ZC3H7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.92176500
2gonadal mesoderm development (GO:0007506)4.78920370
3locomotory exploration behavior (GO:0035641)4.35348232
4synaptic vesicle maturation (GO:0016188)4.29636766
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91802664
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.89174271
7focal adhesion assembly (GO:0048041)3.86665890
8cell-substrate adherens junction assembly (GO:0007045)3.86665890
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.86537281
10sodium ion export (GO:0071436)3.79509396
11establishment of nucleus localization (GO:0040023)3.74095565
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.73555508
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.72563158
14cell-substrate junction assembly (GO:0007044)3.64904941
15negative regulation of fatty acid transport (GO:2000192)3.50024585
16cell communication by electrical coupling (GO:0010644)3.44787709
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42299992
18regulation of early endosome to late endosome transport (GO:2000641)3.29868780
19regulation of glucose import in response to insulin stimulus (GO:2001273)3.28917670
20protein retention in ER lumen (GO:0006621)3.26657008
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26142648
22basement membrane organization (GO:0071711)3.23514269
23dendritic spine morphogenesis (GO:0060997)3.22669538
24activation of protein kinase A activity (GO:0034199)3.22216849
25glial cell proliferation (GO:0014009)3.19046112
26regulation of synapse structural plasticity (GO:0051823)3.18804541
27peptidyl-lysine dimethylation (GO:0018027)3.09398685
28cell migration in hindbrain (GO:0021535)3.09229058
29positive regulation of synapse maturation (GO:0090129)3.09086244
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08722092
31Golgi transport vesicle coating (GO:0048200)3.07577961
32COPI coating of Golgi vesicle (GO:0048205)3.07577961
33vocalization behavior (GO:0071625)3.03510951
34plasma membrane repair (GO:0001778)3.01604101
35glutamate secretion (GO:0014047)2.95987207
36negative regulation of cell size (GO:0045792)2.95600647
37exploration behavior (GO:0035640)2.93428440
38neuromuscular process controlling balance (GO:0050885)2.92981017
39protein heterotrimerization (GO:0070208)2.91316223
40dendrite morphogenesis (GO:0048813)2.89872364
41hemidesmosome assembly (GO:0031581)2.89578352
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89192597
43regulation of synaptic vesicle exocytosis (GO:2000300)2.89080173
44skin morphogenesis (GO:0043589)2.83454708
45positive regulation of blood vessel endothelial cell migration (GO:0043536)2.82930695
46stress fiber assembly (GO:0043149)2.80168869
47cerebellar Purkinje cell layer development (GO:0021680)2.79559179
48protein targeting to plasma membrane (GO:0072661)2.79159148
49cellular potassium ion homeostasis (GO:0030007)2.78553479
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.76618629
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76289701
52synaptic vesicle exocytosis (GO:0016079)2.75574985
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74437533
54regulation of glutamate receptor signaling pathway (GO:1900449)2.73791824
55epithelial cell-cell adhesion (GO:0090136)2.73248062
56embryonic foregut morphogenesis (GO:0048617)2.73137236
57activation of Rac GTPase activity (GO:0032863)2.73003366
58negative regulation of potassium ion transmembrane transport (GO:1901380)2.72995695
59endodermal cell differentiation (GO:0035987)2.71822612
60mannose metabolic process (GO:0006013)2.71450263
61proline transport (GO:0015824)2.71231113
62negative regulation of catenin import into nucleus (GO:0035414)2.71182423
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69744610
64pre-miRNA processing (GO:0031054)2.68184002
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67192821
66convergent extension (GO:0060026)2.67051353
67regulation of ARF protein signal transduction (GO:0032012)2.66389924
68regulation of extracellular matrix disassembly (GO:0010715)2.66129213
69cell-cell junction maintenance (GO:0045217)2.64973898
70regulation of NFAT protein import into nucleus (GO:0051532)2.64920170
71negative regulation of erythrocyte differentiation (GO:0045647)2.64526141
72endothelial cell chemotaxis (GO:0035767)2.63555888
73regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63249487
74cell communication involved in cardiac conduction (GO:0086065)2.62373096
75cardiac myofibril assembly (GO:0055003)2.62184968
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.61939859
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.60523917
78vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.59688215
79adherens junction assembly (GO:0034333)2.58191797
80regulation of neuronal synaptic plasticity (GO:0048168)2.58016332
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57342705
82regulation of clathrin-mediated endocytosis (GO:2000369)2.57033373
83neurotransmitter secretion (GO:0007269)2.56305460
84regulation of establishment of planar polarity (GO:0090175)2.53927314
85cortical actin cytoskeleton organization (GO:0030866)2.53903004
86growth hormone secretion (GO:0030252)2.52426705
87regulation of ARF GTPase activity (GO:0032312)2.49892653
88apoptotic process involved in morphogenesis (GO:0060561)2.49617151
89barbed-end actin filament capping (GO:0051016)2.49420664
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48300045
91cerebellar granule cell differentiation (GO:0021707)2.46140097
92membrane repolarization (GO:0086009)2.46057123
93chondrocyte proliferation (GO:0035988)2.45666173
94vascular endothelial growth factor signaling pathway (GO:0038084)2.45355497
95axonal fasciculation (GO:0007413)2.44969955
96sex determination (GO:0007530)2.44755364
97regulation of dendritic spine morphogenesis (GO:0061001)2.44190597
98regulation of long-term neuronal synaptic plasticity (GO:0048169)2.43904076
99positive regulation of axon extension (GO:0045773)2.43722048
100bone trabecula formation (GO:0060346)2.43559336
101establishment of apical/basal cell polarity (GO:0035089)2.43512710
102cytoplasmic mRNA processing body assembly (GO:0033962)2.43001207
103positive regulation of dendrite morphogenesis (GO:0050775)2.42714493
104ovulation cycle (GO:0042698)2.42080727
105neural tube development (GO:0021915)2.41480532
106axon extension (GO:0048675)2.40272704
107maternal placenta development (GO:0001893)2.40188989
108eye morphogenesis (GO:0048592)2.39955947
109activation of MAPKKK activity (GO:0000185)2.39330613
110potassium ion import (GO:0010107)2.39220271
111endocytic recycling (GO:0032456)2.38697620
112atrioventricular valve morphogenesis (GO:0003181)2.38056128
113regulation of synaptic vesicle transport (GO:1902803)2.37682435
114embryonic eye morphogenesis (GO:0048048)2.36915873
115cell volume homeostasis (GO:0006884)2.36381544
116clathrin coat assembly (GO:0048268)2.36312488
117polarized epithelial cell differentiation (GO:0030859)2.36302539
118positive regulation of male gonad development (GO:2000020)2.35845196
119cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35630563
120negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.35407479
121macroautophagy (GO:0016236)2.33841234
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.33798606
123blood vessel endothelial cell migration (GO:0043534)2.33609103
124cellular response to epidermal growth factor stimulus (GO:0071364)2.33530678
125amino acid import (GO:0043090)2.33192088
126stress granule assembly (GO:0034063)2.32949374
127neuron recognition (GO:0008038)2.32612254
128innervation (GO:0060384)2.31918822
129apoptotic cell clearance (GO:0043277)2.31746154
130nucleus localization (GO:0051647)2.31576639
131negative regulation of organelle assembly (GO:1902116)2.31279203
132protein localization to endosome (GO:0036010)2.31193056
133ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30950900
134membrane repolarization during action potential (GO:0086011)2.30664339
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30620504
136regulation of cholesterol homeostasis (GO:2000188)2.30594897
137G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.30138618
138camera-type eye morphogenesis (GO:0048593)2.30069091
139anatomical structure regression (GO:0060033)2.30050358
140signal complex assembly (GO:0007172)2.29822790
141paraxial mesoderm development (GO:0048339)2.28793980
142positive regulation of receptor recycling (GO:0001921)2.28728550
143cellular sodium ion homeostasis (GO:0006883)2.28478378
144positive regulation of dendrite development (GO:1900006)2.28468051
145actin filament bundle organization (GO:0061572)2.27913682
146actin filament bundle assembly (GO:0051017)2.27913682
147protein localization to synapse (GO:0035418)2.27668929
148glucocorticoid receptor signaling pathway (GO:0042921)2.27543361
149embryonic process involved in female pregnancy (GO:0060136)2.26260554
150neuromuscular junction development (GO:0007528)2.25819041
151cortical cytoskeleton organization (GO:0030865)2.25605337
152establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25332943
153negative regulation of chondrocyte differentiation (GO:0032331)2.25211760
154hippo signaling (GO:0035329)2.24868433
155dendritic spine organization (GO:0097061)2.24802136
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24786401
157collagen fibril organization (GO:0030199)2.24049559
158cell migration involved in heart development (GO:0060973)2.23774431
159proline biosynthetic process (GO:0006561)2.23753081
160auditory behavior (GO:0031223)2.23475044
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23345613
162regulation of fatty acid beta-oxidation (GO:0031998)2.22480150
163adhesion of symbiont to host (GO:0044406)2.22436941
164regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22340107
165endothelial cell morphogenesis (GO:0001886)2.21301134
166adherens junction organization (GO:0034332)2.21208487
167negative regulation of microtubule polymerization (GO:0031115)2.20768953
168gamma-aminobutyric acid transport (GO:0015812)2.19390506
169cell adhesion mediated by integrin (GO:0033627)2.19355320
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18986756
171vesicle transport along microtubule (GO:0047496)2.18981805
172embryonic camera-type eye morphogenesis (GO:0048596)2.18529613
173regulation of hippo signaling (GO:0035330)2.18444190
174semaphorin-plexin signaling pathway (GO:0071526)2.18293418
175extracellular matrix assembly (GO:0085029)2.17701085
176negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17437485
177positive regulation of osteoblast proliferation (GO:0033690)2.16898522
178myelination in peripheral nervous system (GO:0022011)2.16734789
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16697441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.40553723
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.06755573
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97273008
4EZH2_22144423_ChIP-Seq_EOC_Human2.85273638
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.64628966
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.43444292
7KDM2B_26808549_Chip-Seq_K562_Human2.33702703
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26228290
9DROSHA_22980978_ChIP-Seq_HELA_Human2.24501743
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.23984423
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23391202
12KDM2B_26808549_Chip-Seq_DND41_Human2.15474225
13* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.12885050
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.04593095
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00346532
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00346532
17* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.99239163
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.99109860
19ZNF263_19887448_ChIP-Seq_K562_Human1.97690107
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94964895
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93526524
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88237381
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86817859
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86755002
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.86383757
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86106201
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84799487
28VDR_21846776_ChIP-Seq_THP-1_Human1.81454970
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78798847
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78607416
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76586394
32LXR_22292898_ChIP-Seq_THP-1_Human1.74858979
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.74193506
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73832490
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.70762251
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69831042
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68354025
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68088631
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60133503
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58928102
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57835338
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56545930
43TCF7_22412390_ChIP-Seq_EML_Mouse1.55032966
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55001470
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.54336961
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52379795
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.52364811
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.52204809
49CREB1_26743006_Chip-Seq_LNCaP_Human1.50124104
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49746229
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49183714
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45666652
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44003904
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43854811
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43531134
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43497967
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38803379
58* TP53_22127205_ChIP-Seq_IMR90_Human1.38028984
59CLOCK_20551151_ChIP-Seq_293T_Human1.37569626
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36762609
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.36591817
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36454628
63* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34480412
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34223406
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.32257898
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31252681
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30750429
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30656819
69REST_21632747_ChIP-Seq_MESCs_Mouse1.30128995
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.29298722
71RACK7_27058665_Chip-Seq_MCF-7_Human1.29291250
72* MYC_22102868_ChIP-Seq_BL_Human1.28295242
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.28171970
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.27123458
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.25752440
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24879138
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.23645325
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22978678
79P68_20966046_ChIP-Seq_HELA_Human1.22371475
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20979247
81* ISL1_27105846_Chip-Seq_CPCs_Mouse1.20618446
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18146399
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16263874
84* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16162169
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14512784
86CTCF_27219007_Chip-Seq_Bcells_Human1.13865315
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.12707671
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.12041168
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11361100
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10732178
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10178474
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.10132843
93SMC4_20622854_ChIP-Seq_HELA_Human1.09226302
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.09044734
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08834752
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08618828
97* AR_19668381_ChIP-Seq_PC3_Human1.08090587
98* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07255855
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05747319
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05488690
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.05436912
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05250152
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05040490
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04815299
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04712303
106* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04279753
107* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04279753
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03705681
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03161827
110ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03091859
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.02858907
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02453999
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02450060
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01257319
115* EP300_21415370_ChIP-Seq_HL-1_Mouse1.00475414
116ATF3_27146783_Chip-Seq_COLON_Human0.99731069
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99165192
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97793685
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96526334
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.96263483
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.95835054
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95766866
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94673966
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.94648154
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94050494
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93853740
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93483985
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93047706
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92629071
130ZNF274_21170338_ChIP-Seq_K562_Hela0.92448290
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91306973
132KLF4_19829295_ChIP-Seq_ESCs_Human0.91174662
133AHR_22903824_ChIP-Seq_MCF-7_Human0.91168588
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90462882
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90100344
136TP63_22573176_ChIP-Seq_HFKS_Human0.89739100
137SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89735192
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89003212
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88684033
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.88622670
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.88270310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72891245
2MP0003566_abnormal_cell_adhesion2.89958791
3MP0003705_abnormal_hypodermis_morpholog2.82897105
4MP0009780_abnormal_chondrocyte_physiolo2.81192721
5MP0003283_abnormal_digestive_organ2.75855035
6MP0005257_abnormal_intraocular_pressure2.69498984
7MP0003279_aneurysm2.64966163
8MP0005623_abnormal_meninges_morphology2.63971819
9MP0004858_abnormal_nervous_system2.44140335
10MP0000751_myopathy2.41002898
11MP0003635_abnormal_synaptic_transmissio2.39186439
12MP0005409_darkened_coat_color2.23946921
13MP0005503_abnormal_tendon_morphology2.18932747
14MP0004270_analgesia2.14485391
15MP0008961_abnormal_basal_metabolism2.07939434
16MP0005275_abnormal_skin_tensile2.02738103
17MP0010368_abnormal_lymphatic_system2.00287750
18MP0004233_abnormal_muscle_weight1.98693140
19MP0000537_abnormal_urethra_morphology1.95489269
20MP0005076_abnormal_cell_differentiation1.90663496
21MP0002063_abnormal_learning/memory/cond1.86159540
22MP0000569_abnormal_digit_pigmentation1.85095421
23MP0004084_abnormal_cardiac_muscle1.83963995
24MP0004885_abnormal_endolymph1.78711064
25MP0010234_abnormal_vibrissa_follicle1.76340145
26MP0002909_abnormal_adrenal_gland1.75780244
27MP0002249_abnormal_larynx_morphology1.63214079
28MP0009384_cardiac_valve_regurgitation1.61579195
29MP0000778_abnormal_nervous_system1.55525959
30MP0005187_abnormal_penis_morphology1.54994828
31MP0003329_amyloid_beta_deposits1.53389428
32MP0000566_synostosis1.53149485
33MP0005451_abnormal_body_composition1.50674857
34MP0000767_abnormal_smooth_muscle1.49129945
35MP0002653_abnormal_ependyma_morphology1.45882524
36MP0004811_abnormal_neuron_physiology1.45326690
37MP0003119_abnormal_digestive_system1.43320491
38MP0003115_abnormal_respiratory_system1.41389491
39MP0000534_abnormal_ureter_morphology1.39478766
40MP0000678_abnormal_parathyroid_gland1.39222432
41MP0003045_fibrosis1.38900096
42MP0005023_abnormal_wound_healing1.38867650
43MP0003879_abnormal_hair_cell1.38244474
44MP0002234_abnormal_pharynx_morphology1.38070617
45MP0009745_abnormal_behavioral_response1.33797105
46MP0002060_abnormal_skin_morphology1.32242696
47MP0008995_early_reproductive_senescence1.31090119
48MP0005508_abnormal_skeleton_morphology1.30940190
49MP0002064_seizures1.30742525
50MP0001849_ear_inflammation1.30570748
51MP0001348_abnormal_lacrimal_gland1.30494291
52MP0000955_abnormal_spinal_cord1.30190221
53MP0003122_maternal_imprinting1.29486649
54MP0004130_abnormal_muscle_cell1.28735371
55MP0004087_abnormal_muscle_fiber1.27300098
56MP0002837_dystrophic_cardiac_calcinosis1.22828368
57MP0005058_abnormal_lysosome_morphology1.20780762
58MP0005423_abnormal_somatic_nervous1.19803360
59MP0004272_abnormal_basement_membrane1.19653321
60MP0002572_abnormal_emotion/affect_behav1.19234081
61MP0003300_gastrointestinal_ulcer1.18735309
62MP0000733_abnormal_muscle_development1.16929638
63MP0003123_paternal_imprinting1.14643888
64MP0008569_lethality_at_weaning1.11851935
65MP0003878_abnormal_ear_physiology1.11677699
66MP0005377_hearing/vestibular/ear_phenot1.11677699
67MP0009046_muscle_twitch1.11506383
68MP0000428_abnormal_craniofacial_morphol1.10464542
69MP0000462_abnormal_digestive_system1.10150360
70MP0003942_abnormal_urinary_system1.09973175
71MP0001915_intracranial_hemorrhage1.09266933
72MP0006138_congestive_heart_failure1.08584280
73MP0009278_abnormal_bone_marrow1.08294830
74MP0004036_abnormal_muscle_relaxation1.08216709
75MP0004145_abnormal_muscle_electrophysio1.07363481
76MP0005248_abnormal_Harderian_gland1.06499583
77MP0002108_abnormal_muscle_morphology1.06427292
78MP0001958_emphysema1.05774379
79MP0002152_abnormal_brain_morphology1.05602456
80MP0001440_abnormal_grooming_behavior1.05597149
81MP0003861_abnormal_nervous_system1.04880172
82MP0002184_abnormal_innervation1.03362040
83MP0000003_abnormal_adipose_tissue1.02597554
84MP0002089_abnormal_postnatal_growth/wei1.02189627
85MP0001299_abnormal_eye_distance/1.00894571
86MP0003453_abnormal_keratinocyte_physiol1.00609998
87MP0010630_abnormal_cardiac_muscle1.00585282
88MP0000747_muscle_weakness1.00288234
89MP0000013_abnormal_adipose_tissue0.99622752
90MP0009053_abnormal_anal_canal0.98707368
91MP0003385_abnormal_body_wall0.98651207
92MP0004185_abnormal_adipocyte_glucose0.98028231
93MP0000762_abnormal_tongue_morphology0.97911587
94MP0003787_abnormal_imprinting0.97435616
95MP0005167_abnormal_blood-brain_barrier0.97396769
96MP0000579_abnormal_nail_morphology0.97076715
97MP0009840_abnormal_foam_cell0.96900096
98MP0002733_abnormal_thermal_nociception0.95824934
99MP0002734_abnormal_mechanical_nocicepti0.95504503
100MP0002896_abnormal_bone_mineralization0.95465972
101MP0003137_abnormal_impulse_conducting0.95041228
102MP0002882_abnormal_neuron_morphology0.95039968
103MP0002822_catalepsy0.94468172
104MP0003172_abnormal_lysosome_physiology0.94071337
105MP0001486_abnormal_startle_reflex0.93637917
106MP0003091_abnormal_cell_migration0.88874015
107MP0010030_abnormal_orbit_morphology0.88078075
108MP0004215_abnormal_myocardial_fiber0.87188777
109MP0000467_abnormal_esophagus_morphology0.87082592
110MP0003935_abnormal_craniofacial_develop0.86818520
111MP0002084_abnormal_developmental_patter0.86538346
112MP0004197_abnormal_fetal_growth/weight/0.86411021
113MP0005375_adipose_tissue_phenotype0.86059170
114MP0000432_abnormal_head_morphology0.85999868
115MP0002116_abnormal_craniofacial_bone0.85542523
116MP0004085_abnormal_heartbeat0.83916721
117MP0008438_abnormal_cutaneous_collagen0.83816382
118MP0002557_abnormal_social/conspecific_i0.83696014
119MP0005621_abnormal_cell_physiology0.83622905
120MP0002269_muscular_atrophy0.83473574
121MP0002925_abnormal_cardiovascular_devel0.83347625
122MP0002272_abnormal_nervous_system0.83181555
123MP0002877_abnormal_melanocyte_morpholog0.82971428
124MP0003941_abnormal_skin_development0.82362890
125MP0010352_gastrointestinal_tract_polyps0.81341357
126MP0002932_abnormal_joint_morphology0.79504022
127MP0000759_abnormal_skeletal_muscle0.79104302
128MP0001614_abnormal_blood_vessel0.78348230
129MP0002066_abnormal_motor_capabilities/c0.78169306
130MP0005330_cardiomyopathy0.77402913
131MP0009672_abnormal_birth_weight0.77121928
132MP0003634_abnormal_glial_cell0.76930479
133MP0005595_abnormal_vascular_smooth0.76460374
134MP0005666_abnormal_adipose_tissue0.75991082
135MP0001730_embryonic_growth_arrest0.74955083
136MP0002114_abnormal_axial_skeleton0.69719771
137MP0009250_abnormal_appendicular_skeleto0.67920692
138MP0002998_abnormal_bone_remodeling0.66966923
139MP0002128_abnormal_blood_circulation0.66074404
140MP0008260_abnormal_autophagy0.66038970
141MP0000604_amyloidosis0.65899170
142MP0002796_impaired_skin_barrier0.64026335
143MP0003690_abnormal_glial_cell0.62955463
144MP0002697_abnormal_eye_size0.62879586
145MP0005670_abnormal_white_adipose0.62446520
146MP0000920_abnormal_myelination0.62375906
147MP0002113_abnormal_skeleton_development0.61995978

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.39542846
2Hyperacusis (HP:0010780)3.66005009
3Abnormality of the lower motor neuron (HP:0002366)3.52934064
4Insomnia (HP:0100785)3.28619997
5Elfin facies (HP:0004428)3.05482304
6Myokymia (HP:0002411)2.98378926
7Renal duplication (HP:0000075)2.96955083
8Renovascular hypertension (HP:0100817)2.89593262
9Shallow orbits (HP:0000586)2.85421011
10Upper limb amyotrophy (HP:0009129)2.80338535
11Distal upper limb amyotrophy (HP:0007149)2.80338535
12Ulnar bowing (HP:0003031)2.80083600
13Vascular tortuosity (HP:0004948)2.79769511
14Ankle clonus (HP:0011448)2.77545866
15Cerebral aneurysm (HP:0004944)2.75967125
16Overriding aorta (HP:0002623)2.74928802
17Macroorchidism (HP:0000053)2.73312384
18Broad face (HP:0000283)2.72617976
19Pointed chin (HP:0000307)2.72421623
20Arterial tortuosity (HP:0005116)2.72131520
21Aortic aneurysm (HP:0004942)2.70507559
22Hand muscle atrophy (HP:0009130)2.67611740
23Spinal rigidity (HP:0003306)2.67406090
24Lymphangioma (HP:0100764)2.66489652
25Fragile skin (HP:0001030)2.63726887
26Atrophic scars (HP:0001075)2.61275653
27Bladder diverticulum (HP:0000015)2.59877707
28Disproportionate tall stature (HP:0001519)2.56047958
29Aortic dissection (HP:0002647)2.55513592
30Wormian bones (HP:0002645)2.49950184
31Neonatal short-limb short stature (HP:0008921)2.46578051
32Male infertility (HP:0003251)2.46173313
33Cervical subluxation (HP:0003308)2.42703977
34Mitral regurgitation (HP:0001653)2.39002941
35Visual hallucinations (HP:0002367)2.37327175
36Bowel diverticulosis (HP:0005222)2.33919087
37Blue sclerae (HP:0000592)2.33725951
38Flat cornea (HP:0007720)2.32110500
39Ankle contracture (HP:0006466)2.31767507
40Neoplasm of the heart (HP:0100544)2.31397440
41Protrusio acetabuli (HP:0003179)2.30034792
42Insidious onset (HP:0003587)2.27298014
43Termporal pattern (HP:0011008)2.27298014
44Distal lower limb amyotrophy (HP:0008944)2.26894211
45Dysmetric saccades (HP:0000641)2.26217126
46Astrocytoma (HP:0009592)2.24739955
47Abnormality of the astrocytes (HP:0100707)2.24739955
48Action tremor (HP:0002345)2.22661493
49Vertebral compression fractures (HP:0002953)2.22632164
50Turricephaly (HP:0000262)2.22265034
51Biconcave vertebral bodies (HP:0004586)2.20883442
52Increased connective tissue (HP:0009025)2.20479481
53Asymmetry of the thorax (HP:0001555)2.19027400
54Focal seizures (HP:0007359)2.16922071
55Dilatation of the ascending aorta (HP:0005111)2.16696507
56Bundle branch block (HP:0011710)2.15949484
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14281620
58Short 4th metacarpal (HP:0010044)2.14281620
59Ankyloglossia (HP:0010296)2.14188252
60Broad metatarsal (HP:0001783)2.13112701
61Testicular neoplasm (HP:0010788)2.12947656
62Mildly elevated creatine phosphokinase (HP:0008180)2.12645623
63Difficulty running (HP:0009046)2.12423908
64Enlarged penis (HP:0000040)2.12183583
65Supranuclear gaze palsy (HP:0000605)2.11184326
66Ventricular fibrillation (HP:0001663)2.10166564
67Abnormality of dentin (HP:0010299)2.09875211
68Thin bony cortex (HP:0002753)2.08431544
69Abnormality of the 4th metacarpal (HP:0010012)2.08050879
70Annular pancreas (HP:0001734)2.06742570
71Depression (HP:0000716)2.03892514
72Bronchomalacia (HP:0002780)2.03545785
73Hyperextensible skin (HP:0000974)2.01561290
74Neurofibrillary tangles (HP:0002185)2.01346226
75Hypoventilation (HP:0002791)2.00762933
76Increased variability in muscle fiber diameter (HP:0003557)1.99813557
77Germ cell neoplasia (HP:0100728)1.99302101
78Buphthalmos (HP:0000557)1.99092359
79Overgrowth (HP:0001548)1.99009762
80Type 1 muscle fiber predominance (HP:0003803)1.98763988
81Joint laxity (HP:0001388)1.98002855
82Urinary urgency (HP:0000012)1.96377696
83Megalencephaly (HP:0001355)1.95675702
84Subacute progressive viral hepatitis (HP:0006572)1.95631860
85Amyotrophic lateral sclerosis (HP:0007354)1.94794736
86Resting tremor (HP:0002322)1.94421835
87Soft skin (HP:0000977)1.94230575
88Aplasia involving bones of the upper limbs (HP:0009823)1.93950233
89Aplasia of the phalanges of the hand (HP:0009802)1.93950233
90Aplasia involving bones of the extremities (HP:0009825)1.93950233
91Urinary bladder sphincter dysfunction (HP:0002839)1.92563862
92Hemiplegia (HP:0002301)1.92309346
93Flat acetabular roof (HP:0003180)1.92185978
94Long palpebral fissure (HP:0000637)1.92018215
95Cerebral inclusion bodies (HP:0100314)1.90485247
96Abnormality of the diencephalon (HP:0010662)1.90340811
97Fibroma (HP:0010614)1.88287172
98Hyporeflexia of lower limbs (HP:0002600)1.87380822
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.87224424
100Hallux valgus (HP:0001822)1.87050401
101Premature skin wrinkling (HP:0100678)1.86355530
102Advanced eruption of teeth (HP:0006288)1.85881917
103Deviation of the hallux (HP:0010051)1.85836889
104Abnormal social behavior (HP:0012433)1.85431060
105Impaired social interactions (HP:0000735)1.85431060
106Sudden death (HP:0001699)1.85398903
107Natal tooth (HP:0000695)1.85295813
108Wide anterior fontanel (HP:0000260)1.85243645
109Stridor (HP:0010307)1.81252121
110Dislocated radial head (HP:0003083)1.80645034
111Fibrous tissue neoplasm (HP:0012316)1.80627322
112Aneurysm (HP:0002617)1.80355950
113Obsessive-compulsive behavior (HP:0000722)1.80355136
114Intellectual disability, profound (HP:0002187)1.78652351
115Thin ribs (HP:0000883)1.78325790
116Sacral dimple (HP:0000960)1.77826761
117Mitral valve prolapse (HP:0001634)1.77788168
118Short nail (HP:0001799)1.77598079
119Abnormal ossification of hand bones (HP:0005921)1.77214977
120Lower limb amyotrophy (HP:0007210)1.76915125
121Papilledema (HP:0001085)1.76265516
122Camptodactyly of toe (HP:0001836)1.75764314
123Rectal prolapse (HP:0002035)1.75273414
124Achilles tendon contracture (HP:0001771)1.74982384
125Genetic anticipation (HP:0003743)1.74087610
126Hypercortisolism (HP:0001578)1.73235044
127Increased nuchal translucency (HP:0010880)1.73222363
128Impaired vibration sensation in the lower limbs (HP:0002166)1.72845136
129Spinal cord compression (HP:0002176)1.72679270
130Ependymoma (HP:0002888)1.72545475
131Pseudobulbar signs (HP:0002200)1.72327225
132Long eyelashes (HP:0000527)1.71920148
133Poor eye contact (HP:0000817)1.71659370
134Deep venous thrombosis (HP:0002625)1.71612760
135Abnormality of oral frenula (HP:0000190)1.70557397
136Abnormality of the radial head (HP:0003995)1.70417725
137Torticollis (HP:0000473)1.69110890
138Persistence of primary teeth (HP:0006335)1.68446341
139Patellar dislocation (HP:0002999)1.67933171
140Heterotopia (HP:0002282)1.67882050
141Hamartoma of the eye (HP:0010568)1.66971451
142Vertebral arch anomaly (HP:0008438)1.66900372
143Bowed forearm bones (HP:0003956)1.66826601
144Bowing of the arm (HP:0006488)1.66826601
145Syringomyelia (HP:0003396)1.64974896
146Spinal cord lesions (HP:0100561)1.64974896
147Hepatoblastoma (HP:0002884)1.64821465
148Arnold-Chiari malformation (HP:0002308)1.64010868
149Coronal craniosynostosis (HP:0004440)1.63064020
150Megalocornea (HP:0000485)1.62682011
151Coxa vara (HP:0002812)1.62261301
152Mild short stature (HP:0003502)1.62254024
153Abnormality of the Achilles tendon (HP:0005109)1.61893912
154Precocious puberty (HP:0000826)1.60964219
155Back pain (HP:0003418)1.60721048
156Clonus (HP:0002169)1.58984871
157Obstructive sleep apnea (HP:0002870)1.58848285
158Abnormality of skeletal muscle fiber size (HP:0012084)1.58164156
159Genu recurvatum (HP:0002816)1.58052352
160Postural instability (HP:0002172)1.57897684
161Apathy (HP:0000741)1.57470184
162Exercise-induced myalgia (HP:0003738)1.56887469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.85553767
2PRPF4B3.12019517
3SMG12.98184224
4PKN22.80694956
5PRKD32.78192323
6RIPK12.64152083
7TYRO32.63193922
8MAP3K92.49176238
9MARK12.47117827
10ICK2.36354442
11FGFR42.22066998
12EEF2K2.19833228
13PAK62.10904778
14PDGFRA2.09539877
15MAP3K101.97234505
16DAPK21.91662427
17CDK121.87552277
18KSR21.86262535
19LATS21.86155547
20MAP3K41.80615987
21NTRK31.80517935
22MINK11.53700020
23PTK61.53197296
24DDR21.51862176
25CAMKK11.50552410
26TTN1.46903655
27NTRK21.46199761
28NTRK11.45627251
29ALK1.43310620
30EPHA41.43169225
31LMTK21.42166296
32PHKG11.37067769
33PHKG21.37067769
34RET1.28808753
35SIK21.28358813
36IRAK31.27748489
37KSR11.27611452
38LATS11.24478449
39CAMK1G1.21594457
40SCYL21.18450593
41TAOK11.17672054
42BMX1.17073506
43DMPK1.13370097
44STK381.11658787
45NEK11.09601586
46PAK31.07578469
47EPHA21.04050367
48UHMK11.03392431
49MTOR1.01777704
50CDC42BPA1.00679445
51MAP3K21.00296831
52PRKCH0.98999250
53SIK10.98853556
54MAP3K130.95969390
55FGFR20.89983306
56PTK20.88855790
57EPHB20.88173568
58CDK50.88059336
59WNK10.86570696
60MAP2K40.84496869
61CAMK1D0.83617185
62STK110.81567696
63MET0.80900799
64PAK20.78712781
65PDGFRB0.76952578
66MARK20.75942900
67FGFR30.75363540
68MAP3K70.74936719
69TESK10.68730496
70TAOK20.67517025
71RPS6KC10.66893654
72RPS6KL10.66893654
73FGFR10.66846182
74DAPK10.65069539
75PAK40.63564616
76MST1R0.63248217
77ERBB20.63129710
78HIPK20.62377500
79ARAF0.60724407
80WNK40.59415448
81FER0.59178355
82SGK30.58990207
83CDK150.58099717
84RPS6KA20.57331441
85NEK90.55095498
86PRKG20.55009993
87MAP3K60.54920146
88PRKD10.54430036
89CDK140.53196857
90MYLK0.52979965
91MAPK110.52759459
92CDK180.52341918
93ROCK10.52104271
94BRD40.51343310
95MAP3K10.50306185
96CSNK1G20.49855370
97PTK2B0.49646292
98EPHB10.49195038
99CDK11A0.49193446
100TRPM70.49094289
101WNK30.48796676
102MAPK120.48430819
103CAMK40.46755970
104ERN10.46649261
105RPS6KA30.46420128
106PRKD20.46353860
107RPS6KA60.45898888
108MAP2K30.44283845
109MAP2K20.42720132
110CSNK1A1L0.42031565
111PRKCZ0.40802795
112SGK10.40503066
113ILK0.39629080
114MAPK100.38978842
115LRRK20.38855500
116JAK10.38781265
117CDK60.38724816
118MAP3K80.37750080
119DYRK1B0.37715019
120MOS0.36906943
121CDK40.36852793
122PDPK10.36345663
123MAPK80.36161276
124MAPK70.36052884
125PRKAA10.35929408
126FYN0.35454603
127CSNK1D0.35204834
128ROCK20.35185921
129PDK30.35140408
130PDK40.35140408
131SGK2230.35065069
132SGK4940.35065069
133BRAF0.34561555
134PDK10.33597086
135MAP3K30.32648003
136CDK70.32202089

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07862021
2Nitrogen metabolism_Homo sapiens_hsa009102.06903560
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80167446
4Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63689343
5Prion diseases_Homo sapiens_hsa050201.61946090
6Long-term potentiation_Homo sapiens_hsa047201.60296427
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56401596
8Circadian entrainment_Homo sapiens_hsa047131.55891274
9Glioma_Homo sapiens_hsa052141.49960223
10Gastric acid secretion_Homo sapiens_hsa049711.48948482
11Synaptic vesicle cycle_Homo sapiens_hsa047211.45613389
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45442618
13Olfactory transduction_Homo sapiens_hsa047401.45226522
14Estrogen signaling pathway_Homo sapiens_hsa049151.43647405
15Type II diabetes mellitus_Homo sapiens_hsa049301.43017276
16Axon guidance_Homo sapiens_hsa043601.42899916
17Dorso-ventral axis formation_Homo sapiens_hsa043201.41125334
18mTOR signaling pathway_Homo sapiens_hsa041501.40359174
19GABAergic synapse_Homo sapiens_hsa047271.39667603
20Dopaminergic synapse_Homo sapiens_hsa047281.35602534
21Glutamatergic synapse_Homo sapiens_hsa047241.35009224
22Insulin secretion_Homo sapiens_hsa049111.34707421
23Dilated cardiomyopathy_Homo sapiens_hsa054141.33859946
24Gap junction_Homo sapiens_hsa045401.31799359
25Amphetamine addiction_Homo sapiens_hsa050311.28991037
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28889019
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27510417
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27363057
29Oxytocin signaling pathway_Homo sapiens_hsa049211.27058681
30Cholinergic synapse_Homo sapiens_hsa047251.26672611
31Endometrial cancer_Homo sapiens_hsa052131.26595752
32Renin secretion_Homo sapiens_hsa049241.25930454
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24762247
34Salivary secretion_Homo sapiens_hsa049701.24686611
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24062955
36Acute myeloid leukemia_Homo sapiens_hsa052211.24019615
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20429589
38GnRH signaling pathway_Homo sapiens_hsa049121.19606227
39Other glycan degradation_Homo sapiens_hsa005111.17316278
40Small cell lung cancer_Homo sapiens_hsa052221.16037874
41Thyroid cancer_Homo sapiens_hsa052161.16002667
42Morphine addiction_Homo sapiens_hsa050321.14840454
43Focal adhesion_Homo sapiens_hsa045101.14632944
44Pancreatic cancer_Homo sapiens_hsa052121.13674979
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11545647
46Cocaine addiction_Homo sapiens_hsa050301.11196596
47Melanogenesis_Homo sapiens_hsa049161.10479246
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10227830
49Hippo signaling pathway_Homo sapiens_hsa043901.10101111
50Hedgehog signaling pathway_Homo sapiens_hsa043401.09964390
51cAMP signaling pathway_Homo sapiens_hsa040241.08204811
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.07500543
53ErbB signaling pathway_Homo sapiens_hsa040121.06699349
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.06577451
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05339552
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.05305133
57Lysine degradation_Homo sapiens_hsa003101.04523216
58VEGF signaling pathway_Homo sapiens_hsa043701.03487934
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03021849
60Prostate cancer_Homo sapiens_hsa052151.02363523
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01002975
62Chronic myeloid leukemia_Homo sapiens_hsa052201.00831468
63Proteoglycans in cancer_Homo sapiens_hsa052051.00517553
64Non-small cell lung cancer_Homo sapiens_hsa052231.00354636
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00308238
66Basal cell carcinoma_Homo sapiens_hsa052170.99674380
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.99042260
68Fatty acid biosynthesis_Homo sapiens_hsa000610.98400577
69Insulin signaling pathway_Homo sapiens_hsa049100.97308082
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.97170305
71Nicotine addiction_Homo sapiens_hsa050330.96353340
72Renal cell carcinoma_Homo sapiens_hsa052110.95390158
73Tight junction_Homo sapiens_hsa045300.93141469
74Bile secretion_Homo sapiens_hsa049760.92135365
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90908923
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90277940
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90166332
78Inositol phosphate metabolism_Homo sapiens_hsa005620.90016028
79Insulin resistance_Homo sapiens_hsa049310.89810336
80Notch signaling pathway_Homo sapiens_hsa043300.89625491
81Colorectal cancer_Homo sapiens_hsa052100.88939464
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87951638
83Glucagon signaling pathway_Homo sapiens_hsa049220.87871931
84Long-term depression_Homo sapiens_hsa047300.87429425
85Oocyte meiosis_Homo sapiens_hsa041140.86341929
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85516097
87Adherens junction_Homo sapiens_hsa045200.85435588
88ECM-receptor interaction_Homo sapiens_hsa045120.84146756
89Vitamin B6 metabolism_Homo sapiens_hsa007500.84064147
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83954313
91AMPK signaling pathway_Homo sapiens_hsa041520.83437998
92Amoebiasis_Homo sapiens_hsa051460.82546986
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82041026
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78415338
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.76712805
96Wnt signaling pathway_Homo sapiens_hsa043100.76417486
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75286517
98Rap1 signaling pathway_Homo sapiens_hsa040150.75175196
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73878331
100Choline metabolism in cancer_Homo sapiens_hsa052310.73852848
101Pathways in cancer_Homo sapiens_hsa052000.73748295
102Calcium signaling pathway_Homo sapiens_hsa040200.73008705
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.72996437
104Thyroid hormone synthesis_Homo sapiens_hsa049180.72765942
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71844554
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71573042
107Melanoma_Homo sapiens_hsa052180.71481445
108Arginine biosynthesis_Homo sapiens_hsa002200.71324076
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71295136
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71269896
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70693931
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.68496958
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.67271515
114Endocytosis_Homo sapiens_hsa041440.66843022
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65780228
116Viral myocarditis_Homo sapiens_hsa054160.65095225
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64469915
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64192912
119MAPK signaling pathway_Homo sapiens_hsa040100.64078307
120Prolactin signaling pathway_Homo sapiens_hsa049170.62977665
121MicroRNAs in cancer_Homo sapiens_hsa052060.62964565
122Bladder cancer_Homo sapiens_hsa052190.62829975
123Pentose phosphate pathway_Homo sapiens_hsa000300.62728623
124Protein digestion and absorption_Homo sapiens_hsa049740.61441252
125Biosynthesis of amino acids_Homo sapiens_hsa012300.58221492
126B cell receptor signaling pathway_Homo sapiens_hsa046620.56847343

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