ZC2HC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.81418771
2piRNA metabolic process (GO:0034587)8.32852568
3regulation of meiosis I (GO:0060631)8.17486907
4meiotic cell cycle (GO:0051321)7.95776173
5regulation of acrosome reaction (GO:0060046)7.48391746
6multicellular organism reproduction (GO:0032504)7.36249317
7DNA methylation involved in gamete generation (GO:0043046)6.94628337
8retinal cone cell development (GO:0046549)6.84052546
9centriole replication (GO:0007099)6.61447066
10positive regulation of histone H3-K4 methylation (GO:0051571)6.42096490
11oocyte development (GO:0048599)6.37040268
12regulation of histone H3-K9 methylation (GO:0051570)6.31021189
13positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.04391695
14positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.04391695
15positive regulation of mitotic sister chromatid separation (GO:1901970)6.04391695
16female gamete generation (GO:0007292)5.96656487
17glycine transport (GO:0015816)5.35222265
18negative regulation of histone methylation (GO:0031061)5.33909829
19regulation of steroid hormone secretion (GO:2000831)5.24259198
20reproduction (GO:0000003)5.11583845
21regulation of cell maturation (GO:1903429)5.06790915
22negative regulation of reproductive process (GO:2000242)5.05184198
23positive regulation of gastrulation (GO:2000543)4.91702175
24male meiosis I (GO:0007141)4.88916952
25centriole assembly (GO:0098534)4.85418232
26positive regulation of chromosome segregation (GO:0051984)4.81544192
27protein kinase C signaling (GO:0070528)4.72895538
28gene silencing by RNA (GO:0031047)4.72470082
29synapsis (GO:0007129)4.61096135
30fertilization (GO:0009566)4.36610171
31mitotic metaphase plate congression (GO:0007080)4.33208214
32male meiosis (GO:0007140)4.31216448
33mitotic chromosome condensation (GO:0007076)4.27127186
34chromosome organization involved in meiosis (GO:0070192)4.25288278
35establishment of chromosome localization (GO:0051303)4.16273451
36positive regulation of histone methylation (GO:0031062)4.14851260
37single fertilization (GO:0007338)4.13362514
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11268909
39protein localization to chromosome, centromeric region (GO:0071459)4.05356314
40positive regulation of humoral immune response (GO:0002922)4.04442393
41synaptonemal complex assembly (GO:0007130)4.03780004
42binding of sperm to zona pellucida (GO:0007339)3.97165745
43regulation of meiosis (GO:0040020)3.95744221
44meiotic nuclear division (GO:0007126)3.92432236
45protein localization to kinetochore (GO:0034501)3.91133222
46meiosis I (GO:0007127)3.86660966
47microtubule severing (GO:0051013)3.85007660
48primitive streak formation (GO:0090009)3.80378633
49oogenesis (GO:0048477)3.77873361
50regulation of histone H3-K4 methylation (GO:0051569)3.76492503
51sperm-egg recognition (GO:0035036)3.71967595
52meiotic cell cycle process (GO:1903046)3.71896577
53L-amino acid import (GO:0043092)3.69896244
54synaptonemal complex organization (GO:0070193)3.66354304
55somite rostral/caudal axis specification (GO:0032525)3.55783712
56labyrinthine layer development (GO:0060711)3.54436763
57attachment of spindle microtubules to kinetochore (GO:0008608)3.54111190
58negative regulation of execution phase of apoptosis (GO:1900118)3.50970066
59DNA methylation (GO:0006306)3.50603792
60DNA alkylation (GO:0006305)3.50603792
61regulation of chromatin silencing (GO:0031935)3.49690045
62nucleus organization (GO:0006997)3.47460379
63metaphase plate congression (GO:0051310)3.43780224
64regulation of histone methylation (GO:0031060)3.42970789
65negative regulation of cAMP-mediated signaling (GO:0043951)3.42334062
66positive regulation of uterine smooth muscle contraction (GO:0070474)3.41857505
67gene silencing (GO:0016458)3.34143246
68protein polyglutamylation (GO:0018095)3.33614358
69cellular response to pH (GO:0071467)3.32190788
70sperm motility (GO:0030317)3.30376809
71spermatid development (GO:0007286)3.28460213
72phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.27982504
73translesion synthesis (GO:0019985)3.27517397
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26941820
75regulation of meiotic cell cycle (GO:0051445)3.26918242
76acrosome reaction (GO:0007340)3.25216739
77positive regulation of reproductive process (GO:2000243)3.24916625
78cilium or flagellum-dependent cell motility (GO:0001539)3.24617882
79regulation of steroid hormone biosynthetic process (GO:0090030)3.23134109
80response to acidic pH (GO:0010447)3.21752462
81centrosome duplication (GO:0051298)3.20187955
82CENP-A containing nucleosome assembly (GO:0034080)3.19228660
83chromosome condensation (GO:0030261)3.18174665
84regulation of reproductive process (GO:2000241)3.17945210
85germ cell development (GO:0007281)3.15071909
86protein localization to chromosome (GO:0034502)3.12757277
87positive regulation of meiosis (GO:0045836)3.12437474
88spermatid nucleus differentiation (GO:0007289)3.11849392
89histone exchange (GO:0043486)3.11816786
90nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.11206606
91phosphorelay signal transduction system (GO:0000160)3.09504398
92DNA damage induced protein phosphorylation (GO:0006975)3.09013208
93neuron fate determination (GO:0048664)3.08334520
94spermatogenesis (GO:0007283)3.08321677
95male gamete generation (GO:0048232)3.07137151
96sperm capacitation (GO:0048240)3.06592930
97relaxation of smooth muscle (GO:0044557)3.06579721
98regulation of spindle organization (GO:0090224)3.05544350
99gamete generation (GO:0007276)3.05389713
100regulation of DNA methylation (GO:0044030)10.5568999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.89819719
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.91079857
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.68047104
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.16001144
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00929603
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87753077
7E2F7_22180533_ChIP-Seq_HELA_Human2.77335975
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56914784
9GBX2_23144817_ChIP-Seq_PC3_Human2.34205107
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29458591
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20274140
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20274140
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20274140
14EZH2_22144423_ChIP-Seq_EOC_Human12.9006524
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67254932
16CBP_20019798_ChIP-Seq_JUKART_Human1.66484504
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66484504
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.64578763
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61150223
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.49321467
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47702278
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.45637766
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45455158
24TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42812623
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40806789
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40101375
27PRDM14_20953172_ChIP-Seq_ESCs_Human1.37553923
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36558994
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34268158
30AR_25329375_ChIP-Seq_VCAP_Human1.32337761
31TCF4_23295773_ChIP-Seq_U87_Human1.31254180
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31236059
33SMAD4_21741376_ChIP-Seq_EPCs_Human1.26231775
34SMAD4_21799915_ChIP-Seq_A2780_Human1.25028192
35NANOG_20526341_ChIP-Seq_ESCs_Human1.23613799
36ZNF274_21170338_ChIP-Seq_K562_Hela1.21755236
37HTT_18923047_ChIP-ChIP_STHdh_Human1.21725351
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14080325
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12037076
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.11892195
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11812264
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10958557
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10958557
44STAT3_23295773_ChIP-Seq_U87_Human1.06461208
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.06028240
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.05986754
47IRF1_19129219_ChIP-ChIP_H3396_Human1.04838898
48RUNX2_22187159_ChIP-Seq_PCA_Human1.01042688
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00520128
50ER_23166858_ChIP-Seq_MCF-7_Human0.99591467
51FOXH1_21741376_ChIP-Seq_EPCs_Human0.99196559
52P300_19829295_ChIP-Seq_ESCs_Human0.98388163
53EWS_26573619_Chip-Seq_HEK293_Human0.97803088
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97126529
55SALL4_22934838_ChIP-ChIP_CD34+_Human0.97078374
56SMRT_27268052_Chip-Seq_Bcells_Human0.95827484
57E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95246390
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95213733
59ERG_20517297_ChIP-Seq_VCAP_Human0.95140816
60CBP_21632823_ChIP-Seq_H3396_Human0.93837050
61GF1_26923725_Chip-Seq_HPCs_Mouse0.93834692
62AHR_22903824_ChIP-Seq_MCF-7_Human0.92746591
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92639066
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91737894
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91287335
66FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90256910
67CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89565237
68GATA3_26560356_Chip-Seq_TH1_Human0.88541027
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87439122
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87196844
71BCAT_22108803_ChIP-Seq_LS180_Human0.86585048
72TAL1_26923725_Chip-Seq_HPCs_Mouse0.86387742
73ARNT_22903824_ChIP-Seq_MCF-7_Human0.85618433
74DROSHA_22980978_ChIP-Seq_HELA_Human0.84676049
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82869917
76TAF15_26573619_Chip-Seq_HEK293_Human0.82645312
77FUS_26573619_Chip-Seq_HEK293_Human0.82421888
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82279185
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.82279185
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79878248
81GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79600654
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78943772
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78731812
84SOX2_19829295_ChIP-Seq_ESCs_Human0.78509070
85NANOG_19829295_ChIP-Seq_ESCs_Human0.78509070
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76951455
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76929613
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.74748166
89KDM2B_26808549_Chip-Seq_REH_Human0.74301106
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74262233
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73742680
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72377679
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.72283313
94AR_20517297_ChIP-Seq_VCAP_Human0.72068258
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70382199
96AR_21909140_ChIP-Seq_LNCAP_Human0.70343691
97REST_21632747_ChIP-Seq_MESCs_Mouse0.70249653
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.69823548
99CDX2_22108803_ChIP-Seq_LS180_Human0.69612470
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.67682793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.13848968
2MP0008877_abnormal_DNA_methylation5.40478389
3MP0010234_abnormal_vibrissa_follicle4.32441004
4MP0008789_abnormal_olfactory_epithelium3.99233373
5MP0006292_abnormal_olfactory_placode3.96080689
6MP0002139_abnormal_hepatobiliary_system3.76976617
7MP0002138_abnormal_hepatobiliary_system3.73208661
8MP0005410_abnormal_fertilization3.72342568
9MP0005499_abnormal_olfactory_system3.48409067
10MP0005394_taste/olfaction_phenotype3.48409067
11MP0005395_other_phenotype3.36108704
12MP0003890_abnormal_embryonic-extraembry3.03234014
13MP0001929_abnormal_gametogenesis2.63670563
14MP0003693_abnormal_embryo_hatching2.63575343
15MP0005360_urolithiasis2.40135533
16MP0003879_abnormal_hair_cell2.38890726
17MP0008057_abnormal_DNA_replication2.27949621
18MP0003699_abnormal_female_reproductive2.24604596
19MP0002210_abnormal_sex_determination2.16597323
20MP0002234_abnormal_pharynx_morphology2.10809097
21MP0003183_abnormal_peptide_metabolism1.97883340
22MP0010030_abnormal_orbit_morphology1.84494214
23MP0002160_abnormal_reproductive_system1.83731594
24MP0002161_abnormal_fertility/fecundity1.83356036
25MP0003698_abnormal_male_reproductive1.78116800
26MP0000653_abnormal_sex_gland1.77243485
27MP0003077_abnormal_cell_cycle1.75294521
28MP0001984_abnormal_olfaction1.69432429
29MP0010094_abnormal_chromosome_stability1.65218980
30MP0008058_abnormal_DNA_repair1.62692148
31MP0003950_abnormal_plasma_membrane1.61071641
32MP0003252_abnormal_bile_duct1.56777024
33MP0001145_abnormal_male_reproductive1.47895480
34MP0010307_abnormal_tumor_latency1.36589217
35MP0009840_abnormal_foam_cell1.34684841
36MP0010368_abnormal_lymphatic_system1.33470275
37MP0005647_abnormal_sex_gland1.27253801
38MP0003121_genomic_imprinting1.22423075
39MP0001119_abnormal_female_reproductive1.21076042
40MP0000566_synostosis1.19145870
41MP0005551_abnormal_eye_electrophysiolog1.18856393
42MP0005389_reproductive_system_phenotype1.16110918
43MP0005085_abnormal_gallbladder_physiolo1.13998735
44MP0002638_abnormal_pupillary_reflex1.11961716
45MP0003111_abnormal_nucleus_morphology1.10752241
46MP0005646_abnormal_pituitary_gland1.09693431
47MP0008932_abnormal_embryonic_tissue1.07345207
48MP0000427_abnormal_hair_cycle1.04194873
49MP0000631_abnormal_neuroendocrine_gland1.04169784
50MP0001986_abnormal_taste_sensitivity0.96356530
51MP0001730_embryonic_growth_arrest0.92731679
52MP0010678_abnormal_skin_adnexa0.91771313
53MP0000762_abnormal_tongue_morphology0.91041139
54MP0002928_abnormal_bile_duct0.89029343
55MP0001963_abnormal_hearing_physiology0.88285957
56MP0002272_abnormal_nervous_system0.86533840
57MP0001293_anophthalmia0.84154591
58MP0005645_abnormal_hypothalamus_physiol0.75507141
59MP0004142_abnormal_muscle_tone0.74189168
60MP0006276_abnormal_autonomic_nervous0.73793435
61MP0002233_abnormal_nose_morphology0.73632802
62MP0002127_abnormal_cardiovascular_syste0.70234591
63MP0001664_abnormal_digestion0.68679057
64MP0002796_impaired_skin_barrier0.65614424
65MP0003880_abnormal_central_pattern0.65153654
66MP0000678_abnormal_parathyroid_gland0.64199983
67MP0002163_abnormal_gland_morphology0.60176055
68MP0001672_abnormal_embryogenesis/_devel0.57168557
69MP0005380_embryogenesis_phenotype0.57168557
70MP0004957_abnormal_blastocyst_morpholog0.55718768
71MP0003119_abnormal_digestive_system0.55500826
72MP0000049_abnormal_middle_ear0.52920400
73MP0001881_abnormal_mammary_gland0.49803929
74MP0004084_abnormal_cardiac_muscle0.49417606
75MP0000350_abnormal_cell_proliferation0.48604664
76MP0000026_abnormal_inner_ear0.46778928
77MP0005310_abnormal_salivary_gland0.45342529
78MP0002735_abnormal_chemical_nociception0.45284072
79MP0001324_abnormal_eye_pigmentation0.43724064
80MP0003195_calcinosis0.42968807
81MP0003868_abnormal_feces_composition0.42735120
82MP0001348_abnormal_lacrimal_gland0.42534311
83MP0000015_abnormal_ear_pigmentation0.40837368
84MP0001545_abnormal_hematopoietic_system0.40515883
85MP0005397_hematopoietic_system_phenotyp0.40515883
86MP0004043_abnormal_pH_regulation0.39953101
87MP0001666_abnormal_nutrient_absorption0.38831221
88MP0003787_abnormal_imprinting0.38758404
89MP0005503_abnormal_tendon_morphology0.38560909
90MP0002229_neurodegeneration0.37990093
91MP0005253_abnormal_eye_physiology0.34404038
92MP0008775_abnormal_heart_ventricle0.33944428
93MP0005319_abnormal_enzyme/_coenzyme0.33103477
94MP0009379_abnormal_foot_pigmentation0.33052480
95MP0002084_abnormal_developmental_patter0.32379168
96MP0000313_abnormal_cell_death0.32186783
97MP0005379_endocrine/exocrine_gland_phen0.31387230
98MP0005501_abnormal_skin_physiology0.31060825
99MP0001944_abnormal_pancreas_morphology0.30697561
100MP0001765_abnormal_ion_homeostasis0.30297382

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.41143174
2Abnormality of abdominal situs (HP:0011620)4.95439759
3Abdominal situs inversus (HP:0003363)4.95439759
4Impulsivity (HP:0100710)4.88283923
5Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.84808536
6Hypophosphatemic rickets (HP:0004912)4.61560603
7Osteomalacia (HP:0002749)4.26831446
8Male infertility (HP:0003251)4.26540222
9Facial hemangioma (HP:0000329)4.24108095
10Abnormal gallbladder physiology (HP:0012438)4.23641436
11Cholecystitis (HP:0001082)4.23641436
12Chromsome breakage (HP:0040012)4.06001552
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94937154
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.87588125
15Hypoplasia of the fovea (HP:0007750)3.87588125
16Infertility (HP:0000789)3.86100395
17Lip pit (HP:0100267)3.84049603
18Anterior segment dysgenesis (HP:0007700)3.80555106
19Oligodactyly (hands) (HP:0001180)3.78068657
20Azoospermia (HP:0000027)3.76213178
21Enlarged penis (HP:0000040)3.60160860
22Septo-optic dysplasia (HP:0100842)3.42464320
23Abnormality of the fovea (HP:0000493)3.31378850
24Abnormality of the labia minora (HP:0012880)3.22660033
25Median cleft lip (HP:0000161)3.20270670
26Urethral obstruction (HP:0000796)3.16262675
27Gonadotropin excess (HP:0000837)3.11163674
28Papillary thyroid carcinoma (HP:0002895)3.04119763
29Congenital sensorineural hearing impairment (HP:0008527)3.03028597
30Abnormal spermatogenesis (HP:0008669)2.99960769
31Absent septum pellucidum (HP:0001331)2.99790759
32Malnutrition (HP:0004395)2.94410991
33Attenuation of retinal blood vessels (HP:0007843)2.93158857
34Abnormal ciliary motility (HP:0012262)2.87389721
35Absent/shortened dynein arms (HP:0200106)2.82154688
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.82154688
37Abnormality of the septum pellucidum (HP:0007375)2.81064803
38Oligodactyly (HP:0012165)2.71952727
39Short tibia (HP:0005736)2.70957159
40Wrist flexion contracture (HP:0001239)2.66789625
41Stillbirth (HP:0003826)2.60019318
42Severe visual impairment (HP:0001141)2.59836085
43Metaphyseal irregularity (HP:0003025)2.55967740
44Truncal obesity (HP:0001956)2.49570858
45Bile duct proliferation (HP:0001408)2.49463948
46Abnormal biliary tract physiology (HP:0012439)2.49463948
47Generalized aminoaciduria (HP:0002909)2.48183001
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44785647
49Capillary hemangiomas (HP:0005306)2.43981495
50Bony spicule pigmentary retinopathy (HP:0007737)2.43509695
51Subcapsular cataract (HP:0000523)2.42122501
52Abnormal respiratory motile cilium physiology (HP:0012261)2.41394331
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.40665702
54Muscle stiffness (HP:0003552)2.38094628
55Fair hair (HP:0002286)2.37469429
56Premature ovarian failure (HP:0008209)2.37433957
57Bundle branch block (HP:0011710)2.36539896
58Tubulointerstitial nephritis (HP:0001970)2.35869897
59Aplasia/Hypoplasia of the macula (HP:0008059)2.33598998
60Hypokinesia (HP:0002375)2.30276692
61Cone-rod dystrophy (HP:0000548)2.29725968
62Apathy (HP:0000741)2.25686631
63Intrahepatic cholestasis (HP:0001406)2.25510862
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.24685868
65Increased circulating renin level (HP:0000848)2.23535152
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.23048156
67Chronic hepatic failure (HP:0100626)2.22742143
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21747206
69Dysdiadochokinesis (HP:0002075)2.20960635
70Decreased central vision (HP:0007663)2.18809436
71Diminished motivation (HP:0000745)2.18483692
72Aplasia of the musculature (HP:0100854)2.16748642
73Skin pits (HP:0100276)2.14491028
74Meckel diverticulum (HP:0002245)2.14012852
75Proximal tubulopathy (HP:0000114)2.12195699
76Aplasia/Hypoplasia affecting the retina (HP:0008061)2.12171322
77Abnormality of the ileum (HP:0001549)2.08074994
78Abnormality of the preputium (HP:0100587)2.04987871
79Cranial hyperostosis (HP:0004437)2.04069020
80Thyroid carcinoma (HP:0002890)2.03253187
81Myokymia (HP:0002411)2.02325279
82Abnormality of chromosome stability (HP:0003220)2.02313494
83Conjunctival telangiectasia (HP:0000524)1.98366257
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96510056
85Hypergonadotropic hypogonadism (HP:0000815)1.96070284
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96010553
87Rhinitis (HP:0012384)1.92240699
88Duodenal stenosis (HP:0100867)1.91219955
89Small intestinal stenosis (HP:0012848)1.91219955
90Gaze-evoked nystagmus (HP:0000640)1.89141186
91Abnormality of the phalanges of the hallux (HP:0010057)1.88059584
92Clubbing of toes (HP:0100760)1.87298833
93Impaired smooth pursuit (HP:0007772)1.86525227
94Spinal cord compression (HP:0002176)1.85616031
95Bicornuate uterus (HP:0000813)1.84202396
96Lower limb hyperreflexia (HP:0002395)1.84058745
97Heterotopia (HP:0002282)1.82383266
98Abnormality of chromosome segregation (HP:0002916)1.81254738
99Aplastic anemia (HP:0001915)1.80335612
100Hip contracture (HP:0003273)1.80185005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF6.05682619
2MAP3K95.89163388
3MAP3K135.80378242
4NEK63.13008327
5BRAF3.12179543
6PLK42.96823851
7CDK92.48340136
8STK242.47003353
9MOS2.46248264
10TAOK32.38561309
11MET2.28837158
12TTK2.13456624
13MST42.13411814
14KSR22.02863694
15TNIK1.99488561
16FRK1.98479135
17CDK121.92312573
18CDC71.88908897
19RAF11.80946822
20AURKA1.75553901
21EIF2AK31.61239088
22PRKCI1.55688358
23ZAK1.52745982
24CDK71.48477249
25STK391.41712773
26STK31.35110283
27NTRK21.25311960
28TIE11.20253183
29PLK11.11979463
30MAP3K81.05033695
31KSR11.03336842
32PLK31.01440521
33NEK90.99906056
34MELK0.94391859
35TRIM280.93864189
36BRSK20.91123539
37OXSR10.87418962
38MAPKAPK30.81475496
39NUAK10.79412479
40NEK20.78092968
41BRSK10.77870458
42FGFR20.77196711
43PIM10.76255778
44PBK0.76247138
45CHEK10.72688918
46TNK20.66265385
47CDK20.65431929
48STK380.64714194
49VRK10.61331074
50MAPK110.58946064
51CHEK20.57794606
52PRKG10.57455180
53ATM0.50700046
54MARK30.50488992
55PDK10.49240542
56NTRK30.49186651
57INSRR0.47801718
58PRKCZ0.44357604
59PAK10.43949337
60CDK10.43689653
61CSNK1D0.43411251
62PKN10.41429142
63WNK40.40911142
64AKT20.39626183
65CDK30.39130755
66AURKB0.38943050
67SRPK10.38781594
68WNK10.37069114
69CHUK0.36125435
70BRD40.35629441
71BCKDK0.35310942
72CAMK1G0.33638534
73ATR0.32520123
74MST1R0.32454642
75BMPR1B0.32293603
76CSNK1G10.30647388
77AKT30.29339029
78PLK20.29302341
79TLK10.29103628
80MAPK10.28709537
81PRKCQ0.28700950
82PRKACA0.28441201
83PDPK10.28028846
84PRKACB0.27396968
85CDK80.27388213
86TGFBR10.26478818
87TRPM70.26211419
88BUB10.24421943
89CAMK2A0.23918150
90CAMK10.23185841
91PIK3CG0.23026999
92GSK3B0.23017772
93CSF1R0.22641847
94LRRK20.22412128
95MTOR0.22264079
96NLK0.20079333
97CSNK1E0.18845753
98WNK30.17973950
99MAP3K10.16896343
100CDK190.16445683

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.19797679
2Cell cycle_Homo sapiens_hsa041103.90278841
3Caffeine metabolism_Homo sapiens_hsa002323.52355510
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.41784055
5Oocyte meiosis_Homo sapiens_hsa041143.32742223
6Ovarian steroidogenesis_Homo sapiens_hsa049133.17748556
7Homologous recombination_Homo sapiens_hsa034402.97872136
8Mismatch repair_Homo sapiens_hsa034302.85995280
9RNA degradation_Homo sapiens_hsa030182.79310354
10Dorso-ventral axis formation_Homo sapiens_hsa043202.78854021
11Olfactory transduction_Homo sapiens_hsa047402.67516949
12Fanconi anemia pathway_Homo sapiens_hsa034602.60681455
13Phototransduction_Homo sapiens_hsa047442.56865963
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.47283803
15Base excision repair_Homo sapiens_hsa034102.33541222
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16107626
17DNA replication_Homo sapiens_hsa030302.00033823
18Nucleotide excision repair_Homo sapiens_hsa034201.79781962
19RNA transport_Homo sapiens_hsa030131.72079830
20RNA polymerase_Homo sapiens_hsa030201.68010508
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.64040806
22p53 signaling pathway_Homo sapiens_hsa041151.61464332
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55831204
24Circadian rhythm_Homo sapiens_hsa047101.53735067
25ABC transporters_Homo sapiens_hsa020101.47612454
26Folate biosynthesis_Homo sapiens_hsa007901.36496370
27Fatty acid elongation_Homo sapiens_hsa000621.31585200
28Nicotine addiction_Homo sapiens_hsa050331.21654370
29Thyroid cancer_Homo sapiens_hsa052161.21413063
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21375568
31Fatty acid biosynthesis_Homo sapiens_hsa000611.18059774
32Inositol phosphate metabolism_Homo sapiens_hsa005621.15936632
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13413392
34Gap junction_Homo sapiens_hsa045401.02998789
35Taste transduction_Homo sapiens_hsa047421.01468668
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99179072
37Morphine addiction_Homo sapiens_hsa050320.95218609
38Glycosaminoglycan degradation_Homo sapiens_hsa005310.90911862
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79846797
40GABAergic synapse_Homo sapiens_hsa047270.79695702
41Bile secretion_Homo sapiens_hsa049760.77886794
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73886163
43mTOR signaling pathway_Homo sapiens_hsa041500.73295314
44Purine metabolism_Homo sapiens_hsa002300.68818565
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65510732
46Long-term depression_Homo sapiens_hsa047300.62111108
47Linoleic acid metabolism_Homo sapiens_hsa005910.61050876
48Serotonergic synapse_Homo sapiens_hsa047260.59968109
49Arginine biosynthesis_Homo sapiens_hsa002200.59851784
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.58525361
51Synaptic vesicle cycle_Homo sapiens_hsa047210.58493046
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57594944
53Huntingtons disease_Homo sapiens_hsa050160.55359156
54Propanoate metabolism_Homo sapiens_hsa006400.55241513
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53362822
56Herpes simplex infection_Homo sapiens_hsa051680.52345884
57FoxO signaling pathway_Homo sapiens_hsa040680.51892455
58Regulation of autophagy_Homo sapiens_hsa041400.50157919
59mRNA surveillance pathway_Homo sapiens_hsa030150.49121638
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46417421
61Fatty acid metabolism_Homo sapiens_hsa012120.46193292
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.44498938
63TGF-beta signaling pathway_Homo sapiens_hsa043500.40674509
64Vitamin digestion and absorption_Homo sapiens_hsa049770.37767593
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36396835
66Influenza A_Homo sapiens_hsa051640.31898824
67MicroRNAs in cancer_Homo sapiens_hsa052060.31536766
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.31485823
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30200210
70Calcium signaling pathway_Homo sapiens_hsa040200.29858658
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28070688
72Viral carcinogenesis_Homo sapiens_hsa052030.25802749
73Oxytocin signaling pathway_Homo sapiens_hsa049210.23872725
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22769784
75Autoimmune thyroid disease_Homo sapiens_hsa053200.22726072
76Cardiac muscle contraction_Homo sapiens_hsa042600.22593898
77Ether lipid metabolism_Homo sapiens_hsa005650.20606307
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20588398
79Protein digestion and absorption_Homo sapiens_hsa049740.19167815
80cAMP signaling pathway_Homo sapiens_hsa040240.19138282
81Non-homologous end-joining_Homo sapiens_hsa034500.18955911
82HTLV-I infection_Homo sapiens_hsa051660.18781859
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18736662
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16086689
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14612789
86Ras signaling pathway_Homo sapiens_hsa040140.13673000
87Type I diabetes mellitus_Homo sapiens_hsa049400.13277030
88Asthma_Homo sapiens_hsa053100.12066240
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11895936
90Allograft rejection_Homo sapiens_hsa053300.11808025
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11352821
92Metabolic pathways_Homo sapiens_hsa011000.11343293
93Arachidonic acid metabolism_Homo sapiens_hsa005900.10892068
94Glutamatergic synapse_Homo sapiens_hsa047240.08904302
95Cholinergic synapse_Homo sapiens_hsa047250.07486759
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06775975
97Circadian entrainment_Homo sapiens_hsa047130.06737196
98Pyrimidine metabolism_Homo sapiens_hsa002400.06424645
99Pyruvate metabolism_Homo sapiens_hsa006200.06027149
100Renin-angiotensin system_Homo sapiens_hsa046140.05933310

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