ZC3H6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)8.20709243
2piRNA metabolic process (GO:0034587)6.36523411
3female gamete generation (GO:0007292)5.41122638
4regulation of acrosome reaction (GO:0060046)5.21674607
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84768118
6multicellular organism reproduction (GO:0032504)4.77110100
7DNA methylation involved in gamete generation (GO:0043046)4.65720437
8regulation of meiosis (GO:0040020)4.56068203
9meiotic cell cycle (GO:0051321)4.37597145
10male meiosis (GO:0007140)4.32535789
11establishment of protein localization to Golgi (GO:0072600)4.23130502
12negative regulation of hormone biosynthetic process (GO:0032353)4.15848232
13negative regulation of hormone metabolic process (GO:0032351)4.15848232
14regulation of meiosis I (GO:0060631)4.04410030
15cilium or flagellum-dependent cell motility (GO:0001539)4.01708760
16negative regulation of meiosis (GO:0045835)3.99622700
17protein targeting to Golgi (GO:0000042)3.89814363
18regulation of meiotic cell cycle (GO:0051445)3.84485486
19cilium movement (GO:0003341)3.79022153
20oogenesis (GO:0048477)3.78807782
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78327068
22behavioral response to nicotine (GO:0035095)3.74054407
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73505885
24regulation of hypersensitivity (GO:0002883)3.69314610
25glycerophospholipid catabolic process (GO:0046475)3.65931698
26negative regulation of meiotic cell cycle (GO:0051447)3.65923880
27neuron cell-cell adhesion (GO:0007158)3.54769849
28reproduction (GO:0000003)3.43223496
29oocyte maturation (GO:0001556)3.34729732
30positive regulation of Cdc42 GTPase activity (GO:0043089)3.34406304
31regulation of calcium ion-dependent exocytosis (GO:0017158)3.30153182
32regulation of cAMP-dependent protein kinase activity (GO:2000479)3.27818130
33DNA damage induced protein phosphorylation (GO:0006975)3.26723396
34microtubule severing (GO:0051013)3.25884888
35interkinetic nuclear migration (GO:0022027)3.24247633
36epithelial cilium movement (GO:0003351)3.24053058
37regulation of phospholipid biosynthetic process (GO:0071071)3.22837455
38righting reflex (GO:0060013)3.17306946
39protein localization to Golgi apparatus (GO:0034067)3.13298754
40vocalization behavior (GO:0071625)3.09135270
41membrane depolarization during action potential (GO:0086010)3.03828955
42neuronal action potential (GO:0019228)2.99763422
43negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.98689830
44negative regulation of reproductive process (GO:2000242)2.95901105
45single fertilization (GO:0007338)2.95845839
46synaptic transmission, glutamatergic (GO:0035249)2.95264012
47regulation of DNA methylation (GO:0044030)2.93315697
48positive regulation of meiosis (GO:0045836)2.92494275
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92011457
50fertilization (GO:0009566)2.91382578
51neural tube formation (GO:0001841)2.91181167
52positive regulation of humoral immune response (GO:0002922)2.89798637
53parturition (GO:0007567)2.89017869
54negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88244533
55DNA alkylation (GO:0006305)2.87960488
56DNA methylation (GO:0006306)2.87960488
57regulation of cilium movement (GO:0003352)2.87892106
58protein localization to cilium (GO:0061512)2.83912211
59regulation of RIG-I signaling pathway (GO:0039535)2.81314494
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81294457
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80726960
62positive regulation of meiotic cell cycle (GO:0051446)2.79875551
63positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.77667974
64oocyte development (GO:0048599)2.77616156
65protein kinase C signaling (GO:0070528)2.77513590
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77470492
67protein K11-linked deubiquitination (GO:0035871)2.76082093
68startle response (GO:0001964)2.75425527
69centriole replication (GO:0007099)2.73759961
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72027971
71presynaptic membrane assembly (GO:0097105)2.71770133
72synaptic vesicle exocytosis (GO:0016079)2.71484520
73eye photoreceptor cell differentiation (GO:0001754)2.71091875
74photoreceptor cell differentiation (GO:0046530)2.71091875
75axonemal dynein complex assembly (GO:0070286)2.70316841
76cAMP catabolic process (GO:0006198)2.69859701
77regulation of short-term neuronal synaptic plasticity (GO:0048172)2.69391700
78neuron-neuron synaptic transmission (GO:0007270)2.69159873
79mitotic metaphase plate congression (GO:0007080)2.69127756
80synaptic vesicle endocytosis (GO:0048488)2.69045041
81regulation of histone H3-K27 methylation (GO:0061085)2.68911515
82transmission of nerve impulse (GO:0019226)2.68836788
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.68683065
84intraciliary transport (GO:0042073)2.67942312
85attachment of spindle microtubules to kinetochore (GO:0008608)2.67511718
86microtubule nucleation (GO:0007020)2.66952552
87histone H2A monoubiquitination (GO:0035518)2.65935853
88regulation of synaptic vesicle transport (GO:1902803)2.65605455
89establishment of spindle localization (GO:0051293)2.65489056
90cerebellar Purkinje cell differentiation (GO:0021702)2.63741628
91pyrimidine nucleobase catabolic process (GO:0006208)2.63193340
92cyclic nucleotide catabolic process (GO:0009214)2.62218319
93protein polyglutamylation (GO:0018095)2.62076696
94gamma-aminobutyric acid transport (GO:0015812)2.61757224
95detection of light stimulus involved in visual perception (GO:0050908)2.61560337
96detection of light stimulus involved in sensory perception (GO:0050962)2.61560337
97brain morphogenesis (GO:0048854)2.60445906
98cellular ketone body metabolic process (GO:0046950)2.60075280
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58930345
100behavioral response to ethanol (GO:0048149)2.57494717
101sperm motility (GO:0030317)2.56741568
102regulation of synaptic vesicle exocytosis (GO:2000300)2.56494953
103regulation of transforming growth factor beta2 production (GO:0032909)2.56469059
104L-fucose catabolic process (GO:0042355)2.56307807
105fucose catabolic process (GO:0019317)2.56307807
106L-fucose metabolic process (GO:0042354)2.56307807
107protein localization to synapse (GO:0035418)2.56193104
108regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.55691430
109mitotic chromosome condensation (GO:0007076)2.55609151
110histone H3-K4 trimethylation (GO:0080182)2.54527662
111regulation of steroid hormone secretion (GO:2000831)2.54170029
112cilium assembly (GO:0042384)2.53612852
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53394736
114cilium morphogenesis (GO:0060271)2.53294820
115synaptic vesicle maturation (GO:0016188)2.52632031
116synaptic vesicle docking involved in exocytosis (GO:0016081)2.52396068
117activated T cell proliferation (GO:0050798)2.51864832
118axoneme assembly (GO:0035082)2.51228310
119glutamate receptor signaling pathway (GO:0007215)2.50879948
120ovulation cycle (GO:0042698)2.50724053
121regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.49064471
122regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.49064471
123type B pancreatic cell development (GO:0003323)2.49005575
124cilium organization (GO:0044782)2.47935036
125negative regulation of neurotransmitter transport (GO:0051589)2.47205621
126regulation of cell maturation (GO:1903429)2.47136396
127neuronal action potential propagation (GO:0019227)2.47122131
128regulation of ARF protein signal transduction (GO:0032012)2.46777142
129photoreceptor cell maintenance (GO:0045494)2.46573939
130locomotory exploration behavior (GO:0035641)2.46539806
131positive regulation of megakaryocyte differentiation (GO:0045654)2.45940441
132regulation of glucocorticoid metabolic process (GO:0031943)2.45867302
133motile cilium assembly (GO:0044458)2.45551218
134apical protein localization (GO:0045176)2.45408211
135cerebral cortex radially oriented cell migration (GO:0021799)2.45235200
136regulation of protein glycosylation (GO:0060049)2.43638781
137primary amino compound metabolic process (GO:1901160)2.42413822
138regulation of action potential (GO:0098900)2.39870165
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39610964
140nucleobase catabolic process (GO:0046113)2.36373060
141action potential (GO:0001508)2.36336445
142calcium ion import (GO:0070509)2.34619213
143somite development (GO:0061053)2.34447802
144dopamine transport (GO:0015872)2.34207152
145regulation of microtubule-based movement (GO:0060632)2.33048281
146regulation of membrane repolarization (GO:0060306)2.32275883
147dentate gyrus development (GO:0021542)2.31941465
148cellular component assembly involved in morphogenesis (GO:0010927)2.31504779
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.31298877
150regulation of translation, ncRNA-mediated (GO:0045974)2.31298877
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31298877
152calcium ion-dependent exocytosis (GO:0017156)2.31219420
153serotonin metabolic process (GO:0042428)2.30909499
154ionotropic glutamate receptor signaling pathway (GO:0035235)2.30875496
155response to pheromone (GO:0019236)2.29729276
156adaptation of signaling pathway (GO:0023058)2.29726823
157presynaptic membrane organization (GO:0097090)2.28656033
158ketone body metabolic process (GO:1902224)2.28388274
159nonmotile primary cilium assembly (GO:0035058)2.27552634
160nephron epithelium morphogenesis (GO:0072088)2.25377121
161nephron tubule morphogenesis (GO:0072078)2.25377121
162regulation of neurotransmitter uptake (GO:0051580)2.25043895
163axon ensheathment in central nervous system (GO:0032291)2.23551012
164central nervous system myelination (GO:0022010)2.23551012
165neuromuscular synaptic transmission (GO:0007274)2.23417229
166phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.22825728
167indolalkylamine metabolic process (GO:0006586)2.22344635
168insulin secretion (GO:0030073)2.22260476
169urinary tract smooth muscle contraction (GO:0014848)2.21878842
170adult walking behavior (GO:0007628)2.21451493
171nucleus localization (GO:0051647)2.21129925
172behavioral defense response (GO:0002209)2.17100400
173behavioral fear response (GO:0001662)2.17100400
174postsynaptic membrane organization (GO:0001941)2.16887245
175intra-Golgi vesicle-mediated transport (GO:0006891)2.16502166
176reflex (GO:0060004)2.16412033
177negative regulation of cAMP-mediated signaling (GO:0043951)2.16009126
178renal tubule morphogenesis (GO:0061333)2.15537012
179negative regulation of appetite (GO:0032099)2.14695092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09538277
2GBX2_23144817_ChIP-Seq_PC3_Human3.47424981
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83741781
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.82349701
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50648238
6SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.31626283
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31039589
8ZNF274_21170338_ChIP-Seq_K562_Hela2.25389370
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23542759
10TAF15_26573619_Chip-Seq_HEK293_Human2.07188210
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07143235
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.05771133
13SMAD4_21799915_ChIP-Seq_A2780_Human1.97188187
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90527334
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90434198
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88035548
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.86163182
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86006541
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85507566
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84722047
21STAT3_23295773_ChIP-Seq_U87_Human1.80211975
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76223787
23ER_23166858_ChIP-Seq_MCF-7_Human1.75376925
24RNF2_27304074_Chip-Seq_NSC_Mouse1.73332505
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73027402
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72990184
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72847125
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66397423
29* NANOG_18555785_Chip-Seq_ESCs_Mouse1.62534373
30P300_19829295_ChIP-Seq_ESCs_Human1.59450533
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57361504
32AR_21572438_ChIP-Seq_LNCaP_Human1.56874901
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56550094
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55849490
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.55187580
36FUS_26573619_Chip-Seq_HEK293_Human1.53494590
37TCF4_23295773_ChIP-Seq_U87_Human1.51893833
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49007126
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.48896437
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48231440
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48072155
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48072155
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47387802
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46801677
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46349095
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46282401
47CBP_20019798_ChIP-Seq_JUKART_Human1.46282401
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45210334
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45053008
50AR_25329375_ChIP-Seq_VCAP_Human1.42999015
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42816888
52IGF1R_20145208_ChIP-Seq_DFB_Human1.42405465
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38767501
54REST_21632747_ChIP-Seq_MESCs_Mouse1.38554059
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37448221
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36655782
57KDM2B_26808549_Chip-Seq_REH_Human1.34552348
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33611739
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33266146
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32712110
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32168959
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31736193
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.31482192
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30484064
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29823887
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27302994
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26937565
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.26865152
69* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26017847
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25396051
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25396051
72* STAT3_18555785_Chip-Seq_ESCs_Mouse1.24834123
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.24623405
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24482588
75* P53_22387025_ChIP-Seq_ESCs_Mouse1.23530072
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.23065869
77* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22714124
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.21879952
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.21535174
80* SOX2_18555785_Chip-Seq_ESCs_Mouse1.21434725
81VDR_22108803_ChIP-Seq_LS180_Human1.20754403
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.20754068
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.19279991
84* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18983897
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.18627763
86* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18169047
87DROSHA_22980978_ChIP-Seq_HELA_Human1.18127695
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17876838
89* NMYC_18555785_Chip-Seq_ESCs_Mouse1.16562119
90TCF4_22108803_ChIP-Seq_LS180_Human1.16360790
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15952149
92TP53_16413492_ChIP-PET_HCT116_Human1.15777310
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.15067869
94BCAT_22108803_ChIP-Seq_LS180_Human1.14735120
95* CTCF_18555785_Chip-Seq_ESCs_Mouse1.13961754
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13398678
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13242804
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12996766
99STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12922093
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.12762806
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12599313
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12140092
103EWS_26573619_Chip-Seq_HEK293_Human1.11742636
104* KLF4_18555785_Chip-Seq_ESCs_Mouse1.10090984
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08693881
106AHR_22903824_ChIP-Seq_MCF-7_Human1.08646157
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08386885
108* OCT4_18555785_Chip-Seq_ESCs_Mouse1.08109548
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07975248
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07691272
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07683286
112RUNX2_22187159_ChIP-Seq_PCA_Human1.07535636
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07481216
114* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07234211
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06973341
116* P300_18555785_Chip-Seq_ESCs_Mouse1.06686327
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.05295605
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04450698
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03883799
120SOX2_19829295_ChIP-Seq_ESCs_Human1.03749887
121NANOG_19829295_ChIP-Seq_ESCs_Human1.03749887
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03599212
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.02517857
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02383099
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01864121
126CDX2_22108803_ChIP-Seq_LS180_Human1.01778325
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98985300
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97720862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.15633522
2MP0003646_muscle_fatigue3.74641572
3MP0008877_abnormal_DNA_methylation3.50990458
4MP0003718_maternal_effect3.42327132
5MP0003787_abnormal_imprinting3.30504037
6MP0002102_abnormal_ear_morphology2.88828679
7MP0005646_abnormal_pituitary_gland2.81650001
8MP0004270_analgesia2.79588954
9MP0003880_abnormal_central_pattern2.71404250
10MP0005451_abnormal_body_composition2.54780543
11MP0003635_abnormal_synaptic_transmissio2.40676743
12MP0001929_abnormal_gametogenesis2.08769505
13MP0006292_abnormal_olfactory_placode2.06639653
14MP0006072_abnormal_retinal_apoptosis2.05838281
15MP0001905_abnormal_dopamine_level2.00905899
16MP0003699_abnormal_female_reproductive2.00052418
17MP0002063_abnormal_learning/memory/cond1.97752296
18MP0002734_abnormal_mechanical_nocicepti1.96623758
19MP0009745_abnormal_behavioral_response1.96254176
20MP0001119_abnormal_female_reproductive1.96124951
21MP0004142_abnormal_muscle_tone1.95988678
22MP0003195_calcinosis1.86006202
23MP0002572_abnormal_emotion/affect_behav1.80791417
24MP0001501_abnormal_sleep_pattern1.80306298
25MP0010386_abnormal_urinary_bladder1.78191010
26MP0004130_abnormal_muscle_cell1.77265886
27MP0000569_abnormal_digit_pigmentation1.76884361
28MP0004510_myositis1.73676273
29MP0005310_abnormal_salivary_gland1.73463771
30MP0004043_abnormal_pH_regulation1.69545073
31MP0002653_abnormal_ependyma_morphology1.68666622
32MP0002638_abnormal_pupillary_reflex1.68650583
33MP0003122_maternal_imprinting1.67881446
34MP0002249_abnormal_larynx_morphology1.67091882
35MP0005395_other_phenotype1.60950054
36MP0000653_abnormal_sex_gland1.60608966
37MP0004145_abnormal_muscle_electrophysio1.59922949
38MP0003136_yellow_coat_color1.58012655
39MP0002837_dystrophic_cardiac_calcinosis1.55508541
40MP0002272_abnormal_nervous_system1.55290490
41MP0009046_muscle_twitch1.53796736
42MP0003329_amyloid_beta_deposits1.53473153
43MP0005174_abnormal_tail_pigmentation1.52202282
44MP0003879_abnormal_hair_cell1.52105019
45MP0001968_abnormal_touch/_nociception1.51834007
46MP0003121_genomic_imprinting1.48808749
47MP0001984_abnormal_olfaction1.48169996
48MP0001986_abnormal_taste_sensitivity1.46603307
49MP0002909_abnormal_adrenal_gland1.45370485
50MP0002210_abnormal_sex_determination1.44816140
51MP0002876_abnormal_thyroid_physiology1.42356718
52MP0002736_abnormal_nociception_after1.42089796
53MP0002161_abnormal_fertility/fecundity1.41272306
54MP0002064_seizures1.37762856
55MP0001485_abnormal_pinna_reflex1.36411712
56MP0000631_abnormal_neuroendocrine_gland1.36360253
57MP0002557_abnormal_social/conspecific_i1.32218573
58MP0001502_abnormal_circadian_rhythm1.32128443
59MP0001486_abnormal_startle_reflex1.30508772
60MP0001919_abnormal_reproductive_system1.29305765
61MP0004215_abnormal_myocardial_fiber1.28697596
62MP0005389_reproductive_system_phenotype1.28616006
63MP0001188_hyperpigmentation1.28256899
64MP0003183_abnormal_peptide_metabolism1.27509253
65MP0005408_hypopigmentation1.27340908
66MP0003698_abnormal_male_reproductive1.26806906
67MP0005386_behavior/neurological_phenoty1.26789259
68MP0004924_abnormal_behavior1.26789259
69MP0001529_abnormal_vocalization1.26462097
70MP0002822_catalepsy1.25090631
71MP0006276_abnormal_autonomic_nervous1.25044409
72MP0002067_abnormal_sensory_capabilities1.23159156
73MP0005645_abnormal_hypothalamus_physiol1.20931500
74MP0004147_increased_porphyrin_level1.19063132
75MP0000427_abnormal_hair_cycle1.17650892
76MP0000230_abnormal_systemic_arterial1.12536885
77MP0003633_abnormal_nervous_system1.12495813
78MP0008872_abnormal_physiological_respon1.10444734
79MP0002928_abnormal_bile_duct1.10193140
80MP0001963_abnormal_hearing_physiology1.09993990
81MP0008569_lethality_at_weaning1.09311688
82MP0001970_abnormal_pain_threshold1.08452502
83MP0004084_abnormal_cardiac_muscle1.07829038
84MP0005377_hearing/vestibular/ear_phenot1.07768709
85MP0003878_abnormal_ear_physiology1.07768709
86MP0002735_abnormal_chemical_nociception1.06470062
87MP0000955_abnormal_spinal_cord1.05171383
88MP0002160_abnormal_reproductive_system1.03801198
89MP0005647_abnormal_sex_gland1.03611331
90MP0002733_abnormal_thermal_nociception1.03280955
91MP0001440_abnormal_grooming_behavior1.02596631
92MP0000678_abnormal_parathyroid_gland1.02254643
93MP0005423_abnormal_somatic_nervous1.01487700
94MP0002184_abnormal_innervation1.00538940
95MP0004885_abnormal_endolymph0.98961859
96MP0003011_delayed_dark_adaptation0.98387016
97MP0000778_abnormal_nervous_system0.97202804
98MP0002295_abnormal_pulmonary_circulatio0.95823073
99MP0004036_abnormal_muscle_relaxation0.94918439
100MP0000015_abnormal_ear_pigmentation0.94049252
101MP0008775_abnormal_heart_ventricle0.93276473
102MP0005551_abnormal_eye_electrophysiolog0.92882546
103MP0004085_abnormal_heartbeat0.91194075
104MP0003631_nervous_system_phenotype0.89319963
105MP0002177_abnormal_outer_ear0.89030335
106MP0000579_abnormal_nail_morphology0.88652367
107MP0005410_abnormal_fertilization0.87280782
108MP0001145_abnormal_male_reproductive0.86023250
109MP0010234_abnormal_vibrissa_follicle0.85334240
110MP0002882_abnormal_neuron_morphology0.84315123
111MP0010094_abnormal_chromosome_stability0.84153981
112MP0002234_abnormal_pharynx_morphology0.83480237
113MP0003045_fibrosis0.82855940
114MP0004381_abnormal_hair_follicle0.82416036
115MP0003950_abnormal_plasma_membrane0.81082762
116MP0001765_abnormal_ion_homeostasis0.79338698
117MP0004484_altered_response_of0.79017724
118MP0000639_abnormal_adrenal_gland0.77368862
119MP0003763_abnormal_thymus_physiology0.77195757
120MP0003937_abnormal_limbs/digits/tail_de0.77030206
121MP0002066_abnormal_motor_capabilities/c0.76503774
122MP0005620_abnormal_muscle_contractility0.76299330
123MP0000026_abnormal_inner_ear0.76098096
124MP0002693_abnormal_pancreas_physiology0.75843384
125MP0009780_abnormal_chondrocyte_physiolo0.75517183
126MP0002095_abnormal_skin_pigmentation0.75371070
127MP0005167_abnormal_blood-brain_barrier0.73898666
128MP0005448_abnormal_energy_balance0.73762828
129MP0005195_abnormal_posterior_eye0.73147917
130MP0005253_abnormal_eye_physiology0.73135169
131MP0008995_early_reproductive_senescence0.72364784
132MP0004742_abnormal_vestibular_system0.72360740
133MP0002229_neurodegeneration0.72339461
134MP0002752_abnormal_somatic_nervous0.70067643
135MP0002877_abnormal_melanocyte_morpholog0.69153119

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.23226580
2Male infertility (HP:0003251)4.79730711
3Abnormal respiratory motile cilium physiology (HP:0012261)4.54715723
4Pancreatic fibrosis (HP:0100732)4.11792190
5Infertility (HP:0000789)3.93635684
6Abnormal ciliary motility (HP:0012262)3.85742921
7Papillary thyroid carcinoma (HP:0002895)3.75925783
8Lip pit (HP:0100267)3.71256114
9Focal motor seizures (HP:0011153)3.70712988
10True hermaphroditism (HP:0010459)3.59362817
11Genetic anticipation (HP:0003743)3.55410257
12Abnormality of midbrain morphology (HP:0002418)3.51826068
13Molar tooth sign on MRI (HP:0002419)3.51826068
14Rhinitis (HP:0012384)3.44682359
15Atonic seizures (HP:0010819)3.35966233
16Pancreatic cysts (HP:0001737)3.23503432
17Febrile seizures (HP:0002373)3.22029775
18Chronic bronchitis (HP:0004469)3.19182915
19Gait imbalance (HP:0002141)3.19018523
20Abnormality of the renal medulla (HP:0100957)3.18898382
21Nephronophthisis (HP:0000090)3.18667771
22Polydipsia (HP:0001959)3.10722841
23Abnormal drinking behavior (HP:0030082)3.10722841
24Congenital stationary night blindness (HP:0007642)3.07893274
25Medial flaring of the eyebrow (HP:0010747)3.07872901
26Dynein arm defect of respiratory motile cilia (HP:0012255)3.06980971
27Absent/shortened dynein arms (HP:0200106)3.06980971
28Congenital primary aphakia (HP:0007707)3.06933737
29Protruding tongue (HP:0010808)2.96820343
30Tubular atrophy (HP:0000092)2.94981760
31Epileptic encephalopathy (HP:0200134)2.91259471
32Nephrogenic diabetes insipidus (HP:0009806)2.84782711
33Cystic liver disease (HP:0006706)2.81661712
34Flat capital femoral epiphysis (HP:0003370)2.79444836
35Occipital encephalocele (HP:0002085)2.78735150
36Poor coordination (HP:0002370)2.70785336
37Fetal akinesia sequence (HP:0001989)2.66732654
38Focal seizures (HP:0007359)2.61578399
39Arterial tortuosity (HP:0005116)2.56375049
40Abnormality of the fingertips (HP:0001211)2.55914016
41Absent speech (HP:0001344)2.51909392
42Abnormality of cochlea (HP:0000375)2.48802289
43Type 2 muscle fiber atrophy (HP:0003554)2.46903441
44Decreased circulating renin level (HP:0003351)2.44726804
45Abnormality of chromosome segregation (HP:0002916)2.44617857
46Genital tract atresia (HP:0001827)2.41531708
47Attenuation of retinal blood vessels (HP:0007843)2.41243580
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.40287971
49Renal cortical cysts (HP:0000803)2.39629395
50Abnormality of the labia minora (HP:0012880)2.31900666
51Muscle fiber atrophy (HP:0100295)2.28828208
52Bronchiectasis (HP:0002110)2.28174358
53Widely spaced teeth (HP:0000687)2.27116968
54Type II lissencephaly (HP:0007260)2.25045395
55Abnormality of the fovea (HP:0000493)2.20770109
56Vaginal atresia (HP:0000148)2.20643422
57Polyuria (HP:0000103)2.19044602
58Chronic sinusitis (HP:0011109)2.18807864
59Hyperventilation (HP:0002883)2.18629204
60Drooling (HP:0002307)2.17975491
61Excessive salivation (HP:0003781)2.17975491
62Decreased central vision (HP:0007663)2.17187587
63Fair hair (HP:0002286)2.15076185
64Generalized tonic-clonic seizures (HP:0002069)2.14674173
65Acute myeloid leukemia (HP:0004808)2.14306284
66Clumsiness (HP:0002312)2.13257859
67Agitation (HP:0000713)2.12872637
68Premature ovarian failure (HP:0008209)2.12769339
69Nonprogressive disorder (HP:0003680)2.12733616
70Pulmonary fibrosis (HP:0002206)2.10469978
71Broad-based gait (HP:0002136)2.09120360
72Hypoplastic ischia (HP:0003175)2.07047914
73Calf muscle hypertrophy (HP:0008981)2.07002013
74Aplasia/Hypoplasia of the lens (HP:0008063)2.06538870
75Tubulointerstitial nephritis (HP:0001970)2.06538791
76Thyroid carcinoma (HP:0002890)2.06422133
77Abnormal respiratory epithelium morphology (HP:0012253)2.04820660
78Abnormal respiratory motile cilium morphology (HP:0005938)2.04820660
79Abnormal rod and cone electroretinograms (HP:0008323)2.04211537
80Vascular tortuosity (HP:0004948)2.03957914
81Prolonged QT interval (HP:0001657)2.02933312
82Postaxial foot polydactyly (HP:0001830)2.02609078
83Oligodactyly (hands) (HP:0001180)2.01947885
84Abnormal hair whorl (HP:0010721)2.01731038
85Abnormality of the renal cortex (HP:0011035)2.01450678
86Hypoplasia of the fovea (HP:0007750)2.00783218
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.00783218
88Papilledema (HP:0001085)2.00532623
89Congenital hepatic fibrosis (HP:0002612)1.99253823
90Muscle hypertrophy of the lower extremities (HP:0008968)1.99072928
91Bony spicule pigmentary retinopathy (HP:0007737)1.98042490
92Abnormality of the ischium (HP:0003174)1.97622615
93Generalized hypopigmentation of hair (HP:0011358)1.97492997
94Supernumerary spleens (HP:0009799)1.96434929
95Thyroid-stimulating hormone excess (HP:0002925)1.96372144
96Hypothermia (HP:0002045)1.96212556
97Inability to walk (HP:0002540)1.95909487
98Tubulointerstitial abnormality (HP:0001969)1.95351313
99Postural instability (HP:0002172)1.94685912
100Volvulus (HP:0002580)1.94515768
101Abolished electroretinogram (ERG) (HP:0000550)1.94270241
102Bronchitis (HP:0012387)1.92507743
103Postaxial hand polydactyly (HP:0001162)1.92261096
104Truncal obesity (HP:0001956)1.92143822
105Morphological abnormality of the inner ear (HP:0011390)1.91753583
106Chromsome breakage (HP:0040012)1.91097111
107Hyperkalemia (HP:0002153)1.90195878
108Adrenal hypoplasia (HP:0000835)1.89736141
109Gaze-evoked nystagmus (HP:0000640)1.89624032
110Hemiparesis (HP:0001269)1.89040006
111Furrowed tongue (HP:0000221)1.88293150
112Narrow forehead (HP:0000341)1.85137732
113Chronic hepatic failure (HP:0100626)1.85072838
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.85055426
115Male pseudohermaphroditism (HP:0000037)1.84359859
116Insulin-resistant diabetes mellitus (HP:0000831)1.84137999
117Polyphagia (HP:0002591)1.84088117
118Absence seizures (HP:0002121)1.82815577
119Large for gestational age (HP:0001520)1.82288782
120Facial hemangioma (HP:0000329)1.82238434
121Spondylolisthesis (HP:0003302)1.81835689
122Abnormal biliary tract physiology (HP:0012439)1.80828729
123Bile duct proliferation (HP:0001408)1.80828729
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80627789
125Ventricular fibrillation (HP:0001663)1.79893053
126Hypomagnesemia (HP:0002917)1.79803820
127Syncope (HP:0001279)1.79798822
128Epileptiform EEG discharges (HP:0011182)1.79756004
129Atelectasis (HP:0100750)1.79235998
130Action tremor (HP:0002345)1.79037334
131Pachygyria (HP:0001302)1.78085374
132Progressive cerebellar ataxia (HP:0002073)1.77998913
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.76908665
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76908665
135Optic nerve hypoplasia (HP:0000609)1.76017589
136Cystic hygroma (HP:0000476)1.75650766
137Abnormality of salivation (HP:0100755)1.75487814
138Short tibia (HP:0005736)1.75413112
139Stomach cancer (HP:0012126)1.75308835
140Highly arched eyebrow (HP:0002553)1.75088423
141Cone-rod dystrophy (HP:0000548)1.74745004
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.74539698
143Thyroiditis (HP:0100646)1.73913449
144Dialeptic seizures (HP:0011146)1.73480394
145Broad foot (HP:0001769)1.72893686
146Congenital sensorineural hearing impairment (HP:0008527)1.72674348
147Lissencephaly (HP:0001339)1.71191597
148Urinary bladder sphincter dysfunction (HP:0002839)1.70315540
149Long face (HP:0000276)1.69363332
150Left ventricular hypertrophy (HP:0001712)1.68387036
151Abnormality of the epiphysis of the femoral head (HP:0010574)1.67121184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.68549795
2MAP3K63.54597363
3TAOK33.45567685
4BRAF3.23502056
5BMPR23.14858265
6MAP3K133.00867980
7PINK13.00519534
8CASK2.96396956
9MAP3K92.91962006
10EEF2K2.68642437
11TTK2.67021046
12MOS2.47955489
13KSR22.46941280
14OBSCN2.20081534
15MAP3K42.14330635
16PLK42.12560365
17WNK32.11010684
18MAP2K72.05363974
19MAPK131.90917926
20MAP4K21.84905893
21ADRBK21.82402821
22ACVR1B1.76690421
23STK38L1.74424587
24PRKD31.74223384
25RAF11.69748290
26ARAF1.69515776
27NTRK31.64401365
28WNK41.64119233
29ERBB41.63214069
30PAK61.61482955
31LATS11.61426285
32INSRR1.56410322
33EPHA41.50193123
34GRK11.41868250
35STK101.38937768
36NTRK21.36776294
37KSR11.34598153
38TXK1.30620707
39MELK1.24568019
40PHKG11.22957674
41PHKG21.22957674
42PLK21.22362963
43MAP2K41.19298841
44TEC1.19102119
45MAPKAPK51.17686990
46MAP3K121.17461185
47PIK3CA1.12597483
48LATS21.11939156
49PTK2B1.11620325
50STK391.11607367
51TNIK1.09184398
52CAMKK21.08450322
53MAPKAPK31.08369814
54PRKD21.06699933
55SGK21.06163779
56PIK3CG1.04196383
57CDK91.03550355
58WNK11.02787876
59TLK10.98451374
60FGFR20.96495658
61AKT30.93075252
62TAOK10.91976164
63MARK20.89059322
64ADRBK10.88492405
65CAMK10.87557544
66MAPK150.85437271
67PRKCG0.83927307
68STK380.83389411
69SGK2230.82810092
70SGK4940.82810092
71CAMK1G0.81979153
72CSNK1G20.79701974
73CAMK2A0.79146821
74PRKAA20.78978044
75STK240.76996108
76PRKCE0.76568170
77MARK30.75532479
78RET0.75294310
79CSNK1G10.75276679
80ZAK0.71663734
81NEK90.69504129
82RIPK40.68045112
83CSNK1A1L0.67893401
84CSNK1G30.67237049
85CHEK20.66957326
86MAP3K70.66419465
87SGK30.65235679
88ERBB20.62783494
89DYRK20.60905406
90TIE10.59298779
91CDC42BPA0.59291545
92CDK80.59000124
93PRKG10.58641321
94CAMK40.58375768
95ITK0.58182962
96NLK0.58146837
97SYK0.56485978
98PRPF4B0.56197308
99TRIM280.55868008
100PAK30.54204929
101TYRO30.53012989
102BMPR1B0.52800756
103MAPK120.52716945
104TGFBR10.51192581
105DMPK0.49706067
106UHMK10.49411909
107CDK30.49282741
108STK30.49075894
109BTK0.48347610
110PRKACA0.46553000
111STK110.45834269
112NTRK10.45712604
113HIPK20.44630538
114PRKCZ0.44108810
115SGK10.43599031
116PRKAA10.43380305
117PLK10.43229944
118EPHA30.43067156
119MINK10.43000301
120CAMK1D0.42610651
121NUAK10.42042817
122NEK20.41628833
123TRPM70.41489753
124PRKCQ0.41036096
125CAMKK10.40602089
126CSNK1D0.40261422
127RPS6KA50.39018365
128PRKCH0.38777017
129TNK20.38628474
130BRD40.38527385
131CDC70.37861985
132DAPK20.37365275
133BCR0.36692018
134CDK50.36394351
135OXSR10.35397949
136CDK190.35215796
137DYRK1A0.34112581
138FRK0.32880508
139FGR0.32071757
140MARK10.31602939
141PKN10.30110618
142ROCK20.27431507
143MAP3K80.27045025
144GRK50.26092749
145PNCK0.25596403
146MAPK100.24827937
147MKNK20.24212366
148PDK10.23372143
149FES0.22604808
150SIK20.22333707

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049132.75254533
2Nicotine addiction_Homo sapiens_hsa050332.73653495
3Olfactory transduction_Homo sapiens_hsa047402.49817733
4Circadian rhythm_Homo sapiens_hsa047102.28471654
5Glutamatergic synapse_Homo sapiens_hsa047242.16159588
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06413342
7Nitrogen metabolism_Homo sapiens_hsa009101.92977825
8Synaptic vesicle cycle_Homo sapiens_hsa047211.89031782
9Morphine addiction_Homo sapiens_hsa050321.88556722
10Circadian entrainment_Homo sapiens_hsa047131.88427754
11Serotonergic synapse_Homo sapiens_hsa047261.80282722
12Long-term potentiation_Homo sapiens_hsa047201.79052738
13Butanoate metabolism_Homo sapiens_hsa006501.78675453
14RNA degradation_Homo sapiens_hsa030181.78143220
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.77982233
16Amphetamine addiction_Homo sapiens_hsa050311.77395328
17Long-term depression_Homo sapiens_hsa047301.77040074
18Ether lipid metabolism_Homo sapiens_hsa005651.76248126
19GnRH signaling pathway_Homo sapiens_hsa049121.73370075
20GABAergic synapse_Homo sapiens_hsa047271.62227045
21Dorso-ventral axis formation_Homo sapiens_hsa043201.59607010
22Insulin secretion_Homo sapiens_hsa049111.58927458
23Oocyte meiosis_Homo sapiens_hsa041141.53995167
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50244617
25Taste transduction_Homo sapiens_hsa047421.48330057
26Dopaminergic synapse_Homo sapiens_hsa047281.47692128
27Salivary secretion_Homo sapiens_hsa049701.47365102
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42243586
29Cell cycle_Homo sapiens_hsa041101.38982367
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37031023
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35264908
32Choline metabolism in cancer_Homo sapiens_hsa052311.33678529
33Phototransduction_Homo sapiens_hsa047441.33074669
34Cholinergic synapse_Homo sapiens_hsa047251.32544770
35cAMP signaling pathway_Homo sapiens_hsa040241.32324148
36Linoleic acid metabolism_Homo sapiens_hsa005911.31991002
37Cocaine addiction_Homo sapiens_hsa050301.31881831
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30451676
39ABC transporters_Homo sapiens_hsa020101.29590204
40Basal transcription factors_Homo sapiens_hsa030221.28619657
41Oxytocin signaling pathway_Homo sapiens_hsa049211.26827934
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22737852
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22158181
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20136359
45Pancreatic cancer_Homo sapiens_hsa052121.18028429
46Gastric acid secretion_Homo sapiens_hsa049711.14863808
47Regulation of autophagy_Homo sapiens_hsa041401.13405855
48Renin secretion_Homo sapiens_hsa049241.11512216
49Prolactin signaling pathway_Homo sapiens_hsa049171.10531280
50Calcium signaling pathway_Homo sapiens_hsa040201.09830489
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.07582716
52Ras signaling pathway_Homo sapiens_hsa040141.07464863
53Cardiac muscle contraction_Homo sapiens_hsa042601.05336389
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04265436
55Collecting duct acid secretion_Homo sapiens_hsa049661.03700463
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03677888
57Inositol phosphate metabolism_Homo sapiens_hsa005621.02591601
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01673071
59Estrogen signaling pathway_Homo sapiens_hsa049150.98958825
60MAPK signaling pathway_Homo sapiens_hsa040100.94878191
61Fanconi anemia pathway_Homo sapiens_hsa034600.92897752
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90841797
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90043342
64ErbB signaling pathway_Homo sapiens_hsa040120.88988544
65Platelet activation_Homo sapiens_hsa046110.88358601
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87592394
67Vitamin B6 metabolism_Homo sapiens_hsa007500.86775343
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.86612900
69FoxO signaling pathway_Homo sapiens_hsa040680.84286219
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82593176
71Colorectal cancer_Homo sapiens_hsa052100.81387742
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80391411
73VEGF signaling pathway_Homo sapiens_hsa043700.77063831
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.77003366
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76498039
76Arachidonic acid metabolism_Homo sapiens_hsa005900.75849754
77Propanoate metabolism_Homo sapiens_hsa006400.75250015
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75133621
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74233571
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74040327
81Tryptophan metabolism_Homo sapiens_hsa003800.73873741
82Glycerolipid metabolism_Homo sapiens_hsa005610.70845477
83beta-Alanine metabolism_Homo sapiens_hsa004100.70095272
84Glioma_Homo sapiens_hsa052140.69829783
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.67105279
86Type II diabetes mellitus_Homo sapiens_hsa049300.66892139
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66624277
88Gap junction_Homo sapiens_hsa045400.64571236
89Glucagon signaling pathway_Homo sapiens_hsa049220.62753656
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62309155
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61662649
92Endometrial cancer_Homo sapiens_hsa052130.61546723
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59783285
94Chemokine signaling pathway_Homo sapiens_hsa040620.57735767
95Hedgehog signaling pathway_Homo sapiens_hsa043400.57370031
96Pancreatic secretion_Homo sapiens_hsa049720.56598573
97Melanogenesis_Homo sapiens_hsa049160.56528727
98Renal cell carcinoma_Homo sapiens_hsa052110.56518317
99T cell receptor signaling pathway_Homo sapiens_hsa046600.56411859
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56167406
101Chemical carcinogenesis_Homo sapiens_hsa052040.55622029
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55345191
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54557536
104Non-homologous end-joining_Homo sapiens_hsa034500.53860671
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53001476
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52543072
107Peroxisome_Homo sapiens_hsa041460.52540737
108Axon guidance_Homo sapiens_hsa043600.52127274
109TGF-beta signaling pathway_Homo sapiens_hsa043500.51426675
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.49452330
111Wnt signaling pathway_Homo sapiens_hsa043100.48869645
112Caffeine metabolism_Homo sapiens_hsa002320.48582654
113MicroRNAs in cancer_Homo sapiens_hsa052060.47512761
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47074498
115Histidine metabolism_Homo sapiens_hsa003400.46470106
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.46416641
117Notch signaling pathway_Homo sapiens_hsa043300.46400753
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46087688
119Retinol metabolism_Homo sapiens_hsa008300.45936580
120Sphingolipid metabolism_Homo sapiens_hsa006000.45376437
121Type I diabetes mellitus_Homo sapiens_hsa049400.45312279
122Dilated cardiomyopathy_Homo sapiens_hsa054140.44582101
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44536552
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44297828
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43668858
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43579032
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.42614296
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.41114908
129Insulin resistance_Homo sapiens_hsa049310.39403482
130Rap1 signaling pathway_Homo sapiens_hsa040150.39308757
131Non-small cell lung cancer_Homo sapiens_hsa052230.39033307
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38996166
133Other glycan degradation_Homo sapiens_hsa005110.37731303
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37264929
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36731132
136Vibrio cholerae infection_Homo sapiens_hsa051100.36509247
137Alcoholism_Homo sapiens_hsa050340.36028766
138Selenocompound metabolism_Homo sapiens_hsa004500.34863332

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