ZC3H3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)7.46596526
2proline metabolic process (GO:0006560)7.22210961
3embryonic process involved in female pregnancy (GO:0060136)7.01972952
4replication fork processing (GO:0031297)6.68530151
5positive regulation of protein homooligomerization (GO:0032464)6.04131919
6establishment of apical/basal cell polarity (GO:0035089)6.02105873
7regulation of integrin activation (GO:0033623)6.00622268
8DNA deamination (GO:0045006)5.76923198
9oxidative demethylation (GO:0070989)5.56144236
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.53634426
11regulation of protein homooligomerization (GO:0032462)5.30345958
12mitochondrial DNA metabolic process (GO:0032042)5.21378803
13establishment or maintenance of monopolar cell polarity (GO:0061339)5.11563131
14establishment of monopolar cell polarity (GO:0061162)5.11563131
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.86073710
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.86073710
17mitotic G1 DNA damage checkpoint (GO:0031571)4.72122139
18DNA strand renaturation (GO:0000733)4.69916252
19negative regulation of JAK-STAT cascade (GO:0046426)4.67185885
20histone H4-K12 acetylation (GO:0043983)4.66722120
21embryonic placenta development (GO:0001892)4.49834973
22regulation of translational fidelity (GO:0006450)4.42530957
23mRNA cleavage (GO:0006379)4.36384177
24negative regulation of cell cycle arrest (GO:0071157)4.35427817
25negative regulation of erythrocyte differentiation (GO:0045647)4.30797513
26mitotic G1/S transition checkpoint (GO:0044819)4.26387393
27dosage compensation (GO:0007549)4.24267988
28cellular response to ATP (GO:0071318)4.13562334
29G1 DNA damage checkpoint (GO:0044783)4.03623681
30negative regulation of cell killing (GO:0031342)4.02258137
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02258137
32positive regulation by symbiont of host defense response (GO:0052509)3.97583051
33modulation by symbiont of host defense response (GO:0052031)3.97583051
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97583051
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97583051
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.97583051
37modulation by symbiont of host immune response (GO:0052553)3.97583051
38negative regulation of Ras GTPase activity (GO:0034261)3.95483671
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.94605259
40convergent extension (GO:0060026)3.92960791
41antigen processing and presentation of endogenous antigen (GO:0019883)3.88726549
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87077407
43spliceosomal tri-snRNP complex assembly (GO:0000244)3.85883582
44response to peptidoglycan (GO:0032494)3.85834042
45trophectodermal cell differentiation (GO:0001829)3.85043027
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.83117493
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.83117493
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.83117493
49NIK/NF-kappaB signaling (GO:0038061)3.80881426
50protein retention in ER lumen (GO:0006621)3.78510701
51base-excision repair (GO:0006284)3.77155639
52negative regulation of protein oligomerization (GO:0032460)3.76650828
53GDP-mannose metabolic process (GO:0019673)3.75518551
54viral mRNA export from host cell nucleus (GO:0046784)3.75206427
55glutamine family amino acid biosynthetic process (GO:0009084)3.68013249
56glandular epithelial cell development (GO:0002068)3.66263360
57activation of Rac GTPase activity (GO:0032863)3.66018306
58positive regulation by host of viral transcription (GO:0043923)3.64453226
59detection of bacterium (GO:0016045)3.63602320
60regulation of sister chromatid cohesion (GO:0007063)3.62849091
61formation of translation preinitiation complex (GO:0001731)3.61681534
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59322213
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59281014
64positive regulation of Cdc42 GTPase activity (GO:0043089)3.56946435
65positive regulation of protein oligomerization (GO:0032461)3.56618309
66detection of other organism (GO:0098543)3.54417699
67apoptotic process involved in morphogenesis (GO:0060561)3.50197695
68regulation of interferon-beta biosynthetic process (GO:0045357)3.48138894
69negative regulation of mRNA processing (GO:0050686)3.42029414
70mannose metabolic process (GO:0006013)3.41810321
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41341122
72neutrophil activation involved in immune response (GO:0002283)3.40729434
73regulation of protein oligomerization (GO:0032459)3.40543284
74negative regulation of fatty acid biosynthetic process (GO:0045717)3.38892025
75cellular response to zinc ion (GO:0071294)3.36527430
76DNA integration (GO:0015074)3.36055573
77response to muramyl dipeptide (GO:0032495)3.36031755
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35982620
79intracellular estrogen receptor signaling pathway (GO:0030520)3.34566490
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33568084
81anatomical structure regression (GO:0060033)3.32929795
82pre-miRNA processing (GO:0031054)3.32667617
83regulation of T-helper 2 cell differentiation (GO:0045628)3.32518036
84positive regulation of gamma-delta T cell activation (GO:0046645)3.29612345
85macrophage activation involved in immune response (GO:0002281)3.25420556
86positive regulation of developmental pigmentation (GO:0048087)3.24813766
87nodal signaling pathway (GO:0038092)3.24600047
88leukocyte aggregation (GO:0070486)3.24015022
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23857378
90face development (GO:0060324)3.23444630
91regulation of double-strand break repair via homologous recombination (GO:0010569)3.22604971
92regulation of podosome assembly (GO:0071801)3.22283191
93embryonic camera-type eye development (GO:0031076)3.20866212
94regulation of gene silencing by RNA (GO:0060966)3.18949970
95regulation of posttranscriptional gene silencing (GO:0060147)3.18949970
96regulation of gene silencing by miRNA (GO:0060964)3.18949970
973-UTR-mediated mRNA stabilization (GO:0070935)3.18834388
98germinal center formation (GO:0002467)3.18446664
99columnar/cuboidal epithelial cell development (GO:0002066)3.16717149
100mitochondrial RNA metabolic process (GO:0000959)3.15763999
101positive regulation of receptor recycling (GO:0001921)3.15634649
102DNA demethylation (GO:0080111)3.14457057
103regulation of double-strand break repair (GO:2000779)3.13581426
104regulation of cell size (GO:0008361)3.11928250
105base-excision repair, AP site formation (GO:0006285)3.10139808
106labyrinthine layer development (GO:0060711)3.09753127
107non-recombinational repair (GO:0000726)3.09739916
108double-strand break repair via nonhomologous end joining (GO:0006303)3.09739916
109signal complex assembly (GO:0007172)3.08486972
110meiotic chromosome segregation (GO:0045132)3.07649996
111negative regulation of cell size (GO:0045792)3.07531858
112regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.07196125
113regulation of DNA damage checkpoint (GO:2000001)3.06711438
114telomere maintenance via semi-conservative replication (GO:0032201)3.04533829
115immunoglobulin mediated immune response (GO:0016064)3.04416056
116regulation of leukocyte degranulation (GO:0043300)3.01597634
117termination of RNA polymerase II transcription (GO:0006369)3.01340097
118regulation of mast cell degranulation (GO:0043304)2.99846081
119negative regulation of RNA splicing (GO:0033119)2.98927141
120DNA double-strand break processing (GO:0000729)2.97984308
121regulation of hippo signaling (GO:0035330)2.97775860
122negative regulation of viral release from host cell (GO:1902187)2.97458649
123negative regulation of mRNA metabolic process (GO:1903312)2.97274571
124positive regulation of histone deacetylation (GO:0031065)2.97160568
125detection of external biotic stimulus (GO:0098581)2.95704009
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95014099
127thymic T cell selection (GO:0045061)2.94162876
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92816808
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.92274115
130positive regulation of chromosome segregation (GO:0051984)2.91519607
131protein targeting to lysosome (GO:0006622)2.90611112
132establishment of protein localization to vacuole (GO:0072666)2.90611112
133protein targeting to vacuole (GO:0006623)2.90611112
134cellular zinc ion homeostasis (GO:0006882)2.90126785
135regulation of gamma-delta T cell activation (GO:0046643)2.89786119
136positive thymic T cell selection (GO:0045059)2.89612193
137response to type I interferon (GO:0034340)2.86956679
138cellular response to type I interferon (GO:0071357)2.86787505
139type I interferon signaling pathway (GO:0060337)2.86787505
140regulation of early endosome to late endosome transport (GO:2000641)2.84766623
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84515037
142glial cell migration (GO:0008347)2.84420413
143mitotic sister chromatid segregation (GO:0000070)2.83971610
144respiratory burst (GO:0045730)2.82564115
145maturation of 5.8S rRNA (GO:0000460)2.82437766
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79855574
147cellular response to virus (GO:0098586)2.77184542
148COPI coating of Golgi vesicle (GO:0048205)2.75501531
149Golgi transport vesicle coating (GO:0048200)2.75501531
150modulation by virus of host process (GO:0019054)2.72715463
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69519481
152protein localization to endosome (GO:0036010)2.69274702
153modulation by symbiont of host cellular process (GO:0044068)2.68897502
154regulation of necroptotic process (GO:0060544)2.68178351
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67980018
156response to host immune response (GO:0052572)2.67980018
157regulation of gamma-delta T cell differentiation (GO:0045586)2.66809642
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62888561
159negative regulation of type 2 immune response (GO:0002829)2.61653431
160negative regulation of interleukin-12 production (GO:0032695)2.61421398
161positive regulation of antigen processing and presentation (GO:0002579)2.61019346
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60683300
163response to host (GO:0075136)2.60683300
164response to host defenses (GO:0052200)2.60683300
165negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59813509
166regulation of antigen processing and presentation (GO:0002577)2.59255200
167response to laminar fluid shear stress (GO:0034616)2.58615640
168positive regulation of protein deacetylation (GO:0090312)2.57316419
169regulation of mast cell activation involved in immune response (GO:0033006)2.56755743
170negative regulation of innate immune response (GO:0045824)2.56327758
171detection of biotic stimulus (GO:0009595)2.56120830
172B cell receptor signaling pathway (GO:0050853)2.50983883
173antigen processing and presentation via MHC class Ib (GO:0002475)2.50564468
174regulation of defense response to virus by virus (GO:0050690)2.49569449
175negative regulation of T-helper cell differentiation (GO:0045623)2.49567389
176negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49567389
177glucose 6-phosphate metabolic process (GO:0051156)2.49410378
178Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48690447
179negative regulation of phagocytosis (GO:0050765)2.48002351
180regulation of necrotic cell death (GO:0010939)2.47818242
181defense response to protozoan (GO:0042832)2.47472196
182regulation of regulated secretory pathway (GO:1903305)2.47367920
183regulation of T-helper 1 cell differentiation (GO:0045625)2.46012300
184T cell selection (GO:0045058)2.44570914
185granulocyte activation (GO:0036230)2.43829513
186regulation of type 2 immune response (GO:0002828)2.43825722
187detection of molecule of bacterial origin (GO:0032490)2.43662596
188response to protozoan (GO:0001562)2.42596056
189negative regulation of leukocyte mediated immunity (GO:0002704)2.42306896
190negative regulation of lymphocyte mediated immunity (GO:0002707)2.40738166
191neutrophil activation (GO:0042119)2.40518782
192negative regulation of necroptotic process (GO:0060546)2.38170079
193proline biosynthetic process (GO:0006561)10.0050922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95755851
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.90484049
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.90484049
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.90484049
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86271545
6VDR_21846776_ChIP-Seq_THP-1_Human2.64075280
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55608157
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54910160
9* MYC_22102868_ChIP-Seq_BL_Human2.34264020
10E2F7_22180533_ChIP-Seq_HELA_Human2.21116122
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.18417962
12* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.18094539
13LXR_22292898_ChIP-Seq_THP-1_Human2.13314350
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07633622
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05794211
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00849964
17KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.99190871
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.94931128
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.94189316
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.92477421
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90861723
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.90535853
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.90315437
24POU5F1_16518401_ChIP-PET_MESCs_Mouse1.89255555
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.86633462
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84158076
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.81854599
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80445009
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.78980011
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78949041
31NANOG_21062744_ChIP-ChIP_HESCs_Human1.78824736
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76950762
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.76025502
34* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73135023
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72794962
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69893608
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67912850
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66652037
39* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.64333384
40KDM2B_26808549_Chip-Seq_DND41_Human1.62809355
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61978016
42MAF_26560356_Chip-Seq_TH2_Human1.61168974
43ZNF263_19887448_ChIP-Seq_K562_Human1.61154004
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59401053
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59095094
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55975330
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55628917
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.54991283
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54736740
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53012265
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52267197
52RACK7_27058665_Chip-Seq_MCF-7_Human1.51762512
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51150678
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50230794
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48613393
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48101975
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48045466
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.47689271
59BCL6_27268052_Chip-Seq_Bcells_Human1.47195374
60TCF7_22412390_ChIP-Seq_EML_Mouse1.46857916
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46642671
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46293743
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45228069
64* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45121645
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44061693
66* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43576880
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43526742
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43475992
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.42263196
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42160994
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38026477
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.36276870
73* SMC4_20622854_ChIP-Seq_HELA_Human1.35943735
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35887295
75* NCOR1_26117541_ChIP-Seq_K562_Human1.35793157
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35522456
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34367794
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33769704
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32140457
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.31106253
81SPI1_23127762_ChIP-Seq_K562_Human1.31010682
82* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30962327
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30397408
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29924313
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29647271
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.28592260
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.27766122
88SCL_19346495_ChIP-Seq_HPC-7_Human1.27739173
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25451175
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25130246
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24863037
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24269498
93* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23582090
94KDM5A_27292631_Chip-Seq_BREAST_Human1.23551165
95CREB1_26743006_Chip-Seq_LNCaP_Human1.23229233
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22486457
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.22164217
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21905420
99* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21794824
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.21389224
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.21326429
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19375209
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.19092818
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19069787
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17848389
106PHF8_20622854_ChIP-Seq_HELA_Human1.17539988
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17127380
108SPI1_23547873_ChIP-Seq_NB4_Human1.16339786
109TFEB_21752829_ChIP-Seq_HELA_Human1.15359279
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14787146
111BCOR_27268052_Chip-Seq_Bcells_Human1.14577919
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14065963
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13745771
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13549966
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13143770
116GABP_19822575_ChIP-Seq_HepG2_Human1.12973244
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12391802
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12253743
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.12248222
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12053160
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11581461
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11475901
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11423294
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10910526
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.10847938
126GATA1_19941826_ChIP-Seq_K562_Human1.10693399
127RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10069582
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10020373
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09936386
130KDM2B_26808549_Chip-Seq_K562_Human1.09705288
131YY1_21170310_ChIP-Seq_MESCs_Mouse1.09530516
132* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08696875
133* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08635561
134SPI1_26923725_Chip-Seq_HPCs_Mouse1.08582275
135P68_20966046_ChIP-Seq_HELA_Human1.08538118
136THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08459385
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08411036
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08182366
139P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08107937
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07979247
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07187871
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07162754
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06983122
144* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06933319
145E2F1_20622854_ChIP-Seq_HELA_Human1.06914505
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06688171
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06676454
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06471096
149KAP1_27257070_Chip-Seq_ESCs_Mouse1.05903829
150* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05406182
151UTX_26944678_Chip-Seq_JUKART_Human1.05328205
152* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03510350
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00935277
154YY1_22570637_ChIP-Seq_MALME-3M_Human1.00903830
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00743485
156E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00430566
157GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00237859
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00086707
159TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99235658
160VDR_24763502_ChIP-Seq_THP-1_Human0.98584739
161MAF_26560356_Chip-Seq_TH1_Human0.98032469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.52676053
2MP0009278_abnormal_bone_marrow4.34334297
3MP0003436_decreased_susceptibility_to3.80790232
4MP0003283_abnormal_digestive_organ3.76930163
5MP0005451_abnormal_body_composition3.64761606
6MP0003303_peritoneal_inflammation3.30277279
7MP0005171_absent_coat_pigmentation3.22666015
8MP0004233_abnormal_muscle_weight3.13853115
9MP0002653_abnormal_ependyma_morphology3.03380114
10MP0008260_abnormal_autophagy2.97132195
11MP0010030_abnormal_orbit_morphology2.83391109
12MP0003890_abnormal_embryonic-extraembry2.59539299
13MP0005076_abnormal_cell_differentiation2.45462933
14MP0001835_abnormal_antigen_presentation2.37968726
15MP0010352_gastrointestinal_tract_polyps2.36436427
16MP0002009_preneoplasia2.35810256
17MP0003724_increased_susceptibility_to2.30376163
18MP0009840_abnormal_foam_cell2.28721960
19MP0006072_abnormal_retinal_apoptosis2.26915527
20MP0005025_abnormal_response_to2.24554325
21MP0001545_abnormal_hematopoietic_system2.19756802
22MP0005397_hematopoietic_system_phenotyp2.19756802
23MP0005387_immune_system_phenotype2.17674932
24MP0001790_abnormal_immune_system2.17674932
25MP0002877_abnormal_melanocyte_morpholog2.16312149
26MP0008995_early_reproductive_senescence2.13259463
27MP0002419_abnormal_innate_immunity2.11707522
28MP0010094_abnormal_chromosome_stability2.11369021
29MP0003119_abnormal_digestive_system2.11276378
30MP0003191_abnormal_cellular_cholesterol2.10790519
31MP0004947_skin_inflammation2.10576892
32MP0005000_abnormal_immune_tolerance2.07988338
33MP0004264_abnormal_extraembryonic_tissu2.06975271
34MP0008877_abnormal_DNA_methylation2.01467789
35MP0004957_abnormal_blastocyst_morpholog2.00635323
36MP0001800_abnormal_humoral_immune1.99771125
37MP0003300_gastrointestinal_ulcer1.91023255
38MP0003172_abnormal_lysosome_physiology1.90938838
39MP0009785_altered_susceptibility_to1.89055461
40MP0002723_abnormal_immune_serum1.84049423
41MP0004133_heterotaxia1.79426834
42MP0001819_abnormal_immune_cell1.77074632
43MP0002420_abnormal_adaptive_immunity1.76840054
44MP0002452_abnormal_antigen_presenting1.75826486
45MP0005671_abnormal_response_to1.74623096
46MP0003111_abnormal_nucleus_morphology1.71675776
47MP0010155_abnormal_intestine_physiology1.71130586
48MP0002084_abnormal_developmental_patter1.69778076
49MP0002086_abnormal_extraembryonic_tissu1.67336275
50MP0003786_premature_aging1.64767394
51MP0005464_abnormal_platelet_physiology1.62420706
52MP0001533_abnormal_skeleton_physiology1.61401859
53MP0003453_abnormal_keratinocyte_physiol1.61222645
54MP0005058_abnormal_lysosome_morphology1.61116284
55MP0008058_abnormal_DNA_repair1.59788815
56MP0004510_myositis1.59636430
57MP0003183_abnormal_peptide_metabolism1.59144631
58MP0002148_abnormal_hypersensitivity_rea1.58312246
59MP0004858_abnormal_nervous_system1.56731814
60MP0001697_abnormal_embryo_size1.55633325
61MP0002398_abnormal_bone_marrow1.55280481
62MP0000858_altered_metastatic_potential1.52421223
63MP0002085_abnormal_embryonic_tissue1.51605630
64MP0000462_abnormal_digestive_system1.47913915
65MP0003693_abnormal_embryo_hatching1.45011393
66MP0000716_abnormal_immune_system1.44948902
67MP0004197_abnormal_fetal_growth/weight/1.44641759
68MP0000490_abnormal_crypts_of1.44623359
69MP0001293_anophthalmia1.44535295
70MP0000371_diluted_coat_color1.44241241
71MP0004381_abnormal_hair_follicle1.43882915
72MP0005174_abnormal_tail_pigmentation1.40905121
73MP0001672_abnormal_embryogenesis/_devel1.37500097
74MP0005380_embryogenesis_phenotype1.37500097
75MP0002269_muscular_atrophy1.33706827
76MP0001873_stomach_inflammation1.33438491
77MP0002722_abnormal_immune_system1.30899419
78MP0003077_abnormal_cell_cycle1.30059549
79MP0001845_abnormal_inflammatory_respons1.29032602
80MP0002396_abnormal_hematopoietic_system1.28695222
81MP0002132_abnormal_respiratory_system1.28632206
82MP0002429_abnormal_blood_cell1.28369717
83MP0000678_abnormal_parathyroid_gland1.27722182
84MP0000350_abnormal_cell_proliferation1.23044922
85MP0002249_abnormal_larynx_morphology1.23039362
86MP0000470_abnormal_stomach_morphology1.22413172
87MP0000689_abnormal_spleen_morphology1.20539827
88MP0001730_embryonic_growth_arrest1.18488439
89MP0003045_fibrosis1.18069786
90MP0000579_abnormal_nail_morphology1.16279885
91MP0000639_abnormal_adrenal_gland1.16169630
92MP0010307_abnormal_tumor_latency1.14416000
93MP0008469_abnormal_protein_level1.12557366
94MP0003984_embryonic_growth_retardation1.11735129
95MP0005360_urolithiasis1.10705678
96MP0002998_abnormal_bone_remodeling1.09317920
97MP0002796_impaired_skin_barrier1.09008612
98MP0008932_abnormal_embryonic_tissue1.08332214
99MP0002080_prenatal_lethality1.07910794
100MP0002088_abnormal_embryonic_growth/wei1.07263522
101MP0005501_abnormal_skin_physiology1.02367447
102MP0002019_abnormal_tumor_incidence1.02260706
103MP0000685_abnormal_immune_system1.01126849
104MP0001348_abnormal_lacrimal_gland1.00741220
105MP0005666_abnormal_adipose_tissue0.99335044
106MP0003091_abnormal_cell_migration0.99256680
107MP0005409_darkened_coat_color0.98674403
108MP0003075_altered_response_to0.98291019
109MP0002111_abnormal_tail_morphology0.97645334
110MP0002282_abnormal_trachea_morphology0.96933010
111MP0005075_abnormal_melanosome_morpholog0.95928068
112MP0005083_abnormal_biliary_tract0.91521468
113MP0004808_abnormal_hematopoietic_stem0.90390257
114MP0005220_abnormal_exocrine_pancreas0.89993824
115MP0002139_abnormal_hepatobiliary_system0.89836384
116MP0000465_gastrointestinal_hemorrhage0.89606769
117MP0002693_abnormal_pancreas_physiology0.89447589
118MP0005375_adipose_tissue_phenotype0.88992100
119MP0002075_abnormal_coat/hair_pigmentati0.88893875
120MP0003935_abnormal_craniofacial_develop0.88637680
121MP0003656_abnormal_erythrocyte_physiolo0.86634760
122MP0002932_abnormal_joint_morphology0.86628368
123MP0005390_skeleton_phenotype0.86170036
124MP0003705_abnormal_hypodermis_morpholog0.85843598
125MP0001851_eye_inflammation0.85401209
126MP0002933_joint_inflammation0.85348378
127MP0005670_abnormal_white_adipose0.83890796
128MP0000313_abnormal_cell_death0.83863263
129MP0002405_respiratory_system_inflammati0.83329566
130MP0002970_abnormal_white_adipose0.83146486
131MP0005310_abnormal_salivary_gland0.83110799
132MP0002138_abnormal_hepatobiliary_system0.82271773
133MP0003566_abnormal_cell_adhesion0.81779573
134MP0009931_abnormal_skin_appearance0.81344970
135MP0008961_abnormal_basal_metabolism0.79674210
136MP0003828_pulmonary_edema0.78896956
137MP0009764_decreased_sensitivity_to0.78836684
138MP0001340_abnormal_eyelid_morphology0.77688245
139MP0001944_abnormal_pancreas_morphology0.77244858
140MP0006082_CNS_inflammation0.76535320
141MP0001186_pigmentation_phenotype0.75781513
142MP0002116_abnormal_craniofacial_bone0.75769097
143MP0005253_abnormal_eye_physiology0.75499255
144MP0010234_abnormal_vibrissa_follicle0.75369849
145MP0000015_abnormal_ear_pigmentation0.74564714
146MP0009333_abnormal_splenocyte_physiolog0.74398266
147MP0005166_decreased_susceptibility_to0.73688321
148MP0001145_abnormal_male_reproductive0.73446789
149MP0001324_abnormal_eye_pigmentation0.73210650
150MP0002114_abnormal_axial_skeleton0.72982477
151MP0005621_abnormal_cell_physiology0.72850504
152MP0003329_amyloid_beta_deposits0.72817922
153MP0000516_abnormal_urinary_system0.72465630
154MP0005367_renal/urinary_system_phenotyp0.72465630
155MP0001849_ear_inflammation0.72228462
156MP0008874_decreased_physiological_sensi0.72212174
157MP0001853_heart_inflammation0.72035698
158MP0009115_abnormal_fat_cell0.71951438
159MP0003567_abnormal_fetal_cardiomyocyte0.71800962
160MP0002089_abnormal_postnatal_growth/wei0.71528723
161MP0000609_abnormal_liver_physiology0.71291693
162MP0005266_abnormal_metabolism0.70951722
163MP0002166_altered_tumor_susceptibility0.70682179
164MP0003763_abnormal_thymus_physiology0.69822058
165MP0000477_abnormal_intestine_morphology0.69706367
166MP0003279_aneurysm0.69497473
167MP0003755_abnormal_palate_morphology0.67793507
168MP0003866_abnormal_defecation0.66137461
169MP0000432_abnormal_head_morphology0.63341827
170MP0005391_vision/eye_phenotype0.63249860
171MP0004185_abnormal_adipocyte_glucose0.63135229
172MP0001929_abnormal_gametogenesis0.63069532
173MP0000703_abnormal_thymus_morphology0.62794511
174MP0005023_abnormal_wound_healing0.60421556

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.48525852
2Pustule (HP:0200039)4.52816858
3Eczematoid dermatitis (HP:0000976)4.38178642
4Facial hemangioma (HP:0000329)4.37291045
5Rectal fistula (HP:0100590)4.23559204
6Rectovaginal fistula (HP:0000143)4.23559204
7Male infertility (HP:0003251)4.21995593
8Turricephaly (HP:0000262)4.21229296
9Intestinal fistula (HP:0100819)4.18927796
10Annular pancreas (HP:0001734)4.17754626
11Poikiloderma (HP:0001029)3.95978180
12Ulnar bowing (HP:0003031)3.91622045
13Increased IgM level (HP:0003496)3.90047300
14Urinary glycosaminoglycan excretion (HP:0003541)3.84707937
15Mucopolysacchariduria (HP:0008155)3.84707937
16Concave nail (HP:0001598)3.84699403
17Vaginal fistula (HP:0004320)3.83159404
18Pancreatic islet-cell hyperplasia (HP:0004510)3.82955292
19Large for gestational age (HP:0001520)3.81482211
20Tongue fasciculations (HP:0001308)3.73073095
21Short humerus (HP:0005792)3.64200445
22Intestinal atresia (HP:0011100)3.61763173
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.55746366
24Abnormality of polysaccharide metabolism (HP:0011012)3.55746366
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.55746366
26Hypochromic microcytic anemia (HP:0004840)3.54708004
27Alopecia of scalp (HP:0002293)3.50232024
28Orthostatic hypotension (HP:0001278)3.48872903
29Abnormality of macrophages (HP:0004311)3.46623271
30Dysostosis multiplex (HP:0000943)3.46174351
31Aplasia/hypoplasia of the humerus (HP:0006507)3.43912318
32Muscle fibrillation (HP:0010546)3.42951229
33Recurrent abscess formation (HP:0002722)3.40100637
34Cellulitis (HP:0100658)3.39985787
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.38148830
36Recurrent bacterial skin infections (HP:0005406)3.33568515
37Broad face (HP:0000283)3.31962979
38Vertebral hypoplasia (HP:0008417)3.30274201
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.30274201
40Anteriorly placed anus (HP:0001545)3.25460535
41Dysautonomia (HP:0002459)3.11791070
42Abnormality of endocrine pancreas physiology (HP:0012093)3.04570521
43Abnormality of the pancreatic islet cells (HP:0006476)3.04570521
44Increased IgE level (HP:0003212)2.98956174
45Myositis (HP:0100614)2.98430301
46Obstructive sleep apnea (HP:0002870)2.93563278
47Volvulus (HP:0002580)2.88375918
48Hemorrhage of the eye (HP:0011885)2.86098710
49Chronic obstructive pulmonary disease (HP:0006510)2.83396511
50Obstructive lung disease (HP:0006536)2.83396511
51Mediastinal lymphadenopathy (HP:0100721)2.83202992
52Congenital hip dislocation (HP:0001374)2.81960772
53Cerebral aneurysm (HP:0004944)2.79465090
54Meningitis (HP:0001287)2.79228675
55Coronal craniosynostosis (HP:0004440)2.73909046
56Basal cell carcinoma (HP:0002671)2.73408002
57Abnormality of male internal genitalia (HP:0000022)2.71547502
58Cervical subluxation (HP:0003308)2.69410411
59Recurrent gram-negative bacterial infections (HP:0005420)2.67420823
60Orchitis (HP:0100796)2.65491114
61Growth hormone excess (HP:0000845)2.60744968
62Albinism (HP:0001022)2.60386642
63Absent radius (HP:0003974)2.60208299
64Gastrointestinal inflammation (HP:0004386)2.60131944
65Astrocytoma (HP:0009592)2.58070217
66Abnormality of the astrocytes (HP:0100707)2.58070217
67Gastrointestinal infarctions (HP:0005244)2.56843892
68Colitis (HP:0002583)2.56779194
69Squamous cell carcinoma (HP:0002860)2.56476479
70J-shaped sella turcica (HP:0002680)2.53019699
71Alacrima (HP:0000522)2.50790440
72Increased connective tissue (HP:0009025)2.50736780
73Abnormal hemoglobin (HP:0011902)2.50495444
74Spinal muscular atrophy (HP:0007269)2.48923919
75Gingivitis (HP:0000230)2.47369752
76Polycythemia (HP:0001901)2.47135000
77Vertebral fusion (HP:0002948)2.46755030
78Recurrent fungal infections (HP:0002841)2.46411906
79Joint stiffness (HP:0001387)2.46129935
80Broad alveolar ridges (HP:0000187)2.44124588
81Aplasia involving forearm bones (HP:0009822)2.42013399
82Absent forearm bone (HP:0003953)2.42013399
83Abnormality of the aortic arch (HP:0012303)2.40316263
84Hamartoma (HP:0010566)2.40078096
85Elevated erythrocyte sedimentation rate (HP:0003565)2.39398576
86Agammaglobulinemia (HP:0004432)2.39150208
87Patellar aplasia (HP:0006443)2.37396194
88Hypotelorism (HP:0000601)2.37386611
89Absent thumb (HP:0009777)2.36714747
90Hyperacusis (HP:0010780)2.35337340
91Increased cerebral lipofuscin (HP:0011813)2.34106353
92Short chin (HP:0000331)2.31519255
93Ependymoma (HP:0002888)2.30347423
94Loss of speech (HP:0002371)2.28869357
95Inflammation of the large intestine (HP:0002037)2.27060968
96Cholecystitis (HP:0001082)2.26993426
97Abnormal gallbladder physiology (HP:0012438)2.26993426
98Increased serum ferritin (HP:0003281)2.25684607
99Premature skin wrinkling (HP:0100678)2.25307733
100Abnormality of the lower motor neuron (HP:0002366)2.24100427
101Asymmetric septal hypertrophy (HP:0001670)2.22934231
102Systemic lupus erythematosus (HP:0002725)2.22917467
103Bowing of the arm (HP:0006488)2.22568246
104Bowed forearm bones (HP:0003956)2.22568246
105Hypercortisolism (HP:0001578)2.20362015
106Reticulocytosis (HP:0001923)2.16133844
107Metaphyseal cupping (HP:0003021)2.16131244
108Stridor (HP:0010307)2.15918542
109Thin bony cortex (HP:0002753)2.15918025
110Purpura (HP:0000979)2.15347308
111Hyperinsulinemic hypoglycemia (HP:0000825)2.14820826
112Neoplasm of the oral cavity (HP:0100649)2.13624932
113Distal lower limb amyotrophy (HP:0008944)2.13585975
114Abnormality of glycolipid metabolism (HP:0010969)2.13344202
115Abnormality of liposaccharide metabolism (HP:0010968)2.13344202
116Abnormality of glycosphingolipid metabolism (HP:0004343)2.13344202
117Easy fatigability (HP:0003388)2.12890148
118Hypertensive crisis (HP:0100735)2.12771842
119Retrobulbar optic neuritis (HP:0100654)2.12291180
120Optic neuritis (HP:0100653)2.12291180
121Aplasia/Hypoplasia of the patella (HP:0006498)2.11782960
122Prolonged bleeding time (HP:0003010)2.10939281
123Recurrent viral infections (HP:0004429)2.10399754
124Hypochromic anemia (HP:0001931)2.10005772
125Selective tooth agenesis (HP:0001592)2.08927649
126Increased neuronal autofluorescent lipopigment (HP:0002074)2.08781516
127Diaphragmatic weakness (HP:0009113)2.06946786
128Premature graying of hair (HP:0002216)2.06630536
129Gastrointestinal stroma tumor (HP:0100723)2.06439919
130Recurrent skin infections (HP:0001581)2.06257851
131Petechiae (HP:0000967)2.06232089
132Hypertriglyceridemia (HP:0002155)2.05841740
133Polygenic inheritance (HP:0010982)2.05632393
134Urticaria (HP:0001025)2.05265887
135Clumsiness (HP:0002312)2.04959480
136Short 5th finger (HP:0009237)2.04729340
137IgA deficiency (HP:0002720)2.04377886
138Split hand (HP:0001171)2.04284557
139Hepatosplenomegaly (HP:0001433)2.04030728
140Vasculitis (HP:0002633)2.01391834
141Choanal stenosis (HP:0000452)1.99564112
142Emphysema (HP:0002097)1.99491680
143Acute lymphatic leukemia (HP:0006721)1.98399116
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.97295805
145Gastrointestinal atresia (HP:0002589)1.97125768
146Osteomyelitis (HP:0002754)1.96740282
147Disproportionate tall stature (HP:0001519)1.96576437
148Panhypogammaglobulinemia (HP:0003139)1.96231639
149Distal upper limb amyotrophy (HP:0007149)1.94087993
150Upper limb amyotrophy (HP:0009129)1.94087993
151Decreased lacrimation (HP:0000633)1.92725178
152Capillary hemangiomas (HP:0005306)1.91594765
153Hypotrichosis (HP:0001006)1.90332509
154Abnormality of the fingertips (HP:0001211)1.89945600
155Epistaxis (HP:0000421)1.88783302
156Flat acetabular roof (HP:0003180)1.87635537
157Distal lower limb muscle weakness (HP:0009053)1.87467701
158Sepsis (HP:0100806)1.87446960
159Achilles tendon contracture (HP:0001771)1.85633603
160Glioma (HP:0009733)1.85421280
161Thoracic kyphosis (HP:0002942)1.84538578
162Cheilitis (HP:0100825)1.84248266
163Chest pain (HP:0100749)1.83846914
164Abnormality of the labia minora (HP:0012880)1.83154796
165Myopathic facies (HP:0002058)1.82334985
166Abnormality of the thoracic spine (HP:0100711)1.81771827
167Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81742085
168Bifid uvula (HP:0000193)1.81705244
169Long palpebral fissure (HP:0000637)1.81699644
170Malnutrition (HP:0004395)1.80734523
171Encephalitis (HP:0002383)1.80054601
172Verrucae (HP:0200043)1.79738263
173Papilloma (HP:0012740)1.79738263
174Ragged-red muscle fibers (HP:0003200)1.79505908
175Generalized amyotrophy (HP:0003700)1.79459866
176Tented upper lip vermilion (HP:0010804)1.78014338
177Amelogenesis imperfecta (HP:0000705)1.77668961
178Shawl scrotum (HP:0000049)1.77625383
179Broad thumb (HP:0011304)1.77621578
180Lower limb hyperreflexia (HP:0002395)1.77612973
181Popliteal pterygium (HP:0009756)1.77093006
182Slow saccadic eye movements (HP:0000514)1.76568891
183Abnormal delayed hypersensitivity skin test (HP:0002963)1.74648483
184Bulbar palsy (HP:0001283)1.74510494
185Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74031561
186Segmental peripheral demyelination/remyelination (HP:0003481)1.74005797
187Amyloidosis (HP:0011034)1.73195412
188Abnormality of iron homeostasis (HP:0011031)1.73045357
189Gastrointestinal dysmotility (HP:0002579)1.72959282
190Deep venous thrombosis (HP:0002625)1.71553274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.02904105
2MAPK155.34701212
3DDR24.23054730
4MAP3K63.91201385
5TYRO33.00484913
6SMG12.91989032
7MAP3K112.90680670
8MATK2.63807506
9PINK12.49230771
10TESK22.46868209
11IRAK32.36455662
12PRKD22.33609552
13CDK122.32884469
14FGR2.29978091
15PDGFRA2.29064697
16CSK2.12661740
17DYRK1B2.12524489
18DAPK12.11033283
19IRAK42.05109349
20BMX2.04483879
21RIPK42.04189760
22UHMK12.03205119
23MAP2K31.89715832
24CDK71.72355748
25MAP3K101.66840121
26YES11.62974890
27EPHB11.58735913
28PIM21.57362674
29TESK11.56019343
30TBK11.54192397
31TYK21.49192651
32TNK21.47858651
33HIPK21.42234653
34NME21.42210660
35AKT31.41836346
36SIK31.39479459
37CDC42BPA1.37945615
38PKN21.36257109
39MAP3K31.31911749
40ERN11.31606143
41TRIB31.25407311
42PIM11.24807226
43ZAP701.20236055
44CDK61.20194684
45MAP3K11.19552232
46FGFR41.18657326
47MAPK111.17425673
48TRPM71.16762640
49MAP3K131.10374877
50BLK1.09523783
51RPS6KC11.07884605
52RPS6KL11.07884605
53PTK61.07523409
54LATS21.06833677
55MAP3K141.06716473
56CHEK21.06708786
57MTOR1.05848577
58KSR21.01911765
59JAK31.00133975
60GSK3A0.98289892
61KDR0.96824285
62TTN0.94020024
63BTK0.92696265
64RPS6KA60.92653569
65PRKD30.90719222
66PASK0.89752118
67ARAF0.88311319
68IRAK20.88296197
69IKBKE0.85899023
70RPS6KA20.85558935
71NEK20.82255299
72PRKAA10.80776591
73PLK10.79642280
74DYRK30.79032962
75FES0.78804372
76PDPK10.76398173
77HCK0.75775518
78EPHA20.74138262
79MAP2K20.73249188
80PRPF4B0.72878576
81CSF1R0.72562232
82IKBKB0.72390882
83INSRR0.69235067
84TAOK10.68985512
85PTK20.67119299
86FLT30.66802633
87MST1R0.65520376
88RPS6KA10.64066906
89TAOK20.62470809
90MAP3K80.62211114
91RIPK10.58750545
92ATR0.57378308
93MAP3K70.57228011
94CDK20.54590723
95ALK0.54328823
96PDK10.53809199
97BRAF0.53248925
98MAPK120.52699933
99LRRK20.52231927
100MUSK0.51475360
101MAP4K10.51264649
102STK100.51034163
103RPS6KB20.50785288
104LCK0.49333242
105PHKG20.49246315
106PHKG10.49246315
107SYK0.49105879
108MARK20.48925781
109MAPK70.48106294
110SIK10.46187394
111PDGFRB0.45701776
112KIT0.45664720
113MARK30.43332027
114JAK10.42607970
115MAPK10.42216761
116CHEK10.42123204
117MAPK40.40961974
118EGFR0.40942096
119PRKG20.40811917
120BRD40.39744790
121MAPK140.39499750
122EEF2K0.39306011
123MAPKAPK30.39223112
124MAP3K90.39178411
125RAF10.39162291
126RPS6KB10.37298729
127IRAK10.37003134
128LYN0.36649337
129ATM0.36116082
130TTK0.36004293
131MAPK30.35579152
132CHUK0.34370019
133LATS10.33434616
134MAPK100.33110213
135TAOK30.32838623
136STK380.32611830
137STK30.32068074
138CDK40.31702191
139PRKCI0.29617768
140PAK40.29275943
141CDK80.28735614
142CDC70.28619715
143PRKAA20.26772884
144AURKA0.26771729
145MAPKAPK20.26730577
146GRK60.26295236
147CDK10.26291913
148JAK20.25677138
149SCYL20.25310432
150CSNK2A10.24363902
151SIK20.23689300
152GSK3B0.22404576
153AKT10.22115539
154AURKB0.20472016

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.19855046
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.15429011
3Base excision repair_Homo sapiens_hsa034104.02088418
4Mismatch repair_Homo sapiens_hsa034303.95112972
5DNA replication_Homo sapiens_hsa030302.86489891
6Other glycan degradation_Homo sapiens_hsa005112.64386976
7mTOR signaling pathway_Homo sapiens_hsa041502.49391907
8Notch signaling pathway_Homo sapiens_hsa043302.29480728
9Osteoclast differentiation_Homo sapiens_hsa043802.21870855
10Circadian rhythm_Homo sapiens_hsa047102.19774458
11Leishmaniasis_Homo sapiens_hsa051401.98762629
12mRNA surveillance pathway_Homo sapiens_hsa030151.95948151
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92655101
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.77570419
15Adherens junction_Homo sapiens_hsa045201.74191183
16RNA transport_Homo sapiens_hsa030131.72807650
17Hedgehog signaling pathway_Homo sapiens_hsa043401.72214528
18Nucleotide excision repair_Homo sapiens_hsa034201.70470276
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69603666
20Hippo signaling pathway_Homo sapiens_hsa043901.64362920
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.62274845
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.60953445
23Spliceosome_Homo sapiens_hsa030401.59216139
24Lysine degradation_Homo sapiens_hsa003101.59009345
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58652129
26p53 signaling pathway_Homo sapiens_hsa041151.55870736
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.49767649
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49118563
29Staphylococcus aureus infection_Homo sapiens_hsa051501.47388779
30Bladder cancer_Homo sapiens_hsa052191.46799757
31Cell cycle_Homo sapiens_hsa041101.45357167
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44230681
33Tuberculosis_Homo sapiens_hsa051521.43211938
34Fructose and mannose metabolism_Homo sapiens_hsa000511.42116833
35Fanconi anemia pathway_Homo sapiens_hsa034601.40982031
36Non-small cell lung cancer_Homo sapiens_hsa052231.39400676
37Hepatitis C_Homo sapiens_hsa051601.39195390
38Influenza A_Homo sapiens_hsa051641.37795585
39TNF signaling pathway_Homo sapiens_hsa046681.35048307
40Folate biosynthesis_Homo sapiens_hsa007901.34240366
41Homologous recombination_Homo sapiens_hsa034401.33528600
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32696071
43Pentose phosphate pathway_Homo sapiens_hsa000301.32410092
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30802719
45Toxoplasmosis_Homo sapiens_hsa051451.29401055
46Arginine and proline metabolism_Homo sapiens_hsa003301.23313725
47Malaria_Homo sapiens_hsa051441.22481053
48T cell receptor signaling pathway_Homo sapiens_hsa046601.19293043
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18986771
50Allograft rejection_Homo sapiens_hsa053301.17033813
51Measles_Homo sapiens_hsa051621.16255957
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14049408
53Graft-versus-host disease_Homo sapiens_hsa053321.13616553
54VEGF signaling pathway_Homo sapiens_hsa043701.12578448
55Biosynthesis of amino acids_Homo sapiens_hsa012301.12376158
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.11953764
57Galactose metabolism_Homo sapiens_hsa000521.11286893
58Dorso-ventral axis formation_Homo sapiens_hsa043201.09837857
59Apoptosis_Homo sapiens_hsa042101.09431989
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.09428203
61Wnt signaling pathway_Homo sapiens_hsa043101.08841468
62Salmonella infection_Homo sapiens_hsa051321.08224094
63Colorectal cancer_Homo sapiens_hsa052101.06367224
64TGF-beta signaling pathway_Homo sapiens_hsa043501.05618576
65Prion diseases_Homo sapiens_hsa050201.05218782
66Chemokine signaling pathway_Homo sapiens_hsa040621.04843944
67Chronic myeloid leukemia_Homo sapiens_hsa052201.03749478
68Basal cell carcinoma_Homo sapiens_hsa052171.00840868
69Autoimmune thyroid disease_Homo sapiens_hsa053200.99674942
70Sulfur relay system_Homo sapiens_hsa041220.99340557
71Shigellosis_Homo sapiens_hsa051310.99286085
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.99207488
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.99083019
74Primary immunodeficiency_Homo sapiens_hsa053400.98484770
75Pertussis_Homo sapiens_hsa051330.95794722
76Renal cell carcinoma_Homo sapiens_hsa052110.94691836
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.94630216
78Acute myeloid leukemia_Homo sapiens_hsa052210.91967608
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91034741
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90499063
81MicroRNAs in cancer_Homo sapiens_hsa052060.89397486
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88717686
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87290872
84Oocyte meiosis_Homo sapiens_hsa041140.86844796
85Hematopoietic cell lineage_Homo sapiens_hsa046400.83794219
86Selenocompound metabolism_Homo sapiens_hsa004500.82687720
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82424357
88Antigen processing and presentation_Homo sapiens_hsa046120.81851190
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.78767991
90AMPK signaling pathway_Homo sapiens_hsa041520.77937247
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.77338750
92Insulin signaling pathway_Homo sapiens_hsa049100.76774089
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.76021497
94Phagosome_Homo sapiens_hsa041450.75689984
95African trypanosomiasis_Homo sapiens_hsa051430.75224097
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73292082
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73140458
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73097309
99Legionellosis_Homo sapiens_hsa051340.72441108
100Choline metabolism in cancer_Homo sapiens_hsa052310.71657741
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71324940
102Thyroid cancer_Homo sapiens_hsa052160.71233917
103Lysosome_Homo sapiens_hsa041420.71232833
104Viral carcinogenesis_Homo sapiens_hsa052030.70502740
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69868999
106Amoebiasis_Homo sapiens_hsa051460.69722140
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69186922
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67459899
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67122574
110Fatty acid metabolism_Homo sapiens_hsa012120.65327877
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.65071334
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64706520
113Inositol phosphate metabolism_Homo sapiens_hsa005620.64530274
114N-Glycan biosynthesis_Homo sapiens_hsa005100.64130242
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63521546
116ErbB signaling pathway_Homo sapiens_hsa040120.63148397
117Endometrial cancer_Homo sapiens_hsa052130.62971715
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58658299
119GnRH signaling pathway_Homo sapiens_hsa049120.58528644
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56582167
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56244426
122FoxO signaling pathway_Homo sapiens_hsa040680.54979619
123Small cell lung cancer_Homo sapiens_hsa052220.54387600
124HIF-1 signaling pathway_Homo sapiens_hsa040660.54195819
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53674304
126Glioma_Homo sapiens_hsa052140.53011990
127Type I diabetes mellitus_Homo sapiens_hsa049400.52962694
128Type II diabetes mellitus_Homo sapiens_hsa049300.52231613
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.51391969
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51308170
131Pancreatic cancer_Homo sapiens_hsa052120.51113019
132Prolactin signaling pathway_Homo sapiens_hsa049170.50216734
133Herpes simplex infection_Homo sapiens_hsa051680.49573433
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48887332
135HTLV-I infection_Homo sapiens_hsa051660.47832335
136Tight junction_Homo sapiens_hsa045300.47817385
137Hepatitis B_Homo sapiens_hsa051610.47363436
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46804186
139B cell receptor signaling pathway_Homo sapiens_hsa046620.46525823
140Gap junction_Homo sapiens_hsa045400.45005947
141Glucagon signaling pathway_Homo sapiens_hsa049220.43185264
142Viral myocarditis_Homo sapiens_hsa054160.43176192
143One carbon pool by folate_Homo sapiens_hsa006700.42776763
144Endocytosis_Homo sapiens_hsa041440.42057390
145Estrogen signaling pathway_Homo sapiens_hsa049150.41999054
146MAPK signaling pathway_Homo sapiens_hsa040100.41480446
147Proteoglycans in cancer_Homo sapiens_hsa052050.41158160
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40722956
149RNA degradation_Homo sapiens_hsa030180.39459057
150Prostate cancer_Homo sapiens_hsa052150.38078890
151Insulin resistance_Homo sapiens_hsa049310.37836020
152Insulin secretion_Homo sapiens_hsa049110.34938187
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33374197
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31441296
155Basal transcription factors_Homo sapiens_hsa030220.30400566
156Epstein-Barr virus infection_Homo sapiens_hsa051690.29199269
157Pathways in cancer_Homo sapiens_hsa052000.27517085

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