ZC3H10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.76358429
2acrosome reaction (GO:0007340)7.09707407
3response to pheromone (GO:0019236)6.09199978
4multicellular organism reproduction (GO:0032504)5.75694629
5protein polyglutamylation (GO:0018095)5.73898845
6fusion of sperm to egg plasma membrane (GO:0007342)5.57819452
7spermatid nucleus differentiation (GO:0007289)5.34475658
8spermatid development (GO:0007286)5.33369555
9centriole replication (GO:0007099)5.15691194
10establishment of protein localization to Golgi (GO:0072600)4.99677009
11single strand break repair (GO:0000012)4.89586739
12sperm-egg recognition (GO:0035036)4.87038120
13epithelial cilium movement (GO:0003351)4.85802538
14protein targeting to Golgi (GO:0000042)4.80635508
15microtubule depolymerization (GO:0007019)4.78653957
16DNA deamination (GO:0045006)4.74269417
17cilium or flagellum-dependent cell motility (GO:0001539)4.63966304
18cellular ketone body metabolic process (GO:0046950)4.61710451
19rRNA methylation (GO:0031167)4.54174430
20reproduction (GO:0000003)4.37742324
21axonemal dynein complex assembly (GO:0070286)4.33495420
22retrograde transport, vesicle recycling within Golgi (GO:0000301)4.31833080
23centriole assembly (GO:0098534)4.29928770
24phosphatidylethanolamine biosynthetic process (GO:0006646)4.27261710
25plasma membrane fusion (GO:0045026)4.23827337
26regulation of cilium movement (GO:0003352)4.22688645
27phosphatidylethanolamine metabolic process (GO:0046337)4.18259711
28protein localization to Golgi apparatus (GO:0034067)4.10202636
29ketone body metabolic process (GO:1902224)4.09181098
30behavioral response to nicotine (GO:0035095)4.06503440
31cilium movement (GO:0003341)4.03447442
32cell-cell recognition (GO:0009988)4.03437696
33microtubule polymerization or depolymerization (GO:0031109)4.03016049
34spermatogenesis (GO:0007283)3.91183858
35male gamete generation (GO:0048232)3.90840205
36calcium ion-dependent exocytosis (GO:0017156)3.89474747
37sperm capacitation (GO:0048240)3.88745994
38rRNA modification (GO:0000154)3.82488871
39binding of sperm to zona pellucida (GO:0007339)3.76006465
40axoneme assembly (GO:0035082)3.67217290
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63351331
42dosage compensation (GO:0007549)3.61427710
43gamete generation (GO:0007276)3.59771362
44neural tube formation (GO:0001841)3.58898285
45detection of light stimulus involved in visual perception (GO:0050908)3.54464977
46detection of light stimulus involved in sensory perception (GO:0050962)3.54464977
47seminiferous tubule development (GO:0072520)3.52395753
48indole-containing compound catabolic process (GO:0042436)3.51617186
49indolalkylamine catabolic process (GO:0046218)3.51617186
50tryptophan catabolic process (GO:0006569)3.51617186
51DNA packaging (GO:0006323)3.51001537
52piRNA metabolic process (GO:0034587)3.49468981
53folic acid-containing compound biosynthetic process (GO:0009396)3.48486552
54motile cilium assembly (GO:0044458)3.46900891
55RNA destabilization (GO:0050779)3.43257099
56regulation of Rab GTPase activity (GO:0032313)3.42704738
57positive regulation of Rab GTPase activity (GO:0032851)3.42704738
58microtubule severing (GO:0051013)3.39270810
59chromosome condensation (GO:0030261)3.39093670
60indolalkylamine metabolic process (GO:0006586)3.38493148
61formation of translation preinitiation complex (GO:0001731)3.36839052
62single fertilization (GO:0007338)3.33277709
63tryptophan metabolic process (GO:0006568)3.32058347
64cell wall macromolecule metabolic process (GO:0044036)3.32054168
65histone H4-K12 acetylation (GO:0043983)3.26232561
66DNA strand elongation involved in DNA replication (GO:0006271)3.25584805
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.25327354
68regulation of translation, ncRNA-mediated (GO:0045974)3.25327354
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25327354
70DNA methylation involved in gamete generation (GO:0043046)3.25117583
71regulation of centriole replication (GO:0046599)3.24417613
72cell wall macromolecule catabolic process (GO:0016998)3.24184789
73cornea development in camera-type eye (GO:0061303)3.23688732
74coenzyme catabolic process (GO:0009109)3.19141828
75DNA strand elongation (GO:0022616)3.18248774
76male meiosis (GO:0007140)3.14382248
77DNA double-strand break processing (GO:0000729)3.14286856
78regulation of translational fidelity (GO:0006450)3.11956412
79cilium organization (GO:0044782)3.11177843
80intra-S DNA damage checkpoint (GO:0031573)3.09581729
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.08188586
82telomere maintenance via semi-conservative replication (GO:0032201)3.07961188
83organic cation transport (GO:0015695)3.07810354
84limb bud formation (GO:0060174)3.07564882
85positive regulation of protein homooligomerization (GO:0032464)3.05838942
86cilium assembly (GO:0042384)3.05358854
87spinal cord motor neuron differentiation (GO:0021522)3.04918482
88negative regulation of Rho protein signal transduction (GO:0035024)3.04113145
89germ cell development (GO:0007281)3.02442322
90regulation of microtubule-based movement (GO:0060632)3.01862067
91kynurenine metabolic process (GO:0070189)2.97957819
92ribosomal small subunit assembly (GO:0000028)2.97800205
93tRNA methylation (GO:0030488)2.95267449
94mitotic nuclear envelope disassembly (GO:0007077)2.91554895
95peptidyl-threonine dephosphorylation (GO:0035970)2.86960443
96fertilization (GO:0009566)2.85727752
97proline biosynthetic process (GO:0006561)2.85001418
98acrosome assembly (GO:0001675)2.84881354
99regulation of action potential (GO:0098900)2.83371159
100male meiosis I (GO:0007141)2.82584831
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80799883
102microtubule nucleation (GO:0007020)2.80505413
103protein localization to kinetochore (GO:0034501)2.79980672
104L-fucose catabolic process (GO:0042355)2.78581347
105fucose catabolic process (GO:0019317)2.78581347
106L-fucose metabolic process (GO:0042354)2.78581347
107replication fork processing (GO:0031297)2.77776603
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77624796
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77624796
110regulation of transcription involved in cell fate commitment (GO:0060850)2.76260979
111amine catabolic process (GO:0009310)2.74630272
112cellular biogenic amine catabolic process (GO:0042402)2.74630272
113cilium morphogenesis (GO:0060271)2.73790745
114photoreceptor cell maintenance (GO:0045494)2.73565939
115multicellular organismal reproductive process (GO:0048609)2.73193123
116nucleobase biosynthetic process (GO:0046112)2.72709532
117pteridine-containing compound biosynthetic process (GO:0042559)2.72603646
118protein localization to cilium (GO:0061512)2.72026697
119maturation of SSU-rRNA (GO:0030490)2.71700371
120NAD biosynthetic process (GO:0009435)2.70217957
121cellular process involved in reproduction in multicellular organism (GO:0022412)2.69956348
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69820612
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.69820612
124ribosome biogenesis (GO:0042254)2.67815596
125protein-DNA complex disassembly (GO:0032986)2.67586054
126nucleosome disassembly (GO:0006337)2.67586054
127DNA unwinding involved in DNA replication (GO:0006268)2.66946917
128histone mRNA catabolic process (GO:0071044)2.66147750
129DNA replication initiation (GO:0006270)2.65983674
130nuclear envelope disassembly (GO:0051081)2.65331807
131membrane disassembly (GO:0030397)2.65331807
132mRNA cleavage (GO:0006379)2.65237129
133ventricular system development (GO:0021591)2.65053451
134pseudouridine synthesis (GO:0001522)2.64294515
135spliceosomal snRNP assembly (GO:0000387)2.64134089
136viral transcription (GO:0019083)2.63492774
137telomere maintenance via recombination (GO:0000722)2.62413985
138protein K6-linked ubiquitination (GO:0085020)2.62041835
139kinetochore assembly (GO:0051382)2.60981014
140trophectodermal cell differentiation (GO:0001829)2.60576562
141base-excision repair (GO:0006284)2.59735188
142mitotic metaphase plate congression (GO:0007080)2.59074544
143ribosomal large subunit biogenesis (GO:0042273)2.59015255
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.58864321
145protein localization to chromosome, centromeric region (GO:0071459)2.57983201
146sequestering of actin monomers (GO:0042989)2.57460843
147NIK/NF-kappaB signaling (GO:0038061)2.54408488
148COPI coating of Golgi vesicle (GO:0048205)2.53164062
149Golgi transport vesicle coating (GO:0048200)2.53164062
150regulation of posttranscriptional gene silencing (GO:0060147)2.52518956
151regulation of gene silencing by miRNA (GO:0060964)2.52518956
152regulation of gene silencing by RNA (GO:0060966)2.52518956
153translational termination (GO:0006415)2.52143983
154regulation of chromatin binding (GO:0035561)2.51613843
155negative regulation of RNA splicing (GO:0033119)2.51279530
156SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50933745
157IMP biosynthetic process (GO:0006188)2.50916002
158translational initiation (GO:0006413)2.50793024
159antigen processing and presentation of endogenous antigen (GO:0019883)2.50493289
160purine nucleobase biosynthetic process (GO:0009113)2.50396382
161negative regulation of histone methylation (GO:0031061)2.50389256
162positive regulation of gamma-delta T cell activation (GO:0046645)2.50003881
163V(D)J recombination (GO:0033151)2.48123028
164ribonucleoprotein complex biogenesis (GO:0022613)2.46330295
165deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46326700
166histone H4-K8 acetylation (GO:0043982)2.46272891
167histone H4-K5 acetylation (GO:0043981)2.46272891
168translational elongation (GO:0006414)2.45617077
169maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44669091
170regulation of histone H3-K9 methylation (GO:0051570)2.44367809
171telomere maintenance via telomere lengthening (GO:0010833)2.43889021
172spliceosomal tri-snRNP complex assembly (GO:0000244)2.43818767
173rRNA processing (GO:0006364)2.43306985
174heterochromatin organization (GO:0070828)2.42258709
175kinetochore organization (GO:0051383)2.42253386
176nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.41163143
177nuclear pore organization (GO:0006999)2.40221442
178negative regulation of erythrocyte differentiation (GO:0045647)2.39959738
179protein targeting to ER (GO:0045047)2.39819526
180rRNA metabolic process (GO:0016072)2.39798236
181DNA duplex unwinding (GO:0032508)2.38299759
182RNA splicing, via transesterification reactions (GO:0000375)2.38112624
183somatic diversification of immune receptors (GO:0002200)2.37907947
184mRNA splicing, via spliceosome (GO:0000398)2.37755711
185RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.37755711
186cotranslational protein targeting to membrane (GO:0006613)2.37196998
187regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.35156118
188negative regulation of meiosis (GO:0045835)2.35122536
189DNA geometric change (GO:0032392)2.34463159
190somatic cell DNA recombination (GO:0016444)2.34346084
191somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.34346084
192metaphase plate congression (GO:0051310)2.33975534
193termination of RNA polymerase II transcription (GO:0006369)2.33076270
194histone H2A monoubiquitination (GO:0035518)2.32988202
195histone arginine methylation (GO:0034969)2.32389569
196negative regulation of mRNA processing (GO:0050686)2.32049946
197DNA replication-dependent nucleosome assembly (GO:0006335)2.31795505
198DNA replication-dependent nucleosome organization (GO:0034723)2.31795505
199mitotic recombination (GO:0006312)2.31184426
200regulation of nuclear cell cycle DNA replication (GO:0033262)2.29380861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.66412348
2ZNF274_21170338_ChIP-Seq_K562_Hela3.84165232
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.19790746
4* MYC_22102868_ChIP-Seq_BL_Human3.01802840
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.01695893
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01513213
7EZH2_22144423_ChIP-Seq_EOC_Human2.75853499
8GBX2_23144817_ChIP-Seq_PC3_Human2.75160455
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.61143201
10VDR_22108803_ChIP-Seq_LS180_Human2.53108865
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51317949
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51067751
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.40717427
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36123623
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34966387
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.28232434
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26427122
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.26287121
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25195817
20FUS_26573619_Chip-Seq_HEK293_Human2.24648581
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22557312
22ER_23166858_ChIP-Seq_MCF-7_Human2.22167476
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20270270
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20201018
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17592313
26VDR_21846776_ChIP-Seq_THP-1_Human2.17540008
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.13133936
28CBP_20019798_ChIP-Seq_JUKART_Human2.13133936
29IGF1R_20145208_ChIP-Seq_DFB_Human2.08449616
30* ETS1_20019798_ChIP-Seq_JURKAT_Human2.07372131
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05555220
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.05555220
33P300_19829295_ChIP-Seq_ESCs_Human2.00694827
34* GABP_17652178_ChIP-ChIP_JURKAT_Human1.95823997
35* XRN2_22483619_ChIP-Seq_HELA_Human1.95178972
36* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93316701
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93143840
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91435090
39* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90632076
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.88701376
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87289646
42* VDR_23849224_ChIP-Seq_CD4+_Human1.86060947
43TAF15_26573619_Chip-Seq_HEK293_Human1.85192468
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85153685
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76362124
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73002348
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72690082
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71690363
49GABP_19822575_ChIP-Seq_HepG2_Human1.70861737
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69158438
51CIITA_25753668_ChIP-Seq_RAJI_Human1.68293625
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67682172
53FOXP3_21729870_ChIP-Seq_TREG_Human1.66584667
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65296207
55EWS_26573619_Chip-Seq_HEK293_Human1.61463821
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60934009
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59786132
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.59395247
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59220200
60* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57058847
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56605526
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56483888
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56226418
64NANOG_20526341_ChIP-Seq_ESCs_Human1.55053082
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54982933
66AR_25329375_ChIP-Seq_VCAP_Human1.54377008
67ERA_21632823_ChIP-Seq_H3396_Human1.53134973
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52575437
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52475557
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50563614
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49916691
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49503073
73STAT3_23295773_ChIP-Seq_U87_Human1.49261294
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.47590591
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47103073
76TFEB_21752829_ChIP-Seq_HELA_Human1.45883775
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44328112
78* TTF2_22483619_ChIP-Seq_HELA_Human1.44242603
79* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43991903
80* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42327114
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.42136625
82MYC_19829295_ChIP-Seq_ESCs_Human1.42092514
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.42016586
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41350883
85MAF_26560356_Chip-Seq_TH1_Human1.40903843
86* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40558197
87* DCP1A_22483619_ChIP-Seq_HELA_Human1.40308579
88SMAD4_21799915_ChIP-Seq_A2780_Human1.39979491
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.39558101
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39484773
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39403136
92WDR5_24793694_ChIP-Seq_LNCAP_Human1.39064702
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37898824
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.36746962
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36550265
96KDM5A_27292631_Chip-Seq_BREAST_Human1.36257552
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35826552
98UTX_26944678_Chip-Seq_JUKART_Human1.35796978
99NANOG_19829295_ChIP-Seq_ESCs_Human1.35615837
100SOX2_19829295_ChIP-Seq_ESCs_Human1.35615837
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35530967
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35399857
103IRF1_19129219_ChIP-ChIP_H3396_Human1.35347166
104TCF7_22412390_ChIP-Seq_EML_Mouse1.34263847
105* E2F1_21310950_ChIP-Seq_MCF-7_Human1.33128815
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33012668
107RUNX2_22187159_ChIP-Seq_PCA_Human1.32901370
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32705649
109AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32588783
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32223147
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31435591
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.30885948
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30265725
114TP53_22573176_ChIP-Seq_HFKS_Human1.29555549
115* SPI1_23547873_ChIP-Seq_NB4_Human1.29304744
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28738445
117OCT4_20526341_ChIP-Seq_ESCs_Human1.27845562
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27808543
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27677428
120RAC3_21632823_ChIP-Seq_H3396_Human1.27118010
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25200513
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23989664
123TAF2_19829295_ChIP-Seq_ESCs_Human1.23550878
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23514240
125TCF4_23295773_ChIP-Seq_U87_Human1.23512083
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.23310180
127* REST_21632747_ChIP-Seq_MESCs_Mouse1.22482042
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.22148429
129HOXB7_26014856_ChIP-Seq_BT474_Human1.21587247
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21023899
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20996549
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19733908
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19290718
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18955066
135NCOR_22424771_ChIP-Seq_293T_Human1.18868718
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18449608
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18022655
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17556786
139MYB_26560356_Chip-Seq_TH2_Human1.17060811
140TP63_19390658_ChIP-ChIP_HaCaT_Human1.16568679
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.16268352
142AR_21572438_ChIP-Seq_LNCaP_Human1.15778466
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14880177
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14568312
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14139045
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12181591
147* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11813520
148SMAD3_21741376_ChIP-Seq_ESCs_Human1.11365188
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10761994
150MYB_26560356_Chip-Seq_TH1_Human1.10398411
151KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10231318
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10174527
153TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10145095
154MAF_26560356_Chip-Seq_TH2_Human1.09786679
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09542178
156RUNX1_22412390_ChIP-Seq_EML_Mouse1.09383471
157* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09190428
158* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09190428
159HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08923265
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07555002
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06611195
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06292532
163ETV1_20927104_ChIP-Seq_GIST48_Human1.04952266
164SCL_19346495_ChIP-Seq_HPC-7_Human1.04126989
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03856661
166GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03324567
167* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03054254
168BCAT_22108803_ChIP-Seq_LS180_Human1.03036411
169KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03028783
170KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03028783
171KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03028783
172CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02665468
173TBL1_22424771_ChIP-Seq_293T_Human1.02402822
174TCF4_22108803_ChIP-Seq_LS180_Human1.02234389
175FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02082779
176PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01736859
177SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01535849
178SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01336469
179SRF_21415370_ChIP-Seq_HL-1_Mouse1.00945735
180KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00478430
181KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00181843
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00034505
183VDR_24763502_ChIP-Seq_THP-1_Human0.99865978
184FLI1_21867929_ChIP-Seq_TH2_Mouse0.99817390
185GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99800509
186ELK3_25401928_ChIP-Seq_HUVEC_Human0.99390067
187RXR_22108803_ChIP-Seq_LS180_Human0.99103346
188OCT1_27270436_Chip-Seq_PROSTATE_Human0.98247923
189* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97950508
190RBPJ_21746931_ChIP-Seq_IB4_Human0.97037770
191SMRT_27268052_Chip-Seq_Bcells_Human0.96846154
192CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96568876
193MYC_18940864_ChIP-ChIP_HL60_Human0.94990711
194* DROSHA_22980978_ChIP-Seq_HELA_Human0.94674684
195* ERG_20517297_ChIP-Seq_VCAP_Human0.93495187
196PHF8_20622853_ChIP-Seq_HELA_Human0.93461243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.32366694
2MP0003878_abnormal_ear_physiology4.40878192
3MP0005377_hearing/vestibular/ear_phenot4.40878192
4MP0003693_abnormal_embryo_hatching4.29347663
5MP0008057_abnormal_DNA_replication3.03511097
6MP0010094_abnormal_chromosome_stability2.81343778
7MP0003111_abnormal_nucleus_morphology2.78037624
8MP0003698_abnormal_male_reproductive2.74537806
9MP0004957_abnormal_blastocyst_morpholog2.65376312
10MP0003077_abnormal_cell_cycle2.62219401
11MP0008058_abnormal_DNA_repair2.56814412
12MP0001485_abnormal_pinna_reflex2.56441735
13MP0003646_muscle_fatigue2.49403475
14MP0008007_abnormal_cellular_replicative2.27127586
15MP0003763_abnormal_thymus_physiology2.25044722
16MP0005670_abnormal_white_adipose2.24122778
17MP0005551_abnormal_eye_electrophysiolog2.23691350
18MP0009278_abnormal_bone_marrow2.11469477
19MP0001968_abnormal_touch/_nociception2.04452893
20MP0010352_gastrointestinal_tract_polyps2.02095717
21MP0000490_abnormal_crypts_of2.00335260
22MP0002653_abnormal_ependyma_morphology1.94743703
23MP0002396_abnormal_hematopoietic_system1.89766486
24MP0000569_abnormal_digit_pigmentation1.87325552
25MP0009333_abnormal_splenocyte_physiolog1.86314731
26MP0000685_abnormal_immune_system1.85449195
27MP0002837_dystrophic_cardiac_calcinosis1.85278938
28MP0001486_abnormal_startle_reflex1.84463683
29MP0003136_yellow_coat_color1.83765149
30MP0002398_abnormal_bone_marrow1.80256431
31MP0003718_maternal_effect1.78617941
32MP0002877_abnormal_melanocyte_morpholog1.75336785
33MP0001835_abnormal_antigen_presentation1.75275610
34MP0001800_abnormal_humoral_immune1.73635057
35MP0008877_abnormal_DNA_methylation1.71100725
36MP0005397_hematopoietic_system_phenotyp1.68584382
37MP0001545_abnormal_hematopoietic_system1.68584382
38MP0005253_abnormal_eye_physiology1.67115392
39MP0001730_embryonic_growth_arrest1.64879666
40MP0002735_abnormal_chemical_nociception1.62593008
41MP0000350_abnormal_cell_proliferation1.61914815
42MP0002822_catalepsy1.60042204
43MP0001986_abnormal_taste_sensitivity1.59348040
44MP0000689_abnormal_spleen_morphology1.58522470
45MP0000703_abnormal_thymus_morphology1.57444796
46MP0009046_muscle_twitch1.55813081
47MP0006292_abnormal_olfactory_placode1.55060743
48MP0002102_abnormal_ear_morphology1.54568952
49MP0006054_spinal_hemorrhage1.52455358
50MP0004808_abnormal_hematopoietic_stem1.52303093
51MP0003436_decreased_susceptibility_to1.51468933
52MP0002160_abnormal_reproductive_system1.49588482
53MP0005671_abnormal_response_to1.49451559
54MP0002722_abnormal_immune_system1.49093659
55MP0001790_abnormal_immune_system1.46625159
56MP0005387_immune_system_phenotype1.46625159
57MP0003195_calcinosis1.46370183
58MP0005257_abnormal_intraocular_pressure1.44075702
59MP0009840_abnormal_foam_cell1.42922156
60MP0001697_abnormal_embryo_size1.42615513
61MP0005367_renal/urinary_system_phenotyp1.41850136
62MP0000516_abnormal_urinary_system1.41850136
63MP0005084_abnormal_gallbladder_morpholo1.41289367
64MP0005174_abnormal_tail_pigmentation1.40998387
65MP0002723_abnormal_immune_serum1.40585588
66MP0005075_abnormal_melanosome_morpholog1.40315623
67MP0002452_abnormal_antigen_presenting1.39526478
68MP0009745_abnormal_behavioral_response1.39346920
69MP0000313_abnormal_cell_death1.39333868
70MP0003787_abnormal_imprinting1.38869541
71MP0002693_abnormal_pancreas_physiology1.38336957
72MP0000716_abnormal_immune_system1.37964213
73MP0006072_abnormal_retinal_apoptosis1.37488524
74MP0002163_abnormal_gland_morphology1.36226986
75MP0002420_abnormal_adaptive_immunity1.36111750
76MP0002429_abnormal_blood_cell1.35038148
77MP0004742_abnormal_vestibular_system1.34726159
78MP0010307_abnormal_tumor_latency1.34048045
79MP0001819_abnormal_immune_cell1.33643827
80MP0002405_respiratory_system_inflammati1.33637500
81MP0002161_abnormal_fertility/fecundity1.33435443
82MP0001984_abnormal_olfaction1.33145601
83MP0002019_abnormal_tumor_incidence1.33000984
84MP0010030_abnormal_orbit_morphology1.31903945
85MP0005000_abnormal_immune_tolerance1.31490387
86MP0008932_abnormal_embryonic_tissue1.31040605
87MP0005646_abnormal_pituitary_gland1.30889783
88MP0005380_embryogenesis_phenotype1.28742697
89MP0001672_abnormal_embryogenesis/_devel1.28742697
90MP0002254_reproductive_system_inflammat1.25678740
91MP0002080_prenatal_lethality1.23116772
92MP0005310_abnormal_salivary_gland1.22594425
93MP0005076_abnormal_cell_differentiation1.22472243
94MP0003984_embryonic_growth_retardation1.21843035
95MP0002088_abnormal_embryonic_growth/wei1.21315486
96MP0000427_abnormal_hair_cycle1.19873970
97MP0003011_delayed_dark_adaptation1.18860217
98MP0000653_abnormal_sex_gland1.17825940
99MP0001919_abnormal_reproductive_system1.16773136
100MP0002086_abnormal_extraembryonic_tissu1.16144421
101MP0001944_abnormal_pancreas_morphology1.16015009
102MP0001963_abnormal_hearing_physiology1.15389217
103MP0002736_abnormal_nociception_after1.14633428
104MP0002272_abnormal_nervous_system1.14546926
105MP0002638_abnormal_pupillary_reflex1.14439307
106MP0001529_abnormal_vocalization1.13827366
107MP0001501_abnormal_sleep_pattern1.13228203
108MP0002067_abnormal_sensory_capabilities1.13065564
109MP0002085_abnormal_embryonic_tissue1.12956325
110MP0003123_paternal_imprinting1.12433245
111MP0003786_premature_aging1.12018992
112MP0002084_abnormal_developmental_patter1.11466851
113MP0000026_abnormal_inner_ear1.09360979
114MP0003119_abnormal_digestive_system1.09089702
115MP0010155_abnormal_intestine_physiology1.08880412
116MP0005389_reproductive_system_phenotype1.08761289
117MP0002229_neurodegeneration1.08560711
118MP0000678_abnormal_parathyroid_gland1.08230009
119MP0002928_abnormal_bile_duct1.07645827
120MP0002009_preneoplasia1.06767439
121MP0008875_abnormal_xenobiotic_pharmacok1.06078172
122MP0003866_abnormal_defecation1.05051588
123MP0008789_abnormal_olfactory_epithelium1.05038597
124MP0005220_abnormal_exocrine_pancreas1.03300353
125MP0003303_peritoneal_inflammation1.02757116
126MP0002557_abnormal_social/conspecific_i1.01422606
127MP0002210_abnormal_sex_determination1.01298737
128MP0003890_abnormal_embryonic-extraembry0.99915243
129MP0005379_endocrine/exocrine_gland_phen0.99759113
130MP0001929_abnormal_gametogenesis0.99703902
131MP0010386_abnormal_urinary_bladder0.99074336
132MP0001915_intracranial_hemorrhage0.98272039
133MP0003566_abnormal_cell_adhesion0.98199296
134MP0002166_altered_tumor_susceptibility0.97725402
135MP0005083_abnormal_biliary_tract0.96891414
136MP0002572_abnormal_emotion/affect_behav0.96776965
137MP0005025_abnormal_response_to0.96288111
138MP0005167_abnormal_blood-brain_barrier0.95682158
139MP0004043_abnormal_pH_regulation0.95314152
140MP0001905_abnormal_dopamine_level0.94139191
141MP0004197_abnormal_fetal_growth/weight/0.93398317
142MP0004142_abnormal_muscle_tone0.91463453
143MP0001293_anophthalmia0.91420666
144MP0001145_abnormal_male_reproductive0.91245124
145MP0002064_seizures0.90864559
146MP0000631_abnormal_neuroendocrine_gland0.90732544
147MP0002751_abnormal_autonomic_nervous0.90337567
148MP0002089_abnormal_postnatal_growth/wei0.89487346
149MP0002234_abnormal_pharynx_morphology0.89158160
150MP0003137_abnormal_impulse_conducting0.88641455
151MP0004215_abnormal_myocardial_fiber0.88076671
152MP0005423_abnormal_somatic_nervous0.87725979
153MP0001970_abnormal_pain_threshold0.87657668
154MP0000858_altered_metastatic_potential0.86805275
155MP0003567_abnormal_fetal_cardiomyocyte0.85541901
156MP0002733_abnormal_thermal_nociception0.85042931
157MP0005386_behavior/neurological_phenoty0.84966102
158MP0004924_abnormal_behavior0.84966102
159MP0006276_abnormal_autonomic_nervous0.84745145
160MP0002277_abnormal_respiratory_mucosa0.84622512
161MP0001324_abnormal_eye_pigmentation0.83852193
162MP0009764_decreased_sensitivity_to0.83363030
163MP0002148_abnormal_hypersensitivity_rea0.83199990
164MP0005645_abnormal_hypothalamus_physiol0.83139990
165MP0005394_taste/olfaction_phenotype0.81687205
166MP0005499_abnormal_olfactory_system0.81687205
167MP0004133_heterotaxia0.79271622
168MP0008872_abnormal_physiological_respon0.78974884
169MP0005195_abnormal_posterior_eye0.77851920
170MP0001765_abnormal_ion_homeostasis0.77615557
171MP0002752_abnormal_somatic_nervous0.77080767
172MP0002138_abnormal_hepatobiliary_system0.76912782
173MP0003880_abnormal_central_pattern0.76859028
174MP0006082_CNS_inflammation0.76781752
175MP0002876_abnormal_thyroid_physiology0.76612420
176MP0002132_abnormal_respiratory_system0.74955802
177MP0001845_abnormal_inflammatory_respons0.74500261
178MP0000015_abnormal_ear_pigmentation0.74464365
179MP0001873_stomach_inflammation0.74067632
180MP0002419_abnormal_innate_immunity0.73852001
181MP0004484_altered_response_of0.73787080
182MP0002282_abnormal_trachea_morphology0.73442797
183MP0003943_abnormal_hepatobiliary_system0.72874667
184MP0005248_abnormal_Harderian_gland0.72526351
185MP0000778_abnormal_nervous_system0.71008984
186MP0000538_abnormal_urinary_bladder0.70679367

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.74044831
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.34684188
3Absent/shortened dynein arms (HP:0200106)4.34684188
4Attenuation of retinal blood vessels (HP:0007843)4.23106184
5Severe visual impairment (HP:0001141)3.98395338
6Nephronophthisis (HP:0000090)3.86906605
7Tubulointerstitial nephritis (HP:0001970)3.84931416
8Pancreatic cysts (HP:0001737)3.62960795
9Bony spicule pigmentary retinopathy (HP:0007737)3.53518678
10Abnormal ciliary motility (HP:0012262)3.52578834
11Abnormal respiratory motile cilium morphology (HP:0005938)3.44806335
12Abnormal respiratory epithelium morphology (HP:0012253)3.44806335
13Abnormal rod and cone electroretinograms (HP:0008323)3.43122686
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.43043097
15Pancreatic fibrosis (HP:0100732)3.34552090
16Molar tooth sign on MRI (HP:0002419)3.31956692
17Abnormality of midbrain morphology (HP:0002418)3.31956692
18Abnormality of the renal medulla (HP:0100957)3.31296278
19True hermaphroditism (HP:0010459)3.28944848
20Congenital stationary night blindness (HP:0007642)3.24779507
21Nasal polyposis (HP:0100582)3.14792905
22IgM deficiency (HP:0002850)3.04586478
23Abnormal respiratory motile cilium physiology (HP:0012261)2.99269457
24Hyperventilation (HP:0002883)2.88822532
25Pendular nystagmus (HP:0012043)2.86953652
26Type II lissencephaly (HP:0007260)2.86940582
27Intestinal atresia (HP:0011100)2.86697936
28Tubular atrophy (HP:0000092)2.86427156
29Abnormality of T cell physiology (HP:0011840)2.81195743
30Elevated erythrocyte sedimentation rate (HP:0003565)2.79879317
31Abnormality of the pancreatic islet cells (HP:0006476)2.75770634
32Abnormality of endocrine pancreas physiology (HP:0012093)2.75770634
33Abnormality of macular pigmentation (HP:0008002)2.75002921
34Abnormality of the nasal mucosa (HP:0000433)2.74481560
35Reticulocytopenia (HP:0001896)2.73126832
36Progressive cerebellar ataxia (HP:0002073)2.71434144
37Agnosia (HP:0010524)2.70888085
38Absent thumb (HP:0009777)2.67433009
39Abnormality of the renal cortex (HP:0011035)2.62474510
40Inability to walk (HP:0002540)2.61338838
41Ependymoma (HP:0002888)2.57475434
42Panhypogammaglobulinemia (HP:0003139)2.57164628
43Protruding tongue (HP:0010808)2.55743248
44Polydipsia (HP:0001959)2.52223718
45Abnormal drinking behavior (HP:0030082)2.52223718
46Recurrent viral infections (HP:0004429)2.50266287
47Abnormality of T cells (HP:0002843)2.50093025
48Degeneration of anterior horn cells (HP:0002398)2.49850624
49Abnormality of the anterior horn cell (HP:0006802)2.49850624
50Recurrent bronchitis (HP:0002837)2.48715635
51Thrombocytosis (HP:0001894)2.47920527
52Basal cell carcinoma (HP:0002671)2.45521701
53Decreased central vision (HP:0007663)2.44970628
54Absent speech (HP:0001344)2.42420301
55Tubulointerstitial abnormality (HP:0001969)2.41418917
56Congenital hepatic fibrosis (HP:0002612)2.38022646
57Gastrointestinal inflammation (HP:0004386)2.37844072
58Personality changes (HP:0000751)2.36135563
59Retinal dysplasia (HP:0007973)2.35550165
60Sclerocornea (HP:0000647)2.33772984
61Abnormality of the ileum (HP:0001549)2.31791234
62Selective tooth agenesis (HP:0001592)2.30398571
63Patellar aplasia (HP:0006443)2.29184545
64Cystic liver disease (HP:0006706)2.28112406
65Colitis (HP:0002583)2.27210186
66Myelodysplasia (HP:0002863)2.26255240
67Rough bone trabeculation (HP:0100670)2.25390025
68Abnormality of cells of the erythroid lineage (HP:0012130)2.25285204
69Bronchitis (HP:0012387)2.24199303
70Medulloblastoma (HP:0002885)2.22091886
71Cerebellar dysplasia (HP:0007033)2.22084270
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.21650870
73Medial flaring of the eyebrow (HP:0010747)2.21102548
74Recurrent fungal infections (HP:0002841)2.20639168
7511 pairs of ribs (HP:0000878)2.20189064
76Inflammation of the large intestine (HP:0002037)2.17711032
77Lymphoma (HP:0002665)2.17283615
78Abnormal number of erythroid precursors (HP:0012131)2.16503786
79Optic nerve hypoplasia (HP:0000609)2.15877793
80Anencephaly (HP:0002323)2.15361329
81Polyuria (HP:0000103)2.15082612
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14878244
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13994835
84Chromsome breakage (HP:0040012)2.13622603
85Clumsiness (HP:0002312)2.13326074
86Aplasia/Hypoplasia of the patella (HP:0006498)2.13320567
87Aplastic anemia (HP:0001915)2.12258139
88Lissencephaly (HP:0001339)2.11591907
89Pancreatic islet-cell hyperplasia (HP:0004510)2.09834628
90B lymphocytopenia (HP:0010976)2.09691436
91Abnormality of B cell number (HP:0010975)2.09691436
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09171115
93Gaze-evoked nystagmus (HP:0000640)2.08187493
94Large for gestational age (HP:0001520)2.08051842
95Hyperkalemia (HP:0002153)2.07669677
96Abnormality of T cell number (HP:0011839)2.07393330
97Broad alveolar ridges (HP:0000187)2.07226673
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.06928161
99Prominent metopic ridge (HP:0005487)2.04845702
100Infertility (HP:0000789)2.04211137
101Azoospermia (HP:0000027)2.03286986
102Amaurosis fugax (HP:0100576)2.03174031
103Late onset (HP:0003584)2.01929753
104Ketosis (HP:0001946)2.01784657
105Neoplasm of the adrenal cortex (HP:0100641)2.00632514
106T lymphocytopenia (HP:0005403)1.99018931
107Abnormality of the labia minora (HP:0012880)1.98422682
108Meckel diverticulum (HP:0002245)1.97486356
109Carpal bone hypoplasia (HP:0001498)1.97182466
110Cellular immunodeficiency (HP:0005374)1.95955014
111Vaginal fistula (HP:0004320)1.95514763
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95281120
113Hypoglycemic seizures (HP:0002173)1.94541996
114Chronic otitis media (HP:0000389)1.94292675
115Abnormal urine output (HP:0012590)1.94049190
116Rectal fistula (HP:0100590)1.93921400
117Rectovaginal fistula (HP:0000143)1.93921400
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93861578
119Congenital sensorineural hearing impairment (HP:0008527)1.93792620
120Overlapping toe (HP:0001845)1.92475762
121Microretrognathia (HP:0000308)1.92000321
122Facial hemangioma (HP:0000329)1.91953384
123Bone marrow hypocellularity (HP:0005528)1.91126587
124Impulsivity (HP:0100710)1.90688710
125Intestinal fistula (HP:0100819)1.90603337
126Progressive muscle weakness (HP:0003323)1.90386446
127Hypochromic anemia (HP:0001931)1.90078123
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89630381
129Birth length less than 3rd percentile (HP:0003561)1.89457401
130Dysostosis multiplex (HP:0000943)1.89263797
131Obstructive lung disease (HP:0006536)1.89231939
132Chronic obstructive pulmonary disease (HP:0006510)1.89231939
133Sloping forehead (HP:0000340)1.89080101
134Premature ovarian failure (HP:0008209)1.88906724
135Bulbous nose (HP:0000414)1.88571857
136Abnormality of chromosome stability (HP:0003220)1.87826967
137Broad-based gait (HP:0002136)1.87630402
138Chronic bronchitis (HP:0004469)1.87424804
139Stage 5 chronic kidney disease (HP:0003774)1.87359197
140Premature graying of hair (HP:0002216)1.87232592
141Hypoalbuminemia (HP:0003073)1.86228300
142Abnormal albumin level (HP:0012116)1.86228300
143Male pseudohermaphroditism (HP:0000037)1.86113287
144Gait imbalance (HP:0002141)1.86032012
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.85423322
146Prominent nose (HP:0000448)1.85355504
147Macular degeneration (HP:0000608)1.83814146
148Symptomatic seizures (HP:0011145)1.82743400
149Abnormal spermatogenesis (HP:0008669)1.82178688
150Hand muscle atrophy (HP:0009130)1.82080153
151Neoplasm of the pancreas (HP:0002894)1.81857433
152Photophobia (HP:0000613)1.81466392
153Abolished electroretinogram (ERG) (HP:0000550)1.80771706
154Cerebral hypomyelination (HP:0006808)1.80377287
155Interstitial pulmonary disease (HP:0006530)1.80200780
156Abnormal number of incisors (HP:0011064)1.79923298
157Supernumerary spleens (HP:0009799)1.79910256
158Abnormality of DNA repair (HP:0003254)1.79898311
159Rhinitis (HP:0012384)1.79116234
160Congenital primary aphakia (HP:0007707)1.77534673
161Rib fusion (HP:0000902)1.76923986
162Global brain atrophy (HP:0002283)1.76284555
163Occipital encephalocele (HP:0002085)1.76266552
164Abnormality of the preputium (HP:0100587)1.76221492
165Acute lymphatic leukemia (HP:0006721)1.76048419
166Type II diabetes mellitus (HP:0005978)1.75868918
167Poikiloderma (HP:0001029)1.75582669
168Recurrent sinusitis (HP:0011108)1.75508059
169Type I transferrin isoform profile (HP:0003642)1.74675099
170Prolonged QT interval (HP:0001657)1.74379360
171Leukopenia (HP:0001882)1.74366362
172Enlarged epiphyses (HP:0010580)1.73058984
173Tongue fasciculations (HP:0001308)1.73041038
174Cone-rod dystrophy (HP:0000548)1.72821161
175Bronchiectasis (HP:0002110)1.72352353
176Astigmatism (HP:0000483)1.71526396
177Small hand (HP:0200055)1.71209505
178Recurrent abscess formation (HP:0002722)1.71199128
179Median cleft lip (HP:0000161)1.71005778
180Albinism (HP:0001022)1.70781395
181Pustule (HP:0200039)1.70358995
182Hepatoblastoma (HP:0002884)1.70188434
183Pachygyria (HP:0001302)1.68840211
184Progressive inability to walk (HP:0002505)1.68457143
185Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67545036
186Drooling (HP:0002307)1.65393087
187Genetic anticipation (HP:0003743)1.64154783
188Clubbing of toes (HP:0100760)1.64014179
189Poor coordination (HP:0002370)1.63386240
190Aplasia/Hypoplasia of the tongue (HP:0010295)1.63108781
191Thyroiditis (HP:0100646)1.62123427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48475226
2PASK4.67282280
3PINK14.42992851
4MAP4K23.84832369
5MAP4K13.10842318
6MAP3K103.00603666
7NEK22.64078294
8WNK32.61699172
9TLK12.59954847
10ADRBK22.59854529
11DYRK32.18276068
12BMPR1B2.01893450
13PNCK1.99957111
14CAMK1D1.98154347
15ZAK1.97065500
16FLT31.96946856
17BUB11.96267599
18CAMK1G1.93871261
19ERN11.93691808
20EEF2K1.92522908
21INSRR1.91974816
22MAPK151.91674204
23CDK121.86067298
24TRIB31.86022976
25PLK21.74861495
26ICK1.74433173
27TNIK1.73172493
28CDC71.70587038
29GRK11.65650047
30BLK1.63463337
31WNK41.61715879
32ZAP701.60924910
33MARK11.59190370
34WEE11.56614015
35SCYL21.56051401
36JAK31.47818561
37STK38L1.47167583
38MAPK131.45229736
39RPS6KA41.45042391
40CDK71.40409690
41MAP3K111.37181256
42PIM11.35575122
43TESK21.34410345
44GRK61.33503265
45TESK11.29179062
46EPHA21.26804084
47TBK11.25969300
48ATR1.25311493
49MAP2K71.25086055
50HIPK21.24690469
51TRIM281.23053698
52PIM21.19632112
53BTK1.18648162
54STK101.18061784
55PLK41.17968745
56CDK41.17791489
57PLK11.17474695
58CAMKK21.14286078
59CSNK1A1L1.14094134
60ACVR1B1.12524116
61CSNK1G31.11295762
62CSNK1G11.10188875
63TGFBR21.10153091
64NUAK11.10006542
65PTK2B1.08957891
66CASK1.08071371
67RPS6KB21.07422506
68CSNK1G21.05160905
69TXK1.04146477
70DYRK21.03955045
71MAP3K61.02545936
72TSSK61.01762263
73IRAK31.01103215
74EIF2AK31.00515102
75STK381.00339254
76DYRK1B1.00302991
77MAP3K40.98902685
78CHEK20.97708079
79CDK80.97521838
80KDR0.94843298
81PAK40.94193686
82CCNB10.93221963
83TGFBR10.88798906
84TYK20.87590921
85NME20.86832899
86CHUK0.86804454
87MAP2K30.86673314
88DDR20.85784098
89IKBKB0.85204179
90PRKD20.84531325
91SRPK10.84077095
92CSF1R0.83631298
93TTK0.80023723
94CSK0.79546389
95MARK30.79175422
96CHEK10.78732333
97PKN20.76341269
98PIK3CG0.76324712
99MAPKAPK30.75765442
100IRAK40.74479996
101DAPK10.73946682
102PAK30.73868341
103MKNK20.72101490
104MAP2K20.71979919
105FGFR20.71566955
106OBSCN0.71278962
107OXSR10.71060021
108AURKB0.70392617
109SYK0.69201942
110MAP3K80.67533959
111TNK20.65680147
112VRK10.65350451
113PRKCG0.64969101
114TEC0.64718435
115MAP3K140.64200063
116WNK10.63472698
117YES10.62966148
118MAPK110.62051866
119TIE10.61707372
120NLK0.60575134
121SGK2230.59086985
122SGK4940.59086985
123CDK20.58787658
124MUSK0.58473656
125STK40.57773656
126ADRBK10.57727410
127BRD40.57223874
128BRSK20.57017141
129SIK20.56658120
130PRKCE0.56643518
131TAOK30.56604060
132SGK20.55668143
133MTOR0.55068393
134PKN10.54421947
135PHKG20.53600395
136PHKG10.53600395
137ERBB30.53219462
138RPS6KA50.52688304
139AURKA0.51397661
140LCK0.51138170
141CAMK10.50862521
142BCKDK0.50814711
143PRKAA20.50065136
144LYN0.49958006
145PRKCQ0.49632516
146MAPKAPK20.49603944
147STK390.49335443
148PRKCI0.49084033
149CDK30.48831104
150RPS6KC10.48188854
151RPS6KL10.48188854
152UHMK10.47468965
153CDK60.47261145
154ALK0.46899103
155PRKD30.46872059
156PRKG10.45674581
157TYRO30.44229394
158CAMK40.43814977
159RPS6KA60.43143168
160AKT30.42840286
161CSNK1D0.40327665
162PDK10.38989087
163ATM0.38912223
164CSNK1A10.37473558
165STK110.37150874
166PRKCZ0.34267714
167NTRK30.32154454
168PRKAA10.30831027
169PDPK10.30521438
170PRKACA0.30496659
171MAPK80.28377389
172GSK3B0.26502106
173RPS6KA10.25141469
174STK160.24566672

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.85100456
2Butanoate metabolism_Homo sapiens_hsa006503.37617640
3DNA replication_Homo sapiens_hsa030303.34361431
4Mismatch repair_Homo sapiens_hsa034303.08234430
5Base excision repair_Homo sapiens_hsa034102.91830213
6Phototransduction_Homo sapiens_hsa047442.77459143
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77001920
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73466229
9Spliceosome_Homo sapiens_hsa030402.67780975
10Fatty acid biosynthesis_Homo sapiens_hsa000612.60011961
11Olfactory transduction_Homo sapiens_hsa047402.50006358
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35951013
13RNA transport_Homo sapiens_hsa030132.34942307
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.24715756
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24044400
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13705192
17Homologous recombination_Homo sapiens_hsa034402.08661992
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08285937
19One carbon pool by folate_Homo sapiens_hsa006702.00428337
20Ribosome_Homo sapiens_hsa030101.97800171
21Nicotine addiction_Homo sapiens_hsa050331.88628055
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88321822
23Nucleotide excision repair_Homo sapiens_hsa034201.84503506
24Cell cycle_Homo sapiens_hsa041101.82969583
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77964438
26RNA polymerase_Homo sapiens_hsa030201.77502985
27Tryptophan metabolism_Homo sapiens_hsa003801.74917114
28Fanconi anemia pathway_Homo sapiens_hsa034601.74277327
29Taste transduction_Homo sapiens_hsa047421.70933586
30Primary immunodeficiency_Homo sapiens_hsa053401.70003021
31Sulfur relay system_Homo sapiens_hsa041221.66763640
32Nitrogen metabolism_Homo sapiens_hsa009101.65886767
33mRNA surveillance pathway_Homo sapiens_hsa030151.60453379
34Proteasome_Homo sapiens_hsa030501.59930110
35Pyrimidine metabolism_Homo sapiens_hsa002401.55671178
36Antigen processing and presentation_Homo sapiens_hsa046121.55241335
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47893604
38p53 signaling pathway_Homo sapiens_hsa041151.47745840
39Dorso-ventral axis formation_Homo sapiens_hsa043201.45333031
40Non-homologous end-joining_Homo sapiens_hsa034501.43526711
41Herpes simplex infection_Homo sapiens_hsa051681.40972845
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36778464
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34535188
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33249459
45ABC transporters_Homo sapiens_hsa020101.31691271
46Epstein-Barr virus infection_Homo sapiens_hsa051691.30188617
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.29530699
48Propanoate metabolism_Homo sapiens_hsa006401.28554235
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28204731
50Basal transcription factors_Homo sapiens_hsa030221.27198901
51Linoleic acid metabolism_Homo sapiens_hsa005911.25822633
52RNA degradation_Homo sapiens_hsa030181.25333430
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24925079
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23993832
55B cell receptor signaling pathway_Homo sapiens_hsa046621.23880098
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21665947
57Acute myeloid leukemia_Homo sapiens_hsa052211.19734063
58Viral carcinogenesis_Homo sapiens_hsa052031.19689482
59Selenocompound metabolism_Homo sapiens_hsa004501.17621989
60Folate biosynthesis_Homo sapiens_hsa007901.16951928
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.12694819
62Morphine addiction_Homo sapiens_hsa050321.12137487
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11303052
64Hedgehog signaling pathway_Homo sapiens_hsa043401.10277212
65Measles_Homo sapiens_hsa051621.08692230
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.07330772
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05386547
68Legionellosis_Homo sapiens_hsa051341.04888144
69Notch signaling pathway_Homo sapiens_hsa043301.04678675
70Systemic lupus erythematosus_Homo sapiens_hsa053221.02690294
71Apoptosis_Homo sapiens_hsa042101.02659224
72Protein export_Homo sapiens_hsa030601.01030555
73HTLV-I infection_Homo sapiens_hsa051660.99329505
74Peroxisome_Homo sapiens_hsa041460.98078686
75Chronic myeloid leukemia_Homo sapiens_hsa052200.95996138
76Circadian entrainment_Homo sapiens_hsa047130.95430805
77Other glycan degradation_Homo sapiens_hsa005110.95346265
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94531853
79Calcium signaling pathway_Homo sapiens_hsa040200.92286069
80Caffeine metabolism_Homo sapiens_hsa002320.91936916
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90849062
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84396355
83Small cell lung cancer_Homo sapiens_hsa052220.83118017
84Colorectal cancer_Homo sapiens_hsa052100.82834810
85Ether lipid metabolism_Homo sapiens_hsa005650.82383818
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81785035
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.81780156
88mTOR signaling pathway_Homo sapiens_hsa041500.81233864
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.81169383
90Insulin secretion_Homo sapiens_hsa049110.80254184
91Galactose metabolism_Homo sapiens_hsa000520.79269361
92Type II diabetes mellitus_Homo sapiens_hsa049300.76852477
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75598405
94Osteoclast differentiation_Homo sapiens_hsa043800.74103299
95Fatty acid degradation_Homo sapiens_hsa000710.74068301
96Purine metabolism_Homo sapiens_hsa002300.74028037
97Fructose and mannose metabolism_Homo sapiens_hsa000510.73942452
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73649178
99Shigellosis_Homo sapiens_hsa051310.73420390
100Type I diabetes mellitus_Homo sapiens_hsa049400.73313647
101T cell receptor signaling pathway_Homo sapiens_hsa046600.72624111
102Hepatitis B_Homo sapiens_hsa051610.72233241
103Leishmaniasis_Homo sapiens_hsa051400.71688370
104GABAergic synapse_Homo sapiens_hsa047270.71152274
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.70112959
106Glutamatergic synapse_Homo sapiens_hsa047240.69687462
107Fatty acid metabolism_Homo sapiens_hsa012120.69066696
108Salivary secretion_Homo sapiens_hsa049700.68957199
109Influenza A_Homo sapiens_hsa051640.66628570
110Thyroid cancer_Homo sapiens_hsa052160.65832529
111Glycerolipid metabolism_Homo sapiens_hsa005610.64044700
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63888362
113Chemical carcinogenesis_Homo sapiens_hsa052040.63110420
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.61450471
115Serotonergic synapse_Homo sapiens_hsa047260.59902194
116Steroid biosynthesis_Homo sapiens_hsa001000.58818216
117Prolactin signaling pathway_Homo sapiens_hsa049170.56368038
118TNF signaling pathway_Homo sapiens_hsa046680.56180867
119N-Glycan biosynthesis_Homo sapiens_hsa005100.55927499
120Hematopoietic cell lineage_Homo sapiens_hsa046400.55248495
121Pentose phosphate pathway_Homo sapiens_hsa000300.54425963
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.54042404
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52954173
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52885376
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51642361
126Ovarian steroidogenesis_Homo sapiens_hsa049130.50952918
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50429646
128beta-Alanine metabolism_Homo sapiens_hsa004100.50098540
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49921621
130Toxoplasmosis_Homo sapiens_hsa051450.49551786
131Circadian rhythm_Homo sapiens_hsa047100.49286379
132HIF-1 signaling pathway_Homo sapiens_hsa040660.48621100
133Metabolic pathways_Homo sapiens_hsa011000.48579952
134Regulation of autophagy_Homo sapiens_hsa041400.48568751
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48439472
136cAMP signaling pathway_Homo sapiens_hsa040240.47718900
137Basal cell carcinoma_Homo sapiens_hsa052170.46660899
138Pancreatic cancer_Homo sapiens_hsa052120.46638832
139Lysine degradation_Homo sapiens_hsa003100.45077812
140MicroRNAs in cancer_Homo sapiens_hsa052060.44722815
141Alcoholism_Homo sapiens_hsa050340.44458599
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44340640
143Retinol metabolism_Homo sapiens_hsa008300.44035722
144Non-small cell lung cancer_Homo sapiens_hsa052230.43641481
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43609098
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43459814
147Bladder cancer_Homo sapiens_hsa052190.42059242
148FoxO signaling pathway_Homo sapiens_hsa040680.41333247
149Cholinergic synapse_Homo sapiens_hsa047250.41306728
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40970528
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40035652
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39499413
153Sphingolipid metabolism_Homo sapiens_hsa006000.38724245
154Prostate cancer_Homo sapiens_hsa052150.38461242
155Cocaine addiction_Homo sapiens_hsa050300.38343178
156Lysosome_Homo sapiens_hsa041420.38274808
157Oocyte meiosis_Homo sapiens_hsa041140.38110025
158Graft-versus-host disease_Homo sapiens_hsa053320.37157530
159Allograft rejection_Homo sapiens_hsa053300.35545086
160Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34387641
161Oxytocin signaling pathway_Homo sapiens_hsa049210.33646063
162Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33543788
163Huntingtons disease_Homo sapiens_hsa050160.32299304
164Pathways in cancer_Homo sapiens_hsa052000.29814426
165Dopaminergic synapse_Homo sapiens_hsa047280.29274418
166Adipocytokine signaling pathway_Homo sapiens_hsa049200.23912159
167Renin secretion_Homo sapiens_hsa049240.23400762
168MAPK signaling pathway_Homo sapiens_hsa040100.22021824

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