ZC3H18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA packaging (GO:0006323)6.04514945
2nuclear pore complex assembly (GO:0051292)4.70194026
3nucleosome disassembly (GO:0006337)4.66159260
4protein-DNA complex disassembly (GO:0032986)4.66159260
5nuclear pore organization (GO:0006999)4.56142105
6pre-miRNA processing (GO:0031054)4.50822558
7folic acid-containing compound biosynthetic process (GO:0009396)4.41224890
8protein localization to kinetochore (GO:0034501)4.39827013
9heterochromatin organization (GO:0070828)4.32362246
10DNA unwinding involved in DNA replication (GO:0006268)4.26034916
11acrosome reaction (GO:0007340)4.22376351
12regulation of translational fidelity (GO:0006450)4.21779877
13negative regulation of glycogen biosynthetic process (GO:0045719)4.04896180
14regulation of histone H3-K27 methylation (GO:0061085)3.92319728
15protein localization to chromosome, centromeric region (GO:0071459)3.89345292
16sperm capacitation (GO:0048240)3.85195491
17response to pheromone (GO:0019236)3.84552879
18rRNA transcription (GO:0009303)3.80793591
19sperm motility (GO:0030317)3.78444402
20microtubule depolymerization (GO:0007019)3.76317607
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73699648
22V(D)J recombination (GO:0033151)3.72931066
23mitotic sister chromatid cohesion (GO:0007064)3.72299643
24mitotic nuclear envelope disassembly (GO:0007077)3.69038182
25mitotic chromosome condensation (GO:0007076)3.67689317
26chaperone-mediated protein complex assembly (GO:0051131)3.62011994
27chromatin assembly (GO:0031497)3.61860966
28regulation of RNA export from nucleus (GO:0046831)3.59699606
29negative regulation of histone methylation (GO:0031061)3.58985735
30mitotic sister chromatid segregation (GO:0000070)3.56268071
31RNA stabilization (GO:0043489)3.53620688
32mRNA stabilization (GO:0048255)3.53620688
33sister chromatid segregation (GO:0000819)3.53165855
34regulation of gene silencing by RNA (GO:0060966)3.52229225
35regulation of posttranscriptional gene silencing (GO:0060147)3.52229225
36regulation of gene silencing by miRNA (GO:0060964)3.52229225
37positive regulation of gene expression, epigenetic (GO:0045815)3.49859610
38regulation of chromatin binding (GO:0035561)3.49778395
39binding of sperm to zona pellucida (GO:0007339)3.48269653
40regulation of hippo signaling (GO:0035330)3.47012694
41DNA replication-dependent nucleosome organization (GO:0034723)3.44517604
42DNA replication-dependent nucleosome assembly (GO:0006335)3.44517604
43membrane disassembly (GO:0030397)3.43793268
44nuclear envelope disassembly (GO:0051081)3.43793268
45pore complex assembly (GO:0046931)3.43727983
46activation of MAPKKK activity (GO:0000185)3.43636436
47regulation of histone H3-K9 methylation (GO:0051570)3.42641396
48dosage compensation (GO:0007549)3.38179217
49DNA duplex unwinding (GO:0032508)3.38056851
50DNA geometric change (GO:0032392)3.35825205
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34151468
52fusion of sperm to egg plasma membrane (GO:0007342)3.32784145
53negative regulation of mRNA processing (GO:0050686)3.31584831
54histone H4 deacetylation (GO:0070933)3.29951622
55histone H3-K36 demethylation (GO:0070544)3.29462479
56regulation of histone methylation (GO:0031060)3.28735962
57negative regulation of RNA splicing (GO:0033119)3.24815573
58mitotic G1 DNA damage checkpoint (GO:0031571)3.24393559
59leukocyte aggregation (GO:0070486)3.23491635
60sperm-egg recognition (GO:0035036)3.22144417
61RNA localization (GO:0006403)3.21179501
62spermatid development (GO:0007286)3.15584304
63negative regulation of mRNA metabolic process (GO:1903312)3.15199825
64regulation of sister chromatid cohesion (GO:0007063)3.14428671
65negative regulation of DNA-templated transcription, elongation (GO:0032785)3.13734488
66regulation of translational termination (GO:0006449)3.13587661
67embryonic skeletal joint morphogenesis (GO:0060272)3.12597745
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.12377160
69histone H2A monoubiquitination (GO:0035518)3.08960654
70regulation of histone H3-K4 methylation (GO:0051569)3.06240259
71reproduction (GO:0000003)3.06227311
72IMP biosynthetic process (GO:0006188)3.03176437
73histone H3-K9 demethylation (GO:0033169)3.02030285
74negative regulation of histone modification (GO:0031057)3.00157291
75regulation of spindle organization (GO:0090224)2.99414647
76regulation of mitotic spindle organization (GO:0060236)2.99328016
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96024613
78multicellular organism reproduction (GO:0032504)2.96014517
79regulation of nucleobase-containing compound transport (GO:0032239)2.94028734
80phosphatidylethanolamine biosynthetic process (GO:0006646)2.93361355
81sexual reproduction (GO:0019953)2.92498593
82intracellular estrogen receptor signaling pathway (GO:0030520)2.92164887
83mitotic G1/S transition checkpoint (GO:0044819)2.91154324
84positive regulation of chromosome segregation (GO:0051984)2.90112166
85mitotic metaphase plate congression (GO:0007080)2.88509893
86chromatin assembly or disassembly (GO:0006333)2.87639190
87peptidyl-arginine omega-N-methylation (GO:0035247)2.86397239
88histone H3 deacetylation (GO:0070932)2.85626030
89tetrahydrofolate metabolic process (GO:0046653)2.85520069
90negative regulation of glycogen metabolic process (GO:0070874)2.85481124
91positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.84953699
92protein polyglutamylation (GO:0018095)2.84296694
93negative regulation of organelle assembly (GO:1902116)2.83847957
94paraxial mesoderm development (GO:0048339)2.81051443
95trophectodermal cell differentiation (GO:0001829)2.80707780
96DNA conformation change (GO:0071103)2.78487422
97protein localization to chromosome (GO:0034502)2.77772838
98negative regulation of erythrocyte differentiation (GO:0045647)2.77699527
99establishment of apical/basal cell polarity (GO:0035089)2.77212186
100nuclear envelope organization (GO:0006998)2.76964553
101positive regulation of histone deacetylation (GO:0031065)2.76628755
102apoptotic process involved in morphogenesis (GO:0060561)2.76468051
103cellular response to pH (GO:0071467)2.76425029
104regulation of stem cell maintenance (GO:2000036)2.76155186
1053-UTR-mediated mRNA stabilization (GO:0070935)2.76115423
106erythrocyte maturation (GO:0043249)2.75420429
107DNA replication initiation (GO:0006270)2.75371662
108histone H4-K12 acetylation (GO:0043983)2.73280297
109G1 DNA damage checkpoint (GO:0044783)2.72611044
110DNA methylation (GO:0006306)2.72580648
111DNA alkylation (GO:0006305)2.72580648
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.72262789
113synaptonemal complex assembly (GO:0007130)2.69312806
114regulation of mRNA stability (GO:0043488)2.67814246
115DNA strand elongation involved in DNA replication (GO:0006271)2.65779576
116negative regulation of chromatin modification (GO:1903309)2.65357877
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64517409
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64517409
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.64517409
120nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64370578
121peptidyl-lysine dimethylation (GO:0018027)2.64353931
122histone lysine demethylation (GO:0070076)2.64350646
123IMP metabolic process (GO:0046040)2.63137001
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61963689
125NLS-bearing protein import into nucleus (GO:0006607)2.61929568
126nucleus organization (GO:0006997)2.61791444
127alternative mRNA splicing, via spliceosome (GO:0000380)2.61207003
128chromosome condensation (GO:0030261)2.60824671
129chromatin silencing (GO:0006342)2.59758562
130centriole replication (GO:0007099)2.58409284
131gene silencing (GO:0016458)2.58031786
132glucocorticoid receptor signaling pathway (GO:0042921)2.57518980
133modulation by virus of host process (GO:0019054)2.57442981
134metaphase plate congression (GO:0051310)2.56604307
135single strand break repair (GO:0000012)2.55872739
136mRNA transport (GO:0051028)2.55365036
137histone demethylation (GO:0016577)2.55181777
138negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.54710128
139DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54370441
140response to UV-C (GO:0010225)2.54216683
141regulation of RNA stability (GO:0043487)2.54120766
142maternal placenta development (GO:0001893)2.53372027
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.52797105
144UV protection (GO:0009650)2.52669018
145regulation of Rab GTPase activity (GO:0032313)2.52438085
146positive regulation of Rab GTPase activity (GO:0032851)2.52438085
147regulation of gene silencing (GO:0060968)2.51340945
148negative regulation of cell size (GO:0045792)2.51010181
149hematopoietic stem cell differentiation (GO:0060218)2.51009052
150regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50704158
151formation of translation preinitiation complex (GO:0001731)2.49470441
152cell-cell recognition (GO:0009988)2.48174231
153DNA strand elongation (GO:0022616)2.47348263
154phosphatidylethanolamine metabolic process (GO:0046337)2.47193165
155regulation of integrin activation (GO:0033623)2.46992314
156translesion synthesis (GO:0019985)2.46259442
157negative regulation of gene expression, epigenetic (GO:0045814)2.45484841
158histone deacetylation (GO:0016575)2.44632092
159microtubule polymerization or depolymerization (GO:0031109)2.44490297
160centriole assembly (GO:0098534)2.44415277
161glycine metabolic process (GO:0006544)2.43858344
162calcium ion-dependent exocytosis (GO:0017156)2.41942550
163DNA topological change (GO:0006265)2.41752943
164regulation of DNA damage checkpoint (GO:2000001)2.41194355
165gene silencing by RNA (GO:0031047)2.40023529
166nucleobase biosynthetic process (GO:0046112)2.39997583
167embryonic process involved in female pregnancy (GO:0060136)2.39621471
168DNA replication checkpoint (GO:0000076)2.38082564
169kinetochore organization (GO:0051383)2.38003691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.90151574
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.97539284
3MYC_22102868_ChIP-Seq_BL_Human3.20535869
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.17354540
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92876341
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87595753
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.72711724
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71411399
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71038314
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53897934
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38247410
12* P68_20966046_ChIP-Seq_HELA_Human2.20627300
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19752591
14VDR_21846776_ChIP-Seq_THP-1_Human2.17379520
15AR_21909140_ChIP-Seq_LNCAP_Human2.04125172
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94284166
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.88446273
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78261366
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74123765
20SMC4_20622854_ChIP-Seq_HELA_Human1.73403890
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72675569
22TCF7_22412390_ChIP-Seq_EML_Mouse1.72562123
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71138653
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.70723931
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67935419
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62411189
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61663702
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59906891
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.59331801
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57255219
31KDM2B_26808549_Chip-Seq_DND41_Human1.55911468
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.55024742
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.54510882
34PHF8_20622854_ChIP-Seq_HELA_Human1.53201311
35BCL6_27268052_Chip-Seq_Bcells_Human1.51596541
36BCOR_27268052_Chip-Seq_Bcells_Human1.51309925
37XRN2_22483619_ChIP-Seq_HELA_Human1.51164805
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.47872851
39* E2F1_20622854_ChIP-Seq_HELA_Human1.47706025
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47505553
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43029200
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40419353
43* KDM5A_27292631_Chip-Seq_BREAST_Human1.40171286
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38574928
45UTX_26944678_Chip-Seq_JUKART_Human1.38535765
46KDM2B_26808549_Chip-Seq_K562_Human1.38305122
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37797843
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36933894
49CIITA_25753668_ChIP-Seq_RAJI_Human1.36667032
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.36455080
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35136449
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34951646
53RARA_24833708_ChIP-Seq_LIVER_Mouse1.34586178
54MAF_26560356_Chip-Seq_TH1_Human1.34304419
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34212393
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33380541
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32933582
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30712123
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30436880
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29724286
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29503979
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29503979
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29503979
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28558004
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27410138
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26733293
67ATF3_27146783_Chip-Seq_COLON_Human1.26472250
68EZH2_22144423_ChIP-Seq_EOC_Human1.25795204
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25066229
70TP53_22127205_ChIP-Seq_IMR90_Human1.23888302
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23810611
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22668267
73NCOR1_26117541_ChIP-Seq_K562_Human1.21672119
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21161510
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21026263
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20742994
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20274498
78FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19674048
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18442233
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.18287552
81CTCF_27219007_Chip-Seq_Bcells_Human1.18239936
82CREB1_26743006_Chip-Seq_LNCaP_Human1.14930807
83DROSHA_22980978_ChIP-Seq_HELA_Human1.14163743
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13833481
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13520488
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13473308
87CTCF_21964334_Chip-Seq_Bcells_Human1.13426318
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12754414
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12499743
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12349253
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12150988
92RACK7_27058665_Chip-Seq_MCF-7_Human1.11522205
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11188546
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11029311
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.10889918
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10823503
97MYB_26560356_Chip-Seq_TH1_Human1.10441576
98OCT4_19829295_ChIP-Seq_ESCs_Human1.10156639
99RAC3_21632823_ChIP-Seq_H3396_Human1.09694315
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.09089989
101* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09048570
102ZNF263_19887448_ChIP-Seq_K562_Human1.08980780
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08798515
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07813682
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07580354
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07500283
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07387847
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06887324
109ETS1_21867929_ChIP-Seq_TH2_Mouse1.06823315
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06576128
111CTCF_20526341_ChIP-Seq_ESCs_Human1.05967583
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05895881
113GATA6_25053715_ChIP-Seq_YYC3_Human1.05884594
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05819089
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04435072
116SA1_27219007_Chip-Seq_Bcells_Human1.04205207
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03895976
118CLOCK_20551151_ChIP-Seq_293T_Human1.03363363
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.03332013
120TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03137811
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03099899
122TP63_22573176_ChIP-Seq_HFKS_Human1.02772769
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02709307
124CHD1_26751641_Chip-Seq_LNCaP_Human1.01084135
125RUNX1_27514584_Chip-Seq_MCF-7_Human1.00913320
126SCL_19346495_ChIP-Seq_HPC-7_Human0.99789442
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99556865
128CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99457441
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.98708426
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98523295
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98217837
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98208494
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97789527
134MAF_26560356_Chip-Seq_TH2_Human0.97573635
135* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97453033
136JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97154866
137* TFEB_21752829_ChIP-Seq_HELA_Human0.96866824
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96594740
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96282343
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.96049955
141* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96047746
142P300_27268052_Chip-Seq_Bcells_Human0.95487728
143VDR_24763502_ChIP-Seq_THP-1_Human0.94213203
144TTF2_22483619_ChIP-Seq_HELA_Human0.93522479
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92883421
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89889627
147* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88973654
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88066203
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87510964
150* LXR_22292898_ChIP-Seq_THP-1_Human0.87380751
151PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87181433
152* GABP_19822575_ChIP-Seq_HepG2_Human0.87172559
153POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86771301
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86692994
155RUNX1_22412390_ChIP-Seq_EML_Mouse0.86465592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.24740647
2MP0005410_abnormal_fertilization4.59186892
3MP0001348_abnormal_lacrimal_gland4.03277488
4MP0003705_abnormal_hypodermis_morpholog3.47624984
5MP0000678_abnormal_parathyroid_gland3.31530851
6MP0010352_gastrointestinal_tract_polyps3.00603397
7MP0003111_abnormal_nucleus_morphology2.98279652
8MP0003693_abnormal_embryo_hatching2.84698104
9MP0005076_abnormal_cell_differentiation2.80276710
10MP0002837_dystrophic_cardiac_calcinosis2.58551217
11MP0010094_abnormal_chromosome_stability2.56318685
12MP0004957_abnormal_blastocyst_morpholog2.50741614
13MP0003077_abnormal_cell_cycle2.50329360
14MP0008057_abnormal_DNA_replication2.39853197
15MP0001730_embryonic_growth_arrest2.20192693
16MP0006292_abnormal_olfactory_placode2.18662192
17MP0009278_abnormal_bone_marrow2.11641975
18MP0002396_abnormal_hematopoietic_system2.05242209
19MP0010307_abnormal_tumor_latency2.03221025
20MP0001849_ear_inflammation1.96951175
21MP0000350_abnormal_cell_proliferation1.93793774
22MP0005670_abnormal_white_adipose1.83991122
23MP0001672_abnormal_embryogenesis/_devel1.80819736
24MP0005380_embryogenesis_phenotype1.80819736
25MP0004185_abnormal_adipocyte_glucose1.76550995
26MP0004197_abnormal_fetal_growth/weight/1.75261787
27MP0003566_abnormal_cell_adhesion1.72913938
28MP0003984_embryonic_growth_retardation1.72536939
29MP0003698_abnormal_male_reproductive1.71078321
30MP0002088_abnormal_embryonic_growth/wei1.70508725
31MP0003878_abnormal_ear_physiology1.69351943
32MP0005377_hearing/vestibular/ear_phenot1.69351943
33MP0002084_abnormal_developmental_patter1.69167704
34MP0002086_abnormal_extraembryonic_tissu1.68817179
35MP0001929_abnormal_gametogenesis1.66678612
36MP0001853_heart_inflammation1.63732695
37MP0005451_abnormal_body_composition1.63342459
38MP0001697_abnormal_embryo_size1.60640618
39MP0009053_abnormal_anal_canal1.60253466
40MP0002085_abnormal_embryonic_tissue1.55424084
41MP0003300_gastrointestinal_ulcer1.53011523
42MP0002089_abnormal_postnatal_growth/wei1.49481707
43MP0000049_abnormal_middle_ear1.46606588
44MP0005623_abnormal_meninges_morphology1.44908311
45MP0004808_abnormal_hematopoietic_stem1.43664993
46MP0008007_abnormal_cellular_replicative1.42089942
47MP0005397_hematopoietic_system_phenotyp1.42047328
48MP0001545_abnormal_hematopoietic_system1.42047328
49MP0002080_prenatal_lethality1.41304658
50MP0002877_abnormal_melanocyte_morpholog1.40026919
51MP0003436_decreased_susceptibility_to1.39933332
52MP0010030_abnormal_orbit_morphology1.39127042
53MP0005023_abnormal_wound_healing1.37245966
54MP0002161_abnormal_fertility/fecundity1.34746346
55MP0000733_abnormal_muscle_development1.33490334
56MP0002138_abnormal_hepatobiliary_system1.31413997
57MP0003718_maternal_effect1.30981763
58MP0000490_abnormal_crypts_of1.30713804
59MP0001915_intracranial_hemorrhage1.29886084
60MP0003123_paternal_imprinting1.25206374
61MP0002139_abnormal_hepatobiliary_system1.24061183
62MP0005360_urolithiasis1.23131611
63MP0003303_peritoneal_inflammation1.20035665
64MP0004264_abnormal_extraembryonic_tissu1.18245222
65MP0008058_abnormal_DNA_repair1.16813741
66MP0009840_abnormal_foam_cell1.16247806
67MP0004130_abnormal_muscle_cell1.15462225
68MP0003567_abnormal_fetal_cardiomyocyte1.15296154
69MP0000537_abnormal_urethra_morphology1.12963673
70MP0002019_abnormal_tumor_incidence1.11831836
71MP0003890_abnormal_embryonic-extraembry1.11698780
72MP0010234_abnormal_vibrissa_follicle1.11285301
73MP0001293_anophthalmia1.10775777
74MP0005257_abnormal_intraocular_pressure1.09725031
75MP0003699_abnormal_female_reproductive1.09442306
76MP0008932_abnormal_embryonic_tissue1.09428148
77MP0001873_stomach_inflammation1.08461810
78MP0003786_premature_aging1.08444430
79MP0002697_abnormal_eye_size1.07959844
80MP0009672_abnormal_birth_weight1.07567477
81MP0002210_abnormal_sex_determination1.06030127
82MP0005666_abnormal_adipose_tissue1.05623943
83MP0000313_abnormal_cell_death1.03904272
84MP0005365_abnormal_bile_salt1.01856881
85MP0002254_reproductive_system_inflammat1.00425511
86MP0002092_abnormal_eye_morphology0.99930384
87MP0004233_abnormal_muscle_weight0.99714539
88MP0000703_abnormal_thymus_morphology0.98429845
89MP0003252_abnormal_bile_duct0.98084574
90MP0000428_abnormal_craniofacial_morphol0.97338164
91MP0003119_abnormal_digestive_system0.97048849
92MP0009703_decreased_birth_body0.94569199
93MP0002925_abnormal_cardiovascular_devel0.91602373
94MP0004381_abnormal_hair_follicle0.90659530
95MP0003453_abnormal_keratinocyte_physiol0.89771634
96MP0000003_abnormal_adipose_tissue0.89664722
97MP0009333_abnormal_splenocyte_physiolog0.89229733
98MP0005085_abnormal_gallbladder_physiolo0.88850563
99MP0003806_abnormal_nucleotide_metabolis0.88797930
100MP0002653_abnormal_ependyma_morphology0.88500517
101MP0009115_abnormal_fat_cell0.87698933
102MP0005379_endocrine/exocrine_gland_phen0.87335879
103MP0003942_abnormal_urinary_system0.85485338
104MP0008770_decreased_survivor_rate0.85048042
105MP0002111_abnormal_tail_morphology0.84820270
106MP0002398_abnormal_bone_marrow0.84537669
107MP0002722_abnormal_immune_system0.83904053
108MP0004858_abnormal_nervous_system0.83869723
109MP0003938_abnormal_ear_development0.83596576
110MP0003091_abnormal_cell_migration0.82983679
111MP0005394_taste/olfaction_phenotype0.82216416
112MP0005499_abnormal_olfactory_system0.82216416
113MP0000477_abnormal_intestine_morphology0.81252834
114MP0010630_abnormal_cardiac_muscle0.80704359
115MP0001145_abnormal_male_reproductive0.79050531
116MP0003115_abnormal_respiratory_system0.78882347
117MP0000858_altered_metastatic_potential0.78666481
118MP0008877_abnormal_DNA_methylation0.78543240
119MP0005671_abnormal_response_to0.77975810
120MP0000432_abnormal_head_morphology0.77959806
121MP0000598_abnormal_liver_morphology0.77771458
122MP0000609_abnormal_liver_physiology0.77504240
123MP0000689_abnormal_spleen_morphology0.77218978
124MP0008961_abnormal_basal_metabolism0.76090616
125MP0005621_abnormal_cell_physiology0.75391543
126MP0005409_darkened_coat_color0.74987198
127MP0003935_abnormal_craniofacial_develop0.74637840
128MP0003763_abnormal_thymus_physiology0.74569411
129MP0005083_abnormal_biliary_tract0.73748849
130MP0000266_abnormal_heart_morphology0.73669822
131MP0003283_abnormal_digestive_organ0.72594073
132MP0003861_abnormal_nervous_system0.71504431
133MP0000569_abnormal_digit_pigmentation0.71257091
134MP0000653_abnormal_sex_gland0.70433763
135MP0009250_abnormal_appendicular_skeleto0.69888692
136MP0004947_skin_inflammation0.69878909
137MP0002249_abnormal_larynx_morphology0.69772708
138MP0005501_abnormal_skin_physiology0.69569901
139MP0002060_abnormal_skin_morphology0.69477068
140MP0000467_abnormal_esophagus_morphology0.69394032
141MP0005375_adipose_tissue_phenotype0.69363062
142MP0003121_genomic_imprinting0.69232919
143MP0000750_abnormal_muscle_regeneration0.68549298
144MP0000685_abnormal_immune_system0.67853907
145MP0005310_abnormal_salivary_gland0.66844891
146MP0000566_synostosis0.66777494
147MP0002429_abnormal_blood_cell0.66509275
148MP0008789_abnormal_olfactory_epithelium0.65460195
149MP0002098_abnormal_vibrissa_morphology0.65236760
150MP0002132_abnormal_respiratory_system0.63932692

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)3.62062715
2Abnormality of DNA repair (HP:0003254)3.43810568
3Ependymoma (HP:0002888)3.41181874
4Ulnar bowing (HP:0003031)3.16283769
5Abnormality of the nasal septum (HP:0000419)3.01341647
6Fatigue (HP:0012378)2.83018077
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74749530
8Synostosis of carpal bones (HP:0005048)2.73319529
9Abnormality of the proximal phalanges of the hand (HP:0009834)2.70180966
10Abnormality of the astrocytes (HP:0100707)2.69403149
11Astrocytoma (HP:0009592)2.69403149
12Hyperacusis (HP:0010780)2.66973684
13Cerebral aneurysm (HP:0004944)2.64326315
14Abnormality of the columella (HP:0009929)2.62990423
15Abnormality of the fingertips (HP:0001211)2.62828839
16Selective tooth agenesis (HP:0001592)2.59835442
17High anterior hairline (HP:0009890)2.57610012
18Abnormality of subcutaneous fat tissue (HP:0001001)2.56030148
19Abnormality of the aortic arch (HP:0012303)2.54816203
20Pseudobulbar signs (HP:0002200)2.53714021
21Volvulus (HP:0002580)2.52747387
22Short 4th metacarpal (HP:0010044)2.52692818
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52692818
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.50842962
25Short 1st metacarpal (HP:0010034)2.50842962
26Morphological abnormality of the middle ear (HP:0008609)2.46987021
27Deviation of the thumb (HP:0009603)2.45920272
28Decreased subcutaneous fat (HP:0001002)2.41736383
29Easy fatigability (HP:0003388)2.41461920
30Difficulty climbing stairs (HP:0003551)2.40550864
31Genu recurvatum (HP:0002816)2.40016579
32Truncus arteriosus (HP:0001660)2.39191904
33Retinal atrophy (HP:0001105)2.38527993
34Megalocornea (HP:0000485)2.38429966
35Proximal placement of thumb (HP:0009623)2.36703963
36Hyperthyroidism (HP:0000836)2.36536850
37Cerebellar dysplasia (HP:0007033)2.36362270
38Neoplasm of the oral cavity (HP:0100649)2.34081973
39Increased nuchal translucency (HP:0010880)2.32606667
40Carpal synostosis (HP:0009702)2.31499623
41Unilateral renal agenesis (HP:0000122)2.31084869
42Heterotopia (HP:0002282)2.26680201
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25920023
44Broad hallux (HP:0010055)2.24983496
45Dislocated radial head (HP:0003083)2.23969894
46Aplasia/Hypoplasia of the thymus (HP:0010515)2.23486946
47Hypoplasia of the pons (HP:0012110)2.23150730
48Rib fusion (HP:0000902)2.22142104
49Prominent nose (HP:0000448)2.20345419
50Hypoparathyroidism (HP:0000829)2.20272287
51Basal cell carcinoma (HP:0002671)2.20002048
52Poikiloderma (HP:0001029)2.19432454
53Long eyelashes (HP:0000527)2.18822341
54Disproportionate tall stature (HP:0001519)2.17822920
55Increased density of long bones (HP:0006392)2.15964489
56Fibular aplasia (HP:0002990)2.15078236
57Abnormality of the 1st metacarpal (HP:0010009)2.13802301
58Facial hemangioma (HP:0000329)2.11046495
59Genetic anticipation (HP:0003743)2.10685263
60Shallow orbits (HP:0000586)2.09671771
61Urethral obstruction (HP:0000796)2.07272114
62Rhabdomyosarcoma (HP:0002859)2.06842162
63Abnormality of cochlea (HP:0000375)2.06591709
64Obstructive sleep apnea (HP:0002870)2.06282382
65Medulloblastoma (HP:0002885)2.05913341
66Abnormality of the radial head (HP:0003995)2.05497442
67Vertebral clefting (HP:0008428)2.05253153
68Abnormality of the 4th metacarpal (HP:0010012)2.04300993
69High pitched voice (HP:0001620)2.03537793
70Short phalanx of the thumb (HP:0009660)2.02488285
71Bell-shaped thorax (HP:0001591)2.01537672
72Stereotypic behavior (HP:0000733)2.01531594
73Osteomalacia (HP:0002749)2.01501300
74Sparse lateral eyebrow (HP:0005338)2.00761738
75Deep palmar crease (HP:0006191)2.00716659
76Obsessive-compulsive behavior (HP:0000722)1.99952133
77Retinal dysplasia (HP:0007973)1.99524656
78Protrusio acetabuli (HP:0003179)1.99445710
79Ectopic kidney (HP:0000086)1.99042703
80Impulsivity (HP:0100710)1.98744982
81Pointed chin (HP:0000307)1.98657117
82Buphthalmos (HP:0000557)1.97564872
83Abnormality of abdominal situs (HP:0011620)1.97004926
84Abdominal situs inversus (HP:0003363)1.97004926
85Renovascular hypertension (HP:0100817)1.96642179
86Neoplasm of striated muscle (HP:0009728)1.96569842
87Spastic diplegia (HP:0001264)1.96501822
88Truncal obesity (HP:0001956)1.95818919
89Bowed forearm bones (HP:0003956)1.95358835
90Bowing of the arm (HP:0006488)1.95358835
91Gastrointestinal carcinoma (HP:0002672)1.93472829
92Malignant gastrointestinal tract tumors (HP:0006749)1.93472829
93Pendular nystagmus (HP:0012043)1.93086053
94Increased mean platelet volume (HP:0011877)1.92157304
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.91046248
96Broad thumb (HP:0011304)1.90371506
97Ankle contracture (HP:0006466)1.89951095
98Abnormal platelet volume (HP:0011876)1.89464442
99Abnormality of the pons (HP:0007361)1.87588813
100Glioma (HP:0009733)1.87530434
101Renal duplication (HP:0000075)1.87347080
102Progressive muscle weakness (HP:0003323)1.86254234
103Skin tags (HP:0010609)1.86066854
104Supernumerary bones of the axial skeleton (HP:0009144)1.85283978
105Hypergonadotropic hypogonadism (HP:0000815)1.85051459
106Vertebral arch anomaly (HP:0008438)1.83462214
107Broad toe (HP:0001837)1.83251822
108Glossoptosis (HP:0000162)1.82805744
109Patellar aplasia (HP:0006443)1.82711626
110Insomnia (HP:0100785)1.82644900
111Myocardial infarction (HP:0001658)1.82491744
112Abnormality of pyrimidine metabolism (HP:0004353)1.81249963
113Synostosis involving bones of the hand (HP:0004278)1.80991113
114Rectal prolapse (HP:0002035)1.80770678
115Bowel incontinence (HP:0002607)1.80023169
116Absent epiphyses (HP:0010577)1.79366858
117Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79366858
118Homocystinuria (HP:0002156)1.79276652
119Abnormality of homocysteine metabolism (HP:0010919)1.79276652
120Chromsome breakage (HP:0040012)1.78360276
121Biliary tract neoplasm (HP:0100574)1.77377488
122Patellar dislocation (HP:0002999)1.76981673
123Abnormality of the costochondral junction (HP:0000919)1.74956156
124Abnormality of the parathyroid morphology (HP:0011766)1.74514572
125Entropion (HP:0000621)1.74233133
126Sandal gap (HP:0001852)1.74023710
127Increased connective tissue (HP:0009025)1.73568878
128Abnormal number of incisors (HP:0011064)1.73565224
129Abnormality of the labia minora (HP:0012880)1.73323108
130Short femoral neck (HP:0100864)1.73075595
131Multiple enchondromatosis (HP:0005701)1.72610754
132Missing ribs (HP:0000921)1.72470453
133Hypertensive crisis (HP:0100735)1.72319364
134Abnormality of the middle phalanges of the toes (HP:0010183)1.71242172
135Mitral valve prolapse (HP:0001634)1.71154050
136Abnormality of the thymus (HP:0000777)1.70654509
137Seborrheic dermatitis (HP:0001051)1.70484927
138Squamous cell carcinoma (HP:0002860)1.70412014
139Metaphyseal cupping (HP:0003021)1.70129300
140Slow saccadic eye movements (HP:0000514)1.70118769
141Short thumb (HP:0009778)1.69638843
1422-3 toe syndactyly (HP:0004691)1.69226283
143Abnormality of reticulocytes (HP:0004312)1.69115419
144Skull defect (HP:0001362)1.68750822
145Aneurysm (HP:0002617)1.68342459
146Cafe-au-lait spot (HP:0000957)1.68200286
147Short humerus (HP:0005792)1.68195082
148Aplasia/Hypoplasia of the patella (HP:0006498)1.67607025
149Supernumerary ribs (HP:0005815)1.67521509
150Abnormality of the lower motor neuron (HP:0002366)1.67224119
151Deep venous thrombosis (HP:0002625)1.66982550
152Preauricular skin tag (HP:0000384)1.66467975
153Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64611340
154Elfin facies (HP:0004428)1.62938648
155Aplasia/hypoplasia of the humerus (HP:0006507)1.62758125
156Short 5th finger (HP:0009237)1.62533845
157Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61677131
158Broad palm (HP:0001169)1.60617454
159Abnormality of the Achilles tendon (HP:0005109)1.60443192
160Vertebral fusion (HP:0002948)1.60083683
161Abnormality of the peritoneum (HP:0002585)1.59969175
162Persistence of primary teeth (HP:0006335)1.59511692
163Upper limb amyotrophy (HP:0009129)1.59185014
164Distal upper limb amyotrophy (HP:0007149)1.59185014
165Tibial bowing (HP:0002982)1.58926074
166Hypoplastic ischia (HP:0003175)1.58683220
167Achilles tendon contracture (HP:0001771)1.58236696
168Hand muscle atrophy (HP:0009130)1.58219716
169Anal stenosis (HP:0002025)1.57284223
170Cutis marmorata (HP:0000965)1.57009488
171Absent radius (HP:0003974)1.56744725
172Overlapping toe (HP:0001845)1.55545801
173Limited elbow extension (HP:0001377)1.55348186
174Colon cancer (HP:0003003)1.55291141
175Reticulocytosis (HP:0001923)1.54260268
176Spina bifida occulta (HP:0003298)1.54094872
177Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54046588
178Radial bowing (HP:0002986)1.53775165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.90813157
2SMG13.74783384
3EEF2K3.39370925
4CDC73.24048781
5TRIB33.20714179
6MAP3K103.15090992
7PKN22.96535764
8MAP3K92.88130488
9NEK22.58754147
10PLK42.43517397
11RIPK42.12643613
12LATS12.07845130
13IRAK31.91288582
14STK101.89683852
15RPS6KB21.68523626
16ICK1.68428317
17MAP2K21.66196395
18TTN1.64252025
19CDK41.63787231
20CDK71.63089383
21MTOR1.61415709
22TESK11.58634981
23SIK11.58496320
24PRPF4B1.56236649
25TTK1.52516729
26MAP4K11.49784577
27ALK1.42032737
28WEE11.39310783
29PTK61.39183943
30CDK61.37820201
31LATS21.33899675
32ERN11.33379090
33STK31.33033000
34EPHA21.32283382
35MAP3K81.26481390
36BRD41.26017737
37PDGFRA1.25019229
38CAMK1D1.22837422
39BMX1.21937820
40PAK41.19166300
41CHEK11.16680508
42PDPK11.15663737
43RPS6KA21.15642718
44RPS6KA41.12429736
45RIPK11.11927370
46NEK11.11438178
47PAK21.09122000
48TAOK11.07614605
49AURKB1.06829910
50ATR1.06733461
51LRRK21.06611550
52CHEK21.01389019
53RPS6KL11.00634237
54RPS6KC11.00634237
55PIM10.98239669
56RPS6KA60.96900249
57STK40.93783991
58MAP3K130.93781941
59GRK60.93612333
60SIK20.93142354
61PLK10.91571826
62FLT30.90618282
63AURKA0.90128872
64PASK0.89978094
65FGFR40.88814685
66PDK10.87328903
67DDR20.84887112
68STK380.84565525
69* CDK20.84209400
70KSR20.83009493
71WNK10.82629229
72SCYL20.82613730
73CAMK1G0.82417652
74ATM0.80600454
75PRKD30.78844135
76TSSK60.75538278
77MARK20.75248639
78MAPK110.73965510
79MAP2K30.73268981
80BUB10.72812939
81CDC42BPA0.70157104
82VRK20.70018564
83TESK20.66049563
84MELK0.65444392
85CHUK0.65036194
86PDGFRB0.64955596
87CLK10.62969542
88AKT20.62572098
89GSK3B0.62427674
90TAOK20.61571515
91DYRK30.59643259
92TYRO30.59556057
93PTK20.58276260
94HIPK20.58266465
95CSNK1E0.57853830
96JAK30.57271511
97DMPK0.56801008
98CDK10.55301875
99CDK90.54046084
100MAPK80.53979423
101CSK0.53570527
102MAP3K10.53265773
103RPS6KA10.52317359
104TNK20.51903794
105MAPK100.50758475
106CSF1R0.50568885
107MARK30.49632195
108IKBKB0.49316588
109FGFR10.49072670
110SRPK10.48346350
111PRKD20.48141886
112IRAK40.47815188
113TGFBR10.47268974
114BRAF0.46986111
115MAPK140.46718765
116TYK20.46699060
117ARAF0.46283111
118BRSK20.45132640
119CSNK1D0.43673967
120STK38L0.42319627
121MAPKAPK30.42219237
122STK110.42065433
123CDK80.41285035
124MAPK10.41141136
125MAPK90.41108190
126WNK40.40921995
127PRKDC0.40713758
128MAP3K110.40516487
129DYRK1B0.39303081
130BTK0.38008903
131EPHB10.37565232
132MAP3K60.37203846
133CSNK2A20.36544586
134ACVR1B0.36443729
135PRKAA10.36361289
136MET0.36214870
137AKT10.35739964
138MAP3K70.35391233
139ZAP700.33847069
140PRKG20.33429287
141PRKCH0.31873918
142BRSK10.30628066

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.88765526
2DNA replication_Homo sapiens_hsa030302.78152406
3Mismatch repair_Homo sapiens_hsa034302.41846803
4Spliceosome_Homo sapiens_hsa030402.36497816
5RNA transport_Homo sapiens_hsa030132.30629561
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25037050
7Type II diabetes mellitus_Homo sapiens_hsa049302.14802169
8Lysine degradation_Homo sapiens_hsa003102.04123439
9Cell cycle_Homo sapiens_hsa041101.97776419
10mRNA surveillance pathway_Homo sapiens_hsa030151.85683629
11Base excision repair_Homo sapiens_hsa034101.69789974
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64452588
13Chronic myeloid leukemia_Homo sapiens_hsa052201.63961264
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61807313
15Small cell lung cancer_Homo sapiens_hsa052221.54506926
16MicroRNAs in cancer_Homo sapiens_hsa052061.51016924
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47184727
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.46786855
19Nitrogen metabolism_Homo sapiens_hsa009101.42382296
20Selenocompound metabolism_Homo sapiens_hsa004501.41505810
21Systemic lupus erythematosus_Homo sapiens_hsa053221.39485080
22Viral carcinogenesis_Homo sapiens_hsa052031.38502112
23T cell receptor signaling pathway_Homo sapiens_hsa046601.33844668
24p53 signaling pathway_Homo sapiens_hsa041151.30662934
25mTOR signaling pathway_Homo sapiens_hsa041501.29464197
26Notch signaling pathway_Homo sapiens_hsa043301.28314430
27Biosynthesis of amino acids_Homo sapiens_hsa012301.23085563
28Bladder cancer_Homo sapiens_hsa052191.21608020
29Nucleotide excision repair_Homo sapiens_hsa034201.17801223
30Homologous recombination_Homo sapiens_hsa034401.14173540
31Adherens junction_Homo sapiens_hsa045201.14161746
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13316825
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12485280
34Dorso-ventral axis formation_Homo sapiens_hsa043201.10172809
35Acute myeloid leukemia_Homo sapiens_hsa052211.10112925
36Arginine biosynthesis_Homo sapiens_hsa002201.09887398
37HTLV-I infection_Homo sapiens_hsa051661.08705935
38Herpes simplex infection_Homo sapiens_hsa051681.05225571
39Non-small cell lung cancer_Homo sapiens_hsa052231.03345937
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.02796819
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.02001726
42Basal cell carcinoma_Homo sapiens_hsa052171.01700913
43Fanconi anemia pathway_Homo sapiens_hsa034601.00740621
44RNA degradation_Homo sapiens_hsa030180.99282171
45Influenza A_Homo sapiens_hsa051640.96320420
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95830064
47Non-homologous end-joining_Homo sapiens_hsa034500.95772707
48Pancreatic cancer_Homo sapiens_hsa052120.95146024
49Proteoglycans in cancer_Homo sapiens_hsa052050.94884961
50ErbB signaling pathway_Homo sapiens_hsa040120.94431203
51Antigen processing and presentation_Homo sapiens_hsa046120.94384551
52Thyroid cancer_Homo sapiens_hsa052160.91469821
53Hippo signaling pathway_Homo sapiens_hsa043900.90736807
54Insulin signaling pathway_Homo sapiens_hsa049100.89382775
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.88875333
56MAPK signaling pathway_Homo sapiens_hsa040100.88043447
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86563934
58Sulfur relay system_Homo sapiens_hsa041220.84700645
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83733922
60B cell receptor signaling pathway_Homo sapiens_hsa046620.82320847
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81185308
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80864710
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.80512970
64FoxO signaling pathway_Homo sapiens_hsa040680.80324730
65Colorectal cancer_Homo sapiens_hsa052100.79992016
66Prostate cancer_Homo sapiens_hsa052150.79636330
67Apoptosis_Homo sapiens_hsa042100.78521273
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77894069
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77859370
70Insulin resistance_Homo sapiens_hsa049310.75851932
71Hepatitis B_Homo sapiens_hsa051610.75727335
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74812298
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74443606
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.73845153
75TNF signaling pathway_Homo sapiens_hsa046680.73820082
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73256017
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73097193
78Epstein-Barr virus infection_Homo sapiens_hsa051690.73092760
79Osteoclast differentiation_Homo sapiens_hsa043800.72691286
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.72212673
81TGF-beta signaling pathway_Homo sapiens_hsa043500.71758838
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71178733
83Endometrial cancer_Homo sapiens_hsa052130.70951707
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70511877
85Basal transcription factors_Homo sapiens_hsa030220.70342706
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70235033
87Hepatitis C_Homo sapiens_hsa051600.70017931
88Pentose phosphate pathway_Homo sapiens_hsa000300.69555054
89Choline metabolism in cancer_Homo sapiens_hsa052310.69053475
90Viral myocarditis_Homo sapiens_hsa054160.67324364
91Inositol phosphate metabolism_Homo sapiens_hsa005620.67317721
92Estrogen signaling pathway_Homo sapiens_hsa049150.66978310
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66919875
94Focal adhesion_Homo sapiens_hsa045100.66819578
95Primary immunodeficiency_Homo sapiens_hsa053400.64698740
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.64203189
97Fatty acid biosynthesis_Homo sapiens_hsa000610.63767383
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63081093
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62583432
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62454832
101Endocytosis_Homo sapiens_hsa041440.60721388
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.60496165
103HIF-1 signaling pathway_Homo sapiens_hsa040660.60012563
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59687940
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58463268
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58093639
107Legionellosis_Homo sapiens_hsa051340.57979717
108Fructose and mannose metabolism_Homo sapiens_hsa000510.57832282
109AMPK signaling pathway_Homo sapiens_hsa041520.57522819
110Leishmaniasis_Homo sapiens_hsa051400.57486137
111Pathways in cancer_Homo sapiens_hsa052000.56994836
112Melanoma_Homo sapiens_hsa052180.56642762
113Measles_Homo sapiens_hsa051620.55829086
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55711702
115RNA polymerase_Homo sapiens_hsa030200.55376559
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.53772977
117Olfactory transduction_Homo sapiens_hsa047400.52992533
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52777999
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.52251266
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52139797
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52077512
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49855197
123Pyrimidine metabolism_Homo sapiens_hsa002400.49745422
124Toxoplasmosis_Homo sapiens_hsa051450.49555518
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49076070
126Hedgehog signaling pathway_Homo sapiens_hsa043400.49023081
127Folate biosynthesis_Homo sapiens_hsa007900.48949506
128Renal cell carcinoma_Homo sapiens_hsa052110.48804994
129Carbon metabolism_Homo sapiens_hsa012000.47778724
130Glioma_Homo sapiens_hsa052140.47162172
131Prolactin signaling pathway_Homo sapiens_hsa049170.47128938
132Staphylococcus aureus infection_Homo sapiens_hsa051500.47019586
133VEGF signaling pathway_Homo sapiens_hsa043700.46388483
134Amoebiasis_Homo sapiens_hsa051460.45726718
135Complement and coagulation cascades_Homo sapiens_hsa046100.45658323
136Shigellosis_Homo sapiens_hsa051310.45614124

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