ZC3H12C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrion distribution (GO:0048311)5.69956125
2NIK/NF-kappaB signaling (GO:0038061)5.56915300
3positive regulation by symbiont of host defense response (GO:0052509)5.42366770
4modulation by symbiont of host defense response (GO:0052031)5.42366770
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.42366770
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.42366770
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.42366770
8modulation by symbiont of host immune response (GO:0052553)5.42366770
9neutrophil activation involved in immune response (GO:0002283)5.31175609
10regulation of penile erection (GO:0060405)5.21816200
11response to peptidoglycan (GO:0032494)5.00748675
12response to muramyl dipeptide (GO:0032495)4.99208981
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97191697
14positive regulation of heat generation (GO:0031652)4.77706128
15positive regulation of cellular amide metabolic process (GO:0034250)4.69613360
16nerve growth factor signaling pathway (GO:0038180)4.69164804
17regulation of fever generation (GO:0031620)4.54840808
18specification of organ identity (GO:0010092)4.53364884
19granulocyte activation (GO:0036230)4.45188491
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.44275105
21regulation of dendritic cell antigen processing and presentation (GO:0002604)4.41860460
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.39130375
23positive regulation of chemokine biosynthetic process (GO:0045080)4.38773411
24prenylation (GO:0097354)4.35175173
25protein prenylation (GO:0018342)4.35175173
26regulation of NFAT protein import into nucleus (GO:0051532)4.35020481
27neutrophil activation (GO:0042119)4.31737689
28regulation of interleukin-12 biosynthetic process (GO:0045075)4.15266743
29hydrogen peroxide biosynthetic process (GO:0050665)4.14320174
30macrophage activation involved in immune response (GO:0002281)4.11409555
31natural killer cell mediated cytotoxicity (GO:0042267)4.10190578
32natural killer cell mediated immunity (GO:0002228)4.10190578
33lipopolysaccharide-mediated signaling pathway (GO:0031663)4.07956781
34positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.02117115
35superoxide anion generation (GO:0042554)3.93267214
36positive regulation of interleukin-12 production (GO:0032735)3.88212748
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87513026
38positive regulation of developmental pigmentation (GO:0048087)3.75258957
39positive regulation of humoral immune response (GO:0002922)3.71205978
40regulation of pigment cell differentiation (GO:0050932)3.68417252
41negative regulation of neurotransmitter secretion (GO:0046929)3.65245077
42hindbrain development (GO:0030902)3.65159230
43regulation of chemokine biosynthetic process (GO:0045073)3.58935488
44reactive oxygen species biosynthetic process (GO:1903409)3.58868087
45regulation of heat generation (GO:0031650)3.57354827
46regulation of mononuclear cell migration (GO:0071675)3.57349285
47positive regulation of interferon-alpha production (GO:0032727)3.57026143
48cytokine secretion (GO:0050663)3.54250545
49positive regulation of antigen processing and presentation (GO:0002579)3.52273487
50myeloid dendritic cell differentiation (GO:0043011)3.51148746
51respiratory burst (GO:0045730)3.50174276
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48281345
53response to host immune response (GO:0052572)3.48281345
54cellular response to nerve growth factor stimulus (GO:1990090)3.42476393
55response to nerve growth factor (GO:1990089)3.42476393
56positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.42471463
57regulation of interferon-alpha production (GO:0032647)3.40353978
58short-term memory (GO:0007614)3.40120669
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.38663020
60regulation of RIG-I signaling pathway (GO:0039535)3.36896842
61regulation of interleukin-1 beta secretion (GO:0050706)3.36840104
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36739567
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35918805
64neutrophil mediated immunity (GO:0002446)3.31642420
65detection of molecule of bacterial origin (GO:0032490)3.31249976
66negative regulation of lipid storage (GO:0010888)3.31248533
67regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.30660916
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29649267
69mitochondrion localization (GO:0051646)3.28902358
70regulation of vitamin D biosynthetic process (GO:0060556)3.23063933
71microglial cell activation (GO:0001774)3.22344870
72myeloid dendritic cell activation (GO:0001773)3.22280530
73T cell lineage commitment (GO:0002360)3.21691156
74positive regulation of gamma-delta T cell activation (GO:0046645)3.21058291
75regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.20238109
76regulation of interferon-beta biosynthetic process (GO:0045357)3.18790910
77regulation of interleukin-12 production (GO:0032655)3.18147150
78behavioral response to ethanol (GO:0048149)3.17484224
79regulation of chronic inflammatory response (GO:0002676)3.15034274
80leukocyte mediated cytotoxicity (GO:0001909)3.14266222
81positive regulation of interleukin-1 beta secretion (GO:0050718)3.12918838
82regulation of immunoglobulin secretion (GO:0051023)3.11727112
83response to host (GO:0075136)3.08788796
84response to host defenses (GO:0052200)3.08788796
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08788796
86regulation of cytokine secretion involved in immune response (GO:0002739)3.06859631
87positive regulation of interferon-beta production (GO:0032728)3.06698186
88macrophage activation (GO:0042116)3.06687233
89myeloid cell activation involved in immune response (GO:0002275)3.04380464
90positive regulation of p38MAPK cascade (GO:1900745)3.04349036
91positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.04332845
92response to lipoprotein particle (GO:0055094)3.04184209
93positive regulation of nitric oxide biosynthetic process (GO:0045429)3.03671987
94I-kappaB phosphorylation (GO:0007252)3.01664543
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00925721
96negative regulation of interleukin-12 production (GO:0032695)2.98992526
97Rap protein signal transduction (GO:0032486)2.97368868
98sarcoplasmic reticulum calcium ion transport (GO:0070296)2.97197654
99positive regulation of T cell cytokine production (GO:0002726)2.96523790
100monocyte chemotaxis (GO:0002548)2.96019076
101regulation of antigen processing and presentation (GO:0002577)2.94140887
102regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.93836623
103T-helper cell differentiation (GO:0042093)2.92035180
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.92035180
105positive regulation of vasculogenesis (GO:2001214)2.90663884
106interferon-gamma-mediated signaling pathway (GO:0060333)2.90632940
107cell adhesion mediated by integrin (GO:0033627)2.89482612
108positive regulation of interleukin-1 beta production (GO:0032731)2.87756989
109negative regulation of interleukin-17 production (GO:0032700)2.87001881
110cellular response to zinc ion (GO:0071294)2.86434731
111regulation of interleukin-1 secretion (GO:0050704)2.86394164
112positive regulation of interleukin-1 secretion (GO:0050716)2.86244833
113positive regulation of type 2 immune response (GO:0002830)2.86023028
114regulation of monocyte differentiation (GO:0045655)2.85877744
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85640039
116activation of MAPKKK activity (GO:0000185)2.83957264
117germinal center formation (GO:0002467)2.82433362
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82198807
119regulation of integrin activation (GO:0033623)2.82071001
120immunoglobulin mediated immune response (GO:0016064)2.81376109
121dendritic cell differentiation (GO:0097028)2.79550016
122positive regulation of chemokine production (GO:0032722)2.79505653
123positive regulation of acute inflammatory response (GO:0002675)2.78261321
124negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77431497
125myeloid leukocyte mediated immunity (GO:0002444)2.76492792
126regulation of vitamin metabolic process (GO:0030656)2.76056997
127positive regulation of RNA splicing (GO:0033120)2.75984513
128T-helper 1 type immune response (GO:0042088)2.74482749
129regulation of T-helper 1 cell differentiation (GO:0045625)2.73856999
130positive regulation of interleukin-6 production (GO:0032755)2.72973816
131eosinophil chemotaxis (GO:0048245)2.72052970
132myeloid leukocyte activation (GO:0002274)2.71278202
133histone H3-K4 trimethylation (GO:0080182)2.71123395
134cellular response to arsenic-containing substance (GO:0071243)2.69547989
135chemosensory behavior (GO:0007635)2.66076693
136positive regulation of macrophage cytokine production (GO:0060907)2.65496676
137positive regulation of cell size (GO:0045793)2.65427840
138fibroblast migration (GO:0010761)2.64471562
139positive regulation of NF-kappaB import into nucleus (GO:0042346)2.63627747
140cellular response to nicotine (GO:0071316)2.63553129
141regulation of alkaline phosphatase activity (GO:0010692)2.58653222
142regulation of lymphocyte chemotaxis (GO:1901623)2.58327963
143regulation of vascular permeability (GO:0043114)2.56633621
144regulation of membrane protein ectodomain proteolysis (GO:0051043)2.50723148
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47368402
146establishment of endothelial barrier (GO:0061028)2.45563498
147cellular response to ethanol (GO:0071361)2.45075495
148positive regulation of signal transduction by p53 class mediator (GO:1901798)2.43720356
149negative regulation of necrotic cell death (GO:0060547)2.43558459
150response to histamine (GO:0034776)2.42644505
151positive regulation of interleukin-2 production (GO:0032743)2.42157272
152sphingosine metabolic process (GO:0006670)2.41591921
153negative regulation of neurotransmitter transport (GO:0051589)2.41528593
154cellular response to lipopolysaccharide (GO:0071222)2.41383807
155positive regulation of neurotransmitter transport (GO:0051590)2.40887458
156regulation of macrophage cytokine production (GO:0010935)2.40857785
157response to inactivity (GO:0014854)2.34928842
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.34695881
159vesicle transport along microtubule (GO:0047496)2.34629311
160icosanoid secretion (GO:0032309)2.34343572
161arachidonic acid secretion (GO:0050482)2.34343572
162negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33267780
163regulation of interferon-gamma biosynthetic process (GO:0045072)2.32094925
164cellular response to molecule of bacterial origin (GO:0071219)2.32019002
165regulation of protein polyubiquitination (GO:1902914)2.30637510
166regulation of podosome assembly (GO:0071801)2.28743611
167ganglion development (GO:0061548)2.26230679
168regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.26155283
169regulation of T-helper cell differentiation (GO:0045622)2.25850879
170regulation of DNA-templated transcription, initiation (GO:2000142)2.24107976
171cellular response to type I interferon (GO:0071357)2.24021974
172type I interferon signaling pathway (GO:0060337)2.24021974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40444142
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.10857569
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.82338062
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.83631214
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.76743953
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75069842
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72383115
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.69417382
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50844468
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47558381
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.32002556
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.29515158
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12903709
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08173886
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82654679
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65734604
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52825891
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38471639
19GBX2_23144817_ChIP-Seq_PC3_Human2.32919628
20VDR_24787735_ChIP-Seq_THP-1_Human2.26263275
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19601375
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90462728
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87219282
24PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83701103
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81416321
26RUNX_20019798_ChIP-Seq_JUKART_Human1.80952279
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.79970824
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77238324
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70358499
30TP53_16413492_ChIP-PET_HCT116_Human1.69545128
31* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67508610
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55765364
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.54051119
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51703981
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50836799
36PU_27001747_Chip-Seq_BMDM_Mouse1.50621989
37TAF15_26573619_Chip-Seq_HEK293_Human1.46839730
38SMAD4_21799915_ChIP-Seq_A2780_Human1.46189382
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.46181276
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43631082
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41516971
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.41044811
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40236323
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38624321
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38292872
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38253692
47SPI1_23127762_ChIP-Seq_K562_Human1.36202821
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35465610
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35129172
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34233097
51SPI1_23547873_ChIP-Seq_NB4_Human1.31886015
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28737733
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28737733
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26213623
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.26059929
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25272235
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22652605
58VDR_24763502_ChIP-Seq_THP-1_Human1.21094708
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20217077
60MYB_26560356_Chip-Seq_TH2_Human1.19364885
61* TP63_23658742_ChIP-Seq_EP156T_Human1.17442341
62GATA1_22025678_ChIP-Seq_K562_Human1.17439292
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17323676
64STAT3_23295773_ChIP-Seq_U87_Human1.16784594
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15358423
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.13063004
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.12085422
68EZH2_22144423_ChIP-Seq_EOC_Human1.11869273
69GATA3_26560356_Chip-Seq_TH2_Human1.11546131
70CJUN_26792858_Chip-Seq_BT549_Human1.10018898
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09754158
72GATA3_27048872_Chip-Seq_THYMUS_Human1.09669986
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09568863
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09414864
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08520180
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07189354
77IGF1R_20145208_ChIP-Seq_DFB_Human1.07065619
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06317976
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05932629
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05409526
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05318724
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03540190
83FUS_26573619_Chip-Seq_HEK293_Human1.03180803
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02703185
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01220485
86MYB_26560356_Chip-Seq_TH1_Human1.00957986
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.00951246
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00522333
89* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97379076
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94585895
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94438335
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93180470
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.93132923
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92759267
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92731665
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92712254
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92712254
98ER_23166858_ChIP-Seq_MCF-7_Human0.92697151
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91898283
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91769515
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90768363
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.90734163
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89737487
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.89692131
105SMRT_27268052_Chip-Seq_Bcells_Human0.89062414
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88860668
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88523972
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88413591
109RXR_22108803_ChIP-Seq_LS180_Human0.88149243
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87479708
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.86798660
112PU1_27457419_Chip-Seq_LIVER_Mouse0.86242848
113AHR_22903824_ChIP-Seq_MCF-7_Human0.85963886
114SCL_19346495_ChIP-Seq_HPC-7_Human0.85717674
115BRD4_25478319_ChIP-Seq_HGPS_Human0.84675248
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.83639943
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83033490
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82307165
119P53_22387025_ChIP-Seq_ESCs_Mouse0.81788175
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.80865232
121NMYC_18555785_Chip-Seq_ESCs_Mouse0.79796826
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79761873
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78836680
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.78656992
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78382244
126* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78233180
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.76676763
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76499114
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.76260003
130* P300_19829295_ChIP-Seq_ESCs_Human0.75708411
131* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75448782
132TP53_18474530_ChIP-ChIP_U2OS_Human0.74612824
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.74224908
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73491756
135MAF_26560356_Chip-Seq_TH1_Human0.73022325
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72649147
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72600666
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.72314472
139* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70949974
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.70523154
141* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69661854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.68082742
2MP0001835_abnormal_antigen_presentation4.48060929
3MP0003436_decreased_susceptibility_to3.63067865
4MP0004510_myositis3.52184594
5MP0009785_altered_susceptibility_to3.48870561
6MP0002148_abnormal_hypersensitivity_rea3.38135972
7MP0002138_abnormal_hepatobiliary_system3.22947983
8MP0002254_reproductive_system_inflammat3.21295153
9MP0002419_abnormal_innate_immunity2.98109497
10MP0005000_abnormal_immune_tolerance2.97668211
11MP0003303_peritoneal_inflammation2.93454858
12MP0000685_abnormal_immune_system2.79916675
13MP0001790_abnormal_immune_system2.77933557
14MP0005387_immune_system_phenotype2.77933557
15MP0002452_abnormal_antigen_presenting2.55856406
16MP0005025_abnormal_response_to2.53372363
17MP0001800_abnormal_humoral_immune2.42210877
18MP0002723_abnormal_immune_serum2.36235317
19MP0002006_tumorigenesis2.25838409
20MP0006082_CNS_inflammation2.25756489
21MP0002277_abnormal_respiratory_mucosa2.25744312
22MP0003724_increased_susceptibility_to2.23393677
23MP0004947_skin_inflammation2.22960801
24MP0005671_abnormal_response_to2.21910758
25MP0002139_abnormal_hepatobiliary_system2.20432208
26MP0001819_abnormal_immune_cell2.05813751
27MP0005310_abnormal_salivary_gland2.04017853
28MP0002420_abnormal_adaptive_immunity2.01367291
29MP0009278_abnormal_bone_marrow2.00049487
30MP0002928_abnormal_bile_duct1.95899744
31MP0002877_abnormal_melanocyte_morpholog1.95782207
32MP0005623_abnormal_meninges_morphology1.89545320
33MP0009764_decreased_sensitivity_to1.85175528
34MP0005423_abnormal_somatic_nervous1.83761115
35MP0003172_abnormal_lysosome_physiology1.76535468
36MP0005076_abnormal_cell_differentiation1.73844123
37MP0005248_abnormal_Harderian_gland1.71434328
38MP0001533_abnormal_skeleton_physiology1.68595458
39MP0000462_abnormal_digestive_system1.67987144
40MP0009840_abnormal_foam_cell1.67301971
41MP0005058_abnormal_lysosome_morphology1.64287820
42MP0003448_altered_tumor_morphology1.62755314
43MP0000371_diluted_coat_color1.59928311
44MP0001845_abnormal_inflammatory_respons1.58390537
45MP0003183_abnormal_peptide_metabolism1.57580507
46MP0002166_altered_tumor_susceptibility1.56797625
47MP0003252_abnormal_bile_duct1.53849100
48MP0010678_abnormal_skin_adnexa1.53068156
49MP0003950_abnormal_plasma_membrane1.52349611
50MP0005464_abnormal_platelet_physiology1.52347398
51MP0001853_heart_inflammation1.52291645
52MP0002405_respiratory_system_inflammati1.52076413
53MP0000383_abnormal_hair_follicle1.48601086
54MP0002163_abnormal_gland_morphology1.46791579
55MP0002998_abnormal_bone_remodeling1.44558967
56MP0000716_abnormal_immune_system1.41476589
57MP0008260_abnormal_autophagy1.40128342
58MP0005174_abnormal_tail_pigmentation1.36487178
59MP0000013_abnormal_adipose_tissue1.35244783
60MP0001545_abnormal_hematopoietic_system1.34786206
61MP0005397_hematopoietic_system_phenotyp1.34786206
62MP0000015_abnormal_ear_pigmentation1.34285872
63MP0001299_abnormal_eye_distance/1.32612909
64MP0000778_abnormal_nervous_system1.32565820
65MP0004145_abnormal_muscle_electrophysio1.31288819
66MP0008004_abnormal_stomach_pH1.29245693
67MP0008469_abnormal_protein_level1.29082939
68MP0010155_abnormal_intestine_physiology1.25218119
69MP0002398_abnormal_bone_marrow1.25034257
70MP0003453_abnormal_keratinocyte_physiol1.23796597
71MP0005451_abnormal_body_composition1.22598396
72MP0003828_pulmonary_edema1.21950847
73MP0001348_abnormal_lacrimal_gland1.21678983
74MP0003091_abnormal_cell_migration1.19772777
75MP0001346_abnormal_lacrimal_gland1.15277342
76MP0000858_altered_metastatic_potential1.14668454
77MP0002009_preneoplasia1.11513817
78MP0005167_abnormal_blood-brain_barrier1.08190952
79MP0002233_abnormal_nose_morphology1.07737535
80MP0010307_abnormal_tumor_latency1.07353820
81MP0010368_abnormal_lymphatic_system1.02617290
82MP0002429_abnormal_blood_cell1.01889262
83MP0008057_abnormal_DNA_replication0.99654401
84MP0003656_abnormal_erythrocyte_physiolo0.98521425
85MP0003075_altered_response_to0.95201399
86MP0002638_abnormal_pupillary_reflex0.94250267
87MP0003634_abnormal_glial_cell0.94199085
88MP0000372_irregular_coat_pigmentation0.90976872
89MP0001879_abnormal_lymphatic_vessel0.87802536
90MP0005390_skeleton_phenotype0.87800924
91MP0010352_gastrointestinal_tract_polyps0.87429155
92MP0005379_endocrine/exocrine_gland_phen0.86332189
93MP0003195_calcinosis0.86155111
94MP0008961_abnormal_basal_metabolism0.85251968
95MP0000689_abnormal_spleen_morphology0.84812536
96MP0005647_abnormal_sex_gland0.84337822
97MP0002177_abnormal_outer_ear0.82635526
98MP0000767_abnormal_smooth_muscle0.82447706
99MP0003300_gastrointestinal_ulcer0.82245019
100MP0005408_hypopigmentation0.81876265
101MP0003646_muscle_fatigue0.81212219
102MP0005595_abnormal_vascular_smooth0.80549914
103MP0002092_abnormal_eye_morphology0.78890002
104MP0003329_amyloid_beta_deposits0.78623328
105MP0000747_muscle_weakness0.78179617
106MP0004270_analgesia0.78006455
107MP0010234_abnormal_vibrissa_follicle0.76117473
108MP0000604_amyloidosis0.75985439
109MP0002722_abnormal_immune_system0.75195196
110MP0005257_abnormal_intraocular_pressure0.74668499
111MP0005164_abnormal_response_to0.73096512
112MP0000343_altered_response_to0.73080786
113MP0005266_abnormal_metabolism0.72864179
114MP0001293_anophthalmia0.72259306
115MP0005197_abnormal_uvea_morphology0.72139428
116MP0004215_abnormal_myocardial_fiber0.70776659
117MP0002693_abnormal_pancreas_physiology0.70455628
118MP0005220_abnormal_exocrine_pancreas0.70395756
119MP0002095_abnormal_skin_pigmentation0.70285662
120MP0001440_abnormal_grooming_behavior0.69835049
121MP0010386_abnormal_urinary_bladder0.69660668
122MP0009333_abnormal_splenocyte_physiolog0.69458699
123MP0004782_abnormal_surfactant_physiolog0.69433545
124MP0000627_abnormal_mammary_gland0.69415157
125MP0003633_abnormal_nervous_system0.68012369
126MP0000249_abnormal_blood_vessel0.67862480
127MP0003943_abnormal_hepatobiliary_system0.66921433
128MP0009763_increased_sensitivity_to0.66032418
129MP0002168_other_aberrant_phenotype0.65815853
130MP0000955_abnormal_spinal_cord0.65647598
131MP0002972_abnormal_cardiac_muscle0.65586315
132MP0004808_abnormal_hematopoietic_stem0.64968770
133MP0001873_stomach_inflammation0.64601464
134MP0002332_abnormal_exercise_endurance0.61622526
135MP0005171_absent_coat_pigmentation0.61441923
136MP0001186_pigmentation_phenotype0.60027422
137MP0002933_joint_inflammation0.59749572
138MP0005166_decreased_susceptibility_to0.59589324
139MP0003045_fibrosis0.58823484
140MP0001851_eye_inflammation0.58769318
141MP0003795_abnormal_bone_structure0.56127980
142MP0000733_abnormal_muscle_development0.52014224
143MP0003191_abnormal_cellular_cholesterol0.50832889
144MP0001324_abnormal_eye_pigmentation0.50028777

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.99611997
2Recurrent abscess formation (HP:0002722)6.97918369
3Eczematoid dermatitis (HP:0000976)6.65982201
4Recurrent gram-negative bacterial infections (HP:0005420)5.94081001
5Mediastinal lymphadenopathy (HP:0100721)5.80956470
6Abnormality of macrophages (HP:0004311)4.78841046
7Optic neuritis (HP:0100653)4.50137570
8Retrobulbar optic neuritis (HP:0100654)4.50137570
9Elevated erythrocyte sedimentation rate (HP:0003565)4.45439539
10Stomatitis (HP:0010280)4.39983839
11Vertebral arch anomaly (HP:0008438)4.34532157
12Gingivitis (HP:0000230)4.28733713
13Large earlobe (HP:0009748)4.15194372
14Orchitis (HP:0100796)4.12180303
15Recurrent skin infections (HP:0001581)4.07801966
16Recurrent fungal infections (HP:0002841)3.99460317
17Autoimmune thrombocytopenia (HP:0001973)3.93815798
18Prostate neoplasm (HP:0100787)3.92996796
19Vasculitis (HP:0002633)3.71236829
20Increased IgM level (HP:0003496)3.60651748
21Recurrent viral infections (HP:0004429)3.60451017
22Myositis (HP:0100614)3.56830422
23Thick nail (HP:0001805)3.56731330
24Periodontitis (HP:0000704)3.54446807
25Obstructive lung disease (HP:0006536)3.44059885
26Chronic obstructive pulmonary disease (HP:0006510)3.44059885
27Pulmonary infiltrates (HP:0002113)3.42962622
28Hematochezia (HP:0002573)3.34287182
29Apathy (HP:0000741)3.28164631
30Fetal akinesia sequence (HP:0001989)3.28120375
31Abnormal pancreas size (HP:0012094)3.15709089
32Tented upper lip vermilion (HP:0010804)3.15701714
33Myocardial infarction (HP:0001658)2.93749279
34Papillary thyroid carcinoma (HP:0002895)2.92363612
35Gastrointestinal infarctions (HP:0005244)2.91979311
36Recurrent cutaneous fungal infections (HP:0011370)2.88704732
37Chronic mucocutaneous candidiasis (HP:0002728)2.88704732
38Tetraparesis (HP:0002273)2.87339907
39Leukocytosis (HP:0001974)2.84112573
40Diminished motivation (HP:0000745)2.83445492
41Neurofibrillary tangles (HP:0002185)2.81900823
42Arterial thrombosis (HP:0004420)2.81229711
43Tongue fasciculations (HP:0001308)2.78127021
44Cubitus valgus (HP:0002967)2.69794399
45Exocrine pancreatic insufficiency (HP:0001738)2.65476034
46Basal ganglia calcification (HP:0002135)2.64373134
47Gastrointestinal stroma tumor (HP:0100723)2.62309990
48Porencephaly (HP:0002132)2.59374236
49Premature loss of primary teeth (HP:0006323)2.59148255
50Abnormality of the right ventricle (HP:0001707)2.57504415
51Thoracolumbar scoliosis (HP:0002944)2.57366246
52Cellulitis (HP:0100658)2.53657409
53Abnormality of the nasal septum (HP:0000419)2.47997659
54Osteomyelitis (HP:0002754)2.42716600
55Recurrent pneumonia (HP:0006532)2.40954968
56Flattened epiphyses (HP:0003071)2.39981921
57Submucous cleft hard palate (HP:0000176)2.39770192
58Pulmonic stenosis (HP:0001642)2.39584394
59Gingival bleeding (HP:0000225)2.39542832
60Urticaria (HP:0001025)2.38403908
61Inappropriate behavior (HP:0000719)2.36852853
62Widely spaced teeth (HP:0000687)2.35468953
63Stomach cancer (HP:0012126)2.34552054
64Drooling (HP:0002307)2.34088731
65Keratoconjunctivitis sicca (HP:0001097)2.33804732
66Retinal atrophy (HP:0001105)2.33344412
67Loss of speech (HP:0002371)2.32470570
68Anhidrosis (HP:0000970)2.27048858
69Increased cerebral lipofuscin (HP:0011813)2.25993950
70Muscle fibrillation (HP:0010546)2.25382811
71Abnormality of the fingertips (HP:0001211)2.24475221
72Meningitis (HP:0001287)2.24249546
73Excessive salivation (HP:0003781)2.23639774
74Cortical dysplasia (HP:0002539)2.23571206
75IgA deficiency (HP:0002720)2.22201009
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.21815891
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.20241947
78Bone pain (HP:0002653)2.20080615
79Axonal loss (HP:0003447)2.19026645
80Abnormality of salivation (HP:0100755)2.17839591
81Osteolytic defects of the hand bones (HP:0009699)2.17771611
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.17771611
83Muscle fiber inclusion bodies (HP:0100299)2.17530066
84Keratoconjunctivitis (HP:0001096)2.16882811
85Interstitial pulmonary disease (HP:0006530)2.16606623
86Pustule (HP:0200039)2.16108544
87Eosinophilia (HP:0001880)2.15532771
88Esophageal varix (HP:0002040)2.13236493
89Pulmonary artery stenosis (HP:0004415)2.12802901
90Alveolar cell carcinoma (HP:0006519)2.12003658
91Vacuolated lymphocytes (HP:0001922)2.11534503
92Hypergammaglobulinemia (HP:0010702)2.11526429
93Esotropia (HP:0000565)2.10041925
94Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08834358
95Blue irides (HP:0000635)2.08557702
96Xerostomia (HP:0000217)2.07482122
97Poor eye contact (HP:0000817)2.07012307
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06773934
99Thoracic kyphosis (HP:0002942)2.06602170
100Barrel-shaped chest (HP:0001552)2.04471313
101Nemaline bodies (HP:0003798)2.03369189
102Neoplasm of the tracheobronchial system (HP:0100552)2.02216361
103Frequent falls (HP:0002359)2.01059156
104Peritonitis (HP:0002586)1.99818488
105Hemoptysis (HP:0002105)1.99348762
106Subaortic stenosis (HP:0001682)1.98351078
107Abnormality of the left ventricular outflow tract (HP:0011103)1.98351078
108Colitis (HP:0002583)1.98311718
109Mutism (HP:0002300)1.98107031
110Tracheomalacia (HP:0002779)1.96500867
111Irregular vertebral endplates (HP:0003301)1.96204294
112Disinhibition (HP:0000734)1.95298201
113Systemic lupus erythematosus (HP:0002725)1.94668849
114Absent frontal sinuses (HP:0002688)1.93591466
115Recurrent lower respiratory tract infections (HP:0002783)1.93380340
116Albinism (HP:0001022)1.93009407
117Shawl scrotum (HP:0000049)1.89260634
118Progressive visual loss (HP:0000529)1.89032088
119Calf muscle hypertrophy (HP:0008981)1.88979117
120Bladder neoplasm (HP:0009725)1.87355123
121Bladder carcinoma (HP:0002862)1.87355123
122Restrictive lung disease (HP:0002091)1.87082949
123Chronic hepatic failure (HP:0100626)1.86207378
124Rimmed vacuoles (HP:0003805)1.86130380
125Muscle hypertrophy of the lower extremities (HP:0008968)1.83482714
126Thyroid carcinoma (HP:0002890)1.82851698
127Abnormality of the pericardium (HP:0001697)1.82815220
128Absent hand (HP:0004050)1.82272968
129Vertebral compression fractures (HP:0002953)1.82165591
130Transitional cell carcinoma of the bladder (HP:0006740)1.80297779
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78290341
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77524362
133Arthralgia (HP:0002829)1.76168335
134Onycholysis (HP:0001806)1.76018431
135Cerebral inclusion bodies (HP:0100314)1.75929971
136Joint swelling (HP:0001386)1.75357685
137Pheochromocytoma (HP:0002666)1.75167994
138Abnormality of the prostate (HP:0008775)1.74645500
139Abnormality of glycolipid metabolism (HP:0010969)1.74500603
140Abnormality of liposaccharide metabolism (HP:0010968)1.74500603
141Abnormality of glycosphingolipid metabolism (HP:0004343)1.74500603
142Progressive sensorineural hearing impairment (HP:0000408)1.74130746
143Natal tooth (HP:0000695)1.74085410
144Portal hypertension (HP:0001409)1.74063221
145Absent speech (HP:0001344)1.73949838
146Abnormality of the hepatic vasculature (HP:0006707)1.72713973
147Recurrent sinusitis (HP:0011108)1.72555642
148Megalencephaly (HP:0001355)1.71712477
149Abnormality of eosinophils (HP:0001879)1.70759262
150Thyroiditis (HP:0100646)1.70040962
151Sepsis (HP:0100806)1.70013285
152Abnormality of the periventricular white matter (HP:0002518)1.69160765
153Fatigue (HP:0012378)1.68633967
154Truncal obesity (HP:0001956)1.68402279
155Granulocytopenia (HP:0001913)1.68246951
156Increased CSF protein (HP:0002922)1.68071796
157Protruding tongue (HP:0010808)1.67576670
158Acrocyanosis (HP:0001063)1.66574631
159Hypoplasia of the iris (HP:0007676)1.66557453
160Limited hip movement (HP:0008800)1.65191305
161Abnormality of the endocardium (HP:0004306)1.64372544
162Spastic tetraparesis (HP:0001285)1.64171114
163Round face (HP:0000311)1.64132812
164Asymmetric septal hypertrophy (HP:0001670)1.63791121
165Autoimmune hemolytic anemia (HP:0001890)1.63469717
166Shoulder girdle muscle weakness (HP:0003547)1.62728114
167Abnormality of the pleura (HP:0002103)1.62702904
168Glomerulonephritis (HP:0000099)1.62661446
169Myoglobinuria (HP:0002913)1.61804855
170Persistence of primary teeth (HP:0006335)1.61803466
171Amyloidosis (HP:0011034)1.61749833
172Action tremor (HP:0002345)1.61419090
173Renal tubular acidosis (HP:0001947)1.59265251
174Abnormality of the gastric mucosa (HP:0004295)1.57990338
175Febrile seizures (HP:0002373)1.57964442
176Cerebral hemorrhage (HP:0001342)1.57705306
177Acute myeloid leukemia (HP:0004808)1.55671125
178Personality changes (HP:0000751)1.55670860
179Abnormality of the hip-girdle musculature (HP:0001445)1.54771351
180Abnormality of the musculature of the pelvis (HP:0001469)1.54771351
181Leiomyosarcoma (HP:0100243)1.52842397
182Uterine leiomyosarcoma (HP:0002891)1.52842397
183Short 4th metacarpal (HP:0010044)1.52733512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B8.93515610
2MAP3K145.88181948
3TAOK25.21424808
4RIPK44.33731810
5IKBKB3.47077332
6IRAK43.38779312
7TBK13.27068631
8CHUK3.10467595
9IRAK33.09173200
10TYK23.00215773
11IKBKE2.96309284
12JAK32.72216911
13MAP3K132.62103041
14BMPR22.52026360
15SIK32.23489549
16JAK12.17549315
17LMTK22.14345520
18DDR22.02778511
19PBK1.96743245
20STK241.86273966
21TAOK31.78420283
22ERBB31.67830564
23EIF2AK31.58416649
24RPS6KA41.56032971
25MARK11.51702155
26NEK91.44954846
27TXK1.44276726
28CDK191.43179624
29OBSCN1.42588051
30FGFR31.35113290
31BLK1.26254342
32PDGFRA1.26251095
33INSRR1.25042001
34BCR1.24654811
35KIT1.19350341
36EIF2AK21.17109065
37EEF2K1.11535334
38TGFBR11.10410843
39CDK121.09662690
40ZAK1.07227938
41IRAK11.06355653
42YES11.04961938
43PIM11.02216843
44IRAK21.00968568
45LATS20.99803359
46MKNK10.96232311
47MAP4K10.94706940
48MKNK20.93797216
49PKN10.93238080
50TRPM70.91728030
51MAP3K50.91727736
52JAK20.90261412
53CDK80.89504777
54MAP3K40.89011439
55BMPR1B0.88978227
56NUAK10.88417024
57SGK20.87714873
58PHKG10.87363487
59PHKG20.87363487
60STK38L0.87152025
61EPHB20.85660733
62STK30.83646471
63CAMK1G0.83494738
64MARK30.83376662
65GRK70.82336581
66DMPK0.81735934
67BMX0.81145743
68AKT30.80447358
69CCNB10.80198990
70TNIK0.79656115
71PLK20.77155187
72SYK0.75934525
73EPHA30.75430377
74STK40.75330966
75FGFR40.74646026
76PIM20.74632117
77CAMK1D0.73551958
78ERBB40.71457919
79KSR10.70924930
80TYRO30.70901300
81CSK0.70709981
82HCK0.70438187
83CSF1R0.70227020
84LCK0.69336640
85PNCK0.68644177
86MOS0.68438378
87PTK60.66907989
88SGK30.63893469
89PRKCD0.62956749
90MAPK70.62276878
91EGFR0.61792978
92SGK10.60190621
93MELK0.59435531
94LYN0.59369267
95CASK0.59338268
96MAP3K100.58061210
97TTN0.57797854
98PRKCH0.55120190
99PRKAA10.53589619
100ZAP700.53575685
101MAP2K70.53126649
102ABL20.52616631
103MAPK110.51943666
104MST1R0.51246416
105FRK0.50204482
106ABL10.49883741
107MAPK120.49864223
108SIK20.49719818
109BTK0.49456995
110FGR0.48748285
111ADRBK20.48566819
112CDC42BPA0.45748332
113PRKAA20.44997058
114PRKCQ0.44505170
115TEC0.44421767
116PDGFRB0.44139940
117EPHB10.43927524
118PRKCE0.42927934
119MAPKAPK20.42504198
120GSK3A0.42215754
121MAPKAPK30.42064105
122PRKCZ0.39618619
123MAP3K90.38675527
124NEK60.38327530
125MAPK40.35154104
126MATK0.33250193
127SGK4940.33097579
128SGK2230.33097579
129HIPK20.32984379
130MAP3K60.32676115
131MAP4K20.32301473
132MAP3K70.31941969
133AKT10.30426732
134MAPKAPK50.30341074
135CDK90.29028893
136ACVR1B0.28352607
137OXSR10.27928305
138RPS6KA60.27796354
139DAPK20.26819793
140TAOK10.26804582
141RPS6KA50.26706887
142RPS6KA10.26108718
143CSNK1A1L0.25935757
144STK110.25365638
145RPS6KA20.24441765
146BRD40.22816315
147WNK10.22522918
148CDK60.21761692
149ERN10.19025894
150LATS10.18602135
151IGF1R0.18181217
152TGFBR20.17681852

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.16914929
2Leishmaniasis_Homo sapiens_hsa051403.16456076
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.12896644
4NOD-like receptor signaling pathway_Homo sapiens_hsa046213.05218794
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.71178714
6Legionellosis_Homo sapiens_hsa051342.67603050
7Allograft rejection_Homo sapiens_hsa053302.56368967
8TNF signaling pathway_Homo sapiens_hsa046682.46944243
9Type I diabetes mellitus_Homo sapiens_hsa049402.31096648
10Osteoclast differentiation_Homo sapiens_hsa043802.29615528
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12053229
12Rheumatoid arthritis_Homo sapiens_hsa053232.11983783
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.11664975
14Malaria_Homo sapiens_hsa051442.05133363
15Measles_Homo sapiens_hsa051622.04282546
16Pertussis_Homo sapiens_hsa051331.97607972
17Tuberculosis_Homo sapiens_hsa051521.97390899
18Influenza A_Homo sapiens_hsa051641.89586798
19African trypanosomiasis_Homo sapiens_hsa051431.88196688
20Asthma_Homo sapiens_hsa053101.82043066
21Staphylococcus aureus infection_Homo sapiens_hsa051501.75235224
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72357764
23Toxoplasmosis_Homo sapiens_hsa051451.64089844
24Apoptosis_Homo sapiens_hsa042101.57394481
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.53944272
26B cell receptor signaling pathway_Homo sapiens_hsa046621.50362334
27Chemokine signaling pathway_Homo sapiens_hsa040621.48737719
28Herpes simplex infection_Homo sapiens_hsa051681.43393597
29Phagosome_Homo sapiens_hsa041451.41977106
30Salmonella infection_Homo sapiens_hsa051321.40775481
31Other glycan degradation_Homo sapiens_hsa005111.38609363
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33891600
33Hematopoietic cell lineage_Homo sapiens_hsa046401.31089218
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28080936
35Type II diabetes mellitus_Homo sapiens_hsa049301.27984171
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.21206317
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20527164
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15297112
39Autoimmune thyroid disease_Homo sapiens_hsa053201.14601626
40Hepatitis B_Homo sapiens_hsa051611.13125732
41Shigellosis_Homo sapiens_hsa051311.10418020
42Prolactin signaling pathway_Homo sapiens_hsa049171.08742939
43Hepatitis C_Homo sapiens_hsa051601.05748188
44Lysosome_Homo sapiens_hsa041421.03220644
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99476299
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99256520
47T cell receptor signaling pathway_Homo sapiens_hsa046600.98840077
48Chronic myeloid leukemia_Homo sapiens_hsa052200.93772214
49Antigen processing and presentation_Homo sapiens_hsa046120.93708491
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92529336
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.91604393
52Viral myocarditis_Homo sapiens_hsa054160.89891695
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.87467449
54Bladder cancer_Homo sapiens_hsa052190.87439291
55Epstein-Barr virus infection_Homo sapiens_hsa051690.85653313
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83780375
57Circadian rhythm_Homo sapiens_hsa047100.81231102
58Amoebiasis_Homo sapiens_hsa051460.81072652
59Focal adhesion_Homo sapiens_hsa045100.80834384
60Sphingolipid metabolism_Homo sapiens_hsa006000.80024083
61Small cell lung cancer_Homo sapiens_hsa052220.79798803
62Pancreatic cancer_Homo sapiens_hsa052120.79160725
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78951108
64Bile secretion_Homo sapiens_hsa049760.78051088
65Acute myeloid leukemia_Homo sapiens_hsa052210.70608372
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69167541
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68292684
68Notch signaling pathway_Homo sapiens_hsa043300.67506561
69MicroRNAs in cancer_Homo sapiens_hsa052060.66064989
70GnRH signaling pathway_Homo sapiens_hsa049120.66061306
71FoxO signaling pathway_Homo sapiens_hsa040680.64613683
72Dilated cardiomyopathy_Homo sapiens_hsa054140.64317491
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63203456
74Dorso-ventral axis formation_Homo sapiens_hsa043200.62860526
75Insulin resistance_Homo sapiens_hsa049310.62667574
76Insulin signaling pathway_Homo sapiens_hsa049100.62639148
77Colorectal cancer_Homo sapiens_hsa052100.60253122
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58213353
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57413672
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.55415590
81Melanoma_Homo sapiens_hsa052180.55066522
82Collecting duct acid secretion_Homo sapiens_hsa049660.53945628
83Prion diseases_Homo sapiens_hsa050200.52965004
84Adherens junction_Homo sapiens_hsa045200.52954471
85Viral carcinogenesis_Homo sapiens_hsa052030.52002936
86Fatty acid biosynthesis_Homo sapiens_hsa000610.51660122
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51655076
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.50848315
89MAPK signaling pathway_Homo sapiens_hsa040100.50134157
90Ras signaling pathway_Homo sapiens_hsa040140.48612242
91Oxytocin signaling pathway_Homo sapiens_hsa049210.48574508
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48429256
93mTOR signaling pathway_Homo sapiens_hsa041500.48220404
94Prostate cancer_Homo sapiens_hsa052150.47072779
95Ovarian steroidogenesis_Homo sapiens_hsa049130.45524697
96Pathways in cancer_Homo sapiens_hsa052000.45404547
97HTLV-I infection_Homo sapiens_hsa051660.43887238
98Proteoglycans in cancer_Homo sapiens_hsa052050.42304191
99cAMP signaling pathway_Homo sapiens_hsa040240.40396441
100Rap1 signaling pathway_Homo sapiens_hsa040150.40118915
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.39823656
102Estrogen signaling pathway_Homo sapiens_hsa049150.39455790
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35473204
104ErbB signaling pathway_Homo sapiens_hsa040120.34485948
105Glioma_Homo sapiens_hsa052140.34420978
106Primary immunodeficiency_Homo sapiens_hsa053400.33797543
107Platelet activation_Homo sapiens_hsa046110.33608316
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.32882016
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32492988
110Non-small cell lung cancer_Homo sapiens_hsa052230.31916171
111HIF-1 signaling pathway_Homo sapiens_hsa040660.31897077
112Endometrial cancer_Homo sapiens_hsa052130.31439976
113p53 signaling pathway_Homo sapiens_hsa041150.31343160
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30140192
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28529992
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28138289
117Renal cell carcinoma_Homo sapiens_hsa052110.27833770
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27515502
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26533485
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26523007
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25943704
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25166900
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25146541
124Inositol phosphate metabolism_Homo sapiens_hsa005620.24893347
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23928584

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