ZC3HAV1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)4.66244762
2regulation of stem cell maintenance (GO:2000036)4.38067659
3negative regulation of thymocyte apoptotic process (GO:0070244)4.29432811
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23025392
5lateral sprouting from an epithelium (GO:0060601)4.19414715
6platelet dense granule organization (GO:0060155)4.10874013
7mannosylation (GO:0097502)3.81933988
8mitotic sister chromatid cohesion (GO:0007064)3.76715561
9pre-miRNA processing (GO:0031054)3.75184184
10protein K11-linked deubiquitination (GO:0035871)3.65734368
11positive regulation of endothelial cell differentiation (GO:0045603)3.62710986
12response to pheromone (GO:0019236)3.60448445
13kinetochore organization (GO:0051383)3.56275933
14DNA unwinding involved in DNA replication (GO:0006268)3.51037214
15head development (GO:0060322)3.45371338
16paraxial mesoderm development (GO:0048339)3.43935133
17preassembly of GPI anchor in ER membrane (GO:0016254)3.43801819
18prenylation (GO:0097354)3.42348626
19protein prenylation (GO:0018342)3.42348626
20meiotic chromosome segregation (GO:0045132)3.40179420
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38536008
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37828635
23regulation of glucokinase activity (GO:0033131)3.36381801
24regulation of hexokinase activity (GO:1903299)3.36381801
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32694800
26negative regulation of RNA splicing (GO:0033119)3.32007428
27kinetochore assembly (GO:0051382)3.30262481
28mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.28783520
29DNA deamination (GO:0045006)3.28304631
30nuclear pore complex assembly (GO:0051292)3.25311216
31transcription from mitochondrial promoter (GO:0006390)3.22696100
32detection of light stimulus involved in sensory perception (GO:0050962)3.21770704
33detection of light stimulus involved in visual perception (GO:0050908)3.21770704
34regulation of hippo signaling (GO:0035330)3.17342343
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.14685825
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.13504673
37regulation of endothelial cell differentiation (GO:0045601)3.08557065
38nuclear pore organization (GO:0006999)3.07423356
39viral transcription (GO:0019083)3.05972919
40negative regulation of mRNA processing (GO:0050686)3.04619696
41regulation of integrin activation (GO:0033623)3.01964685
42regulation of non-canonical Wnt signaling pathway (GO:2000050)2.98490736
43replicative senescence (GO:0090399)2.97891592
44indolalkylamine metabolic process (GO:0006586)2.96007336
45positive regulation of granulocyte differentiation (GO:0030854)2.95279655
46proximal/distal pattern formation (GO:0009954)2.95243288
47cardiolipin metabolic process (GO:0032048)2.94970784
48translational termination (GO:0006415)2.92303840
49replication fork processing (GO:0031297)2.91556045
50anterior/posterior axis specification, embryo (GO:0008595)2.90749875
51positive regulation of developmental pigmentation (GO:0048087)2.90020217
52DNA topological change (GO:0006265)2.89905943
53monoubiquitinated protein deubiquitination (GO:0035520)2.87318005
54telomere maintenance via semi-conservative replication (GO:0032201)2.87267906
55regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87213320
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85593143
57polyketide metabolic process (GO:0030638)2.84483569
58doxorubicin metabolic process (GO:0044598)2.84483569
59daunorubicin metabolic process (GO:0044597)2.84483569
60ribosomal small subunit biogenesis (GO:0042274)2.84090788
61fucose catabolic process (GO:0019317)2.82918774
62L-fucose metabolic process (GO:0042354)2.82918774
63L-fucose catabolic process (GO:0042355)2.82918774
64positive regulation of protein homodimerization activity (GO:0090073)2.82569830
65cell proliferation involved in metanephros development (GO:0072203)2.82311626
66reciprocal meiotic recombination (GO:0007131)2.82137923
67reciprocal DNA recombination (GO:0035825)2.82137923
68double-strand break repair via homologous recombination (GO:0000724)2.82072439
69ribosomal small subunit assembly (GO:0000028)2.82016063
70sister chromatid segregation (GO:0000819)2.80719084
71establishment of tissue polarity (GO:0007164)2.80536968
72establishment of planar polarity (GO:0001736)2.80536968
73tryptophan metabolic process (GO:0006568)2.80352618
74dopamine transport (GO:0015872)2.80191892
75regulation of histone H3-K27 methylation (GO:0061085)2.78727547
76generation of neurons (GO:0048699)2.77104997
77regulation of establishment of planar polarity (GO:0090175)2.76506005
78fibroblast migration (GO:0010761)2.75248251
79regulation of DNA endoreduplication (GO:0032875)2.74511942
80negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73720250
81protein localization to kinetochore (GO:0034501)2.73611035
82hippo signaling (GO:0035329)2.72854819
83recombinational repair (GO:0000725)2.72705674
84DNA strand elongation involved in DNA replication (GO:0006271)2.71932963
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70234837
86microtubule depolymerization (GO:0007019)2.68585674
87regulation of RNA export from nucleus (GO:0046831)2.68447436
88hindlimb morphogenesis (GO:0035137)2.67938507
89regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67471217
90peptidyl-histidine modification (GO:0018202)2.66844662
91embryonic hindlimb morphogenesis (GO:0035116)2.66677947
92nucleosome disassembly (GO:0006337)2.66549019
93protein-DNA complex disassembly (GO:0032986)2.66549019
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66112746
95behavioral response to nicotine (GO:0035095)2.66026081
96regulation of sister chromatid cohesion (GO:0007063)2.65935799
97sphingoid metabolic process (GO:0046519)2.65263045
98DNA strand elongation (GO:0022616)2.65145160
99mitotic recombination (GO:0006312)2.64957798
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64433320
101pseudouridine synthesis (GO:0001522)2.63797162
102embryonic skeletal joint morphogenesis (GO:0060272)2.63421226
103middle ear morphogenesis (GO:0042474)2.62244846
104positive regulation of glycolytic process (GO:0045821)2.59017246
105RNA stabilization (GO:0043489)2.58999532
106mRNA stabilization (GO:0048255)2.58999532
107urogenital system development (GO:0001655)2.58663570
108dorsal/ventral axis specification (GO:0009950)2.58408589
109embryonic cranial skeleton morphogenesis (GO:0048701)2.58350485
110rhodopsin mediated signaling pathway (GO:0016056)2.58052988
111DNA double-strand break processing (GO:0000729)2.57938529
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56633843
113neural tube formation (GO:0001841)2.55978788
114GPI anchor metabolic process (GO:0006505)2.55888031
115adenosine metabolic process (GO:0046085)2.55471368
116negative regulation of mRNA metabolic process (GO:1903312)2.55430350
117notochord development (GO:0030903)2.54681507
118positive regulation of macrophage differentiation (GO:0045651)2.53185608
119negative regulation of DNA repair (GO:0045738)2.52852327
120bone trabecula formation (GO:0060346)2.52435225
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.52324666
122regulation of transmission of nerve impulse (GO:0051969)2.51620326
123interkinetic nuclear migration (GO:0022027)2.51155673
124convergent extension (GO:0060026)2.50700594
125negative regulation of chondrocyte differentiation (GO:0032331)2.50460112
126mesenchymal cell proliferation (GO:0010463)2.50435948
127cornea development in camera-type eye (GO:0061303)2.50420354
128telomere maintenance via recombination (GO:0000722)2.50295643
129protein complex biogenesis (GO:0070271)2.49377455
130eyelid development in camera-type eye (GO:0061029)2.49217569
131respiratory chain complex IV assembly (GO:0008535)2.48115224
132somite development (GO:0061053)2.47443374
133regulation of double-strand break repair (GO:2000779)2.47185284
134definitive hemopoiesis (GO:0060216)2.47127081
135polarized epithelial cell differentiation (GO:0030859)2.47100256
136dosage compensation (GO:0007549)2.47014443
137UDP-N-acetylglucosamine metabolic process (GO:0006047)2.46811678
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.46736530
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.46736530
140isotype switching (GO:0045190)2.46736530
141termination of RNA polymerase II transcription (GO:0006369)2.46434535
142mitochondrial RNA metabolic process (GO:0000959)2.46298023
143radial glial cell differentiation (GO:0060019)2.46253733
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.44900282
145NADH dehydrogenase complex assembly (GO:0010257)2.44900282
146mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44900282
147intra-S DNA damage checkpoint (GO:0031573)2.44680981
148angiogenesis involved in wound healing (GO:0060055)2.44587038
149mitotic nuclear envelope disassembly (GO:0007077)2.44246655
150mitochondrial respiratory chain complex assembly (GO:0033108)2.43714680
151cochlea morphogenesis (GO:0090103)2.43475570
152mitotic sister chromatid segregation (GO:0000070)2.42715168
153regulation of heart morphogenesis (GO:2000826)2.42048209
154regulation of integrin-mediated signaling pathway (GO:2001044)2.42007544
155non-canonical Wnt signaling pathway (GO:0035567)2.41754837
156DNA replication initiation (GO:0006270)2.41465823
157multicellular organism reproduction (GO:0032504)2.41243252
158regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.41129951
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.40218896
160C-terminal protein lipidation (GO:0006501)2.40013818
161regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.39985986
162RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.39730675
163mRNA splicing, via spliceosome (GO:0000398)2.39730675
164post-anal tail morphogenesis (GO:0036342)2.38283101
165cellular ketone body metabolic process (GO:0046950)2.38129838
166negative regulation of calcium ion transport into cytosol (GO:0010523)2.38120068
167RNA splicing, via transesterification reactions (GO:0000375)2.38085216
168mesenchymal to epithelial transition (GO:0060231)2.37115825
169epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.36775538
170embryonic skeletal system morphogenesis (GO:0048704)2.36762647
171DNA ligation (GO:0006266)2.36022276
172pore complex assembly (GO:0046931)2.35926811
173outer ear morphogenesis (GO:0042473)2.35679288
174body morphogenesis (GO:0010171)2.35499436
175positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.35122046
176positive regulation of cell cycle G2/M phase transition (GO:1902751)2.35122046
177maturation of SSU-rRNA (GO:0030490)2.34600026
178embryonic epithelial tube formation (GO:0001838)2.34502733
179sphingosine metabolic process (GO:0006670)2.34369348
180ether lipid metabolic process (GO:0046485)2.32802982
181protein K6-linked ubiquitination (GO:0085020)2.32364826
182methionine biosynthetic process (GO:0009086)2.30205475
183DNA demethylation (GO:0080111)2.30011448
184regulation of metalloenzyme activity (GO:0048552)2.29834025
185ketone body metabolic process (GO:1902224)2.28936207
186DNA dealkylation (GO:0035510)2.28231987
187regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.26270978
188maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.25867985
189positive regulation of steroid hormone secretion (GO:2000833)2.25828764
190GPI anchor biosynthetic process (GO:0006506)2.25222008
191purinergic nucleotide receptor signaling pathway (GO:0035590)2.25140034
192parturition (GO:0007567)2.25100354
193tyrosine metabolic process (GO:0006570)2.23430460
194aromatic amino acid family metabolic process (GO:0009072)2.23372313
195mast cell degranulation (GO:0043303)2.23339102
196mast cell activation involved in immune response (GO:0002279)2.23339102
197negative regulation of cell cycle arrest (GO:0071157)2.22768662
198DNA replication-dependent nucleosome organization (GO:0034723)2.22554460
199DNA replication-dependent nucleosome assembly (GO:0006335)2.22554460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11067638
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.81739503
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.65353361
4FOXM1_23109430_ChIP-Seq_U2OS_Human5.08626502
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55521569
6TP63_19390658_ChIP-ChIP_HaCaT_Human4.37050065
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.73885632
8ZNF274_21170338_ChIP-Seq_K562_Hela3.63607143
9* MYC_18555785_ChIP-Seq_MESCs_Mouse3.36169513
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19681018
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.68502685
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.62631634
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54890245
14IGF1R_20145208_ChIP-Seq_DFB_Human2.52856031
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43324774
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36745711
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33222870
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.31179154
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24804892
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.24621390
21GBX2_23144817_ChIP-Seq_PC3_Human2.22386628
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.08779761
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08028938
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01191772
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.97423814
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93904236
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89490917
28VDR_22108803_ChIP-Seq_LS180_Human1.86325022
29AR_21909140_ChIP-Seq_LNCAP_Human1.84971697
30GATA1_22025678_ChIP-Seq_K562_Human1.82714428
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81721379
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80830533
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80272626
34ER_23166858_ChIP-Seq_MCF-7_Human1.79963857
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78275436
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77268651
37MYC_22102868_ChIP-Seq_BL_Human1.76823620
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72713106
39SCL_19346495_ChIP-Seq_HPC-7_Human1.72184364
40SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.66262268
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.64643649
42TTF2_22483619_ChIP-Seq_HELA_Human1.64559143
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63911304
44* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.60743999
45P300_19829295_ChIP-Seq_ESCs_Human1.59189586
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59167587
47EWS_26573619_Chip-Seq_HEK293_Human1.55799298
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55362823
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55330026
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55015305
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54373904
52TAF15_26573619_Chip-Seq_HEK293_Human1.54236412
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54170783
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50808918
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50734018
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.50526331
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48911562
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48911562
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48911562
60STAT3_23295773_ChIP-Seq_U87_Human1.48615754
61* BRD4_25478319_ChIP-Seq_HGPS_Human1.46143744
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46003944
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45788264
64SMAD4_21799915_ChIP-Seq_A2780_Human1.42236064
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41902846
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41301418
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41119837
68XRN2_22483619_ChIP-Seq_HELA_Human1.38796996
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37715842
70CIITA_25753668_ChIP-Seq_RAJI_Human1.37281572
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36544407
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35733194
73* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35454943
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34347067
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34291611
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33826220
77VDR_23849224_ChIP-Seq_CD4+_Human1.33718607
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32241943
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32091147
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31348200
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.29692012
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.29539306
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.29487750
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29327290
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29124554
86CBP_20019798_ChIP-Seq_JUKART_Human1.29124554
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28965313
88FUS_26573619_Chip-Seq_HEK293_Human1.28345014
89TCF4_23295773_ChIP-Seq_U87_Human1.28130061
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27969959
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.27919983
92CJUN_26792858_Chip-Seq_BT549_Human1.27281786
93BCAT_22108803_ChIP-Seq_LS180_Human1.27232491
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26779989
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26201573
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25173105
97AR_25329375_ChIP-Seq_VCAP_Human1.25096697
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22726056
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22378128
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.22221402
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21914325
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21256773
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20921421
104* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19534661
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19130480
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.18326251
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.18311097
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17938213
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17715557
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.17647339
111CDX2_22108803_ChIP-Seq_LS180_Human1.17627764
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17444558
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17092687
114TP53_22573176_ChIP-Seq_HFKS_Human1.16598226
115IRF1_19129219_ChIP-ChIP_H3396_Human1.16166421
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.15653061
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.15104571
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.14704115
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14704115
120AR_21572438_ChIP-Seq_LNCaP_Human1.14267757
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13436314
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12185825
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11775605
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11530270
125ELK1_19687146_ChIP-ChIP_HELA_Human1.10612915
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09804254
127AR_20517297_ChIP-Seq_VCAP_Human1.09576307
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09338395
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.08920566
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08671243
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08570350
132RING1B_27294783_Chip-Seq_NPCs_Mouse1.08318699
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07631914
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07397571
135ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06869315
136TCF4_22108803_ChIP-Seq_LS180_Human1.06752620
137NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06438168
138GATA3_26560356_Chip-Seq_TH2_Human1.05876482
139ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05141047
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04701527
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04701527
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04200084
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03954804
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03846338
145GATA3_21878914_ChIP-Seq_MCF-7_Human1.03271510
146NANOG_19829295_ChIP-Seq_ESCs_Human1.02377582
147SOX2_19829295_ChIP-Seq_ESCs_Human1.02377582
148SMAD_19615063_ChIP-ChIP_OVARY_Human1.01941297
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01823976
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01284539
151ARNT_22903824_ChIP-Seq_MCF-7_Human1.01211628
152RNF2_27304074_Chip-Seq_NSC_Mouse1.00383328
153* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99820415
154FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99443813
155* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99403577
156GABP_17652178_ChIP-ChIP_JURKAT_Human0.97857277
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97557751
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97100691
159EZH2_27304074_Chip-Seq_ESCs_Mouse0.96929488
160NANOG_18555785_Chip-Seq_ESCs_Mouse0.96587943
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.96285950
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95223363
163NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94992800
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94588133
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94470437
166SRF_21415370_ChIP-Seq_HL-1_Mouse0.94065145
167MYC_18940864_ChIP-ChIP_HL60_Human0.94034924
168VDR_21846776_ChIP-Seq_THP-1_Human0.93988898
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92826795
170TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90534656
171ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90533038
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90519837
173MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89573325
174EZH2_22144423_ChIP-Seq_EOC_Human0.89216565
175CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87157961
176NANOG_16153702_ChIP-ChIP_HESCs_Human0.87019551
177CHD1_26751641_Chip-Seq_LNCaP_Human0.85957338
178POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84074622
179ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84069498
180SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83036546
181ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82603383
182ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82364404
183TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82243715
184* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79543906
185NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78412078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.98236418
2MP0010030_abnormal_orbit_morphology3.44241961
3MP0000569_abnormal_digit_pigmentation3.39975913
4MP0003121_genomic_imprinting2.98116213
5MP0009053_abnormal_anal_canal2.96416639
6MP0003950_abnormal_plasma_membrane2.90812741
7MP0000372_irregular_coat_pigmentation2.88996843
8MP0005464_abnormal_platelet_physiology2.87006087
9MP0009697_abnormal_copulation2.83415562
10MP0003123_paternal_imprinting2.80067909
11MP0000383_abnormal_hair_follicle2.75821128
12MP0000566_synostosis2.69041118
13MP0000537_abnormal_urethra_morphology2.66964881
14MP0002938_white_spotting2.60806276
15MP0002166_altered_tumor_susceptibility2.60433566
16MP0000049_abnormal_middle_ear2.50974769
17MP0010678_abnormal_skin_adnexa2.35213608
18MP0003385_abnormal_body_wall2.33564360
19MP0003718_maternal_effect2.26762358
20MP0005645_abnormal_hypothalamus_physiol2.25695861
21MP0002249_abnormal_larynx_morphology2.21541477
22MP0002006_tumorigenesis2.19029531
23MP0008438_abnormal_cutaneous_collagen2.11905465
24MP0002876_abnormal_thyroid_physiology2.10585016
25MP0003937_abnormal_limbs/digits/tail_de2.07941283
26MP0009250_abnormal_appendicular_skeleto2.06465172
27MP0008057_abnormal_DNA_replication2.02141226
28MP0006292_abnormal_olfactory_placode1.94235136
29MP0010094_abnormal_chromosome_stability1.92782218
30MP0005171_absent_coat_pigmentation1.92638545
31MP0003567_abnormal_fetal_cardiomyocyte1.89724672
32MP0008775_abnormal_heart_ventricle1.86703554
33MP0001293_anophthalmia1.85110198
34MP0005551_abnormal_eye_electrophysiolog1.82711942
35MP0003943_abnormal_hepatobiliary_system1.82441780
36MP0002282_abnormal_trachea_morphology1.79452766
37MP0000427_abnormal_hair_cycle1.77911574
38MP0003119_abnormal_digestive_system1.77740667
39MP0005075_abnormal_melanosome_morpholog1.76500558
40MP0003942_abnormal_urinary_system1.74922930
41MP0001879_abnormal_lymphatic_vessel1.74877103
42MP0008872_abnormal_physiological_respon1.74192459
43MP0004084_abnormal_cardiac_muscle1.72912997
44MP0003935_abnormal_craniofacial_develop1.72699631
45MP0003755_abnormal_palate_morphology1.69872969
46MP0004957_abnormal_blastocyst_morpholog1.67607703
47MP0000428_abnormal_craniofacial_morphol1.65863342
48MP0002932_abnormal_joint_morphology1.64163348
49MP0003693_abnormal_embryo_hatching1.62733612
50MP0005076_abnormal_cell_differentiation1.61058762
51MP0003890_abnormal_embryonic-extraembry1.60515631
52MP0001661_extended_life_span1.58234718
53MP0005220_abnormal_exocrine_pancreas1.57607353
54MP0005503_abnormal_tendon_morphology1.57098650
55MP0003941_abnormal_skin_development1.55745554
56MP0003938_abnormal_ear_development1.55679957
57MP0003077_abnormal_cell_cycle1.55619932
58MP0005248_abnormal_Harderian_gland1.53423780
59MP0005084_abnormal_gallbladder_morpholo1.52830590
60MP0002116_abnormal_craniofacial_bone1.52181417
61MP0008875_abnormal_xenobiotic_pharmacok1.51696754
62MP0000015_abnormal_ear_pigmentation1.51670556
63MP0006072_abnormal_retinal_apoptosis1.50273060
64MP0005083_abnormal_biliary_tract1.47685722
65MP0005408_hypopigmentation1.46515219
66MP0003111_abnormal_nucleus_morphology1.46358742
67MP0008007_abnormal_cellular_replicative1.45977216
68MP0000432_abnormal_head_morphology1.45438702
69MP0002085_abnormal_embryonic_tissue1.43464339
70MP0003252_abnormal_bile_duct1.41176315
71MP0000762_abnormal_tongue_morphology1.40482683
72MP0005367_renal/urinary_system_phenotyp1.40307205
73MP0000516_abnormal_urinary_system1.40307205
74MP0004197_abnormal_fetal_growth/weight/1.40158632
75MP0005167_abnormal_blood-brain_barrier1.38894007
76MP0002084_abnormal_developmental_patter1.38528470
77MP0002163_abnormal_gland_morphology1.37203292
78MP0008932_abnormal_embryonic_tissue1.35090325
79MP0000013_abnormal_adipose_tissue1.33939988
80MP0008961_abnormal_basal_metabolism1.31639805
81MP0002233_abnormal_nose_morphology1.30415635
82MP0003195_calcinosis1.27283429
83MP0002109_abnormal_limb_morphology1.26892060
84MP0008789_abnormal_olfactory_epithelium1.26790000
85MP0003315_abnormal_perineum_morphology1.26716070
86MP0002177_abnormal_outer_ear1.26362337
87MP0000465_gastrointestinal_hemorrhage1.26339621
88MP0001286_abnormal_eye_development1.25901442
89MP0000647_abnormal_sebaceous_gland1.24257060
90MP0005389_reproductive_system_phenotype1.24251295
91MP0005253_abnormal_eye_physiology1.23960962
92MP0000639_abnormal_adrenal_gland1.22321739
93MP0002396_abnormal_hematopoietic_system1.20577075
94MP0000350_abnormal_cell_proliferation1.20091939
95MP0003115_abnormal_respiratory_system1.19117947
96MP0005395_other_phenotype1.18627288
97MP0009780_abnormal_chondrocyte_physiolo1.18457560
98MP0002114_abnormal_axial_skeleton1.15922358
99MP0010368_abnormal_lymphatic_system1.15556955
100MP0001697_abnormal_embryo_size1.14800080
101MP0004272_abnormal_basement_membrane1.14610875
102MP0000534_abnormal_ureter_morphology1.14425550
103MP0001672_abnormal_embryogenesis/_devel1.14250138
104MP0005380_embryogenesis_phenotype1.14250138
105MP0000371_diluted_coat_color1.14098543
106MP0005508_abnormal_skeleton_morphology1.13570395
107MP0009703_decreased_birth_body1.12062244
108MP0009379_abnormal_foot_pigmentation1.11643128
109MP0005646_abnormal_pituitary_gland1.11387255
110MP0005670_abnormal_white_adipose1.11258235
111MP0002092_abnormal_eye_morphology1.11175929
112MP0002160_abnormal_reproductive_system1.10444324
113MP0002088_abnormal_embryonic_growth/wei1.09144137
114MP0003984_embryonic_growth_retardation1.08541991
115MP0002009_preneoplasia1.08392795
116MP0002086_abnormal_extraembryonic_tissu1.07536842
117MP0002837_dystrophic_cardiac_calcinosis1.06328932
118MP0000678_abnormal_parathyroid_gland1.04895304
119MP0004381_abnormal_hair_follicle1.04637628
120MP0008058_abnormal_DNA_repair1.03322194
121MP0002111_abnormal_tail_morphology1.03259077
122MP0000163_abnormal_cartilage_morphology1.00828470
123MP0002751_abnormal_autonomic_nervous1.00647486
124MP0001270_distended_abdomen1.00132431
125MP0003861_abnormal_nervous_system1.00094325
126MP0000490_abnormal_crypts_of0.99785331
127MP0002102_abnormal_ear_morphology0.99614242
128MP0002697_abnormal_eye_size0.99464021
129MP0000733_abnormal_muscle_development0.99310811
130MP0005187_abnormal_penis_morphology0.99062302
131MP0001919_abnormal_reproductive_system0.98987041
132MP0000230_abnormal_systemic_arterial0.98956480
133MP0005275_abnormal_skin_tensile0.98073367
134MP0005174_abnormal_tail_pigmentation0.97738137
135MP0004134_abnormal_chest_morphology0.97036089
136MP0001340_abnormal_eyelid_morphology0.96830532
137MP0002095_abnormal_skin_pigmentation0.96814470
138MP0003283_abnormal_digestive_organ0.95984277
139MP0002075_abnormal_coat/hair_pigmentati0.95814890
140MP0006054_spinal_hemorrhage0.94746953
141MP0002925_abnormal_cardiovascular_devel0.94567016
142MP0004043_abnormal_pH_regulation0.94227029
143MP0003787_abnormal_imprinting0.92225859
144MP0010352_gastrointestinal_tract_polyps0.92164068
145MP0005394_taste/olfaction_phenotype0.90015653
146MP0005499_abnormal_olfactory_system0.90015653
147MP0001835_abnormal_antigen_presentation0.89102971
148MP0002234_abnormal_pharynx_morphology0.87690027
149MP0002113_abnormal_skeleton_development0.87363763
150MP0005379_endocrine/exocrine_gland_phen0.86803274
151MP0005409_darkened_coat_color0.86198425
152MP0004808_abnormal_hematopoietic_stem0.85970235
153MP0002081_perinatal_lethality0.85928208
154MP0001730_embryonic_growth_arrest0.85030930
155MP0009672_abnormal_birth_weight0.84861905
156MP0001346_abnormal_lacrimal_gland0.84299254
157MP0003786_premature_aging0.83932227
158MP0004264_abnormal_extraembryonic_tissu0.82862687
159MP0003136_yellow_coat_color0.82407950
160MP0004036_abnormal_muscle_relaxation0.81913565
161MP0002080_prenatal_lethality0.81488489
162MP0000538_abnormal_urinary_bladder0.79481456
163MP0001186_pigmentation_phenotype0.77989543
164MP0008877_abnormal_DNA_methylation0.77634017
165MP0002877_abnormal_melanocyte_morpholog0.77098119
166MP0001324_abnormal_eye_pigmentation0.75704102
167MP0002168_other_aberrant_phenotype0.72894243
168MP0005410_abnormal_fertilization0.72812395
169MP0005195_abnormal_posterior_eye0.72683180
170MP0000249_abnormal_blood_vessel0.67119560
171MP0000003_abnormal_adipose_tissue0.66978608
172MP0000358_abnormal_cell_content/0.66897016
173MP0010386_abnormal_urinary_bladder0.66767144
174MP0005310_abnormal_salivary_gland0.66696537
175MP0002128_abnormal_blood_circulation0.65606191
176MP0000767_abnormal_smooth_muscle0.64384471
177MP0010234_abnormal_vibrissa_follicle0.61915644
178MP0008004_abnormal_stomach_pH0.61856264

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.19757314
2Short 4th metacarpal (HP:0010044)5.19757314
3Increased mean platelet volume (HP:0011877)3.93763548
4Abnormality of the 4th metacarpal (HP:0010012)3.88812716
5B lymphocytopenia (HP:0010976)3.75985519
6Menorrhagia (HP:0000132)3.68001466
7Attenuation of retinal blood vessels (HP:0007843)3.64422897
8Abnormality of B cell number (HP:0010975)3.59910066
9Prolonged bleeding time (HP:0003010)3.31403561
10Abnormal platelet volume (HP:0011876)3.28222249
11Hypothermia (HP:0002045)3.23041448
12Midline defect of the nose (HP:0004122)3.20586683
13Type II lissencephaly (HP:0007260)3.09234995
14Hypoproteinemia (HP:0003075)3.07635324
15Thyroiditis (HP:0100646)3.03419012
16Abnormality of the parietal bone (HP:0002696)3.02367076
17Pancreatic cysts (HP:0001737)3.00669643
18Petechiae (HP:0000967)2.97837179
19Cerebellar dysplasia (HP:0007033)2.88166375
20Abnormality of the phalanges of the hallux (HP:0010057)2.86362555
21Renal duplication (HP:0000075)2.84282773
22Congenital stationary night blindness (HP:0007642)2.76715669
23Abnormal number of incisors (HP:0011064)2.71994837
24Broad toe (HP:0001837)2.67505349
25Short middle phalanx of the 5th finger (HP:0004220)2.65600112
26Ketoacidosis (HP:0001993)2.64214925
27Broad thumb (HP:0011304)2.59586529
28Microglossia (HP:0000171)2.57863968
29Abnormality of the renal cortex (HP:0011035)2.54831533
30Trigonocephaly (HP:0000243)2.54230424
31Fair hair (HP:0002286)2.50369360
32Atresia of the external auditory canal (HP:0000413)2.48170301
33Volvulus (HP:0002580)2.45039442
34Increased number of teeth (HP:0011069)2.43856084
35Pancreatic fibrosis (HP:0100732)2.42896667
36Keratoconus (HP:0000563)2.39650448
37Increased corneal curvature (HP:0100692)2.39650448
38Cutaneous finger syndactyly (HP:0010554)2.37776085
39Increased nuchal translucency (HP:0010880)2.35840580
40Gaze-evoked nystagmus (HP:0000640)2.35222594
41Spinal cord lesions (HP:0100561)2.34770420
42Syringomyelia (HP:0003396)2.34770420
43Severe combined immunodeficiency (HP:0004430)2.30271708
44Abnormality of midbrain morphology (HP:0002418)2.29847236
45Molar tooth sign on MRI (HP:0002419)2.29847236
46Chromsome breakage (HP:0040012)2.29543766
47Mesomelia (HP:0003027)2.29327800
48Long eyelashes (HP:0000527)2.29110568
49Short 5th finger (HP:0009237)2.28913261
50True hermaphroditism (HP:0010459)2.26792983
51Facial hemangioma (HP:0000329)2.26517911
52Hypoplasia of the pons (HP:0012110)2.26275939
53Abnormality of the nasal septum (HP:0000419)2.24293261
54Colon cancer (HP:0003003)2.24242863
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.24034399
56Lissencephaly (HP:0001339)2.23291107
57Abnormal lung lobation (HP:0002101)2.22959364
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22629164
59Panhypogammaglobulinemia (HP:0003139)2.22395289
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.22285324
61Nephronophthisis (HP:0000090)2.22075464
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.22058489
63Clubbing of toes (HP:0100760)2.20848816
64Supernumerary ribs (HP:0005815)2.19989952
65Broad hallux (HP:0010055)2.19831800
66Broad phalanges of the hand (HP:0009768)2.19607393
67Reticulocytopenia (HP:0001896)2.19400008
68Abnormality of the prostate (HP:0008775)2.17529748
69Prostate neoplasm (HP:0100787)2.16470168
70Tubular atrophy (HP:0000092)2.15979835
71Bilateral microphthalmos (HP:0007633)2.15591273
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15482717
73Abnormality of alanine metabolism (HP:0010916)2.15482717
74Hyperalaninemia (HP:0003348)2.15482717
75Abnormality of abdominal situs (HP:0011620)2.15305633
76Abdominal situs inversus (HP:0003363)2.15305633
77Abnormality of the phalanges of the 5th finger (HP:0004213)2.15244691
78Abnormality of the renal medulla (HP:0100957)2.15214393
79Epistaxis (HP:0000421)2.14893217
80Rib fusion (HP:0000902)2.14763014
81Albinism (HP:0001022)2.13246596
82Bony spicule pigmentary retinopathy (HP:0007737)2.13026374
83Selective tooth agenesis (HP:0001592)2.11032775
84Abnormality of the pons (HP:0007361)2.10076595
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.10068515
86Cutaneous syndactyly (HP:0012725)2.09995332
87Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09917646
88Broad finger (HP:0001500)2.09346158
89Ectopic kidney (HP:0000086)2.07408843
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.06948430
91Chronic hepatic failure (HP:0100626)2.06400457
92Supernumerary bones of the axial skeleton (HP:0009144)2.05890035
93Medulloblastoma (HP:0002885)2.05483741
94Nephroblastoma (Wilms tumor) (HP:0002667)2.04872541
95Pseudobulbar signs (HP:0002200)2.04000768
96Hyperventilation (HP:0002883)2.03862148
97Proximal placement of thumb (HP:0009623)2.03654729
98Short chin (HP:0000331)2.01744641
99Hepatoblastoma (HP:0002884)2.00512127
100Anophthalmia (HP:0000528)2.00144940
101Broad phalanx (HP:0006009)1.99221720
102Bifid tongue (HP:0010297)1.98716508
103Cutaneous melanoma (HP:0012056)1.98667052
104Deviation of the thumb (HP:0009603)1.98254953
105Gingival bleeding (HP:0000225)1.96570113
106Asymmetry of the thorax (HP:0001555)1.96544205
107IgG deficiency (HP:0004315)1.96086621
108Medial flaring of the eyebrow (HP:0010747)1.95873544
109Morphological abnormality of the middle ear (HP:0008609)1.95826379
110Occipital encephalocele (HP:0002085)1.95825510
111Embryonal renal neoplasm (HP:0011794)1.93965936
112Uterine leiomyosarcoma (HP:0002891)1.91824836
113Leiomyosarcoma (HP:0100243)1.91824836
114IgA deficiency (HP:0002720)1.91759082
115Coronal craniosynostosis (HP:0004440)1.91552314
116Prominent nose (HP:0000448)1.91376531
117Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90193224
118Hypoglycemic seizures (HP:0002173)1.89113615
119Hypoplasia of the uterus (HP:0000013)1.88716417
120Oligodactyly (HP:0012165)1.88315915
121Shallow orbits (HP:0000586)1.87362169
122Broad long bones (HP:0005622)1.87207880
123Partial agenesis of the corpus callosum (HP:0001338)1.87143171
124Eosinophilia (HP:0001880)1.86844796
125Diastasis recti (HP:0001540)1.86504576
126Dislocated radial head (HP:0003083)1.86163076
127Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84653494
128Short tibia (HP:0005736)1.84476922
129Meckel diverticulum (HP:0002245)1.84398590
130Abnormality of the radial head (HP:0003995)1.84169508
131Broad palm (HP:0001169)1.83595461
132Abnormality of the ileum (HP:0001549)1.82423631
133Hypoplasia of the thymus (HP:0000778)1.81769554
134Renal cortical cysts (HP:0000803)1.81459476
135Concave nail (HP:0001598)1.80805920
136Neoplasm of the adrenal cortex (HP:0100641)1.78430320
137Purpura (HP:0000979)1.77892858
138Missing ribs (HP:0000921)1.77768750
139Abnormal protein glycosylation (HP:0012346)1.76800469
140Abnormal glycosylation (HP:0012345)1.76800469
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76800469
142Abnormal protein N-linked glycosylation (HP:0012347)1.76800469
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.76406423
144Abnormality of the fingertips (HP:0001211)1.76164182
145Dyschromatopsia (HP:0007641)1.75109848
146Abnormality of macular pigmentation (HP:0008002)1.75033559
147Neoplasm of striated muscle (HP:0009728)1.74944245
148Generalized hypopigmentation of hair (HP:0011358)1.74436460
149Preaxial foot polydactyly (HP:0001841)1.74403381
150Portal hypertension (HP:0001409)1.74227918
151Short phalanx of the thumb (HP:0009660)1.74102659
152Tongue fasciculations (HP:0001308)1.73730441
153Glucose intolerance (HP:0000833)1.73310348
154Abnormality of the incisor (HP:0000676)1.72796846
155Decreased central vision (HP:0007663)1.72307249
156Birth length less than 3rd percentile (HP:0003561)1.72255310
157Aplasia/Hypoplasia of the patella (HP:0006498)1.72030210
158Abnormality of the labia minora (HP:0012880)1.71745165
159Renal hypoplasia (HP:0000089)1.71297617
160Patellar aplasia (HP:0006443)1.70979981
161Hypoplasia of the maxilla (HP:0000327)1.69962591
16211 pairs of ribs (HP:0000878)1.69565087
163Narrow palate (HP:0000189)1.69454639
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.69186516
165Hypoplasia of the fovea (HP:0007750)1.69186516
166Skin tags (HP:0010609)1.68944039
167Partial duplication of the phalanx of hand (HP:0009999)1.68796000
168Anteriorly placed anus (HP:0001545)1.68794599
169Abnormality of the nasolacrimal system (HP:0000614)1.68229338
170Malignant gastrointestinal tract tumors (HP:0006749)1.66965405
171Gastrointestinal carcinoma (HP:0002672)1.66965405
172Abnormality of the diencephalon (HP:0010662)1.66393875
173Duodenal stenosis (HP:0100867)1.66368509
174Small intestinal stenosis (HP:0012848)1.66368509
175Ketosis (HP:0001946)1.65323064
176Bulbous nose (HP:0000414)1.65087259
177Hypoglycemic coma (HP:0001325)1.64676662
178Absent eyebrow (HP:0002223)1.64470918
179Aplasia/hypoplasia of the humerus (HP:0006507)1.63921818
180Vitreoretinal degeneration (HP:0000655)1.63853485
181Tracheomalacia (HP:0002779)1.63061546
182Myelomeningocele (HP:0002475)1.63048400
183Short humerus (HP:0005792)1.63001309
184Abnormality of chromosome stability (HP:0003220)1.62938847
185Inability to walk (HP:0002540)1.60994824
186Abnormality of the pancreatic islet cells (HP:0006476)1.60821071
187Abnormality of endocrine pancreas physiology (HP:0012093)1.60821071
188Abnormality of the hepatic vasculature (HP:0006707)1.60543084
189Increased density of long bones (HP:0006392)1.60245351
190Astigmatism (HP:0000483)1.60006378
191Constricted visual fields (HP:0001133)1.58972673
192Long clavicles (HP:0000890)1.58397886
193Impaired platelet aggregation (HP:0003540)1.57624187
194Abnormal platelet function (HP:0011869)1.57624187
195Abnormality of lateral ventricle (HP:0030047)1.56725797
196Furrowed tongue (HP:0000221)1.56242930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.01148104
2ZAK3.94808648
3CDK123.25762074
4CDC73.14327156
5MKNK12.97591444
6CLK12.97068905
7EPHB22.92204385
8MST42.78534384
9LATS12.67798974
10BMPR1B2.66635708
11MKNK22.60497864
12MAP4K22.48823837
13SRPK12.32039548
14TSSK62.27192234
15WNK42.19531165
16TAOK32.19036150
17BRD42.09793337
18PRKD22.01985729
19EPHA31.89092643
20CDK71.86434852
21DDR21.81281279
22NEK21.79768698
23ADRBK21.77736010
24PIK3CG1.77476062
25WEE11.75563529
26STK391.71404214
27MAP3K101.68104298
28TGFBR11.67733224
29VRK11.64182104
30PTK2B1.62995355
31STK31.59594469
32EIF2AK11.58822192
33TRPM71.57189741
34STK381.56165771
35VRK21.56130138
36YES11.52672464
37ACVR1B1.52069660
38TAF11.51434385
39UHMK11.50551927
40KSR11.48177650
41BRSK21.47589620
42SIK31.45052597
43NEK91.44157411
44TTK1.41305825
45PDGFRA1.39032903
46BUB11.37029777
47TLK11.34865567
48PLK31.34571008
49ICK1.34106286
50KDR1.33892638
51ATR1.33313745
52CDK61.32030407
53CCNB11.28525968
54CDK81.28425986
55TEC1.25966072
56CHEK21.25934719
57GRK11.25128221
58CAMKK21.25125861
59NLK1.23655206
60FER1.22749510
61MAPKAPK31.21262418
62INSRR1.16811374
63ERBB31.16607719
64EIF2AK31.14374262
65CSNK1G11.13446988
66PIM11.13380923
67PLK11.11040474
68TIE11.09941295
69MAPK111.07857585
70PASK1.07290875
71DYRK31.07088239
72MET1.06942260
73MARK31.06905406
74PIM21.06801261
75ADRBK11.05530952
76RPS6KB21.04714404
77MAPKAPK51.02949000
78WNK31.02893366
79CDK41.00126712
80MAPK130.98440729
81BMPR20.97677093
82PIK3CA0.96114271
83CSF1R0.94635238
84ERBB20.94406505
85CHEK10.93619715
86RPS6KA50.91617499
87FGFR10.89322142
88MTOR0.88189919
89MYLK0.87659775
90AURKB0.86910332
91RPS6KA40.86409048
92ATM0.85975801
93CASK0.85822713
94HIPK20.84582768
95CSNK1G30.84443518
96TRIM280.84175458
97CSNK1A1L0.79473928
98CDK20.79238201
99CAMK1D0.77332277
100DYRK1B0.77039039
101SCYL20.75055555
102KIT0.74718186
103NUAK10.74187721
104LATS20.73981328
105MELK0.73438663
106CDK10.73175154
107PRKCE0.73004954
108PRKAA20.72438722
109EIF2AK20.71719533
110MAP3K70.70612600
111TGFBR20.69827567
112STK100.67855385
113AKT30.67850643
114MATK0.65618906
115PLK40.65397863
116DMPK0.60119548
117PAK40.59581294
118NEK10.59400843
119PRKCI0.58464008
120EEF2K0.57764383
121CAMK1G0.57440479
122STK38L0.57425301
123BCR0.55168335
124STK40.54147673
125TNIK0.54099257
126OXSR10.53301047
127CDK90.52108639
128BCKDK0.51811033
129MAP3K120.51467409
130AKT10.50253078
131PAK20.50225395
132SIK10.49674473
133PLK20.49477102
134DAPK30.48852948
135IKBKB0.48481595
136STK110.48315671
137IRAK20.46719563
138MAPK140.45869113
139IRAK40.45626522
140ALK0.45102247
141AKT20.44349362
142SYK0.44346843
143CSNK2A10.43829498
144ERBB40.43643084
145GRK50.43475185
146WNK10.43371112
147DYRK20.42994672
148TNK20.41880554
149PRKAA10.41834778
150FLT30.40889874
151PDGFRB0.40745389
152FGFR20.39988249
153STK240.39064480
154MAPK10.38674092
155CAMK40.38306180
156CSNK2A20.38053649
157RPS6KL10.38041998
158RPS6KC10.38041998
159BMX0.37253432
160MAP3K130.35742193
161MAP2K10.35418226
162DAPK20.34898409
163MST1R0.33305751

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.58388228
2Basal cell carcinoma_Homo sapiens_hsa052173.31439307
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.11132976
4Spliceosome_Homo sapiens_hsa030403.04033314
5Mismatch repair_Homo sapiens_hsa034303.01548928
6Cell cycle_Homo sapiens_hsa041102.63484206
7Ribosome_Homo sapiens_hsa030102.60795842
8Base excision repair_Homo sapiens_hsa034102.51595942
9Nitrogen metabolism_Homo sapiens_hsa009102.51019470
10Phototransduction_Homo sapiens_hsa047442.49516737
11Asthma_Homo sapiens_hsa053102.48287277
12Homologous recombination_Homo sapiens_hsa034402.45269193
13Hedgehog signaling pathway_Homo sapiens_hsa043402.33077850
14RNA transport_Homo sapiens_hsa030132.12382445
15mRNA surveillance pathway_Homo sapiens_hsa030152.02860293
16Hippo signaling pathway_Homo sapiens_hsa043902.01116237
17Fanconi anemia pathway_Homo sapiens_hsa034601.99581618
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95536887
19Nucleotide excision repair_Homo sapiens_hsa034201.95172624
20Wnt signaling pathway_Homo sapiens_hsa043101.94805437
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84820145
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.79413634
23RNA degradation_Homo sapiens_hsa030181.73796138
24Thyroid cancer_Homo sapiens_hsa052161.73478117
25Adherens junction_Homo sapiens_hsa045201.71221392
26MicroRNAs in cancer_Homo sapiens_hsa052061.67247573
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66953896
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63809201
29Arachidonic acid metabolism_Homo sapiens_hsa005901.61270887
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.58950012
31Colorectal cancer_Homo sapiens_hsa052101.53923551
32TGF-beta signaling pathway_Homo sapiens_hsa043501.53400875
33Basal transcription factors_Homo sapiens_hsa030221.50613595
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48981621
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45392205
36Selenocompound metabolism_Homo sapiens_hsa004501.44021297
37Linoleic acid metabolism_Homo sapiens_hsa005911.43443672
38Non-homologous end-joining_Homo sapiens_hsa034501.41994240
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39585249
40Notch signaling pathway_Homo sapiens_hsa043301.36735207
41Ether lipid metabolism_Homo sapiens_hsa005651.33701723
42HTLV-I infection_Homo sapiens_hsa051661.30692034
43p53 signaling pathway_Homo sapiens_hsa041151.29981722
44One carbon pool by folate_Homo sapiens_hsa006701.29133035
45Glutathione metabolism_Homo sapiens_hsa004801.26475264
46Small cell lung cancer_Homo sapiens_hsa052221.24542068
47Prostate cancer_Homo sapiens_hsa052151.23388425
48Autoimmune thyroid disease_Homo sapiens_hsa053201.20038212
49Butanoate metabolism_Homo sapiens_hsa006501.18898900
50Pathways in cancer_Homo sapiens_hsa052001.16898967
51Sulfur metabolism_Homo sapiens_hsa009201.16775698
52Allograft rejection_Homo sapiens_hsa053301.14344183
53Melanogenesis_Homo sapiens_hsa049161.14186534
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13275191
55Pyrimidine metabolism_Homo sapiens_hsa002401.07422640
56Herpes simplex infection_Homo sapiens_hsa051681.06528899
57Type I diabetes mellitus_Homo sapiens_hsa049401.06153381
58Oocyte meiosis_Homo sapiens_hsa041141.04757813
59Proteoglycans in cancer_Homo sapiens_hsa052051.03199753
60Protein export_Homo sapiens_hsa030601.02975871
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02209414
62Chronic myeloid leukemia_Homo sapiens_hsa052201.02123776
63Axon guidance_Homo sapiens_hsa043601.00166815
64Lysine degradation_Homo sapiens_hsa003100.99022376
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98879859
66Endometrial cancer_Homo sapiens_hsa052130.98580715
67RNA polymerase_Homo sapiens_hsa030200.94701576
68Tryptophan metabolism_Homo sapiens_hsa003800.93702444
69Viral carcinogenesis_Homo sapiens_hsa052030.91314343
70ABC transporters_Homo sapiens_hsa020100.90618424
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.90505245
72Viral myocarditis_Homo sapiens_hsa054160.90136586
73ECM-receptor interaction_Homo sapiens_hsa045120.89046969
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87814711
75Fatty acid biosynthesis_Homo sapiens_hsa000610.87141641
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83071664
77Epstein-Barr virus infection_Homo sapiens_hsa051690.82702527
78Graft-versus-host disease_Homo sapiens_hsa053320.78250298
79Antigen processing and presentation_Homo sapiens_hsa046120.77330325
80Hepatitis B_Homo sapiens_hsa051610.75776033
81Sphingolipid metabolism_Homo sapiens_hsa006000.75329284
82Focal adhesion_Homo sapiens_hsa045100.74621558
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73441891
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71775754
85Acute myeloid leukemia_Homo sapiens_hsa052210.71062267
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71053938
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69836265
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69394274
89Systemic lupus erythematosus_Homo sapiens_hsa053220.65522759
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64531016
91Ovarian steroidogenesis_Homo sapiens_hsa049130.63656823
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62548347
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60810243
94Tight junction_Homo sapiens_hsa045300.58718086
95Melanoma_Homo sapiens_hsa052180.58596189
96N-Glycan biosynthesis_Homo sapiens_hsa005100.56911817
97Fatty acid elongation_Homo sapiens_hsa000620.55851116
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55811078
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55226893
100Measles_Homo sapiens_hsa051620.55057134
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54877680
102Fatty acid metabolism_Homo sapiens_hsa012120.54573407
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54291514
104Alcoholism_Homo sapiens_hsa050340.52466880
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51390805
106Olfactory transduction_Homo sapiens_hsa047400.50792096
107Bladder cancer_Homo sapiens_hsa052190.50455251
108mTOR signaling pathway_Homo sapiens_hsa041500.49490107
109Propanoate metabolism_Homo sapiens_hsa006400.48722472
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48494770
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47681628
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47329287
113Purine metabolism_Homo sapiens_hsa002300.46244029
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.46004211
115Protein digestion and absorption_Homo sapiens_hsa049740.45748573
116Peroxisome_Homo sapiens_hsa041460.45509104
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45359793
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.44690519
119Rap1 signaling pathway_Homo sapiens_hsa040150.44589069
120Serotonergic synapse_Homo sapiens_hsa047260.44120267
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.44110794
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42905744
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.42644328
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.42638207
125Glycerolipid metabolism_Homo sapiens_hsa005610.41738198
126Pancreatic cancer_Homo sapiens_hsa052120.40690053
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.40071239
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39071167
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38992840
130Primary immunodeficiency_Homo sapiens_hsa053400.38940138
131Metabolic pathways_Homo sapiens_hsa011000.38604132
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38087496
133Hematopoietic cell lineage_Homo sapiens_hsa046400.37478783
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35800828
135Steroid biosynthesis_Homo sapiens_hsa001000.35615738
136Renin-angiotensin system_Homo sapiens_hsa046140.35484760
137Shigellosis_Homo sapiens_hsa051310.35286092
138FoxO signaling pathway_Homo sapiens_hsa040680.34853033
139Circadian rhythm_Homo sapiens_hsa047100.34634142
140Non-small cell lung cancer_Homo sapiens_hsa052230.34220096
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34083669
142Salivary secretion_Homo sapiens_hsa049700.32566839
143Renal cell carcinoma_Homo sapiens_hsa052110.30839796
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30381416
145Gap junction_Homo sapiens_hsa045400.30253810
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29999325
147Sulfur relay system_Homo sapiens_hsa041220.29705756
148MAPK signaling pathway_Homo sapiens_hsa040100.29412196
149Platelet activation_Homo sapiens_hsa046110.29196454
150HIF-1 signaling pathway_Homo sapiens_hsa040660.29126199
151T cell receptor signaling pathway_Homo sapiens_hsa046600.27300586
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27174659
153Toxoplasmosis_Homo sapiens_hsa051450.27103776
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24662341
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.23779570

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »