663
167Cerebral aneurysm (HP:0004944)1.59177685
168Abnormality of the ischium (HP:0003174)1.58474904
169Radial bowing (HP:0002986)1.58369551
170Dysmetric saccades (HP:0000641)1.58228407
171Abnormality of the distal phalanges of the toes (HP:0010182)1.58218408
172Shawl scrotum (HP:0000049)1.56450416
173Hyperextensible skin (HP:0000974)1.55911465
174Hypohidrosis (HP:0000966)1.55717107
175Humeroradial synostosis (HP:0003041)1.55502528
176Sparse eyelashes (HP:0000653)1.54267260
177Bell-shaped thorax (HP:0001591)1.52282208
178Diaphragmatic weakness (HP:0009113)1.51122858
179Nephronophthisis (HP:0000090)1.51010274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.11730100
2MAPK153.17230388
3LATS13.09017566
4CASK2.97411940
5EPHA22.77520446
6LATS22.70624886
7MST1R2.59707967
8FER2.56089829
9TRIB32.48133542
10WNK42.26219074
11DDR22.16024370
12EPHA32.11360139
13LMTK22.09066103
14PDGFRA2.01745310
15OXSR11.99062723
16MST41.96925290
17MAP3K21.95408899
18ERBB41.85343279
19RIPK11.67410515
20MET1.65744177
21NEK61.65224142
22MAP3K61.61696468
23PTK21.54333450
24PAK31.54239016
25NTRK21.53052640
26SIK11.42958027
27MAP3K31.40591805
28WNK31.40553382
29PKN21.38611392
30FRK1.37606478
31BMX1.32416961
32SGK2231.32393871
33SGK4941.32393871
34MAP3K91.28030372
35PIK3CA1.25581532
36PRKG21.25308495
37FGFR41.23019605
38MAP2K11.20048920
39MARK11.19378618
40INSRR1.17746788
41PTK61.17343902
42STK38L1.17001159
43SGK21.16293072
44DYRK1B1.09094370
45ROCK11.05881872
46STK381.04180186
47MAP2K21.03113066
48ACVR1B1.01441557
49TTN1.00366783
50TAOK11.00087636
51MYLK0.96119984
52MAPKAPK30.94836584
53EPHA40.94417870
54PRPF4B0.92362790
55PAK40.92064363
56CDC42BPA0.91539713
57NTRK10.89732608
58CAMK1G0.89411712
59ERBB20.89207513
60MKNK20.88901414
61RET0.88883942
62HIPK20.86938540
63AKT30.86222548
64EPHB10.85062195
65PNCK0.84811108
66NTRK30.84614106
67PAK20.83060786
68PRKAA20.81982978
69PRKCI0.79569031
70PRKD30.78948822
71FGFR10.77901124
72MAP3K70.77027539
73MTOR0.76088091
74SGK30.75872789
75PIK3CG0.75814216
76ERBB30.75424322
77MAP3K40.74991589
78SMG10.73900071
79CAMK1D0.73369504
80NME10.71804815
81ERN10.70201004
82MAP2K40.68434537
83DYRK1A0.67746023
84MAPKAPK50.65853886
85PDGFRB0.65120842
86TGFBR10.64862799
87CAMKK10.64148332
88CAMK2B0.63530112
89LIMK10.63457435
90CDK120.63186221
91SGK10.63115495
92GSK3A0.62245212
93STK240.60876304
94PHKG20.60522366
95PHKG10.60522366
96TYRO30.59393963
97PDPK10.58603257
98PRKCE0.58514750
99RPS6KB20.58019577
100CDK190.57946959
101MARK20.57540493
102RPS6KA20.56830836
103FGFR20.56402332
104PRKAA10.55505446
105PRKCZ0.55345732
106UHMK10.55144942
107TRPM70.55021407
108MAPK130.54106607
109MAP2K60.52743350
110CDK50.51282899
111MAPK120.51243562
112ALK0.51123900
113ROCK20.50024159
114MAP2K70.49877449
115GRK10.49183868
116PAK60.47960394
117MINK10.47332737
118ADRBK10.47033220
119DMPK0.46578834
120TIE10.46312327
121ICK0.44809481
122DYRK20.44658659
123ILK0.43289822
124STK30.41758676
125LRRK20.41235736
126BRD40.40489370
127DAPK20.40468272
128CAMK2G0.39967121
129SIK20.39931056
130MAP3K10.38905698
131ABL20.38573758
132EEF2K0.38426175
133WNK10.38411783
134BCR0.38191727
135RPS6KB10.37659737
136PRKD10.37021279
137CAMK2D0.36064300
138STK110.35319397
139MAPK90.33954713
140MATK0.33394471
141PDK20.32549634
142STK160.32536647
143FGFR30.32411570
144MAPK70.31575623
145IGF1R0.31349424
146SRC0.30906405
147STK390.30665718
148CSNK1E0.30634001

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.49303945
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.69164663
3Focal adhesion_Homo sapiens_hsa045102.10097313
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98168358
5Axon guidance_Homo sapiens_hsa043601.94461279
6Nitrogen metabolism_Homo sapiens_hsa009101.89351258
7Amoebiasis_Homo sapiens_hsa051461.88854787
8Dilated cardiomyopathy_Homo sapiens_hsa054141.87180074
9Basal cell carcinoma_Homo sapiens_hsa052171.87159151
10Hippo signaling pathway_Homo sapiens_hsa043901.85636790
11Bladder cancer_Homo sapiens_hsa052191.82092362
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82033263
13Protein digestion and absorption_Homo sapiens_hsa049741.78855136
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73801179
15Hedgehog signaling pathway_Homo sapiens_hsa043401.73637154
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.70114387
17Phenylalanine metabolism_Homo sapiens_hsa003601.69725570
18Retinol metabolism_Homo sapiens_hsa008301.69428054
19Adherens junction_Homo sapiens_hsa045201.67185369
20beta-Alanine metabolism_Homo sapiens_hsa004101.64724193
21Caffeine metabolism_Homo sapiens_hsa002321.64068653
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.62403330
23Tight junction_Homo sapiens_hsa045301.61533715
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60833282
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51657357
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49611765
27Insulin secretion_Homo sapiens_hsa049111.49440512
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.48955225
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45623647
30Proteoglycans in cancer_Homo sapiens_hsa052051.43643781
31Gastric acid secretion_Homo sapiens_hsa049711.43021983
32Dorso-ventral axis formation_Homo sapiens_hsa043201.38699693
33Cocaine addiction_Homo sapiens_hsa050301.36447210
34Fatty acid degradation_Homo sapiens_hsa000711.34884500
35Melanogenesis_Homo sapiens_hsa049161.34045978
36Small cell lung cancer_Homo sapiens_hsa052221.33956910
37Nicotine addiction_Homo sapiens_hsa050331.31747503
38Wnt signaling pathway_Homo sapiens_hsa043101.26395594
39Estrogen signaling pathway_Homo sapiens_hsa049151.25934009
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20515039
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19001480
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18028227
43TGF-beta signaling pathway_Homo sapiens_hsa043501.17700396
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17232501
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17068860
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15963209
47Renin secretion_Homo sapiens_hsa049241.13837172
48Histidine metabolism_Homo sapiens_hsa003401.13159724
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10461536
50Gap junction_Homo sapiens_hsa045401.09815948
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08954155
52PPAR signaling pathway_Homo sapiens_hsa033201.08758590
53Endometrial cancer_Homo sapiens_hsa052131.03877995
54Ether lipid metabolism_Homo sapiens_hsa005651.02383917
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00563677
56PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00399238
57Amphetamine addiction_Homo sapiens_hsa050310.98883446
58Prion diseases_Homo sapiens_hsa050200.98646804
59MicroRNAs in cancer_Homo sapiens_hsa052060.98237521
60Thyroid cancer_Homo sapiens_hsa052160.96316651
61Thyroid hormone synthesis_Homo sapiens_hsa049180.94982794
62GnRH signaling pathway_Homo sapiens_hsa049120.94450710
63Tyrosine metabolism_Homo sapiens_hsa003500.94092282
64Rap1 signaling pathway_Homo sapiens_hsa040150.94000997
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.91815783
66Mineral absorption_Homo sapiens_hsa049780.90685939
67Fatty acid biosynthesis_Homo sapiens_hsa000610.90070375
68Phototransduction_Homo sapiens_hsa047440.89953944
69Chemical carcinogenesis_Homo sapiens_hsa052040.89266242
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88797452
71Circadian rhythm_Homo sapiens_hsa047100.88550998
72Melanoma_Homo sapiens_hsa052180.87930886
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87827347
74Lysine degradation_Homo sapiens_hsa003100.86975092
75ABC transporters_Homo sapiens_hsa020100.86449985
76Arginine and proline metabolism_Homo sapiens_hsa003300.86218113
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85436074
78Glucagon signaling pathway_Homo sapiens_hsa049220.85409241
79Glycerolipid metabolism_Homo sapiens_hsa005610.83286052
80Glutathione metabolism_Homo sapiens_hsa004800.83103753
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82722914
82Pathways in cancer_Homo sapiens_hsa052000.81086723
83Collecting duct acid secretion_Homo sapiens_hsa049660.80556330
84Choline metabolism in cancer_Homo sapiens_hsa052310.80302009
85Linoleic acid metabolism_Homo sapiens_hsa005910.79816778
86Glioma_Homo sapiens_hsa052140.79710928
87Tryptophan metabolism_Homo sapiens_hsa003800.78771437
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78600916
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.78369781
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78291748
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77897662
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77380755
93Arginine biosynthesis_Homo sapiens_hsa002200.77074321
94Prostate cancer_Homo sapiens_hsa052150.76983732
95Salivary secretion_Homo sapiens_hsa049700.76834919
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73587812
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73346048
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.71855575
99Synaptic vesicle cycle_Homo sapiens_hsa047210.69204974
100Oxytocin signaling pathway_Homo sapiens_hsa049210.67783839
101Serotonergic synapse_Homo sapiens_hsa047260.67510147
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66992540
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66090412
104GABAergic synapse_Homo sapiens_hsa047270.65816758
105Cholinergic synapse_Homo sapiens_hsa047250.63672715
106Sulfur metabolism_Homo sapiens_hsa009200.63444265
107Renal cell carcinoma_Homo sapiens_hsa052110.62843809
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62619283
109Long-term depression_Homo sapiens_hsa047300.62198734
110Starch and sucrose metabolism_Homo sapiens_hsa005000.61433208
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61116444
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60740809
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60592632
114Circadian entrainment_Homo sapiens_hsa047130.60274895
115Morphine addiction_Homo sapiens_hsa050320.59263765
116Glutamatergic synapse_Homo sapiens_hsa047240.58401314
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57894993
118Ras signaling pathway_Homo sapiens_hsa040140.57892631
119Dopaminergic synapse_Homo sapiens_hsa047280.57863092
120Ovarian steroidogenesis_Homo sapiens_hsa049130.57713488
121Vibrio cholerae infection_Homo sapiens_hsa051100.57546929
122Insulin signaling pathway_Homo sapiens_hsa049100.57227777
123Type II diabetes mellitus_Homo sapiens_hsa049300.56028308
124Notch signaling pathway_Homo sapiens_hsa043300.55747689
125Pancreatic secretion_Homo sapiens_hsa049720.55201106
126Inositol phosphate metabolism_Homo sapiens_hsa005620.54187706
127ErbB signaling pathway_Homo sapiens_hsa040120.53918179
128Bile secretion_Homo sapiens_hsa049760.52805283
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52496792
130Sphingolipid metabolism_Homo sapiens_hsa006000.52368376
131Insulin resistance_Homo sapiens_hsa049310.51383984
132AMPK signaling pathway_Homo sapiens_hsa041520.50063339
133Fat digestion and absorption_Homo sapiens_hsa049750.49796561
134Prolactin signaling pathway_Homo sapiens_hsa049170.49325761
135Renin-angiotensin system_Homo sapiens_hsa046140.49193589
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48880397
137Taste transduction_Homo sapiens_hsa047420.44696825
138cAMP signaling pathway_Homo sapiens_hsa040240.44457649
139Calcium signaling pathway_Homo sapiens_hsa040200.44243935
140Arachidonic acid metabolism_Homo sapiens_hsa005900.43807951
141Butanoate metabolism_Homo sapiens_hsa006500.43675994
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43375648
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.42940666
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.41457737
145Olfactory transduction_Homo sapiens_hsa047400.39429049

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