ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.31783243
2	cytidine deamination (GO:0009972)	6.10705079
3	cytidine metabolic process (GO:0046087)	6.10705079
4	cytidine catabolic process (GO:0006216)	6.10705079
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.87847099
6	meiotic chromosome segregation (GO:0045132)	5.25321262
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.24293437
8	positive regulation of defense response to virus by host (GO:0002230)	4.81072863
9	regulation of chronic inflammatory response (GO:0002676)	4.44703808
10	rRNA catabolic process (GO:0016075)	4.13566077
11	mismatch repair (GO:0006298)	4.01175567
12	negative regulation of execution phase of apoptosis (GO:1900118)	3.95633576
13	protein K11-linked deubiquitination (GO:0035871)	3.91001717
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.82360131
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.82360131
16	snRNA processing (GO:0016180)	3.73074383
17	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.63630334
18	mitochondrion degradation (GO:0000422)	3.53196469
19	cellular ketone body metabolic process (GO:0046950)	3.48445951
20	response to pheromone (GO:0019236)	3.43777772
21	regulation of MHC class II biosynthetic process (GO:0045346)	3.37296291
22	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.28772861
23	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.21900601
24	ketone body metabolic process (GO:1902224)	3.21377188
25	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.20514492
26	actin nucleation (GO:0045010)	3.17333289
27	snRNA metabolic process (GO:0016073)	3.16893992
28	positive regulation of histone H3-K4 methylation (GO:0051571)	3.15809701
29	proteasome assembly (GO:0043248)	3.13601073
30	platelet dense granule organization (GO:0060155)	3.11086165
31	positive regulation of prostaglandin secretion (GO:0032308)	3.09987075
32	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.08045535
33	positive regulation of T-helper 1 type immune response (GO:0002827)	3.07392471
34	regulation of B cell receptor signaling pathway (GO:0050855)	3.06253267
35	response to interferon-beta (GO:0035456)	3.05366686
36	L-fucose catabolic process (GO:0042355)	3.03128766
37	fucose catabolic process (GO:0019317)	3.03128766
38	L-fucose metabolic process (GO:0042354)	3.03128766
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.02974887
40	regulation of memory T cell differentiation (GO:0043380)	3.02869493
41	auditory receptor cell stereocilium organization (GO:0060088)	3.02866591
42	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.01927745
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.99452439
44	negative regulation of type I interferon production (GO:0032480)	2.96404617
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.96122622
46	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.95704247
47	T cell migration (GO:0072678)	2.94944318
48	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.93515674
49	adenosine metabolic process (GO:0046085)	2.92324476
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.90882449
51	positive regulation of humoral immune response (GO:0002922)	2.90225300
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.84461018
53	regulation of defense response to virus by host (GO:0050691)	2.83065258
54	respiratory chain complex IV assembly (GO:0008535)	2.82435133
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.81176029
56	ATP synthesis coupled proton transport (GO:0015986)	2.81176029
57	nucleotide transmembrane transport (GO:1901679)	2.78403679
58	reciprocal DNA recombination (GO:0035825)	2.78042537
59	reciprocal meiotic recombination (GO:0007131)	2.78042537
60	pyrimidine nucleoside catabolic process (GO:0046135)	2.76641713
61	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.76449115
62	tryptophan metabolic process (GO:0006568)	2.76237467
63	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.76138361
64	kynurenine metabolic process (GO:0070189)	2.75749501
65	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.75265652
66	peptidyl-threonine dephosphorylation (GO:0035970)	2.74966052
67	protein complex biogenesis (GO:0070271)	2.72184225
68	negative regulation of viral genome replication (GO:0045071)	2.72035497
69	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.71842332
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71215440
71	C-terminal protein lipidation (GO:0006501)	2.70088982
72	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.67715935
73	piRNA metabolic process (GO:0034587)	2.67550040
74	tryptophan catabolic process (GO:0006569)	2.66723773
75	indole-containing compound catabolic process (GO:0042436)	2.66723773
76	indolalkylamine catabolic process (GO:0046218)	2.66723773
77	rRNA modification (GO:0000154)	2.66584953
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65913911
79	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.65054349
80	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.63957275
81	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.63694017
82	positive regulation of cell killing (GO:0031343)	2.62970440
83	DNA demethylation (GO:0080111)	2.62892460
84	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.60031285
85	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.60031285
86	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.59810933
87	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.59563129
88	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.59563129
89	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.59563129
90	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.59030854
91	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.58257984
92	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.58070781
93	regulation of regulatory T cell differentiation (GO:0045589)	2.56594514
94	cellular response to exogenous dsRNA (GO:0071360)	2.55315063
95	mitochondrial respiratory chain complex assembly (GO:0033108)	2.54507414
96	cellular response to interleukin-15 (GO:0071350)	2.54280127
97	rRNA methylation (GO:0031167)	2.53960167
98	cellular response to zinc ion (GO:0071294)	2.51370221
99	regulation of T cell mediated cytotoxicity (GO:0001914)	2.49638115
100	positive regulation of monocyte chemotaxis (GO:0090026)	2.49510207

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.33792786
2	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.30799106
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.23459130
4	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.23214002
5	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.12219195
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.91799999
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79250631
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63805187
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61116065
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60775860
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39024078
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.35354776
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.33614169
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.25883248
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.24804465
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21669439
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19726035
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.17464977
19	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.99077298
20	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.95581465
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94351742
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.80778942
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77867177
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.75945864
25	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.75025932
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.75025932
27	MYB_26560356_Chip-Seq_TH2_Human	1.73796955
28	GATA3_26560356_Chip-Seq_TH2_Human	1.70642230
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65539533
30	AR_20517297_ChIP-Seq_VCAP_Human	1.63428637
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57430533
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56615705
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55038403
34	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.52805071
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52475421
36	EWS_26573619_Chip-Seq_HEK293_Human	1.50759514
37	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.47625052
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.47396481
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47361319
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.46155749
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45107255
42	GATA3_27048872_Chip-Seq_THYMUS_Human	1.43301452
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43213819
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40817541
45	VDR_22108803_ChIP-Seq_LS180_Human	1.40449226
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.39737219
47	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.37798185
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.34001938
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33588622
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33107146
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.33107146
52	HOXB7_26014856_ChIP-Seq_BT474_Human	1.31980771
53	HTT_18923047_ChIP-ChIP_STHdh_Human	1.31951377
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30756038
55	NCOR_22424771_ChIP-Seq_293T_Human	1.30365096
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.29571359
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29377958
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29258294
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27458208
60	CIITA_25753668_ChIP-Seq_RAJI_Human	1.26797555
61	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.24822911
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24281806
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22890967
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22509655
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.21700837
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21337295
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.20754542
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20580478
69	GBX2_23144817_ChIP-Seq_PC3_Human	1.19633989
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19054177
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17060077
72	GATA3_26560356_Chip-Seq_TH1_Human	1.16315622
73	P300_19829295_ChIP-Seq_ESCs_Human	1.15925412
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13155262
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12951242
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11276205
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10965141
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10965141
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09796964
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09796916
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09735306
82	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09195389
83	FUS_26573619_Chip-Seq_HEK293_Human	1.08833288
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07205041
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06546293
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05438613
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02123470
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01124160
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00753840
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.99860468
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98848117
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98586058
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97490019
94	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95795890
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.95680585
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94538726
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.93438492
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.93437430
99	SMRT_27268052_Chip-Seq_Bcells_Human	0.92976999
100	P300_27268052_Chip-Seq_Bcells_Human	0.92317759

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.66311262
2	MP0009785_altered_susceptibility_to	3.13942237
3	MP0005646_abnormal_pituitary_gland	2.84316355
4	MP0001835_abnormal_antigen_presentation	2.83568590
5	MP0000685_abnormal_immune_system	2.79874673
6	MP0002138_abnormal_hepatobiliary_system	2.69621340
7	MP0008877_abnormal_DNA_methylation	2.63758883
8	MP0005645_abnormal_hypothalamus_physiol	2.49040929
9	MP0009764_decreased_sensitivity_to	2.44519677
10	MP0005310_abnormal_salivary_gland	2.29394139
11	MP0002148_abnormal_hypersensitivity_rea	2.27004922
12	MP0002876_abnormal_thyroid_physiology	2.21143433
13	MP0002166_altered_tumor_susceptibility	2.17478867
14	MP0001800_abnormal_humoral_immune	2.12218733
15	MP0003878_abnormal_ear_physiology	2.11403503
16	MP0005377_hearing/vestibular/ear_phenot	2.11403503
17	MP0005000_abnormal_immune_tolerance	2.09551945
18	MP0001790_abnormal_immune_system	1.96758667
19	MP0005387_immune_system_phenotype	1.96758667
20	MP0002693_abnormal_pancreas_physiology	1.96113586
21	MP0004147_increased_porphyrin_level	1.94387651
22	MP0002837_dystrophic_cardiac_calcinosis	1.93780250
23	MP0002723_abnormal_immune_serum	1.87826447
24	MP0004885_abnormal_endolymph	1.84972856
25	MP0002006_tumorigenesis	1.82529491
26	MP0003787_abnormal_imprinting	1.80096293
27	MP0006072_abnormal_retinal_apoptosis	1.76593036
28	MP0000372_irregular_coat_pigmentation	1.75992979
29	MP0008875_abnormal_xenobiotic_pharmacok	1.73520958
30	MP0003806_abnormal_nucleotide_metabolis	1.68961916
31	MP0003646_muscle_fatigue	1.62103025
32	MP0002420_abnormal_adaptive_immunity	1.60796846
33	MP0005025_abnormal_response_to	1.60318548
34	MP0001819_abnormal_immune_cell	1.56300674
35	MP0002452_abnormal_antigen_presenting	1.55163929
36	MP0005075_abnormal_melanosome_morpholog	1.54830575
37	MP0006082_CNS_inflammation	1.52141125
38	MP0005551_abnormal_eye_electrophysiolog	1.50629600
39	MP0009333_abnormal_splenocyte_physiolog	1.49824393
40	MP0001845_abnormal_inflammatory_respons	1.48334586
41	MP0003011_delayed_dark_adaptation	1.44042727
42	MP0003045_fibrosis	1.42583316
43	MP0004484_altered_response_of	1.42183811
44	MP0008469_abnormal_protein_level	1.41536392
45	MP0005165_increased_susceptibility_to	1.40826718
46	MP0001501_abnormal_sleep_pattern	1.39004154
47	MP0004215_abnormal_myocardial_fiber	1.38700216
48	MP0003866_abnormal_defecation	1.38649647
49	MP0003195_calcinosis	1.38317283
50	MP0005332_abnormal_amino_acid	1.35643381
51	MP0008872_abnormal_physiological_respon	1.33567569
52	MP0009643_abnormal_urine_homeostasis	1.32354666
53	MP0005379_endocrine/exocrine_gland_phen	1.31931655
54	MP0001764_abnormal_homeostasis	1.29339492
55	MP0003763_abnormal_thymus_physiology	1.29206911
56	MP0010155_abnormal_intestine_physiology	1.24854271
57	MP0009745_abnormal_behavioral_response	1.23362787
58	MP0002102_abnormal_ear_morphology	1.23111971
59	MP0006036_abnormal_mitochondrial_physio	1.22183416
60	MP0000716_abnormal_immune_system	1.18694244
61	MP0005253_abnormal_eye_physiology	1.16949196
62	MP0002163_abnormal_gland_morphology	1.14890593
63	MP0004381_abnormal_hair_follicle	1.14158328
64	MP0005410_abnormal_fertilization	1.14069228
65	MP0003436_decreased_susceptibility_to	1.11054897
66	MP0002405_respiratory_system_inflammati	1.09650991
67	MP0005167_abnormal_blood-brain_barrier	1.08373726
68	MP0009780_abnormal_chondrocyte_physiolo	1.05973462
69	MP0005085_abnormal_gallbladder_physiolo	1.03426184
70	MP0004145_abnormal_muscle_electrophysio	1.02555012
71	MP0002398_abnormal_bone_marrow	1.01369352
72	MP0001968_abnormal_touch/_nociception	1.00320443
73	MP0002419_abnormal_innate_immunity	0.99484286
74	MP0002277_abnormal_respiratory_mucosa	0.97816630
75	MP0000689_abnormal_spleen_morphology	0.91766799
76	MP0002139_abnormal_hepatobiliary_system	0.91429754
77	MP0001905_abnormal_dopamine_level	0.88590496
78	MP0006054_spinal_hemorrhage	0.87647168
79	MP0008058_abnormal_DNA_repair	0.87154426
80	MP0005166_decreased_susceptibility_to	0.86728690
81	MP0002429_abnormal_blood_cell	0.86190711
82	MP0002933_joint_inflammation	0.84157112
83	MP0001944_abnormal_pancreas_morphology	0.82429782
84	MP0004043_abnormal_pH_regulation	0.82425061
85	MP0005408_hypopigmentation	0.81962632
86	MP0005636_abnormal_mineral_homeostasis	0.81960775
87	MP0001873_stomach_inflammation	0.81681068
88	MP0002722_abnormal_immune_system	0.77690255
89	MP0000230_abnormal_systemic_arterial	0.77648194
90	MP0010386_abnormal_urinary_bladder	0.77609318
91	MP0005220_abnormal_exocrine_pancreas	0.77251819
92	MP0005448_abnormal_energy_balance	0.74821066
93	MP0002733_abnormal_thermal_nociception	0.72186473
94	MP0001970_abnormal_pain_threshold	0.71965951
95	MP0005084_abnormal_gallbladder_morpholo	0.71544066
96	MP0003718_maternal_effect	0.70322865
97	MP0002136_abnormal_kidney_physiology	0.69436004
98	MP0003879_abnormal_hair_cell	0.68757033
99	MP0005365_abnormal_bile_salt	0.68749554
100	MP0002078_abnormal_glucose_homeostasis	0.68602657

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.17565487
2	Stomatitis (HP:0010280)	3.87292905
3	IgG deficiency (HP:0004315)	3.86731733
4	Progressive macrocephaly (HP:0004481)	3.67043249
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57578558
6	Mitochondrial inheritance (HP:0001427)	3.54702270
7	Congenital stationary night blindness (HP:0007642)	3.53918931
8	3-Methylglutaconic aciduria (HP:0003535)	3.46434907
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.44751444
10	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.44337259
11	Acute encephalopathy (HP:0006846)	3.39174904
12	Pigmentary retinal degeneration (HP:0001146)	3.25335561
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.24380553
14	Lipid accumulation in hepatocytes (HP:0006561)	3.24276978
15	Chronic bronchitis (HP:0004469)	3.19176601
16	Pancreatic cysts (HP:0001737)	3.13268652
17	Attenuation of retinal blood vessels (HP:0007843)	3.09656606
18	Increased hepatocellular lipid droplets (HP:0006565)	3.09631543
19	Severe combined immunodeficiency (HP:0004430)	3.07930729
20	Bronchitis (HP:0012387)	3.04753123
21	Increased CSF lactate (HP:0002490)	2.96789346
22	Recurrent bronchitis (HP:0002837)	2.94836982
23	T lymphocytopenia (HP:0005403)	2.93536628
24	Type II lissencephaly (HP:0007260)	2.93369942
25	Decreased central vision (HP:0007663)	2.90870495
26	Abnormality of T cell number (HP:0011839)	2.89316105
27	Renal Fanconi syndrome (HP:0001994)	2.83729780
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.82778295
29	Thyroiditis (HP:0100646)	2.68973308
30	Abnormality of T cells (HP:0002843)	2.66807221
31	Hepatocellular necrosis (HP:0001404)	2.66095606
32	Mesangial abnormality (HP:0001966)	2.65914678
33	Abnormal albumin level (HP:0012116)	2.65378228
34	Hypoalbuminemia (HP:0003073)	2.65378228
35	Ketosis (HP:0001946)	2.63840682
36	Abnormality of the renal cortex (HP:0011035)	2.61153918
37	Lymphopenia (HP:0001888)	2.60984912
38	Renal cortical cysts (HP:0000803)	2.58955377
39	Ketoacidosis (HP:0001993)	2.58851809
40	Recurrent cutaneous fungal infections (HP:0011370)	2.58413545
41	Chronic mucocutaneous candidiasis (HP:0002728)	2.58413545
42	Cerebral edema (HP:0002181)	2.57840204
43	Molar tooth sign on MRI (HP:0002419)	2.55145881
44	Abnormality of midbrain morphology (HP:0002418)	2.55145881
45	Abnormality of B cell number (HP:0010975)	2.55115016
46	Recurrent otitis media (HP:0000403)	2.53664402
47	Hepatic necrosis (HP:0002605)	2.46785156
48	Hypoproteinemia (HP:0003075)	2.43436562
49	Abnormality of T cell physiology (HP:0011840)	2.43378492
50	Combined immunodeficiency (HP:0005387)	2.41430140
51	Optic disc pallor (HP:0000543)	2.41149195
52	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.41036779
53	Abolished electroretinogram (ERG) (HP:0000550)	2.40358634
54	Gastrointestinal stroma tumor (HP:0100723)	2.39238752
55	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.33761727
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.33579436
57	B lymphocytopenia (HP:0010976)	2.30909468
58	Retinal dysplasia (HP:0007973)	2.30904009
59	Pancreatic fibrosis (HP:0100732)	2.29881584
60	Vasculitis (HP:0002633)	2.29293379
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26115725
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26115725
63	Abnormality of eosinophils (HP:0001879)	2.25831130
64	Aplastic anemia (HP:0001915)	2.22088286
65	IgM deficiency (HP:0002850)	2.20641880
66	Lactic acidosis (HP:0003128)	2.19070611
67	Generalized aminoaciduria (HP:0002909)	2.18667575
68	Exertional dyspnea (HP:0002875)	2.17976687
69	Hemoptysis (HP:0002105)	2.14363743
70	Abnormality of alanine metabolism (HP:0010916)	2.13515408
71	Hyperalaninemia (HP:0003348)	2.13515408
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13515408
73	Optic neuritis (HP:0100653)	2.13003095
74	Retrobulbar optic neuritis (HP:0100654)	2.13003095
75	Bony spicule pigmentary retinopathy (HP:0007737)	2.09852505
76	Encephalitis (HP:0002383)	2.08314509
77	Increased IgM level (HP:0003496)	2.08145115
78	IgA deficiency (HP:0002720)	2.07997690
79	Autoimmune hemolytic anemia (HP:0001890)	2.07485710
80	True hermaphroditism (HP:0010459)	2.06350983
81	Gastrointestinal infarctions (HP:0005244)	2.06135681
82	Increased intramyocellular lipid droplets (HP:0012240)	2.04549893
83	Chronic diarrhea (HP:0002028)	2.04423362
84	Increased serum lactate (HP:0002151)	2.02084240
85	Glycosuria (HP:0003076)	2.01051509
86	Abnormality of urine glucose concentration (HP:0011016)	2.01051509
87	Bronchiectasis (HP:0002110)	1.97405215
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97225080
89	Eosinophilia (HP:0001880)	1.95467847
90	Polydipsia (HP:0001959)	1.95449935
91	Abnormal drinking behavior (HP:0030082)	1.95449935
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94521874
93	Leukodystrophy (HP:0002415)	1.92281140
94	Recurrent fungal infections (HP:0002841)	1.91433150
95	Increased muscle lipid content (HP:0009058)	1.90557881
96	Rhinitis (HP:0012384)	1.86856243
97	Recurrent sinusitis (HP:0011108)	1.86232562
98	Neutropenia (HP:0001875)	1.86141308
99	Decreased circulating renin level (HP:0003351)	1.83551519
100	Pulmonary infiltrates (HP:0002113)	1.77894861

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	5.59591305
2	FRK	4.42485762
3	KDR	3.29714425
4	MAPKAPK3	2.95958278
5	MAP3K12	2.48905111
6	CDK19	2.39132671
7	MAP4K2	2.38182480
8	GRK1	2.29491902
9	MST4	2.25286102
10	MAP3K9	2.13815861
11	TXK	2.13280415
12	TESK2	1.96417165
13	ZAK	1.91352667
14	TIE1	1.86952932
15	CAMKK2	1.84112405
16	BMPR1B	1.82602905
17	TAOK3	1.78556382
18	ADRBK2	1.76513815
19	NUAK1	1.53577216
20	TLK1	1.51224354
21	EIF2AK3	1.50190375
22	RIPK4	1.47629414
23	VRK1	1.47555947
24	TEC	1.46740925
25	VRK2	1.40067292
26	BCKDK	1.39166381
27	EIF2AK1	1.38915068
28	TRIM28	1.37661184
29	SRPK1	1.31656375
30	TNK2	1.26110689
31	PINK1	1.24072955
32	MAP4K1	1.20042001
33	ITK	1.19627723
34	MAP2K6	1.19511752
35	MARK3	1.19002185
36	NME1	1.16514430
37	KIT	1.12382980
38	PASK	1.10137731
39	WNK4	1.06980143
40	PDK1	1.05396209
41	WNK3	1.05378251
42	SYK	0.97441462
43	PRKCQ	0.97178397
44	IKBKB	0.89451086
45	DAPK1	0.86290848
46	LYN	0.85885480
47	RPS6KA5	0.78841158
48	MAPKAPK5	0.78693024
49	DYRK2	0.77327685
50	OXSR1	0.77036565
51	FES	0.74693877
52	PRKCE	0.73813457
53	EPHA3	0.69873342
54	RPS6KA4	0.65944517
55	PDPK1	0.64998152
56	BUB1	0.64190679
57	PRKCI	0.63272438
58	TGFBR1	0.61900295
59	PRKCH	0.60418469
60	NLK	0.58640431
61	LIMK1	0.57319450
62	CSNK1G3	0.55967386
63	ADRBK1	0.55011358
64	CDK8	0.53334385
65	EIF2AK2	0.52893334
66	CAMKK1	0.51890924
67	CDK9	0.49363613
68	DAPK2	0.48474107
69	EPHA4	0.48015518
70	PKN1	0.47717712
71	STK38L	0.47585393
72	PHKG2	0.47475724
73	PHKG1	0.47475724
74	STK16	0.47233151
75	TESK1	0.46015288
76	LCK	0.45677442
77	INSRR	0.44613926
78	PRKCG	0.43646966
79	GRK5	0.42982502
80	MUSK	0.42451705
81	HIPK2	0.41311640
82	CSNK1G1	0.40748295
83	SIK3	0.39040823
84	ROCK1	0.36852185
85	CSNK1G2	0.36459038
86	FGFR4	0.36103181
87	BMPR2	0.36010986
88	CSNK1A1	0.35084110
89	STK3	0.34940943
90	PAK3	0.34293504
91	GRK6	0.33215921
92	ALK	0.33064308
93	MAPKAPK2	0.32927245
94	MAPK13	0.32558716
95	PTK2B	0.32469723
96	CSNK1A1L	0.31584811
97	PRKCA	0.30426568
98	IKBKE	0.30076930
99	FGFR3	0.29945834
100	CAMK2D	0.28853430

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.09587158
2	Proteasome_Homo sapiens_hsa03050	3.95417429
3	Type I diabetes mellitus_Homo sapiens_hsa04940	2.76476825
4	Asthma_Homo sapiens_hsa05310	2.55255541
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50705650
6	Allograft rejection_Homo sapiens_hsa05330	2.45910425
7	Protein export_Homo sapiens_hsa03060	2.38826760
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.34485040
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.30421945
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29951385
11	Regulation of autophagy_Homo sapiens_hsa04140	2.26856547
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.15804923
13	Sulfur metabolism_Homo sapiens_hsa00920	2.15351242
14	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.14397229
15	Propanoate metabolism_Homo sapiens_hsa00640	1.97668074
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.96910016
17	Caffeine metabolism_Homo sapiens_hsa00232	1.96145140
18	Parkinsons disease_Homo sapiens_hsa05012	1.89019971
19	Phototransduction_Homo sapiens_hsa04744	1.78846818
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71479768
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67744450
22	RNA polymerase_Homo sapiens_hsa03020	1.63212025
23	Butanoate metabolism_Homo sapiens_hsa00650	1.50333109
24	Mismatch repair_Homo sapiens_hsa03430	1.47210668
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.42776651
26	One carbon pool by folate_Homo sapiens_hsa00670	1.38823695
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37578688
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.30286654
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.30094797
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.30066501
31	Homologous recombination_Homo sapiens_hsa03440	1.25931321
32	Alzheimers disease_Homo sapiens_hsa05010	1.19447988
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13342242
34	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.11163550
35	Huntingtons disease_Homo sapiens_hsa05016	1.08497639
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08191836
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.06196358
38	RNA degradation_Homo sapiens_hsa03018	1.03355653
39	Basal transcription factors_Homo sapiens_hsa03022	1.03319884
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01130157
41	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.99782168
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.97934988
43	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97756413
44	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.97487402
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96291396
46	Measles_Homo sapiens_hsa05162	0.90226287
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88248211
48	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.87275019
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.85791134
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85413660
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83905281
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83233835
53	Peroxisome_Homo sapiens_hsa04146	0.79290625
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78327493
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77275948
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.76710787
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76651244
58	Purine metabolism_Homo sapiens_hsa00230	0.75907963
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.75712404
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75574160
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72943887
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71041310
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70772282
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70290825
65	Fatty acid degradation_Homo sapiens_hsa00071	0.69408498
66	Salmonella infection_Homo sapiens_hsa05132	0.68692684
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68437025
68	Herpes simplex infection_Homo sapiens_hsa05168	0.64705489
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.63855578
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62244126
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60078722
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56495625
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.53138451
74	Morphine addiction_Homo sapiens_hsa05032	0.52903831
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52818686
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52462402
77	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.50560805
78	Olfactory transduction_Homo sapiens_hsa04740	0.50452987
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50209567
80	Metabolic pathways_Homo sapiens_hsa01100	0.45977965
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44015726
82	Mineral absorption_Homo sapiens_hsa04978	0.41051030
83	Viral myocarditis_Homo sapiens_hsa05416	0.40775932
84	DNA replication_Homo sapiens_hsa03030	0.39748418
85	Ribosome_Homo sapiens_hsa03010	0.38358778
86	Pentose phosphate pathway_Homo sapiens_hsa00030	0.36548412
87	Taste transduction_Homo sapiens_hsa04742	0.33479935
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31507689
89	Retinol metabolism_Homo sapiens_hsa00830	0.30888045
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.29508629
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28780981
92	Insulin secretion_Homo sapiens_hsa04911	0.24613616
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24199555
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24153670
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23696172
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.23012490
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.21791065
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18663362
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.16899480
100	Serotonergic synapse_Homo sapiens_hsa04726	0.16055615

ZBTB8OSP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »