ZC3H15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.70575150
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56264894
3CENP-A containing nucleosome assembly (GO:0034080)4.55483062
4mitotic metaphase plate congression (GO:0007080)4.54579245
5chromatin remodeling at centromere (GO:0031055)4.51881792
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.22699051
7protein localization to kinetochore (GO:0034501)4.21981763
8DNA replication-independent nucleosome assembly (GO:0006336)4.20005059
9DNA replication-independent nucleosome organization (GO:0034724)4.20005059
10ribosome assembly (GO:0042255)4.07953546
11nuclear pore organization (GO:0006999)4.00902771
12histone exchange (GO:0043486)4.00843859
13kinetochore organization (GO:0051383)3.94938354
14metaphase plate congression (GO:0051310)3.94888073
15formation of translation preinitiation complex (GO:0001731)3.92395101
16synapsis (GO:0007129)3.90266191
17DNA unwinding involved in DNA replication (GO:0006268)3.90244784
18maturation of SSU-rRNA (GO:0030490)3.77595475
19DNA ligation (GO:0006266)3.75862153
20ATP synthesis coupled proton transport (GO:0015986)3.73016085
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73016085
22chaperone-mediated protein transport (GO:0072321)3.67779437
23DNA replication checkpoint (GO:0000076)3.66518166
24protein localization to chromosome, centromeric region (GO:0071459)3.64022686
25DNA replication initiation (GO:0006270)3.60023165
26mitotic nuclear envelope disassembly (GO:0007077)3.58524509
27mitotic sister chromatid cohesion (GO:0007064)3.58009649
28kinetochore assembly (GO:0051382)3.57917071
29nuclear pore complex assembly (GO:0051292)3.57587244
30attachment of spindle microtubules to kinetochore (GO:0008608)3.57041852
31purine nucleobase biosynthetic process (GO:0009113)3.53450488
32spindle checkpoint (GO:0031577)3.53203692
33mitotic spindle checkpoint (GO:0071174)3.51440049
34DNA replication-dependent nucleosome organization (GO:0034723)3.50398534
35DNA replication-dependent nucleosome assembly (GO:0006335)3.50398534
36DNA damage response, detection of DNA damage (GO:0042769)3.48931295
37DNA strand elongation involved in DNA replication (GO:0006271)3.48188870
38ribosome biogenesis (GO:0042254)3.46365034
39nucleobase biosynthetic process (GO:0046112)3.46171690
40nuclear envelope disassembly (GO:0051081)3.43567825
41membrane disassembly (GO:0030397)3.43567825
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42890605
43establishment of chromosome localization (GO:0051303)3.41183187
44mitotic chromosome condensation (GO:0007076)3.40476132
45regulation of centriole replication (GO:0046599)3.39632634
46establishment of integrated proviral latency (GO:0075713)3.37182708
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36701642
48regulation of DNA endoreduplication (GO:0032875)3.35491913
49regulation of mitotic spindle checkpoint (GO:1903504)3.35041847
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35041847
51DNA strand elongation (GO:0022616)3.32494763
52regulation of RNA export from nucleus (GO:0046831)3.31096136
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30095081
54mitotic sister chromatid segregation (GO:0000070)3.28457437
55termination of RNA polymerase II transcription (GO:0006369)3.28402339
56spliceosomal snRNP assembly (GO:0000387)3.27614656
57regulation of centrosome cycle (GO:0046605)3.27173668
58folic acid-containing compound biosynthetic process (GO:0009396)3.26491525
59regulation of spindle organization (GO:0090224)3.26402782
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.25407175
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25407175
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25407175
63negative regulation of sister chromatid segregation (GO:0033046)3.25407175
64negative regulation of chromosome segregation (GO:0051985)3.25293795
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25234248
66chromatin assembly or disassembly (GO:0006333)3.25207277
67ribosomal small subunit assembly (GO:0000028)3.24577562
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24389852
69negative regulation of ligase activity (GO:0051352)3.24389852
70ATP-dependent chromatin remodeling (GO:0043044)3.23987387
71positive regulation of chromosome segregation (GO:0051984)3.23436084
72negative regulation of DNA-dependent DNA replication (GO:2000104)3.22583788
73organelle disassembly (GO:1903008)3.21975874
74histone mRNA metabolic process (GO:0008334)3.21773632
75sister chromatid segregation (GO:0000819)3.21501356
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.19914921
77termination of RNA polymerase III transcription (GO:0006386)3.19914921
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19599862
79establishment of viral latency (GO:0019043)3.18867713
80mitotic spindle assembly checkpoint (GO:0007094)3.17645564
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17359083
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17135350
83telomere maintenance via semi-conservative replication (GO:0032201)3.16503120
84respiratory electron transport chain (GO:0022904)3.16494362
85regulation of chromosome segregation (GO:0051983)3.16273607
86mitotic recombination (GO:0006312)3.15591019
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15271098
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15271098
89positive regulation of mitotic sister chromatid separation (GO:1901970)3.15271098
90non-recombinational repair (GO:0000726)3.13904324
91double-strand break repair via nonhomologous end joining (GO:0006303)3.13904324
92telomere maintenance via recombination (GO:0000722)3.13903904
93ribonucleoprotein complex biogenesis (GO:0022613)3.13897428
94protein localization to chromosome (GO:0034502)3.13578037
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13512866
96regulation of mitochondrial translation (GO:0070129)3.13506177
97spindle assembly checkpoint (GO:0071173)3.13474956
98protein targeting to mitochondrion (GO:0006626)3.13350675
99regulation of sister chromatid segregation (GO:0033045)3.13300989
100regulation of mitotic sister chromatid separation (GO:0010965)3.13300989
101regulation of mitotic sister chromatid segregation (GO:0033047)3.13300989
102ribonucleoprotein complex disassembly (GO:0032988)3.12725349
103cotranslational protein targeting to membrane (GO:0006613)3.12022421
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11858090
105translation (GO:0006412)3.10917513
106histone H2A acetylation (GO:0043968)3.10212100
107translational initiation (GO:0006413)3.09959933
108regulation of sister chromatid cohesion (GO:0007063)3.09699699
109electron transport chain (GO:0022900)3.08486679
110DNA-templated transcription, termination (GO:0006353)3.07728853
111regulation of helicase activity (GO:0051095)3.05691173
112viral mRNA export from host cell nucleus (GO:0046784)3.05328170
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04915512
114protein targeting to ER (GO:0045047)3.03702289
115maturation of 5.8S rRNA (GO:0000460)3.02424855
116DNA topological change (GO:0006265)3.02354182
117DNA catabolic process, exonucleolytic (GO:0000738)3.01683816
118protein localization to mitochondrion (GO:0070585)3.01431548
119translational termination (GO:0006415)3.01312057
120rRNA modification (GO:0000154)2.98354742
121inner mitochondrial membrane organization (GO:0007007)2.98331363
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97239341
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.96711963
124rRNA processing (GO:0006364)2.96236719
125ribosomal large subunit biogenesis (GO:0042273)2.96142129
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93060522
127monoubiquitinated protein deubiquitination (GO:0035520)2.91799350
128chromosome segregation (GO:0007059)2.91440758
129RNA splicing, via transesterification reactions (GO:0000375)2.91321999
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89430292
131rRNA metabolic process (GO:0016072)2.88917652
132DNA double-strand break processing (GO:0000729)2.88879266
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86994793
134mRNA splicing, via spliceosome (GO:0000398)2.86994793
135IMP biosynthetic process (GO:0006188)2.86872035
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86675369
137RNA capping (GO:0036260)2.86643092
1387-methylguanosine RNA capping (GO:0009452)2.86643092
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85258860
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.84504075
141telomere maintenance via telomere lengthening (GO:0010833)2.82598280
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.82210242
1437-methylguanosine mRNA capping (GO:0006370)2.79858256
144peptidyl-arginine methylation (GO:0018216)2.77859089
145peptidyl-arginine N-methylation (GO:0035246)2.77859089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38785998
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.70985083
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.19021672
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00538353
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36420640
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34866232
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.23533568
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17369512
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.11012255
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96883977
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96847640
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94740374
13AR_21909140_ChIP-Seq_LNCAP_Human2.91711814
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.83939353
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82144997
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.65306529
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64491466
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62492447
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57549738
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53312685
21* XRN2_22483619_ChIP-Seq_HELA_Human2.40512300
22VDR_23849224_ChIP-Seq_CD4+_Human2.38119009
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29579946
24* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26695869
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.26000020
26DCP1A_22483619_ChIP-Seq_HELA_Human2.20477041
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.20017647
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.19505215
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17155357
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12422719
31ELK1_19687146_ChIP-ChIP_HELA_Human2.04819244
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04158195
33* TTF2_22483619_ChIP-Seq_HELA_Human2.03407593
34* GABP_19822575_ChIP-Seq_HepG2_Human1.96372231
35FOXP3_21729870_ChIP-Seq_TREG_Human1.94561973
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92828530
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90915148
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87486436
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85331841
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.82720852
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81559204
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77245905
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.76116267
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71476347
45KDM5A_27292631_Chip-Seq_BREAST_Human1.68991974
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68177978
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59008470
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53946908
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44812279
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43115542
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43078989
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40335362
53* MYC_18940864_ChIP-ChIP_HL60_Human1.39732910
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38216905
55VDR_22108803_ChIP-Seq_LS180_Human1.35820840
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28075502
57CIITA_25753668_ChIP-Seq_RAJI_Human1.26652282
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.25798831
59IGF1R_20145208_ChIP-Seq_DFB_Human1.25421042
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24651606
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24022329
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23903603
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20117224
64* ZNF274_21170338_ChIP-Seq_K562_Hela1.17309956
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17049772
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.16889744
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15488484
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14839507
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13098913
70ZNF263_19887448_ChIP-Seq_K562_Human1.12112281
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12106263
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11712559
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10638044
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.08794842
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07876394
76TAF15_26573619_Chip-Seq_HEK293_Human1.07173493
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06634645
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04729693
79FUS_26573619_Chip-Seq_HEK293_Human1.02520791
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.02025654
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01984998
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01973083
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00557228
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98268906
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98218048
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98095010
87TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97936236
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97771390
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97548371
90* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97099853
91* EWS_26573619_Chip-Seq_HEK293_Human0.96968174
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96878180
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96406246
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93882457
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.93347850
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92480147
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91636612
98CHD1_26751641_Chip-Seq_LNCaP_Human0.91160658
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90092808
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.89446252
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.88643030
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87864570
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.87513717
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86676782
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86243844
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86129542
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85942014
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85717447
109MYC_22102868_ChIP-Seq_BL_Human0.85586694
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81441789
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80962140
112IRF1_19129219_ChIP-ChIP_H3396_Human0.80277980
113TFEB_21752829_ChIP-Seq_HELA_Human0.80003204
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79930837
115* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79079906
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.78924036
117ELF5_23300383_ChIP-Seq_T47D_Human0.78408732
118* P300_19829295_ChIP-Seq_ESCs_Human0.76845162
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70770536
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70676501
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.68695578
122TP53_22573176_ChIP-Seq_HFKS_Human0.68121575
123ER_23166858_ChIP-Seq_MCF-7_Human0.66980690
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65989780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66644191
2MP0008057_abnormal_DNA_replication4.34699346
3MP0004957_abnormal_blastocyst_morpholog4.12359956
4MP0010094_abnormal_chromosome_stability3.84616984
5MP0003123_paternal_imprinting3.70431604
6MP0003111_abnormal_nucleus_morphology3.58314595
7MP0003077_abnormal_cell_cycle3.48484082
8MP0008877_abnormal_DNA_methylation3.38712590
9MP0010234_abnormal_vibrissa_follicle2.80578427
10MP0003890_abnormal_embryonic-extraembry2.60426003
11MP0003121_genomic_imprinting2.53372691
12MP0008007_abnormal_cellular_replicative2.52876433
13MP0008058_abnormal_DNA_repair2.52815973
14MP0008932_abnormal_embryonic_tissue2.42975704
15MP0001730_embryonic_growth_arrest2.36409827
16MP0010352_gastrointestinal_tract_polyps2.26047090
17MP0003806_abnormal_nucleotide_metabolis2.10083206
18MP0000350_abnormal_cell_proliferation2.08111590
19MP0008995_early_reproductive_senescence1.81477259
20MP0003787_abnormal_imprinting1.77943354
21MP0001697_abnormal_embryo_size1.74029978
22MP0006035_abnormal_mitochondrial_morpho1.73687570
23MP0002084_abnormal_developmental_patter1.73645244
24MP0000537_abnormal_urethra_morphology1.69756428
25MP0001672_abnormal_embryogenesis/_devel1.66143483
26MP0005380_embryogenesis_phenotype1.66143483
27MP0003786_premature_aging1.65067110
28MP0003315_abnormal_perineum_morphology1.64135280
29MP0010307_abnormal_tumor_latency1.63277703
30MP0008789_abnormal_olfactory_epithelium1.62302547
31MP0002085_abnormal_embryonic_tissue1.61541326
32MP0010030_abnormal_orbit_morphology1.59090986
33MP0003119_abnormal_digestive_system1.55518847
34MP0006036_abnormal_mitochondrial_physio1.54774827
35MP0003186_abnormal_redox_activity1.53137072
36MP0003122_maternal_imprinting1.52293602
37MP0003718_maternal_effect1.47589261
38MP0003984_embryonic_growth_retardation1.45589419
39MP0004197_abnormal_fetal_growth/weight/1.42782345
40MP0002088_abnormal_embryonic_growth/wei1.41518464
41MP0002102_abnormal_ear_morphology1.41097212
42MP0009053_abnormal_anal_canal1.40791667
43MP0002938_white_spotting1.39509192
44MP0006292_abnormal_olfactory_placode1.39337829
45MP0002080_prenatal_lethality1.37388631
46MP0003937_abnormal_limbs/digits/tail_de1.37382920
47MP0002210_abnormal_sex_determination1.29050837
48MP0004147_increased_porphyrin_level1.27130360
49MP0005499_abnormal_olfactory_system1.26768101
50MP0005394_taste/olfaction_phenotype1.26768101
51MP0005076_abnormal_cell_differentiation1.26013394
52MP0002086_abnormal_extraembryonic_tissu1.25391066
53MP0000647_abnormal_sebaceous_gland1.22843888
54MP0003567_abnormal_fetal_cardiomyocyte1.21490953
55MP0001529_abnormal_vocalization1.21460113
56MP0001145_abnormal_male_reproductive1.14951968
57MP0009672_abnormal_birth_weight1.14700009
58MP0002751_abnormal_autonomic_nervous1.09234830
59MP0004133_heterotaxia1.08818588
60MP0003861_abnormal_nervous_system1.07839225
61MP0003698_abnormal_male_reproductive1.06823194
62MP0000490_abnormal_crypts_of1.05996075
63MP0000653_abnormal_sex_gland1.05952859
64MP0001929_abnormal_gametogenesis1.05775115
65MP0002160_abnormal_reproductive_system1.05102475
66MP0003221_abnormal_cardiomyocyte_apopto1.04240375
67MP0003941_abnormal_skin_development1.02369531
68MP0001293_anophthalmia1.01612846
69MP0000358_abnormal_cell_content/1.01418534
70MP0002163_abnormal_gland_morphology0.99621829
71MP0003755_abnormal_palate_morphology0.99066783
72MP0000313_abnormal_cell_death0.98359666
73MP0000372_irregular_coat_pigmentation0.96143579
74MP0009697_abnormal_copulation0.94282351
75MP0006072_abnormal_retinal_apoptosis0.92011961
76MP0005187_abnormal_penis_morphology0.90999151
77MP0001188_hyperpigmentation0.89769137
78MP0001286_abnormal_eye_development0.89638427
79MP0002019_abnormal_tumor_incidence0.89395171
80MP0003938_abnormal_ear_development0.88676285
81MP0005389_reproductive_system_phenotype0.85360046
82MP0002653_abnormal_ependyma_morphology0.84670804
83MP0001764_abnormal_homeostasis0.83926488
84MP0006276_abnormal_autonomic_nervous0.83924809
85MP0002233_abnormal_nose_morphology0.83735720
86MP0009703_decreased_birth_body0.81812377
87MP0005084_abnormal_gallbladder_morpholo0.81347802
88MP0002111_abnormal_tail_morphology0.80281529
89MP0001119_abnormal_female_reproductive0.78367351
90MP0004215_abnormal_myocardial_fiber0.78281635
91MP0003880_abnormal_central_pattern0.78089156
92MP0009250_abnormal_appendicular_skeleto0.77814923
93MP0004808_abnormal_hematopoietic_stem0.76304654
94MP0002161_abnormal_fertility/fecundity0.75593550
95MP0002114_abnormal_axial_skeleton0.74435063
96MP0002009_preneoplasia0.73269457
97MP0002234_abnormal_pharynx_morphology0.71747179
98MP0002396_abnormal_hematopoietic_system0.71285209
99MP0005408_hypopigmentation0.70742137
100MP0002736_abnormal_nociception_after0.70674478
101MP0000432_abnormal_head_morphology0.70079926
102MP0002697_abnormal_eye_size0.69836449
103MP0000631_abnormal_neuroendocrine_gland0.69302547
104MP0009379_abnormal_foot_pigmentation0.68492556
105MP0003699_abnormal_female_reproductive0.68089213
106MP0005384_cellular_phenotype0.67911395
107MP0005253_abnormal_eye_physiology0.67900946
108MP0002081_perinatal_lethality0.67330676
109MP0002095_abnormal_skin_pigmentation0.65995962
110MP0005367_renal/urinary_system_phenotyp0.65092492
111MP0000516_abnormal_urinary_system0.65092492
112MP0003763_abnormal_thymus_physiology0.64618374
113MP0000778_abnormal_nervous_system0.64021300
114MP0001984_abnormal_olfaction0.63657881
115MP0003115_abnormal_respiratory_system0.62456951
116MP0005395_other_phenotype0.62312773
117MP0003942_abnormal_urinary_system0.62271195
118MP0002638_abnormal_pupillary_reflex0.61997575
119MP0009046_muscle_twitch0.61785096
120MP0002116_abnormal_craniofacial_bone0.61473593
121MP0005410_abnormal_fertilization0.61366423
122MP0005621_abnormal_cell_physiology0.61016313
123MP0003283_abnormal_digestive_organ0.60607664
124MP0000703_abnormal_thymus_morphology0.60188465
125MP0001919_abnormal_reproductive_system0.60164620
126MP0003935_abnormal_craniofacial_develop0.60052195
127MP0001177_atelectasis0.59107711

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.71022637
2Acute necrotizing encephalopathy (HP:0006965)4.28911659
3Increased hepatocellular lipid droplets (HP:0006565)4.09157590
4Acute encephalopathy (HP:0006846)3.91847780
5Abnormal mitochondria in muscle tissue (HP:0008316)3.82169144
6Progressive macrocephaly (HP:0004481)3.67507885
7Lipid accumulation in hepatocytes (HP:0006561)3.65579968
8Increased CSF lactate (HP:0002490)3.50144679
9Colon cancer (HP:0003003)3.43965802
10Mitochondrial inheritance (HP:0001427)3.43499340
11Abnormality of the labia minora (HP:0012880)3.33322308
12Patellar aplasia (HP:0006443)3.29174634
13Breast hypoplasia (HP:0003187)3.26562140
14Facial hemangioma (HP:0000329)3.19608224
15Aplasia/Hypoplasia of the patella (HP:0006498)3.16370364
16Volvulus (HP:0002580)3.10759649
17Cerebral edema (HP:0002181)3.10128853
18Hepatocellular necrosis (HP:0001404)3.01263069
19Shoulder girdle muscle weakness (HP:0003547)2.87732288
20Abnormality of the anterior horn cell (HP:0006802)2.87204075
21Degeneration of anterior horn cells (HP:0002398)2.87204075
22Chromsome breakage (HP:0040012)2.86794650
23Hepatic necrosis (HP:0002605)2.85084659
24Carpal bone hypoplasia (HP:0001498)2.83913413
25Increased serum pyruvate (HP:0003542)2.82120417
26Medulloblastoma (HP:0002885)2.78708554
27Pelvic girdle muscle weakness (HP:0003749)2.69697863
28Renal Fanconi syndrome (HP:0001994)2.69356258
29Increased serum lactate (HP:0002151)2.64271889
30Abnormality of glycolysis (HP:0004366)2.62220380
31Cerebral hypomyelination (HP:0006808)2.59819690
323-Methylglutaconic aciduria (HP:0003535)2.59577536
33Aplastic anemia (HP:0001915)2.59404342
34Abnormality of chromosome stability (HP:0003220)2.57542278
35Oral leukoplakia (HP:0002745)2.56599783
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55139663
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55139663
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.53291126
39Irregular epiphyses (HP:0010582)2.52312361
4011 pairs of ribs (HP:0000878)2.51996440
41Glossoptosis (HP:0000162)2.51783316
42Leukodystrophy (HP:0002415)2.50116041
43Abnormality of methionine metabolism (HP:0010901)2.48492807
44Supernumerary spleens (HP:0009799)2.46064683
45Abnormality of the preputium (HP:0100587)2.42505895
46Increased intramyocellular lipid droplets (HP:0012240)2.39692184
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38174362
48Abnormality of the musculature of the pelvis (HP:0001469)2.35909541
49Abnormality of the hip-girdle musculature (HP:0001445)2.35909541
50Neoplasm of the pancreas (HP:0002894)2.35804908
51Impulsivity (HP:0100710)2.34502992
52Lactic acidosis (HP:0003128)2.33926246
53Biliary tract neoplasm (HP:0100574)2.32846726
54Methylmalonic acidemia (HP:0002912)2.31568448
55Congenital, generalized hypertrichosis (HP:0004540)2.31007283
56Megaloblastic anemia (HP:0001889)2.29999226
57Atresia of the external auditory canal (HP:0000413)2.28782432
58Deviation of the thumb (HP:0009603)2.26690084
59Overlapping toe (HP:0001845)2.25241680
60Abnormality of cells of the erythroid lineage (HP:0012130)2.24298116
61Multiple enchondromatosis (HP:0005701)2.23918285
62Proximal placement of thumb (HP:0009623)2.23623505
63Exertional dyspnea (HP:0002875)2.22563570
64Stenosis of the external auditory canal (HP:0000402)2.22305097
65Meckel diverticulum (HP:0002245)2.21647182
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.21459938
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21451880
68Microvesicular hepatic steatosis (HP:0001414)2.18696975
69Abnormal lung lobation (HP:0002101)2.18356971
70Respiratory difficulties (HP:0002880)2.18232267
71Aplasia/Hypoplasia of the sternum (HP:0006714)2.18176783
72Selective tooth agenesis (HP:0001592)2.17928176
73Absent thumb (HP:0009777)2.16070631
74Horseshoe kidney (HP:0000085)2.15302673
75Absent radius (HP:0003974)2.14310413
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13844072
77Ependymoma (HP:0002888)2.12789784
78Missing ribs (HP:0000921)2.11792000
79Abnormality of the ileum (HP:0001549)2.09501252
80Rough bone trabeculation (HP:0100670)2.09085450
81Capillary hemangiomas (HP:0005306)2.07917624
82Respiratory failure (HP:0002878)2.05696627
83Nephroblastoma (Wilms tumor) (HP:0002667)2.04691111
84Rhabdomyosarcoma (HP:0002859)2.04565015
85Papillary thyroid carcinoma (HP:0002895)2.03970319
86Amyotrophic lateral sclerosis (HP:0007354)2.02033148
87Duodenal stenosis (HP:0100867)2.00528715
88Small intestinal stenosis (HP:0012848)2.00528715
89Absent forearm bone (HP:0003953)2.00388345
90Aplasia involving forearm bones (HP:0009822)2.00388345
91Embryonal renal neoplasm (HP:0011794)1.99715816
92CNS hypomyelination (HP:0003429)1.98179363
93Pallor (HP:0000980)1.97638346
94Abnormality of serum amino acid levels (HP:0003112)1.96941359
95Hyperglycinemia (HP:0002154)1.96365225
96Abnormal number of incisors (HP:0011064)1.95584158
97Exercise intolerance (HP:0003546)1.94901027
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94828511
99Premature ovarian failure (HP:0008209)1.87207366
100Optic disc pallor (HP:0000543)1.86402222
101Abnormal number of erythroid precursors (HP:0012131)1.85616486
102Oligodactyly (HP:0012165)1.85561672
103Increased nuchal translucency (HP:0010880)1.85211688
104Rib fusion (HP:0000902)1.85146574
105Abnormality of alanine metabolism (HP:0010916)1.85028904
106Hyperalaninemia (HP:0003348)1.85028904
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85028904
108Neoplasm of the colon (HP:0100273)1.82257337
109Postnatal microcephaly (HP:0005484)1.82124314
110Myelodysplasia (HP:0002863)1.82061598
111Cortical dysplasia (HP:0002539)1.80314669
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79436738
113Abnormality of renal resorption (HP:0011038)1.78631058
114Type I transferrin isoform profile (HP:0003642)1.78283983
115Abnormal biliary tract morphology (HP:0012440)1.78000860
116Lethargy (HP:0001254)1.77872213
117Abnormality of placental membranes (HP:0011409)1.77597447
118Amniotic constriction ring (HP:0009775)1.77597447
119Increased muscle lipid content (HP:0009058)1.76933189
120Fibular aplasia (HP:0002990)1.75552465
121Breast carcinoma (HP:0003002)1.75258770
122Shawl scrotum (HP:0000049)1.75121226
123Abnormality of the duodenum (HP:0002246)1.74978502
124Basal cell carcinoma (HP:0002671)1.74682404
125Abnormality of homocysteine metabolism (HP:0010919)1.74674581
126Homocystinuria (HP:0002156)1.74674581
127Sloping forehead (HP:0000340)1.72607826
128Reticulocytopenia (HP:0001896)1.72302663
129Facial cleft (HP:0002006)1.72278893
130Small epiphyses (HP:0010585)1.71497848
131Methylmalonic aciduria (HP:0012120)1.71330271
132Agnosia (HP:0010524)1.71030078
133Microretrognathia (HP:0000308)1.68234256
134Macrocytic anemia (HP:0001972)1.68145656
135Trismus (HP:0000211)1.67736331
136Pancytopenia (HP:0001876)1.67373566
137X-linked dominant inheritance (HP:0001423)1.66307600
138Cleft eyelid (HP:0000625)1.66140028
139Oligodactyly (hands) (HP:0001180)1.65147651
140Abnormality of the pons (HP:0007361)1.64333996
141Thyroid carcinoma (HP:0002890)1.64219726
142Unsteady gait (HP:0002317)1.63940421
143Breast aplasia (HP:0100783)1.63456943
144Secondary amenorrhea (HP:0000869)1.63261660
145Hypoglycemic coma (HP:0001325)1.63179815
146Abnormality of the calcaneus (HP:0008364)1.63072746
147Cellular immunodeficiency (HP:0005374)1.61348656
148CNS demyelination (HP:0007305)1.59900397
149Abnormality of the astrocytes (HP:0100707)1.59444025
150Astrocytoma (HP:0009592)1.59444025
151Glioma (HP:0009733)1.59008037
152Abnormal protein N-linked glycosylation (HP:0012347)1.58638362
153Abnormal glycosylation (HP:0012345)1.58638362
154Short thumb (HP:0009778)1.58422576
155Abnormality of the proximal phalanges of the hand (HP:0009834)1.57856311
156Cafe-au-lait spot (HP:0000957)1.55041813
157Tracheoesophageal fistula (HP:0002575)1.54832463
158Squamous cell carcinoma (HP:0002860)1.53785006
159Genu varum (HP:0002970)1.52255786
160Triphalangeal thumb (HP:0001199)1.51993390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.57833369
2BUB13.73606147
3WEE13.47913646
4PLK43.38543798
5SRPK13.13549412
6MST42.76087313
7ACVR1B2.53334304
8NEK22.40965158
9PLK32.40833045
10MKNK12.34920406
11EIF2AK12.31346596
12LATS22.29235223
13TSSK62.27624078
14TTK2.22328054
15NEK12.01584190
16TRIM281.99801628
17MKNK21.95713935
18VRK21.95458071
19PLK11.89222959
20PNCK1.84716949
21LATS11.68753304
22STK161.65971357
23CDK121.64523836
24DYRK31.62028900
25STK38L1.58527269
26BRSK21.50798946
27AURKB1.50217064
28EIF2AK31.43790831
29VRK11.43463591
30PASK1.42146588
31CHEK21.33142225
32ATR1.32233636
33WNK31.30131732
34PLK21.29993134
35AURKA1.28429908
36NME11.22807470
37CHEK11.21911810
38TNIK1.19712115
39DYRK21.19599377
40MELK1.12320588
41RPS6KB21.11300145
42SCYL21.09953580
43BRD41.09440701
44EIF2AK21.08558618
45CDK71.04381405
46BRSK11.03112598
47PDK20.99701526
48KSR10.98334562
49RPS6KA40.97351290
50ATM0.96941951
51BMPR1B0.92896430
52MAP3K50.92366262
53MAP3K60.90786662
54MAP3K120.88160580
55MAP3K80.87160456
56CDK20.86516590
57CCNB10.86081380
58NME20.84568511
59STK30.84169828
60BRAF0.83958881
61BCR0.82837210
62CDK30.82642078
63CSNK1G30.81655049
64TAOK10.80841703
65MAP3K40.80415445
66CSNK1E0.80035685
67ALK0.76948648
68CASK0.76373684
69CDK190.74181670
70CSNK2A20.74073490
71MARK10.73855749
72TAF10.73469233
73LIMK10.73415798
74ERBB30.72703895
75CDK10.71228740
76CLK10.70810809
77CDK80.70235734
78CDK40.69262786
79ZAK0.68916877
80FRK0.68810608
81BCKDK0.66236025
82PRKCI0.62033806
83EPHA20.62033525
84TGFBR10.61811870
85CSNK1G20.60931615
86MINK10.60407120
87CSNK1G10.59992798
88STK390.58754104
89MAP3K90.58111219
90CSNK2A10.57546730
91ERBB40.57100098
92TESK20.56643539
93MAP2K70.55806888
94DYRK1A0.55065136
95PBK0.54490594
96BMPR20.53965433
97OXSR10.53237877
98STK40.52820220
99CDK140.51038251
100FGFR10.49633749
101CDK11A0.49086333
102MAP3K110.48010913
103CDK180.47486495
104RAF10.46581927
105MAPK130.45802719
106CSNK1A1L0.45658609
107CDK150.44086446
108TEC0.42959962
109PRKDC0.42142846
110NTRK30.41746333
111MAP4K20.41112295
112MAP3K30.40342055
113PIM10.39926704
114WNK40.38183180
115PAK40.38104982
116NUAK10.37764016
117RPS6KB10.37023522
118PAK10.35338070
119CDK60.34974840
120RPS6KA50.32532497
121STK100.31822651
122MAPK140.31280365
123PRKACB0.29638907
124UHMK10.27820671
125STK240.26362308
126GSK3B0.25611419
127SIK30.25476271

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.09964572
2DNA replication_Homo sapiens_hsa030303.82801547
3Mismatch repair_Homo sapiens_hsa034303.64208279
4RNA polymerase_Homo sapiens_hsa030203.61512721
5RNA transport_Homo sapiens_hsa030133.58758377
6Spliceosome_Homo sapiens_hsa030403.31159008
7Proteasome_Homo sapiens_hsa030503.24649985
8Cell cycle_Homo sapiens_hsa041103.13143270
9Nucleotide excision repair_Homo sapiens_hsa034202.51929675
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40480457
11Ribosome_Homo sapiens_hsa030102.39642825
12Homologous recombination_Homo sapiens_hsa034402.34934081
13mRNA surveillance pathway_Homo sapiens_hsa030152.24643977
14Base excision repair_Homo sapiens_hsa034102.21141977
15Basal transcription factors_Homo sapiens_hsa030222.19697981
16RNA degradation_Homo sapiens_hsa030182.12709754
17Non-homologous end-joining_Homo sapiens_hsa034502.10209677
18Pyrimidine metabolism_Homo sapiens_hsa002402.07410963
19One carbon pool by folate_Homo sapiens_hsa006701.96365498
20Fanconi anemia pathway_Homo sapiens_hsa034601.76664805
21Oocyte meiosis_Homo sapiens_hsa041141.76441538
22p53 signaling pathway_Homo sapiens_hsa041151.65194298
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45569818
24Propanoate metabolism_Homo sapiens_hsa006401.45383304
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43676823
26Epstein-Barr virus infection_Homo sapiens_hsa051691.37730506
27Steroid biosynthesis_Homo sapiens_hsa001001.35596160
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33482940
29Pyruvate metabolism_Homo sapiens_hsa006201.22980742
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22245267
31Purine metabolism_Homo sapiens_hsa002301.13097866
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09140417
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08940990
34Thyroid cancer_Homo sapiens_hsa052160.99245955
35Folate biosynthesis_Homo sapiens_hsa007900.95790289
36TGF-beta signaling pathway_Homo sapiens_hsa043500.93757615
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92224457
38Cardiac muscle contraction_Homo sapiens_hsa042600.92104888
39Protein export_Homo sapiens_hsa030600.89343395
40Hippo signaling pathway_Homo sapiens_hsa043900.88025621
41Viral carcinogenesis_Homo sapiens_hsa052030.86320061
42Colorectal cancer_Homo sapiens_hsa052100.85161502
43Huntingtons disease_Homo sapiens_hsa050160.82068691
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81631281
45Alcoholism_Homo sapiens_hsa050340.80031019
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79991273
47MicroRNAs in cancer_Homo sapiens_hsa052060.79460978
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78248131
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75160512
50Fatty acid elongation_Homo sapiens_hsa000620.72230952
51Antigen processing and presentation_Homo sapiens_hsa046120.72181402
52HTLV-I infection_Homo sapiens_hsa051660.72119752
53Systemic lupus erythematosus_Homo sapiens_hsa053220.70547052
54Parkinsons disease_Homo sapiens_hsa050120.65067911
55Carbon metabolism_Homo sapiens_hsa012000.64944455
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64401520
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63285127
58Biosynthesis of amino acids_Homo sapiens_hsa012300.61289088
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61137801
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58272476
61Phototransduction_Homo sapiens_hsa047440.57530054
62Metabolic pathways_Homo sapiens_hsa011000.57474175
63Wnt signaling pathway_Homo sapiens_hsa043100.57382585
64Butanoate metabolism_Homo sapiens_hsa006500.56069123
65Dopaminergic synapse_Homo sapiens_hsa047280.52302806
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.52028693
67Long-term potentiation_Homo sapiens_hsa047200.51909660
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51661777
69mTOR signaling pathway_Homo sapiens_hsa041500.51493335
70Vitamin B6 metabolism_Homo sapiens_hsa007500.51194780
71Glutathione metabolism_Homo sapiens_hsa004800.50766358
72Herpes simplex infection_Homo sapiens_hsa051680.50605609
73Tight junction_Homo sapiens_hsa045300.47439462
74Type I diabetes mellitus_Homo sapiens_hsa049400.46004017
75Amphetamine addiction_Homo sapiens_hsa050310.45567211
76Oxidative phosphorylation_Homo sapiens_hsa001900.44643769
77Adherens junction_Homo sapiens_hsa045200.43896600
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43643264
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43555908
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.43383793
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.43371121
82Prostate cancer_Homo sapiens_hsa052150.41467352
83Hedgehog signaling pathway_Homo sapiens_hsa043400.41288916
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40785041
85Small cell lung cancer_Homo sapiens_hsa052220.40171301
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39739750
87Bladder cancer_Homo sapiens_hsa052190.39479635
88Selenocompound metabolism_Homo sapiens_hsa004500.38967456
89Basal cell carcinoma_Homo sapiens_hsa052170.37061397
90Shigellosis_Homo sapiens_hsa051310.35644049
91FoxO signaling pathway_Homo sapiens_hsa040680.35004905
92Glioma_Homo sapiens_hsa052140.34657882
93Chronic myeloid leukemia_Homo sapiens_hsa052200.34583033
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34171843
95Hepatitis B_Homo sapiens_hsa051610.34028169
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33965099
97Pancreatic cancer_Homo sapiens_hsa052120.33656402
98Circadian rhythm_Homo sapiens_hsa047100.33534040
99Regulation of autophagy_Homo sapiens_hsa041400.32943884
100Pathways in cancer_Homo sapiens_hsa052000.32871895
101Endometrial cancer_Homo sapiens_hsa052130.32791696
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32013936
103Melanoma_Homo sapiens_hsa052180.31168409
104Sulfur metabolism_Homo sapiens_hsa009200.30858842
105Collecting duct acid secretion_Homo sapiens_hsa049660.29592297
106Sulfur relay system_Homo sapiens_hsa041220.28476629
107Fatty acid metabolism_Homo sapiens_hsa012120.28420175
108Nicotine addiction_Homo sapiens_hsa050330.27858864
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.27161847
110HIF-1 signaling pathway_Homo sapiens_hsa040660.26958109
111Peroxisome_Homo sapiens_hsa041460.26389415
112Olfactory transduction_Homo sapiens_hsa047400.25903081
113Cocaine addiction_Homo sapiens_hsa050300.25032979
114Renal cell carcinoma_Homo sapiens_hsa052110.24718437
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24629370
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23990566
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22995415
118Vibrio cholerae infection_Homo sapiens_hsa051100.22472395
119ErbB signaling pathway_Homo sapiens_hsa040120.22052291
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.21976947
121Estrogen signaling pathway_Homo sapiens_hsa049150.21924117
122Non-small cell lung cancer_Homo sapiens_hsa052230.21129399
123Asthma_Homo sapiens_hsa053100.19755813
124N-Glycan biosynthesis_Homo sapiens_hsa005100.19741170
125Synaptic vesicle cycle_Homo sapiens_hsa047210.19368306
126Alzheimers disease_Homo sapiens_hsa050100.18798461
127Long-term depression_Homo sapiens_hsa047300.18254395
128Legionellosis_Homo sapiens_hsa051340.18129519
129T cell receptor signaling pathway_Homo sapiens_hsa046600.17814274
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17377096
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16814965
132Serotonergic synapse_Homo sapiens_hsa047260.15752931
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15064651
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.14912271
135Axon guidance_Homo sapiens_hsa043600.14558616
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14524704
137Gap junction_Homo sapiens_hsa045400.13577322
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.13311535
139Melanogenesis_Homo sapiens_hsa049160.13042562
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12131820
141Vitamin digestion and absorption_Homo sapiens_hsa049770.11435270
142Retinol metabolism_Homo sapiens_hsa008300.09598224
143Pentose phosphate pathway_Homo sapiens_hsa000300.07724874
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06901534
145Fatty acid degradation_Homo sapiens_hsa000710.06388723
146Caffeine metabolism_Homo sapiens_hsa002320.05106533
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04925077
148Arginine and proline metabolism_Homo sapiens_hsa003300.04890484
149beta-Alanine metabolism_Homo sapiens_hsa004100.04759857
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02799048
151Starch and sucrose metabolism_Homo sapiens_hsa005000.01580192
152Chemical carcinogenesis_Homo sapiens_hsa052040.01540090

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