ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.41973947
2	proteasome assembly (GO:0043248)	4.83116817
3	rRNA methylation (GO:0031167)	4.55084345
4	rRNA modification (GO:0000154)	4.54117270
5	piRNA metabolic process (GO:0034587)	4.04510698
6	DNA deamination (GO:0045006)	4.01183738
7	peptidyl-histidine modification (GO:0018202)	3.87080057
8	DNA double-strand break processing (GO:0000729)	3.80652911
9	poly(A)+ mRNA export from nucleus (GO:0016973)	3.79487732
10	regulation of meiosis I (GO:0060631)	3.78362652
11	cullin deneddylation (GO:0010388)	3.58602249
12	centriole replication (GO:0007099)	3.56268734
13	synapsis (GO:0007129)	3.42165688
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.38054033
15	sperm motility (GO:0030317)	3.37435797
16	protein deneddylation (GO:0000338)	3.35689491
17	protein complex biogenesis (GO:0070271)	3.32504830
18	resolution of meiotic recombination intermediates (GO:0000712)	3.32374456
19	platelet dense granule organization (GO:0060155)	3.23440388
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.15976819
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.15864208
22	protein neddylation (GO:0045116)	3.15456644
23	regulation of cilium movement (GO:0003352)	3.10987665
24	fusion of sperm to egg plasma membrane (GO:0007342)	3.08865892
25	fucose catabolic process (GO:0019317)	3.06402922
26	L-fucose metabolic process (GO:0042354)	3.06402922
27	L-fucose catabolic process (GO:0042355)	3.06402922
28	single strand break repair (GO:0000012)	3.06367000
29	respiratory chain complex IV assembly (GO:0008535)	3.06226170
30	acrosome reaction (GO:0007340)	3.05868268
31	mannosylation (GO:0097502)	3.05599698
32	spermatid nucleus differentiation (GO:0007289)	3.04444112
33	microtubule depolymerization (GO:0007019)	3.04095194
34	ubiquinone biosynthetic process (GO:0006744)	3.02251884
35	epithelial cilium movement (GO:0003351)	3.01911335
36	ubiquinone metabolic process (GO:0006743)	3.01048871
37	replication fork processing (GO:0031297)	2.96759109
38	cellular ketone body metabolic process (GO:0046950)	2.96108035
39	inositol phosphate catabolic process (GO:0071545)	2.92918166
40	lactate metabolic process (GO:0006089)	2.92658150
41	protein polyglutamylation (GO:0018095)	2.91913155
42	cytochrome complex assembly (GO:0017004)	2.89224772
43	sequestering of actin monomers (GO:0042989)	2.88584260
44	DNA methylation involved in gamete generation (GO:0043046)	2.88394067
45	male meiosis (GO:0007140)	2.87535728
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86752956
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86752956
48	NADH dehydrogenase complex assembly (GO:0010257)	2.86752956
49	ketone body metabolic process (GO:1902224)	2.84653816
50	male meiosis I (GO:0007141)	2.83495287
51	negative regulation of neurological system process (GO:0031645)	2.80138589
52	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.78980290
53	protein targeting to Golgi (GO:0000042)	2.78939371
54	protein localization to Golgi apparatus (GO:0034067)	2.76633179
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76286397
56	establishment of protein localization to Golgi (GO:0072600)	2.75676488
57	protein-cofactor linkage (GO:0018065)	2.74161027
58	histone H2A acetylation (GO:0043968)	2.73063649
59	regulation of hexokinase activity (GO:1903299)	2.72336440
60	regulation of glucokinase activity (GO:0033131)	2.72336440
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68100382
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68100382
63	DNA damage response, detection of DNA damage (GO:0042769)	2.66693786
64	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.64832507
65	inositol phosphate dephosphorylation (GO:0046855)	2.64832507
66	intraciliary transport (GO:0042073)	2.62897283
67	adenosine metabolic process (GO:0046085)	2.62371072
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59822873
69	positive regulation of meiosis (GO:0045836)	2.59577096
70	negative regulation by host of viral transcription (GO:0043922)	2.58394651
71	negative regulation of thymocyte apoptotic process (GO:0070244)	2.56061858
72	DNA catabolic process, exonucleolytic (GO:0000738)	2.54254676
73	sperm-egg recognition (GO:0035036)	2.53854151
74	protein K11-linked deubiquitination (GO:0035871)	2.52791610
75	cornea development in camera-type eye (GO:0061303)	2.51727651
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51183771
77	protein localization to cilium (GO:0061512)	2.49891495
78	spermatid development (GO:0007286)	2.47909409
79	axoneme assembly (GO:0035082)	2.47551902
80	plasma membrane fusion (GO:0045026)	2.47511154
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45735356
82	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45472841
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.45461282
84	termination of RNA polymerase III transcription (GO:0006386)	2.45461282
85	neural tube formation (GO:0001841)	2.45371396
86	histone mRNA metabolic process (GO:0008334)	2.45234676
87	multicellular organism reproduction (GO:0032504)	2.44193282
88	positive regulation of meiotic cell cycle (GO:0051446)	2.43283185
89	C-terminal protein lipidation (GO:0006501)	2.42700878
90	seminiferous tubule development (GO:0072520)	2.40171721
91	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.39177934
92	indolalkylamine metabolic process (GO:0006586)	2.38830919
93	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.38374607
94	positive regulation of glycolytic process (GO:0045821)	2.38086165
95	cilium morphogenesis (GO:0060271)	2.38001614
96	centriole assembly (GO:0098534)	2.37606761
97	regulation of male gonad development (GO:2000018)	2.36144550
98	quinone biosynthetic process (GO:1901663)	2.36143897
99	S-adenosylmethionine metabolic process (GO:0046500)	2.34793565
100	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.34597726

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45078617
2	VDR_22108803_ChIP-Seq_LS180_Human	3.31871850
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.96059094
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.89620903
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76683043
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.67767659
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67662131
8	FUS_26573619_Chip-Seq_HEK293_Human	2.60468047
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54836058
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.50807208
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.46895673
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.39360647
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36159612
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28022905
15	EWS_26573619_Chip-Seq_HEK293_Human	2.24271719
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20360676
17	P300_19829295_ChIP-Seq_ESCs_Human	2.11456662
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.09778019
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01728361
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97924461
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96144202
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92593090
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90124931
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.88356346
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82633357
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77791578
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76255160
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.72995556
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69365216
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63016826
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61611928
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.61611928
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60933359
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60418291
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56497445
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49733242
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.49160645
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48460876
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47121916
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.44289069
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43901928
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43901928
43	AR_25329375_ChIP-Seq_VCAP_Human	1.41954358
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38459334
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37431084
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36993535
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.36857007
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34259424
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33053621
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.32897355
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29971145
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29323877
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.29126836
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28695149
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28567677
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28155845
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28134850
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26543318
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.26432522
60	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26110037
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25572461
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25572461
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25157519
64	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22987310
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22963896
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22802127
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22662906
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22337548
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20392370
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.19957777
71	STAT3_23295773_ChIP-Seq_U87_Human	1.19880670
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19184700
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18929511
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18386643
75	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13830626
76	AR_20517297_ChIP-Seq_VCAP_Human	1.13712449
77	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13372333
78	P300_18555785_Chip-Seq_ESCs_Mouse	1.12674004
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12575375
80	TCF4_23295773_ChIP-Seq_U87_Human	1.11824382
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.11316593
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10952775
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08661910
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08525606
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08510891
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08429829
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07839021
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07600485
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06192109
90	NCOR_22424771_ChIP-Seq_293T_Human	1.04502522
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04312583
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04022235
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03723961
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03189112
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03179177
96	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03004331
97	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02797419
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02558868
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02558868
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02012170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.49832493
2	MP0002102_abnormal_ear_morphology	3.28639934
3	MP0006072_abnormal_retinal_apoptosis	3.20606136
4	MP0000372_irregular_coat_pigmentation	2.78365690
5	MP0005410_abnormal_fertilization	2.64326206
6	MP0001529_abnormal_vocalization	2.53322981
7	MP0003195_calcinosis	2.50957935
8	MP0005084_abnormal_gallbladder_morpholo	2.48423186
9	MP0008058_abnormal_DNA_repair	2.40911114
10	MP0002837_dystrophic_cardiac_calcinosis	2.40456142
11	MP0005253_abnormal_eye_physiology	2.27194252
12	MP0003880_abnormal_central_pattern	2.13905265
13	MP0001986_abnormal_taste_sensitivity	2.11777229
14	MP0003787_abnormal_imprinting	2.00087509
15	MP0009697_abnormal_copulation	1.97893824
16	MP0005551_abnormal_eye_electrophysiolog	1.93718942
17	MP0005646_abnormal_pituitary_gland	1.89701670
18	MP0005075_abnormal_melanosome_morpholog	1.78698517
19	MP0006292_abnormal_olfactory_placode	1.77861095
20	MP0005379_endocrine/exocrine_gland_phen	1.73080561
21	MP0002736_abnormal_nociception_after	1.69761442
22	MP0008995_early_reproductive_senescence	1.67610651
23	MP0003698_abnormal_male_reproductive	1.56614393
24	MP0001929_abnormal_gametogenesis	1.56452456
25	MP0001968_abnormal_touch/_nociception	1.56128246
26	MP0002822_catalepsy	1.54158949
27	MP0006054_spinal_hemorrhage	1.50923879
28	MP0001764_abnormal_homeostasis	1.49671886
29	MP0003718_maternal_effect	1.48897997
30	MP0008872_abnormal_physiological_respon	1.48769915
31	MP0002938_white_spotting	1.37575885
32	MP0002751_abnormal_autonomic_nervous	1.36949323
33	MP0005171_absent_coat_pigmentation	1.36048382
34	MP0003119_abnormal_digestive_system	1.31781771
35	MP0002234_abnormal_pharynx_morphology	1.31490735
36	MP0003136_yellow_coat_color	1.31267957
37	MP0004215_abnormal_myocardial_fiber	1.31009880
38	MP0003011_delayed_dark_adaptation	1.30035954
39	MP0010094_abnormal_chromosome_stability	1.28689026
40	MP0000631_abnormal_neuroendocrine_gland	1.25566677
41	MP0004133_heterotaxia	1.25385022
42	MP0000516_abnormal_urinary_system	1.23668659
43	MP0005367_renal/urinary_system_phenotyp	1.23668659
44	MP0002876_abnormal_thyroid_physiology	1.23583729
45	MP0002163_abnormal_gland_morphology	1.23135502
46	MP0005671_abnormal_response_to	1.22664580
47	MP0001984_abnormal_olfaction	1.22467002
48	MP0002735_abnormal_chemical_nociception	1.22431196
49	MP0002272_abnormal_nervous_system	1.22239104
50	MP0001486_abnormal_startle_reflex	1.21986195
51	MP0009745_abnormal_behavioral_response	1.20233521
52	MP0005645_abnormal_hypothalamus_physiol	1.19736972
53	MP0004885_abnormal_endolymph	1.18905183
54	MP0000427_abnormal_hair_cycle	1.15040966
55	MP0003121_genomic_imprinting	1.12885096
56	MP0002653_abnormal_ependyma_morphology	1.11033833
57	MP0006276_abnormal_autonomic_nervous	1.10540385
58	MP0002210_abnormal_sex_determination	1.06856422
59	MP0009046_muscle_twitch	1.03461035
60	MP0002095_abnormal_skin_pigmentation	1.02544125
61	MP0000653_abnormal_sex_gland	1.02503070
62	MP0004142_abnormal_muscle_tone	1.01469662
63	MP0003786_premature_aging	0.99991695
64	MP0001188_hyperpigmentation	0.98770070
65	MP0001145_abnormal_male_reproductive	0.98737484
66	MP0005389_reproductive_system_phenotype	0.97839816
67	MP0003943_abnormal_hepatobiliary_system	0.96309372
68	MP0000569_abnormal_digit_pigmentation	0.95494797
69	MP0005386_behavior/neurological_phenoty	0.95423718
70	MP0004924_abnormal_behavior	0.95423718
71	MP0008057_abnormal_DNA_replication	0.93459811
72	MP0002132_abnormal_respiratory_system	0.92215175
73	MP0001485_abnormal_pinna_reflex	0.91502912
74	MP0001501_abnormal_sleep_pattern	0.89556465
75	MP0006035_abnormal_mitochondrial_morpho	0.88144337
76	MP0005174_abnormal_tail_pigmentation	0.86058677
77	MP0001905_abnormal_dopamine_level	0.85859136
78	MP0002006_tumorigenesis	0.85649172
79	MP0005391_vision/eye_phenotype	0.83858204
80	MP0008789_abnormal_olfactory_epithelium	0.83816482
81	MP0010386_abnormal_urinary_bladder	0.80736831
82	MP0003283_abnormal_digestive_organ	0.80565942
83	MP0001293_anophthalmia	0.79787966
84	MP0002572_abnormal_emotion/affect_behav	0.78552755
85	MP0001119_abnormal_female_reproductive	0.78487167
86	MP0002733_abnormal_thermal_nociception	0.77114804
87	MP0002160_abnormal_reproductive_system	0.76750841
88	MP0002693_abnormal_pancreas_physiology	0.76729722
89	MP0004043_abnormal_pH_regulation	0.74786804
90	MP0002138_abnormal_hepatobiliary_system	0.73657703
91	MP0003646_muscle_fatigue	0.73294228
92	MP0003122_maternal_imprinting	0.73092448
93	MP0006036_abnormal_mitochondrial_physio	0.72972799
94	MP0002166_altered_tumor_susceptibility	0.72964012
95	MP0001919_abnormal_reproductive_system	0.72258208
96	MP0001970_abnormal_pain_threshold	0.71902283
97	MP0000230_abnormal_systemic_arterial	0.71747403
98	MP0000383_abnormal_hair_follicle	0.69857771
99	MP0002928_abnormal_bile_duct	0.69423318
100	MP0005195_abnormal_posterior_eye	0.69310985

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.32633526
2	Attenuation of retinal blood vessels (HP:0007843)	3.32486925
3	Pancreatic cysts (HP:0001737)	3.21048638
4	Abnormality of midbrain morphology (HP:0002418)	3.04546673
5	Molar tooth sign on MRI (HP:0002419)	3.04546673
6	Thyroiditis (HP:0100646)	3.00163599
7	Abnormal rod and cone electroretinograms (HP:0008323)	2.95953127
8	Nephronophthisis (HP:0000090)	2.92291063
9	Pancreatic fibrosis (HP:0100732)	2.91291226
10	Chronic hepatic failure (HP:0100626)	2.77194600
11	Severe combined immunodeficiency (HP:0004430)	2.68710736
12	Medial flaring of the eyebrow (HP:0010747)	2.68186273
13	Hypoproteinemia (HP:0003075)	2.66274266
14	Abolished electroretinogram (ERG) (HP:0000550)	2.66116637
15	Constricted visual fields (HP:0001133)	2.65848254
16	Mitochondrial inheritance (HP:0001427)	2.63295089
17	Pendular nystagmus (HP:0012043)	2.59570501
18	Increased CSF lactate (HP:0002490)	2.57646149
19	Acute necrotizing encephalopathy (HP:0006965)	2.54223030
20	Abnormality of the renal cortex (HP:0011035)	2.53456212
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51789049
22	Absent/shortened dynein arms (HP:0200106)	2.51789049
23	Congenital stationary night blindness (HP:0007642)	2.51368514
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51140249
25	Progressive macrocephaly (HP:0004481)	2.48330344
26	Methylmalonic acidemia (HP:0002912)	2.47933853
27	Abnormality of the renal medulla (HP:0100957)	2.47019160
28	B lymphocytopenia (HP:0010976)	2.43980669
29	Hypothermia (HP:0002045)	2.41517291
30	Congenital, generalized hypertrichosis (HP:0004540)	2.39583812
31	Retinal dysplasia (HP:0007973)	2.34391748
32	Optic disc pallor (HP:0000543)	2.34338074
33	Type II lissencephaly (HP:0007260)	2.31894893
34	Acute encephalopathy (HP:0006846)	2.31352936
35	Hepatocellular necrosis (HP:0001404)	2.30611886
36	Hepatic necrosis (HP:0002605)	2.28844179
37	Abnormality of B cell number (HP:0010975)	2.28441753
38	Renal cortical cysts (HP:0000803)	2.27536552
39	Stomatitis (HP:0010280)	2.27100106
40	Increased hepatocellular lipid droplets (HP:0006565)	2.22305756
41	3-Methylglutaconic aciduria (HP:0003535)	2.22119667
42	Decreased central vision (HP:0007663)	2.13545299
43	Polydipsia (HP:0001959)	2.12216361
44	Abnormal drinking behavior (HP:0030082)	2.12216361
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.10744978
46	Abnormality of macular pigmentation (HP:0008002)	2.10483097
47	Panhypogammaglobulinemia (HP:0003139)	2.09766281
48	Combined immunodeficiency (HP:0005387)	2.08839013
49	Lipid accumulation in hepatocytes (HP:0006561)	2.08670419
50	Congenital primary aphakia (HP:0007707)	2.07112304
51	Colon cancer (HP:0003003)	2.04052169
52	Cerebellar dysplasia (HP:0007033)	2.03160080
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.01681299
54	IgG deficiency (HP:0004315)	2.01189982
55	Renal Fanconi syndrome (HP:0001994)	1.98146720
56	Gait imbalance (HP:0002141)	1.96780776
57	Intestinal atresia (HP:0011100)	1.95579423
58	Increased serum lactate (HP:0002151)	1.93511337
59	Methylmalonic aciduria (HP:0012120)	1.92488635
60	Abnormality of the labia minora (HP:0012880)	1.92276133
61	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89676144
62	Abnormal respiratory epithelium morphology (HP:0012253)	1.89073804
63	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89073804
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88012082
65	Congenital hepatic fibrosis (HP:0002612)	1.87204500
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86970409
67	Hypoplasia of the thymus (HP:0000778)	1.86090273
68	Gaze-evoked nystagmus (HP:0000640)	1.85721000
69	Nephrogenic diabetes insipidus (HP:0009806)	1.85421672
70	Short tibia (HP:0005736)	1.85078880
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84754159
72	Genital tract atresia (HP:0001827)	1.84317324
73	Ketoacidosis (HP:0001993)	1.81601008
74	Sclerocornea (HP:0000647)	1.81494048
75	Male pseudohermaphroditism (HP:0000037)	1.80410980
76	Abnormality of vitamin B metabolism (HP:0004340)	1.79950393
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77341599
78	Progressive inability to walk (HP:0002505)	1.76626611
79	Inability to walk (HP:0002540)	1.73848303
80	Polyuria (HP:0000103)	1.72632377
81	Abnormal ciliary motility (HP:0012262)	1.72631987
82	Hypoplasia of the fovea (HP:0007750)	1.72449348
83	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72449348
84	Abnormality of the fovea (HP:0000493)	1.71431198
85	Gonadotropin excess (HP:0000837)	1.68981508
86	Vaginal atresia (HP:0000148)	1.68819287
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.67060988
88	Congenital sensorineural hearing impairment (HP:0008527)	1.64961095
89	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.64765942
90	Gonadal dysgenesis (HP:0000133)	1.63374791
91	Large for gestational age (HP:0001520)	1.63316962
92	Thyroid-stimulating hormone excess (HP:0002925)	1.63098452
93	Postaxial foot polydactyly (HP:0001830)	1.62165178
94	Dyschromatopsia (HP:0007641)	1.61951250
95	Hypoplasia of the uterus (HP:0000013)	1.61516222
96	Tubular atrophy (HP:0000092)	1.61223069
97	Stomach cancer (HP:0012126)	1.61036081
98	Lactic acidosis (HP:0003128)	1.60929562
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.60754362
100	Sloping forehead (HP:0000340)	1.59872718

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.14998061
2	MAP4K2	3.83176199
3	ZAK	2.87701450
4	TRIM28	2.50311871
5	INSRR	2.25532228
6	TXK	2.23344760
7	EIF2AK3	2.16380302
8	WNK3	2.09185793
9	NUAK1	1.93501353
10	SRPK1	1.84534253
11	VRK2	1.81356224
12	ADRBK2	1.80580878
13	BCR	1.78634325
14	PLK4	1.77068664
15	VRK1	1.75766351
16	MKNK1	1.73575168
17	BRSK2	1.72421676
18	BMPR1B	1.68292963
19	PLK3	1.67064240
20	CSNK1G1	1.64044570
21	ERBB3	1.56769657
22	TSSK6	1.54801187
23	CSNK1G3	1.54078259
24	MST4	1.52414198
25	PLK2	1.49806016
26	PNCK	1.40223388
27	MAP3K4	1.39942132
28	MKNK2	1.37263009
29	CCNB1	1.36929868
30	CSNK1G2	1.35627101
31	STK16	1.27678743
32	STK38L	1.23749026
33	DYRK3	1.22879769
34	RPS6KA4	1.22563304
35	GRK1	1.21098246
36	ACVR1B	1.16780265
37	MAPK13	1.15670313
38	CSNK1A1L	1.13960348
39	TNIK	1.09610452
40	PINK1	1.09589135
41	TEC	1.06652393
42	TLK1	1.06271311
43	AKT3	1.01548072
44	PAK3	0.98563220
45	OXSR1	0.98528635
46	MAP2K7	0.97323148
47	STK39	0.93556323
48	PRKCE	0.93555599
49	WEE1	0.93489576
50	KIT	0.84249189
51	PASK	0.83412779
52	DYRK2	0.83384603
53	PBK	0.79903391
54	TAOK3	0.78422483
55	FER	0.73646537
56	WNK4	0.71793965
57	PDK2	0.71692479
58	EIF2AK1	0.70831913
59	PTK2B	0.69969710
60	CAMKK2	0.69075006
61	TGFBR1	0.64081469
62	MAP2K6	0.63293401
63	PRKCG	0.58318549
64	NLK	0.58116499
65	TAF1	0.57756496
66	EPHA4	0.56823205
67	PLK1	0.55317470
68	RPS6KA5	0.55146508
69	FGFR2	0.54400748
70	MINK1	0.52357284
71	CDK3	0.50970023
72	TRPM7	0.50038124
73	NEK1	0.49451797
74	TTK	0.49138835
75	PIK3CG	0.47208519
76	ADRBK1	0.45219051
77	SIK3	0.45115181
78	ATR	0.44919319
79	CAMK2A	0.44103775
80	TIE1	0.42037958
81	PRKCQ	0.39781190
82	TNK2	0.39225197
83	MUSK	0.39123722
84	CSNK1A1	0.38024244
85	CSNK1D	0.37671608
86	SGK2	0.36911149
87	NEK6	0.36734794
88	ITK	0.36638479
89	GRK7	0.36367150
90	EIF2AK2	0.35771438
91	ATM	0.35559288
92	IKBKB	0.35321162
93	PRKD3	0.34470734
94	PRKACA	0.33502677
95	MAPKAPK5	0.32048665
96	CSNK2A1	0.31617977
97	CDK19	0.31578769
98	PRKG1	0.30722315
99	FLT3	0.30625782
100	CASK	0.30590456

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.20662678
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.16999925
3	Proteasome_Homo sapiens_hsa03050	2.91437101
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.60976912
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57518901
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51752738
7	RNA polymerase_Homo sapiens_hsa03020	2.42434070
8	Butanoate metabolism_Homo sapiens_hsa00650	2.40902595
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.26890696
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17086914
11	Propanoate metabolism_Homo sapiens_hsa00640	2.11900391
12	Basal transcription factors_Homo sapiens_hsa03022	1.95011940
13	Parkinsons disease_Homo sapiens_hsa05012	1.94159263
14	Phototransduction_Homo sapiens_hsa04744	1.93737704
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.92566133
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.82947557
17	Homologous recombination_Homo sapiens_hsa03440	1.81332149
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72874060
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71903262
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69336565
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69237439
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69172615
23	RNA transport_Homo sapiens_hsa03013	1.57835907
24	RNA degradation_Homo sapiens_hsa03018	1.57704643
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.57049736
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55647654
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.51063991
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44751885
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.37444879
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36940738
31	Fatty acid elongation_Homo sapiens_hsa00062	1.33817040
32	Purine metabolism_Homo sapiens_hsa00230	1.33274543
33	Sulfur metabolism_Homo sapiens_hsa00920	1.26819924
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22765208
35	Huntingtons disease_Homo sapiens_hsa05016	1.22555321
36	Olfactory transduction_Homo sapiens_hsa04740	1.20928314
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.16060661
38	Nicotine addiction_Homo sapiens_hsa05033	1.14892377
39	Peroxisome_Homo sapiens_hsa04146	1.12562652
40	Spliceosome_Homo sapiens_hsa03040	1.12122684
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.10279890
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09322953
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.05630500
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.02817075
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.02194684
46	Regulation of autophagy_Homo sapiens_hsa04140	1.01615487
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00938940
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00914015
49	Mismatch repair_Homo sapiens_hsa03430	1.00514161
50	Taste transduction_Homo sapiens_hsa04742	0.99530339
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94007653
52	Alzheimers disease_Homo sapiens_hsa05010	0.93224811
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88926627
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87923433
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86691835
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85044212
57	Base excision repair_Homo sapiens_hsa03410	0.81957303
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79686233
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78826203
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.78822885
61	Metabolic pathways_Homo sapiens_hsa01100	0.71575794
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70913670
63	GABAergic synapse_Homo sapiens_hsa04727	0.70406767
64	Oocyte meiosis_Homo sapiens_hsa04114	0.67045680
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63789414
66	Retinol metabolism_Homo sapiens_hsa00830	0.63696976
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63048814
68	Morphine addiction_Homo sapiens_hsa05032	0.62969786
69	Serotonergic synapse_Homo sapiens_hsa04726	0.60602320
70	Circadian entrainment_Homo sapiens_hsa04713	0.58536816
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58316883
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56370713
73	One carbon pool by folate_Homo sapiens_hsa00670	0.55538443
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54500893
75	Caffeine metabolism_Homo sapiens_hsa00232	0.54242657
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.51346569
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50543158
78	Fatty acid degradation_Homo sapiens_hsa00071	0.49129654
79	Salivary secretion_Homo sapiens_hsa04970	0.48683600
80	Circadian rhythm_Homo sapiens_hsa04710	0.47880918
81	Folate biosynthesis_Homo sapiens_hsa00790	0.47447517
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.47410665
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.46948576
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46496720
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45767870
86	Insulin secretion_Homo sapiens_hsa04911	0.44642983
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.42869519
88	Allograft rejection_Homo sapiens_hsa05330	0.42831639
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40408244
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39540737
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37858124
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36926745
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35419671
94	Glutathione metabolism_Homo sapiens_hsa00480	0.33887154
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33081213
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.30257482
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.30235807
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.30172977
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30115810
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29628426

ZC3H11B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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