ZC3H8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.51437538
2maturation of SSU-rRNA (GO:0030490)4.72406582
3purine nucleobase biosynthetic process (GO:0009113)4.69466159
4nucleobase biosynthetic process (GO:0046112)4.67065282
5DNA replication checkpoint (GO:0000076)4.47846253
6DNA replication initiation (GO:0006270)4.25584520
7termination of RNA polymerase III transcription (GO:0006386)4.23446504
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.23446504
9DNA strand elongation involved in DNA replication (GO:0006271)4.16985017
10cullin deneddylation (GO:0010388)4.14042293
11mitotic metaphase plate congression (GO:0007080)4.12773331
12protein deneddylation (GO:0000338)4.08695566
13ribosome biogenesis (GO:0042254)4.06838491
14kynurenine metabolic process (GO:0070189)4.05328331
15DNA strand elongation (GO:0022616)4.01968637
16proteasome assembly (GO:0043248)3.96290254
17indole-containing compound catabolic process (GO:0042436)3.92451217
18indolalkylamine catabolic process (GO:0046218)3.92451217
19tryptophan catabolic process (GO:0006569)3.92451217
20telomere maintenance via semi-conservative replication (GO:0032201)3.86888126
21DNA unwinding involved in DNA replication (GO:0006268)3.85854760
227-methylguanosine RNA capping (GO:0009452)3.85001579
23RNA capping (GO:0036260)3.85001579
24maturation of 5.8S rRNA (GO:0000460)3.82504403
25spliceosomal snRNP assembly (GO:0000387)3.82399836
267-methylguanosine mRNA capping (GO:0006370)3.80251923
27CENP-A containing nucleosome assembly (GO:0034080)3.76794355
28water-soluble vitamin biosynthetic process (GO:0042364)3.73717159
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73140481
30transcription elongation from RNA polymerase I promoter (GO:0006362)3.72880458
31ribonucleoprotein complex biogenesis (GO:0022613)3.72439819
32chromatin remodeling at centromere (GO:0031055)3.72166714
33pseudouridine synthesis (GO:0001522)3.71877979
34indolalkylamine metabolic process (GO:0006586)3.71052274
35ribosome assembly (GO:0042255)3.67808877
36protein complex biogenesis (GO:0070271)3.64136262
37rRNA processing (GO:0006364)3.61024847
38ribosomal small subunit assembly (GO:0000028)3.59531400
39formation of translation preinitiation complex (GO:0001731)3.58499826
40termination of RNA polymerase I transcription (GO:0006363)3.57788473
41metaphase plate congression (GO:0051310)3.57010429
42DNA deamination (GO:0045006)3.56440261
43viral mRNA export from host cell nucleus (GO:0046784)3.55810288
44telomere maintenance via recombination (GO:0000722)3.53371966
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50566178
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.50566178
47NADH dehydrogenase complex assembly (GO:0010257)3.50566178
48spliceosomal complex assembly (GO:0000245)3.49802893
49rRNA metabolic process (GO:0016072)3.48526731
50transcription-coupled nucleotide-excision repair (GO:0006283)3.47978458
51transcription from RNA polymerase I promoter (GO:0006360)3.45129174
52rRNA modification (GO:0000154)3.43481305
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.43240666
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42439441
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37971894
56DNA replication-independent nucleosome assembly (GO:0006336)3.37404536
57DNA replication-independent nucleosome organization (GO:0034724)3.37404536
58mitochondrial respiratory chain complex assembly (GO:0033108)3.34672307
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34606283
60mitotic recombination (GO:0006312)3.34286216
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33886514
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33588877
63telomere maintenance via telomere lengthening (GO:0010833)3.33062950
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.28660969
65ribosomal large subunit biogenesis (GO:0042273)3.28238404
66cellular component biogenesis (GO:0044085)3.26509493
67protein K6-linked ubiquitination (GO:0085020)3.25848853
68histone exchange (GO:0043486)3.25696642
69DNA-templated transcription, elongation (GO:0006354)3.25028470
70tryptophan metabolic process (GO:0006568)3.23464418
71transcription elongation from RNA polymerase II promoter (GO:0006368)3.22871577
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.21686047
73nonmotile primary cilium assembly (GO:0035058)3.18731139
74response to pheromone (GO:0019236)3.17425237
75ribosomal small subunit biogenesis (GO:0042274)3.17394495
76IMP biosynthetic process (GO:0006188)3.17100229
77kinetochore assembly (GO:0051382)3.16283027
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16223774
79kinetochore organization (GO:0051383)3.14565930
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14283181
81transcription initiation from RNA polymerase I promoter (GO:0006361)3.14212170
82attachment of spindle microtubules to kinetochore (GO:0008608)3.12499586
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.12474294
84chaperone-mediated protein transport (GO:0072321)3.12147005
85negative regulation of ligase activity (GO:0051352)3.09344188
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09344188
87protein localization to kinetochore (GO:0034501)3.09188317
88gamma-aminobutyric acid transport (GO:0015812)3.08450220
89DNA double-strand break processing (GO:0000729)3.07499010
90ATP synthesis coupled proton transport (GO:0015986)3.07353617
91energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07353617
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.06131868
93negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06131868
94DNA-dependent DNA replication (GO:0006261)3.05254089
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03377350
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01285437
97DNA-templated transcription, termination (GO:0006353)2.99227697
98G1/S transition of mitotic cell cycle (GO:0000082)2.99217891
99cell cycle G1/S phase transition (GO:0044843)2.99217891
100folic acid-containing compound biosynthetic process (GO:0009396)2.99040832
101protein polyglutamylation (GO:0018095)2.98830524
102ncRNA processing (GO:0034470)2.97572126
103regulation of cellular amino acid metabolic process (GO:0006521)2.97468706
104L-fucose catabolic process (GO:0042355)2.97414764
105fucose catabolic process (GO:0019317)2.97414764
106L-fucose metabolic process (GO:0042354)2.97414764
107piRNA metabolic process (GO:0034587)2.97076928
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96910439
109ncRNA metabolic process (GO:0034660)2.96143648
110indole-containing compound metabolic process (GO:0042430)2.95882547
111regulation of transcription from RNA polymerase I promoter (GO:0006356)2.95638404
112detection of light stimulus involved in sensory perception (GO:0050962)2.93989367
113detection of light stimulus involved in visual perception (GO:0050908)2.93989367
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93795382
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93775956
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93775956
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93775956
118cell proliferation in forebrain (GO:0021846)2.93316739
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93087163
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93087163
121primary amino compound metabolic process (GO:1901160)2.93018870
122somite development (GO:0061053)2.92911184
123intra-S DNA damage checkpoint (GO:0031573)2.92652690
124replication fork processing (GO:0031297)2.92390889
125establishment of integrated proviral latency (GO:0075713)2.91584888
126regulation of mitochondrial translation (GO:0070129)2.90673540
127establishment of chromosome localization (GO:0051303)2.89984141
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89763028
129rRNA methylation (GO:0031167)2.89687187
130signal transduction involved in DNA damage checkpoint (GO:0072422)2.89081561
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89081561
132serotonin metabolic process (GO:0042428)2.85476283
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85417368
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83456015
135pyrimidine nucleobase catabolic process (GO:0006208)2.81733187
136regulation of action potential (GO:0098900)2.81179217
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79634476
138transmission of nerve impulse (GO:0019226)2.79390635
139synaptic transmission, cholinergic (GO:0007271)2.79063162
140respiratory chain complex IV assembly (GO:0008535)2.77575452
141cytochrome complex assembly (GO:0017004)2.76246178
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75926750
143protein-cofactor linkage (GO:0018065)2.73564360
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73206253
145regulation of DNA endoreduplication (GO:0032875)2.72026092
146cellular ketone body metabolic process (GO:0046950)2.71548408
147epithelial cilium movement (GO:0003351)2.70119078
148DNA methylation involved in gamete generation (GO:0043046)2.68537132
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68077091
150neuronal action potential (GO:0019228)2.66079357
151cellular biogenic amine catabolic process (GO:0042402)2.64578355
152amine catabolic process (GO:0009310)2.64578355
153cornea development in camera-type eye (GO:0061303)2.63586172
154negative regulation of appetite (GO:0032099)2.63501157
155negative regulation of response to food (GO:0032096)2.63501157
156membrane depolarization during action potential (GO:0086010)2.62582034
157parturition (GO:0007567)2.61238482
158rRNA catabolic process (GO:0016075)2.60502850
159neural tube formation (GO:0001841)2.60338768
160protein neddylation (GO:0045116)2.58189896
161behavioral response to ethanol (GO:0048149)2.57547761
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.57415322
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52673227
164retinal ganglion cell axon guidance (GO:0031290)2.52405662
165axoneme assembly (GO:0035082)2.52217965
166spinal cord motor neuron differentiation (GO:0021522)2.51945832
167male meiosis I (GO:0007141)2.50734792
168kidney morphogenesis (GO:0060993)2.50148114
169regulation of posttranscriptional gene silencing (GO:0060147)2.48249145
170regulation of gene silencing by miRNA (GO:0060964)2.48249145
171regulation of gene silencing by RNA (GO:0060966)2.48249145
172nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47644845
173presynaptic membrane organization (GO:0097090)2.47154368
174recombinational repair (GO:0000725)2.45643236
175double-strand break repair via homologous recombination (GO:0000724)2.44290411
176regulation of mesoderm development (GO:2000380)2.44236648
177positive regulation of protein homodimerization activity (GO:0090073)2.44105679
178ketone body metabolic process (GO:1902224)2.43664957
179rhodopsin mediated signaling pathway (GO:0016056)2.41967741
180negative regulation of telomere maintenance (GO:0032205)2.41563437
181nucleobase catabolic process (GO:0046113)2.40035979
182tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39867655
183RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39867655
184endoderm formation (GO:0001706)2.39756352
185protein localization to cilium (GO:0061512)2.38856193
186electron transport chain (GO:0022900)2.38766140
187reciprocal meiotic recombination (GO:0007131)2.38110239
188reciprocal DNA recombination (GO:0035825)2.38110239
189sulfation (GO:0051923)2.35810532
190synapsis (GO:0007129)2.35612507
191centriole replication (GO:0007099)2.35126891
192negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34209945
193cilium organization (GO:0044782)2.34006764
194sperm motility (GO:0030317)2.33487489
195respiratory electron transport chain (GO:0022904)2.33050177
196neuronal action potential propagation (GO:0019227)2.31979620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.60093579
2EZH2_22144423_ChIP-Seq_EOC_Human5.00235573
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45707675
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30066949
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74665279
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.70917441
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.65413041
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60600427
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.32799909
10ZNF274_21170338_ChIP-Seq_K562_Hela3.32054311
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30154970
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20523155
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15590691
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95669930
15VDR_22108803_ChIP-Seq_LS180_Human2.95165490
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94180019
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88404748
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87402182
19GBX2_23144817_ChIP-Seq_PC3_Human2.73840273
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71224934
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63557268
22* VDR_23849224_ChIP-Seq_CD4+_Human2.63061172
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59685767
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56080432
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48537074
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42257348
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39861537
28FOXP3_21729870_ChIP-Seq_TREG_Human2.37664965
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36269905
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34704831
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33489282
32DCP1A_22483619_ChIP-Seq_HELA_Human2.24645552
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20194740
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20012487
35XRN2_22483619_ChIP-Seq_HELA_Human2.19161942
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14543463
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14327970
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14046512
39IGF1R_20145208_ChIP-Seq_DFB_Human2.12737031
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.12590377
41CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09393778
42* GABP_19822575_ChIP-Seq_HepG2_Human2.08671026
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08271791
44FOXM1_23109430_ChIP-Seq_U2OS_Human2.07151933
45YY1_21170310_ChIP-Seq_MESCs_Mouse2.02668868
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01745391
47* SRF_21415370_ChIP-Seq_HL-1_Mouse2.01254696
48BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00002893
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99799791
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98570304
51TAF15_26573619_Chip-Seq_HEK293_Human1.94513933
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.94419233
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93500132
54TTF2_22483619_ChIP-Seq_HELA_Human1.92717705
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92020626
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87768158
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86448506
58AR_21909140_ChIP-Seq_LNCAP_Human1.86141955
59REST_21632747_ChIP-Seq_MESCs_Mouse1.85909363
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81947746
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81679583
62P300_19829295_ChIP-Seq_ESCs_Human1.80980009
63* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79244119
64ELK1_19687146_ChIP-ChIP_HELA_Human1.78919780
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78474654
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.76494482
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72954424
68ER_23166858_ChIP-Seq_MCF-7_Human1.69495159
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66262033
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65939867
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64988677
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64012096
73* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62836398
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.61527176
75RNF2_27304074_Chip-Seq_NSC_Mouse1.61410403
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55552402
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54707048
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51805342
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49300004
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46236597
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44140225
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43963142
83CIITA_25753668_ChIP-Seq_RAJI_Human1.43805802
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43396732
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43237377
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43237377
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.40824932
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40705897
89CBP_20019798_ChIP-Seq_JUKART_Human1.40705897
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39897636
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39676852
92TP53_22573176_ChIP-Seq_HFKS_Human1.39065027
93MYC_18940864_ChIP-ChIP_HL60_Human1.38112884
94KDM5A_27292631_Chip-Seq_BREAST_Human1.37400851
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36736984
96* TCF4_23295773_ChIP-Seq_U87_Human1.36656690
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36050261
98STAT3_23295773_ChIP-Seq_U87_Human1.35798693
99SMAD4_21799915_ChIP-Seq_A2780_Human1.34570325
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32288312
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31417551
102* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31220389
103IRF1_19129219_ChIP-ChIP_H3396_Human1.30879171
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.30011502
105* AR_25329375_ChIP-Seq_VCAP_Human1.29267779
106AR_21572438_ChIP-Seq_LNCaP_Human1.28577616
107BCAT_22108803_ChIP-Seq_LS180_Human1.28366456
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.27964328
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26473271
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25220541
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24830826
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24534248
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24196515
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.22969359
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22849651
116JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22024345
117REST_18959480_ChIP-ChIP_MESCs_Mouse1.21007840
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20809644
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.19583197
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19254230
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18740525
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18608598
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.17509920
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17136571
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.17136571
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14869372
127NCOR_22424771_ChIP-Seq_293T_Human1.13960373
128* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13844344
129RUNX2_22187159_ChIP-Seq_PCA_Human1.13821702
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13554288
131TCF4_22108803_ChIP-Seq_LS180_Human1.13074466
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.12481281
133SOX2_19829295_ChIP-Seq_ESCs_Human1.11011819
134NANOG_19829295_ChIP-Seq_ESCs_Human1.11011819
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10676927
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10612545
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10009354
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.06984054
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06855509
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.06378648
141RNF2_27304074_Chip-Seq_ESCs_Mouse1.04036139
142SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02979582
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02554762
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01260193
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01102830
146AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00765754
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.99601166
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.99562536
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99509376
150* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99129373
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98827220
152GATA3_21878914_ChIP-Seq_MCF-7_Human0.98797083
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98732421
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98662044
155FLI1_21867929_ChIP-Seq_TH2_Mouse0.98269323
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98153656
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97673030
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97416737
159ELK1_22589737_ChIP-Seq_MCF10A_Human0.96829294
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96674660
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.96387936
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88403513
163FUS_26573619_Chip-Seq_HEK293_Human0.87433428
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86049468
165CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85325544
166EWS_26573619_Chip-Seq_HEK293_Human0.85121313
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85045463
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83250486
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82199796
170CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79661486
171KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79532432
172CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78295555
173ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76598013
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74517172
175* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73978995
176KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73893943
177PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73451074
178PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71530179
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71318875
180* SOX17_20123909_ChIP-Seq_XEN_Mouse0.68304261
181CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67536599
182NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66608254
183TFEB_21752829_ChIP-Seq_HELA_Human0.64832076
184SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.64340992
185* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.62602298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.99308159
2MP0010094_abnormal_chromosome_stability4.42381967
3MP0004957_abnormal_blastocyst_morpholog3.90004626
4MP0003123_paternal_imprinting3.73800055
5MP0008057_abnormal_DNA_replication3.72772589
6MP0008058_abnormal_DNA_repair3.69642127
7MP0003111_abnormal_nucleus_morphology3.66429923
8MP0003077_abnormal_cell_cycle3.55438364
9MP0008877_abnormal_DNA_methylation3.17383097
10MP0003646_muscle_fatigue2.69088284
11MP0008007_abnormal_cellular_replicative2.53041409
12MP0008932_abnormal_embryonic_tissue2.51822689
13MP0006292_abnormal_olfactory_placode2.43599703
14MP0003718_maternal_effect2.40491431
15MP0000569_abnormal_digit_pigmentation2.34697502
16MP0003121_genomic_imprinting2.26961063
17MP0001188_hyperpigmentation2.25395391
18MP0003786_premature_aging2.24498432
19MP0001529_abnormal_vocalization2.17485675
20MP0005551_abnormal_eye_electrophysiolog2.11031662
21MP0002396_abnormal_hematopoietic_system2.07331786
22MP0001968_abnormal_touch/_nociception2.06622263
23MP0009046_muscle_twitch2.01797866
24MP0002272_abnormal_nervous_system1.91308359
25MP0009745_abnormal_behavioral_response1.89390476
26MP0001485_abnormal_pinna_reflex1.88955728
27MP0004885_abnormal_endolymph1.86387156
28MP0004145_abnormal_muscle_electrophysio1.84024761
29MP0000350_abnormal_cell_proliferation1.79842832
30MP0003787_abnormal_imprinting1.79814011
31MP0002210_abnormal_sex_determination1.78655389
32MP0000631_abnormal_neuroendocrine_gland1.74281014
33MP0001730_embryonic_growth_arrest1.68497861
34MP0009697_abnormal_copulation1.66660549
35MP0004742_abnormal_vestibular_system1.55013514
36MP0003890_abnormal_embryonic-extraembry1.53832537
37MP0003880_abnormal_central_pattern1.53073811
38MP0008260_abnormal_autophagy1.52637687
39MP0003195_calcinosis1.51641353
40MP0001929_abnormal_gametogenesis1.51583372
41MP0001905_abnormal_dopamine_level1.51183434
42MP0008875_abnormal_xenobiotic_pharmacok1.47744434
43MP0002736_abnormal_nociception_after1.47563623
44MP0006036_abnormal_mitochondrial_physio1.47371621
45MP0002132_abnormal_respiratory_system1.47214539
46MP0003635_abnormal_synaptic_transmissio1.45340726
47MP0002572_abnormal_emotion/affect_behav1.43622939
48MP0008872_abnormal_physiological_respon1.42607738
49MP0008789_abnormal_olfactory_epithelium1.41837130
50MP0001486_abnormal_startle_reflex1.40832182
51MP0003315_abnormal_perineum_morphology1.40569460
52MP0001145_abnormal_male_reproductive1.40350668
53MP0001986_abnormal_taste_sensitivity1.40165201
54MP0002163_abnormal_gland_morphology1.39427501
55MP0002653_abnormal_ependyma_morphology1.38903465
56MP0002064_seizures1.38775718
57MP0000653_abnormal_sex_gland1.37581882
58MP0005253_abnormal_eye_physiology1.36620547
59MP0005645_abnormal_hypothalamus_physiol1.36161975
60MP0002102_abnormal_ear_morphology1.35252637
61MP0000778_abnormal_nervous_system1.35036074
62MP0002733_abnormal_thermal_nociception1.34664381
63MP0006035_abnormal_mitochondrial_morpho1.34257408
64MP0002557_abnormal_social/conspecific_i1.34192511
65MP0009379_abnormal_foot_pigmentation1.33151652
66MP0002160_abnormal_reproductive_system1.32866885
67MP0002063_abnormal_learning/memory/cond1.31263329
68MP0001697_abnormal_embryo_size1.30582625
69MP0003136_yellow_coat_color1.29093102
70MP0002234_abnormal_pharynx_morphology1.28868515
71MP0002735_abnormal_chemical_nociception1.28163182
72MP0001970_abnormal_pain_threshold1.27824608
73MP0000427_abnormal_hair_cycle1.26461177
74MP0005380_embryogenesis_phenotype1.23911707
75MP0001672_abnormal_embryogenesis/_devel1.23911707
76MP0002184_abnormal_innervation1.23865274
77MP0001984_abnormal_olfaction1.23406561
78MP0002067_abnormal_sensory_capabilities1.20665090
79MP0000313_abnormal_cell_death1.20418315
80MP0002734_abnormal_mechanical_nocicepti1.17951209
81MP0005379_endocrine/exocrine_gland_phen1.15534598
82MP0002638_abnormal_pupillary_reflex1.15433024
83MP0000049_abnormal_middle_ear1.13023714
84MP0004147_increased_porphyrin_level1.12948984
85MP0005075_abnormal_melanosome_morpholog1.12897275
86MP0004133_heterotaxia1.12608317
87MP0001119_abnormal_female_reproductive1.12241231
88MP0005499_abnormal_olfactory_system1.11359237
89MP0005394_taste/olfaction_phenotype1.11359237
90MP0005423_abnormal_somatic_nervous1.11250137
91MP0003122_maternal_imprinting1.10244419
92MP0003011_delayed_dark_adaptation1.10095708
93MP0005389_reproductive_system_phenotype1.09745631
94MP0004130_abnormal_muscle_cell1.09319822
95MP0001440_abnormal_grooming_behavior1.09177601
96MP0002080_prenatal_lethality1.09148561
97MP0003221_abnormal_cardiomyocyte_apopto1.08696145
98MP0000015_abnormal_ear_pigmentation1.08478582
99MP0001501_abnormal_sleep_pattern1.07464977
100MP0002752_abnormal_somatic_nervous1.06801011
101MP0000372_irregular_coat_pigmentation1.06442824
102MP0003698_abnormal_male_reproductive1.05300297
103MP0001963_abnormal_hearing_physiology1.05278415
104MP0003806_abnormal_nucleotide_metabolis1.04896015
105MP0003984_embryonic_growth_retardation1.04775783
106MP0005410_abnormal_fertilization1.04711963
107MP0000026_abnormal_inner_ear1.03260849
108MP0002928_abnormal_bile_duct1.03242195
109MP0005195_abnormal_posterior_eye1.02435263
110MP0008995_early_reproductive_senescence1.02433344
111MP0008775_abnormal_heart_ventricle1.01833741
112MP0002088_abnormal_embryonic_growth/wei1.00739723
113MP0005084_abnormal_gallbladder_morpholo0.98723148
114MP0004043_abnormal_pH_regulation0.98435885
115MP0000358_abnormal_cell_content/0.98234644
116MP0005386_behavior/neurological_phenoty0.98139526
117MP0004924_abnormal_behavior0.98139526
118MP0006072_abnormal_retinal_apoptosis0.97371214
119MP0004142_abnormal_muscle_tone0.97364906
120MP0003879_abnormal_hair_cell0.96775571
121MP0003567_abnormal_fetal_cardiomyocyte0.96581306
122MP0009333_abnormal_splenocyte_physiolog0.96517279
123MP0000955_abnormal_spinal_cord0.96251924
124MP0002085_abnormal_embryonic_tissue0.95514658
125MP0002019_abnormal_tumor_incidence0.94916345
126MP0000490_abnormal_crypts_of0.94031694
127MP0006276_abnormal_autonomic_nervous0.93195039
128MP0004215_abnormal_myocardial_fiber0.93167797
129MP0001293_anophthalmia0.92791530
130MP0002882_abnormal_neuron_morphology0.90648264
131MP0003763_abnormal_thymus_physiology0.90165390
132MP0002229_neurodegeneration0.88620869
133MP0005451_abnormal_body_composition0.87746005
134MP0001764_abnormal_homeostasis0.86013892
135MP0003938_abnormal_ear_development0.86012690
136MP0010386_abnormal_urinary_bladder0.85083606
137MP0002095_abnormal_skin_pigmentation0.84103115
138MP0000566_synostosis0.82648151
139MP0002938_white_spotting0.81647242
140MP0004808_abnormal_hematopoietic_stem0.79778505
141MP0002161_abnormal_fertility/fecundity0.79009804
142MP0009672_abnormal_birth_weight0.78867725
143MP0005384_cellular_phenotype0.75556573
144MP0001727_abnormal_embryo_implantation0.74279990
145MP0002751_abnormal_autonomic_nervous0.74223979
146MP0002084_abnormal_developmental_patter0.74187588
147MP0003699_abnormal_female_reproductive0.68514983
148MP0005266_abnormal_metabolism0.68463552
149MP0000703_abnormal_thymus_morphology0.67993683
150MP0001919_abnormal_reproductive_system0.65675663
151MP0001545_abnormal_hematopoietic_system0.64589434
152MP0005397_hematopoietic_system_phenotyp0.64589434
153MP0005409_darkened_coat_color0.64036993
154MP0002876_abnormal_thyroid_physiology0.63931046
155MP0002086_abnormal_extraembryonic_tissu0.63072016
156MP0003119_abnormal_digestive_system0.62109303
157MP0003186_abnormal_redox_activity0.62003444
158MP0004197_abnormal_fetal_growth/weight/0.61650263
159MP0002837_dystrophic_cardiac_calcinosis0.61278792
160MP0002398_abnormal_bone_marrow0.60370732
161MP0005174_abnormal_tail_pigmentation0.59794021
162MP0010307_abnormal_tumor_latency0.59733791
163MP0005646_abnormal_pituitary_gland0.58578747
164MP0001286_abnormal_eye_development0.55660599
165MP0001186_pigmentation_phenotype0.55027249
166MP0000689_abnormal_spleen_morphology0.53796801

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.69945875
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.88062516
3Chromsome breakage (HP:0040012)3.86379449
4Molar tooth sign on MRI (HP:0002419)3.71910342
5Abnormality of midbrain morphology (HP:0002418)3.71910342
6Oral leukoplakia (HP:0002745)3.62975715
7Reticulocytopenia (HP:0001896)3.61693156
8Breast hypoplasia (HP:0003187)3.59973392
9Nephronophthisis (HP:0000090)3.57131427
10Aplastic anemia (HP:0001915)3.51834387
11Abnormality of the preputium (HP:0100587)3.48005829
12Cerebral hypomyelination (HP:0006808)3.41967008
13Acute necrotizing encephalopathy (HP:0006965)3.41955625
14Congenital stationary night blindness (HP:0007642)3.30213384
15Patellar aplasia (HP:0006443)3.11766527
16Type II lissencephaly (HP:0007260)3.08624775
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.08391352
18Hepatocellular necrosis (HP:0001404)3.07578344
19Meckel diverticulum (HP:0002245)3.07506345
20Mitochondrial inheritance (HP:0001427)3.07240649
21Abnormality of chromosome stability (HP:0003220)3.07223114
223-Methylglutaconic aciduria (HP:0003535)3.04694273
23Abnormality of the renal medulla (HP:0100957)3.02576025
24Increased CSF lactate (HP:0002490)3.02485820
25Abnormal mitochondria in muscle tissue (HP:0008316)3.02028374
26Abnormality of the ileum (HP:0001549)2.96679373
27Hyperventilation (HP:0002883)2.96087777
28Abnormality of the renal cortex (HP:0011035)2.94624733
29Aplasia/Hypoplasia of the patella (HP:0006498)2.88844716
30Abnormality of cells of the erythroid lineage (HP:0012130)2.82774995
31Progressive macrocephaly (HP:0004481)2.79955386
32Rough bone trabeculation (HP:0100670)2.77608346
33Absent thumb (HP:0009777)2.76568520
34Abnormal number of erythroid precursors (HP:0012131)2.75163574
35Abnormality of the labia minora (HP:0012880)2.74458452
36Increased hepatocellular lipid droplets (HP:0006565)2.63439843
37Acute encephalopathy (HP:0006846)2.62153942
38Hepatic necrosis (HP:0002605)2.62016407
39Progressive cerebellar ataxia (HP:0002073)2.60720895
40Increased serum pyruvate (HP:0003542)2.60116655
41Abnormality of glycolysis (HP:0004366)2.60116655
42Increased serum lactate (HP:0002151)2.59101349
43Cystic liver disease (HP:0006706)2.57916741
44Pendular nystagmus (HP:0012043)2.56888370
45Pancreatic fibrosis (HP:0100732)2.49890124
46Genetic anticipation (HP:0003743)2.49797081
47Bone marrow hypocellularity (HP:0005528)2.47311904
48Abolished electroretinogram (ERG) (HP:0000550)2.47301008
49Type 2 muscle fiber atrophy (HP:0003554)2.44093327
50Abnormal spermatogenesis (HP:0008669)2.42742715
51Microvesicular hepatic steatosis (HP:0001414)2.42683638
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42505830
53Myelodysplasia (HP:0002863)2.42121580
54Sclerocornea (HP:0000647)2.40689370
55Chronic hepatic failure (HP:0100626)2.39144499
56Premature graying of hair (HP:0002216)2.36067864
57Renal cortical cysts (HP:0000803)2.34602717
58Impulsivity (HP:0100710)2.34417335
59Colon cancer (HP:0003003)2.34311917
60Abnormality of the anterior horn cell (HP:0006802)2.33968693
61Degeneration of anterior horn cells (HP:0002398)2.33968693
62Horseshoe kidney (HP:0000085)2.33453556
63Lipid accumulation in hepatocytes (HP:0006561)2.32499489
64Tubular atrophy (HP:0000092)2.31452657
65Medulloblastoma (HP:0002885)2.30320126
66Abnormality of DNA repair (HP:0003254)2.28686278
67Duplicated collecting system (HP:0000081)2.26766512
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26587445
69Abnormal rod and cone electroretinograms (HP:0008323)2.26127235
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23782346
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23782346
72Gaze-evoked nystagmus (HP:0000640)2.23618935
73Carpal bone hypoplasia (HP:0001498)2.22003827
74Pancytopenia (HP:0001876)2.21990818
75Attenuation of retinal blood vessels (HP:0007843)2.21327948
76Cerebellar dysplasia (HP:0007033)2.20165694
77Congenital, generalized hypertrichosis (HP:0004540)2.20160921
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.20144121
79Pallor (HP:0000980)2.19376464
80Cellular immunodeficiency (HP:0005374)2.19270478
81Absent radius (HP:0003974)2.19218101
82Abnormal drinking behavior (HP:0030082)2.19139059
83Polydipsia (HP:0001959)2.19139059
84Broad-based gait (HP:0002136)2.17431474
85Small intestinal stenosis (HP:0012848)2.17315797
86Duodenal stenosis (HP:0100867)2.17315797
87Anencephaly (HP:0002323)2.17098252
88Macrocytic anemia (HP:0001972)2.15484467
89Triphalangeal thumb (HP:0001199)2.14545136
90Exercise intolerance (HP:0003546)2.13933570
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13115067
92Genital tract atresia (HP:0001827)2.12994723
93Lactic acidosis (HP:0003128)2.12970223
94Muscle fiber atrophy (HP:0100295)2.12350654
95Protruding tongue (HP:0010808)2.12207972
96Methylmalonic acidemia (HP:0002912)2.11094818
97Bony spicule pigmentary retinopathy (HP:0007737)2.09069871
9811 pairs of ribs (HP:0000878)2.09021682
99Abnormal trabecular bone morphology (HP:0100671)2.07542962
100Aplasia involving forearm bones (HP:0009822)2.07342108
101Absent forearm bone (HP:0003953)2.07342108
102Decreased circulating renin level (HP:0003351)2.07216856
103Microretrognathia (HP:0000308)2.07151439
104Short tibia (HP:0005736)2.06885550
105Postnatal microcephaly (HP:0005484)2.06617073
106CNS hypomyelination (HP:0003429)2.06143093
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.05176083
108Absent/shortened dynein arms (HP:0200106)2.04850123
109Dynein arm defect of respiratory motile cilia (HP:0012255)2.04850123
110Vaginal atresia (HP:0000148)2.04437707
111Respiratory difficulties (HP:0002880)2.03639267
112Hypoplasia of the pons (HP:0012110)2.03638911
113Abnormality of the renal collecting system (HP:0004742)2.01922753
114Ectopic kidney (HP:0000086)2.00959496
115Lissencephaly (HP:0001339)2.00230753
116Abnormality of alanine metabolism (HP:0010916)2.00016910
117Hyperalaninemia (HP:0003348)2.00016910
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00016910
119Aplasia/Hypoplasia of the sternum (HP:0006714)2.00005549
120Unsteady gait (HP:0002317)1.99765710
121Sloping forehead (HP:0000340)1.99738617
122Concave nail (HP:0001598)1.99378280
123Oligodactyly (hands) (HP:0001180)1.98894551
124Fibular aplasia (HP:0002990)1.98726485
125Male pseudohermaphroditism (HP:0000037)1.97666474
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97271991
127Decreased central vision (HP:0007663)1.96567345
128Type I transferrin isoform profile (HP:0003642)1.96545288
129True hermaphroditism (HP:0010459)1.96213089
130Renal Fanconi syndrome (HP:0001994)1.95811025
131Furrowed tongue (HP:0000221)1.94263894
132Pancreatic cysts (HP:0001737)1.93698261
133Abnormality of the pons (HP:0007361)1.93499337
134Exertional dyspnea (HP:0002875)1.92984862
135Agitation (HP:0000713)1.92504115
136Poor coordination (HP:0002370)1.92311123
137Postaxial foot polydactyly (HP:0001830)1.90986146
138Pachygyria (HP:0001302)1.90191978
139Medial flaring of the eyebrow (HP:0010747)1.89648035
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.88012121
141Congenital hepatic fibrosis (HP:0002612)1.87877506
142Hyperglycinemia (HP:0002154)1.87537958
143Facial cleft (HP:0002006)1.85308139
144Secondary amenorrhea (HP:0000869)1.85234996
145Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85075380
146Optic nerve hypoplasia (HP:0000609)1.85022537
147Inability to walk (HP:0002540)1.84893826
148Nephrogenic diabetes insipidus (HP:0009806)1.84541767
149Clubbing of toes (HP:0100760)1.84087736
150Asplenia (HP:0001746)1.83489962
151Congenital primary aphakia (HP:0007707)1.82878316
152Gait imbalance (HP:0002141)1.82374127
153Febrile seizures (HP:0002373)1.80428595
154Severe visual impairment (HP:0001141)1.79696831
155Respiratory failure (HP:0002878)1.79250580
156Methylmalonic aciduria (HP:0012120)1.77970590
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77202362
158Tachypnea (HP:0002789)1.77011827
159Pulmonary fibrosis (HP:0002206)1.76149612
160Small hand (HP:0200055)1.73853711
161Abnormal respiratory motile cilium morphology (HP:0005938)1.72934102
162Abnormal respiratory epithelium morphology (HP:0012253)1.72934102
163Abnormal ciliary motility (HP:0012262)1.72829118
164Optic disc pallor (HP:0000543)1.72780680
165Septo-optic dysplasia (HP:0100842)1.71410119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.21876858
2STK163.79480376
3WEE13.63676069
4CDC73.43588456
5ACVR1B3.23161828
6BUB13.18246330
7TSSK63.16156528
8SRPK13.01371628
9VRK12.76227574
10CASK2.58560776
11PLK42.57249877
12TAOK32.54837046
13EIF2AK12.52659605
14NUAK12.40205524
15GRK12.39688137
16WNK42.29582179
17INSRR2.18020362
18WNK32.13418300
19MAP4K22.12941935
20NME12.01939460
21BRAF2.01097794
22PLK31.99552516
23BRSK21.87426048
24EIF2AK31.82283070
25MKNK11.72256357
26MKNK21.63578789
27PLK11.62940939
28AKT31.60606253
29TTK1.59610425
30CCNB11.55167311
31MAP2K71.54865817
32BMPR1B1.54117046
33NTRK31.49448254
34SIK31.46231994
35ARAF1.43980565
36CDK81.42532727
37PNCK1.39696263
38STK391.39571497
39CHEK21.39410510
40TNIK1.39115050
41ATR1.37363570
42DYRK31.33773025
43OXSR11.31150953
44STK38L1.30780315
45ZAK1.25714336
46NTRK21.21641069
47BRSK11.19770964
48PRKCG1.18692895
49STK241.18517676
50CDK71.18470227
51NME21.18167501
52BRD41.17657710
53PHKG21.15996604
54PHKG11.15996604
55PIM21.15057644
56NEK21.12143426
57MAP3K61.10253822
58CAMKK21.07701562
59TAF11.06806626
60AURKA1.05451356
61PIK3CA1.03682583
62CHEK11.02816274
63NEK11.02639413
64DYRK21.02480030
65AURKB1.01496129
66PAK31.01248432
67TLK10.98813585
68ADRBK20.98799686
69CDK190.94272680
70MUSK0.92394830
71SIK20.92256473
72TGFBR10.91959224
73MAP3K40.91109985
74STK110.91025378
75ADRBK10.88183011
76DAPK20.85882196
77VRK20.84870344
78RAF10.81132504
79SGK20.79271293
80PASK0.78764979
81CSNK2A20.74280477
82CSNK2A10.73215738
83RPS6KB20.73108193
84PLK20.73041538
85PRKCE0.72969274
86FGFR20.72462765
87ATM0.72069717
88CSNK1G30.69266360
89CDK40.69175262
90CDK30.69005134
91SGK4940.68584120
92SGK2230.68584120
93MAPK130.68316032
94EPHA40.66999680
95TESK20.66044233
96TIE10.65543819
97PKN10.64030438
98PRKCI0.63838865
99TYRO30.62173637
100CAMK10.61825120
101CDK20.61539768
102CAMK2A0.61115465
103PRKACA0.58787674
104RPS6KA60.57476192
105MAPKAPK50.57088931
106SGK10.56340263
107CAMK1D0.55315171
108CAMK1G0.54658461
109EIF2AK20.54397073
110BMPR20.52982030
111CDK10.52684111
112PRKCZ0.51615236
113PRKCQ0.50852332
114BCR0.49275730
115TEC0.49075755
116MINK10.47668522
117CAMKK10.47351520
118CSNK1G10.47144896
119MAP3K90.46214924
120CSNK1A10.45607819
121NEK60.45355652
122IRAK30.45247846
123IKBKB0.44385320
124DAPK10.44286183
125PDK30.43634355
126PDK40.43634355
127WNK10.40266423
128MELK0.39824366
129CSNK1G20.39808724
130PRKG10.39413218
131MAP3K120.38061419
132CSNK1D0.38023373
133MAPK150.37855717
134PAK10.35302165
135PRKCA0.35157807
136MARK30.34924740
137YES10.34902893
138MAP2K40.34794973
139RPS6KA40.34759699
140CSNK1E0.34407629
141RPS6KA50.33536200
142TXK0.30469916
143MST40.26403750
144KSR10.25814617
145BLK0.25546164
146RPS6KB10.22092656
147LATS20.21926428
148PIM10.21138292
149PINK10.20620179
150ABL20.19897744
151MARK10.19306210
152ERBB30.19007380
153DYRK1A0.18817111
154MAP3K80.18212464
155MAPK40.18167343
156OBSCN0.16884784

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.35565778
2DNA replication_Homo sapiens_hsa030304.18846614
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06116649
4Proteasome_Homo sapiens_hsa030503.92671559
5Mismatch repair_Homo sapiens_hsa034303.82556764
6Ribosome_Homo sapiens_hsa030103.37566883
7Spliceosome_Homo sapiens_hsa030403.12934427
8Homologous recombination_Homo sapiens_hsa034403.03957159
9RNA transport_Homo sapiens_hsa030133.03017120
10Pyrimidine metabolism_Homo sapiens_hsa002402.90074023
11Nucleotide excision repair_Homo sapiens_hsa034202.82096540
12Caffeine metabolism_Homo sapiens_hsa002322.72267394
13Basal transcription factors_Homo sapiens_hsa030222.60393254
14Base excision repair_Homo sapiens_hsa034102.57850528
15Fanconi anemia pathway_Homo sapiens_hsa034602.52022320
16Cell cycle_Homo sapiens_hsa041102.29245135
17RNA degradation_Homo sapiens_hsa030182.20700140
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19444684
19Non-homologous end-joining_Homo sapiens_hsa034502.11077320
20Vitamin B6 metabolism_Homo sapiens_hsa007502.03360270
21Oxidative phosphorylation_Homo sapiens_hsa001901.93553382
22Protein export_Homo sapiens_hsa030601.91238672
23One carbon pool by folate_Homo sapiens_hsa006701.88297736
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82634810
25Purine metabolism_Homo sapiens_hsa002301.79022206
26Parkinsons disease_Homo sapiens_hsa050121.78625624
27Nitrogen metabolism_Homo sapiens_hsa009101.77511357
28Tryptophan metabolism_Homo sapiens_hsa003801.75008011
29Morphine addiction_Homo sapiens_hsa050321.68611866
30Huntingtons disease_Homo sapiens_hsa050161.63944267
31Butanoate metabolism_Homo sapiens_hsa006501.63845228
32mRNA surveillance pathway_Homo sapiens_hsa030151.56703996
33Olfactory transduction_Homo sapiens_hsa047401.52632502
34Glutamatergic synapse_Homo sapiens_hsa047241.34127459
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33099140
36Circadian entrainment_Homo sapiens_hsa047131.31580971
37Folate biosynthesis_Homo sapiens_hsa007901.31504670
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27596782
39GABAergic synapse_Homo sapiens_hsa047271.27202242
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23119737
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22732486
42Insulin secretion_Homo sapiens_hsa049111.18369152
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16513100
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13477245
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.08200323
46Epstein-Barr virus infection_Homo sapiens_hsa051691.05817527
47p53 signaling pathway_Homo sapiens_hsa041151.01073767
48Propanoate metabolism_Homo sapiens_hsa006401.00470181
49Alzheimers disease_Homo sapiens_hsa050100.99577471
50Chemical carcinogenesis_Homo sapiens_hsa052040.97443090
51Retinol metabolism_Homo sapiens_hsa008300.96680442
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94408642
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94174687
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.88512996
55Dopaminergic synapse_Homo sapiens_hsa047280.88074422
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87877513
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87468882
58Cocaine addiction_Homo sapiens_hsa050300.85981314
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85605308
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83879048
61Peroxisome_Homo sapiens_hsa041460.81770555
62Oocyte meiosis_Homo sapiens_hsa041140.80094486
63Calcium signaling pathway_Homo sapiens_hsa040200.77749782
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.75508916
65Cholinergic synapse_Homo sapiens_hsa047250.75425296
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74013886
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73980044
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.72165417
69Regulation of autophagy_Homo sapiens_hsa041400.70995594
70Ovarian steroidogenesis_Homo sapiens_hsa049130.70452636
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.68800897
72beta-Alanine metabolism_Homo sapiens_hsa004100.66668463
73Glycerolipid metabolism_Homo sapiens_hsa005610.64817152
74Amphetamine addiction_Homo sapiens_hsa050310.63959355
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62300747
76Long-term depression_Homo sapiens_hsa047300.58808294
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58131172
78Salivary secretion_Homo sapiens_hsa049700.57517823
79Metabolic pathways_Homo sapiens_hsa011000.57318794
80Biosynthesis of amino acids_Homo sapiens_hsa012300.57139908
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53662156
82Type II diabetes mellitus_Homo sapiens_hsa049300.53023677
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50889137
84Pentose phosphate pathway_Homo sapiens_hsa000300.50349514
85Selenocompound metabolism_Homo sapiens_hsa004500.50161853
86Oxytocin signaling pathway_Homo sapiens_hsa049210.49103281
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46220845
88cAMP signaling pathway_Homo sapiens_hsa040240.45933425
89Sulfur relay system_Homo sapiens_hsa041220.45581719
90Axon guidance_Homo sapiens_hsa043600.44873891
91Renin secretion_Homo sapiens_hsa049240.44566277
92Herpes simplex infection_Homo sapiens_hsa051680.44228665
93ABC transporters_Homo sapiens_hsa020100.44102819
94Vitamin digestion and absorption_Homo sapiens_hsa049770.40588308
95Asthma_Homo sapiens_hsa053100.40356766
96Hedgehog signaling pathway_Homo sapiens_hsa043400.39362872
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38141511
98Cardiac muscle contraction_Homo sapiens_hsa042600.37684670
99Dorso-ventral axis formation_Homo sapiens_hsa043200.36864485
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36673298
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36526350
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36022435
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35573393
104Basal cell carcinoma_Homo sapiens_hsa052170.34338904
105Systemic lupus erythematosus_Homo sapiens_hsa053220.33809323
106Nicotine addiction_Homo sapiens_hsa050330.33235356
107Fat digestion and absorption_Homo sapiens_hsa049750.32732958
108Gastric acid secretion_Homo sapiens_hsa049710.31741844
109Pyruvate metabolism_Homo sapiens_hsa006200.31438522
110Carbon metabolism_Homo sapiens_hsa012000.31248394
111Collecting duct acid secretion_Homo sapiens_hsa049660.30984076
112Phototransduction_Homo sapiens_hsa047440.29405218
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28580554
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28245538
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27665139
116N-Glycan biosynthesis_Homo sapiens_hsa005100.26183015
117Glutathione metabolism_Homo sapiens_hsa004800.24369084
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23317974
119Thyroid cancer_Homo sapiens_hsa052160.23051372
120Antigen processing and presentation_Homo sapiens_hsa046120.22757274
121Primary immunodeficiency_Homo sapiens_hsa053400.21773548
122Viral carcinogenesis_Homo sapiens_hsa052030.21772557
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20353258
124Linoleic acid metabolism_Homo sapiens_hsa005910.18599434
125Vibrio cholerae infection_Homo sapiens_hsa051100.18023336
126Arachidonic acid metabolism_Homo sapiens_hsa005900.16282631
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15917577
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14241765
129Circadian rhythm_Homo sapiens_hsa047100.14010627
130Alcoholism_Homo sapiens_hsa050340.13564790
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12859935
132HTLV-I infection_Homo sapiens_hsa051660.11921847
133Colorectal cancer_Homo sapiens_hsa052100.11869847
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11163066
135Ether lipid metabolism_Homo sapiens_hsa005650.11089948
136Fructose and mannose metabolism_Homo sapiens_hsa000510.11012661
137Arginine and proline metabolism_Homo sapiens_hsa003300.09998229
138Fatty acid elongation_Homo sapiens_hsa000620.09268325
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.07036514
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.05090448
141Taste transduction_Homo sapiens_hsa047420.04953717
142Other glycan degradation_Homo sapiens_hsa005110.04752097
143Synaptic vesicle cycle_Homo sapiens_hsa047210.04604125
144Tyrosine metabolism_Homo sapiens_hsa003500.04331496
145Type I diabetes mellitus_Homo sapiens_hsa049400.01518647
146Allograft rejection_Homo sapiens_hsa053300.00354460
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00262586
148Serotonergic synapse_Homo sapiens_hsa04726-0.0357572
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0336363
150alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0255021
151Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0062650
152Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0033374

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