ZC3H12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.70343888
2vocalization behavior (GO:0071625)5.42871251
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38279591
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20302698
5regulation of glutamate receptor signaling pathway (GO:1900449)5.18447812
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.09480593
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.09038070
8neuron cell-cell adhesion (GO:0007158)4.94495810
9synaptic vesicle exocytosis (GO:0016079)4.93613059
10protein localization to synapse (GO:0035418)4.85789258
11glutamate receptor signaling pathway (GO:0007215)4.79363425
12synaptic transmission, glutamatergic (GO:0035249)4.69158002
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.64463075
14locomotory exploration behavior (GO:0035641)4.59037123
15presynaptic membrane assembly (GO:0097105)4.58168863
16glutamate secretion (GO:0014047)4.57716846
17neuron-neuron synaptic transmission (GO:0007270)4.45609791
18synaptic vesicle endocytosis (GO:0048488)4.34726975
19neuronal action potential propagation (GO:0019227)4.33354000
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.30849726
21regulation of synaptic vesicle exocytosis (GO:2000300)4.29891247
22neurotransmitter-gated ion channel clustering (GO:0072578)4.20670031
23regulation of synaptic vesicle transport (GO:1902803)4.11687480
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11329967
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.10517274
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.05891230
27long-term synaptic potentiation (GO:0060291)4.03575711
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03285283
29postsynaptic membrane organization (GO:0001941)4.02395654
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.01160259
31presynaptic membrane organization (GO:0097090)4.00812143
32regulation of neuronal synaptic plasticity (GO:0048168)3.97565638
33exploration behavior (GO:0035640)3.95219354
34regulation of postsynaptic membrane potential (GO:0060078)3.86445696
35synaptic vesicle maturation (GO:0016188)3.83995442
36long-term memory (GO:0007616)3.83229851
37startle response (GO:0001964)3.80267797
38regulation of synaptic transmission, glutamatergic (GO:0051966)3.77246667
39neurotransmitter secretion (GO:0007269)3.76887457
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73823182
41neuron recognition (GO:0008038)3.73058960
42positive regulation of synapse maturation (GO:0090129)3.69747548
43response to histamine (GO:0034776)3.69627551
44response to pheromone (GO:0019236)3.67235456
45regulation of meiosis I (GO:0060631)3.66719655
46epithelial cilium movement (GO:0003351)3.64850577
47regulation of synaptic plasticity (GO:0048167)3.61372500
48positive regulation of membrane potential (GO:0045838)3.61253686
49protein K11-linked deubiquitination (GO:0035871)3.59552194
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54071498
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54057602
52axonal fasciculation (GO:0007413)3.50229986
53regulation of synapse maturation (GO:0090128)3.49795123
54cerebellar Purkinje cell differentiation (GO:0021702)3.46602506
55behavioral response to nicotine (GO:0035095)3.45587454
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41690839
57behavioral fear response (GO:0001662)3.41437274
58behavioral defense response (GO:0002209)3.41437274
59L-fucose metabolic process (GO:0042354)3.40681015
60L-fucose catabolic process (GO:0042355)3.40681015
61fucose catabolic process (GO:0019317)3.40681015
62cerebellar granule cell differentiation (GO:0021707)3.39797360
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39785806
64regulation of neurotransmitter secretion (GO:0046928)3.37053959
65centriole replication (GO:0007099)3.33979053
66regulation of dendritic spine morphogenesis (GO:0061001)3.32535346
67gamma-aminobutyric acid transport (GO:0015812)3.30571076
68positive regulation of neurotransmitter secretion (GO:0001956)3.29392015
69cerebral cortex radially oriented cell migration (GO:0021799)3.28228090
70fear response (GO:0042596)3.27021657
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26409509
72regulation of synapse structural plasticity (GO:0051823)3.26371257
73regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.25978527
74dendritic spine morphogenesis (GO:0060997)3.23768368
75learning (GO:0007612)3.21958952
76negative regulation of dendrite development (GO:2000171)3.19764594
77membrane depolarization (GO:0051899)3.15035013
78negative regulation of dendrite morphogenesis (GO:0050774)3.14470299
79regulation of synaptic transmission, GABAergic (GO:0032228)3.14435339
80DNA methylation involved in gamete generation (GO:0043046)3.14191073
81piRNA metabolic process (GO:0034587)3.13782224
82axoneme assembly (GO:0035082)3.12415886
83neurotransmitter transport (GO:0006836)3.12178554
84detection of calcium ion (GO:0005513)3.12167770
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09544802
86glycerophospholipid catabolic process (GO:0046475)3.09544065
87regulation of respiratory system process (GO:0044065)3.07276615
88respiratory chain complex IV assembly (GO:0008535)3.07160310
89positive regulation of synaptic transmission (GO:0050806)3.06869342
90negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06725805
91transmission of nerve impulse (GO:0019226)3.06652695
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05772481
93positive regulation of synapse assembly (GO:0051965)3.05694754
94regulation of vesicle fusion (GO:0031338)3.05452095
95sphingoid metabolic process (GO:0046519)3.03455095
96synapse assembly (GO:0007416)3.03258969
97cilium movement (GO:0003341)3.02433584
98regulation of neurotransmitter transport (GO:0051588)3.02094098
99platelet dense granule organization (GO:0060155)3.01987716
100regulation of synaptic transmission (GO:0050804)3.01781594
101cochlea development (GO:0090102)3.00735259
102innervation (GO:0060384)2.99908314
103sphingosine metabolic process (GO:0006670)2.99739719
104regulation of dendritic spine development (GO:0060998)2.99471462
105positive regulation of neurotransmitter transport (GO:0051590)2.98603121
106response to auditory stimulus (GO:0010996)2.97695115
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.97144818
108detection of light stimulus involved in visual perception (GO:0050908)2.96797046
109detection of light stimulus involved in sensory perception (GO:0050962)2.96797046
110synaptic transmission (GO:0007268)2.94403966
111DNA double-strand break processing (GO:0000729)2.94371670
112cellular ketone body metabolic process (GO:0046950)2.94217789
113mechanosensory behavior (GO:0007638)2.92842166
114cilium morphogenesis (GO:0060271)2.92063032
115replication fork processing (GO:0031297)2.91219752
116water-soluble vitamin biosynthetic process (GO:0042364)2.90942147
117positive regulation of meiosis (GO:0045836)2.90298433
118diol metabolic process (GO:0034311)2.89297745
119protein polyglutamylation (GO:0018095)2.88579542
120protein localization to cilium (GO:0061512)2.87307612
121regulation of respiratory gaseous exchange (GO:0043576)2.86661821
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.85418073
123meiotic chromosome segregation (GO:0045132)2.85062281
124cellular potassium ion homeostasis (GO:0030007)2.84779767
125long term synaptic depression (GO:0060292)2.84431502
126regulation of cilium movement (GO:0003352)2.84023017
127auditory behavior (GO:0031223)2.83914953
128membrane depolarization during action potential (GO:0086010)2.83207007
129dendritic spine organization (GO:0097061)2.83031573
130regulation of neurotransmitter levels (GO:0001505)2.82382806
131intraciliary transport (GO:0042073)2.81622812
132membrane hyperpolarization (GO:0060081)2.81491451
133synaptic vesicle transport (GO:0048489)2.78931429
134establishment of synaptic vesicle localization (GO:0097480)2.78931429
135glycosphingolipid biosynthetic process (GO:0006688)2.78377203
136cilium organization (GO:0044782)2.77502099
137reciprocal DNA recombination (GO:0035825)2.77465995
138reciprocal meiotic recombination (GO:0007131)2.77465995
139behavioral response to cocaine (GO:0048148)2.77029264
140rhodopsin mediated signaling pathway (GO:0016056)2.75302346
141protein complex biogenesis (GO:0070271)2.74854142
142nonmotile primary cilium assembly (GO:0035058)2.73996723
143dopamine transport (GO:0015872)2.73053899
144regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72900697
145serotonin metabolic process (GO:0042428)2.72176042
146cilium assembly (GO:0042384)2.72083896
147indolalkylamine metabolic process (GO:0006586)2.71503783
148positive regulation of meiotic cell cycle (GO:0051446)2.69242524
149protein-chromophore linkage (GO:0018298)2.66880236
150serotonin receptor signaling pathway (GO:0007210)2.65560598
151adaptation of signaling pathway (GO:0023058)2.63530787
152photoreceptor cell maintenance (GO:0045494)2.62857712
153heme transport (GO:0015886)2.62854944
154proline transport (GO:0015824)2.61539333
155NADH dehydrogenase complex assembly (GO:0010257)2.58721007
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58721007
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.58721007
158reflex (GO:0060004)2.58595972
159cytochrome complex assembly (GO:0017004)2.57553178
160establishment of protein localization to Golgi (GO:0072600)2.57486881
161pyrimidine nucleobase catabolic process (GO:0006208)2.56958417
162ketone body metabolic process (GO:1902224)2.55076916
163tachykinin receptor signaling pathway (GO:0007217)2.51490864
164neuronal action potential (GO:0019228)2.50795376
165somite rostral/caudal axis specification (GO:0032525)2.50339118
166regulation of protein glycosylation (GO:0060049)2.49875257
167mitochondrial respiratory chain complex assembly (GO:0033108)2.49046639
168protein neddylation (GO:0045116)2.48882419
169double-strand break repair via homologous recombination (GO:0000724)2.47768707
170recombinational repair (GO:0000725)2.47533468
171neural tube formation (GO:0001841)2.46818473
172primary amino compound metabolic process (GO:1901160)2.46787001
173mannosylation (GO:0097502)2.46469995
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.44864389
175peptidyl-histidine modification (GO:0018202)2.43583305
176positive regulation of developmental pigmentation (GO:0048087)2.42059569
177cilium or flagellum-dependent cell motility (GO:0001539)2.38772281
178regulation of glucokinase activity (GO:0033131)2.38764650
179regulation of hexokinase activity (GO:1903299)2.38764650
180preassembly of GPI anchor in ER membrane (GO:0016254)2.37366293
181indole-containing compound catabolic process (GO:0042436)2.36951099
182indolalkylamine catabolic process (GO:0046218)2.36951099
183tryptophan catabolic process (GO:0006569)2.36951099
184nucleobase catabolic process (GO:0046113)2.36068187
185indole-containing compound metabolic process (GO:0042430)2.35048714
186limb bud formation (GO:0060174)2.34948750
187cornea development in camera-type eye (GO:0061303)2.34413411
188somatic hypermutation of immunoglobulin genes (GO:0016446)2.34255172
189somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34255172
190DNA deamination (GO:0045006)2.33334917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79589770
2GBX2_23144817_ChIP-Seq_PC3_Human4.42449478
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89049019
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84159092
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80916208
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51560407
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51316632
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41867403
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36154782
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36154782
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.33341951
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.32285310
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30049809
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27982875
15REST_21632747_ChIP-Seq_MESCs_Mouse2.27579123
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26526538
17TAF15_26573619_Chip-Seq_HEK293_Human2.19482815
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13318464
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12049725
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11700816
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04997411
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01142590
23DROSHA_22980978_ChIP-Seq_HELA_Human2.00036776
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99867942
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97203060
26AR_21572438_ChIP-Seq_LNCaP_Human1.97116186
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.96022402
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95145904
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94963010
30* P300_19829295_ChIP-Seq_ESCs_Human1.94369765
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.92387893
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.88329946
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.87128229
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.84198091
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.83064592
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80689836
37FUS_26573619_Chip-Seq_HEK293_Human1.79677973
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79076928
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78195241
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72642990
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.62476259
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59695566
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59563380
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59132974
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58530414
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.56806079
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.55635105
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55627795
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54833251
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54527772
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54421370
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54337386
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52557650
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51387622
55STAT3_23295773_ChIP-Seq_U87_Human1.50703178
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47724914
57AR_25329375_ChIP-Seq_VCAP_Human1.47688421
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47300406
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.47146825
60TP53_22573176_ChIP-Seq_HFKS_Human1.46717577
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44475875
62CBP_20019798_ChIP-Seq_JUKART_Human1.43955636
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43955636
64NANOG_19829295_ChIP-Seq_ESCs_Human1.43737299
65SOX2_19829295_ChIP-Seq_ESCs_Human1.43737299
66ER_23166858_ChIP-Seq_MCF-7_Human1.43526860
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41570109
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38478301
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38139758
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37300651
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37264042
72RNF2_27304074_Chip-Seq_NSC_Mouse1.36678288
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.36561263
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36146794
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.35729575
76TCF4_23295773_ChIP-Seq_U87_Human1.35041801
77TCF4_22108803_ChIP-Seq_LS180_Human1.34484258
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34306506
79IGF1R_20145208_ChIP-Seq_DFB_Human1.32539510
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.31820953
81EWS_26573619_Chip-Seq_HEK293_Human1.31531576
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.30770056
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29157818
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28479583
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.25392478
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24603162
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24589891
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24533766
89MYC_18940864_ChIP-ChIP_HL60_Human1.23760910
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.23129679
91VDR_22108803_ChIP-Seq_LS180_Human1.22444571
92TP53_16413492_ChIP-PET_HCT116_Human1.22308369
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.21964004
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21799265
95TP53_18474530_ChIP-ChIP_U2OS_Human1.21654447
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.21153401
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20155538
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20061073
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.19385392
100AHR_22903824_ChIP-Seq_MCF-7_Human1.19151641
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19067488
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.18902832
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18407880
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18407880
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.18348232
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18348232
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18065738
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.17601900
109AR_19668381_ChIP-Seq_PC3_Human1.17397962
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.16845922
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.16421039
112P53_22387025_ChIP-Seq_ESCs_Mouse1.15608279
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15471804
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15436848
115JUN_21703547_ChIP-Seq_K562_Human1.13390706
116ELK1_19687146_ChIP-ChIP_HELA_Human1.11094761
117ZNF274_21170338_ChIP-Seq_K562_Hela1.09946121
118IRF1_19129219_ChIP-ChIP_H3396_Human1.09935138
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.09331389
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08928537
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08321147
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07725443
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.06882119
124SOX9_26525672_Chip-Seq_HEART_Mouse1.06627653
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06448115
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06331096
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06075763
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06059476
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.05875946
130NCOR_22424771_ChIP-Seq_293T_Human1.05477877
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04976367
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04866088
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03484664
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03148843
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02260019
136CDX2_22108803_ChIP-Seq_LS180_Human1.01864589
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01433247
138BCAT_22108803_ChIP-Seq_LS180_Human1.00357815
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.99968230
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97538692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83215857
2MP0003880_abnormal_central_pattern5.06954023
3MP0003635_abnormal_synaptic_transmissio3.96861716
4MP0001968_abnormal_touch/_nociception3.33703952
5MP0009745_abnormal_behavioral_response3.32593754
6MP0002063_abnormal_learning/memory/cond3.30169199
7MP0004270_analgesia3.19113826
8MP0003136_yellow_coat_color3.00425451
9MP0002064_seizures2.99344377
10MP0002572_abnormal_emotion/affect_behav2.97154213
11MP0009046_muscle_twitch2.88707181
12MP0002653_abnormal_ependyma_morphology2.85362946
13MP0002736_abnormal_nociception_after2.80913641
14MP0005423_abnormal_somatic_nervous2.74411931
15MP0001486_abnormal_startle_reflex2.50320803
16MP0002272_abnormal_nervous_system2.47944837
17MP0003195_calcinosis2.45947807
18MP0002734_abnormal_mechanical_nocicepti2.37998392
19MP0002735_abnormal_chemical_nociception2.32790142
20MP0001188_hyperpigmentation2.29849282
21MP0003787_abnormal_imprinting2.24158247
22MP0005646_abnormal_pituitary_gland2.18520890
23MP0001501_abnormal_sleep_pattern2.16896346
24MP0002822_catalepsy2.02605308
25MP0001440_abnormal_grooming_behavior2.02319213
26MP0002067_abnormal_sensory_capabilities2.02286379
27MP0004147_increased_porphyrin_level2.01318876
28MP0002557_abnormal_social/conspecific_i1.90682024
29MP0000778_abnormal_nervous_system1.89624837
30MP0005386_behavior/neurological_phenoty1.87196101
31MP0004924_abnormal_behavior1.87196101
32MP0002938_white_spotting1.79596485
33MP0006292_abnormal_olfactory_placode1.79579667
34MP0009780_abnormal_chondrocyte_physiolo1.73911020
35MP0002733_abnormal_thermal_nociception1.72870173
36MP0002184_abnormal_innervation1.72758880
37MP0001984_abnormal_olfaction1.68703369
38MP0001970_abnormal_pain_threshold1.64301375
39MP0008569_lethality_at_weaning1.59508108
40MP0006276_abnormal_autonomic_nervous1.57983232
41MP0005645_abnormal_hypothalamus_physiol1.57180422
42MP0003890_abnormal_embryonic-extraembry1.55585920
43MP0003122_maternal_imprinting1.54260180
44MP0004811_abnormal_neuron_physiology1.52814415
45MP0001529_abnormal_vocalization1.51941337
46MP0003879_abnormal_hair_cell1.46301231
47MP0000427_abnormal_hair_cycle1.42919851
48MP0005174_abnormal_tail_pigmentation1.42668641
49MP0004043_abnormal_pH_regulation1.37059398
50MP0001502_abnormal_circadian_rhythm1.33379463
51MP0002160_abnormal_reproductive_system1.31931129
52MP0002882_abnormal_neuron_morphology1.27529219
53MP0002066_abnormal_motor_capabilities/c1.26137676
54MP0002876_abnormal_thyroid_physiology1.25443023
55MP0005171_absent_coat_pigmentation1.23945334
56MP0000955_abnormal_spinal_cord1.23561995
57MP0001905_abnormal_dopamine_level1.22279592
58MP0003646_muscle_fatigue1.19947365
59MP0008058_abnormal_DNA_repair1.18329978
60MP0004145_abnormal_muscle_electrophysio1.16810946
61MP0000372_irregular_coat_pigmentation1.16077871
62MP0005084_abnormal_gallbladder_morpholo1.15372659
63MP0002163_abnormal_gland_morphology1.15056642
64MP0003718_maternal_effect1.13900943
65MP0005409_darkened_coat_color1.13841149
66MP0002234_abnormal_pharynx_morphology1.12703872
67MP0000631_abnormal_neuroendocrine_gland1.12149576
68MP0005551_abnormal_eye_electrophysiolog1.10203627
69MP0008057_abnormal_DNA_replication1.09609411
70MP0004133_heterotaxia1.08537028
71MP0002102_abnormal_ear_morphology1.07399615
72MP0003633_abnormal_nervous_system1.07052496
73MP0002152_abnormal_brain_morphology1.06056748
74MP0004858_abnormal_nervous_system1.05160883
75MP0010386_abnormal_urinary_bladder1.04199838
76MP0001177_atelectasis1.03900803
77MP0004142_abnormal_muscle_tone0.99154959
78MP0001986_abnormal_taste_sensitivity0.99098071
79MP0004885_abnormal_endolymph0.98759797
80MP0005389_reproductive_system_phenotype0.98566619
81MP0001963_abnormal_hearing_physiology0.97083919
82MP0008875_abnormal_xenobiotic_pharmacok0.96844386
83MP0000569_abnormal_digit_pigmentation0.94646989
84MP0003631_nervous_system_phenotype0.93603895
85MP0005410_abnormal_fertilization0.92920732
86MP0003698_abnormal_male_reproductive0.92586968
87MP0002837_dystrophic_cardiac_calcinosis0.91983119
88MP0003121_genomic_imprinting0.91260310
89MP0005365_abnormal_bile_salt0.90473218
90MP0002909_abnormal_adrenal_gland0.89202517
91MP0005075_abnormal_melanosome_morpholog0.89187402
92MP0003137_abnormal_impulse_conducting0.88530738
93MP0004484_altered_response_of0.86762767
94MP0005220_abnormal_exocrine_pancreas0.86118494
95MP0002928_abnormal_bile_duct0.85612619
96MP0001929_abnormal_gametogenesis0.84316959
97MP0004742_abnormal_vestibular_system0.83306004
98MP0003011_delayed_dark_adaptation0.83044470
99MP0005499_abnormal_olfactory_system0.81248767
100MP0005394_taste/olfaction_phenotype0.81248767
101MP0002210_abnormal_sex_determination0.80347158
102MP0002069_abnormal_eating/drinking_beha0.79847247
103MP0001764_abnormal_homeostasis0.79727190
104MP0003329_amyloid_beta_deposits0.79273916
105MP0001664_abnormal_digestion0.78572957
106MP0008775_abnormal_heart_ventricle0.77520456
107MP0008995_early_reproductive_senescence0.77446675
108MP0002752_abnormal_somatic_nervous0.76371073
109MP0005195_abnormal_posterior_eye0.76221174
110MP0005085_abnormal_gallbladder_physiolo0.76124155
111MP0008872_abnormal_physiological_respon0.76075830
112MP0002638_abnormal_pupillary_reflex0.75513673
113MP0000026_abnormal_inner_ear0.75384782
114MP0008874_decreased_physiological_sensi0.74609890
115MP0000015_abnormal_ear_pigmentation0.73809551
116MP0004085_abnormal_heartbeat0.72137087
117MP0002229_neurodegeneration0.70350901
118MP0005379_endocrine/exocrine_gland_phen0.69515227
119MP0001485_abnormal_pinna_reflex0.68942432
120MP0008004_abnormal_stomach_pH0.67916147
121MP0008877_abnormal_DNA_methylation0.66459199
122MP0006072_abnormal_retinal_apoptosis0.63290942
123MP0003632_abnormal_nervous_system0.62961490
124MP0003861_abnormal_nervous_system0.62080697
125MP0003938_abnormal_ear_development0.61752140
126MP0005367_renal/urinary_system_phenotyp0.61717108
127MP0000516_abnormal_urinary_system0.61717108
128MP0003183_abnormal_peptide_metabolism0.59497669
129MP0001299_abnormal_eye_distance/0.59443576
130MP0001943_abnormal_respiration0.59298201
131MP0005253_abnormal_eye_physiology0.59106479
132MP0005535_abnormal_body_temperature0.58129048
133MP0004215_abnormal_myocardial_fiber0.57176249
134MP0009697_abnormal_copulation0.55166226
135MP0000566_synostosis0.54656731
136MP0010770_preweaning_lethality0.54612333

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.28520600
2Epileptic encephalopathy (HP:0200134)5.67256297
3Febrile seizures (HP:0002373)5.34849847
4Hyperventilation (HP:0002883)5.18281182
5Focal seizures (HP:0007359)5.13644593
6Atonic seizures (HP:0010819)4.94775457
7Broad-based gait (HP:0002136)4.28450816
8Myokymia (HP:0002411)4.22348131
9Pancreatic cysts (HP:0001737)4.15796464
10Progressive cerebellar ataxia (HP:0002073)4.12979490
11Absence seizures (HP:0002121)4.08584390
12Pancreatic fibrosis (HP:0100732)3.82926927
13Poor eye contact (HP:0000817)3.74696585
14Visual hallucinations (HP:0002367)3.73423951
15Nephronophthisis (HP:0000090)3.69689689
16Dialeptic seizures (HP:0011146)3.65403578
17Generalized tonic-clonic seizures (HP:0002069)3.58156647
18True hermaphroditism (HP:0010459)3.54051006
19Protruding tongue (HP:0010808)3.48063346
20Drooling (HP:0002307)3.35231538
21Excessive salivation (HP:0003781)3.35231538
22Gaze-evoked nystagmus (HP:0000640)3.26782118
23Congenital stationary night blindness (HP:0007642)3.24069048
24Abnormality of the renal medulla (HP:0100957)3.15327023
25Abnormality of the renal cortex (HP:0011035)3.14180622
26Abnormal social behavior (HP:0012433)3.07008864
27Impaired social interactions (HP:0000735)3.07008864
28Type II lissencephaly (HP:0007260)2.97290146
29Abnormal hair whorl (HP:0010721)2.94538947
30Absent speech (HP:0001344)2.86900555
31Colon cancer (HP:0003003)2.70941776
32Truncal ataxia (HP:0002078)2.70383281
33Blue irides (HP:0000635)2.68957038
34Impaired smooth pursuit (HP:0007772)2.67904177
35Hypothermia (HP:0002045)2.64081909
36Cystic liver disease (HP:0006706)2.63436654
37Inability to walk (HP:0002540)2.62991610
38Amblyopia (HP:0000646)2.59345596
39Scanning speech (HP:0002168)2.55947718
40Genetic anticipation (HP:0003743)2.54618796
41Dysdiadochokinesis (HP:0002075)2.53389918
42Fair hair (HP:0002286)2.52831138
43Epileptiform EEG discharges (HP:0011182)2.52670602
44Renal cortical cysts (HP:0000803)2.52248385
45Stereotypic behavior (HP:0000733)2.48531837
46Abnormality of salivation (HP:0100755)2.48063968
47Action tremor (HP:0002345)2.46380104
48Attenuation of retinal blood vessels (HP:0007843)2.43463204
49Abnormal drinking behavior (HP:0030082)2.41842974
50Polydipsia (HP:0001959)2.41842974
51Generalized hypopigmentation of hair (HP:0011358)2.40966596
52Abnormality of macular pigmentation (HP:0008002)2.40002191
53Cerebellar dysplasia (HP:0007033)2.37973327
54Pendular nystagmus (HP:0012043)2.36329209
55Tubular atrophy (HP:0000092)2.35800565
56Abolished electroretinogram (ERG) (HP:0000550)2.31728737
57Large for gestational age (HP:0001520)2.29718584
58Methylmalonic acidemia (HP:0002912)2.29650564
59Fetal akinesia sequence (HP:0001989)2.29398342
60Anxiety (HP:0000739)2.24903613
61Diplopia (HP:0000651)2.23197025
62Abnormality of binocular vision (HP:0011514)2.23197025
63EEG with generalized epileptiform discharges (HP:0011198)2.22970594
64Widely spaced teeth (HP:0000687)2.22910658
65Dysmetria (HP:0001310)2.21329991
66Gastroesophageal reflux (HP:0002020)2.20210281
67Depression (HP:0000716)2.19210594
68Abnormality of ocular smooth pursuit (HP:0000617)2.18102247
69Abnormal eating behavior (HP:0100738)2.17886251
70Gait imbalance (HP:0002141)2.17560140
71Supranuclear gaze palsy (HP:0000605)2.16102111
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.15899882
73Progressive inability to walk (HP:0002505)2.15687764
74Hemiparesis (HP:0001269)2.13822013
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.13611616
76Deeply set eye (HP:0000490)2.13196651
77Impaired vibration sensation in the lower limbs (HP:0002166)2.12464037
78Acute necrotizing encephalopathy (HP:0006965)2.10233801
79Medial flaring of the eyebrow (HP:0010747)2.09823763
80Tubulointerstitial nephritis (HP:0001970)2.08672491
81Progressive macrocephaly (HP:0004481)2.07215433
82Postural instability (HP:0002172)2.07004665
83Bile duct proliferation (HP:0001408)2.06678365
84Abnormal biliary tract physiology (HP:0012439)2.06678365
85Lissencephaly (HP:0001339)2.06664496
86Increased CSF lactate (HP:0002490)2.03749540
87Anencephaly (HP:0002323)2.03399806
88Inappropriate behavior (HP:0000719)2.03049637
89Congenital hepatic fibrosis (HP:0002612)2.02306790
90Exotropia (HP:0000577)2.01878288
91Abnormal rod and cone electroretinograms (HP:0008323)2.01373714
92Methylmalonic aciduria (HP:0012120)2.01045419
93Intestinal atresia (HP:0011100)2.00999904
94Mitochondrial inheritance (HP:0001427)2.00622364
95Nephrogenic diabetes insipidus (HP:0009806)1.98156852
96Hypsarrhythmia (HP:0002521)1.97974097
97Obstructive sleep apnea (HP:0002870)1.97734142
98Ketoacidosis (HP:0001993)1.97709518
99Sclerocornea (HP:0000647)1.96321980
100Congenital primary aphakia (HP:0007707)1.96075158
101Autism (HP:0000717)1.94025723
102Postaxial foot polydactyly (HP:0001830)1.93783918
103Polyphagia (HP:0002591)1.91532541
104Narrow nasal bridge (HP:0000446)1.91259689
105Neoplasm of the adrenal cortex (HP:0100641)1.90679976
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.90000773
107Optic nerve hypoplasia (HP:0000609)1.89799700
108Urinary bladder sphincter dysfunction (HP:0002839)1.89702657
109Hyperinsulinemic hypoglycemia (HP:0000825)1.89231532
110Male pseudohermaphroditism (HP:0000037)1.88282675
111Acute encephalopathy (HP:0006846)1.87692251
112Abnormality of the labia minora (HP:0012880)1.85133135
113Long nose (HP:0003189)1.84945850
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84387898
115Tented upper lip vermilion (HP:0010804)1.84210076
116Amelogenesis imperfecta (HP:0000705)1.83681702
117Dysmetric saccades (HP:0000641)1.83546633
118Decreased central vision (HP:0007663)1.83143795
119Disproportionate short-trunk short stature (HP:0003521)1.83141732
120Aqueductal stenosis (HP:0002410)1.82618401
121Lipid accumulation in hepatocytes (HP:0006561)1.82438249
122Sleep apnea (HP:0010535)1.81965317
123Bradykinesia (HP:0002067)1.81000851
124Abnormal respiratory motile cilium morphology (HP:0005938)1.80368737
125Abnormal respiratory epithelium morphology (HP:0012253)1.80368737
126Bony spicule pigmentary retinopathy (HP:0007737)1.79821050
1273-Methylglutaconic aciduria (HP:0003535)1.79454935
128Absent/shortened dynein arms (HP:0200106)1.79295725
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.79295725
130Palpebral edema (HP:0100540)1.79269888
131Postaxial hand polydactyly (HP:0001162)1.79066155
132Polyuria (HP:0000103)1.77641764
133Abnormality of the pons (HP:0007361)1.77103028
134Gait ataxia (HP:0002066)1.76162168
135Ketosis (HP:0001946)1.75667115
136Abnormal ciliary motility (HP:0012262)1.74217354
137Status epilepticus (HP:0002133)1.72962003
138Absent eyebrow (HP:0002223)1.71732069
139Stomach cancer (HP:0012126)1.71668197
140Hyperthyroidism (HP:0000836)1.70309538
141Generalized myoclonic seizures (HP:0002123)1.70151949
142Agitation (HP:0000713)1.69635624
143Furrowed tongue (HP:0000221)1.68980123
144Hyperglycinemia (HP:0002154)1.68806568
145Thickened helices (HP:0000391)1.68128469
146Enlarged kidneys (HP:0000105)1.67835471
147Abnormal mitochondria in muscle tissue (HP:0008316)1.67338171
148Heterochromia iridis (HP:0001100)1.67286285
149Occipital encephalocele (HP:0002085)1.67236870
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65928946
151Abnormality of alanine metabolism (HP:0010916)1.65928946
152Hyperalaninemia (HP:0003348)1.65928946
153Hypomagnesemia (HP:0002917)1.65222117
154Esotropia (HP:0000565)1.63703779
155Open mouth (HP:0000194)1.63642450
156Incomplete penetrance (HP:0003829)1.63501799
157Genital tract atresia (HP:0001827)1.63218832
158Spinal canal stenosis (HP:0003416)1.62737973
159Impaired vibratory sensation (HP:0002495)1.59200309
160Molar tooth sign on MRI (HP:0002419)1.58402744
161Abnormality of midbrain morphology (HP:0002418)1.58402744
162Retinal dysplasia (HP:0007973)1.57331366
163Macroglossia (HP:0000158)1.56605006
164Aplasia involving bones of the extremities (HP:0009825)1.55865589
165Aplasia involving bones of the upper limbs (HP:0009823)1.55865589
166Aplasia of the phalanges of the hand (HP:0009802)1.55865589
167Chronic hepatic failure (HP:0100626)1.54474363
168Limb dystonia (HP:0002451)1.54472684
169Vaginal atresia (HP:0000148)1.52777026
170Megalencephaly (HP:0001355)1.51924557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.92890391
2EPHA44.75540044
3CASK4.39107782
4MAP2K73.24087873
5MAP3K43.03424728
6LATS12.88194791
7STK38L2.62921115
8MAP4K22.60058354
9MAP3K122.59543181
10RIPK42.55097394
11ZAK2.39820604
12ACVR1B2.38980614
13PLK22.24640892
14DAPK22.23167915
15TRIM282.10901611
16MARK12.06541015
17MINK12.00012495
18GRK11.95445861
19DAPK11.89580094
20NUAK11.82382845
21TNIK1.81635962
22PRPF4B1.81422863
23MAP2K41.80481321
24MAP3K91.79386611
25NTRK21.67636915
26MAPK131.64732109
27BMPR21.61156880
28AKT31.61095658
29PNCK1.60907299
30SGK21.56980079
31CDK31.52740136
32INSRR1.47987652
33CCNB11.47246490
34TLK11.38497836
35WNK41.37510412
36SIK31.30138906
37CAMKK21.29106777
38KSR11.26868326
39CDK191.26791318
40GRK51.26293664
41PAK31.21892036
42SGK2231.20679406
43SGK4941.20679406
44CDK51.19189450
45PRKCG1.17858649
46STK31.17530736
47STK391.17466772
48NLK1.17411649
49CAMKK11.15436271
50CSNK1G11.13368707
51SIK21.13295326
52CAMK2A1.11961565
53CSNK1A1L1.10768190
54TAOK31.08867405
55CAMK2B1.07867763
56PAK61.05045122
57CSNK1G31.04566836
58MST41.02643536
59PRKD31.01014266
60PLK41.00517094
61SGK30.97963105
62FES0.94692506
63MKNK10.93290303
64MAP3K60.89234273
65CAMK10.87509875
66TXK0.85010717
67PTK2B0.84239742
68DYRK1A0.83827282
69EIF2AK30.83411082
70SGK10.82642778
71VRK10.82163250
72ADRBK20.79211928
73NEK60.77556273
74OXSR10.75725531
75BRSK20.75094816
76DYRK20.74639845
77STK160.74355645
78NTRK10.73532688
79GRK70.72837095
80STK380.72617506
81PHKG10.70864187
82PHKG20.70864187
83ARAF0.70532634
84MKNK20.70424083
85PRKCE0.69395257
86NME10.66658901
87MAPK70.66041980
88TAOK20.64236352
89FRK0.63725162
90TGFBR10.62193243
91CDK180.61967220
92UHMK10.61479638
93NEK20.60978113
94NEK10.58619054
95MAPK150.56688762
96TNK20.55735526
97TAF10.55728319
98STK110.54705544
99BCKDK0.54388737
100MUSK0.54036336
101CDK150.53969143
102PLK10.53779661
103CSNK1D0.53460197
104SRPK10.52890755
105PINK10.52181473
106BCR0.50440747
107WEE10.49862896
108CDK140.49818425
109WNK30.49709630
110BRAF0.49525499
111CAMK2D0.49362805
112PRKCH0.48923854
113CAMK40.47586969
114RPS6KA20.47091620
115MAPKAPK50.46538886
116CAMK1G0.46118639
117ATM0.45491265
118CDK11A0.45139338
119FGFR20.45081455
120BRD40.44765066
121CAMK2G0.43592595
122PLK30.43586958
123KSR20.42942787
124OBSCN0.42587098
125PKN10.41959730
126PRKCQ0.41511762
127RAF10.41343024
128RPS6KA30.39634009
129CDK80.39171573
130PRKAA20.39119025
131MARK20.38920514
132ATR0.38251349
133MAP3K130.37133318
134PRKG10.36365080
135ADRBK10.35656671
136LATS20.35559295
137MELK0.35554629
138RPS6KB10.35407704
139BMPR1B0.33937644
140MAP3K20.32600816
141PRKACB0.31894363
142PRKACA0.31475261
143ERBB30.31389781
144MAPK100.30908865
145MAPK120.30328274
146CSNK1G20.30254774
147CSNK1A10.29794531
148TSSK60.29222772
149TIE10.27800295

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22665717
2Long-term potentiation_Homo sapiens_hsa047202.94770405
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92411304
4Synaptic vesicle cycle_Homo sapiens_hsa047212.83579355
5Circadian entrainment_Homo sapiens_hsa047132.79002798
6Amphetamine addiction_Homo sapiens_hsa050312.76820516
7Glutamatergic synapse_Homo sapiens_hsa047242.71445585
8Morphine addiction_Homo sapiens_hsa050322.62664791
9Olfactory transduction_Homo sapiens_hsa047402.60181672
10GABAergic synapse_Homo sapiens_hsa047272.57300081
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41736654
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.40478710
13Butanoate metabolism_Homo sapiens_hsa006502.35719493
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31565718
15Salivary secretion_Homo sapiens_hsa049702.23871427
16Taste transduction_Homo sapiens_hsa047422.18603695
17Dopaminergic synapse_Homo sapiens_hsa047282.13990318
18Insulin secretion_Homo sapiens_hsa049112.05919305
19Protein export_Homo sapiens_hsa030602.04772106
20Nitrogen metabolism_Homo sapiens_hsa009102.03424779
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01953989
22Serotonergic synapse_Homo sapiens_hsa047261.99865213
23Renin secretion_Homo sapiens_hsa049241.89692376
24Long-term depression_Homo sapiens_hsa047301.85222595
25Fanconi anemia pathway_Homo sapiens_hsa034601.83070488
26Homologous recombination_Homo sapiens_hsa034401.81092060
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80387638
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79326242
29Calcium signaling pathway_Homo sapiens_hsa040201.78310564
30Gastric acid secretion_Homo sapiens_hsa049711.77433350
31Cholinergic synapse_Homo sapiens_hsa047251.75244965
32Propanoate metabolism_Homo sapiens_hsa006401.73375981
33Basal transcription factors_Homo sapiens_hsa030221.71916025
34Collecting duct acid secretion_Homo sapiens_hsa049661.71486006
35Linoleic acid metabolism_Homo sapiens_hsa005911.68721819
36Oxytocin signaling pathway_Homo sapiens_hsa049211.66446845
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64983648
38Cocaine addiction_Homo sapiens_hsa050301.62867133
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59926443
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54677986
41RNA polymerase_Homo sapiens_hsa030201.49385876
42GnRH signaling pathway_Homo sapiens_hsa049121.42796340
43Ether lipid metabolism_Homo sapiens_hsa005651.42691557
44Phototransduction_Homo sapiens_hsa047441.40670413
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36493419
46cAMP signaling pathway_Homo sapiens_hsa040241.35952195
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33398338
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32757880
49Selenocompound metabolism_Homo sapiens_hsa004501.30809867
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30583342
51Tryptophan metabolism_Homo sapiens_hsa003801.27311654
52Non-homologous end-joining_Homo sapiens_hsa034501.25562787
53One carbon pool by folate_Homo sapiens_hsa006701.25035065
54Axon guidance_Homo sapiens_hsa043601.24271632
55Parkinsons disease_Homo sapiens_hsa050121.22486305
56RNA degradation_Homo sapiens_hsa030181.18787969
57Gap junction_Homo sapiens_hsa045401.15771003
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14185482
59Peroxisome_Homo sapiens_hsa041461.14060426
60Melanogenesis_Homo sapiens_hsa049161.11784608
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10530181
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09985154
63Caffeine metabolism_Homo sapiens_hsa002321.06063790
64Vibrio cholerae infection_Homo sapiens_hsa051101.06042309
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03751943
66Estrogen signaling pathway_Homo sapiens_hsa049151.02837025
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.00311770
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99832035
69ErbB signaling pathway_Homo sapiens_hsa040120.98862751
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.98011034
71beta-Alanine metabolism_Homo sapiens_hsa004100.96577971
72Glioma_Homo sapiens_hsa052140.96133283
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95724816
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95641330
75Sphingolipid metabolism_Homo sapiens_hsa006000.93760612
76Pancreatic secretion_Homo sapiens_hsa049720.93603624
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93548006
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91534566
79Type II diabetes mellitus_Homo sapiens_hsa049300.90558384
80Vitamin digestion and absorption_Homo sapiens_hsa049770.90233132
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.85031015
82ABC transporters_Homo sapiens_hsa020100.84949464
83Steroid biosynthesis_Homo sapiens_hsa001000.84219260
84Huntingtons disease_Homo sapiens_hsa050160.83717510
85Regulation of autophagy_Homo sapiens_hsa041400.83558058
86MAPK signaling pathway_Homo sapiens_hsa040100.83363113
87Purine metabolism_Homo sapiens_hsa002300.79605622
88African trypanosomiasis_Homo sapiens_hsa051430.77889807
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77430263
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77319352
91Oocyte meiosis_Homo sapiens_hsa041140.77264074
92Chemical carcinogenesis_Homo sapiens_hsa052040.74288588
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74254534
94Folate biosynthesis_Homo sapiens_hsa007900.74223258
95Choline metabolism in cancer_Homo sapiens_hsa052310.72507103
96Wnt signaling pathway_Homo sapiens_hsa043100.72395550
97Thyroid hormone synthesis_Homo sapiens_hsa049180.71939329
98Circadian rhythm_Homo sapiens_hsa047100.71436995
99Type I diabetes mellitus_Homo sapiens_hsa049400.70992664
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70934379
101Retinol metabolism_Homo sapiens_hsa008300.68058714
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67752341
103Dilated cardiomyopathy_Homo sapiens_hsa054140.67443718
104Ras signaling pathway_Homo sapiens_hsa040140.67121362
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.65730994
106Metabolic pathways_Homo sapiens_hsa011000.65641436
107Fatty acid elongation_Homo sapiens_hsa000620.64773626
108Fatty acid metabolism_Homo sapiens_hsa012120.63337834
109Inositol phosphate metabolism_Homo sapiens_hsa005620.62784402
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.62406867
111Fatty acid degradation_Homo sapiens_hsa000710.62132542
112Rap1 signaling pathway_Homo sapiens_hsa040150.61334076
113Cardiac muscle contraction_Homo sapiens_hsa042600.59727241
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59520234
115Arachidonic acid metabolism_Homo sapiens_hsa005900.59356492
116Glycerolipid metabolism_Homo sapiens_hsa005610.59272887
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58728433
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58655779
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58571582
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58516483
121Dorso-ventral axis formation_Homo sapiens_hsa043200.56374910
122Sulfur metabolism_Homo sapiens_hsa009200.54664065
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54185086
124Alcoholism_Homo sapiens_hsa050340.52762587
125Rheumatoid arthritis_Homo sapiens_hsa053230.52058938
126Mismatch repair_Homo sapiens_hsa034300.51810884
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51191583
128Glucagon signaling pathway_Homo sapiens_hsa049220.50826628
129Ovarian steroidogenesis_Homo sapiens_hsa049130.50362874
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.49607734
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47932591
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47228973
133Histidine metabolism_Homo sapiens_hsa003400.46105075
134Alzheimers disease_Homo sapiens_hsa050100.45485800
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44208044
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43343587
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43154938
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41634964
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41340614
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39486613
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36892080
142VEGF signaling pathway_Homo sapiens_hsa043700.35814343
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35706314
144Melanoma_Homo sapiens_hsa052180.35461334
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34414041
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.33683239
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32834799
148Colorectal cancer_Homo sapiens_hsa052100.31959629
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31946472
150Hedgehog signaling pathway_Homo sapiens_hsa043400.30167253
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28350118
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26378149
153Endometrial cancer_Homo sapiens_hsa052130.24317823
154Chemokine signaling pathway_Homo sapiens_hsa040620.23925483
155Platelet activation_Homo sapiens_hsa046110.23296259
156mTOR signaling pathway_Homo sapiens_hsa041500.23257998
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23177989
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21894498
159Non-small cell lung cancer_Homo sapiens_hsa052230.21842201
160Oxidative phosphorylation_Homo sapiens_hsa001900.21448600

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