ZBTB8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.22800787
2regulation of nuclear cell cycle DNA replication (GO:0033262)4.34870010
3L-fucose catabolic process (GO:0042355)4.09519885
4fucose catabolic process (GO:0019317)4.09519885
5L-fucose metabolic process (GO:0042354)4.09519885
6protein K6-linked ubiquitination (GO:0085020)4.08834004
7histone H4-K12 acetylation (GO:0043983)3.95223198
8DNA replication initiation (GO:0006270)3.91793700
9tRNA methylation (GO:0030488)3.91544617
10response to pheromone (GO:0019236)3.88056072
11somatic diversification of immune receptors via somatic mutation (GO:0002566)3.77975834
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.77975834
13viral mRNA export from host cell nucleus (GO:0046784)3.73045269
14poly(A)+ mRNA export from nucleus (GO:0016973)3.71683831
15telomere maintenance via semi-conservative replication (GO:0032201)3.69315495
16microtubule depolymerization (GO:0007019)3.58930153
17kidney morphogenesis (GO:0060993)3.58151779
18regulation of helicase activity (GO:0051095)3.53423531
19maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53380509
20termination of RNA polymerase III transcription (GO:0006386)3.45900950
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.45900950
22mismatch repair (GO:0006298)3.43925466
23proteasome assembly (GO:0043248)3.43852521
24DNA deamination (GO:0045006)3.43317223
25transcription elongation from RNA polymerase I promoter (GO:0006362)3.42627593
26mitotic metaphase plate congression (GO:0007080)3.41973186
27ribosome biogenesis (GO:0042254)3.41738514
28kynurenine metabolic process (GO:0070189)3.41701651
29tryptophan catabolic process (GO:0006569)3.32881739
30indole-containing compound catabolic process (GO:0042436)3.32881739
31indolalkylamine catabolic process (GO:0046218)3.32881739
32DNA strand elongation involved in DNA replication (GO:0006271)3.32579432
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31179473
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.29655779
35pseudouridine synthesis (GO:0001522)3.29203954
36somite development (GO:0061053)3.28809418
37maturation of SSU-rRNA (GO:0030490)3.28300292
38termination of RNA polymerase I transcription (GO:0006363)3.26354969
39DNA strand elongation (GO:0022616)3.26312761
40regulation of mesoderm development (GO:2000380)3.26015805
41regulation of timing of cell differentiation (GO:0048505)3.25955576
42regulation of development, heterochronic (GO:0040034)3.25016097
43telomere maintenance via telomere lengthening (GO:0010833)3.24914961
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24768449
45transcription from RNA polymerase I promoter (GO:0006360)3.24708293
46intra-S DNA damage checkpoint (GO:0031573)3.23745103
47DNA methylation involved in gamete generation (GO:0043046)3.22063031
48DNA synthesis involved in DNA repair (GO:0000731)3.21285716
49motile cilium assembly (GO:0044458)3.20096251
50NADH dehydrogenase complex assembly (GO:0010257)3.18412464
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18412464
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.18412464
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18208599
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18208599
55sulfation (GO:0051923)3.15999363
56telomere maintenance via recombination (GO:0000722)3.12325997
57transcription-coupled nucleotide-excision repair (GO:0006283)3.11427780
58meiotic chromosome segregation (GO:0045132)3.10347653
59indolalkylamine metabolic process (GO:0006586)3.09882128
60transcription initiation from RNA polymerase I promoter (GO:0006361)3.06665964
61protein polyglutamylation (GO:0018095)3.06617993
62positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.06509772
63gamma-aminobutyric acid transport (GO:0015812)3.05610284
64negative regulation of telomere maintenance (GO:0032205)3.05162701
65DNA catabolic process, exonucleolytic (GO:0000738)3.05010768
66nonmotile primary cilium assembly (GO:0035058)3.04436270
67spliceosomal complex assembly (GO:0000245)3.04057699
68single strand break repair (GO:0000012)3.02428281
69regulation of gene silencing by RNA (GO:0060966)3.00983256
70regulation of posttranscriptional gene silencing (GO:0060147)3.00983256
71regulation of gene silencing by miRNA (GO:0060964)3.00983256
72replication fork processing (GO:0031297)3.00542177
73neuronal action potential (GO:0019228)3.00446318
74rRNA modification (GO:0000154)2.99757846
75water-soluble vitamin biosynthetic process (GO:0042364)2.98411425
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.98171096
77pyrimidine nucleobase catabolic process (GO:0006208)2.96055285
78cornea development in camera-type eye (GO:0061303)2.95056297
79spliceosomal snRNP assembly (GO:0000387)2.94742345
80purine nucleobase biosynthetic process (GO:0009113)2.94593289
81nephron tubule morphogenesis (GO:0072078)2.93633276
82nephron epithelium morphogenesis (GO:0072088)2.93633276
83regulation of double-strand break repair via homologous recombination (GO:0010569)2.91526253
84regulation of hippo signaling (GO:0035330)2.91055463
85mitotic recombination (GO:0006312)2.90435459
86cellular ketone body metabolic process (GO:0046950)2.89416918
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88942710
88ribonucleoprotein complex biogenesis (GO:0022613)2.88901164
89kinetochore assembly (GO:0051382)2.88885823
90behavioral response to ethanol (GO:0048149)2.88691590
91chromatin remodeling at centromere (GO:0031055)2.88409234
92DNA replication checkpoint (GO:0000076)2.88332222
93epithelial cilium movement (GO:0003351)2.85464221
94tRNA modification (GO:0006400)2.85459059
95reflex (GO:0060004)2.85392026
96nucleobase biosynthetic process (GO:0046112)2.85205081
97histone H4-K5 acetylation (GO:0043981)2.84512731
98histone H4-K8 acetylation (GO:0043982)2.84512731
99spinal cord motor neuron differentiation (GO:0021522)2.84176588
100regulation of action potential (GO:0098900)2.83969530
101metaphase plate congression (GO:0051310)2.83909349
102platelet dense granule organization (GO:0060155)2.83860749
103peristalsis (GO:0030432)2.83652382
104protein complex biogenesis (GO:0070271)2.83416593
105maturation of 5.8S rRNA (GO:0000460)2.81582237
106cell proliferation in forebrain (GO:0021846)2.81050643
107piRNA metabolic process (GO:0034587)2.80299418
108primary amino compound metabolic process (GO:1901160)2.78836017
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78688140
110tryptophan metabolic process (GO:0006568)2.78555254
111DNA ligation (GO:0006266)2.77634041
112CENP-A containing nucleosome assembly (GO:0034080)2.76425845
113detection of light stimulus involved in sensory perception (GO:0050962)2.76196068
114detection of light stimulus involved in visual perception (GO:0050908)2.76196068
115rRNA processing (GO:0006364)2.76024056
116RNA methylation (GO:0001510)2.75576040
117negative regulation of translation, ncRNA-mediated (GO:0040033)2.75221515
118regulation of translation, ncRNA-mediated (GO:0045974)2.75221515
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75221515
120rRNA metabolic process (GO:0016072)2.74631988
121synaptic transmission, cholinergic (GO:0007271)2.72453387
122IMP biosynthetic process (GO:0006188)2.70638403
123indole-containing compound metabolic process (GO:0042430)2.69730073
124regulation of neurotransmitter uptake (GO:0051580)2.69684140
125negative regulation of chromosome segregation (GO:0051985)2.69043086
126tRNA processing (GO:0008033)2.68932714
127head development (GO:0060322)2.67180484
128mitochondrial respiratory chain complex assembly (GO:0033108)2.67155123
129DNA double-strand break processing (GO:0000729)2.66762207
130DNA-templated transcription, termination (GO:0006353)2.66715896
131serotonin metabolic process (GO:0042428)2.66183150
132reciprocal meiotic recombination (GO:0007131)2.65309511
133reciprocal DNA recombination (GO:0035825)2.65309511
134negative regulation of sister chromatid segregation (GO:0033046)2.65275456
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.65275456
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65275456
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65275456
138endoderm formation (GO:0001706)2.65166169
139protein-cofactor linkage (GO:0018065)2.63236324
140neural tube formation (GO:0001841)2.62736313
141cilium morphogenesis (GO:0060271)2.62415175
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61589996
143ncRNA metabolic process (GO:0034660)2.61490573
144negative regulation of mast cell activation (GO:0033004)2.61407850
145telomere organization (GO:0032200)2.60991878
146ketone body metabolic process (GO:1902224)2.60605081
147rRNA methylation (GO:0031167)2.59648207
148preassembly of GPI anchor in ER membrane (GO:0016254)2.59307699
149nucleotide-excision repair (GO:0006289)2.58990859
150telomere maintenance (GO:0000723)2.58436201
151ncRNA processing (GO:0034470)2.57549272
152kinetochore organization (GO:0051383)2.56053877
153DNA strand renaturation (GO:0000733)2.56023885
154telomere maintenance via telomerase (GO:0007004)2.55913738
155nucleobase catabolic process (GO:0046113)2.55892226
156artery development (GO:0060840)2.55520273
157amine catabolic process (GO:0009310)2.55489472
158cellular biogenic amine catabolic process (GO:0042402)2.55489472
159negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55055422
160DNA replication (GO:0006260)2.54939607
161ribosome assembly (GO:0042255)2.53966641
162startle response (GO:0001964)2.53803891
163daunorubicin metabolic process (GO:0044597)2.53360887
164doxorubicin metabolic process (GO:0044598)2.53360887
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50379232
166postsynaptic membrane organization (GO:0001941)2.49760500
167cilium organization (GO:0044782)2.49630985
168hindbrain development (GO:0030902)2.48079904
169transmission of nerve impulse (GO:0019226)2.47794124
170cell differentiation in spinal cord (GO:0021515)2.47705835
171negative regulation of systemic arterial blood pressure (GO:0003085)2.45971453
172positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.45082492
173cellular response to ATP (GO:0071318)2.45068245
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44146048
175axoneme assembly (GO:0035082)2.42490033
176ubiquinone biosynthetic process (GO:0006744)2.40354048
177cilium assembly (GO:0042384)2.40200131
178rhodopsin mediated signaling pathway (GO:0016056)2.38846411
179retinal ganglion cell axon guidance (GO:0031290)2.37876510
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37498328
181regulation of telomere maintenance (GO:0032204)2.37383981
182presynaptic membrane assembly (GO:0097105)2.35528298
183positive regulation of sodium ion transmembrane transport (GO:1902307)2.35142218
184positive regulation of oligodendrocyte differentiation (GO:0048714)2.35014262
185rRNA catabolic process (GO:0016075)2.34855853
186limb bud formation (GO:0060174)2.34735907
187protein localization to cilium (GO:0061512)2.34623540
188photoreceptor cell development (GO:0042461)2.34393618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43457924
2EZH2_22144423_ChIP-Seq_EOC_Human4.01585479
3ZNF274_21170338_ChIP-Seq_K562_Hela3.99773856
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41432129
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.39798826
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.39798826
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.39798826
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22720798
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96429004
10IRF1_19129219_ChIP-ChIP_H3396_Human2.88080428
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80081893
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78123656
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67270375
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63368459
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58271528
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54922670
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.42923760
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39677269
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39617045
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32625477
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.31086616
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28777318
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28537009
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27484521
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26388035
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24364086
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22657692
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.21714640
29FUS_26573619_Chip-Seq_HEK293_Human2.11265384
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.10704664
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10311820
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10306633
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.09531456
34IGF1R_20145208_ChIP-Seq_DFB_Human2.09395026
35SOX2_18555785_ChIP-Seq_MESCs_Mouse2.07659948
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06548242
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.06131554
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04916409
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04894644
40* EWS_26573619_Chip-Seq_HEK293_Human2.02419260
41CBX2_27304074_Chip-Seq_ESCs_Mouse2.02089488
42POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01221931
43GABP_17652178_ChIP-ChIP_JURKAT_Human2.00682876
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96690020
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.94090721
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.91934414
47P300_19829295_ChIP-Seq_ESCs_Human1.91498433
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90287251
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.87974662
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86627021
51VDR_23849224_ChIP-Seq_CD4+_Human1.84977755
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83793122
53NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.82395321
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82269360
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.80130823
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76215821
57ER_23166858_ChIP-Seq_MCF-7_Human1.73901887
58TAF15_26573619_Chip-Seq_HEK293_Human1.72366464
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71396395
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70978833
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70742112
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68525148
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66474452
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66317055
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65545905
66REST_21632747_ChIP-Seq_MESCs_Mouse1.64134358
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63503773
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60800719
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.59092127
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.57923272
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57894891
72FOXP3_21729870_ChIP-Seq_TREG_Human1.56611423
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55728667
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53759402
75TTF2_22483619_ChIP-Seq_HELA_Human1.53621751
76ELK1_19687146_ChIP-ChIP_HELA_Human1.52411427
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52208554
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50894669
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50894669
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50474220
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.50424816
82STAT3_23295773_ChIP-Seq_U87_Human1.50330715
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.49929918
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49908073
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.49723869
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.48725652
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47926110
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47807369
89BCAT_22108803_ChIP-Seq_LS180_Human1.46508139
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46398460
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43640333
92TCF4_23295773_ChIP-Seq_U87_Human1.41990293
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41095452
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.39174594
95AR_25329375_ChIP-Seq_VCAP_Human1.39073812
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38570131
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38023143
98* SMAD4_21799915_ChIP-Seq_A2780_Human1.36700998
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36619498
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36057814
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35159154
102TP53_22573176_ChIP-Seq_HFKS_Human1.33663243
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32276367
104CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30442027
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30246699
106AR_21572438_ChIP-Seq_LNCaP_Human1.29625476
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27683009
108CBP_20019798_ChIP-Seq_JUKART_Human1.27683009
109* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25882607
110XRN2_22483619_ChIP-Seq_HELA_Human1.24864465
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23961097
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.23834372
113DCP1A_22483619_ChIP-Seq_HELA_Human1.23032135
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21608047
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21506606
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20601588
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18765410
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18753244
119RUNX2_22187159_ChIP-Seq_PCA_Human1.18396754
120TCF4_22108803_ChIP-Seq_LS180_Human1.17776620
121* FOXA1_25329375_ChIP-Seq_VCAP_Human1.16557698
122* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16557698
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15683265
124NANOG_19829295_ChIP-Seq_ESCs_Human1.15076456
125SOX2_19829295_ChIP-Seq_ESCs_Human1.15076456
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14297729
127VDR_22108803_ChIP-Seq_LS180_Human1.14060314
128SOX2_16153702_ChIP-ChIP_HESCs_Human1.13427808
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13405073
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13383368
131* GATA3_21878914_ChIP-Seq_MCF-7_Human1.13209331
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13099456
133RNF2_27304074_Chip-Seq_ESCs_Mouse1.13066488
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12824332
135* SMAD4_21741376_ChIP-Seq_EPCs_Human1.12595024
136MYC_18940864_ChIP-ChIP_HL60_Human1.11810689
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.10860983
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09982257
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09072189
140HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09042247
141GBX2_23144817_ChIP-Seq_PC3_Human1.08978348
142NCOR_22424771_ChIP-Seq_293T_Human1.07042263
143REST_18959480_ChIP-ChIP_MESCs_Mouse1.06579158
144SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06484170
145SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05613342
146TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05568252
147ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05410212
148GABP_19822575_ChIP-Seq_HepG2_Human1.04950403
149SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03485405
150NANOG_16153702_ChIP-ChIP_HESCs_Human1.02309047
151RNF2_27304074_Chip-Seq_NSC_Mouse1.02215246
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01966832
153* HOXB7_26014856_ChIP-Seq_BT474_Human1.01601297
154PRDM14_20953172_ChIP-Seq_ESCs_Human1.01083249
155KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00527088
156SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00412843
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.99740932
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99401836
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98409830
160HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98147187
161TP53_16413492_ChIP-PET_HCT116_Human0.98138356
162BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96823508
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96703167
164POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96637808
165POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96537400
166CIITA_25753668_ChIP-Seq_RAJI_Human0.96422014
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.95843975
168* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95304975
169NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94965110
170EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94597402
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93684139
172SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92481081
173ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92408426
174TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91668866
175POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91567065
176RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86378908
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83796535
178NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81899172
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80973821
180NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80465578
181* KAP1_27257070_Chip-Seq_ESCs_Mouse0.79099743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.39862095
2MP0008057_abnormal_DNA_replication3.61713376
3MP0010094_abnormal_chromosome_stability3.55657618
4MP0008058_abnormal_DNA_repair3.44920184
5MP0003693_abnormal_embryo_hatching3.29742005
6MP0003111_abnormal_nucleus_morphology3.21911673
7MP0000566_synostosis2.90983533
8MP0003136_yellow_coat_color2.84807546
9MP0003195_calcinosis2.56739442
10MP0008877_abnormal_DNA_methylation2.45814095
11MP0003077_abnormal_cell_cycle2.44081829
12MP0003646_muscle_fatigue2.38126189
13MP0003786_premature_aging2.29027641
14MP0004957_abnormal_blastocyst_morpholog2.27433659
15MP0003941_abnormal_skin_development2.24308207
16MP0005551_abnormal_eye_electrophysiolog2.22178484
17MP0009046_muscle_twitch2.13864459
18MP0000569_abnormal_digit_pigmentation2.13597747
19MP0005171_absent_coat_pigmentation2.12699292
20MP0001968_abnormal_touch/_nociception2.09747362
21MP0001188_hyperpigmentation2.07178257
22MP0004133_heterotaxia2.06260512
23MP0004885_abnormal_endolymph2.04189504
24MP0002102_abnormal_ear_morphology2.02682203
25MP0008007_abnormal_cellular_replicative2.01864583
26MP0005409_darkened_coat_color2.01777183
27MP0009745_abnormal_behavioral_response1.89168006
28MP0003718_maternal_effect1.86045534
29MP0002837_dystrophic_cardiac_calcinosis1.82638280
30MP0003787_abnormal_imprinting1.78448782
31MP0008872_abnormal_physiological_respon1.75351782
32MP0002736_abnormal_nociception_after1.75350456
33MP0003283_abnormal_digestive_organ1.74989545
34MP0008995_early_reproductive_senescence1.68967593
35MP0002272_abnormal_nervous_system1.68329050
36MP0003890_abnormal_embryonic-extraembry1.65045995
37MP0002277_abnormal_respiratory_mucosa1.63107808
38MP0008932_abnormal_embryonic_tissue1.61052636
39MP0004043_abnormal_pH_regulation1.59321299
40MP0002876_abnormal_thyroid_physiology1.59159934
41MP0000427_abnormal_hair_cycle1.57800972
42MP0003011_delayed_dark_adaptation1.57224665
43MP0002638_abnormal_pupillary_reflex1.56900214
44MP0001986_abnormal_taste_sensitivity1.56049598
45MP0002735_abnormal_chemical_nociception1.54816398
46MP0002132_abnormal_respiratory_system1.52165225
47MP0001486_abnormal_startle_reflex1.51031706
48MP0005645_abnormal_hypothalamus_physiol1.49561708
49MP0004145_abnormal_muscle_electrophysio1.45079525
50MP0003880_abnormal_central_pattern1.44439189
51MP0004147_increased_porphyrin_level1.44032118
52MP0003121_genomic_imprinting1.43967769
53MP0000778_abnormal_nervous_system1.43581372
54MP0006276_abnormal_autonomic_nervous1.42371693
55MP0000049_abnormal_middle_ear1.42367002
56MP0002572_abnormal_emotion/affect_behav1.40339890
57MP0003950_abnormal_plasma_membrane1.33125928
58MP0002557_abnormal_social/conspecific_i1.32993995
59MP0000015_abnormal_ear_pigmentation1.32670949
60MP0008875_abnormal_xenobiotic_pharmacok1.32197366
61MP0000383_abnormal_hair_follicle1.32104232
62MP0002064_seizures1.31662646
63MP0008789_abnormal_olfactory_epithelium1.30321760
64MP0002163_abnormal_gland_morphology1.28462226
65MP0002210_abnormal_sex_determination1.24535340
66MP0002234_abnormal_pharynx_morphology1.23999890
67MP0000613_abnormal_salivary_gland1.21807344
68MP0010030_abnormal_orbit_morphology1.20886289
69MP0001529_abnormal_vocalization1.20592405
70MP0002733_abnormal_thermal_nociception1.20537581
71MP0005367_renal/urinary_system_phenotyp1.20435185
72MP0000516_abnormal_urinary_system1.20435185
73MP0001970_abnormal_pain_threshold1.20331070
74MP0009379_abnormal_foot_pigmentation1.20165048
75MP0005195_abnormal_posterior_eye1.19144293
76MP0002734_abnormal_mechanical_nocicepti1.18993887
77MP0001286_abnormal_eye_development1.18810349
78MP0001293_anophthalmia1.18447176
79MP0002063_abnormal_learning/memory/cond1.18345362
80MP0003635_abnormal_synaptic_transmissio1.17644522
81MP0003123_paternal_imprinting1.17397570
82MP0002067_abnormal_sensory_capabilities1.17006696
83MP0010386_abnormal_urinary_bladder1.16076818
84MP0001501_abnormal_sleep_pattern1.15468686
85MP0005174_abnormal_tail_pigmentation1.12596719
86MP0000490_abnormal_crypts_of1.11153089
87MP0005379_endocrine/exocrine_gland_phen1.11076247
88MP0002184_abnormal_innervation1.10370142
89MP0002249_abnormal_larynx_morphology1.10299594
90MP0005386_behavior/neurological_phenoty1.09491022
91MP0004924_abnormal_behavior1.09491022
92MP0006072_abnormal_retinal_apoptosis1.09078487
93MP0000372_irregular_coat_pigmentation1.05518341
94MP0001145_abnormal_male_reproductive1.04207862
95MP0002752_abnormal_somatic_nervous1.04156355
96MP0005394_taste/olfaction_phenotype1.03969405
97MP0005499_abnormal_olfactory_system1.03969405
98MP0000350_abnormal_cell_proliferation1.03753844
99MP0005423_abnormal_somatic_nervous1.02960669
100MP0001485_abnormal_pinna_reflex1.01944504
101MP0002928_abnormal_bile_duct1.01910706
102MP0000026_abnormal_inner_ear1.00876823
103MP0005084_abnormal_gallbladder_morpholo1.00119018
104MP0005075_abnormal_melanosome_morpholog0.97315881
105MP0003938_abnormal_ear_development0.97184611
106MP0003315_abnormal_perineum_morphology0.97075797
107MP0000678_abnormal_parathyroid_gland0.95590018
108MP0004381_abnormal_hair_follicle0.95233805
109MP0002653_abnormal_ependyma_morphology0.94698296
110MP0002396_abnormal_hematopoietic_system0.94656049
111MP0000955_abnormal_spinal_cord0.94516748
112MP0001186_pigmentation_phenotype0.94149426
113MP0000313_abnormal_cell_death0.93990511
114MP0002075_abnormal_coat/hair_pigmentati0.93756175
115MP0002938_white_spotting0.93552492
116MP0001984_abnormal_olfaction0.93552030
117MP0004742_abnormal_vestibular_system0.93418365
118MP0005646_abnormal_pituitary_gland0.93400992
119MP0009697_abnormal_copulation0.93048378
120MP0001929_abnormal_gametogenesis0.92881767
121MP0002085_abnormal_embryonic_tissue0.92538444
122MP0002160_abnormal_reproductive_system0.91122797
123MP0001905_abnormal_dopamine_level0.90284544
124MP0003137_abnormal_impulse_conducting0.89414713
125MP0000230_abnormal_systemic_arterial0.89303591
126MP0000653_abnormal_sex_gland0.89148763
127MP0000631_abnormal_neuroendocrine_gland0.88887368
128MP0002751_abnormal_autonomic_nervous0.88451478
129MP0003119_abnormal_digestive_system0.87451915
130MP0001502_abnormal_circadian_rhythm0.86079947
131MP0001440_abnormal_grooming_behavior0.84224046
132MP0005389_reproductive_system_phenotype0.83961698
133MP0002111_abnormal_tail_morphology0.83220648
134MP0002882_abnormal_neuron_morphology0.82977788
135MP0001119_abnormal_female_reproductive0.82853456
136MP0005167_abnormal_blood-brain_barrier0.82781014
137MP0001324_abnormal_eye_pigmentation0.82282510
138MP0004130_abnormal_muscle_cell0.82114778
139MP0004142_abnormal_muscle_tone0.81263972
140MP0003937_abnormal_limbs/digits/tail_de0.80848478
141MP0000647_abnormal_sebaceous_gland0.79795744
142MP0001963_abnormal_hearing_physiology0.79217533
143MP0003755_abnormal_palate_morphology0.78216192
144MP0003698_abnormal_male_reproductive0.76803966
145MP0005377_hearing/vestibular/ear_phenot0.76010135
146MP0003878_abnormal_ear_physiology0.76010135
147MP0002116_abnormal_craniofacial_bone0.75383407
148MP0001919_abnormal_reproductive_system0.74772491
149MP0003567_abnormal_fetal_cardiomyocyte0.74205796
150MP0002095_abnormal_skin_pigmentation0.73023292
151MP0003936_abnormal_reproductive_system0.73020585
152MP0002098_abnormal_vibrissa_morphology0.71199318
153MP0000432_abnormal_head_morphology0.70837214
154MP0000762_abnormal_tongue_morphology0.68910042
155MP0005380_embryogenesis_phenotype0.68390324
156MP0001672_abnormal_embryogenesis/_devel0.68390324
157MP0005253_abnormal_eye_physiology0.67776721
158MP0001730_embryonic_growth_arrest0.67494333
159MP0003861_abnormal_nervous_system0.65309516
160MP0005391_vision/eye_phenotype0.64521878
161MP0003186_abnormal_redox_activity0.64323557

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.75400034
2Chromsome breakage (HP:0040012)5.17546948
3Duplicated collecting system (HP:0000081)4.26078537
4Molar tooth sign on MRI (HP:0002419)4.14292325
5Abnormality of midbrain morphology (HP:0002418)4.14292325
6Abnormality of the renal collecting system (HP:0004742)3.80384824
7Congenital stationary night blindness (HP:0007642)3.77503008
8Nephronophthisis (HP:0000090)3.73922008
9Abnormality of the preputium (HP:0100587)3.73333278
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.67745777
11Meckel diverticulum (HP:0002245)3.58354281
12Abnormality of the ileum (HP:0001549)3.50823182
13Type II lissencephaly (HP:0007260)3.32262759
14Pendular nystagmus (HP:0012043)3.28418991
15Birth length less than 3rd percentile (HP:0003561)3.27240663
16Abnormality of chromosome stability (HP:0003220)3.23967775
17Hyperventilation (HP:0002883)3.23065318
18Abnormality of the renal medulla (HP:0100957)3.19489231
19Abnormality of DNA repair (HP:0003254)3.10027865
20Absent radius (HP:0003974)3.08511721
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02998257
22Abnormality of alanine metabolism (HP:0010916)3.02998257
23Hyperalaninemia (HP:0003348)3.02998257
24Breast hypoplasia (HP:0003187)2.95336159
25Supernumerary spleens (HP:0009799)2.94338904
26Absent forearm bone (HP:0003953)2.93148025
27Aplasia involving forearm bones (HP:0009822)2.93148025
28Genetic anticipation (HP:0003743)2.91274250
29Abnormality of the renal cortex (HP:0011035)2.89138852
30Reticulocytopenia (HP:0001896)2.88072900
31Cystic liver disease (HP:0006706)2.87365452
32Tubular atrophy (HP:0000092)2.87133818
33Absent thumb (HP:0009777)2.86832433
34Clubbing of toes (HP:0100760)2.85740142
35Septo-optic dysplasia (HP:0100842)2.71957126
36Intestinal atresia (HP:0011100)2.70249538
37Congenital, generalized hypertrichosis (HP:0004540)2.68916924
38Absent/shortened dynein arms (HP:0200106)2.66052363
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.66052363
40Increased corneal curvature (HP:0100692)2.62463481
41Keratoconus (HP:0000563)2.62463481
42Abolished electroretinogram (ERG) (HP:0000550)2.62374372
43Inability to walk (HP:0002540)2.62103712
44Progressive cerebellar ataxia (HP:0002073)2.59926639
45Abnormality of the carotid arteries (HP:0005344)2.58298963
46Sclerocornea (HP:0000647)2.55065666
47Bone marrow hypocellularity (HP:0005528)2.51815074
48Abnormal respiratory motile cilium morphology (HP:0005938)2.51604734
49Abnormal respiratory epithelium morphology (HP:0012253)2.51604734
50Attenuation of retinal blood vessels (HP:0007843)2.50804440
51Sex reversal (HP:0012245)2.46449789
52Abnormal sex determination (HP:0012244)2.46449789
53Chorioretinal atrophy (HP:0000533)2.44078790
54Gait imbalance (HP:0002141)2.43752724
55Lissencephaly (HP:0001339)2.43674574
56Cerebellar dysplasia (HP:0007033)2.42200215
57Furrowed tongue (HP:0000221)2.41849745
58Duodenal stenosis (HP:0100867)2.41291762
59Small intestinal stenosis (HP:0012848)2.41291762
60Triphalangeal thumb (HP:0001199)2.38403448
61Abnormal drinking behavior (HP:0030082)2.38359563
62Polydipsia (HP:0001959)2.38359563
63Agnosia (HP:0010524)2.38151197
64Chronic hepatic failure (HP:0100626)2.36846534
65Protruding tongue (HP:0010808)2.36770885
66Large for gestational age (HP:0001520)2.36382226
67Anencephaly (HP:0002323)2.34363655
68Congenital primary aphakia (HP:0007707)2.31937669
69Concave nail (HP:0001598)2.31809432
70Optic nerve hypoplasia (HP:0000609)2.29170509
71Upper limb muscle weakness (HP:0003484)2.28619531
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.27774187
73Hypoplasia of the fovea (HP:0007750)2.27774187
74Patellar aplasia (HP:0006443)2.27720942
75Facial cleft (HP:0002006)2.26110955
76Broad-based gait (HP:0002136)2.22521433
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.21524526
78Progressive inability to walk (HP:0002505)2.20276470
79Rectal fistula (HP:0100590)2.19832303
80Rectovaginal fistula (HP:0000143)2.19832303
81Duplication of thumb phalanx (HP:0009942)2.19525902
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19186632
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.18423357
84Myelodysplasia (HP:0002863)2.17910108
85Medulloblastoma (HP:0002885)2.17156668
86Ectopic kidney (HP:0000086)2.17120078
87Short thumb (HP:0009778)2.16540066
88Congenital hepatic fibrosis (HP:0002612)2.15154480
89Nephrogenic diabetes insipidus (HP:0009806)2.14790081
90Aplastic anemia (HP:0001915)2.14664837
91Abnormality of the duodenum (HP:0002246)2.14042139
92Aplasia/Hypoplasia of the patella (HP:0006498)2.13712142
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11077845
94Abnormal rod and cone electroretinograms (HP:0008323)2.10814993
95Gaze-evoked nystagmus (HP:0000640)2.09337175
96Cleft eyelid (HP:0000625)2.06811815
97Asplenia (HP:0001746)2.06631376
98Type I transferrin isoform profile (HP:0003642)2.05628878
99True hermaphroditism (HP:0010459)2.05086416
100Severe muscular hypotonia (HP:0006829)2.04968694
101Tracheoesophageal fistula (HP:0002575)2.04461526
102Premature graying of hair (HP:0002216)2.04276421
103Decreased central vision (HP:0007663)2.04159932
104Sloping forehead (HP:0000340)2.04128301
105Genital tract atresia (HP:0001827)2.03745171
106Vaginal atresia (HP:0000148)2.01717324
107Abnormality of the labia minora (HP:0012880)2.01073534
108Nephroblastoma (Wilms tumor) (HP:0002667)1.97610566
109Tachypnea (HP:0002789)1.97215523
110Osteomalacia (HP:0002749)1.94691180
111Pachygyria (HP:0001302)1.93473076
112Abnormal biliary tract physiology (HP:0012439)1.92609675
113Bile duct proliferation (HP:0001408)1.92609675
114Ependymoma (HP:0002888)1.91818178
115Abnormality of the pons (HP:0007361)1.91791324
116Postaxial foot polydactyly (HP:0001830)1.91552024
117Prostate neoplasm (HP:0100787)1.91337931
118Abnormal ciliary motility (HP:0012262)1.91179756
119Decreased circulating renin level (HP:0003351)1.90368214
120Hypoplasia of the pons (HP:0012110)1.89150175
121Median cleft lip (HP:0000161)1.89064809
122White forelock (HP:0002211)1.88042187
123Horseshoe kidney (HP:0000085)1.87706006
124Clumsiness (HP:0002312)1.87554582
125Rough bone trabeculation (HP:0100670)1.87280617
126Selective tooth agenesis (HP:0001592)1.87242994
127Abnormality of the axillary hair (HP:0100134)1.87122617
128Abnormality of secondary sexual hair (HP:0009888)1.87122617
129Anal stenosis (HP:0002025)1.86805323
130Anophthalmia (HP:0000528)1.86345866
131Polyuria (HP:0000103)1.85793650
132Gastrointestinal atresia (HP:0002589)1.85726403
133Short hallux (HP:0010109)1.85471625
134Male pseudohermaphroditism (HP:0000037)1.85247779
135Aplasia/Hypoplasia of the hallux (HP:0008362)1.84067296
136Pancytopenia (HP:0001876)1.83778303
137Poor coordination (HP:0002370)1.83627399
138Bilateral microphthalmos (HP:0007633)1.83618232
139Acute lymphatic leukemia (HP:0006721)1.82742370
140Esophageal atresia (HP:0002032)1.82180256
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.81241682
142Intestinal fistula (HP:0100819)1.80358030
143Partial agenesis of the corpus callosum (HP:0001338)1.80038791
144Embryonal renal neoplasm (HP:0011794)1.79792434
145Hypergonadotropic hypogonadism (HP:0000815)1.79685850
146Renal cortical cysts (HP:0000803)1.79531856
147Dandy-Walker malformation (HP:0001305)1.78559242
148Small hand (HP:0200055)1.77607125
149Stomach cancer (HP:0012126)1.77316843
150Pancreatic cysts (HP:0001737)1.77146533
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76800206
152Microvesicular hepatic steatosis (HP:0001414)1.76132127
153Hemiparesis (HP:0001269)1.74586925
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74492951
155Preaxial hand polydactyly (HP:0001177)1.72711632
156Impulsivity (HP:0100710)1.72376449
157Abnormal respiratory motile cilium physiology (HP:0012261)1.70438718
158Hypoplasia of the radius (HP:0002984)1.68658237
159Acute necrotizing encephalopathy (HP:0006965)1.68403465
160Aganglionic megacolon (HP:0002251)1.67927216
161Abnormal number of incisors (HP:0011064)1.67879084
162Medial flaring of the eyebrow (HP:0010747)1.66898437
163Patchy hypopigmentation of hair (HP:0011365)1.66359076
164Postaxial hand polydactyly (HP:0001162)1.63949516
165Gastroesophageal reflux (HP:0002020)1.63558156
166Aplasia/hypoplasia of the uterus (HP:0008684)1.63536190
167Astigmatism (HP:0000483)1.63404632
168Pancreatic fibrosis (HP:0100732)1.63274509
169Absent septum pellucidum (HP:0001331)1.62878270
170Oligodactyly (hands) (HP:0001180)1.62797685
171Rib fusion (HP:0000902)1.61209173
172Optic disc pallor (HP:0000543)1.61195780
173Carpal bone hypoplasia (HP:0001498)1.61065955
174Overfolded helix (HP:0000396)1.60613209
175Shawl scrotum (HP:0000049)1.60258261
176Morphological abnormality of the inner ear (HP:0011390)1.59646694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.97581987
2STK164.17845291
3CASK4.14272672
4AKT33.07757936
5ZAK2.89631218
6IRAK42.51413634
7MKNK22.51033002
8SRPK12.50260802
9YES12.45919619
10WNK42.45410041
11BUB12.43367177
12IRAK32.35898287
13EPHA22.18608006
14GRK12.17577690
15TLK12.09304717
16MKNK12.07166572
17INSRR2.04449989
18MAP4K22.00630937
19WEE11.92393633
20TSSK61.88146800
21PLK41.88106293
22TAOK31.85528114
23CDC71.85372778
24NEK61.84684043
25TTK1.83276717
26PNCK1.81433457
27TGFBR11.80807080
28CDK71.79150017
29MAP3K41.75901755
30MAPK131.72458599
31MARK11.61570596
32EIF2AK21.61520912
33VRK11.60724694
34DAPK21.60700404
35NTRK31.58051234
36PLK11.46783201
37ATR1.43245955
38EIF2AK31.42072516
39TNIK1.42004292
40BRD41.40365900
41MAP3K61.39893412
42BLK1.39417827
43OXSR11.38560693
44PRPF4B1.38264606
45CHEK21.33610673
46STK391.33322079
47ADRBK11.32927926
48CDK121.32801282
49STK38L1.32233740
50PLK31.24319081
51MAP3K121.21713148
52ADRBK21.16379501
53DYRK21.13357242
54MAP2K71.08205841
55PRKCG1.04349523
56TXK0.96931161
57PAK30.96095138
58PASK0.95059454
59NTRK20.92130272
60AURKB0.91494133
61BRSK20.90001378
62RPS6KB20.88197774
63MAPK150.86934523
64PRKCI0.85633027
65PIK3CA0.85439647
66CDK30.84023123
67BMPR20.82449664
68DYRK30.79715392
69CHEK10.78819777
70BRAF0.78705729
71PRKCE0.77820729
72CAMKK20.76116953
73PBK0.75567738
74CSNK1G20.75412172
75ATM0.73701268
76ERBB30.73217812
77PIM10.72558362
78MAP2K60.70997981
79PHKG10.69879692
80PHKG20.69879692
81SIK20.69459594
82PTK2B0.68765643
83RPS6KA50.67530285
84AURKA0.66171440
85IRAK20.65758462
86IRAK10.64500828
87TAOK20.63765350
88MAP3K140.63390524
89EPHB20.63297591
90FGFR20.62976687
91GRK70.62117624
92BCR0.61865607
93MAP3K110.61087655
94EPHA40.60422096
95CAMK2A0.59210857
96PINK10.59133602
97MAPKAPK30.58463148
98WNK30.57968634
99CSNK2A10.56465402
100CDK20.56374049
101CSNK1G10.55655494
102STK110.55342184
103BCKDK0.55228614
104ACVR1B0.55015662
105PDK20.54890322
106FLT30.54063515
107CDK10.53987608
108MST40.53361570
109MUSK0.53153305
110PIM20.52215901
111CSNK1G30.51930033
112MAP2K10.50475585
113EPHA30.49891318
114CSNK1A1L0.49526752
115TIE10.49257367
116CSNK2A20.48896634
117RPS6KA60.48579413
118CAMK10.48316683
119BMPR1B0.48109034
120TRIM280.46696912
121MAP2K40.46679966
122WNK10.46648633
123SIK30.46029763
124PKN10.46022504
125MAP2K30.45776983
126OBSCN0.45543233
127CSNK1A10.43680078
128PRKACA0.43039407
129NEK20.42560832
130IKBKB0.41255083
131NME10.40134275
132PRKAA10.39791481
133TYK20.39729290
134STK30.38146162
135MAPKAPK50.38105138
136PRKCQ0.38000377
137CCNB10.37442073
138CDK190.35892327
139AKT10.35605693
140CSNK1D0.35291528
141MAP3K30.34772928
142KIT0.34379901
143TYRO30.34132924
144TAF10.33854843
145DYRK1A0.33592175
146TEC0.32903150
147CDK90.32743525
148MATK0.31994487
149PRKCZ0.31901148
150CHUK0.31160347
151ERBB20.30992460
152MAPK140.30839008
153NUAK10.29808212
154MAP3K50.28919079
155RPS6KA40.28739066
156CAMKK10.28663079
157CSNK1E0.28526431
158GSK3B0.27764160
159SGK20.27278321
160PLK20.27110855
161EIF2AK10.26613329
162RPS6KL10.25790007
163RPS6KC10.25790007

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.05127639
2DNA replication_Homo sapiens_hsa030304.01689427
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51953657
4Homologous recombination_Homo sapiens_hsa034403.48088268
5RNA polymerase_Homo sapiens_hsa030203.41675244
6Fanconi anemia pathway_Homo sapiens_hsa034603.36355334
7Selenocompound metabolism_Homo sapiens_hsa004502.85877379
8Base excision repair_Homo sapiens_hsa034102.84723325
9Nucleotide excision repair_Homo sapiens_hsa034202.75790816
10Spliceosome_Homo sapiens_hsa030402.75302733
11Nitrogen metabolism_Homo sapiens_hsa009102.51408315
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45071778
13Basal transcription factors_Homo sapiens_hsa030222.36681112
14Ribosome_Homo sapiens_hsa030102.36316814
15Pyrimidine metabolism_Homo sapiens_hsa002402.28056255
16RNA transport_Homo sapiens_hsa030132.24184027
17One carbon pool by folate_Homo sapiens_hsa006702.15258211
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03710350
19Butanoate metabolism_Homo sapiens_hsa006501.99877842
20Oxidative phosphorylation_Homo sapiens_hsa001901.99513476
21Cell cycle_Homo sapiens_hsa041101.85660552
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84753358
23Proteasome_Homo sapiens_hsa030501.84295215
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79464425
25RNA degradation_Homo sapiens_hsa030181.67982594
26Purine metabolism_Homo sapiens_hsa002301.65886289
27mRNA surveillance pathway_Homo sapiens_hsa030151.61851464
28Non-homologous end-joining_Homo sapiens_hsa034501.60047352
29Morphine addiction_Homo sapiens_hsa050321.58517052
30Tryptophan metabolism_Homo sapiens_hsa003801.55885264
31Parkinsons disease_Homo sapiens_hsa050121.52595346
32p53 signaling pathway_Homo sapiens_hsa041151.50684364
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50435980
34Caffeine metabolism_Homo sapiens_hsa002321.40825984
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36933132
36Cardiac muscle contraction_Homo sapiens_hsa042601.31558934
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25292471
38Olfactory transduction_Homo sapiens_hsa047401.22366097
39Circadian entrainment_Homo sapiens_hsa047131.21670621
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20095258
41GABAergic synapse_Homo sapiens_hsa047271.18704650
42Glutamatergic synapse_Homo sapiens_hsa047241.18036350
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17289047
44Insulin secretion_Homo sapiens_hsa049111.13919958
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09728858
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.06014517
47Alzheimers disease_Homo sapiens_hsa050101.05482513
48Protein export_Homo sapiens_hsa030601.05329389
49Sulfur metabolism_Homo sapiens_hsa009201.04892464
50Chemical carcinogenesis_Homo sapiens_hsa052041.00868559
51Peroxisome_Homo sapiens_hsa041460.98892572
52Propanoate metabolism_Homo sapiens_hsa006400.97951209
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97471242
54Sulfur relay system_Homo sapiens_hsa041220.97043230
55Autoimmune thyroid disease_Homo sapiens_hsa053200.96918353
56Vitamin B6 metabolism_Homo sapiens_hsa007500.95524172
57ABC transporters_Homo sapiens_hsa020100.95432382
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95427537
59Herpes simplex infection_Homo sapiens_hsa051680.93437475
60Glycerolipid metabolism_Homo sapiens_hsa005610.92871145
61Arachidonic acid metabolism_Homo sapiens_hsa005900.91550307
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90955891
63Ovarian steroidogenesis_Homo sapiens_hsa049130.90283844
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90190813
65Allograft rejection_Homo sapiens_hsa053300.89311845
66Sphingolipid metabolism_Homo sapiens_hsa006000.89188553
67Phototransduction_Homo sapiens_hsa047440.88353942
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86534623
69Retinol metabolism_Homo sapiens_hsa008300.84842218
70Fat digestion and absorption_Homo sapiens_hsa049750.82978160
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82408205
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.81822879
73Epstein-Barr virus infection_Homo sapiens_hsa051690.80609407
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79395614
75Systemic lupus erythematosus_Homo sapiens_hsa053220.78641585
76Calcium signaling pathway_Homo sapiens_hsa040200.77038734
77Dopaminergic synapse_Homo sapiens_hsa047280.76502906
78Cocaine addiction_Homo sapiens_hsa050300.74478344
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.74297569
80Notch signaling pathway_Homo sapiens_hsa043300.72959809
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71953662
82Histidine metabolism_Homo sapiens_hsa003400.71208523
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69753876
84Primary immunodeficiency_Homo sapiens_hsa053400.69014939
85Salivary secretion_Homo sapiens_hsa049700.67776683
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66804420
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66691194
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65504624
89Linoleic acid metabolism_Homo sapiens_hsa005910.64532977
90Long-term depression_Homo sapiens_hsa047300.64181915
91Ether lipid metabolism_Homo sapiens_hsa005650.63811614
92beta-Alanine metabolism_Homo sapiens_hsa004100.63378548
93Measles_Homo sapiens_hsa051620.61701932
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61294822
95Hematopoietic cell lineage_Homo sapiens_hsa046400.60531205
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60406927
97Dorso-ventral axis formation_Homo sapiens_hsa043200.60171387
98Cholinergic synapse_Homo sapiens_hsa047250.60101450
99Axon guidance_Homo sapiens_hsa043600.57313862
100Arginine and proline metabolism_Homo sapiens_hsa003300.56360697
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.56360239
102Regulation of autophagy_Homo sapiens_hsa041400.55265519
103Folate biosynthesis_Homo sapiens_hsa007900.54968462
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54455246
105Basal cell carcinoma_Homo sapiens_hsa052170.53947173
106Steroid biosynthesis_Homo sapiens_hsa001000.53282111
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53198660
108Viral carcinogenesis_Homo sapiens_hsa052030.52442881
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.51417317
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50120191
111Circadian rhythm_Homo sapiens_hsa047100.49953416
112Mineral absorption_Homo sapiens_hsa049780.49877529
113Asthma_Homo sapiens_hsa053100.49719852
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.49100675
115Graft-versus-host disease_Homo sapiens_hsa053320.48349859
116Nicotine addiction_Homo sapiens_hsa050330.48276772
117Other glycan degradation_Homo sapiens_hsa005110.48174598
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47077191
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46308429
120cAMP signaling pathway_Homo sapiens_hsa040240.45704553
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45389098
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45071278
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42749337
124HTLV-I infection_Homo sapiens_hsa051660.42066238
125Huntingtons disease_Homo sapiens_hsa050160.41335244
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40782262
127Gastric acid secretion_Homo sapiens_hsa049710.40296106
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39485737
129Oxytocin signaling pathway_Homo sapiens_hsa049210.39402964
130Alcoholism_Homo sapiens_hsa050340.39289797
131Amphetamine addiction_Homo sapiens_hsa050310.38489192
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37733567
133Taste transduction_Homo sapiens_hsa047420.37646231
134Influenza A_Homo sapiens_hsa051640.35695725
135Legionellosis_Homo sapiens_hsa051340.34261700
136Oocyte meiosis_Homo sapiens_hsa041140.33596086
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33270216
138Wnt signaling pathway_Homo sapiens_hsa043100.32377473
139Vitamin digestion and absorption_Homo sapiens_hsa049770.31554644
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.31380747
141Metabolic pathways_Homo sapiens_hsa011000.30143759
142Collecting duct acid secretion_Homo sapiens_hsa049660.29740694
143MicroRNAs in cancer_Homo sapiens_hsa052060.29722450
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28692390
145Inositol phosphate metabolism_Homo sapiens_hsa005620.27475273
146Melanoma_Homo sapiens_hsa052180.26367712
147Hedgehog signaling pathway_Homo sapiens_hsa043400.26321108
148Apoptosis_Homo sapiens_hsa042100.23772046
149Glutathione metabolism_Homo sapiens_hsa004800.23318759
150Pathways in cancer_Homo sapiens_hsa052000.23039857
151Hippo signaling pathway_Homo sapiens_hsa043900.22940412
152Type I diabetes mellitus_Homo sapiens_hsa049400.21729154
153Rheumatoid arthritis_Homo sapiens_hsa053230.21070795
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20974519
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.18794477
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17953540
157Antigen processing and presentation_Homo sapiens_hsa046120.17925646
158TGF-beta signaling pathway_Homo sapiens_hsa043500.17501821
159Serotonergic synapse_Homo sapiens_hsa047260.15632857

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