ZBTB8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.99287252
2L-fucose catabolic process (GO:0042355)4.43573438
3fucose catabolic process (GO:0019317)4.43573438
4L-fucose metabolic process (GO:0042354)4.43573438
5mitotic metaphase plate congression (GO:0007080)4.17328867
6piRNA metabolic process (GO:0034587)4.12011237
7kynurenine metabolic process (GO:0070189)4.01622366
8tryptophan catabolic process (GO:0006569)4.00460200
9indole-containing compound catabolic process (GO:0042436)4.00460200
10indolalkylamine catabolic process (GO:0046218)4.00460200
11kinetochore assembly (GO:0051382)3.94037565
12response to pheromone (GO:0019236)3.88784731
13kinetochore organization (GO:0051383)3.81496469
14indolalkylamine metabolic process (GO:0006586)3.81287597
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71175260
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69545134
17DNA deamination (GO:0045006)3.67634822
18gamma-aminobutyric acid transport (GO:0015812)3.64311427
19base-excision repair, AP site formation (GO:0006285)3.59382063
20meiotic chromosome segregation (GO:0045132)3.59201823
21protein K6-linked ubiquitination (GO:0085020)3.57346078
22superoxide anion generation (GO:0042554)3.52189116
23regulation of double-strand break repair via homologous recombination (GO:0010569)3.48703195
24microtubule depolymerization (GO:0007019)3.48615725
25tryptophan metabolic process (GO:0006568)3.45711586
26establishment of chromosome localization (GO:0051303)3.42128345
27metaphase plate congression (GO:0051310)3.41410408
28cellular ketone body metabolic process (GO:0046950)3.39401221
29regulation of female gonad development (GO:2000194)3.38253977
30detection of light stimulus involved in visual perception (GO:0050908)3.38039434
31detection of light stimulus involved in sensory perception (GO:0050962)3.38039434
32sulfation (GO:0051923)3.36951111
33replication fork processing (GO:0031297)3.28079675
34pyrimidine nucleobase catabolic process (GO:0006208)3.27730459
35negative regulation of meiosis (GO:0045835)3.25225504
36regulation of mitotic spindle checkpoint (GO:1903504)3.23776021
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23776021
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13930029
39neuronal action potential (GO:0019228)3.13347052
40DNA synthesis involved in DNA repair (GO:0000731)3.11529869
41kidney morphogenesis (GO:0060993)3.10475312
42protein polyglutamylation (GO:0018095)3.10042978
43epithelial cilium movement (GO:0003351)3.08443124
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07587138
45DNA methylation involved in gamete generation (GO:0043046)3.06356488
46indole-containing compound metabolic process (GO:0042430)3.06138396
47ketone body metabolic process (GO:1902224)3.05569110
48histone H2A acetylation (GO:0043968)3.03696423
49spindle checkpoint (GO:0031577)3.03009707
50behavioral response to ethanol (GO:0048149)3.02416052
51neural tube formation (GO:0001841)3.02385074
52CENP-A containing nucleosome assembly (GO:0034080)3.01854177
53RNA capping (GO:0036260)3.01755365
547-methylguanosine RNA capping (GO:0009452)3.01755365
55positive regulation of DNA-dependent DNA replication (GO:2000105)2.98830629
567-methylguanosine mRNA capping (GO:0006370)2.98442955
57regulation of gene silencing by RNA (GO:0060966)2.96620198
58regulation of posttranscriptional gene silencing (GO:0060147)2.96620198
59regulation of gene silencing by miRNA (GO:0060964)2.96620198
60reflex (GO:0060004)2.95267231
61purine nucleobase biosynthetic process (GO:0009113)2.94875358
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93639106
63negative regulation of mast cell activation (GO:0033004)2.91253029
64water-soluble vitamin biosynthetic process (GO:0042364)2.89982350
65replicative senescence (GO:0090399)2.89408700
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.88582883
67reciprocal meiotic recombination (GO:0007131)2.88101387
68reciprocal DNA recombination (GO:0035825)2.88101387
69regulation of action potential (GO:0098900)2.86914734
70nonmotile primary cilium assembly (GO:0035058)2.86805654
71chromatin remodeling at centromere (GO:0031055)2.86594480
72platelet dense granule organization (GO:0060155)2.84516710
73primary amino compound metabolic process (GO:1901160)2.84417900
74proteasome assembly (GO:0043248)2.82104751
75negative regulation of mitotic sister chromatid separation (GO:2000816)2.81096388
76negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81096388
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81096388
78negative regulation of sister chromatid segregation (GO:0033046)2.81096388
79positive regulation of mitochondrial fission (GO:0090141)2.80628857
80nucleobase catabolic process (GO:0046113)2.80309503
81synaptic transmission, cholinergic (GO:0007271)2.80145533
82negative regulation of translation, ncRNA-mediated (GO:0040033)2.80010973
83regulation of translation, ncRNA-mediated (GO:0045974)2.80010973
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80010973
85regulation of hippo signaling (GO:0035330)2.79944506
86DNA replication initiation (GO:0006270)2.79339101
87female gonad development (GO:0008585)2.79146198
88mitotic spindle checkpoint (GO:0071174)2.78016900
89nucleobase biosynthetic process (GO:0046112)2.77471786
90transmission of nerve impulse (GO:0019226)2.77310243
91DNA replication checkpoint (GO:0000076)2.77075893
92spindle assembly checkpoint (GO:0071173)2.76652721
93axoneme assembly (GO:0035082)2.76489239
94negative regulation of chromosome segregation (GO:0051985)2.76409936
95mitotic spindle assembly checkpoint (GO:0007094)2.75266070
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74554506
97serotonin metabolic process (GO:0042428)2.73812117
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.73749781
99attachment of spindle microtubules to kinetochore (GO:0008608)2.73036881
100rRNA catabolic process (GO:0016075)2.72213328
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71908987
102centriole assembly (GO:0098534)2.71781976
103nuclear pore complex assembly (GO:0051292)2.71736858
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.70567694
105DNA double-strand break processing (GO:0000729)2.69919733
106presynaptic membrane assembly (GO:0097105)2.69337723
107cellular biogenic amine catabolic process (GO:0042402)2.68710079
108amine catabolic process (GO:0009310)2.68710079
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68459908
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68333739
111mismatch repair (GO:0006298)2.68182465
112protein localization to kinetochore (GO:0034501)2.68018541
113postsynaptic membrane organization (GO:0001941)2.67755243
114regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67358462
115regulation of mesoderm development (GO:2000380)2.67316060
116photoreceptor cell maintenance (GO:0045494)2.67289553
117chromosome segregation (GO:0007059)2.66548130
118lens development in camera-type eye (GO:0002088)2.66490921
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65995586
120cilium movement (GO:0003341)2.65587377
121centriole replication (GO:0007099)2.65558002
122DNA replication-independent nucleosome assembly (GO:0006336)2.64698727
123DNA replication-independent nucleosome organization (GO:0034724)2.64698727
124DNA damage response, detection of DNA damage (GO:0042769)2.64011400
125negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63856737
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62871996
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.62871996
128NADH dehydrogenase complex assembly (GO:0010257)2.62871996
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62132978
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61777829
131rhodopsin mediated signaling pathway (GO:0016056)2.61434462
132G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60835573
133cilium morphogenesis (GO:0060271)2.60756793
134spinal cord motor neuron differentiation (GO:0021522)2.60487964
135startle response (GO:0001964)2.60007251
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.59952349
137DNA catabolic process, exonucleolytic (GO:0000738)2.59928850
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59728970
139somite development (GO:0061053)2.59027715
140cellular response to ATP (GO:0071318)2.58665119
141negative regulation of nuclear division (GO:0051784)2.57811463
142cornea development in camera-type eye (GO:0061303)2.57690829
143mitotic sister chromatid segregation (GO:0000070)2.56362029
144regulation of mitotic sister chromatid separation (GO:0010965)2.56304260
145regulation of mitotic sister chromatid segregation (GO:0033047)2.56304260
146regulation of sister chromatid segregation (GO:0033045)2.56304260
147cilium organization (GO:0044782)2.55808703
148nephron tubule morphogenesis (GO:0072078)2.55116009
149nephron epithelium morphogenesis (GO:0072088)2.55116009
150cilium or flagellum-dependent cell motility (GO:0001539)2.54484542
151protein localization to cilium (GO:0061512)2.54473129
152protein complex biogenesis (GO:0070271)2.54448965
153detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53874422
154retinal cone cell development (GO:0046549)2.52992612
155RNA-dependent DNA replication (GO:0006278)2.52850320
156cAMP catabolic process (GO:0006198)2.52431064
157transcription-coupled nucleotide-excision repair (GO:0006283)2.52108896
158telomere maintenance via recombination (GO:0000722)2.51925854
159regulation of cilium movement (GO:0003352)2.51505348
160oxidative demethylation (GO:0070989)2.51449501
161membrane depolarization during action potential (GO:0086010)2.51104988
162protein K11-linked deubiquitination (GO:0035871)2.49092842
163nuclear pore organization (GO:0006999)2.48733311
164termination of RNA polymerase III transcription (GO:0006386)2.48705295
165transcription elongation from RNA polymerase III promoter (GO:0006385)2.48705295
166negative regulation of mitosis (GO:0045839)2.48480973
167DNA-dependent DNA replication (GO:0006261)2.48022485
168preassembly of GPI anchor in ER membrane (GO:0016254)2.47926401
169cilium assembly (GO:0042384)2.47732151
170female gamete generation (GO:0007292)2.46457033
171regulation of helicase activity (GO:0051095)2.46233087
172regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45283325
173photoreceptor cell development (GO:0042461)2.45203281
174paraxial mesoderm development (GO:0048339)2.44919840
175negative regulation of cell division (GO:0051782)2.43927898
176male meiosis (GO:0007140)2.43626654
177respiratory chain complex IV assembly (GO:0008535)2.43438575
178positive regulation of fatty acid transport (GO:2000193)2.43403353
179protein K11-linked ubiquitination (GO:0070979)2.42902371
180mitotic recombination (GO:0006312)2.42504476
181ganglion development (GO:0061548)2.42230464
182regulation of telomere maintenance (GO:0032204)2.41626824
183histone exchange (GO:0043486)2.41386825
184proline transport (GO:0015824)2.41064366
185regulation of transcription from RNA polymerase I promoter (GO:0006356)2.39386444
186anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.38966396
187telomere maintenance via telomerase (GO:0007004)2.37958194
188transcription elongation from RNA polymerase II promoter (GO:0006368)2.37410483
189negative regulation of telomere maintenance (GO:0032205)2.36690979
190telomere maintenance via telomere lengthening (GO:0010833)2.36571675
191intra-S DNA damage checkpoint (GO:0031573)2.36381155
192regulation of chromosome segregation (GO:0051983)2.36326210
193oocyte maturation (GO:0001556)2.35177584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.07294224
2ZNF274_21170338_ChIP-Seq_K562_Hela3.86526440
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.83419290
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.73700015
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60608868
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57819569
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53961032
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48375105
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.42231400
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34938427
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.20284218
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16423120
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15870603
14TAF15_26573619_Chip-Seq_HEK293_Human2.14934639
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11596025
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.10221761
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09381843
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.08658344
19GBX2_23144817_ChIP-Seq_PC3_Human1.99521646
20IGF1R_20145208_ChIP-Seq_DFB_Human1.95992283
21EZH2_22144423_ChIP-Seq_EOC_Human1.88574710
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85728122
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83861328
24ER_23166858_ChIP-Seq_MCF-7_Human1.83305128
25FUS_26573619_Chip-Seq_HEK293_Human1.81840796
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79992698
27* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79475864
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76373849
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.76028067
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74507478
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74429313
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68718511
33RNF2_27304074_Chip-Seq_NSC_Mouse1.67714317
34REST_21632747_ChIP-Seq_MESCs_Mouse1.67571668
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67150050
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66516396
37EWS_26573619_Chip-Seq_HEK293_Human1.65738501
38VDR_22108803_ChIP-Seq_LS180_Human1.64155001
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63445045
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.63098727
41STAT3_23295773_ChIP-Seq_U87_Human1.58749178
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58700280
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58529577
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57297391
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57232092
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.56487838
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55897010
48BCAT_22108803_ChIP-Seq_LS180_Human1.54800131
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54370523
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53309375
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52598979
52AR_25329375_ChIP-Seq_VCAP_Human1.48640939
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48273484
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.47842720
55TP53_22573176_ChIP-Seq_HFKS_Human1.46701361
56* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46337929
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.46126698
58CBP_20019798_ChIP-Seq_JUKART_Human1.45142946
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45142946
60* TCF4_23295773_ChIP-Seq_U87_Human1.45023833
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44570768
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.44442251
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44181865
64* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44108065
65* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44108065
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43857337
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43822924
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42800054
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41713318
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.41677635
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.41178056
72P53_22387025_ChIP-Seq_ESCs_Mouse1.40506572
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.40151651
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39257339
75AR_21572438_ChIP-Seq_LNCaP_Human1.39159529
76ELK1_19687146_ChIP-ChIP_HELA_Human1.38358007
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.38087589
78IRF1_19129219_ChIP-ChIP_H3396_Human1.37898422
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37030499
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.36242115
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36107003
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36015379
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.35799042
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33405887
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32987618
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32534506
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31184570
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30638177
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29412583
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29011596
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.28347651
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27948068
93NANOG_19829295_ChIP-Seq_ESCs_Human1.27314907
94SOX2_19829295_ChIP-Seq_ESCs_Human1.27314907
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.25270816
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.24884855
97P300_18555785_Chip-Seq_ESCs_Mouse1.24701728
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.24473847
99RUNX2_22187159_ChIP-Seq_PCA_Human1.23949523
100TCF4_22108803_ChIP-Seq_LS180_Human1.23859026
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.22878771
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22273546
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22219888
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.22219888
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22108101
106MYC_18940864_ChIP-ChIP_HL60_Human1.21884817
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.21605445
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21332021
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20764197
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19443170
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19223859
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.18562584
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.18235662
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.18022143
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17902531
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16500615
117P300_19829295_ChIP-Seq_ESCs_Human1.15965247
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.15518769
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15513759
120VDR_23849224_ChIP-Seq_CD4+_Human1.14798514
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14702569
122PU1_27457419_Chip-Seq_LIVER_Mouse1.14373805
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.12881704
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11796898
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11752165
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11338859
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11296743
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.10704604
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.09751449
130YY1_21170310_ChIP-Seq_MESCs_Mouse1.09656739
131NCOR_22424771_ChIP-Seq_293T_Human1.09323293
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.09044593
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07931452
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07622096
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.07460367
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05807828
137REST_18959480_ChIP-ChIP_MESCs_Mouse1.04913939
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04647682
139SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04620812
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03924191
141DROSHA_22980978_ChIP-Seq_HELA_Human1.03594798
142NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02744619
143ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02590585
144EZH2_27294783_Chip-Seq_ESCs_Mouse1.02060700
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01469939
146AR_20517297_ChIP-Seq_VCAP_Human1.00317204
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00108210
148HOXB7_26014856_ChIP-Seq_BT474_Human0.99886785
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99102507
150* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98845799
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98223278
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.97654657
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97050568
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95037850
155SMAD4_21799915_ChIP-Seq_A2780_Human0.94272642
156MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92598365
157MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91073829
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.90776542
159E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89926689
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89348829
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86286541
162CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85939845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.05773402
2MP0006292_abnormal_olfactory_placode4.00141987
3MP0003787_abnormal_imprinting3.90700327
4MP0003693_abnormal_embryo_hatching3.00394279
5MP0008058_abnormal_DNA_repair2.95215765
6MP0010094_abnormal_chromosome_stability2.94560403
7MP0008877_abnormal_DNA_methylation2.83053028
8MP0003195_calcinosis2.63585474
9MP0001968_abnormal_touch/_nociception2.61041214
10MP0003111_abnormal_nucleus_morphology2.59385371
11MP0008057_abnormal_DNA_replication2.54099246
12MP0003718_maternal_effect2.51030993
13MP0002102_abnormal_ear_morphology2.41092400
14MP0005551_abnormal_eye_electrophysiolog2.35512565
15MP0000566_synostosis2.32946592
16MP0005646_abnormal_pituitary_gland2.21916318
17MP0009046_muscle_twitch2.19336897
18MP0003077_abnormal_cell_cycle2.15617095
19MP0009745_abnormal_behavioral_response2.15556903
20MP0001188_hyperpigmentation2.14673895
21MP0003121_genomic_imprinting2.08737947
22MP0008789_abnormal_olfactory_epithelium2.08536141
23MP0002638_abnormal_pupillary_reflex2.06926855
24MP0001986_abnormal_taste_sensitivity2.04148889
25MP0003123_paternal_imprinting2.04075885
26MP0008007_abnormal_cellular_replicative1.96970392
27MP0001346_abnormal_lacrimal_gland1.92251912
28MP0004142_abnormal_muscle_tone1.91746423
29MP0004885_abnormal_endolymph1.87605880
30MP0008872_abnormal_physiological_respon1.86971581
31MP0002735_abnormal_chemical_nociception1.82413254
32MP0004043_abnormal_pH_regulation1.82030288
33MP0002272_abnormal_nervous_system1.81644074
34MP0006072_abnormal_retinal_apoptosis1.77539686
35MP0002837_dystrophic_cardiac_calcinosis1.76603952
36MP0001119_abnormal_female_reproductive1.74079747
37MP0009697_abnormal_copulation1.73578610
38MP0003941_abnormal_skin_development1.68306537
39MP0005394_taste/olfaction_phenotype1.64968326
40MP0005499_abnormal_olfactory_system1.64968326
41MP0001486_abnormal_startle_reflex1.62104637
42MP0004782_abnormal_surfactant_physiolog1.61923703
43MP0001501_abnormal_sleep_pattern1.61747550
44MP0004147_increased_porphyrin_level1.58733579
45MP0004133_heterotaxia1.55247106
46MP0004742_abnormal_vestibular_system1.54715876
47MP0002064_seizures1.53501100
48MP0000427_abnormal_hair_cycle1.51771872
49MP0008875_abnormal_xenobiotic_pharmacok1.50876396
50MP0002572_abnormal_emotion/affect_behav1.50668667
51MP0008260_abnormal_autophagy1.48004309
52MP0000015_abnormal_ear_pigmentation1.46411360
53MP0002163_abnormal_gland_morphology1.42071493
54MP0002160_abnormal_reproductive_system1.41680462
55MP0004957_abnormal_blastocyst_morpholog1.41554512
56MP0002733_abnormal_thermal_nociception1.41058652
57MP0008932_abnormal_embryonic_tissue1.39889492
58MP0001970_abnormal_pain_threshold1.38256531
59MP0003011_delayed_dark_adaptation1.38177014
60MP0003635_abnormal_synaptic_transmissio1.37925274
61MP0002210_abnormal_sex_determination1.37635575
62MP0004145_abnormal_muscle_electrophysio1.36565657
63MP0005389_reproductive_system_phenotype1.36278907
64MP0005645_abnormal_hypothalamus_physiol1.35840253
65MP0002277_abnormal_respiratory_mucosa1.33227891
66MP0002557_abnormal_social/conspecific_i1.32994145
67MP0001919_abnormal_reproductive_system1.31639752
68MP0002067_abnormal_sensory_capabilities1.31132123
69MP0003136_yellow_coat_color1.29379958
70MP0005174_abnormal_tail_pigmentation1.28927513
71MP0002063_abnormal_learning/memory/cond1.28684961
72MP0000778_abnormal_nervous_system1.26958084
73MP0002734_abnormal_mechanical_nocicepti1.25922865
74MP0002653_abnormal_ependyma_morphology1.23667863
75MP0005386_behavior/neurological_phenoty1.22901293
76MP0004924_abnormal_behavior1.22901293
77MP0003315_abnormal_perineum_morphology1.20504297
78MP0003786_premature_aging1.19785052
79MP0005367_renal/urinary_system_phenotyp1.18881267
80MP0000516_abnormal_urinary_system1.18881267
81MP0002876_abnormal_thyroid_physiology1.17710197
82MP0000372_irregular_coat_pigmentation1.15511135
83MP0000383_abnormal_hair_follicle1.15509517
84MP0005084_abnormal_gallbladder_morpholo1.14900734
85MP0002928_abnormal_bile_duct1.14170602
86MP0005195_abnormal_posterior_eye1.12050813
87MP0002234_abnormal_pharynx_morphology1.09175852
88MP0001905_abnormal_dopamine_level1.08998225
89MP0003646_muscle_fatigue1.07888290
90MP0003890_abnormal_embryonic-extraembry1.07865484
91MP0010386_abnormal_urinary_bladder1.07494875
92MP0002938_white_spotting1.06681534
93MP0001929_abnormal_gametogenesis1.05875740
94MP0000653_abnormal_sex_gland1.05288490
95MP0003937_abnormal_limbs/digits/tail_de1.05197416
96MP0003878_abnormal_ear_physiology1.03322465
97MP0005377_hearing/vestibular/ear_phenot1.03322465
98MP0002697_abnormal_eye_size1.02628657
99MP0002752_abnormal_somatic_nervous1.01707305
100MP0005423_abnormal_somatic_nervous1.01205624
101MP0001485_abnormal_pinna_reflex1.01014182
102MP0002148_abnormal_hypersensitivity_rea0.99626772
103MP0003122_maternal_imprinting0.99386439
104MP0002132_abnormal_respiratory_system0.99241641
105MP0002138_abnormal_hepatobiliary_system0.99195938
106MP0000026_abnormal_inner_ear0.97618768
107MP0002736_abnormal_nociception_after0.97427637
108MP0002127_abnormal_cardiovascular_syste0.96442483
109MP0002184_abnormal_innervation0.95355237
110MP0005248_abnormal_Harderian_gland0.94631192
111MP0001835_abnormal_antigen_presentation0.92155636
112MP0000049_abnormal_middle_ear0.91793593
113MP0003880_abnormal_central_pattern0.90912630
114MP0005167_abnormal_blood-brain_barrier0.90277790
115MP0001286_abnormal_eye_development0.90010520
116MP0004130_abnormal_muscle_cell0.89567866
117MP0002095_abnormal_skin_pigmentation0.89153422
118MP0003137_abnormal_impulse_conducting0.88639919
119MP0001186_pigmentation_phenotype0.88167525
120MP0003699_abnormal_female_reproductive0.88134588
121MP0006276_abnormal_autonomic_nervous0.87892606
122MP0008995_early_reproductive_senescence0.87193841
123MP0001502_abnormal_circadian_rhythm0.86714891
124MP0009053_abnormal_anal_canal0.86378746
125MP0001145_abnormal_male_reproductive0.86324545
126MP0005395_other_phenotype0.85806796
127MP0009785_altered_susceptibility_to0.84038530
128MP0001440_abnormal_grooming_behavior0.83354153
129MP0000613_abnormal_salivary_gland0.82845612
130MP0003755_abnormal_palate_morphology0.82803719
131MP0000678_abnormal_parathyroid_gland0.82716137
132MP0005410_abnormal_fertilization0.82679067
133MP0000230_abnormal_systemic_arterial0.82630900
134MP0001324_abnormal_eye_pigmentation0.82585050
135MP0005379_endocrine/exocrine_gland_phen0.82570669
136MP0000955_abnormal_spinal_cord0.82041981
137MP0002229_neurodegeneration0.82030026
138MP0001984_abnormal_olfaction0.81960690
139MP0002882_abnormal_neuron_morphology0.80965630
140MP0003942_abnormal_urinary_system0.79934873
141MP0000350_abnormal_cell_proliferation0.79302387
142MP0000631_abnormal_neuroendocrine_gland0.76859593
143MP0002396_abnormal_hematopoietic_system0.75170254
144MP0005197_abnormal_uvea_morphology0.75023343
145MP0005193_abnormal_anterior_eye0.74267888
146MP0005451_abnormal_body_composition0.73227476
147MP0003119_abnormal_digestive_system0.73099773
148MP0001529_abnormal_vocalization0.73093100
149MP0005310_abnormal_salivary_gland0.72092712
150MP0005253_abnormal_eye_physiology0.70572251
151MP0001963_abnormal_hearing_physiology0.70097713
152MP0001293_anophthalmia0.69684138
153MP0003938_abnormal_ear_development0.66895655
154MP0002233_abnormal_nose_morphology0.65897423
155MP0001672_abnormal_embryogenesis/_devel0.64255021
156MP0005380_embryogenesis_phenotype0.64255021
157MP0002751_abnormal_autonomic_nervous0.62748646
158MP0003698_abnormal_male_reproductive0.62501129
159MP0001177_atelectasis0.62177725

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.65992221
2Chromsome breakage (HP:0040012)5.32887981
3Congenital stationary night blindness (HP:0007642)4.06655956
4Birth length less than 3rd percentile (HP:0003561)3.88251143
5Nephronophthisis (HP:0000090)3.74659285
6Zonular cataract (HP:0010920)3.55850635
7Nuclear cataract (HP:0100018)3.36809535
8Type II lissencephaly (HP:0007260)3.34182453
9Meckel diverticulum (HP:0002245)3.31832389
10Abnormality of the labia minora (HP:0012880)3.26541025
11Abnormality of the renal medulla (HP:0100957)3.25268394
12Hyperventilation (HP:0002883)3.23613157
13Abnormality of the renal cortex (HP:0011035)3.20844143
14Abnormality of the preputium (HP:0100587)3.18594256
15Abnormality of the ileum (HP:0001549)3.17038178
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.16697998
17Patellar aplasia (HP:0006443)2.98480626
18Pendular nystagmus (HP:0012043)2.98407332
19Progressive cerebellar ataxia (HP:0002073)2.95946640
20Cystic liver disease (HP:0006706)2.94811877
21Genetic anticipation (HP:0003743)2.92754359
22Aplasia/Hypoplasia of the patella (HP:0006498)2.80935576
23Abolished electroretinogram (ERG) (HP:0000550)2.79106234
24Abnormality of chromosome stability (HP:0003220)2.78818495
25Attenuation of retinal blood vessels (HP:0007843)2.78438081
26True hermaphroditism (HP:0010459)2.77199350
27Pancreatic cysts (HP:0001737)2.73338318
28Inability to walk (HP:0002540)2.72993670
29Adrenal hypoplasia (HP:0000835)2.71089735
30Duplicated collecting system (HP:0000081)2.70524855
31Abnormality of the renal collecting system (HP:0004742)2.66301547
32Tubular atrophy (HP:0000092)2.65240862
33Pancreatic fibrosis (HP:0100732)2.64998638
34Embryonal renal neoplasm (HP:0011794)2.64263623
35Nephroblastoma (Wilms tumor) (HP:0002667)2.61871986
36Lissencephaly (HP:0001339)2.57442794
37Hyperalaninemia (HP:0003348)2.57329062
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57329062
39Abnormality of alanine metabolism (HP:0010916)2.57329062
40Gaze-evoked nystagmus (HP:0000640)2.56949991
41Hypoplasia of the fovea (HP:0007750)2.56931486
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.56931486
43Ectopic kidney (HP:0000086)2.53558388
44Sclerocornea (HP:0000647)2.52811080
45Abnormality of midbrain morphology (HP:0002418)2.50849486
46Molar tooth sign on MRI (HP:0002419)2.50849486
47Prostate neoplasm (HP:0100787)2.46726820
48Clubbing of toes (HP:0100760)2.45121169
49Small intestinal stenosis (HP:0012848)2.43201065
50Duodenal stenosis (HP:0100867)2.43201065
51Abnormality of DNA repair (HP:0003254)2.41567168
52Progressive inability to walk (HP:0002505)2.41103952
53Polydipsia (HP:0001959)2.40962672
54Abnormal drinking behavior (HP:0030082)2.40962672
55Keratoconus (HP:0000563)2.37794498
56Increased corneal curvature (HP:0100692)2.37794498
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.34563191
58Cerebellar dysplasia (HP:0007033)2.32947601
59Broad-based gait (HP:0002136)2.30938765
60Median cleft lip (HP:0000161)2.29031650
61Large for gestational age (HP:0001520)2.28971190
62Anencephaly (HP:0002323)2.26449697
63Congenital, generalized hypertrichosis (HP:0004540)2.25503846
64Chorioretinal atrophy (HP:0000533)2.24175176
65Decreased circulating renin level (HP:0003351)2.24021838
66Breast hypoplasia (HP:0003187)2.23612463
67Facial hemangioma (HP:0000329)2.23580378
68Lip pit (HP:0100267)2.21947427
69Occipital encephalocele (HP:0002085)2.21538501
70Furrowed tongue (HP:0000221)2.21491259
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.20235792
72Abnormal hair whorl (HP:0010721)2.19919734
73Abnormal biliary tract physiology (HP:0012439)2.19540581
74Bile duct proliferation (HP:0001408)2.19540581
75Congenital primary aphakia (HP:0007707)2.18803928
76Renal cortical cysts (HP:0000803)2.18691464
77Preaxial hand polydactyly (HP:0001177)2.15694553
78Absent radius (HP:0003974)2.12826625
79Abnormal rod and cone electroretinograms (HP:0008323)2.12328525
80Genital tract atresia (HP:0001827)2.11805684
81Medial flaring of the eyebrow (HP:0010747)2.11605799
82Bone marrow hypocellularity (HP:0005528)2.11462260
83Absent forearm bone (HP:0003953)2.10945577
84Aplasia involving forearm bones (HP:0009822)2.10945577
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10497462
86Concave nail (HP:0001598)2.10388278
87Febrile seizures (HP:0002373)2.10055334
88Recurrent abscess formation (HP:0002722)2.09927014
89Optic nerve hypoplasia (HP:0000609)2.09816534
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.09724570
91Absent/shortened dynein arms (HP:0200106)2.09724570
92Decreased central vision (HP:0007663)2.08816476
93Increased number of teeth (HP:0011069)2.08704314
94Supernumerary spleens (HP:0009799)2.08654354
95Papillary thyroid carcinoma (HP:0002895)2.07446268
96Vaginal atresia (HP:0000148)2.05866467
97Congenital hepatic fibrosis (HP:0002612)2.05823100
98Nephrogenic diabetes insipidus (HP:0009806)2.05667005
99Flat capital femoral epiphysis (HP:0003370)2.05419783
100Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03472364
101Clumsiness (HP:0002312)2.03260710
102Stomach cancer (HP:0012126)2.03173649
103Bony spicule pigmentary retinopathy (HP:0007737)2.03166423
104Bilateral microphthalmos (HP:0007633)2.03112045
105Septo-optic dysplasia (HP:0100842)2.02494366
106Chorioretinal coloboma (HP:0000567)2.01367791
107Retinal dysplasia (HP:0007973)2.01117133
108Abnormality of the pons (HP:0007361)2.00463648
109Abnormality of the carotid arteries (HP:0005344)1.99794480
110Abnormality of the duodenum (HP:0002246)1.99538599
111Hypergonadotropic hypogonadism (HP:0000815)1.98264732
112Capillary hemangiomas (HP:0005306)1.98196424
113Focal motor seizures (HP:0011153)1.96764124
114Hemiparesis (HP:0001269)1.96341347
115Hypoplasia of the pons (HP:0012110)1.94552528
116Myelodysplasia (HP:0002863)1.93789333
117Agnosia (HP:0010524)1.93661192
118Pachygyria (HP:0001302)1.93377222
119Shawl scrotum (HP:0000049)1.93247178
120Abnormality of the fovea (HP:0000493)1.93158819
121Neonatal hypoglycemia (HP:0001998)1.92274613
122Severe muscular hypotonia (HP:0006829)1.91376087
123Oligohydramnios (HP:0001562)1.91246456
124Abnormal respiratory motile cilium morphology (HP:0005938)1.90175571
125Abnormal respiratory epithelium morphology (HP:0012253)1.90175571
126Gait imbalance (HP:0002141)1.90104856
127Focal seizures (HP:0007359)1.89130715
128Abnormality of the prostate (HP:0008775)1.87473222
129Congenital sensorineural hearing impairment (HP:0008527)1.87411354
130Abnormality of cochlea (HP:0000375)1.86879973
131Abnormality of the anterior horn cell (HP:0006802)1.86770377
132Degeneration of anterior horn cells (HP:0002398)1.86770377
133Polyuria (HP:0000103)1.85776494
134Bifid tongue (HP:0010297)1.85042451
135Sloping forehead (HP:0000340)1.84820919
136Morphological abnormality of the inner ear (HP:0011390)1.84791818
137Recurrent bacterial skin infections (HP:0005406)1.82759146
138Medulloblastoma (HP:0002885)1.82459611
139Duplication of thumb phalanx (HP:0009942)1.80956484
140Rectal fistula (HP:0100590)1.80575438
141Rectovaginal fistula (HP:0000143)1.80575438
142Hypothermia (HP:0002045)1.79626256
143Oligodactyly (hands) (HP:0001180)1.79164459
144Male pseudohermaphroditism (HP:0000037)1.78392222
145Postaxial foot polydactyly (HP:0001830)1.78067985
146Small hand (HP:0200055)1.77991252
147Poor coordination (HP:0002370)1.77567417
148Dandy-Walker malformation (HP:0001305)1.75991240
149Triphalangeal thumb (HP:0001199)1.75192426
150Breast aplasia (HP:0100783)1.74972221
151Abnormal ciliary motility (HP:0012262)1.73106264
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73032226
153Aganglionic megacolon (HP:0002251)1.72823182
154Fair hair (HP:0002286)1.72737195
155Chronic hepatic failure (HP:0100626)1.72659526
156Absent speech (HP:0001344)1.72321546
157Anophthalmia (HP:0000528)1.72198166
158Horseshoe kidney (HP:0000085)1.71615240
159Agitation (HP:0000713)1.71360470
160Thyroid-stimulating hormone excess (HP:0002925)1.70527110
161Aplasia/Hypoplasia of the sternum (HP:0006714)1.69181683
162Neoplasm of the adrenal cortex (HP:0100641)1.69087960
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68736340
164Dialeptic seizures (HP:0011146)1.68059195
165Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67340023
166Short thumb (HP:0009778)1.66768732
167Optic nerve coloboma (HP:0000588)1.66748714
168Intestinal fistula (HP:0100819)1.65981291
169Methylmalonic acidemia (HP:0002912)1.65814653
170Optic neuritis (HP:0100653)1.64600078
171Retrobulbar optic neuritis (HP:0100654)1.64600078
172Protruding tongue (HP:0010808)1.60605326
173Intestinal atresia (HP:0011100)1.60516127
174Tracheoesophageal fistula (HP:0002575)1.60057260
175Aplasia/Hypoplasia of the breasts (HP:0010311)1.59939464
176Absent thumb (HP:0009777)1.58590733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR22.94023677
2PLK42.80103358
3AKT32.78288824
4WNK32.77480087
5STK38L2.69802548
6MAPK132.58878011
7ZAK2.53714057
8MAP4K22.37393839
9CASK2.34463049
10INSRR2.32893503
11TLK12.29696003
12WNK42.27601707
13BUB12.26419875
14STK162.26025177
15EPHA22.13442625
16ERBB32.03642585
17CDK81.95620948
18PRPF4B1.93837507
19MAP2K71.89938340
20EIF2AK11.84491767
21SRPK11.81601233
22BRAF1.75402460
23PLK31.73119083
24NEK61.70008646
25SIK31.68909230
26DAPK21.67970724
27VRK11.67535155
28OXSR11.62354412
29PLK21.58327173
30IRAK41.57702716
31TTK1.56757431
32IRAK31.56575260
33MAP3K141.55266621
34TXK1.53122608
35TSSK61.49875814
36EIF2AK21.47243284
37NUAK11.42886822
38CDC71.42229688
39PNCK1.42094025
40WEE11.38247389
41TGFBR11.37126402
42STK391.35165743
43PLK11.33356905
44ADRBK11.33275647
45DYRK21.29900125
46SGK21.27401775
47MKNK21.24004787
48CHEK21.18984727
49STK241.18407913
50NEK91.15560351
51NTRK31.14586320
52YES11.10960074
53CCNB11.09620383
54PAK31.07760543
55PRKCG1.05555305
56NLK1.05249909
57PDK21.04098761
58BCR1.03994711
59STK30.99141909
60NTRK20.98134599
61MKNK10.95485571
62SIK20.94240505
63ATR0.93179641
64PINK10.92213736
65MAPK150.89960088
66CAMKK20.87330537
67ADRBK20.86942386
68JAK30.85930153
69NME20.85784885
70BMPR1B0.85180805
71TRIM280.84891516
72PBK0.79064960
73MARK10.77851007
74PHKG10.77467111
75PHKG20.77467111
76BRSK20.77396905
77NEK20.76464406
78CSNK1G20.75566359
79FGFR20.74941652
80CDK30.72927011
81TIE10.72552730
82GRK70.71642064
83AURKB0.70319870
84PIK3CA0.70100291
85MAP3K60.68730984
86TAOK20.67889923
87TAOK30.67562363
88DYRK1A0.64603271
89LATS20.63882513
90MAPKAPK50.62925915
91TEC0.62864707
92PTK2B0.62760351
93AURKA0.62753809
94EIF2AK30.62398665
95LATS10.61842086
96CSNK1G10.61763050
97PKN10.61590181
98ERBB40.61458406
99MELK0.61405255
100DYRK30.59421585
101CAMK2A0.58993884
102MAP2K60.58774263
103CDK70.57159447
104CSNK1G30.56105870
105EPHA40.56080487
106KSR10.55701661
107BCKDK0.55362709
108SGK30.54632865
109MAPKAPK30.54504142
110PRKCI0.54425187
111CAMK10.53367160
112RPS6KA50.53257948
113CSNK1A1L0.51526200
114RIPK40.51433271
115SGK4940.50220724
116SGK2230.50220724
117NME10.49438813
118STK110.49431914
119ATM0.49062777
120CLK10.48595474
121ACVR1B0.48427424
122GRK10.48038750
123CDK190.47950722
124CHUK0.47042543
125CHEK10.45489086
126MUSK0.45095457
127PRKACA0.45025159
128PRKCQ0.44569098
129RPS6KB10.43730169
130PRKCE0.42044498
131CSNK1A10.41917721
132ERBB20.41534286
133IKBKB0.40885287
134STK40.40527924
135CSNK1D0.40187422
136OBSCN0.39219574
137IRAK10.38632516
138CDK10.38469814
139PRKCZ0.37947323
140PRKAA10.37265760
141MAP3K40.36285453
142CSNK2A10.36118258
143TNIK0.35954110
144MOS0.35701544
145ARAF0.35313608
146TAF10.35213047
147EPHA30.34589222
148FRK0.34564592
149CAMK40.34032475
150CDK20.33485126
151MAP2K40.32869782
152PRKAA20.31181669
153FLT30.31052371
154KIT0.31050084
155PRKG10.30587991
156PRKCA0.30535723
157MAP3K70.30236851

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.10808310
2Homologous recombination_Homo sapiens_hsa034402.96742843
3Basal transcription factors_Homo sapiens_hsa030222.79694734
4RNA polymerase_Homo sapiens_hsa030202.79604572
5Base excision repair_Homo sapiens_hsa034102.71618402
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71239854
7Linoleic acid metabolism_Homo sapiens_hsa005912.64295413
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62578257
9Nitrogen metabolism_Homo sapiens_hsa009102.56374288
10DNA replication_Homo sapiens_hsa030302.56094603
11Mismatch repair_Homo sapiens_hsa034302.46971420
12Cell cycle_Homo sapiens_hsa041102.42119633
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39138416
14Nucleotide excision repair_Homo sapiens_hsa034202.29355800
15Butanoate metabolism_Homo sapiens_hsa006502.23471338
16Proteasome_Homo sapiens_hsa030502.19221611
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17461946
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14757359
19Non-homologous end-joining_Homo sapiens_hsa034502.06298806
20RNA degradation_Homo sapiens_hsa030182.05325404
21Selenocompound metabolism_Homo sapiens_hsa004502.02049394
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98669938
23Tryptophan metabolism_Homo sapiens_hsa003801.88576440
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85663427
25Oxidative phosphorylation_Homo sapiens_hsa001901.83839894
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.81147214
27Pyrimidine metabolism_Homo sapiens_hsa002401.76738297
28Caffeine metabolism_Homo sapiens_hsa002321.73053934
29RNA transport_Homo sapiens_hsa030131.67688828
30Graft-versus-host disease_Homo sapiens_hsa053321.47558849
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46793248
32Nicotine addiction_Homo sapiens_hsa050331.44989655
33Spliceosome_Homo sapiens_hsa030401.40511946
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40253342
35Parkinsons disease_Homo sapiens_hsa050121.40172102
36Type I diabetes mellitus_Homo sapiens_hsa049401.38554652
37One carbon pool by folate_Homo sapiens_hsa006701.34628897
38GABAergic synapse_Homo sapiens_hsa047271.34518638
39ABC transporters_Homo sapiens_hsa020101.33988364
40Purine metabolism_Homo sapiens_hsa002301.30230953
41Circadian entrainment_Homo sapiens_hsa047131.24475266
42mRNA surveillance pathway_Homo sapiens_hsa030151.21430237
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.21007328
44Allograft rejection_Homo sapiens_hsa053301.19219925
45p53 signaling pathway_Homo sapiens_hsa041151.18402580
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16904364
47Cardiac muscle contraction_Homo sapiens_hsa042601.16081759
48Insulin secretion_Homo sapiens_hsa049111.11813472
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.11110746
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11035024
51Herpes simplex infection_Homo sapiens_hsa051681.10660431
52Regulation of autophagy_Homo sapiens_hsa041401.10224501
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08792235
54Rheumatoid arthritis_Homo sapiens_hsa053231.06376495
55Chemical carcinogenesis_Homo sapiens_hsa052041.05730125
56Propanoate metabolism_Homo sapiens_hsa006401.05449992
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04739451
58Epstein-Barr virus infection_Homo sapiens_hsa051691.03172319
59Huntingtons disease_Homo sapiens_hsa050161.00022677
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98484178
61Peroxisome_Homo sapiens_hsa041460.97516733
62Oocyte meiosis_Homo sapiens_hsa041140.97382003
63Circadian rhythm_Homo sapiens_hsa047100.94402070
64Retinol metabolism_Homo sapiens_hsa008300.92218071
65Alzheimers disease_Homo sapiens_hsa050100.91182183
66Legionellosis_Homo sapiens_hsa051340.90518316
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.88766861
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88453638
69Autoimmune thyroid disease_Homo sapiens_hsa053200.87891545
70Calcium signaling pathway_Homo sapiens_hsa040200.86669817
71Ovarian steroidogenesis_Homo sapiens_hsa049130.85209645
72Glycerolipid metabolism_Homo sapiens_hsa005610.84730088
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84678454
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83080590
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83010302
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82722669
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.79989778
78Influenza A_Homo sapiens_hsa051640.79079109
79Arachidonic acid metabolism_Homo sapiens_hsa005900.77236805
80Salivary secretion_Homo sapiens_hsa049700.75841702
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73631173
82Dorso-ventral axis formation_Homo sapiens_hsa043200.73162836
83Fat digestion and absorption_Homo sapiens_hsa049750.72672529
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70436047
85Measles_Homo sapiens_hsa051620.70363398
86Dopaminergic synapse_Homo sapiens_hsa047280.70308593
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70006398
88Histidine metabolism_Homo sapiens_hsa003400.69182899
89Olfactory transduction_Homo sapiens_hsa047400.69122437
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67692593
91Phagosome_Homo sapiens_hsa041450.67602581
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67389260
93beta-Alanine metabolism_Homo sapiens_hsa004100.67189985
94TGF-beta signaling pathway_Homo sapiens_hsa043500.67015901
95Taste transduction_Homo sapiens_hsa047420.66768795
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65906684
97Long-term depression_Homo sapiens_hsa047300.65770475
98Hippo signaling pathway_Homo sapiens_hsa043900.64901542
99Protein export_Homo sapiens_hsa030600.63609697
100Cocaine addiction_Homo sapiens_hsa050300.62042130
101Collecting duct acid secretion_Homo sapiens_hsa049660.61259667
102Sphingolipid metabolism_Homo sapiens_hsa006000.60809304
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60720954
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59570767
105FoxO signaling pathway_Homo sapiens_hsa040680.59433993
106HTLV-I infection_Homo sapiens_hsa051660.58783487
107Serotonergic synapse_Homo sapiens_hsa047260.58508818
108Basal cell carcinoma_Homo sapiens_hsa052170.58136872
109Other glycan degradation_Homo sapiens_hsa005110.58070823
110Asthma_Homo sapiens_hsa053100.57486848
111African trypanosomiasis_Homo sapiens_hsa051430.56860243
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56575560
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56353583
114Cholinergic synapse_Homo sapiens_hsa047250.56099806
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55697715
116Hedgehog signaling pathway_Homo sapiens_hsa043400.54240094
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.54109981
118Leishmaniasis_Homo sapiens_hsa051400.53994557
119Synaptic vesicle cycle_Homo sapiens_hsa047210.53449484
120Sulfur relay system_Homo sapiens_hsa041220.52103520
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51077604
122MicroRNAs in cancer_Homo sapiens_hsa052060.50626041
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49020223
124Morphine addiction_Homo sapiens_hsa050320.48415606
125Ether lipid metabolism_Homo sapiens_hsa005650.48383693
126Metabolic pathways_Homo sapiens_hsa011000.47718879
127TNF signaling pathway_Homo sapiens_hsa046680.47303780
128Amphetamine addiction_Homo sapiens_hsa050310.46627014
129cAMP signaling pathway_Homo sapiens_hsa040240.46421500
130Oxytocin signaling pathway_Homo sapiens_hsa049210.46372441
131Vitamin digestion and absorption_Homo sapiens_hsa049770.46313961
132Wnt signaling pathway_Homo sapiens_hsa043100.45254225
133Fatty acid biosynthesis_Homo sapiens_hsa000610.45116054
134Endometrial cancer_Homo sapiens_hsa052130.45019683
135Hematopoietic cell lineage_Homo sapiens_hsa046400.44319800
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42717043
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42671942
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.42371559
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42344690
140Mineral absorption_Homo sapiens_hsa049780.42046513
141Tuberculosis_Homo sapiens_hsa051520.41486633
142Primary immunodeficiency_Homo sapiens_hsa053400.41399139
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40534649
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40100631
145Axon guidance_Homo sapiens_hsa043600.40092357
146Viral carcinogenesis_Homo sapiens_hsa052030.40080504
147Hepatitis B_Homo sapiens_hsa051610.39974737
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.39292468
149Prolactin signaling pathway_Homo sapiens_hsa049170.38821347
150Colorectal cancer_Homo sapiens_hsa052100.38751502
151Sulfur metabolism_Homo sapiens_hsa009200.38499220
152Gastric acid secretion_Homo sapiens_hsa049710.37469485
153Vitamin B6 metabolism_Homo sapiens_hsa007500.37137920
154Apoptosis_Homo sapiens_hsa042100.37129319
155Phototransduction_Homo sapiens_hsa047440.36718155
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36501561
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35263304
158Adherens junction_Homo sapiens_hsa045200.34965534
159Glutamatergic synapse_Homo sapiens_hsa047240.33473495
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32033005
161Chemokine signaling pathway_Homo sapiens_hsa040620.31231843
162Melanoma_Homo sapiens_hsa052180.31129827

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