ZBTB8OSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein polyubiquitination (GO:1902914)9.01563264
2catecholamine transport (GO:0051937)7.98730847
3neurotransmitter uptake (GO:0001504)7.47633484
4negative regulation of actin filament bundle assembly (GO:0032232)7.38540019
5regulation of mitochondrial fission (GO:0090140)7.32235715
6startle response (GO:0001964)7.11647739
7norepinephrine metabolic process (GO:0042415)7.10428873
8response to manganese ion (GO:0010042)6.46748200
9regulation of type B pancreatic cell apoptotic process (GO:2000674)6.27372206
10zinc ion homeostasis (GO:0055069)5.88156203
11regulation of mitochondrial translation (GO:0070129)5.85341155
12regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)5.79331401
13L-fucose catabolic process (GO:0042355)5.31552861
14fucose catabolic process (GO:0019317)5.31552861
15L-fucose metabolic process (GO:0042354)5.31552861
16cellular response to ammonium ion (GO:0071242)5.29722978
17monoamine transport (GO:0015844)5.20606923
18cellular response to catecholamine stimulus (GO:0071870)4.55590580
19cellular response to monoamine stimulus (GO:0071868)4.55590580
20regulation of dopamine secretion (GO:0014059)4.54788552
21negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)4.40316704
22regulation of actin nucleation (GO:0051125)4.38321575
23mitochondrion degradation (GO:0000422)4.35588773
24cellular response to toxic substance (GO:0097237)4.11334398
25cellular protein catabolic process (GO:0044257)4.06288298
26intra-S DNA damage checkpoint (GO:0031573)4.04112929
27phenylpropanoid metabolic process (GO:0009698)3.96724147
28positive regulation of DNA binding (GO:0043388)3.94882382
29response to monoamine (GO:0071867)3.93606526
30response to catecholamine (GO:0071869)3.93606526
31negative regulation of cellular carbohydrate metabolic process (GO:0010677)3.92399615
32apical protein localization (GO:0045176)3.88136156
33negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.84443691
34regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.80575979
35negative regulation of reactive oxygen species metabolic process (GO:2000378)3.66899647
36response to pheromone (GO:0019236)3.58340805
37nitric oxide mediated signal transduction (GO:0007263)3.56840845
38dopamine metabolic process (GO:0042417)3.53676965
39platelet dense granule organization (GO:0060155)3.52838339
40xenobiotic catabolic process (GO:0042178)3.51475542
41protein import into peroxisome matrix (GO:0016558)3.49909507
42neuromuscular process controlling posture (GO:0050884)3.46484174
43mitochondrial fission (GO:0000266)3.41050528
44nitric oxide biosynthetic process (GO:0006809)3.34706855
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31801241
46positive regulation of cytokine-mediated signaling pathway (GO:0001961)3.20152870
47negative regulation of carbohydrate metabolic process (GO:0045912)3.19134589
48interkinetic nuclear migration (GO:0022027)3.17029150
49positive regulation of response to cytokine stimulus (GO:0060760)3.11492555
50protein K63-linked ubiquitination (GO:0070534)3.03748516
51pteridine-containing compound biosynthetic process (GO:0042559)2.96135281
52negative regulation of insulin secretion (GO:0046676)2.92240983
53cellular response to interferon-beta (GO:0035458)2.87497817
54regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.85269661
55regulation of glycogen (starch) synthase activity (GO:2000465)2.85011820
56endocrine pancreas development (GO:0031018)2.78580133
57signal peptide processing (GO:0006465)2.77690131
58folic acid-containing compound biosynthetic process (GO:0009396)2.75677914
59cellular response to vitamin D (GO:0071305)2.73856593
60DNA deamination (GO:0045006)2.72519533
61regulation of catecholamine secretion (GO:0050433)2.71095424
62protein prenylation (GO:0018342)2.70099457
63prenylation (GO:0097354)2.70099457
64detection of light stimulus involved in visual perception (GO:0050908)2.69160766
65detection of light stimulus involved in sensory perception (GO:0050962)2.69160766
66peptidyl-histidine modification (GO:0018202)2.68734336
67positive regulation of lamellipodium organization (GO:1902745)2.68430041
68aspartate family amino acid catabolic process (GO:0009068)2.64691964
69protein autoubiquitination (GO:0051865)2.64598055
70grooming behavior (GO:0007625)2.64584257
71rRNA catabolic process (GO:0016075)2.62634683
72negative regulation of peptide hormone secretion (GO:0090278)2.61968885
73negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.61765269
74positive regulation of lamellipodium assembly (GO:0010592)2.60719142
75cytochrome complex assembly (GO:0017004)2.55672481
76negative regulation of gluconeogenesis (GO:0045721)2.55276500
77chemosensory behavior (GO:0007635)2.54279600
78C4-dicarboxylate transport (GO:0015740)2.54176195
79negative regulation of peptide secretion (GO:0002792)2.52284647
80regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51109144
81regulation of synaptic vesicle transport (GO:1902803)2.50061373
82S-adenosylmethionine metabolic process (GO:0046500)2.49088669
83positive regulation of transcription regulatory region DNA binding (GO:2000679)2.47326992
84fucose metabolic process (GO:0006004)2.46397888
85cellular response to hepatocyte growth factor stimulus (GO:0035729)2.46245171
86response to hepatocyte growth factor (GO:0035728)2.46245171
87piRNA metabolic process (GO:0034587)2.45102595
88body morphogenesis (GO:0010171)2.42923367
89negative regulation of oxidative stress-induced cell death (GO:1903202)2.42580488
90hyperosmotic response (GO:0006972)2.41540884
91regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.41235319
92potassium ion export (GO:0071435)2.40601867
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38911361
94regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:190223512.5608126
95protein K6-linked ubiquitination (GO:0085020)12.4516690
96regulation of glucokinase activity (GO:0033131)11.4741330
97regulation of hexokinase activity (GO:1903299)11.4741330
98dopamine transport (GO:0015872)10.8391336
99regulation of oxidative stress-induced neuron death (GO:1903203)10.2913888
100positive regulation of mitochondrial fission (GO:0090141)10.0737568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.58046456
2GATA1_22025678_ChIP-Seq_K562_Human4.39743502
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77882676
4VDR_22108803_ChIP-Seq_LS180_Human2.84132812
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.66896118
6ZNF274_21170338_ChIP-Seq_K562_Hela2.63106483
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.55378082
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50513765
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.50406684
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42566259
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.40349869
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.32447349
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.31913961
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19812401
15ELK1_19687146_ChIP-ChIP_HELA_Human2.09156684
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08026307
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07251873
18BCAT_22108803_ChIP-Seq_LS180_Human2.01782167
19IGF1R_20145208_ChIP-Seq_DFB_Human1.98011330
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95861313
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92388087
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92367069
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80356039
24P300_19829295_ChIP-Seq_ESCs_Human1.79249272
25ER_23166858_ChIP-Seq_MCF-7_Human1.78026900
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71284663
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61810382
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61079021
29EWS_26573619_Chip-Seq_HEK293_Human1.58970944
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.58024823
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56729888
32AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54602065
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.53061756
34CBP_20019798_ChIP-Seq_JUKART_Human1.52988326
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52988326
36NCOR_22424771_ChIP-Seq_293T_Human1.52708663
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51661039
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50191043
39TCF4_22108803_ChIP-Seq_LS180_Human1.47128320
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46361785
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43381282
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41593563
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.39066196
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38548422
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34795294
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34153920
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31349129
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.31121005
49CDX2_22108803_ChIP-Seq_LS180_Human1.29237158
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.26616333
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26493257
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.25591770
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25449302
54P53_22387025_ChIP-Seq_ESCs_Mouse1.24645660
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24377654
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.24190504
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23851877
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21672138
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.21621624
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.20560872
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20214035
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19976771
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.17271275
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16934390
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16891128
66SMAD4_21799915_ChIP-Seq_A2780_Human1.16342176
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.14287788
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14287788
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14239173
70NANOG_19829295_ChIP-Seq_ESCs_Human1.13164573
71SOX2_19829295_ChIP-Seq_ESCs_Human1.13164573
72TCF4_23295773_ChIP-Seq_U87_Human1.12674593
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.12666516
74STAT3_23295773_ChIP-Seq_U87_Human1.12510189
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10523137
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10035433
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.09593001
78P300_18555785_Chip-Seq_ESCs_Mouse1.07438281
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.07086993
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.06774746
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06675488
82AR_25329375_ChIP-Seq_VCAP_Human1.06443126
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04955763
84ERG_20517297_ChIP-Seq_VCAP_Human1.04620974
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.04510789
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.04172387
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04108624
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03620210
89RBPJ_21746931_ChIP-Seq_IB4_Human1.03146335
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02834661
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.01402264
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00948061
93VDR_23849224_ChIP-Seq_CD4+_Human1.00813858
94FOXH1_21741376_ChIP-Seq_EPCs_Human1.00312569
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.00183635
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00118883
97FUS_26573619_Chip-Seq_HEK293_Human0.98528413
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97284632
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96893102
100ETV1_20927104_ChIP-Seq_GIST48_Human0.96520421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.77695147
2MP0003195_calcinosis4.60499685
3MP0003283_abnormal_digestive_organ3.54039502
4MP0008995_early_reproductive_senescence3.46912937
5MP0005423_abnormal_somatic_nervous3.24717952
6MP0005379_endocrine/exocrine_gland_phen3.22658555
7MP0006072_abnormal_retinal_apoptosis2.94260770
8MP0005646_abnormal_pituitary_gland2.85873667
9MP0003879_abnormal_hair_cell2.79715792
10MP0003172_abnormal_lysosome_physiology2.78064742
11MP0003300_gastrointestinal_ulcer2.64722808
12MP0003787_abnormal_imprinting2.41596744
13MP0006035_abnormal_mitochondrial_morpho2.40875364
14MP0006036_abnormal_mitochondrial_physio2.35453482
15MP0005220_abnormal_exocrine_pancreas2.35421254
16MP0003186_abnormal_redox_activity2.30799058
17MP0004885_abnormal_endolymph2.24462208
18MP0001485_abnormal_pinna_reflex2.21791646
19MP0003123_paternal_imprinting2.15595815
20MP0001905_abnormal_dopamine_level1.97774724
21MP0006292_abnormal_olfactory_placode1.97182116
22MP0002909_abnormal_adrenal_gland1.93055921
23MP0003806_abnormal_nucleotide_metabolis1.84926104
24MP0005645_abnormal_hypothalamus_physiol1.71744463
25MP0004147_increased_porphyrin_level1.65356019
26MP0009785_altered_susceptibility_to1.65037635
27MP0002272_abnormal_nervous_system1.63981161
28MP0008004_abnormal_stomach_pH1.63246049
29MP0000470_abnormal_stomach_morphology1.57725916
30MP0005365_abnormal_bile_salt1.49905789
31MP0009333_abnormal_splenocyte_physiolog1.48536314
32MP0001873_stomach_inflammation1.48208502
33MP0001666_abnormal_nutrient_absorption1.47658708
34MP0005167_abnormal_blood-brain_barrier1.47240400
35MP0009764_decreased_sensitivity_to1.44880600
36MP0005075_abnormal_melanosome_morpholog1.42026720
37MP0005671_abnormal_response_to1.41853070
38MP0001944_abnormal_pancreas_morphology1.41704147
39MP0002653_abnormal_ependyma_morphology1.41210009
40MP0002693_abnormal_pancreas_physiology1.40225719
41MP0005084_abnormal_gallbladder_morpholo1.38687481
42MP0000015_abnormal_ear_pigmentation1.33450508
43MP0003866_abnormal_defecation1.33294036
44MP0008775_abnormal_heart_ventricle1.32060665
45MP0003786_premature_aging1.32059642
46MP0006054_spinal_hemorrhage1.27444693
47MP0002163_abnormal_gland_morphology1.25210558
48MP0005410_abnormal_fertilization1.24513038
49MP0001664_abnormal_digestion1.23541399
50MP0005535_abnormal_body_temperature1.19955523
51MP0002837_dystrophic_cardiac_calcinosis1.19428898
52MP0005083_abnormal_biliary_tract1.18013151
53MP0005551_abnormal_eye_electrophysiolog1.16748175
54MP0009745_abnormal_behavioral_response1.14981259
55MP0001986_abnormal_taste_sensitivity1.07450205
56MP0004381_abnormal_hair_follicle1.07118921
57MP0002229_neurodegeneration1.06588357
58MP0008872_abnormal_physiological_respon1.06468802
59MP0003959_abnormal_lean_body1.04566414
60MP0005647_abnormal_sex_gland1.01031829
61MP0002928_abnormal_bile_duct0.99809475
62MP0001835_abnormal_antigen_presentation0.98050537
63MP0005253_abnormal_eye_physiology0.97158193
64MP0001188_hyperpigmentation0.96329593
65MP0005332_abnormal_amino_acid0.95275999
66MP0001486_abnormal_startle_reflex0.93881509
67MP0003137_abnormal_impulse_conducting0.90789049
68MP0003633_abnormal_nervous_system0.89573893
69MP0002078_abnormal_glucose_homeostasis0.85791501
70MP0001440_abnormal_grooming_behavior0.84697097
71MP0000343_altered_response_to0.84618161
72MP0003953_abnormal_hormone_level0.82288384
73MP0001845_abnormal_inflammatory_respons0.81047610
74MP0002148_abnormal_hypersensitivity_rea0.80442884
75MP0003119_abnormal_digestive_system0.80335465
76MP0000462_abnormal_digestive_system0.80219965
77MP0000749_muscle_degeneration0.80164355
78MP0004084_abnormal_cardiac_muscle0.78677328
79MP0010155_abnormal_intestine_physiology0.78309331
80MP0005025_abnormal_response_to0.76255712
81MP0002572_abnormal_emotion/affect_behav0.74324664
82MP0002638_abnormal_pupillary_reflex0.72434044
83MP0002210_abnormal_sex_determination0.72430225
84MP0005187_abnormal_penis_morphology0.72107483
85MP0001501_abnormal_sleep_pattern0.71918877
86MP0003698_abnormal_male_reproductive0.70145347
87MP0001661_extended_life_span0.70051338
88MP0003950_abnormal_plasma_membrane0.69979692
89MP0009643_abnormal_urine_homeostasis0.69129399
90MP0000427_abnormal_hair_cycle0.68632102
91MP0009765_abnormal_xenobiotic_induced0.66849291
92MP0000465_gastrointestinal_hemorrhage0.66155666
93MP0010329_abnormal_lipoprotein_level0.64330927
94MP0002166_altered_tumor_susceptibility0.64271887
95MP0000358_abnormal_cell_content/0.64198278
96MP0001984_abnormal_olfaction0.63548448
97MP0005448_abnormal_energy_balance0.63382853
98MP0009697_abnormal_copulation0.62545796
99MP0004130_abnormal_muscle_cell0.60372894
100MP0001145_abnormal_male_reproductive0.59953139

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)8.64508227
2Hypoplasia of the fovea (HP:0007750)8.64508227
3Anterior segment dysgenesis (HP:0007700)7.93217173
4Abnormality of the fovea (HP:0000493)6.89834595
5Alveolar cell carcinoma (HP:0006519)5.88153911
6Aplasia/Hypoplasia of the macula (HP:0008059)5.70373956
7Germ cell neoplasia (HP:0100728)5.42674791
8Neoplasm of the tracheobronchial system (HP:0100552)5.32546479
9Aplasia/Hypoplasia affecting the retina (HP:0008061)5.30339146
10Genetic anticipation (HP:0003743)4.92912720
11Hyperinsulinemic hypoglycemia (HP:0000825)4.30601141
12Hypoglycemic seizures (HP:0002173)3.85705000
13Abnormal pancreas size (HP:0012094)3.83727997
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.63810559
15Breast carcinoma (HP:0003002)3.49884578
16Scanning speech (HP:0002168)3.35477409
17Autoimmune hemolytic anemia (HP:0001890)3.31636927
18Stomatitis (HP:0010280)3.16308181
19Methylmalonic acidemia (HP:0002912)3.08908156
20Postural instability (HP:0002172)3.04899770
21Abnormal drinking behavior (HP:0030082)3.04681379
22Polydipsia (HP:0001959)3.04681379
23Abnormality of homocysteine metabolism (HP:0010919)2.99422626
24Homocystinuria (HP:0002156)2.99422626
25Abnormality of B cell number (HP:0010975)2.99389439
26Hypoglycemic coma (HP:0001325)2.97464351
27Polyuria (HP:0000103)2.94730039
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.83647175
29Dysmetric saccades (HP:0000641)2.80777431
30Progressive cerebellar ataxia (HP:0002073)2.76693300
31Abnormality of the anterior chamber (HP:0000593)2.76414864
32Abnormality of the line of Schwalbe (HP:0008048)2.73344140
33Posterior embryotoxon (HP:0000627)2.71012851
34Albinism (HP:0001022)2.65716302
35Rectovaginal fistula (HP:0000143)2.60462544
36Rectal fistula (HP:0100590)2.60462544
37Agitation (HP:0000713)2.57315992
38Symptomatic seizures (HP:0011145)2.53679247
39Abnormality of the vitamin B12 metabolism (HP:0004341)2.53587510
40Febrile seizures (HP:0002373)2.52881807
41Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.48317189
42Severe muscular hypotonia (HP:0006829)2.47733302
43Abnormality of vitamin B metabolism (HP:0004340)2.44557832
44Late onset (HP:0003584)2.43928616
45Limb hypertonia (HP:0002509)2.42722871
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41704667
47Increased hepatocellular lipid droplets (HP:0006565)2.39569699
48Hypothermia (HP:0002045)2.38277110
49Abnormal urine output (HP:0012590)2.37929549
50Gaze-evoked nystagmus (HP:0000640)2.36565361
51Abnormality of the parathyroid morphology (HP:0011766)2.32978946
52Lipid accumulation in hepatocytes (HP:0006561)2.31555691
53Thyroiditis (HP:0100646)2.27537771
54Increased circulating renin level (HP:0000848)2.26787256
55Abnormality of calcium-phosphate metabolism (HP:0100530)2.24508688
56Abnormality of methionine metabolism (HP:0010901)2.23420619
57Medial flaring of the eyebrow (HP:0010747)2.23288733
58Congenital stationary night blindness (HP:0007642)2.17619310
59Methylmalonic aciduria (HP:0012120)2.16479925
60Intestinal fistula (HP:0100819)2.14089515
61Abnormal rod and cone electroretinograms (HP:0008323)2.11770214
62Insulin-resistant diabetes mellitus (HP:0000831)2.09963397
63Vaginal fistula (HP:0004320)2.04564967
64Abnormality of renal excretion (HP:0011036)2.04529924
65B lymphocytopenia (HP:0010976)2.03166220
66Increased IgM level (HP:0003496)2.02922986
67Hyperglycemia (HP:0003074)2.01550717
68Congenital, generalized hypertrichosis (HP:0004540)2.00751938
69Azoospermia (HP:0000027)1.97993591
70Neoplasm of the lung (HP:0100526)1.97707808
71Molar tooth sign on MRI (HP:0002419)1.96782954
72Abnormality of midbrain morphology (HP:0002418)1.96782954
73Abnormality of saccadic eye movements (HP:0000570)1.96028495
74Urinary bladder sphincter dysfunction (HP:0002839)1.94879477
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94481961
76Abnormality of vitamin metabolism (HP:0100508)1.92035784
77Abnormality of lateral ventricle (HP:0030047)1.88811970
78Elevated erythrocyte sedimentation rate (HP:0003565)1.86176394
79Tubular atrophy (HP:0000092)1.84892307
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84832342
81Esotropia (HP:0000565)1.84457647
82Tachypnea (HP:0002789)1.84243220
83Brushfield spots (HP:0001088)1.83779599
84Steatorrhea (HP:0002570)1.82342567
85Severe combined immunodeficiency (HP:0004430)1.79462815
86Neoplasm of the respiratory system (HP:0100606)1.77818203
87Hypoproteinemia (HP:0003075)1.76550936
88Ovarian neoplasm (HP:0100615)1.76493498
89Restlessness (HP:0000711)1.74203573
90Slow saccadic eye movements (HP:0000514)1.73812122
91Tubulointerstitial fibrosis (HP:0005576)1.72329835
92Eosinophilia (HP:0001880)1.71589707
93Hyperventilation (HP:0002883)1.67797996
94Tongue fasciculations (HP:0001308)1.67110029
95Abnormality of eosinophils (HP:0001879)1.65634019
96Disproportionate short-trunk short stature (HP:0003521)1.63521948
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63293430
98Dysdiadochokinesis (HP:0002075)1.63238952
993-Methylglutaconic aciduria (HP:0003535)1.62881061
100Increased CSF lactate (HP:0002490)1.62364886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK2.95803231
2TESK22.74829260
3FRK2.35745062
4CASK2.28087012
5EIF2AK32.19310344
6STK102.03339029
7PINK112.6329621
8NUAK11.88537624
9PIK3CA1.83360599
10EIF2AK11.75286909
11TRIM281.65803311
12KSR11.64326528
13MST41.63278520
14MARK31.51219552
15ADRBK21.48923323
16GRK11.35571852
17TAOK31.31369581
18AKT31.28647455
19PTK2B1.23924678
20DYRK31.22802859
21LRRK21.21856279
22MAPKAPK31.14046452
23ZAK1.11407367
24TSSK61.10828572
25TXK1.09700388
26STK31.09216920
27SIK31.07362573
28RPS6KB21.02460194
29IKBKE1.01494077
30STK390.98074608
31BMPR1B0.87068461
32SGK20.86450461
33OXSR10.85844331
34FER0.83063979
35GRK70.79181476
36TYK20.78537778
37ITK0.76453710
38WNK30.74088317
39TBK10.72933655
40PRKCI0.66550668
41STK38L0.65821195
42SGK2230.64534571
43SGK4940.64534571
44JAK30.63959389
45TEC0.62816130
46CLK10.61497494
47BCR0.56914709
48CDC42BPA0.53384379
49STK40.51420274
50STK110.51007639
51ADRBK10.50518325
52PRKCQ0.49065073
53VRK10.48111437
54MINK10.47615040
55KDR0.46342505
56PAK30.44867248
57NLK0.43429341
58PLK30.42073567
59ERBB30.41641167
60NEK10.41408606
61PRKCG0.40623573
62CDK80.39008772
63HIPK20.37465002
64SGK30.37378180
65CSNK1A10.37020789
66TESK10.36161286
67IKBKB0.35455998
68NEK60.35241796
69PIM10.35212326
70NME10.34005672
71PHKG10.33111930
72PHKG20.33111930
73ROCK10.32416132
74TLK10.32189662
75MAP3K80.29974254
76FGFR10.29590958
77PRKCE0.29137445
78STK240.28962004
79LCK0.28483629
80ABL10.26380236
81MAPKAPK50.26204765
82ROCK20.25582011
83BLK0.25487777
84KIT0.25104081
85CAMK2D0.24789755
86FES0.24657247
87RPS6KB10.24194333
88BTK0.19504250
89TAOK10.19387920
90CHUK0.19154247
91CAMK2A0.15159374
92LIMK10.14739329
93TRPM70.14173641
94JAK10.14060213
95MYLK0.13780311
96NTRK30.13680484
97ERBB20.13680039
98MAP3K120.12920396
99CDK120.12136279
100PRKACA0.11741627

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.37648085
2Protein export_Homo sapiens_hsa030603.82731523
3Proteasome_Homo sapiens_hsa030503.24544598
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34157950
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28781562
6Parkinsons disease_Homo sapiens_hsa050122.21547993
7Peroxisome_Homo sapiens_hsa041462.09475187
8RNA polymerase_Homo sapiens_hsa030202.07849666
9Phototransduction_Homo sapiens_hsa047442.01235561
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93955509
11Oxidative phosphorylation_Homo sapiens_hsa001901.91715489
12Butanoate metabolism_Homo sapiens_hsa006501.79225459
13One carbon pool by folate_Homo sapiens_hsa006701.64842307
14Gastric acid secretion_Homo sapiens_hsa049711.64157401
15Non-homologous end-joining_Homo sapiens_hsa034501.62811712
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.60195828
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58578426
18Sulfur metabolism_Homo sapiens_hsa009201.52557658
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47289631
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46593027
21Basal transcription factors_Homo sapiens_hsa030221.43579781
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41729519
23Nitrogen metabolism_Homo sapiens_hsa009101.40825681
24Linoleic acid metabolism_Homo sapiens_hsa005911.37034598
25Primary immunodeficiency_Homo sapiens_hsa053401.27546960
26Glycerolipid metabolism_Homo sapiens_hsa005611.26603886
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20437717
28Folate biosynthesis_Homo sapiens_hsa007901.17626202
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17160504
30Selenocompound metabolism_Homo sapiens_hsa004501.10249104
31Alzheimers disease_Homo sapiens_hsa050101.08596749
32Regulation of autophagy_Homo sapiens_hsa041401.08208009
33Measles_Homo sapiens_hsa051621.06764181
34Ether lipid metabolism_Homo sapiens_hsa005651.06687810
35Fatty acid biosynthesis_Homo sapiens_hsa000611.05491254
36Insulin secretion_Homo sapiens_hsa049111.02976595
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01663729
38Fatty acid degradation_Homo sapiens_hsa000710.97638988
39beta-Alanine metabolism_Homo sapiens_hsa004100.96208107
40Steroid biosynthesis_Homo sapiens_hsa001000.94287814
41Hematopoietic cell lineage_Homo sapiens_hsa046400.89421662
42Huntingtons disease_Homo sapiens_hsa050160.87732052
43Type I diabetes mellitus_Homo sapiens_hsa049400.84583491
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84308484
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81408173
46RNA degradation_Homo sapiens_hsa030180.80036124
47Tryptophan metabolism_Homo sapiens_hsa003800.79955411
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79288942
49Vibrio cholerae infection_Homo sapiens_hsa051100.79113144
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74810847
51Purine metabolism_Homo sapiens_hsa002300.74564631
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74146309
53Salivary secretion_Homo sapiens_hsa049700.71983347
54Arginine and proline metabolism_Homo sapiens_hsa003300.71948682
55ABC transporters_Homo sapiens_hsa020100.71214576
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70277597
57Chemical carcinogenesis_Homo sapiens_hsa052040.69721839
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68049485
59Olfactory transduction_Homo sapiens_hsa047400.67622304
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67567854
61Thyroid hormone synthesis_Homo sapiens_hsa049180.66662538
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66514430
63Ovarian steroidogenesis_Homo sapiens_hsa049130.66236982
64Systemic lupus erythematosus_Homo sapiens_hsa053220.66107172
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63340552
66Renin secretion_Homo sapiens_hsa049240.63241603
67Pancreatic secretion_Homo sapiens_hsa049720.62452245
68Arachidonic acid metabolism_Homo sapiens_hsa005900.62359693
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.61395006
70Propanoate metabolism_Homo sapiens_hsa006400.61248077
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60100423
72Autoimmune thyroid disease_Homo sapiens_hsa053200.59011991
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57907114
74Histidine metabolism_Homo sapiens_hsa003400.57345529
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56891873
76Allograft rejection_Homo sapiens_hsa053300.55455584
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.55326431
78Shigellosis_Homo sapiens_hsa051310.55150071
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.54743926
80Fanconi anemia pathway_Homo sapiens_hsa034600.54408500
81Retinol metabolism_Homo sapiens_hsa008300.53709748
82Metabolic pathways_Homo sapiens_hsa011000.49578007
83Morphine addiction_Homo sapiens_hsa050320.48300341
84Graft-versus-host disease_Homo sapiens_hsa053320.47290973
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46485574
86Pyrimidine metabolism_Homo sapiens_hsa002400.46321580
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.45986352
88Amphetamine addiction_Homo sapiens_hsa050310.43882493
89Cardiac muscle contraction_Homo sapiens_hsa042600.43772083
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42001514
91Fatty acid metabolism_Homo sapiens_hsa012120.41847623
92T cell receptor signaling pathway_Homo sapiens_hsa046600.41306468
93Vitamin digestion and absorption_Homo sapiens_hsa049770.38859804
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36474973
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36294718
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35519767
97Mineral absorption_Homo sapiens_hsa049780.34813038
98Type II diabetes mellitus_Homo sapiens_hsa049300.34428061
99Bile secretion_Homo sapiens_hsa049760.32535616
100GABAergic synapse_Homo sapiens_hsa047270.31941370

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