ZC3H14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.41235364
2synaptonemal complex assembly (GO:0007130)5.87763562
3cilium or flagellum-dependent cell motility (GO:0001539)5.82941877
4male meiosis (GO:0007140)5.75408057
5synaptonemal complex organization (GO:0070193)5.69510357
6nuclear pore complex assembly (GO:0051292)5.20876099
7nuclear pore organization (GO:0006999)5.05548089
8fusion of sperm to egg plasma membrane (GO:0007342)4.85421395
9mitotic sister chromatid cohesion (GO:0007064)4.80529199
10acrosome assembly (GO:0001675)4.72512663
11binding of sperm to zona pellucida (GO:0007339)4.72297775
12sperm-egg recognition (GO:0035036)4.65771024
13gene silencing by RNA (GO:0031047)4.62414460
14monoubiquitinated protein deubiquitination (GO:0035520)4.61085100
15chromosome organization involved in meiosis (GO:0070192)4.42202307
16motile cilium assembly (GO:0044458)4.28596192
17axonemal dynein complex assembly (GO:0070286)4.28450686
18sperm motility (GO:0030317)4.20741887
19cell-cell recognition (GO:0009988)4.19239925
20DNA methylation involved in gamete generation (GO:0043046)4.18076660
21male meiosis I (GO:0007141)4.15582528
22spermatid development (GO:0007286)4.14158296
23meiotic nuclear division (GO:0007126)4.07353458
24mitotic chromosome condensation (GO:0007076)4.01699030
25regulation of histone H3-K9 methylation (GO:0051570)3.91812425
26regulation of RNA export from nucleus (GO:0046831)3.91501779
27DNA replication-dependent nucleosome organization (GO:0034723)3.76601661
28DNA replication-dependent nucleosome assembly (GO:0006335)3.76601661
29peptidyl-lysine dimethylation (GO:0018027)3.75010838
30heterochromatin organization (GO:0070828)3.73843425
31chromosome condensation (GO:0030261)3.66637178
32regulation of meiosis I (GO:0060631)3.66613529
33regulation of centriole replication (GO:0046599)3.65182828
34pore complex assembly (GO:0046931)3.60096737
35protein localization to chromosome, centromeric region (GO:0071459)3.58177586
36translesion synthesis (GO:0019985)3.57443936
37meiosis I (GO:0007127)3.54701504
38gene silencing (GO:0016458)3.52963802
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50650005
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50650005
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.50650005
42negative regulation of DNA repair (GO:0045738)3.48686816
43mitotic nuclear envelope disassembly (GO:0007077)3.47353076
44DNA packaging (GO:0006323)3.46764163
45plasma membrane fusion (GO:0045026)3.45900869
46chromatin assembly (GO:0031497)3.42822094
47regulation of sister chromatid cohesion (GO:0007063)3.41556897
48membrane disassembly (GO:0030397)3.34853446
49nuclear envelope disassembly (GO:0051081)3.34853446
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31344842
51sister chromatid cohesion (GO:0007062)3.29963697
52genitalia morphogenesis (GO:0035112)3.28505646
53meiotic cell cycle process (GO:1903046)3.28282772
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27071486
55protein localization to kinetochore (GO:0034501)3.27027154
56pre-miRNA processing (GO:0031054)3.26471115
57multicellular organism reproduction (GO:0032504)3.22881786
58COPI coating of Golgi vesicle (GO:0048205)3.22835964
59Golgi transport vesicle coating (GO:0048200)3.22835964
60seminiferous tubule development (GO:0072520)3.19594665
61DNA unwinding involved in DNA replication (GO:0006268)3.18497325
62synapsis (GO:0007129)3.16600457
63sister chromatid segregation (GO:0000819)3.15109537
64regulation of nucleobase-containing compound transport (GO:0032239)3.11645795
65chaperone-mediated protein complex assembly (GO:0051131)3.10954320
66negative regulation of histone methylation (GO:0031061)3.09619355
67dosage compensation (GO:0007549)3.09483225
68regulation of DNA endoreduplication (GO:0032875)3.08851121
69regulation of chromosome segregation (GO:0051983)3.06456102
70epithelial cilium movement (GO:0003351)3.02380460
71replication fork processing (GO:0031297)3.02192470
72regulation of centrosome cycle (GO:0046605)3.01892259
73histone exchange (GO:0043486)3.01173232
74RNA stabilization (GO:0043489)3.00327490
75mRNA stabilization (GO:0048255)3.00327490
76spliceosomal tri-snRNP complex assembly (GO:0000244)2.98465832
77meiotic cell cycle (GO:0051321)2.97391066
78protein localization to chromosome (GO:0034502)2.96818767
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96633077
80chromatin assembly or disassembly (GO:0006333)2.94152927
81histone H2A monoubiquitination (GO:0035518)2.93568152
82attachment of spindle microtubules to kinetochore (GO:0008608)2.92891105
83germ cell development (GO:0007281)2.91698646
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.89155480
85DNA double-strand break processing (GO:0000729)2.88451712
86regulation of cilium movement (GO:0003352)2.88089524
87male gamete generation (GO:0048232)2.87692555
88spermatogenesis (GO:0007283)2.87512511
89positive regulation of chromosome segregation (GO:0051984)2.87236879
90mitotic sister chromatid segregation (GO:0000070)2.87209411
91regulation of mitotic spindle checkpoint (GO:1903504)2.85560603
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85560603
93negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.84652042
94regulation of hippo signaling (GO:0035330)2.84376412
95regulation of centrosome duplication (GO:0010824)2.83700811
96folic acid-containing compound biosynthetic process (GO:0009396)2.83567019
97DNA conformation change (GO:0071103)2.83387185
98cell wall macromolecule metabolic process (GO:0044036)2.81838871
99cell wall macromolecule catabolic process (GO:0016998)2.81838871
100meiotic chromosome segregation (GO:0045132)2.80652349
101chromatin remodeling at centromere (GO:0031055)2.79202656
102DNA duplex unwinding (GO:0032508)2.77505848
103DNA geometric change (GO:0032392)2.76988847
104nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.75968044
105cellular process involved in reproduction in multicellular organism (GO:0022412)2.75963049
106behavioral response to nicotine (GO:0035095)2.75597896
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74166898
108mitotic metaphase plate congression (GO:0007080)2.74131566
109DNA synthesis involved in DNA repair (GO:0000731)2.74042632
110metaphase plate congression (GO:0051310)2.73166485
111ATP-dependent chromatin remodeling (GO:0043044)2.73002340
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71399359
113negative regulation of translation, ncRNA-mediated (GO:0040033)2.71399359
114regulation of translation, ncRNA-mediated (GO:0045974)2.71399359
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.70915461
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70915461
117CENP-A containing nucleosome assembly (GO:0034080)2.67730793
118regulation of posttranscriptional gene silencing (GO:0060147)2.67630359
119regulation of gene silencing by miRNA (GO:0060964)2.67630359
120regulation of gene silencing by RNA (GO:0060966)2.67630359
121reciprocal meiotic recombination (GO:0007131)2.64198809
122reciprocal DNA recombination (GO:0035825)2.64198809
123DNA replication checkpoint (GO:0000076)2.48396565
124resolution of meiotic recombination intermediates (GO:0000712)2.47606547
125presynaptic membrane assembly (GO:0097105)2.44849870
126recombinational repair (GO:0000725)2.44364991
127centriole replication (GO:0007099)2.43773045
128nonmotile primary cilium assembly (GO:0035058)2.43252955
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.41077687
130double-strand break repair via homologous recombination (GO:0000724)2.41003282
131double-strand break repair via nonhomologous end joining (GO:0006303)2.39728528
132non-recombinational repair (GO:0000726)2.39728528
133microtubule anchoring (GO:0034453)2.36158094
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35832917
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35120636
136postreplication repair (GO:0006301)2.31140162
137spindle checkpoint (GO:0031577)2.30721634
138kinetochore organization (GO:0051383)2.30185624
139rRNA catabolic process (GO:0016075)2.29743994
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.26481102
141histone H2A acetylation (GO:0043968)2.25360234
142negative regulation of DNA recombination (GO:0045910)2.25147003
143microtubule depolymerization (GO:0007019)2.25063252
144intraciliary transport (GO:0042073)2.24406333
145neural tube formation (GO:0001841)2.23542483
146ncRNA catabolic process (GO:0034661)2.23361581
147pyrimidine nucleobase catabolic process (GO:0006208)2.22027318
148photoreceptor cell maintenance (GO:0045494)2.21397299
149signal peptide processing (GO:0006465)2.19672798
150cilium morphogenesis (GO:0060271)2.19177351
151mitotic spindle checkpoint (GO:0071174)2.16408653
152DNA ligation (GO:0006266)2.16222180
153oxidative demethylation (GO:0070989)2.15803379
154pyrimidine dimer repair (GO:0006290)2.15472286
155dorsal/ventral axis specification (GO:0009950)2.14813632
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.14310286
157lysine catabolic process (GO:0006554)2.13022876
158lysine metabolic process (GO:0006553)2.13022876
159cilium organization (GO:0044782)2.12969638
160cilium assembly (GO:0042384)2.11771415
161protein prenylation (GO:0018342)2.10988644
162prenylation (GO:0097354)2.10988644
163telomere maintenance via telomerase (GO:0007004)2.10980573
164presynaptic membrane organization (GO:0097090)2.10848716
165protein K6-linked ubiquitination (GO:0085020)2.10419354
166DNA replication-independent nucleosome assembly (GO:0006336)2.10031926
167DNA replication-independent nucleosome organization (GO:0034724)2.10031926
168embryonic foregut morphogenesis (GO:0048617)2.09994286
169microtubule organizing center organization (GO:0031023)2.09364591
170protein polyglutamylation (GO:0018095)2.07580780
171cytoplasmic mRNA processing body assembly (GO:0033962)2.07232991
172response to X-ray (GO:0010165)2.06164500
173negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.05548101
174negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.05548101
175negative regulation of mitotic sister chromatid segregation (GO:0033048)2.05548101
176negative regulation of mitotic sister chromatid separation (GO:2000816)2.05548101
177negative regulation of sister chromatid segregation (GO:0033046)2.05548101
178negative regulation of chromosome segregation (GO:0051985)2.05431326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51803528
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.81277441
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.21285804
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67247917
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.24528402
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05502604
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.93855611
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.93545771
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.93242189
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84797481
11GBX2_23144817_ChIP-Seq_PC3_Human2.63467554
12AR_21909140_ChIP-Seq_LNCAP_Human2.63107468
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.58835627
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57487601
15EWS_26573619_Chip-Seq_HEK293_Human2.48544660
16IGF1R_20145208_ChIP-Seq_DFB_Human2.47615815
17VDR_22108803_ChIP-Seq_LS180_Human2.46817952
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.44901216
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42929591
20FUS_26573619_Chip-Seq_HEK293_Human2.41212060
21* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32120517
22TAF15_26573619_Chip-Seq_HEK293_Human2.29297493
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.26542575
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25025616
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19636346
26* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14474483
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14445629
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13262185
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95737064
30* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.94406683
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88820074
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88573664
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87754196
34MYC_22102868_ChIP-Seq_BL_Human1.87725778
35P300_19829295_ChIP-Seq_ESCs_Human1.87720571
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84087714
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82440926
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79964913
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78798201
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78495382
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74892388
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.74179828
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73803259
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67323409
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63671850
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60601798
47STAT3_23295773_ChIP-Seq_U87_Human1.57737574
48KDM5A_27292631_Chip-Seq_BREAST_Human1.56549802
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56446433
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54077488
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.54034799
52ZNF263_19887448_ChIP-Seq_K562_Human1.53934603
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52896902
54XRN2_22483619_ChIP-Seq_HELA_Human1.51851873
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.51519945
56ER_23166858_ChIP-Seq_MCF-7_Human1.50946755
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48488390
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45244038
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44325852
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43997383
61IRF1_19129219_ChIP-ChIP_H3396_Human1.43295743
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41850648
63CBP_20019798_ChIP-Seq_JUKART_Human1.41850648
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40923755
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40578355
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39537602
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37060305
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36997097
69GABP_19822575_ChIP-Seq_HepG2_Human1.35541395
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34984174
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34842982
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.34463061
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34252943
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32206510
75TCF4_23295773_ChIP-Seq_U87_Human1.31684867
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30749752
77EZH2_22144423_ChIP-Seq_EOC_Human1.30479996
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29416328
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28297017
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27854259
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26400793
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.25766127
83VDR_23849224_ChIP-Seq_CD4+_Human1.25117734
84MYC_18940864_ChIP-ChIP_HL60_Human1.24916429
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22997908
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22229257
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22218549
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21660416
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21263543
90CHD1_26751641_Chip-Seq_LNCaP_Human1.20075233
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19664202
92DCP1A_22483619_ChIP-Seq_HELA_Human1.18528924
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18219883
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17734540
95* AR_25329375_ChIP-Seq_VCAP_Human1.17009789
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16478300
97FOXP3_21729870_ChIP-Seq_TREG_Human1.16103194
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.15499895
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15132122
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14027402
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13745735
102TCF4_22108803_ChIP-Seq_LS180_Human1.13114297
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12948614
104TCF7_22412390_ChIP-Seq_EML_Mouse1.12611718
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12155639
106CIITA_25753668_ChIP-Seq_RAJI_Human1.11957184
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11556884
108RNF2_27304074_Chip-Seq_NSC_Mouse1.11542379
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10989808
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09231563
111SOX9_26525672_Chip-Seq_HEART_Mouse1.08214259
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07862519
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07112359
114TTF2_22483619_ChIP-Seq_HELA_Human1.06823617
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06667288
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05188678
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.04022465
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.02511362
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01927160
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01927160
121TP53_22573176_ChIP-Seq_HFKS_Human1.01803339
122BCAT_22108803_ChIP-Seq_LS180_Human1.01618125
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01219687
124TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00819187
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00187007
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00070426
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.99893663
128* RUNX2_22187159_ChIP-Seq_PCA_Human0.99047941
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98582194
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98423852
131ELK1_19687146_ChIP-ChIP_HELA_Human0.98320128
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96949683
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96218108
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95616060
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.95145539
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94903310
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94180625
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94015193
139* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93792868
140ETS1_20019798_ChIP-Seq_JURKAT_Human0.93540158
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93240694
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93143132
143JUN_21703547_ChIP-Seq_K562_Human0.92724571
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91307361
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91110354
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90284148
147TFEB_21752829_ChIP-Seq_HELA_Human0.89374043
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89108346
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88157363
150ZNF274_21170338_ChIP-Seq_K562_Hela0.87694407
151HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87067571
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86861566
153CLOCK_20551151_ChIP-Seq_293T_Human0.85792244
154E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85264555
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84656286
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83797809
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82385112
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80807449
159* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79723621
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78951063
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78452736
162MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.77246509
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75967471
164BRD4_25478319_ChIP-Seq_HGPS_Human0.75818222
165ATF3_27146783_Chip-Seq_COLON_Human0.75228819
166EST1_17652178_ChIP-ChIP_JURKAT_Human0.75170137
167FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74847289
168ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74054184
169GABP_17652178_ChIP-ChIP_JURKAT_Human0.71435830
170MYB_26560356_Chip-Seq_TH1_Human0.70779957
171TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70278813
172NCOR1_26117541_ChIP-Seq_K562_Human0.69367662
173STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69254489
174UBF1/2_26484160_Chip-Seq_HMECs_Human0.68152172
175ETS1_22383799_ChIP-Seq_G1ME_Mouse0.67873946
176SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.67145215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.16749003
2MP0008877_abnormal_DNA_methylation3.96668743
3MP0010094_abnormal_chromosome_stability3.04033481
4MP0003693_abnormal_embryo_hatching2.86690667
5MP0001929_abnormal_gametogenesis2.81267125
6MP0003123_paternal_imprinting2.76153033
7MP0004957_abnormal_blastocyst_morpholog2.68628767
8MP0003111_abnormal_nucleus_morphology2.67802391
9MP0008057_abnormal_DNA_replication2.55444099
10MP0008007_abnormal_cellular_replicative2.49762083
11MP0002210_abnormal_sex_determination2.49374269
12MP0003698_abnormal_male_reproductive2.39762254
13MP0003077_abnormal_cell_cycle2.37943375
14MP0010307_abnormal_tumor_latency2.22435547
15MP0002877_abnormal_melanocyte_morpholog2.19183586
16MP0010352_gastrointestinal_tract_polyps2.17796999
17MP0001145_abnormal_male_reproductive2.11760426
18MP0000537_abnormal_urethra_morphology2.05373990
19MP0003705_abnormal_hypodermis_morpholog2.03032745
20MP0000569_abnormal_digit_pigmentation2.02126069
21MP0008058_abnormal_DNA_repair1.95923712
22MP0001730_embryonic_growth_arrest1.95827362
23MP0005076_abnormal_cell_differentiation1.93634029
24MP0006054_spinal_hemorrhage1.88598369
25MP0000653_abnormal_sex_gland1.88445274
26MP0003718_maternal_effect1.87450191
27MP0002653_abnormal_ependyma_morphology1.85381546
28MP0003121_genomic_imprinting1.81730724
29MP0010234_abnormal_vibrissa_follicle1.73120044
30MP0000427_abnormal_hair_cycle1.69118371
31MP0002084_abnormal_developmental_patter1.67674964
32MP0005623_abnormal_meninges_morphology1.64663143
33MP0001697_abnormal_embryo_size1.61646973
34MP0003890_abnormal_embryonic-extraembry1.59995962
35MP0001672_abnormal_embryogenesis/_devel1.57835807
36MP0005380_embryogenesis_phenotype1.57835807
37MP0003195_calcinosis1.57783881
38MP0004808_abnormal_hematopoietic_stem1.55298198
39MP0004197_abnormal_fetal_growth/weight/1.55054603
40MP0004233_abnormal_muscle_weight1.54204198
41MP0006072_abnormal_retinal_apoptosis1.52383602
42MP0003984_embryonic_growth_retardation1.52224458
43MP0000350_abnormal_cell_proliferation1.52011278
44MP0002102_abnormal_ear_morphology1.51457982
45MP0002088_abnormal_embryonic_growth/wei1.50168768
46MP0000383_abnormal_hair_follicle1.49604674
47MP0003786_premature_aging1.47855134
48MP0002161_abnormal_fertility/fecundity1.44069272
49MP0001529_abnormal_vocalization1.42080054
50MP0005551_abnormal_eye_electrophysiolog1.41957826
51MP0002086_abnormal_extraembryonic_tissu1.41815538
52MP0002085_abnormal_embryonic_tissue1.41533429
53MP0002234_abnormal_pharynx_morphology1.39391501
54MP0009053_abnormal_anal_canal1.37810979
55MP0006292_abnormal_olfactory_placode1.36377451
56MP0003880_abnormal_central_pattern1.33509916
57MP0002080_prenatal_lethality1.31496884
58MP0002160_abnormal_reproductive_system1.29804918
59MP0005253_abnormal_eye_physiology1.29317532
60MP0009672_abnormal_birth_weight1.28060452
61MP0000647_abnormal_sebaceous_gland1.27496375
62MP0001984_abnormal_olfaction1.26890288
63MP0000778_abnormal_nervous_system1.25434538
64MP0003567_abnormal_fetal_cardiomyocyte1.21439741
65MP0002233_abnormal_nose_morphology1.21148121
66MP0009697_abnormal_copulation1.20327449
67MP0004147_increased_porphyrin_level1.20168618
68MP0009046_muscle_twitch1.18845990
69MP0003115_abnormal_respiratory_system1.18568564
70MP0003941_abnormal_skin_development1.17847072
71MP0010030_abnormal_orbit_morphology1.16128327
72MP0000631_abnormal_neuroendocrine_gland1.15205755
73MP0003136_yellow_coat_color1.14570591
74MP0002638_abnormal_pupillary_reflex1.14474307
75MP0009703_decreased_birth_body1.13039749
76MP0006276_abnormal_autonomic_nervous1.12015808
77MP0010678_abnormal_skin_adnexa1.11785485
78MP0008932_abnormal_embryonic_tissue1.11458488
79MP0001293_anophthalmia1.09875628
80MP0001849_ear_inflammation1.09697329
81MP0008995_early_reproductive_senescence1.08451422
82MP0003943_abnormal_hepatobiliary_system1.08341219
83MP0004264_abnormal_extraembryonic_tissu1.07328323
84MP0002928_abnormal_bile_duct1.04572139
85MP0005187_abnormal_penis_morphology1.04455809
86MP0002751_abnormal_autonomic_nervous1.03332994
87MP0004133_heterotaxia1.02875881
88MP0003119_abnormal_digestive_system1.02282719
89MP0001299_abnormal_eye_distance/1.00951793
90MP0000733_abnormal_muscle_development0.99826762
91MP0005646_abnormal_pituitary_gland0.99796658
92MP0003861_abnormal_nervous_system0.98887447
93MP0001286_abnormal_eye_development0.98599942
94MP0000428_abnormal_craniofacial_morphol0.98093458
95MP0002092_abnormal_eye_morphology0.97486775
96MP0001486_abnormal_startle_reflex0.96267364
97MP0000313_abnormal_cell_death0.95790300
98MP0003221_abnormal_cardiomyocyte_apopto0.95554372
99MP0005389_reproductive_system_phenotype0.94918642
100MP0005391_vision/eye_phenotype0.94669272
101MP0003300_gastrointestinal_ulcer0.93832660
102MP0004043_abnormal_pH_regulation0.93113951
103MP0002184_abnormal_innervation0.91359267
104MP0003755_abnormal_palate_morphology0.91306561
105MP0001348_abnormal_lacrimal_gland0.90167028
106MP0002282_abnormal_trachea_morphology0.88347431
107MP0001915_intracranial_hemorrhage0.87963864
108MP0002837_dystrophic_cardiac_calcinosis0.87690512
109MP0004215_abnormal_myocardial_fiber0.86376073
110MP0005220_abnormal_exocrine_pancreas0.86122618
111MP0002697_abnormal_eye_size0.85741884
112MP0001485_abnormal_pinna_reflex0.84271239
113MP0001177_atelectasis0.83556230
114MP0002009_preneoplasia0.83542390
115MP0003937_abnormal_limbs/digits/tail_de0.83541722
116MP0000955_abnormal_spinal_cord0.83427080
117MP0002557_abnormal_social/conspecific_i0.83103972
118MP0002736_abnormal_nociception_after0.82713026
119MP0005386_behavior/neurological_phenoty0.82525032
120MP0004924_abnormal_behavior0.82525032
121MP0002396_abnormal_hematopoietic_system0.82383669
122MP0001119_abnormal_female_reproductive0.82341695
123MP0003935_abnormal_craniofacial_develop0.81942211
124MP0002019_abnormal_tumor_incidence0.81921181
125MP0003942_abnormal_urinary_system0.80956143
126MP0004142_abnormal_muscle_tone0.80942187
127MP0002272_abnormal_nervous_system0.80817112
128MP0003787_abnormal_imprinting0.79403436
129MP0000566_synostosis0.78455720
130MP0003385_abnormal_body_wall0.76664177
131MP0001944_abnormal_pancreas_morphology0.74928240
132MP0002090_abnormal_vision0.74896630
133MP0002925_abnormal_cardiovascular_devel0.73185462
134MP0001545_abnormal_hematopoietic_system0.72296773
135MP0005397_hematopoietic_system_phenotyp0.72296773
136MP0005645_abnormal_hypothalamus_physiol0.72153692
137MP0003283_abnormal_digestive_organ0.71942233
138MP0009745_abnormal_behavioral_response0.71558766
139MP0000490_abnormal_crypts_of0.71132397
140MP0005395_other_phenotype0.71097660
141MP0002752_abnormal_somatic_nervous0.70718016
142MP0000534_abnormal_ureter_morphology0.70650558
143MP0002735_abnormal_chemical_nociception0.70494011
144MP0003566_abnormal_cell_adhesion0.69730121
145MP0010630_abnormal_cardiac_muscle0.69080582
146MP0000266_abnormal_heart_morphology0.68338059
147MP0003252_abnormal_bile_duct0.68089242
148MP0003122_maternal_imprinting0.67457782
149MP0000371_diluted_coat_color0.66947914
150MP0000358_abnormal_cell_content/0.66153069
151MP0004084_abnormal_cardiac_muscle0.63673904
152MP0003699_abnormal_female_reproductive0.63597582
153MP0002938_white_spotting0.63083187
154MP0005367_renal/urinary_system_phenotyp0.63031026
155MP0000516_abnormal_urinary_system0.63031026
156MP0003315_abnormal_perineum_morphology0.62850875

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.72757021
2Absent/shortened dynein arms (HP:0200106)5.72757021
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.40263058
4Abnormal respiratory motile cilium physiology (HP:0012261)4.00170731
5Nasal polyposis (HP:0100582)3.93887214
6Abnormal respiratory epithelium morphology (HP:0012253)3.60654200
7Abnormal respiratory motile cilium morphology (HP:0005938)3.60654200
8Chronic bronchitis (HP:0004469)3.60450812
9Abnormality of the lower motor neuron (HP:0002366)3.59365069
10Infertility (HP:0000789)3.47381862
11Papillary thyroid carcinoma (HP:0002895)3.30840397
12Abnormality of the nasal mucosa (HP:0000433)3.24280477
13Rhinitis (HP:0012384)3.13526222
14Pancreatic cysts (HP:0001737)3.10585038
15Abnormal spermatogenesis (HP:0008669)3.02097920
16Pancreatic fibrosis (HP:0100732)2.93051174
17Abnormal ciliary motility (HP:0012262)2.90516043
18Molar tooth sign on MRI (HP:0002419)2.86318908
19Abnormality of midbrain morphology (HP:0002418)2.86318908
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82507278
2111 pairs of ribs (HP:0000878)2.80034001
22Abnormality of the labia minora (HP:0012880)2.79541538
23Selective tooth agenesis (HP:0001592)2.78805069
24Chromsome breakage (HP:0040012)2.76472698
25Gonadotropin excess (HP:0000837)2.74611256
26Abnormality of alanine metabolism (HP:0010916)2.73066677
27Hyperalaninemia (HP:0003348)2.73066677
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73066677
29Volvulus (HP:0002580)2.71336724
30Abnormality of the anterior horn cell (HP:0006802)2.69896487
31Degeneration of anterior horn cells (HP:0002398)2.69896487
32Medial flaring of the eyebrow (HP:0010747)2.69799315
33Subacute progressive viral hepatitis (HP:0006572)2.64047487
34Chronic hepatic failure (HP:0100626)2.62476228
35True hermaphroditism (HP:0010459)2.61542956
36Missing ribs (HP:0000921)2.56287045
37Male infertility (HP:0003251)2.53605028
38Amyotrophic lateral sclerosis (HP:0007354)2.52717472
39Gait imbalance (HP:0002141)2.48877257
40Congenital primary aphakia (HP:0007707)2.47543016
41Azoospermia (HP:0000027)2.46091035
42Fibular hypoplasia (HP:0003038)2.44799920
43Hyperventilation (HP:0002883)2.43195686
44Nephronophthisis (HP:0000090)2.41013585
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.37424975
46Bronchiectasis (HP:0002110)2.36074755
47Renovascular hypertension (HP:0100817)2.34744976
48High pitched voice (HP:0001620)2.33556055
49Abnormality of the renal cortex (HP:0011035)2.33154823
50Birth length less than 3rd percentile (HP:0003561)2.32953780
51Meckel diverticulum (HP:0002245)2.32418161
52Increased nuchal translucency (HP:0010880)2.30630162
53Colon cancer (HP:0003003)2.30306006
54Breast carcinoma (HP:0003002)2.29564427
55Bronchitis (HP:0012387)2.29122844
56Heterotopia (HP:0002282)2.29086717
57Genital tract atresia (HP:0001827)2.29004306
58Vaginal atresia (HP:0000148)2.26817962
59Abnormality of the ileum (HP:0001549)2.25777468
60Nephrogenic diabetes insipidus (HP:0009806)2.25532206
61Glioma (HP:0009733)2.24059551
62Truncal obesity (HP:0001956)2.23828165
63Rectal prolapse (HP:0002035)2.22124188
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.21665565
65Poor coordination (HP:0002370)2.15733642
66Absent frontal sinuses (HP:0002688)2.13662915
67Renal duplication (HP:0000075)2.13620978
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.12734120
69Enlarged penis (HP:0000040)2.11695284
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10419310
71Short 4th metacarpal (HP:0010044)2.10419310
72Preaxial hand polydactyly (HP:0001177)2.09358930
73Absent radius (HP:0003974)2.09265001
74Protruding tongue (HP:0010808)2.07634530
75Hyperacusis (HP:0010780)2.06458433
76Biliary tract neoplasm (HP:0100574)2.05976149
77Aplasia involving forearm bones (HP:0009822)2.05884977
78Absent forearm bone (HP:0003953)2.05884977
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.04558760
80Lissencephaly (HP:0001339)2.03946812
81Patellar aplasia (HP:0006443)2.03772915
82Prominent nose (HP:0000448)2.03096292
83Impulsivity (HP:0100710)2.02890424
84Ectopic kidney (HP:0000086)2.02031431
85Oligodactyly (hands) (HP:0001180)2.01285113
86Cutaneous melanoma (HP:0012056)1.98081146
87Ependymoma (HP:0002888)1.97347374
88Abnormality of the fingertips (HP:0001211)1.97164786
89Overlapping toe (HP:0001845)1.96024651
90Dislocated radial head (HP:0003083)1.94510706
91Intestinal atresia (HP:0011100)1.94337582
92Ankle contracture (HP:0006466)1.94207994
93Thyroid carcinoma (HP:0002890)1.93745833
94Facial cleft (HP:0002006)1.92984746
95Abnormality of chromosome stability (HP:0003220)1.92846261
96Postaxial foot polydactyly (HP:0001830)1.91092266
97Astrocytoma (HP:0009592)1.90500112
98Abnormality of the astrocytes (HP:0100707)1.90500112
99Sandal gap (HP:0001852)1.90105349
100Cystic liver disease (HP:0006706)1.89702809
101Deviation of the thumb (HP:0009603)1.88732626
102Gaze-evoked nystagmus (HP:0000640)1.88160859
103Broad palm (HP:0001169)1.87659971
104Type II lissencephaly (HP:0007260)1.85868955
105Genetic anticipation (HP:0003743)1.85142642
106Bifid tongue (HP:0010297)1.84678036
107Hepatoblastoma (HP:0002884)1.83756675
108Sclerocornea (HP:0000647)1.83390868
109Abnormality of the renal medulla (HP:0100957)1.83090745
110Astigmatism (HP:0000483)1.82748057
111Aplasia/Hypoplasia of the patella (HP:0006498)1.82449172
112Drooling (HP:0002307)1.81864701
113Abnormality of the radial head (HP:0003995)1.81609371
114Macroorchidism (HP:0000053)1.81403221
115Hypoplastic labia majora (HP:0000059)1.80955474
116Microglossia (HP:0000171)1.80082666
117Rhizomelia (HP:0008905)1.79937299
118Abnormality of the 4th metacarpal (HP:0010012)1.79403569
119Proximal placement of thumb (HP:0009623)1.79340999
120Broad foot (HP:0001769)1.79135458
121Dandy-Walker malformation (HP:0001305)1.78772759
122Shoulder girdle muscle weakness (HP:0003547)1.78532216
123Acute myeloid leukemia (HP:0004808)1.78235385
124Abnormality of the carotid arteries (HP:0005344)1.77905121
125Abnormal pancreas size (HP:0012094)1.77076783
126Cerebellar dysplasia (HP:0007033)1.76420486
127Abnormality of the preputium (HP:0100587)1.76397353
128Hypopigmentation of the fundus (HP:0007894)1.75436669
129Nephroblastoma (Wilms tumor) (HP:0002667)1.75265803
130Medulloblastoma (HP:0002885)1.75177163
131Micronodular cirrhosis (HP:0001413)1.74884082
132Fair hair (HP:0002286)1.74799121
133Small hand (HP:0200055)1.74717137
134Small intestinal stenosis (HP:0012848)1.74182404
135Duodenal stenosis (HP:0100867)1.74182404
136Abnormality of the duodenum (HP:0002246)1.73783303
137Anencephaly (HP:0002323)1.73429898
138Tubulointerstitial nephritis (HP:0001970)1.72501500
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.72382259
140Short ribs (HP:0000773)1.72240197
141Renal cortical cysts (HP:0000803)1.71967782
142Facial hemangioma (HP:0000329)1.71542537
143Protrusio acetabuli (HP:0003179)1.71420286
144Aqueductal stenosis (HP:0002410)1.71221944
145Hand muscle atrophy (HP:0009130)1.71030440
146Postaxial hand polydactyly (HP:0001162)1.70920810
147Hyperglycinemia (HP:0002154)1.70687316
148Rhabdomyosarcoma (HP:0002859)1.70379362
149Bile duct proliferation (HP:0001408)1.70302241
150Abnormal biliary tract physiology (HP:0012439)1.70302241
151Tubular atrophy (HP:0000092)1.70276261
152Abnormality of serum amino acid levels (HP:0003112)1.70099021
153Embryonal renal neoplasm (HP:0011794)1.69616734
154Pelvic girdle muscle weakness (HP:0003749)1.68604229
155Ovarian neoplasm (HP:0100615)1.67519708
156Hyperglycinuria (HP:0003108)1.67162558
157Bowel diverticulosis (HP:0005222)1.66491036
158Abnormality of DNA repair (HP:0003254)1.66189959
159Triphalangeal thumb (HP:0001199)1.65126949
160Supernumerary spleens (HP:0009799)1.64815328
161Neoplasm of the adrenal cortex (HP:0100641)1.64813587
162Abnormality of the pons (HP:0007361)1.64692416
163Abnormal biliary tract morphology (HP:0012440)1.64171077
164Congenital stationary night blindness (HP:0007642)1.62862091
165Preaxial foot polydactyly (HP:0001841)1.62622420
166Progressive cerebellar ataxia (HP:0002073)1.62267203
167Hypoplasia of the pons (HP:0012110)1.62187815
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.62117903
169Abnormality of the labia majora (HP:0012881)1.61807913
170Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61741510
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61707239
172Micropenis (HP:0000054)1.60938260
173Upper motor neuron abnormality (HP:0002127)1.60753623
174Sloping forehead (HP:0000340)1.60687002
175Intestinal polyp (HP:0005266)1.60374945
176Abolished electroretinogram (ERG) (HP:0000550)1.60100548
177Elfin facies (HP:0004428)1.59601047
178Intestinal polyposis (HP:0200008)1.58152151
179Optic nerve hypoplasia (HP:0000609)1.57106392
180Progressive inability to walk (HP:0002505)1.56940966
181Pheochromocytoma (HP:0002666)1.56855338
182Chorioretinal atrophy (HP:0000533)1.56531834
183Short foot (HP:0001773)1.54452833
184Aplasia/Hypoplasia of the sternum (HP:0006714)1.53652954
185Proximal tubulopathy (HP:0000114)1.53613554
186Clubbing of toes (HP:0100760)1.53259560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.59734621
2PDK34.59734621
3CDC73.82891179
4PKN23.09818264
5NEK22.99555112
6PRKD32.95441409
7LATS12.61088951
8CDK122.58826961
9BMPR1B2.40071510
10EEF2K2.39768044
11TRIB32.35740232
12PASK2.35376105
13WEE12.31755969
14PDK22.29840610
15ACVR1B2.20086782
16SCYL22.02686826
17TESK11.99142227
18MAP3K41.89670597
19CASK1.89127881
20TRIM281.87832122
21STK31.81987019
22FRK1.79833014
23NUAK11.74293134
24MAP3K101.71026451
25STK391.66677229
26BCR1.54620977
27BRSK21.54413465
28TTK1.46584861
29ICK1.39348243
30FLT31.38719731
31AKT31.37634769
32DYRK31.35179165
33ATR1.33396241
34RPS6KA41.31265615
35NEK11.31119358
36FGFR21.29169646
37CDK91.24669027
38MARK11.23820194
39PDGFRA1.21854251
40TGFBR11.21363056
41GRK11.21224776
42OXSR11.18036775
43PLK11.17795704
44CDK61.17214275
45PBK1.17080622
46CHEK11.15385482
47CAMK1G1.14989299
48MAP2K71.13387772
49BRD41.11007635
50CDK41.10771395
51AURKB1.06359249
52MTOR1.05545036
53CHEK21.05489545
54PAK41.03559151
55PINK11.00739536
56PTK61.00704545
57EPHA40.99132146
58CSNK1A1L0.98398991
59TNIK0.98355407
60ATM0.97793031
61CSNK1G10.97090506
62MAPK130.94971802
63TTN0.94940103
64VRK10.94253203
65MKNK20.92327915
66PLK20.91886151
67RPS6KB20.91138325
68CSNK1G20.87520094
69DYRK1B0.86626021
70ADRBK20.85952455
71MKNK10.85895134
72STK38L0.84865621
73PAK30.82581750
74INSRR0.81687001
75CSNK1G30.80881866
76PIK3CA0.80206988
77CDK70.78961568
78LATS20.78168189
79RIPK10.78067179
80MST40.77899051
81MET0.77200729
82FER0.76930368
83PLK30.75533186
84MAP3K80.73730397
85PRKCE0.73681597
86SRPK10.72001707
87PTK2B0.71604657
88TYRO30.71480624
89TAF10.70484246
90MAP4K20.69359186
91STK160.69347845
92CDK20.67351318
93PLK40.66563860
94ERBB40.64949130
95MELK0.63229340
96BRSK10.63203973
97TLK10.62367200
98PAK20.61760024
99DYRK20.61686581
100WNK30.60657193
101FGFR10.60622480
102PRKCG0.59024204
103EIF2AK10.58298400
104NTRK30.57479738
105STK100.56226957
106NEK90.56188553
107STK40.56055235
108CSNK1E0.53358113
109NEK60.52771723
110ALK0.52581993
111STK380.51713677
112LRRK20.50649063
113CDK10.49478441
114DDR20.49201966
115WNK40.48985405
116EIF2AK20.48066016
117PDGFRB0.46246667
118CDK30.43541833
119KSR10.42832264
120ERBB30.41426883
121BUB10.41141884
122RET0.39526759
123PRKDC0.38679433
124DYRK1A0.38461583
125MINK10.37467953
126CDK80.37176755
127CDK190.36531514
128PRKCI0.35896632
129AURKA0.35750434
130CAMK2A0.35024037
131PNCK0.34117604
132WNK10.33224621
133ILK0.32960259
134RPS6KA50.32677530
135PRKACB0.32367283
136RPS6KB10.31644007
137CSNK1A10.30604556
138GSK3B0.30408326
139MAP3K20.30170152
140PRKAA10.29692819
141MAPK140.29505611
142PTK20.29449715
143CCNB10.29076673
144PIM10.28029635
145MAPK110.27992848
146CAMK1D0.27566177
147AKT10.27539522
148CSNK1D0.27344093
149EIF2AK30.27000491
150ZAK0.25717667
151MAP3K50.25539275
152PDK10.25510256
153TSSK60.24129984
154CHUK0.23958471

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030133.10136217
2DNA replication_Homo sapiens_hsa030303.09797227
3Cell cycle_Homo sapiens_hsa041103.02365039
4mRNA surveillance pathway_Homo sapiens_hsa030152.59744335
5Mismatch repair_Homo sapiens_hsa034302.41130070
6Selenocompound metabolism_Homo sapiens_hsa004502.34331996
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.31288972
8Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.14477625
9Spliceosome_Homo sapiens_hsa030402.13987011
10Basal transcription factors_Homo sapiens_hsa030222.13776278
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10407263
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04338609
13Fanconi anemia pathway_Homo sapiens_hsa034601.96952979
14Butanoate metabolism_Homo sapiens_hsa006501.92105270
15Oocyte meiosis_Homo sapiens_hsa041141.89913585
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85202755
17Nucleotide excision repair_Homo sapiens_hsa034201.85187928
18One carbon pool by folate_Homo sapiens_hsa006701.79911712
19Glucagon signaling pathway_Homo sapiens_hsa049221.72684755
20RNA degradation_Homo sapiens_hsa030181.70320641
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69611387
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65481964
23Base excision repair_Homo sapiens_hsa034101.65009937
24Systemic lupus erythematosus_Homo sapiens_hsa053221.64212068
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64188257
26Homologous recombination_Homo sapiens_hsa034401.62330216
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59172708
28p53 signaling pathway_Homo sapiens_hsa041151.50287062
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48476310
30Nicotine addiction_Homo sapiens_hsa050331.46236772
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.44201325
32Viral carcinogenesis_Homo sapiens_hsa052031.44190375
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41170511
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35647706
35Dorso-ventral axis formation_Homo sapiens_hsa043201.33555099
36Steroid biosynthesis_Homo sapiens_hsa001001.33152805
37Non-homologous end-joining_Homo sapiens_hsa034501.31160710
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.30559052
39Lysine degradation_Homo sapiens_hsa003101.30521677
40Thyroid cancer_Homo sapiens_hsa052161.29628811
41Tryptophan metabolism_Homo sapiens_hsa003801.27649335
42Pyruvate metabolism_Homo sapiens_hsa006201.25230458
43Nitrogen metabolism_Homo sapiens_hsa009101.25083889
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25062968
45Phototransduction_Homo sapiens_hsa047441.24860689
46Pentose phosphate pathway_Homo sapiens_hsa000301.23704539
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.22108956
48Antigen processing and presentation_Homo sapiens_hsa046121.21634310
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19299860
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18453518
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16837763
52Small cell lung cancer_Homo sapiens_hsa052221.16307758
53N-Glycan biosynthesis_Homo sapiens_hsa005101.16238668
54Adherens junction_Homo sapiens_hsa045201.15872391
55Biosynthesis of amino acids_Homo sapiens_hsa012301.12400211
56mTOR signaling pathway_Homo sapiens_hsa041501.10454132
57beta-Alanine metabolism_Homo sapiens_hsa004101.07755226
58HTLV-I infection_Homo sapiens_hsa051661.07384490
59Endometrial cancer_Homo sapiens_hsa052131.05014884
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04550787
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04347254
62MicroRNAs in cancer_Homo sapiens_hsa052061.04112445
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03911976
64Linoleic acid metabolism_Homo sapiens_hsa005911.01114652
65Hippo signaling pathway_Homo sapiens_hsa043900.96847404
66Alcoholism_Homo sapiens_hsa050340.96513885
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.96073451
68Proteasome_Homo sapiens_hsa030500.96008009
69Peroxisome_Homo sapiens_hsa041460.93832744
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93159219
71Carbon metabolism_Homo sapiens_hsa012000.93119046
72Pyrimidine metabolism_Homo sapiens_hsa002400.91752238
73Chronic myeloid leukemia_Homo sapiens_hsa052200.91130916
74TGF-beta signaling pathway_Homo sapiens_hsa043500.89875373
75AMPK signaling pathway_Homo sapiens_hsa041520.87372273
76Insulin signaling pathway_Homo sapiens_hsa049100.87351494
77Colorectal cancer_Homo sapiens_hsa052100.85387095
78Caffeine metabolism_Homo sapiens_hsa002320.84778384
79Taste transduction_Homo sapiens_hsa047420.84349396
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.80695895
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78864930
82Ether lipid metabolism_Homo sapiens_hsa005650.77537542
83Retinol metabolism_Homo sapiens_hsa008300.77293965
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76852771
85Vitamin B6 metabolism_Homo sapiens_hsa007500.76804133
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76755768
87Non-small cell lung cancer_Homo sapiens_hsa052230.75077645
88Herpes simplex infection_Homo sapiens_hsa051680.74936976
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72953990
90Prostate cancer_Homo sapiens_hsa052150.71355290
91Insulin resistance_Homo sapiens_hsa049310.70878806
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70854208
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70493506
94Histidine metabolism_Homo sapiens_hsa003400.69623434
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69396001
96Bladder cancer_Homo sapiens_hsa052190.68913518
97Focal adhesion_Homo sapiens_hsa045100.67943624
98Pancreatic cancer_Homo sapiens_hsa052120.66924382
99Chemical carcinogenesis_Homo sapiens_hsa052040.66376013
100Fatty acid metabolism_Homo sapiens_hsa012120.65937670
101Propanoate metabolism_Homo sapiens_hsa006400.65572076
102Estrogen signaling pathway_Homo sapiens_hsa049150.65435519
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65028053
104ABC transporters_Homo sapiens_hsa020100.64668180
105Folate biosynthesis_Homo sapiens_hsa007900.64603840
106Purine metabolism_Homo sapiens_hsa002300.64273615
107Huntingtons disease_Homo sapiens_hsa050160.63877585
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63871067
109Glutamatergic synapse_Homo sapiens_hsa047240.62570600
110Epstein-Barr virus infection_Homo sapiens_hsa051690.62375326
111Proteoglycans in cancer_Homo sapiens_hsa052050.61658296
112RNA polymerase_Homo sapiens_hsa030200.61377922
113Basal cell carcinoma_Homo sapiens_hsa052170.60482835
114FoxO signaling pathway_Homo sapiens_hsa040680.60462643
115Wnt signaling pathway_Homo sapiens_hsa043100.59788186
116GABAergic synapse_Homo sapiens_hsa047270.58229785
117Metabolic pathways_Homo sapiens_hsa011000.58147699
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58057668
119Fatty acid biosynthesis_Homo sapiens_hsa000610.57376159
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57212722
121Prolactin signaling pathway_Homo sapiens_hsa049170.56876411
122Olfactory transduction_Homo sapiens_hsa047400.55976387
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55765518
124Oxidative phosphorylation_Homo sapiens_hsa001900.55307582
125Arginine biosynthesis_Homo sapiens_hsa002200.52874639
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51699889
127Regulation of autophagy_Homo sapiens_hsa041400.51366778
128Tight junction_Homo sapiens_hsa045300.50572590
129Insulin secretion_Homo sapiens_hsa049110.49056114
130Glioma_Homo sapiens_hsa052140.47837635
131Arginine and proline metabolism_Homo sapiens_hsa003300.46929997
132Dopaminergic synapse_Homo sapiens_hsa047280.46350405
133Serotonergic synapse_Homo sapiens_hsa047260.45979308
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44986415
135Circadian entrainment_Homo sapiens_hsa047130.43680042
136Vitamin digestion and absorption_Homo sapiens_hsa049770.42817028
137Fat digestion and absorption_Homo sapiens_hsa049750.41572088
138Fatty acid elongation_Homo sapiens_hsa000620.41485408
139Glycerolipid metabolism_Homo sapiens_hsa005610.41350124
140Hepatitis B_Homo sapiens_hsa051610.41067692
141Hedgehog signaling pathway_Homo sapiens_hsa043400.40620583
142HIF-1 signaling pathway_Homo sapiens_hsa040660.39584618
143VEGF signaling pathway_Homo sapiens_hsa043700.37222911
144ECM-receptor interaction_Homo sapiens_hsa045120.37010859
145Pathways in cancer_Homo sapiens_hsa052000.36780376
146Thyroid hormone synthesis_Homo sapiens_hsa049180.36645638
147Legionellosis_Homo sapiens_hsa051340.36382615
148Circadian rhythm_Homo sapiens_hsa047100.34683968
149Protein digestion and absorption_Homo sapiens_hsa049740.33348842
150Acute myeloid leukemia_Homo sapiens_hsa052210.32905308
151Notch signaling pathway_Homo sapiens_hsa043300.32622731
152Protein export_Homo sapiens_hsa030600.32244892
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31634923
154Fatty acid degradation_Homo sapiens_hsa000710.29547841
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28421652
156Type II diabetes mellitus_Homo sapiens_hsa049300.28175543
157Viral myocarditis_Homo sapiens_hsa054160.27234026
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.27090568

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »