ZC2HC1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.34343286
2synaptic vesicle exocytosis (GO:0016079)5.07260528
3vocalization behavior (GO:0071625)5.06598696
4nucleobase catabolic process (GO:0046113)4.76645925
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.75972383
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.73009391
7glutamate secretion (GO:0014047)4.70496542
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68768068
9protein localization to synapse (GO:0035418)4.62109859
10regulation of synaptic vesicle exocytosis (GO:2000300)4.53296000
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29007416
12presynaptic membrane assembly (GO:0097105)4.25799309
13postsynaptic membrane organization (GO:0001941)4.19338822
14regulation of glutamate receptor signaling pathway (GO:1900449)4.16728544
15neuron recognition (GO:0008038)4.15708785
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.09941579
17neurotransmitter-gated ion channel clustering (GO:0072578)4.02387118
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98624278
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96145484
20regulation of synaptic vesicle transport (GO:1902803)3.93853688
21presynaptic membrane organization (GO:0097090)3.90876638
22behavioral response to nicotine (GO:0035095)3.81284889
23synaptic vesicle maturation (GO:0016188)3.80275114
24neurotransmitter secretion (GO:0007269)3.76454692
25axonal fasciculation (GO:0007413)3.73936192
26neuronal action potential propagation (GO:0019227)3.73860476
27nonmotile primary cilium assembly (GO:0035058)3.69441032
28limb bud formation (GO:0060174)3.68180396
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.65544556
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65183347
31negative regulation of dendrite morphogenesis (GO:0050774)3.63706504
32neuron-neuron synaptic transmission (GO:0007270)3.61449638
33retinal ganglion cell axon guidance (GO:0031290)3.55252779
34cell migration in hindbrain (GO:0021535)3.54247608
35glutamate receptor signaling pathway (GO:0007215)3.53725821
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53647185
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51094647
38sequestering of actin monomers (GO:0042989)3.51052271
39positive regulation of synapse assembly (GO:0051965)3.49052823
40synaptic transmission, glutamatergic (GO:0035249)3.47139479
41protein localization to cilium (GO:0061512)3.45013938
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.44125806
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39838952
44gamma-aminobutyric acid transport (GO:0015812)3.39452084
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38916506
46central nervous system projection neuron axonogenesis (GO:0021952)3.38889229
47epithelial cilium movement (GO:0003351)3.38731623
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38078962
49proline transport (GO:0015824)3.37634700
50regulation of synapse structural plasticity (GO:0051823)3.36396986
51regulation of cilium movement (GO:0003352)3.33390853
52positive regulation of synapse maturation (GO:0090129)3.29951806
53response to histamine (GO:0034776)3.23520583
54negative regulation of dendrite development (GO:2000171)3.22820331
55layer formation in cerebral cortex (GO:0021819)3.22314107
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20835901
57synapse assembly (GO:0007416)3.18688648
58establishment of mitochondrion localization (GO:0051654)3.18590250
59regulation of postsynaptic membrane potential (GO:0060078)3.18093698
60regulation of glutamate secretion (GO:0014048)3.17922897
61negative regulation of microtubule polymerization (GO:0031115)3.17150143
62regulation of respiratory system process (GO:0044065)3.16659844
63exploration behavior (GO:0035640)3.15045143
64locomotory exploration behavior (GO:0035641)3.14824671
65regulation of neurotransmitter secretion (GO:0046928)3.14454865
66cerebral cortex radially oriented cell migration (GO:0021799)3.14241647
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.09958483
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09315571
69regulation of neuronal synaptic plasticity (GO:0048168)3.08954238
70pyrimidine nucleobase catabolic process (GO:0006208)3.08135201
71long-term synaptic potentiation (GO:0060291)3.07242444
72intraciliary transport (GO:0042073)3.06282787
73cerebellar granule cell differentiation (GO:0021707)3.05361254
74neurotransmitter transport (GO:0006836)3.03659501
75cilium movement (GO:0003341)3.03219630
76negative regulation of axon guidance (GO:1902668)3.02848999
77regulation of synapse assembly (GO:0051963)3.01798035
78short-term memory (GO:0007614)3.01267579
79regulation of vesicle fusion (GO:0031338)3.00210092
80axon extension (GO:0048675)2.99484213
81ATP hydrolysis coupled proton transport (GO:0015991)2.98447884
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.98447884
83transferrin transport (GO:0033572)2.97998685
84regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97986666
85neuronal action potential (GO:0019228)2.97719877
86positive regulation of neurotransmitter secretion (GO:0001956)2.97592109
87substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96104934
88substrate-independent telencephalic tangential migration (GO:0021826)2.96104934
89synaptic vesicle endocytosis (GO:0048488)2.95844390
90startle response (GO:0001964)2.95065079
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92793151
92dendrite morphogenesis (GO:0048813)2.92721906
93innervation (GO:0060384)2.92601385
94positive regulation of neurotransmitter transport (GO:0051590)2.91321760
95mechanosensory behavior (GO:0007638)2.90028290
96transmission of nerve impulse (GO:0019226)2.89890176
97regulation of synapse maturation (GO:0090128)2.88947986
98neural tube formation (GO:0001841)2.88701962
99regulation of neurotransmitter transport (GO:0051588)2.88013542
100regulation of respiratory gaseous exchange (GO:0043576)2.87577828
101cilium morphogenesis (GO:0060271)2.86503406
102positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85375132
103dendrite development (GO:0016358)2.85275843
104central nervous system neuron axonogenesis (GO:0021955)2.85236939
105synaptic vesicle transport (GO:0048489)2.84663646
106establishment of synaptic vesicle localization (GO:0097480)2.84663646
107auditory behavior (GO:0031223)2.83090508
108ferric iron transport (GO:0015682)2.82025221
109trivalent inorganic cation transport (GO:0072512)2.82025221
110cerebellar Purkinje cell differentiation (GO:0021702)2.81285920
111dendritic spine morphogenesis (GO:0060997)2.81147382
112membrane depolarization during action potential (GO:0086010)2.79768489
113membrane depolarization (GO:0051899)2.79727717
114negative regulation of axon extension (GO:0030517)2.79141220
115positive regulation of membrane potential (GO:0045838)2.79090662
116regulation of neurotransmitter levels (GO:0001505)2.76880733
117calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76558244
118behavioral response to ethanol (GO:0048149)2.76549407
119regulation of protein kinase A signaling (GO:0010738)2.76164144
120regulation of synaptic plasticity (GO:0048167)2.75758120
121behavioral response to cocaine (GO:0048148)2.75585588
122synaptic transmission (GO:0007268)2.74005951
123establishment of vesicle localization (GO:0051650)2.73857970
124female mating behavior (GO:0060180)2.73598221
125regulation of synapse organization (GO:0050807)2.73062902
126response to auditory stimulus (GO:0010996)2.72329444
127glycosphingolipid biosynthetic process (GO:0006688)2.72158017
128regulation of synaptic transmission, GABAergic (GO:0032228)2.71766892
129spinal cord development (GO:0021510)2.71369635
130cilium organization (GO:0044782)2.70640167
131cilium assembly (GO:0042384)2.69976071
132sympathetic nervous system development (GO:0048485)2.69307753
133regulation of axon guidance (GO:1902667)2.67184393
134forebrain neuron differentiation (GO:0021879)2.66963224
135adult walking behavior (GO:0007628)2.65576623
136positive regulation of mitochondrial fission (GO:0090141)2.64577091
137regulation of feeding behavior (GO:0060259)2.63741547
138regulation of microtubule-based movement (GO:0060632)2.60490413
139hindbrain development (GO:0030902)2.58458828
140regulation of collateral sprouting (GO:0048670)2.57561436
141synapse organization (GO:0050808)2.57348938
142axonemal dynein complex assembly (GO:0070286)2.56246528
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.55868254
144neuromuscular synaptic transmission (GO:0007274)2.54053821
145protein polyglutamylation (GO:0018095)2.53707044
146neurofilament cytoskeleton organization (GO:0060052)2.53120282
147mitochondrial respiratory chain complex I assembly (GO:0032981)2.52067474
148NADH dehydrogenase complex assembly (GO:0010257)2.52067474
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52067474
150spinal cord motor neuron differentiation (GO:0021522)2.49171796
151somite development (GO:0061053)2.48967782
152regulation of action potential (GO:0098900)2.48660698
153adult behavior (GO:0030534)2.47904355
154positive regulation of action potential (GO:0045760)2.47882840
155olfactory bulb development (GO:0021772)2.46803628
156cilium or flagellum-dependent cell motility (GO:0001539)2.45105732
157axoneme assembly (GO:0035082)2.44321064
158hippocampus development (GO:0021766)2.43977922
159behavioral fear response (GO:0001662)2.42559936
160behavioral defense response (GO:0002209)2.42559936
161mitochondrion transport along microtubule (GO:0047497)2.42374795
162establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.42374795
163establishment of melanosome localization (GO:0032401)2.42282771
164neuron fate determination (GO:0048664)2.42152870
165protein complex biogenesis (GO:0070271)2.41548412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23459890
2GBX2_23144817_ChIP-Seq_PC3_Human4.40484439
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96714678
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78833374
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75727426
6TAF15_26573619_Chip-Seq_HEK293_Human2.75539286
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.51518988
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50615223
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45213081
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45213081
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42150743
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40072708
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39343747
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32486536
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.29746202
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26304500
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25780577
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25659580
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25043531
20REST_21632747_ChIP-Seq_MESCs_Mouse2.23661053
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13261973
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10069410
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08395885
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08000461
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96124523
26P300_19829295_ChIP-Seq_ESCs_Human1.95136109
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93960466
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.92674313
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.89845466
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86768805
31SMAD4_21799915_ChIP-Seq_A2780_Human1.85531523
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83220741
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.81935867
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.77572511
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.74165697
36RNF2_27304074_Chip-Seq_NSC_Mouse1.71559790
37FUS_26573619_Chip-Seq_HEK293_Human1.68744488
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68701247
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67382269
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66341065
41AR_21572438_ChIP-Seq_LNCaP_Human1.65202715
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.64490212
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64091578
44IGF1R_20145208_ChIP-Seq_DFB_Human1.63653413
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61678686
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.60562925
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58546391
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.57312151
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54105135
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53094205
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.52463678
52DROSHA_22980978_ChIP-Seq_HELA_Human1.51764272
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50834739
54ZNF274_21170338_ChIP-Seq_K562_Hela1.50659600
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.48907490
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48497528
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47646103
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45661058
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43076172
60VDR_22108803_ChIP-Seq_LS180_Human1.41651633
61AR_25329375_ChIP-Seq_VCAP_Human1.41252492
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37743035
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36381428
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34799916
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33928034
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.33368677
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32689868
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32370848
69TP53_18474530_ChIP-ChIP_U2OS_Human1.31411255
70ER_23166858_ChIP-Seq_MCF-7_Human1.29442527
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28930848
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27640772
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.25883351
74JUN_21703547_ChIP-Seq_K562_Human1.25472743
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23918448
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22716794
77STAT3_23295773_ChIP-Seq_U87_Human1.22370453
78RUNX2_22187159_ChIP-Seq_PCA_Human1.21141846
79AHR_22903824_ChIP-Seq_MCF-7_Human1.20241216
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20109420
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17270583
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.13467011
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12834056
84TCF4_23295773_ChIP-Seq_U87_Human1.12409723
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.11295327
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10991730
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10411529
88P53_22387025_ChIP-Seq_ESCs_Mouse1.09780029
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09586704
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09051240
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08528102
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.08452564
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08274583
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.08271145
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08044682
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07166822
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06633955
98BCAT_22108803_ChIP-Seq_LS180_Human1.06478399
99TCF4_22108803_ChIP-Seq_LS180_Human1.06366882
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.05548530
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05386540
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05386540
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05138423
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04717515
105EWS_26573619_Chip-Seq_HEK293_Human1.03552738
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02826825
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02466355
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00592180
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.00185271
110AR_19668381_ChIP-Seq_PC3_Human0.98575106
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98542281
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.98387288
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.98144469
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98059103
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.97918056
116SOX9_26525672_Chip-Seq_HEART_Mouse0.96780494
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96545502
118CBP_20019798_ChIP-Seq_JUKART_Human0.96545502
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96444607
120KDM2B_26808549_Chip-Seq_REH_Human0.96439632
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94999688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.98580142
2MP0004859_abnormal_synaptic_plasticity4.14941987
3MP0004270_analgesia3.54317186
4MP0003635_abnormal_synaptic_transmissio3.41592541
5MP0001968_abnormal_touch/_nociception3.34289333
6MP0006276_abnormal_autonomic_nervous2.94241577
7MP0009745_abnormal_behavioral_response2.93977762
8MP0002063_abnormal_learning/memory/cond2.89316231
9MP0002736_abnormal_nociception_after2.89043514
10MP0002734_abnormal_mechanical_nocicepti2.87599465
11MP0002735_abnormal_chemical_nociception2.84528620
12MP0009046_muscle_twitch2.69327525
13MP0005423_abnormal_somatic_nervous2.68581978
14MP0002064_seizures2.65883795
15MP0002572_abnormal_emotion/affect_behav2.53398908
16MP0001984_abnormal_olfaction2.30857082
17MP0002272_abnormal_nervous_system2.29366047
18MP0000778_abnormal_nervous_system2.22327417
19MP0002184_abnormal_innervation2.17744701
20MP0001501_abnormal_sleep_pattern2.10992166
21MP0002733_abnormal_thermal_nociception2.08435277
22MP0001440_abnormal_grooming_behavior2.06701937
23MP0001486_abnormal_startle_reflex2.05527863
24MP0002067_abnormal_sensory_capabilities2.04226151
25MP0001970_abnormal_pain_threshold1.99002432
26MP0001188_hyperpigmentation1.91066842
27MP0001529_abnormal_vocalization1.80566104
28MP0004133_heterotaxia1.79945623
29MP0002557_abnormal_social/conspecific_i1.75029302
30MP0010386_abnormal_urinary_bladder1.72606484
31MP0004924_abnormal_behavior1.64394277
32MP0005386_behavior/neurological_phenoty1.64394277
33MP0003879_abnormal_hair_cell1.63994157
34MP0003890_abnormal_embryonic-extraembry1.61525292
35MP0008877_abnormal_DNA_methylation1.59473618
36MP0003122_maternal_imprinting1.59264255
37MP0004858_abnormal_nervous_system1.57258368
38MP0004811_abnormal_neuron_physiology1.57158853
39MP0005646_abnormal_pituitary_gland1.56897593
40MP0002938_white_spotting1.56794832
41MP0001905_abnormal_dopamine_level1.56552252
42MP0002822_catalepsy1.56085866
43MP0009780_abnormal_chondrocyte_physiolo1.53903141
44MP0003136_yellow_coat_color1.49039874
45MP0003787_abnormal_imprinting1.44088322
46MP0000566_synostosis1.42111274
47MP0002882_abnormal_neuron_morphology1.41677483
48MP0005394_taste/olfaction_phenotype1.41408994
49MP0005499_abnormal_olfactory_system1.41408994
50MP0005645_abnormal_hypothalamus_physiol1.39402911
51MP0006072_abnormal_retinal_apoptosis1.37130787
52MP0000955_abnormal_spinal_cord1.35104566
53MP0005253_abnormal_eye_physiology1.28602814
54MP0002837_dystrophic_cardiac_calcinosis1.25071440
55MP0008789_abnormal_olfactory_epithelium1.24978635
56MP0002876_abnormal_thyroid_physiology1.22360130
57MP0002066_abnormal_motor_capabilities/c1.20712457
58MP0008569_lethality_at_weaning1.18297301
59MP0000049_abnormal_middle_ear1.16051922
60MP0004142_abnormal_muscle_tone1.15206538
61MP0005171_absent_coat_pigmentation1.09964305
62MP0004742_abnormal_vestibular_system1.09576450
63MP0002234_abnormal_pharynx_morphology1.07542499
64MP0002152_abnormal_brain_morphology1.06957288
65MP0005623_abnormal_meninges_morphology1.06884433
66MP0000647_abnormal_sebaceous_gland1.05994195
67MP0000751_myopathy1.04836241
68MP0000631_abnormal_neuroendocrine_gland1.04570714
69MP0002751_abnormal_autonomic_nervous1.04315028
70MP0002233_abnormal_nose_morphology1.02289479
71MP0003937_abnormal_limbs/digits/tail_de1.01483014
72MP0000569_abnormal_digit_pigmentation1.00101378
73MP0001502_abnormal_circadian_rhythm1.00068782
74MP0002909_abnormal_adrenal_gland0.99406436
75MP0002752_abnormal_somatic_nervous0.98799247
76MP0001963_abnormal_hearing_physiology0.97837538
77MP0002928_abnormal_bile_duct0.95460486
78MP0003119_abnormal_digestive_system0.94889727
79MP0005195_abnormal_posterior_eye0.94485728
80MP0003938_abnormal_ear_development0.93620471
81MP0005248_abnormal_Harderian_gland0.93095318
82MP0001485_abnormal_pinna_reflex0.92400358
83MP0008995_early_reproductive_senescence0.91109019
84MP0004085_abnormal_heartbeat0.90336871
85MP0003283_abnormal_digestive_organ0.87010079
86MP0001986_abnormal_taste_sensitivity0.86700949
87MP0003755_abnormal_palate_morphology0.85898232
88MP0000026_abnormal_inner_ear0.83344187
89MP0001348_abnormal_lacrimal_gland0.82675787
90MP0005551_abnormal_eye_electrophysiolog0.81833682
91MP0003011_delayed_dark_adaptation0.80913303
92MP0003329_amyloid_beta_deposits0.80338883
93MP0001177_atelectasis0.80178514
94MP0002102_abnormal_ear_morphology0.79379334
95MP0001286_abnormal_eye_development0.79327339
96MP0002638_abnormal_pupillary_reflex0.78821827
97MP0006292_abnormal_olfactory_placode0.78513759
98MP0003633_abnormal_nervous_system0.77641364
99MP0003567_abnormal_fetal_cardiomyocyte0.75783072
100MP0002229_neurodegeneration0.75231899
101MP0003121_genomic_imprinting0.74683148
102MP0002069_abnormal_eating/drinking_beha0.74189243
103MP0001324_abnormal_eye_pigmentation0.74009566
104MP0008872_abnormal_physiological_respon0.72894371
105MP0002282_abnormal_trachea_morphology0.72348281
106MP0001664_abnormal_digestion0.72145456
107MP0000013_abnormal_adipose_tissue0.70586739
108MP0005391_vision/eye_phenotype0.70286847
109MP0003631_nervous_system_phenotype0.69894905
110MP0004233_abnormal_muscle_weight0.69593740
111MP0003861_abnormal_nervous_system0.69529061
112MP0001943_abnormal_respiration0.69436686
113MP0005084_abnormal_gallbladder_morpholo0.68687017
114MP0000538_abnormal_urinary_bladder0.67859864
115MP0002653_abnormal_ependyma_morphology0.67144006
116MP0003137_abnormal_impulse_conducting0.66723098
117MP0004484_altered_response_of0.66716930
118MP0000534_abnormal_ureter_morphology0.66458387
119MP0005187_abnormal_penis_morphology0.66079436
120MP0002160_abnormal_reproductive_system0.65998703
121MP0000372_irregular_coat_pigmentation0.61795024
122MP0003634_abnormal_glial_cell0.60970419
123MP0004215_abnormal_myocardial_fiber0.59582965
124MP0004885_abnormal_endolymph0.59036669
125MP0001299_abnormal_eye_distance/0.58517333
126MP0004145_abnormal_muscle_electrophysio0.57542418
127MP0005535_abnormal_body_temperature0.57027890

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.53154489
2Atonic seizures (HP:0010819)5.40042048
3Febrile seizures (HP:0002373)4.87824530
4Focal seizures (HP:0007359)4.85297864
5Epileptic encephalopathy (HP:0200134)4.84526867
6Myokymia (HP:0002411)4.69712120
7Absence seizures (HP:0002121)4.07772638
8Hyperventilation (HP:0002883)3.73329296
9Visual hallucinations (HP:0002367)3.71710088
10Dialeptic seizures (HP:0011146)3.71348160
11Progressive cerebellar ataxia (HP:0002073)3.66132754
12True hermaphroditism (HP:0010459)3.57771274
13Gait imbalance (HP:0002141)3.49660156
14Limb dystonia (HP:0002451)3.41980436
15Generalized tonic-clonic seizures (HP:0002069)3.37437749
16Hypothermia (HP:0002045)3.28959135
17Pancreatic cysts (HP:0001737)3.27881108
18Broad-based gait (HP:0002136)3.27089436
19Abnormality of midbrain morphology (HP:0002418)3.24513888
20Molar tooth sign on MRI (HP:0002419)3.24513888
21Amblyopia (HP:0000646)3.09244735
22Nephronophthisis (HP:0000090)3.06133506
23Medial flaring of the eyebrow (HP:0010747)3.05215905
24Congenital primary aphakia (HP:0007707)3.00362108
25Abnormal hair whorl (HP:0010721)2.99611630
26Nephrogenic diabetes insipidus (HP:0009806)2.84196096
27Drooling (HP:0002307)2.69683878
28Excessive salivation (HP:0003781)2.69683878
29Genital tract atresia (HP:0001827)2.65159637
30Insidious onset (HP:0003587)2.65054529
31Termporal pattern (HP:0011008)2.65054529
32Pheochromocytoma (HP:0002666)2.62167464
33Abnormality of the renal medulla (HP:0100957)2.60039700
34Specific learning disability (HP:0001328)2.57158352
35Protruding tongue (HP:0010808)2.56373680
36Vaginal atresia (HP:0000148)2.54146466
37Failure to thrive in infancy (HP:0001531)2.50561578
38Neuroendocrine neoplasm (HP:0100634)2.49511481
39Polyphagia (HP:0002591)2.48711439
40Acute necrotizing encephalopathy (HP:0006965)2.48271090
41Abnormal eating behavior (HP:0100738)2.46207325
42Progressive inability to walk (HP:0002505)2.38579637
43Abnormality of the corticospinal tract (HP:0002492)2.38461683
44Oligodactyly (hands) (HP:0001180)2.35291513
45Progressive macrocephaly (HP:0004481)2.35267312
46Rhinitis (HP:0012384)2.34594360
47Gaze-evoked nystagmus (HP:0000640)2.34286839
48Hypoventilation (HP:0002791)2.33734593
49Impaired vibration sensation in the lower limbs (HP:0002166)2.32503516
50Postaxial hand polydactyly (HP:0001162)2.32140053
51Retinal dysplasia (HP:0007973)2.30701200
52Action tremor (HP:0002345)2.28715321
53Fetal akinesia sequence (HP:0001989)2.27157246
54Abnormal mitochondria in muscle tissue (HP:0008316)2.26410716
55Epileptiform EEG discharges (HP:0011182)2.25295854
56Truncal ataxia (HP:0002078)2.24488795
57Abnormal ciliary motility (HP:0012262)2.23291496
58Ankle clonus (HP:0011448)2.22439279
59Absent speech (HP:0001344)2.22400574
60Hyperthyroidism (HP:0000836)2.22305623
61Narrow nasal bridge (HP:0000446)2.21587449
62Mutism (HP:0002300)2.21017409
63Exotropia (HP:0000577)2.20557676
64Type II lissencephaly (HP:0007260)2.19790009
65Shoulder girdle muscle weakness (HP:0003547)2.18470236
66Pachygyria (HP:0001302)2.17683837
67Optic nerve hypoplasia (HP:0000609)2.17569021
68Inability to walk (HP:0002540)2.16811386
69Lissencephaly (HP:0001339)2.14428049
70Abnormality of the renal cortex (HP:0011035)2.14363889
71Cystic liver disease (HP:0006706)2.13404713
72Absent/shortened dynein arms (HP:0200106)2.13231210
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.13231210
74Anencephaly (HP:0002323)2.11314059
75Chronic hepatic failure (HP:0100626)2.10817185
76Aplasia/Hypoplasia of the lens (HP:0008063)2.10667281
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.09289276
78Poor coordination (HP:0002370)2.09133602
79Abnormality of salivation (HP:0100755)2.08289931
80Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07017230
81Hypoplasia of the brainstem (HP:0002365)2.07017230
82Poor eye contact (HP:0000817)2.06119226
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.05907422
84EEG with generalized epileptiform discharges (HP:0011198)2.05177507
85Supranuclear gaze palsy (HP:0000605)2.05101929
86Intestinal atresia (HP:0011100)2.04659697
87Occipital encephalocele (HP:0002085)2.02715526
88Abnormality of the labia minora (HP:0012880)2.00054333
89Urinary bladder sphincter dysfunction (HP:0002839)1.99964085
90Narrow forehead (HP:0000341)1.99738227
91Impaired pain sensation (HP:0007328)1.99572347
92Abnormality of pain sensation (HP:0010832)1.99572347
93Sclerocornea (HP:0000647)1.99256371
94Abnormal respiratory motile cilium physiology (HP:0012261)1.98173613
95Ulnar claw (HP:0001178)1.97319712
96Genetic anticipation (HP:0003743)1.96890301
97Postaxial foot polydactyly (HP:0001830)1.96637459
98Decreased testicular size (HP:0008734)1.95647821
99Broad foot (HP:0001769)1.95280116
100Bradycardia (HP:0001662)1.93993317
101Akinesia (HP:0002304)1.93974837
102Short tibia (HP:0005736)1.93416211
103Blue irides (HP:0000635)1.92165024
104Anxiety (HP:0000739)1.91312310
105Depression (HP:0000716)1.91284793
106Renal cortical cysts (HP:0000803)1.90428782
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.90428371
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90428371
109Cortical dysplasia (HP:0002539)1.88807445
110Hypsarrhythmia (HP:0002521)1.88175250
111Esotropia (HP:0000565)1.87923388
112Abnormal respiratory epithelium morphology (HP:0012253)1.87738697
113Abnormal respiratory motile cilium morphology (HP:0005938)1.87738697
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86937428
115Dysdiadochokinesis (HP:0002075)1.85304503
116Preaxial hand polydactyly (HP:0001177)1.84278796
117Abnormality of binocular vision (HP:0011514)1.83769152
118Diplopia (HP:0000651)1.83769152
119Poor suck (HP:0002033)1.83751750
120Labial hypoplasia (HP:0000066)1.83659362
121Septo-optic dysplasia (HP:0100842)1.81476252
122Anophthalmia (HP:0000528)1.80735950
123Increased hepatocellular lipid droplets (HP:0006565)1.80552252
124Volvulus (HP:0002580)1.79992253
125Abnormality of the hip-girdle musculature (HP:0001445)1.79181517
126Abnormality of the musculature of the pelvis (HP:0001469)1.79181517
127Mitochondrial inheritance (HP:0001427)1.78274904
128Tubulointerstitial nephritis (HP:0001970)1.77180888
129Hemiparesis (HP:0001269)1.76829665
130Acute encephalopathy (HP:0006846)1.76744177
131Methylmalonic acidemia (HP:0002912)1.74769207
132Split foot (HP:0001839)1.74731146
133Torticollis (HP:0000473)1.73540711
134Increased CSF lactate (HP:0002490)1.72690918
135Pancreatic fibrosis (HP:0100732)1.72218472
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71765882
137Delayed gross motor development (HP:0002194)1.71451616
138Incomplete penetrance (HP:0003829)1.71401263
139Micropenis (HP:0000054)1.71060807
140Male pseudohermaphroditism (HP:0000037)1.70883413
141Tubulointerstitial abnormality (HP:0001969)1.70778007
142Short foot (HP:0001773)1.70672998
143Growth hormone deficiency (HP:0000824)1.69778280
144Impaired social interactions (HP:0000735)1.69741051
145Abnormal social behavior (HP:0012433)1.69741051
146Agitation (HP:0000713)1.69479163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.22984766
2MARK13.76178441
3MAP3K123.49846225
4NTRK33.21284524
5MAP2K73.11895718
6MAP3K42.88376391
7EPHA42.67720390
8MAP4K22.61398549
9MINK12.55904866
10PLK22.37382101
11MAP3K92.31928636
12DAPK22.27506061
13MAPK132.17311879
14TRIM281.92220408
15ARAF1.91875428
16ERBB31.84814773
17MAP2K41.81143374
18PINK11.80353777
19DAPK11.66270423
20NTRK21.64685884
21GRK51.61832520
22AKT31.56923903
23MAPK151.55660249
24SIK31.45243866
25CDK191.40596056
26BCR1.39607702
27NTRK11.29886492
28DYRK31.25407272
29PRKCG1.20043639
30CAMKK21.18971593
31KSR11.16409023
32CDK51.15851194
33DYRK21.15066751
34BMPR1B1.14768753
35BMPR21.13565942
36CCNB11.12159359
37RIPK41.09758974
38MKNK21.06929009
39TNIK1.06295074
40LATS21.05137859
41PRPF4B1.05120408
42PAK61.03029530
43FRK1.02218218
44CAMK2A1.00905978
45PHKG10.98574844
46PHKG20.98574844
47OXSR10.94744077
48PTK2B0.94663747
49PNCK0.93956660
50PRKCE0.93245711
51SGK4940.93037696
52SGK2230.93037696
53SGK20.92788627
54BRAF0.90848915
55GRK10.90723113
56LIMK10.90328906
57CSNK1G20.89689806
58STK390.89150740
59FER0.88495774
60FGFR20.87062177
61CAMK2B0.86944679
62MYLK0.86774458
63UHMK10.86537788
64PAK30.84658676
65CDK140.84380617
66CDK180.84287119
67NUAK10.83643128
68RPS6KA20.83317903
69SIK20.79147089
70CAMKK10.78344787
71TSSK60.78173255
72NME10.77980795
73KSR20.77342241
74VRK10.75822231
75CDK150.73747533
76INSRR0.73357685
77WEE10.70277754
78WNK40.69807004
79ADRBK10.69137837
80WNK30.66972500
81MAP2K10.66740538
82MKNK10.66090705
83DYRK1A0.64645495
84PKN10.64254059
85ADRBK20.62011997
86EPHB20.61458489
87CSNK1G30.60707096
88SRPK10.60600320
89CDK11A0.60307658
90ZAK0.59924382
91MAP3K20.55227273
92DAPK30.55004910
93MAP3K60.52849708
94YES10.52172230
95STK38L0.51570930
96FGR0.51118856
97TAF10.50252381
98RET0.49923239
99CDK30.48654680
100PLK30.46437952
101GRK70.46028154
102CAMK2D0.44483356
103ACVR1B0.44114175
104CSNK1E0.43764845
105RPS6KA40.43067799
106EPHA30.42896800
107BCKDK0.42805825
108PRKCZ0.42567217
109PDK40.41955385
110PDK30.41955385
111DYRK1B0.41606377
112CSNK1A10.41121758
113ROCK10.40997351
114PRKACB0.40125307
115PRKG10.40027547
116ROCK20.38995407
117TGFBR10.38814803
118MARK20.38559932
119CSNK1D0.37131290
120CAMK2G0.37001638
121SGK10.36490078
122FES0.35778282
123STK110.34325348
124NLK0.34303284
125RAF10.33868331
126CAMK40.33351260
127PRKACA0.33218684
128MAPK120.33187590
129SGK30.32511949
130CSNK1A1L0.32483971
131ERBB20.29703415
132RPS6KB10.28538804
133MAPKAPK50.28490296
134CAMK10.28189582
135STK160.27538785
136PLK40.27364641
137CSNK1G10.26113976

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78092532
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70763560
3Protein export_Homo sapiens_hsa030602.90095577
4Collecting duct acid secretion_Homo sapiens_hsa049662.85799984
5Olfactory transduction_Homo sapiens_hsa047402.76883748
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64152555
7GABAergic synapse_Homo sapiens_hsa047272.42942840
8Circadian entrainment_Homo sapiens_hsa047132.38257533
9Morphine addiction_Homo sapiens_hsa050322.31058534
10Amphetamine addiction_Homo sapiens_hsa050312.25092570
11Long-term potentiation_Homo sapiens_hsa047202.23671628
12Dopaminergic synapse_Homo sapiens_hsa047282.20648748
13Glutamatergic synapse_Homo sapiens_hsa047242.16262746
14Taste transduction_Homo sapiens_hsa047422.11643820
15Serotonergic synapse_Homo sapiens_hsa047261.97747690
16Oxidative phosphorylation_Homo sapiens_hsa001901.97571894
17Vibrio cholerae infection_Homo sapiens_hsa051101.88471605
18Cholinergic synapse_Homo sapiens_hsa047251.72017516
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71069753
20Salivary secretion_Homo sapiens_hsa049701.69177957
21Insulin secretion_Homo sapiens_hsa049111.68488355
22Renin secretion_Homo sapiens_hsa049241.66521099
23Steroid biosynthesis_Homo sapiens_hsa001001.65714529
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63916228
25Butanoate metabolism_Homo sapiens_hsa006501.59084475
26Basal transcription factors_Homo sapiens_hsa030221.56396290
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56196719
28Cocaine addiction_Homo sapiens_hsa050301.54765829
29Parkinsons disease_Homo sapiens_hsa050121.53848804
30Axon guidance_Homo sapiens_hsa043601.52724475
31Alzheimers disease_Homo sapiens_hsa050101.47206124
32Long-term depression_Homo sapiens_hsa047301.46871753
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.43291866
34Phototransduction_Homo sapiens_hsa047441.39980103
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39026316
36Gastric acid secretion_Homo sapiens_hsa049711.37516744
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36042125
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.35349075
39Oxytocin signaling pathway_Homo sapiens_hsa049211.34799424
40Calcium signaling pathway_Homo sapiens_hsa040201.34792539
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32700808
42Gap junction_Homo sapiens_hsa045401.28971876
43Regulation of autophagy_Homo sapiens_hsa041401.27253122
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24464387
45Cardiac muscle contraction_Homo sapiens_hsa042601.22792506
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18311962
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15231564
48GnRH signaling pathway_Homo sapiens_hsa049121.12999117
49Huntingtons disease_Homo sapiens_hsa050161.11082948
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08368642
51Linoleic acid metabolism_Homo sapiens_hsa005911.07803129
52Ether lipid metabolism_Homo sapiens_hsa005651.04054051
53Melanogenesis_Homo sapiens_hsa049161.01114214
54Rheumatoid arthritis_Homo sapiens_hsa053230.98566717
55Basal cell carcinoma_Homo sapiens_hsa052170.96807442
56ErbB signaling pathway_Homo sapiens_hsa040120.96547284
57cAMP signaling pathway_Homo sapiens_hsa040240.94954735
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92370985
59RNA degradation_Homo sapiens_hsa030180.92356699
60Phagosome_Homo sapiens_hsa041450.91041901
61Propanoate metabolism_Homo sapiens_hsa006400.90225201
62Estrogen signaling pathway_Homo sapiens_hsa049150.89955435
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85367393
64Peroxisome_Homo sapiens_hsa041460.84802660
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84353691
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83301983
67Oocyte meiosis_Homo sapiens_hsa041140.81810656
68Glioma_Homo sapiens_hsa052140.81755015
69Dilated cardiomyopathy_Homo sapiens_hsa054140.79513806
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.79145137
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77568428
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76479340
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75822311
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75491631
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74819689
76RNA polymerase_Homo sapiens_hsa030200.73515937
77Nitrogen metabolism_Homo sapiens_hsa009100.73156900
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72833404
79Type II diabetes mellitus_Homo sapiens_hsa049300.72218483
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71204474
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71053772
82MAPK signaling pathway_Homo sapiens_hsa040100.70582914
83Alcoholism_Homo sapiens_hsa050340.69301322
84Tryptophan metabolism_Homo sapiens_hsa003800.68585668
85Fanconi anemia pathway_Homo sapiens_hsa034600.67984439
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65772815
87Ras signaling pathway_Homo sapiens_hsa040140.65417304
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.61472210
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60566621
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58964983
91Wnt signaling pathway_Homo sapiens_hsa043100.58574127
92Melanoma_Homo sapiens_hsa052180.57553534
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56807386
94beta-Alanine metabolism_Homo sapiens_hsa004100.56655369
95Non-homologous end-joining_Homo sapiens_hsa034500.56176196
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56156606
97Chemical carcinogenesis_Homo sapiens_hsa052040.55814999
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53662510
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52307704
100Endometrial cancer_Homo sapiens_hsa052130.52208149
101Colorectal cancer_Homo sapiens_hsa052100.51960820
102Folate biosynthesis_Homo sapiens_hsa007900.51435025
103Selenocompound metabolism_Homo sapiens_hsa004500.50628919
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50493543
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.49626779
106Rap1 signaling pathway_Homo sapiens_hsa040150.48484384
107Thyroid hormone synthesis_Homo sapiens_hsa049180.47295442
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47137057
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46095221
110Glucagon signaling pathway_Homo sapiens_hsa049220.45105029
111Hedgehog signaling pathway_Homo sapiens_hsa043400.44903892
112Pancreatic secretion_Homo sapiens_hsa049720.44276561
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44029577
114Dorso-ventral axis formation_Homo sapiens_hsa043200.43996902
115Retinol metabolism_Homo sapiens_hsa008300.43899846
116Circadian rhythm_Homo sapiens_hsa047100.42865533
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42677970
118Caffeine metabolism_Homo sapiens_hsa002320.41785926
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41599330
120Type I diabetes mellitus_Homo sapiens_hsa049400.41200364
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.40093806
122Metabolic pathways_Homo sapiens_hsa011000.38889052
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38758000
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38096765
125TGF-beta signaling pathway_Homo sapiens_hsa043500.37785595
126Choline metabolism in cancer_Homo sapiens_hsa052310.36597328
127Histidine metabolism_Homo sapiens_hsa003400.36153580
128Insulin signaling pathway_Homo sapiens_hsa049100.35914785
129Renal cell carcinoma_Homo sapiens_hsa052110.35466386
130Hippo signaling pathway_Homo sapiens_hsa043900.35164433
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34627764
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33305369
133Proteasome_Homo sapiens_hsa030500.32899073
134Tight junction_Homo sapiens_hsa045300.32016933
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.32014808
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.31851118
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31198255
138African trypanosomiasis_Homo sapiens_hsa051430.31050123
139Prion diseases_Homo sapiens_hsa050200.30624718
140mTOR signaling pathway_Homo sapiens_hsa041500.29996168
141Endocytosis_Homo sapiens_hsa041440.29389333
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29275020

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