ZC3H4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)6.18034573
2pre-miRNA processing (GO:0031054)4.48381505
3positive regulation of histone deacetylation (GO:0031065)4.22453771
4nuclear pore complex assembly (GO:0051292)4.04765775
5IMP biosynthetic process (GO:0006188)3.93640163
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.84888667
7regulation of histone H3-K27 methylation (GO:0061085)3.82881784
8activated T cell proliferation (GO:0050798)3.82578139
9urate metabolic process (GO:0046415)3.75674776
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73839303
11negative regulation of histone methylation (GO:0031061)3.67696827
12purine-containing compound salvage (GO:0043101)3.67147592
13RNA stabilization (GO:0043489)3.66604338
14mRNA stabilization (GO:0048255)3.66604338
15DNA deamination (GO:0045006)3.64469995
16negative regulation of viral release from host cell (GO:1902187)3.64115123
17mitotic sister chromatid cohesion (GO:0007064)3.61176162
18nuclear pore organization (GO:0006999)3.59570832
19positive regulation of gene expression, epigenetic (GO:0045815)3.58405914
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55028148
21glucocorticoid receptor signaling pathway (GO:0042921)3.51821411
22T cell lineage commitment (GO:0002360)3.50824049
23histone H3-K36 demethylation (GO:0070544)3.45108218
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.42478422
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42478422
26DNA unwinding involved in DNA replication (GO:0006268)3.40625995
27intracellular estrogen receptor signaling pathway (GO:0030520)3.39771995
28NAD biosynthetic process (GO:0009435)3.37392918
29positive regulation of gamma-delta T cell activation (GO:0046645)3.36262793
30protein localization to kinetochore (GO:0034501)3.35484543
31histone H3-K4 methylation (GO:0051568)3.34995354
32negative regulation of RNA splicing (GO:0033119)3.34660599
33heterochromatin organization (GO:0070828)3.25564736
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.24955047
35sister chromatid segregation (GO:0000819)3.24229883
36dosage compensation (GO:0007549)3.23719694
37cytoplasmic mRNA processing body assembly (GO:0033962)3.20281863
38regulation of RNA export from nucleus (GO:0046831)3.20085247
39negative regulation of mRNA processing (GO:0050686)3.19891910
40regulation of translational fidelity (GO:0006450)3.19607990
41nucleosome disassembly (GO:0006337)3.19452945
42protein-DNA complex disassembly (GO:0032986)3.19452945
43regulation of gamma-delta T cell differentiation (GO:0045586)3.18813546
44DNA replication-dependent nucleosome assembly (GO:0006335)3.17647853
45DNA replication-dependent nucleosome organization (GO:0034723)3.17647853
46regulation of B cell apoptotic process (GO:0002902)3.13755160
47viral mRNA export from host cell nucleus (GO:0046784)3.12008085
48regulation of histone H3-K9 methylation (GO:0051570)3.11978034
49negative regulation of histone acetylation (GO:0035067)3.09828628
50pore complex assembly (GO:0046931)3.08606743
51positive regulation of RNA splicing (GO:0033120)3.08123679
52dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.06468164
53chromatin assembly (GO:0031497)3.06270110
54negative regulation of peptidyl-lysine acetylation (GO:2000757)3.05638773
55IMP metabolic process (GO:0046040)3.05585896
56negative regulation of mRNA metabolic process (GO:1903312)3.05390842
57positive regulation of protein deacetylation (GO:0090312)3.04668130
58histone H3-K4 trimethylation (GO:0080182)3.04181013
59UDP-N-acetylglucosamine metabolic process (GO:0006047)3.03064093
60corticosteroid receptor signaling pathway (GO:0031958)3.01509498
61negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.99322801
62nucleotide-sugar biosynthetic process (GO:0009226)2.97377480
63positive thymic T cell selection (GO:0045059)2.95978760
64mitotic sister chromatid segregation (GO:0000070)2.95110936
65protein localization to chromosome, centromeric region (GO:0071459)2.94552408
66NLS-bearing protein import into nucleus (GO:0006607)2.90837856
67spermatid nucleus differentiation (GO:0007289)2.89523307
683-UTR-mediated mRNA stabilization (GO:0070935)2.88810193
69DNA duplex unwinding (GO:0032508)2.88789875
70regulation of gamma-delta T cell activation (GO:0046643)2.88180811
71DNA double-strand break processing (GO:0000729)2.87721729
72histone lysine methylation (GO:0034968)2.87706919
73protein homotrimerization (GO:0070207)2.87488103
74DNA geometric change (GO:0032392)2.87427411
75positive regulation of defense response to virus by host (GO:0002230)2.85486713
76cytidine catabolic process (GO:0006216)2.85254889
77cytidine deamination (GO:0009972)2.85254889
78cytidine metabolic process (GO:0046087)2.85254889
79histone H3-K9 demethylation (GO:0033169)2.85007675
80regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.84961890
81DNA synthesis involved in DNA repair (GO:0000731)2.83187189
82cellular response to exogenous dsRNA (GO:0071360)2.82595210
83alternative mRNA splicing, via spliceosome (GO:0000380)2.81246459
84regulation of mRNA stability (GO:0043488)2.80363714
85histone lysine demethylation (GO:0070076)2.80167421
86replication fork processing (GO:0031297)2.80061040
87peptidyl-lysine trimethylation (GO:0018023)2.79777407
88spliceosomal tri-snRNP complex assembly (GO:0000244)2.78890840
89regulation of sister chromatid cohesion (GO:0007063)2.75251270
90DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.75099290
91mitotic chromosome condensation (GO:0007076)2.74645554
92phosphatidylethanolamine biosynthetic process (GO:0006646)2.71747035
93negative regulation of phagocytosis (GO:0050765)2.71491927
94mitotic nuclear envelope disassembly (GO:0007077)2.71361565
95protein sumoylation (GO:0016925)2.70229547
96histone H4-K16 acetylation (GO:0043984)2.69967977
97peptidyl-lysine dimethylation (GO:0018027)2.69812941
98histone demethylation (GO:0016577)2.68371837
99positive T cell selection (GO:0043368)2.66428244
100GMP metabolic process (GO:0046037)2.64884140
101regulation of histone H3-K4 methylation (GO:0051569)2.64848251
102trophectodermal cell differentiation (GO:0001829)2.64429907
103negative regulation of DNA repair (GO:0045738)2.64281616
104histone H4-K12 acetylation (GO:0043983)2.63873669
105thymic T cell selection (GO:0045061)2.63524861
106telomere maintenance via semi-conservative replication (GO:0032201)2.63489268
107regulation of DNA-dependent DNA replication (GO:0090329)2.62855440
108regulation of RNA stability (GO:0043487)2.62751997
109regulation of NFAT protein import into nucleus (GO:0051532)2.61572532
110RNA localization (GO:0006403)2.61245309
111regulation of hippo signaling (GO:0035330)2.60846240
112negative regulation of gene expression, epigenetic (GO:0045814)2.57793360
113regulation of DNA endoreduplication (GO:0032875)2.57647526
114DNA strand elongation involved in DNA replication (GO:0006271)2.57503697
115telomere maintenance via recombination (GO:0000722)2.57391077
116histone methylation (GO:0016571)2.56538702
117double-strand break repair via homologous recombination (GO:0000724)2.56131371
118chromatin silencing (GO:0006342)2.55918165
119negative regulation of protein acetylation (GO:1901984)2.55907035
120nicotinamide nucleotide biosynthetic process (GO:0019359)2.55459906
121pyridine nucleotide biosynthetic process (GO:0019363)2.55459906
122recombinational repair (GO:0000725)2.55418213
123phosphatidylethanolamine metabolic process (GO:0046337)2.55080903
124positive regulation by host of viral transcription (GO:0043923)2.54847937
125DNA packaging (GO:0006323)2.54525901
126pyridine-containing compound biosynthetic process (GO:0072525)2.54491096
127apoptotic process involved in morphogenesis (GO:0060561)2.54244307
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53189079
129histone H3-K9 methylation (GO:0051567)2.52994941
130positive regulation of interferon-alpha production (GO:0032727)2.52586057
131nuclear envelope disassembly (GO:0051081)2.52284256
132membrane disassembly (GO:0030397)2.52284256
133regulation of nucleobase-containing compound transport (GO:0032239)2.52221576
134regulation of interferon-alpha production (GO:0032647)2.51398798
135DNA replication checkpoint (GO:0000076)2.50907765
136positive regulation of mitotic sister chromatid separation (GO:1901970)2.49472717
137positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49472717
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49472717
139positive regulation of chromosome segregation (GO:0051984)2.49241889
140regulation of defense response to virus by host (GO:0050691)2.47982747
141RNA destabilization (GO:0050779)2.47195434
142negative regulation of chromatin modification (GO:1903309)2.45276776
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45017420
144histone H3-K9 modification (GO:0061647)2.44270447
145gene silencing (GO:0016458)2.43307223
146response to UV-C (GO:0010225)2.42574529
147histone mRNA catabolic process (GO:0071044)2.42548869
148natural killer cell differentiation (GO:0001779)2.41333026
149regulation of chromatin binding (GO:0035561)2.40995255
150nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.40816310
151protein demethylation (GO:0006482)2.40812231
152protein dealkylation (GO:0008214)2.40812231
153regulation of histone methylation (GO:0031060)2.40593254
154peptidyl-lysine methylation (GO:0018022)2.39326244
155mitotic G1 DNA damage checkpoint (GO:0031571)2.37879075
156negative regulation of histone modification (GO:0031057)2.37860155
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.37371250
158negative regulation of translation, ncRNA-mediated (GO:0040033)2.37371250
159regulation of translation, ncRNA-mediated (GO:0045974)2.37371250
160regulation of DNA damage checkpoint (GO:2000001)2.36276734
161histone H4-K8 acetylation (GO:0043982)2.36064647
162histone H4-K5 acetylation (GO:0043981)2.36064647
163T cell selection (GO:0045058)2.35342460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00636123
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93252809
3* MYC_22102868_ChIP-Seq_BL_Human4.43113129
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.12046981
5NOTCH1_21737748_ChIP-Seq_TLL_Human4.08591114
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50189943
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.48759756
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35416116
9* VDR_21846776_ChIP-Seq_THP-1_Human3.01199607
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.76191816
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58529736
12KDM2B_26808549_Chip-Seq_DND41_Human2.53226908
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.44407578
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40257700
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39209376
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27259124
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20709905
18SCL_19346495_ChIP-Seq_HPC-7_Human2.12273372
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.12129025
20* UTX_26944678_Chip-Seq_JUKART_Human2.08125735
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05721237
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04688599
23* MAF_26560356_Chip-Seq_TH1_Human2.01439285
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01065184
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98770359
26FOXP3_21729870_ChIP-Seq_TREG_Human1.98022062
27* CIITA_25753668_ChIP-Seq_RAJI_Human1.95336998
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93998978
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.89922767
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.87359313
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76791692
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.75384535
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75214109
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73674055
35* KDM2B_26808549_Chip-Seq_JURKAT_Human1.71568041
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70008176
37VDR_24763502_ChIP-Seq_THP-1_Human1.69355613
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66023179
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.62935781
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62647085
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62171791
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61988018
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60081487
44MYB_26560356_Chip-Seq_TH1_Human1.58056891
45DCP1A_22483619_ChIP-Seq_HELA_Human1.58028108
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57591181
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57172036
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55625514
49* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55273876
50VDR_23849224_ChIP-Seq_CD4+_Human1.55254093
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54415148
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53891656
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53598607
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52144821
55* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50431781
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50217552
57* NCOR1_26117541_ChIP-Seq_K562_Human1.47648745
58* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46242995
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46102464
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45628910
61MYB_26560356_Chip-Seq_TH2_Human1.44261860
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40344505
63* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40334927
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39924380
65SPI1_23127762_ChIP-Seq_K562_Human1.38781313
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38695194
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37603549
68SPI1_23547873_ChIP-Seq_NB4_Human1.36166069
69KDM2B_26808549_Chip-Seq_K562_Human1.35004789
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34876004
71* RUNX1_22412390_ChIP-Seq_EML_Mouse1.34734878
72LXR_22292898_ChIP-Seq_THP-1_Human1.32182725
73* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30154514
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29097870
75TFEB_21752829_ChIP-Seq_HELA_Human1.28948295
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.28890558
77MAF_26560356_Chip-Seq_TH2_Human1.28700517
78GABP_19822575_ChIP-Seq_HepG2_Human1.26966432
79RUNX_20019798_ChIP-Seq_JUKART_Human1.25932038
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25858522
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23301107
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21787286
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.21242427
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21133525
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20537096
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20058565
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19648336
88RACK7_27058665_Chip-Seq_MCF-7_Human1.17281230
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16346321
90* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15272469
91KDM5A_27292631_Chip-Seq_BREAST_Human1.15090408
92GATA3_27048872_Chip-Seq_THYMUS_Human1.14166311
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.13737671
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13486772
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12135762
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10534078
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10389536
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.10319138
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08172369
100* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07599666
101* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06962715
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06887267
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06517280
104* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05324685
105GATA1_19941826_ChIP-Seq_K562_Human1.05280868
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05170326
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05058595
108ELF5_23300383_ChIP-Seq_T47D_Human1.04798425
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03955462
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03580678
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03355338
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02730814
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02291729
114* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01545364
115CREB1_26743006_Chip-Seq_LNCaP_Human1.01132051
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01028822
117* CHD1_26751641_Chip-Seq_LNCaP_Human1.00123657
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99930400
119* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99227413
120* NANOG_21062744_ChIP-ChIP_HESCs_Human0.99126915
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98622886
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98211491
123ATF3_27146783_Chip-Seq_COLON_Human0.97609824
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97500540
125* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97463779
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96960605
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96637095
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95115739
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94791443
130MYC_18555785_ChIP-Seq_MESCs_Mouse0.94744716
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94075937
132GATA6_25053715_ChIP-Seq_YYC3_Human0.93416629
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92412812
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.91973401
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91558186
136TP63_17297297_ChIP-ChIP_HaCaT_Human0.91495880
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91459617
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90261658
139MYC_18940864_ChIP-ChIP_HL60_Human0.89532378
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.89077292
141TP53_22127205_ChIP-Seq_IMR90_Human0.88807449
142ELK1_19687146_ChIP-ChIP_HELA_Human0.87884924
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87600002
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87571501
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.86750860
146P68_20966046_ChIP-Seq_HELA_Human0.85865287
147HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85641219
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85394265
149AR_21909140_ChIP-Seq_LNCAP_Human0.85326503
150* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82674622
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81865860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.52895645
2MP0005076_abnormal_cell_differentiation3.26346899
3MP0010352_gastrointestinal_tract_polyps2.99914495
4MP0003705_abnormal_hypodermis_morpholog2.88743783
5MP0002396_abnormal_hematopoietic_system2.77745859
6MP0009278_abnormal_bone_marrow2.68850215
7MP0003111_abnormal_nucleus_morphology2.54672116
8MP0008057_abnormal_DNA_replication2.50765388
9MP0001348_abnormal_lacrimal_gland2.50085651
10MP0008877_abnormal_DNA_methylation2.48183819
11MP0010234_abnormal_vibrissa_follicle2.32820424
12MP0005310_abnormal_salivary_gland2.30485694
13MP0003300_gastrointestinal_ulcer2.14753994
14MP0004808_abnormal_hematopoietic_stem2.10259769
15MP0003077_abnormal_cell_cycle2.06073294
16MP0010094_abnormal_chromosome_stability2.06053261
17MP0003283_abnormal_digestive_organ2.02516066
18MP0010307_abnormal_tumor_latency1.94242867
19MP0000569_abnormal_digit_pigmentation1.93618189
20MP0001849_ear_inflammation1.87402644
21MP0000613_abnormal_salivary_gland1.85225764
22MP0003303_peritoneal_inflammation1.83536276
23MP0005645_abnormal_hypothalamus_physiol1.80675048
24MP0003950_abnormal_plasma_membrane1.78212039
25MP0005397_hematopoietic_system_phenotyp1.76352158
26MP0001545_abnormal_hematopoietic_system1.76352158
27MP0001346_abnormal_lacrimal_gland1.75383424
28MP0000350_abnormal_cell_proliferation1.73100084
29MP0002090_abnormal_vision1.70483080
30MP0008961_abnormal_basal_metabolism1.69020549
31MP0000372_irregular_coat_pigmentation1.68695135
32MP0000703_abnormal_thymus_morphology1.67861721
33MP0001730_embryonic_growth_arrest1.66862559
34MP0004197_abnormal_fetal_growth/weight/1.64922831
35MP0004381_abnormal_hair_follicle1.64386372
36MP0002398_abnormal_bone_marrow1.62129433
37MP0003763_abnormal_thymus_physiology1.61779801
38MP0000733_abnormal_muscle_development1.61224672
39MP0001672_abnormal_embryogenesis/_devel1.58817604
40MP0005380_embryogenesis_phenotype1.58817604
41MP0003984_embryonic_growth_retardation1.58333630
42MP0002086_abnormal_extraembryonic_tissu1.58151965
43MP0002088_abnormal_embryonic_growth/wei1.55754431
44MP0003693_abnormal_embryo_hatching1.51049295
45MP0005647_abnormal_sex_gland1.50962965
46MP0003566_abnormal_cell_adhesion1.50352402
47MP0002084_abnormal_developmental_patter1.50060470
48MP0005367_renal/urinary_system_phenotyp1.43771728
49MP0000516_abnormal_urinary_system1.43771728
50MP0000490_abnormal_crypts_of1.42604570
51MP0002085_abnormal_embryonic_tissue1.41269910
52MP0001697_abnormal_embryo_size1.38682563
53MP0004957_abnormal_blastocyst_morpholog1.38613108
54MP0010030_abnormal_orbit_morphology1.38110257
55MP0005075_abnormal_melanosome_morpholog1.37502738
56MP0001800_abnormal_humoral_immune1.36260554
57MP0002722_abnormal_immune_system1.34966378
58MP0002925_abnormal_cardiovascular_devel1.32381799
59MP0005451_abnormal_body_composition1.30319733
60MP0008007_abnormal_cellular_replicative1.29463268
61MP0000685_abnormal_immune_system1.29223209
62MP0000015_abnormal_ear_pigmentation1.28896512
63MP0001915_intracranial_hemorrhage1.27715568
64MP0002166_altered_tumor_susceptibility1.24754351
65MP0003786_premature_aging1.24172077
66MP0002877_abnormal_melanocyte_morpholog1.22929068
67MP0005220_abnormal_exocrine_pancreas1.21962006
68MP0003436_decreased_susceptibility_to1.21560395
69MP0004185_abnormal_adipocyte_glucose1.21536768
70MP0000689_abnormal_spleen_morphology1.20706607
71MP0002080_prenatal_lethality1.17696878
72MP0009672_abnormal_birth_weight1.15479413
73MP0009703_decreased_birth_body1.15187104
74MP0000428_abnormal_craniofacial_morphol1.14962442
75MP0000716_abnormal_immune_system1.13979470
76MP0010630_abnormal_cardiac_muscle1.13936053
77MP0005000_abnormal_immune_tolerance1.13719964
78MP0002653_abnormal_ependyma_morphology1.11443445
79MP0003567_abnormal_fetal_cardiomyocyte1.11203400
80MP0003787_abnormal_imprinting1.07739519
81MP0003121_genomic_imprinting1.07059910
82MP0009333_abnormal_splenocyte_physiolog1.06916331
83MP0003935_abnormal_craniofacial_develop1.06310650
84MP0002429_abnormal_blood_cell1.06175460
85MP0009053_abnormal_anal_canal1.04894848
86MP0003866_abnormal_defecation1.03935528
87MP0003890_abnormal_embryonic-extraembry1.03496176
88MP0002019_abnormal_tumor_incidence1.03377908
89MP0000537_abnormal_urethra_morphology1.03337810
90MP0005387_immune_system_phenotype1.03226850
91MP0001790_abnormal_immune_system1.03226850
92MP0002452_abnormal_antigen_presenting1.02431968
93MP0008770_decreased_survivor_rate1.00776492
94MP0000266_abnormal_heart_morphology1.00393521
95MP0002876_abnormal_thyroid_physiology0.99862237
96MP0002420_abnormal_adaptive_immunity0.99137851
97MP0000313_abnormal_cell_death0.98567784
98MP0001919_abnormal_reproductive_system0.98214285
99MP0005023_abnormal_wound_healing0.97966994
100MP0000465_gastrointestinal_hemorrhage0.97963986
101MP0001819_abnormal_immune_cell0.97324570
102MP0002405_respiratory_system_inflammati0.96752422
103MP0003115_abnormal_respiratory_system0.96024020
104MP0002163_abnormal_gland_morphology0.95700138
105MP0003091_abnormal_cell_migration0.95560132
106MP0002249_abnormal_larynx_morphology0.94929694
107MP0002006_tumorigenesis0.94196651
108MP0000678_abnormal_parathyroid_gland0.94180032
109MP0002697_abnormal_eye_size0.92316574
110MP0001929_abnormal_gametogenesis0.91614191
111MP0003943_abnormal_hepatobiliary_system0.90949593
112MP0004264_abnormal_extraembryonic_tissu0.90873825
113MP0002751_abnormal_autonomic_nervous0.90588616
114MP0002092_abnormal_eye_morphology0.90131653
115MP0009785_altered_susceptibility_to0.90113190
116MP0006054_spinal_hemorrhage0.89526017
117MP0001944_abnormal_pancreas_morphology0.89067981
118MP0005464_abnormal_platelet_physiology0.88427734
119MP0001784_abnormal_fluid_regulation0.88360979
120MP0001293_anophthalmia0.88283971
121MP0001661_extended_life_span0.88137477
122MP0002210_abnormal_sex_determination0.87930259
123MP0002938_white_spotting0.87186789
124MP0001873_stomach_inflammation0.87079543
125MP0001835_abnormal_antigen_presentation0.86227035
126MP0001145_abnormal_male_reproductive0.85691766
127MP0005671_abnormal_response_to0.85400464
128MP0002693_abnormal_pancreas_physiology0.85226563
129MP0000003_abnormal_adipose_tissue0.85163037
130MP0010155_abnormal_intestine_physiology0.84175958
131MP0004947_skin_inflammation0.83699280
132MP0003119_abnormal_digestive_system0.83560466
133MP0008058_abnormal_DNA_repair0.83499849
134MP0005410_abnormal_fertilization0.83117891
135MP0002138_abnormal_hepatobiliary_system0.82514830
136MP0002723_abnormal_immune_serum0.82472705
137MP0002009_preneoplasia0.79583510
138MP0009697_abnormal_copulation0.79124658
139MP0002928_abnormal_bile_duct0.79003404
140MP0003172_abnormal_lysosome_physiology0.78411729
141MP0000432_abnormal_head_morphology0.77950659
142MP0000767_abnormal_smooth_muscle0.77623342
143MP0005375_adipose_tissue_phenotype0.77607153
144MP0006292_abnormal_olfactory_placode0.76722575
145MP0002277_abnormal_respiratory_mucosa0.75183794
146MP0003195_calcinosis0.74977062
147MP0000653_abnormal_sex_gland0.73995998
148MP0003938_abnormal_ear_development0.72467339

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)7.30919101
2Increased neuronal autofluorescent lipopigment (HP:0002074)6.47286453
3Autoimmune hemolytic anemia (HP:0001890)6.00542965
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.65401862
5Testicular atrophy (HP:0000029)5.64029126
6Increased cerebral lipofuscin (HP:0011813)5.31631690
7Prostate neoplasm (HP:0100787)5.24378030
8Spastic diplegia (HP:0001264)4.68389066
9Tetraparesis (HP:0002273)4.46799478
10Abnormality of the fingertips (HP:0001211)4.07463925
11Hyperacusis (HP:0010780)3.61448279
12Neoplasm of the adrenal cortex (HP:0100641)3.50257376
13Dyschromatopsia (HP:0007641)3.40957283
14Progressive external ophthalmoplegia (HP:0000590)3.37834277
15Short 4th metacarpal (HP:0010044)3.32854311
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32854311
17Abnormality of T cell physiology (HP:0011840)3.14697597
18Termporal pattern (HP:0011008)3.13592429
19Insidious onset (HP:0003587)3.13592429
20Long eyelashes (HP:0000527)3.04317033
21Lymphopenia (HP:0001888)2.90444289
22Progressive sensorineural hearing impairment (HP:0000408)2.90374839
23Cerebral aneurysm (HP:0004944)2.82604886
24Volvulus (HP:0002580)2.79822024
25Abnormality of the prostate (HP:0008775)2.73382817
26Increased nuchal translucency (HP:0010880)2.65048253
27Abnormality of cells of the lymphoid lineage (HP:0012140)2.63286815
28Abnormality of chromosome segregation (HP:0002916)2.60511845
29Trigonocephaly (HP:0000243)2.54679027
30Macroorchidism (HP:0000053)2.50202724
31Renal duplication (HP:0000075)2.49627406
32Urethral obstruction (HP:0000796)2.47744702
33Abnormality of the 4th metacarpal (HP:0010012)2.46869914
34B lymphocytopenia (HP:0010976)2.42575787
35Ulnar bowing (HP:0003031)2.41925554
36Elfin facies (HP:0004428)2.40495313
37Renovascular hypertension (HP:0100817)2.40202777
38Glioma (HP:0009733)2.39825425
39Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.37499234
40Short 1st metacarpal (HP:0010034)2.37499234
41Increased density of long bones (HP:0006392)2.32257895
42Lymphoma (HP:0002665)2.31619590
43Shallow orbits (HP:0000586)2.28033852
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27396263
45Abnormality of T cells (HP:0002843)2.23489632
46Hamartoma of the eye (HP:0010568)2.23102759
47Abnormality of the 1st metacarpal (HP:0010009)2.21168865
48Asplenia (HP:0001746)2.20339072
49Pendular nystagmus (HP:0012043)2.20179772
50Progressive hearing impairment (HP:0001730)2.19633997
51Prominent nose (HP:0000448)2.19606957
52Pseudobulbar signs (HP:0002200)2.19092437
53Heterotopia (HP:0002282)2.18610134
54Broad palm (HP:0001169)2.16726631
55Rhabdomyosarcoma (HP:0002859)2.15105963
56Abnormality of homocysteine metabolism (HP:0010919)2.11609710
57Homocystinuria (HP:0002156)2.11609710
58Cellulitis (HP:0100658)2.08677576
59Abnormality of B cell number (HP:0010975)2.08426298
60Broad thumb (HP:0011304)2.05871161
61Ependymoma (HP:0002888)2.05814967
62Tented upper lip vermilion (HP:0010804)2.05709948
63Overriding aorta (HP:0002623)2.04759854
64Insomnia (HP:0100785)2.03332547
65Recurrent viral infections (HP:0004429)2.01989292
66Squamous cell carcinoma (HP:0002860)2.00987855
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.00623480
68Central scotoma (HP:0000603)2.00308172
69Deviation of the thumb (HP:0009603)1.99032377
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.98854269
71Skin tags (HP:0010609)1.98339103
72High anterior hairline (HP:0009890)1.97664099
73Astrocytoma (HP:0009592)1.97656137
74Abnormality of the astrocytes (HP:0100707)1.97656137
75Abnormality of male internal genitalia (HP:0000022)1.97546211
76Obsessive-compulsive behavior (HP:0000722)1.96904224
77Vertebral arch anomaly (HP:0008438)1.96463898
78Chromsome breakage (HP:0040012)1.96279292
79Cutis marmorata (HP:0000965)1.96270109
80Abnormality of the intervertebral disk (HP:0005108)1.96231017
81Ectopic kidney (HP:0000086)1.94281163
82Supernumerary ribs (HP:0005815)1.92751759
83Neoplasm of striated muscle (HP:0009728)1.90811327
84Proximal placement of thumb (HP:0009623)1.90462042
85Anal stenosis (HP:0002025)1.87633281
86Bowel diverticulosis (HP:0005222)1.87130927
87Papilloma (HP:0012740)1.86709511
88Verrucae (HP:0200043)1.86709511
89Narrow palate (HP:0000189)1.86177295
90Rib fusion (HP:0000902)1.85722570
91High pitched voice (HP:0001620)1.85345005
92Abnormality of the pancreatic islet cells (HP:0006476)1.84874240
93Abnormality of endocrine pancreas physiology (HP:0012093)1.84874240
94Aqueductal stenosis (HP:0002410)1.84769766
95Basal cell carcinoma (HP:0002671)1.83119361
96Abnormal auditory evoked potentials (HP:0006958)1.82703040
97Disproportionate tall stature (HP:0001519)1.81549466
98Aortic aneurysm (HP:0004942)1.81334428
99Syringomyelia (HP:0003396)1.79551543
100Spinal cord lesions (HP:0100561)1.79551543
101Obstructive sleep apnea (HP:0002870)1.78686868
102Cafe-au-lait spot (HP:0000957)1.77994209
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.77876957
104Hypoplasia of the fovea (HP:0007750)1.77876957
105Subacute progressive viral hepatitis (HP:0006572)1.76955652
106Pointed chin (HP:0000307)1.75839412
107Flat cornea (HP:0007720)1.75520090
108Gastrointestinal inflammation (HP:0004386)1.74769489
109Skull defect (HP:0001362)1.74678890
110Abnormality of the parathyroid morphology (HP:0011766)1.74485901
111Neoplasm of the oral cavity (HP:0100649)1.74452828
112Methylmalonic acidemia (HP:0002912)1.74302614
113Absent frontal sinuses (HP:0002688)1.74187394
114Intestinal fistula (HP:0100819)1.74132767
115Hypoalbuminemia (HP:0003073)1.74060206
116Abnormal albumin level (HP:0012116)1.74060206
117Neoplasm of the adrenal gland (HP:0100631)1.73405326
118Gastrointestinal carcinoma (HP:0002672)1.72268496
119Malignant gastrointestinal tract tumors (HP:0006749)1.72268496
120Conjunctival hamartoma (HP:0100780)1.72262074
121Spina bifida occulta (HP:0003298)1.71586102
122Short 5th finger (HP:0009237)1.70841608
123Genu recurvatum (HP:0002816)1.70687028
124Meningioma (HP:0002858)1.70647033
125Chronic mucocutaneous candidiasis (HP:0002728)1.70294213
126Recurrent cutaneous fungal infections (HP:0011370)1.70294213
127Amaurosis fugax (HP:0100576)1.69887352
128Selective tooth agenesis (HP:0001592)1.69377009
129Abnormal platelet volume (HP:0011876)1.68803064
130Breast carcinoma (HP:0003002)1.67605778
131Colitis (HP:0002583)1.66419451
132Abnormality of purine metabolism (HP:0004352)1.66165174
133Clubbing of toes (HP:0100760)1.66131481
134Truncal obesity (HP:0001956)1.66111623
135Sandal gap (HP:0001852)1.65501188
136Medulloblastoma (HP:0002885)1.65459020
137Abnormality of abdominal situs (HP:0011620)1.64909614
138Abdominal situs inversus (HP:0003363)1.64909614
139Long palpebral fissure (HP:0000637)1.64592106
140Short phalanx of the thumb (HP:0009660)1.64006753
141Unilateral renal agenesis (HP:0000122)1.63961172
142Abnormality of the columella (HP:0009929)1.63789773
143Abnormality of the preputium (HP:0100587)1.63423736
144Recurrent fungal infections (HP:0002841)1.63165934
145Late onset (HP:0003584)1.62969260
146Leiomyosarcoma (HP:0100243)1.62820019
147Uterine leiomyosarcoma (HP:0002891)1.62820019
148Bicuspid aortic valve (HP:0001647)1.62682199
149Meckel diverticulum (HP:0002245)1.62621029
150Broad phalanges of the hand (HP:0009768)1.62431412
151Smooth philtrum (HP:0000319)1.62369122
152Autoimmune thrombocytopenia (HP:0001973)1.62288168
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62194908
154Preauricular skin tag (HP:0000384)1.62094605
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.62059495
156Inflammation of the large intestine (HP:0002037)1.61528044
157Panhypogammaglobulinemia (HP:0003139)1.61419884
158Dislocated radial head (HP:0003083)1.61181491
159Abnormality of the nasal septum (HP:0000419)1.61101530
160Aneurysm (HP:0002617)1.60969544
161Abnormal number of incisors (HP:0011064)1.60954245
162Abnormality of the diencephalon (HP:0010662)1.60818027
163Limited elbow extension (HP:0001377)1.60557099
164Transitional cell carcinoma of the bladder (HP:0006740)1.60179772
165Abnormality of chromosome stability (HP:0003220)1.60164003
166Supernumerary bones of the axial skeleton (HP:0009144)1.60050164
167Prolonged bleeding time (HP:0003010)1.60042152
168Malnutrition (HP:0004395)1.59889391
169Abnormality of the ileum (HP:0001549)1.58727704
170Enlarged penis (HP:0000040)1.57996530
171Cutaneous melanoma (HP:0012056)1.57744148
172Mitral valve prolapse (HP:0001634)1.57210187
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.56966121
174Thick eyebrow (HP:0000574)1.56540922
175Agammaglobulinemia (HP:0004432)1.55973812
176Abnormality of the aortic arch (HP:0012303)1.55858373
177Acute lymphatic leukemia (HP:0006721)1.55706919
178Asymmetry of the thorax (HP:0001555)1.55584200
179Short thumb (HP:0009778)1.55232995
180Ureteral stenosis (HP:0000071)1.54349622
181Deep philtrum (HP:0002002)1.52731479
182Abnormality of the radial head (HP:0003995)1.51107316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.96198224
2SMG14.28782398
3MAP3K104.05023953
4EEF2K3.92394410
5NEK13.32527294
6TRIB33.17501763
7FRK2.94670272
8PKN22.80619013
9VRK22.76556452
10MAP4K12.72612327
11ICK2.23094538
12TAF12.18739714
13MKNK22.15357538
14BUB12.14573466
15CDC72.09917061
16SIK22.07353602
17BRD42.04713613
18TXK2.03577828
19NEK21.89865745
20LATS11.83826003
21CAMK1G1.74476977
22STK101.70035720
23CAMK1D1.68433839
24SIK11.62717015
25ALK1.62463921
26PTK61.61924256
27EIF2AK31.57605577
28TTN1.54789124
29NUAK11.53879042
30MTOR1.46383210
31WEE11.46128423
32GRK61.44356126
33ERN11.41334905
34CDK41.40057082
35PNCK1.38086379
36IKBKB1.33722116
37RIPK11.33137786
38MKNK11.32352245
39BMX1.32018726
40CDK61.30015206
41PDGFRA1.27459794
42RPS6KB21.26258281
43PLK41.22708575
44EIF2AK11.22009841
45MAP4K21.21674764
46AKT31.20875501
47TRIM281.18458132
48DMPK1.15360608
49PRPF4B1.11503959
50SIK31.07863471
51CDK71.02668619
52STK41.01082666
53IRAK20.99907527
54TAOK10.99748694
55STK30.99580523
56JAK30.97816075
57FGFR30.97328261
58LRRK20.95200278
59ATR0.92115777
60PAK40.89760600
61CHEK10.88918594
62NLK0.88707128
63PIM10.88144354
64BRSK10.87713583
65CDK90.87194534
66CLK10.86341413
67CHUK0.85595526
68PDGFRB0.85467616
69GSK3A0.85424625
70MAP3K70.85343078
71TYRO30.84942991
72IRAK30.83424954
73CSF1R0.82466523
74PRKCI0.81757047
75FGFR40.81353074
76HCK0.80868739
77TNIK0.80771693
78MAP3K80.79437385
79PAK20.79398348
80BMPR20.79356228
81MUSK0.78916837
82HIPK20.78023275
83CSK0.78006773
84BTK0.77721802
85TTK0.76103220
86PLK30.75126366
87ITK0.74497528
88BRSK20.72887856
89CDK20.71740945
90FER0.71197462
91RPS6KB10.70929988
92TGFBR20.69903930
93TYK20.69824677
94EPHB10.68896019
95ATM0.67598675
96STK240.67185270
97MST40.66768739
98GRK10.66506797
99MARK20.65408568
100JAK10.64516841
101PRKD20.63789281
102CHEK20.63696756
103ZAP700.63484588
104PASK0.62845568
105CSNK1G10.61528383
106CSNK1A10.60893445
107MAPK110.60876322
108FGFR20.58664013
109AKT20.57659664
110VRK10.56998673
111LMTK20.56885755
112RPS6KA40.56807253
113PRKCH0.56607038
114IRAK40.55823381
115SCYL20.55800693
116PLK20.55123619
117SGK30.54548953
118LATS20.54299232
119FES0.54287689
120MAPK140.54086067
121INSRR0.53892363
122EIF2AK20.51813237
123RPS6KL10.51314625
124RPS6KC10.51314625
125PLK10.50450463
126CDC42BPA0.50368265
127AURKB0.49987715
128CDK10.48505258
129RPS6KA10.47961966
130DYRK1B0.47518852
131MELK0.46893284
132RPS6KA60.46769594
133PRKD30.46703653
134SYK0.46279022
135MAPK10.45756973
136MAP3K110.45667414
137ZAK0.45665834
138FGFR10.45390183
139MAP3K140.45059221
140TNK20.44702027
141CSNK1D0.44165376
142RPS6KA20.42355852
143DDR20.42135387
144AKT10.41744941
145JAK20.41696752
146GSK3B0.41337382
147LCK0.41001855
148IRAK10.40026077
149CAMK2D0.39090457
150PRKDC0.38843442
151MAPK80.38168794
152TAOK30.37853037
153CAMK40.37590626
154AURKA0.37495469

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.98861333
2Chronic myeloid leukemia_Homo sapiens_hsa052202.15682540
3Lysine degradation_Homo sapiens_hsa003102.08698115
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.02850627
5Proteasome_Homo sapiens_hsa030501.87770437
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87281598
7Notch signaling pathway_Homo sapiens_hsa043301.85135224
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.79119575
9B cell receptor signaling pathway_Homo sapiens_hsa046621.79075926
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77912975
11Basal transcription factors_Homo sapiens_hsa030221.75350612
12Primary immunodeficiency_Homo sapiens_hsa053401.75350018
13Selenocompound metabolism_Homo sapiens_hsa004501.69092922
14mTOR signaling pathway_Homo sapiens_hsa041501.62748816
15Non-small cell lung cancer_Homo sapiens_hsa052231.60800622
16MicroRNAs in cancer_Homo sapiens_hsa052061.60561732
17mRNA surveillance pathway_Homo sapiens_hsa030151.58493146
18Acute myeloid leukemia_Homo sapiens_hsa052211.58172236
19Nucleotide excision repair_Homo sapiens_hsa034201.55403868
20Small cell lung cancer_Homo sapiens_hsa052221.52469816
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50647035
22Colorectal cancer_Homo sapiens_hsa052101.46174163
23Type I diabetes mellitus_Homo sapiens_hsa049401.46172306
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45907454
25Viral myocarditis_Homo sapiens_hsa054161.45498863
26Cell cycle_Homo sapiens_hsa041101.45000105
27Pancreatic cancer_Homo sapiens_hsa052121.42116357
28Endometrial cancer_Homo sapiens_hsa052131.41603732
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38133717
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37892811
31Adherens junction_Homo sapiens_hsa045201.37469634
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34663974
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31357739
34RNA polymerase_Homo sapiens_hsa030201.30560554
35DNA replication_Homo sapiens_hsa030301.30237352
36Spliceosome_Homo sapiens_hsa030401.29986223
37HTLV-I infection_Homo sapiens_hsa051661.29022589
38T cell receptor signaling pathway_Homo sapiens_hsa046601.25081713
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22165285
40Viral carcinogenesis_Homo sapiens_hsa052031.19948182
41Proteoglycans in cancer_Homo sapiens_hsa052051.17764838
42Base excision repair_Homo sapiens_hsa034101.17714069
43Osteoclast differentiation_Homo sapiens_hsa043801.16873660
44Basal cell carcinoma_Homo sapiens_hsa052171.16741993
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.16034207
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15336618
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.15010221
48Hepatitis B_Homo sapiens_hsa051611.14289439
49RNA transport_Homo sapiens_hsa030131.14107115
50Herpes simplex infection_Homo sapiens_hsa051681.13272441
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12304888
52Allograft rejection_Homo sapiens_hsa053301.11756978
53Graft-versus-host disease_Homo sapiens_hsa053321.11336082
54Measles_Homo sapiens_hsa051621.09295699
55N-Glycan biosynthesis_Homo sapiens_hsa005101.08947318
56Toxoplasmosis_Homo sapiens_hsa051451.08395999
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07637327
58Pyrimidine metabolism_Homo sapiens_hsa002401.07542973
59Glioma_Homo sapiens_hsa052141.07453411
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06423976
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03188859
62Prostate cancer_Homo sapiens_hsa052151.02376635
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.01456564
64One carbon pool by folate_Homo sapiens_hsa006701.01309974
65Antigen processing and presentation_Homo sapiens_hsa046120.99792190
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.99686304
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99640214
68Insulin resistance_Homo sapiens_hsa049310.98872163
69Apoptosis_Homo sapiens_hsa042100.98507126
70Autoimmune thyroid disease_Homo sapiens_hsa053200.96830650
71Renal cell carcinoma_Homo sapiens_hsa052110.96728949
72Platelet activation_Homo sapiens_hsa046110.96401913
73Focal adhesion_Homo sapiens_hsa045100.95923315
74Leishmaniasis_Homo sapiens_hsa051400.95859357
75VEGF signaling pathway_Homo sapiens_hsa043700.95175689
76Mismatch repair_Homo sapiens_hsa034300.93665303
77Dorso-ventral axis formation_Homo sapiens_hsa043200.92891039
78p53 signaling pathway_Homo sapiens_hsa041150.92481789
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91788185
80Hippo signaling pathway_Homo sapiens_hsa043900.87359137
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86737894
82Type II diabetes mellitus_Homo sapiens_hsa049300.86404171
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.86304164
84Chemokine signaling pathway_Homo sapiens_hsa040620.86177127
85Pathways in cancer_Homo sapiens_hsa052000.86161996
86Steroid biosynthesis_Homo sapiens_hsa001000.86042306
87Prolactin signaling pathway_Homo sapiens_hsa049170.84440676
88FoxO signaling pathway_Homo sapiens_hsa040680.83198797
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83147837
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83139300
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82371722
92Thyroid cancer_Homo sapiens_hsa052160.79888573
93Bladder cancer_Homo sapiens_hsa052190.78932645
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77750322
95HIF-1 signaling pathway_Homo sapiens_hsa040660.77479321
96Oocyte meiosis_Homo sapiens_hsa041140.76973936
97Protein export_Homo sapiens_hsa030600.76610794
98Influenza A_Homo sapiens_hsa051640.75500494
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74753884
100Hematopoietic cell lineage_Homo sapiens_hsa046400.73303970
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.72761599
102Vitamin B6 metabolism_Homo sapiens_hsa007500.71812886
103Insulin signaling pathway_Homo sapiens_hsa049100.71682406
104AMPK signaling pathway_Homo sapiens_hsa041520.71225450
105Legionellosis_Homo sapiens_hsa051340.70835828
106ErbB signaling pathway_Homo sapiens_hsa040120.69612711
107TNF signaling pathway_Homo sapiens_hsa046680.69165981
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68837650
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68622900
110Wnt signaling pathway_Homo sapiens_hsa043100.68416692
111Epstein-Barr virus infection_Homo sapiens_hsa051690.67830689
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67549234
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67145917
114Shigellosis_Homo sapiens_hsa051310.66440161
115Estrogen signaling pathway_Homo sapiens_hsa049150.65904150
116RNA degradation_Homo sapiens_hsa030180.63386746
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63247907
118Fanconi anemia pathway_Homo sapiens_hsa034600.63027949
119Non-homologous end-joining_Homo sapiens_hsa034500.62857083
120MAPK signaling pathway_Homo sapiens_hsa040100.62428901
121Hedgehog signaling pathway_Homo sapiens_hsa043400.61649951
122Purine metabolism_Homo sapiens_hsa002300.61416726
123Ether lipid metabolism_Homo sapiens_hsa005650.61032302
124Choline metabolism in cancer_Homo sapiens_hsa052310.61026743
125Rap1 signaling pathway_Homo sapiens_hsa040150.60836438
126TGF-beta signaling pathway_Homo sapiens_hsa043500.59642422
127Systemic lupus erythematosus_Homo sapiens_hsa053220.59060895
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58266393
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.56799703
130Amoebiasis_Homo sapiens_hsa051460.56050218
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54159633
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54096299
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49711170
134Hepatitis C_Homo sapiens_hsa051600.49207864
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49017660
136Asthma_Homo sapiens_hsa053100.45483881
137Sphingolipid metabolism_Homo sapiens_hsa006000.44398484
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43801926
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40806954
140Phototransduction_Homo sapiens_hsa047440.39802260

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