ZC4H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.59394682
2central nervous system myelination (GO:0022010)5.59394682
3neuron cell-cell adhesion (GO:0007158)5.00443274
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46625790
5pyrimidine nucleobase catabolic process (GO:0006208)4.43856233
6presynaptic membrane assembly (GO:0097105)4.21927071
7synaptic vesicle exocytosis (GO:0016079)4.13852014
8postsynaptic membrane organization (GO:0001941)4.06735474
9behavioral response to nicotine (GO:0035095)4.03215514
10vocalization behavior (GO:0071625)4.02757874
11protein localization to synapse (GO:0035418)4.01043450
12presynaptic membrane organization (GO:0097090)3.99546021
13chaperone-mediated protein transport (GO:0072321)3.97415802
14sequestering of actin monomers (GO:0042989)3.96895002
15negative regulation of microtubule polymerization (GO:0031115)3.90390577
16positive regulation of synapse maturation (GO:0090129)3.82182942
17DNA damage response, detection of DNA damage (GO:0042769)3.71588903
18establishment of mitochondrion localization (GO:0051654)3.65389442
19neuron recognition (GO:0008038)3.55608618
20regulation of synaptic vesicle exocytosis (GO:2000300)3.55308367
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.54250911
22regulation of glutamate receptor signaling pathway (GO:1900449)3.52105674
23negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47881042
24DNA double-strand break processing (GO:0000729)3.47013341
25cerebral cortex radially oriented cell migration (GO:0021799)3.45553043
26mechanosensory behavior (GO:0007638)3.42062697
27regulation of synapse maturation (GO:0090128)3.41571040
28axonal fasciculation (GO:0007413)3.39664560
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39367677
30neurotransmitter-gated ion channel clustering (GO:0072578)3.36532055
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.36069762
32protein neddylation (GO:0045116)3.35124062
33regulation of respiratory system process (GO:0044065)3.30484089
34cell migration in hindbrain (GO:0021535)3.29588337
35glutamate secretion (GO:0014047)3.26867308
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26625571
37positive regulation of synapse assembly (GO:0051965)3.25760124
38regulation of synapse structural plasticity (GO:0051823)3.25374068
39viral protein processing (GO:0019082)3.25235089
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24879375
41limb bud formation (GO:0060174)3.24396924
42auditory behavior (GO:0031223)3.21634100
43neural tube formation (GO:0001841)3.20505969
44nucleobase catabolic process (GO:0046113)3.20412036
45cullin deneddylation (GO:0010388)3.15494068
46synaptic transmission, glutamatergic (GO:0035249)3.15467072
47neuron-neuron synaptic transmission (GO:0007270)3.12669203
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10140627
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09311364
50intraciliary transport (GO:0042073)3.08505796
51negative regulation of astrocyte differentiation (GO:0048712)3.08026796
52mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.05006048
53retinal ganglion cell axon guidance (GO:0031290)3.02074026
54regulation of development, heterochronic (GO:0040034)3.01756594
55negative regulation of oligodendrocyte differentiation (GO:0048715)3.01249352
56chondrocyte proliferation (GO:0035988)3.00950890
57gamma-aminobutyric acid transport (GO:0015812)2.99632447
58nonmotile primary cilium assembly (GO:0035058)2.99327511
59synaptic vesicle maturation (GO:0016188)2.96698230
60cerebellar granule cell differentiation (GO:0021707)2.96526222
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94701908
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94630183
63regulation of synaptic vesicle transport (GO:1902803)2.93547631
64olfactory bulb development (GO:0021772)2.88656835
65cochlea development (GO:0090102)2.85977528
66positive regulation of mitochondrial fission (GO:0090141)2.85300798
67microtubule depolymerization (GO:0007019)2.84449702
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83401126
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81991631
70ATP synthesis coupled proton transport (GO:0015986)2.81991631
71dendrite morphogenesis (GO:0048813)2.81819810
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.79823976
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79779789
74forebrain neuron differentiation (GO:0021879)2.77716688
75regulation of respiratory gaseous exchange (GO:0043576)2.76776330
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76675666
77DNA integration (GO:0015074)2.76468851
78mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76160226
79neuronal action potential propagation (GO:0019227)2.75581980
80negative regulation of neurotransmitter transport (GO:0051589)2.73416043
81dendrite development (GO:0016358)2.72622168
82protein deneddylation (GO:0000338)2.72324440
83negative regulation of telomere maintenance (GO:0032205)2.71867959
84protein polyglutamylation (GO:0018095)2.71222271
85regulation of feeding behavior (GO:0060259)2.70579329
86negative regulation of axonogenesis (GO:0050771)2.70336616
87glutamate receptor signaling pathway (GO:0007215)2.70260136
88dendritic spine morphogenesis (GO:0060997)2.69327768
89neurotransmitter secretion (GO:0007269)2.68423480
90protein complex biogenesis (GO:0070271)2.67267659
91axon extension involved in axon guidance (GO:0048846)2.66976993
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.66976993
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.66782484
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.65481836
95central nervous system projection neuron axonogenesis (GO:0021952)2.65271064
96negative regulation of glial cell differentiation (GO:0045686)2.65105881
97response to auditory stimulus (GO:0010996)2.64101727
98neurofilament cytoskeleton organization (GO:0060052)2.63431224
99regulation of synapse organization (GO:0050807)2.63041039
100head development (GO:0060322)2.62112740
101cell proliferation in forebrain (GO:0021846)2.61346399
102sympathetic nervous system development (GO:0048485)2.61250792
103peptidyl-arginine omega-N-methylation (GO:0035247)2.60993015
104exploration behavior (GO:0035640)2.60195433
105hippocampus development (GO:0021766)2.60018110
106somite development (GO:0061053)2.59914588
107spinal cord development (GO:0021510)2.59395148
108regulation of timing of cell differentiation (GO:0048505)2.58861736
109substantia nigra development (GO:0021762)2.58857242
110mitochondrial respiratory chain complex I assembly (GO:0032981)2.58652937
111NADH dehydrogenase complex assembly (GO:0010257)2.58652937
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58652937
113histone H2A acetylation (GO:0043968)2.58594549
114positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.58563873
115mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.58563873
116adult walking behavior (GO:0007628)2.57371937
117protein localization to cilium (GO:0061512)2.57028628
118regulation of neuronal synaptic plasticity (GO:0048168)2.56969048
119regulation of synapse assembly (GO:0051963)2.56847315
120establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55820461
121mitochondrion transport along microtubule (GO:0047497)2.55820461
122mitochondrial respiratory chain complex assembly (GO:0033108)2.55768927
123synapse assembly (GO:0007416)2.54857216
124chromatin remodeling at centromere (GO:0031055)2.53843803
125negative regulation of dendrite development (GO:2000171)2.53275864
126neurotransmitter uptake (GO:0001504)2.52973384
127transmission of nerve impulse (GO:0019226)2.52564080
128regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52033844
129negative regulation of axon extension (GO:0030517)2.51030664
130substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.50732370
131substrate-independent telencephalic tangential migration (GO:0021826)2.50732370
132regulation of neurotransmitter secretion (GO:0046928)2.50516252
133long-chain fatty acid biosynthetic process (GO:0042759)2.50287090
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50132337
135regulation of mitotic spindle checkpoint (GO:1903504)2.50132337
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48498883
137regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48478006
138regulation of collateral sprouting (GO:0048670)2.45617823
139regulation of dopamine metabolic process (GO:0042053)2.45073356
140regulation of catecholamine metabolic process (GO:0042069)2.45073356
141peptidyl-arginine methylation (GO:0018216)2.44873447
142peptidyl-arginine N-methylation (GO:0035246)2.44873447
143positive regulation of membrane potential (GO:0045838)2.44732501
144ubiquinone metabolic process (GO:0006743)2.44383004
145neuron fate determination (GO:0048664)2.44334431
146response to pheromone (GO:0019236)2.43896195
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43781132
148negative regulation of axon guidance (GO:1902668)2.43459220
149water-soluble vitamin biosynthetic process (GO:0042364)2.42384865
150L-serine metabolic process (GO:0006563)2.41620710
151regulation of telomere maintenance (GO:0032204)2.34462169
152regulation of helicase activity (GO:0051095)2.32381261
153cilium morphogenesis (GO:0060271)2.32346716
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32160239
155kidney morphogenesis (GO:0060993)2.31857367
156nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30417443
157establishment of integrated proviral latency (GO:0075713)2.29333470
158organelle disassembly (GO:1903008)2.29098139
159protein-cofactor linkage (GO:0018065)2.27804356
160regulation of cilium movement (GO:0003352)2.26327874
161cholesterol biosynthetic process (GO:0006695)2.26319643
162spliceosomal snRNP assembly (GO:0000387)2.25933352
163base-excision repair, AP site formation (GO:0006285)2.23515490
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.23424850
165regulation of translation, ncRNA-mediated (GO:0045974)2.23424850
166negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23424850
167mRNA splice site selection (GO:0006376)2.21229487
168negative regulation of heart rate (GO:0010459)2.20216642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12353260
2GBX2_23144817_ChIP-Seq_PC3_Human4.27150504
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.93725101
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87731969
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84277206
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82847318
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76089318
8TAF15_26573619_Chip-Seq_HEK293_Human2.73562225
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73454023
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70724261
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.61109307
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58479052
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58479052
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53145146
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51444396
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49248131
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.44832379
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37119049
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37037477
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.33410696
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.33216615
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.31248263
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29601941
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27367441
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24170706
26REST_21632747_ChIP-Seq_MESCs_Mouse2.16458709
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12466432
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07435952
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.04213145
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03101642
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.03009231
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02347627
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99648581
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94726878
35RNF2_27304074_Chip-Seq_NSC_Mouse1.91011488
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89870045
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87521201
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84944557
39P300_19829295_ChIP-Seq_ESCs_Human1.81135793
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81101368
41IRF1_19129219_ChIP-ChIP_H3396_Human1.80682425
42AR_21572438_ChIP-Seq_LNCaP_Human1.79973753
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.79765969
44FUS_26573619_Chip-Seq_HEK293_Human1.77525884
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.77223897
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70923884
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66955909
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65642200
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65095060
50MYC_18940864_ChIP-ChIP_HL60_Human1.60817609
51IGF1R_20145208_ChIP-Seq_DFB_Human1.60428078
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.58225917
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58087914
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.56644958
55ELK1_19687146_ChIP-ChIP_HELA_Human1.54244662
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52716802
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.49544483
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48937961
59EWS_26573619_Chip-Seq_HEK293_Human1.46714875
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.41565449
61SMAD4_21799915_ChIP-Seq_A2780_Human1.40905285
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40657502
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39070257
64VDR_22108803_ChIP-Seq_LS180_Human1.36887386
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.34277690
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34012160
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32996952
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30858916
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30677744
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30021637
71ZNF274_21170338_ChIP-Seq_K562_Hela1.28908022
72DROSHA_22980978_ChIP-Seq_HELA_Human1.25655623
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.24923467
74VDR_23849224_ChIP-Seq_CD4+_Human1.23742686
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22059651
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.22011909
77ER_23166858_ChIP-Seq_MCF-7_Human1.21775110
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20912108
79CBP_20019798_ChIP-Seq_JUKART_Human1.19511891
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19511891
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.15025383
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.14881465
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14537138
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14177674
85AR_25329375_ChIP-Seq_VCAP_Human1.09091181
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09062511
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08629020
88TP53_22573176_ChIP-Seq_HFKS_Human1.08440334
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08032866
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08009984
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07744505
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07031208
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06937194
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06640960
95SOX9_26525672_Chip-Seq_HEART_Mouse1.05796973
96FOXP3_21729870_ChIP-Seq_TREG_Human1.05659921
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05184743
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.04640420
99JUN_21703547_ChIP-Seq_K562_Human1.04296411
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04040693
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03045529
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02768001
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00523346
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00057089
105GABP_19822575_ChIP-Seq_HepG2_Human0.98483206
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97802115
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96730457
108TTF2_22483619_ChIP-Seq_HELA_Human0.96645159
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.96492917
110POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.96350849
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.95787961
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95391063
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95281902
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95051734
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94359580
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94292729
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94200629
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.93824201
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93759241
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93740394
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93607996
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92598555
123MYC_18555785_ChIP-Seq_MESCs_Mouse0.92140777
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91771287
125RUNX2_22187159_ChIP-Seq_PCA_Human0.91740440
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91507591
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91507591
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91381752
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90754648
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.90400826
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.90312963
132HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89477163
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89428968
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.86630882
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85339255
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85084035
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84077734
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.83549076
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83207064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.65451097
2MP0005423_abnormal_somatic_nervous4.03592310
3MP0004859_abnormal_synaptic_plasticity3.27519068
4MP0000566_synostosis3.22277860
5MP0006276_abnormal_autonomic_nervous2.71965220
6MP0000778_abnormal_nervous_system2.68630752
7MP0003635_abnormal_synaptic_transmissio2.68217349
8MP0004270_analgesia2.64372721
9MP0010030_abnormal_orbit_morphology2.47017510
10MP0001529_abnormal_vocalization2.37577577
11MP0002063_abnormal_learning/memory/cond2.33120798
12MP0003122_maternal_imprinting2.23222172
13MP0006292_abnormal_olfactory_placode2.11511349
14MP0008877_abnormal_DNA_methylation2.10428650
15MP0001968_abnormal_touch/_nociception2.08332652
16MP0002064_seizures2.06884282
17MP0009745_abnormal_behavioral_response2.06687873
18MP0002734_abnormal_mechanical_nocicepti2.05881953
19MP0002572_abnormal_emotion/affect_behav1.99445750
20MP0002184_abnormal_innervation1.95641588
21MP0009780_abnormal_chondrocyte_physiolo1.95604101
22MP0002272_abnormal_nervous_system1.91922098
23MP0001188_hyperpigmentation1.90768199
24MP0001486_abnormal_startle_reflex1.87363773
25MP0002736_abnormal_nociception_after1.87088190
26MP0001905_abnormal_dopamine_level1.84628100
27MP0002751_abnormal_autonomic_nervous1.83479400
28MP0002234_abnormal_pharynx_morphology1.80092979
29MP0001293_anophthalmia1.79651900
30MP0009046_muscle_twitch1.72398179
31MP0002735_abnormal_chemical_nociception1.63573344
32MP0004134_abnormal_chest_morphology1.59689437
33MP0005646_abnormal_pituitary_gland1.58660894
34MP0001984_abnormal_olfaction1.58278304
35MP0003890_abnormal_embryonic-extraembry1.57461112
36MP0002067_abnormal_sensory_capabilities1.55718796
37MP0002102_abnormal_ear_morphology1.55095364
38MP0008058_abnormal_DNA_repair1.54111125
39MP0000955_abnormal_spinal_cord1.52108560
40MP0002557_abnormal_social/conspecific_i1.48495246
41MP0003121_genomic_imprinting1.47368293
42MP0002882_abnormal_neuron_morphology1.46675035
43MP0003567_abnormal_fetal_cardiomyocyte1.46469783
44MP0003787_abnormal_imprinting1.45817561
45MP0000049_abnormal_middle_ear1.44022712
46MP0008789_abnormal_olfactory_epithelium1.41140529
47MP0005084_abnormal_gallbladder_morpholo1.39654615
48MP0004811_abnormal_neuron_physiology1.38876262
49MP0005394_taste/olfaction_phenotype1.36290463
50MP0005499_abnormal_olfactory_system1.36290463
51MP0000631_abnormal_neuroendocrine_gland1.35794480
52MP0003938_abnormal_ear_development1.35036916
53MP0002733_abnormal_thermal_nociception1.33161592
54MP0001970_abnormal_pain_threshold1.31547734
55MP0008569_lethality_at_weaning1.31077446
56MP0001440_abnormal_grooming_behavior1.28764458
57MP0004924_abnormal_behavior1.28633954
58MP0005386_behavior/neurological_phenoty1.28633954
59MP0002152_abnormal_brain_morphology1.26882945
60MP0004742_abnormal_vestibular_system1.26231293
61MP0002938_white_spotting1.20090573
62MP0003119_abnormal_digestive_system1.19496173
63MP0005171_absent_coat_pigmentation1.19231293
64MP0008995_early_reproductive_senescence1.17253176
65MP0001286_abnormal_eye_development1.16658704
66MP0003011_delayed_dark_adaptation1.16307868
67MP0003861_abnormal_nervous_system1.15700222
68MP0002752_abnormal_somatic_nervous1.14994861
69MP0002638_abnormal_pupillary_reflex1.12377323
70MP0005253_abnormal_eye_physiology1.11930671
71MP0002066_abnormal_motor_capabilities/c1.09619189
72MP0001299_abnormal_eye_distance/1.09199913
73MP0009250_abnormal_appendicular_skeleto1.07981325
74MP0004858_abnormal_nervous_system1.07901647
75MP0003136_yellow_coat_color1.04767540
76MP0004142_abnormal_muscle_tone1.04219017
77MP0002653_abnormal_ependyma_morphology1.03466639
78MP0002822_catalepsy1.01274595
79MP0005551_abnormal_eye_electrophysiolog1.00857890
80MP0003755_abnormal_palate_morphology1.00611377
81MP0000026_abnormal_inner_ear0.99286827
82MP0003942_abnormal_urinary_system0.98879708
83MP0003385_abnormal_body_wall0.98561260
84MP0003634_abnormal_glial_cell0.97554013
85MP0002249_abnormal_larynx_morphology0.97088053
86MP0002697_abnormal_eye_size0.96666880
87MP0002089_abnormal_postnatal_growth/wei0.95084790
88MP0005645_abnormal_hypothalamus_physiol0.95010858
89MP0005248_abnormal_Harderian_gland0.94685422
90MP0001502_abnormal_circadian_rhythm0.94223913
91MP0004885_abnormal_endolymph0.94081260
92MP0005195_abnormal_posterior_eye0.91110015
93MP0006072_abnormal_retinal_apoptosis0.90697430
94MP0005391_vision/eye_phenotype0.90263169
95MP0003718_maternal_effect0.89661373
96MP0001485_abnormal_pinna_reflex0.89418054
97MP0001986_abnormal_taste_sensitivity0.88179176
98MP0001963_abnormal_hearing_physiology0.88038447
99MP0000751_myopathy0.86419312
100MP0002233_abnormal_nose_morphology0.86309723
101MP0001177_atelectasis0.85411600
102MP0000920_abnormal_myelination0.84216001
103MP0003123_paternal_imprinting0.84102589
104MP0002163_abnormal_gland_morphology0.83356619
105MP0005409_darkened_coat_color0.81646142
106MP0000537_abnormal_urethra_morphology0.81328300
107MP0002282_abnormal_trachea_morphology0.81070764
108MP0002229_neurodegeneration0.80980181
109MP0004233_abnormal_muscle_weight0.79589324
110MP0003183_abnormal_peptide_metabolism0.79164987
111MP0002069_abnormal_eating/drinking_beha0.76629139
112MP0001943_abnormal_respiration0.76327710
113MP0000569_abnormal_digit_pigmentation0.75664365
114MP0003315_abnormal_perineum_morphology0.74993286
115MP0003631_nervous_system_phenotype0.74311096
116MP0008932_abnormal_embryonic_tissue0.73201747
117MP0005187_abnormal_penis_morphology0.73154586
118MP0004133_heterotaxia0.72897993
119MP0003937_abnormal_limbs/digits/tail_de0.72431507
120MP0001501_abnormal_sleep_pattern0.72351930
121MP0006035_abnormal_mitochondrial_morpho0.72161426
122MP0003698_abnormal_male_reproductive0.71637234
123MP0002081_perinatal_lethality0.71341661
124MP0002116_abnormal_craniofacial_bone0.71161078
125MP0000534_abnormal_ureter_morphology0.70553017
126MP0010094_abnormal_chromosome_stability0.68807638
127MP0003633_abnormal_nervous_system0.68472545
128MP0002837_dystrophic_cardiac_calcinosis0.68059243

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.75672136
2Myokymia (HP:0002411)3.60863360
3Epileptic encephalopathy (HP:0200134)3.40004250
4Gait imbalance (HP:0002141)3.39308809
5Colon cancer (HP:0003003)3.08968668
6Thickened helices (HP:0000391)3.05999756
7Megalencephaly (HP:0001355)3.03362419
8Atonic seizures (HP:0010819)3.02076243
9Medial flaring of the eyebrow (HP:0010747)2.91392448
10Congenital primary aphakia (HP:0007707)2.90182529
11Degeneration of the lateral corticospinal tracts (HP:0002314)2.89653903
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89653903
13Hyperglycinemia (HP:0002154)2.89501482
14Hyperventilation (HP:0002883)2.84514780
15Abnormal hair whorl (HP:0010721)2.82979646
16Failure to thrive in infancy (HP:0001531)2.80386878
17Nephronophthisis (HP:0000090)2.79612119
18Pancreatic cysts (HP:0001737)2.75563577
19Genital tract atresia (HP:0001827)2.75457208
20Vaginal atresia (HP:0000148)2.74154281
21Abnormality of glycolysis (HP:0004366)2.73758129
22Increased serum pyruvate (HP:0003542)2.73758129
23Alacrima (HP:0000522)2.73118532
24Ankle clonus (HP:0011448)2.71539545
25Cortical dysplasia (HP:0002539)2.70885100
26Limb dystonia (HP:0002451)2.69472467
27Nephrogenic diabetes insipidus (HP:0009806)2.68677200
28Abnormality of the corticospinal tract (HP:0002492)2.65449384
29Specific learning disability (HP:0001328)2.56587453
30Broad-based gait (HP:0002136)2.54225636
31Progressive cerebellar ataxia (HP:0002073)2.52958154
32Septo-optic dysplasia (HP:0100842)2.51494223
33Aplasia involving bones of the extremities (HP:0009825)2.49816213
34Aplasia involving bones of the upper limbs (HP:0009823)2.49816213
35Aplasia of the phalanges of the hand (HP:0009802)2.49816213
36Abnormality of midbrain morphology (HP:0002418)2.45848374
37Molar tooth sign on MRI (HP:0002419)2.45848374
38Fetal akinesia sequence (HP:0001989)2.45662705
39Focal seizures (HP:0007359)2.44806250
40Acute encephalopathy (HP:0006846)2.38000931
41Hypothermia (HP:0002045)2.36756785
42Narrow nasal bridge (HP:0000446)2.36370906
43Partial duplication of thumb phalanx (HP:0009944)2.36234562
44Thyroid-stimulating hormone excess (HP:0002925)2.34036491
45Coronal craniosynostosis (HP:0004440)2.33585076
46Methylmalonic acidemia (HP:0002912)2.31727278
47Hepatoblastoma (HP:0002884)2.29840837
48Abnormality of incisor morphology (HP:0011063)2.29425715
49Neuroendocrine neoplasm (HP:0100634)2.29413186
50Patellar aplasia (HP:0006443)2.21923347
51Pachygyria (HP:0001302)2.21552362
52Insidious onset (HP:0003587)2.21495666
53Termporal pattern (HP:0011008)2.21495666
54Febrile seizures (HP:0002373)2.20461540
55Abnormality of the renal medulla (HP:0100957)2.20107893
56Oligodactyly (hands) (HP:0001180)2.18998044
57Rib fusion (HP:0000902)2.18699896
58Pendular nystagmus (HP:0012043)2.18326734
59Spastic gait (HP:0002064)2.18100897
60Abnormality of the middle phalanges of the toes (HP:0010183)2.16862273
61* Drooling (HP:0002307)2.16471909
62Sclerocornea (HP:0000647)2.14320602
63Oligodactyly (HP:0012165)2.13777258
64Optic nerve hypoplasia (HP:0000609)2.13287422
65Partial duplication of the phalanx of hand (HP:0009999)2.12857966
66Intestinal atresia (HP:0011100)2.12415763
67Urinary bladder sphincter dysfunction (HP:0002839)2.11254580
68Abnormality of the metopic suture (HP:0005556)2.10001587
69Truncal ataxia (HP:0002078)2.09504629
70Progressive macrocephaly (HP:0004481)2.08619673
71Narrow forehead (HP:0000341)2.08572650
72Decreased lacrimation (HP:0000633)2.07773341
73Urinary urgency (HP:0000012)2.07679586
74Pheochromocytoma (HP:0002666)2.07609859
75Lissencephaly (HP:0001339)2.07260158
76Aplasia/Hypoplasia of the patella (HP:0006498)2.07226935
77True hermaphroditism (HP:0010459)2.06777012
78Cerebral hypomyelination (HP:0006808)2.04698192
79Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04538407
80Hypoplasia of the brainstem (HP:0002365)2.04538407
81Absence seizures (HP:0002121)2.03708481
82Abnormality of the labia minora (HP:0012880)2.02780240
83Amblyopia (HP:0000646)2.02633214
84Split foot (HP:0001839)2.01593796
85Anophthalmia (HP:0000528)2.01282967
86Hypsarrhythmia (HP:0002521)1.98746333
87Postaxial foot polydactyly (HP:0001830)1.98344740
88Preaxial hand polydactyly (HP:0001177)1.97518399
89Recurrent corneal erosions (HP:0000495)1.97426899
90Anencephaly (HP:0002323)1.97417860
91Aplasia/Hypoplasia of the lens (HP:0008063)1.96867080
92Poor coordination (HP:0002370)1.95710996
93Supranuclear gaze palsy (HP:0000605)1.94950129
94Polyphagia (HP:0002591)1.93058774
95Dandy-Walker malformation (HP:0001305)1.89635053
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89588906
97Retinal dysplasia (HP:0007973)1.89536001
98Impaired vibration sensation in the lower limbs (HP:0002166)1.89438503
99Esotropia (HP:0000565)1.89354926
100* Excessive salivation (HP:0003781)1.88701539
101Poor suck (HP:0002033)1.88521156
102Renal hypoplasia (HP:0000089)1.88485336
103Decreased testicular size (HP:0008734)1.86969421
104Duplication of thumb phalanx (HP:0009942)1.86593403
105Protruding tongue (HP:0010808)1.86439381
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.86391029
107Methylmalonic aciduria (HP:0012120)1.85880696
108Hypoplastic pelvis (HP:0008839)1.85757735
109Neonatal short-limb short stature (HP:0008921)1.85303071
110Hepatocellular necrosis (HP:0001404)1.84715833
111EEG with generalized epileptiform discharges (HP:0011198)1.84548666
112Dialeptic seizures (HP:0011146)1.83247422
113Hemivertebrae (HP:0002937)1.82953789
114Esophageal atresia (HP:0002032)1.81516675
115Absent speech (HP:0001344)1.81453797
116Acute necrotizing encephalopathy (HP:0006965)1.81371261
117Abnormality of macular pigmentation (HP:0008002)1.81282302
118Scanning speech (HP:0002168)1.81267767
119Hip dysplasia (HP:0001385)1.80936564
120Micropenis (HP:0000054)1.80886994
121Growth hormone deficiency (HP:0000824)1.80631093
122Abnormality of the antihelix (HP:0009738)1.79904373
123Bowel incontinence (HP:0002607)1.79609999
124Labial hypoplasia (HP:0000066)1.79133219
125Increased CSF lactate (HP:0002490)1.78844904
126Spinal canal stenosis (HP:0003416)1.77529014
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.77226622
128Visual hallucinations (HP:0002367)1.75547123
129Lower limb muscle weakness (HP:0007340)1.75451618
130Spastic tetraplegia (HP:0002510)1.74229464
131Scrotal hypoplasia (HP:0000046)1.73002921
132Gaze-evoked nystagmus (HP:0000640)1.71614121
133Stenosis of the external auditory canal (HP:0000402)1.71377919
134Hypoplastic female external genitalia (HP:0012815)1.71134288
135Broad foot (HP:0001769)1.70362541
136Agitation (HP:0000713)1.69740238
137Cystic liver disease (HP:0006706)1.69185772
138Overfolded helix (HP:0000396)1.68440893
139Trigonocephaly (HP:0000243)1.67392442
140Reticulocytopenia (HP:0001896)1.67231502
141Hepatic necrosis (HP:0002605)1.66723092
142Increased hepatocellular lipid droplets (HP:0006565)1.65831953
143Optic nerve coloboma (HP:0000588)1.65514406
144Abnormal mitochondria in muscle tissue (HP:0008316)1.65475708
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.65134177
146Inability to walk (HP:0002540)1.64563158
147Abnormality of the lacrimal duct (HP:0011481)1.64473782
148Nasolacrimal duct obstruction (HP:0000579)1.64307780
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.64197086
150Shoulder girdle muscle weakness (HP:0003547)1.64163191
151Optic disc pallor (HP:0000543)1.64144012
152Meckel diverticulum (HP:0002245)1.63831198
153Cupped ear (HP:0000378)1.63752180
154Cerebral edema (HP:0002181)1.63695574
155Neurofibrillary tangles (HP:0002185)1.63524127
156Pancreatic fibrosis (HP:0100732)1.63398232
157Abnormality of glycine metabolism (HP:0010895)1.62975290
158Leukodystrophy (HP:0002415)1.61148531
159Epileptiform EEG discharges (HP:0011182)1.58630807
160Progressive inability to walk (HP:0002505)1.58277742
161Abnormal large intestine physiology (HP:0012700)1.57936082
162Postaxial hand polydactyly (HP:0001162)1.57599361
163Mitochondrial inheritance (HP:0001427)1.57196467
164Action tremor (HP:0002345)1.56761715
165Heterochromia iridis (HP:0001100)1.56716291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.15150807
2MARK13.80263773
3MAPK133.30337045
4WNK33.28111916
5TRIM283.01588401
6MAP4K22.84456771
7SIK32.62888230
8CDK192.51154295
9BUB12.47857403
10PRPF4B2.39588295
11DYRK22.38577021
12BCR2.35331008
13INSRR2.25512782
14TNIK2.20175882
15EEF2K2.11990052
16MINK12.08175984
17MAP2K72.08047263
18MAPKAPK32.00248563
19MAP3K121.98976491
20NUAK11.91085526
21NTRK31.88261090
22UHMK11.81510868
23SRPK11.80300822
24OXSR11.79293255
25MAPKAPK51.78912505
26LIMK11.75492096
27EPHA41.70421139
28MAP3K41.70084135
29VRK21.68703905
30NTRK21.67659852
31SGK2231.58293079
32SGK4941.58293079
33DAPK11.57384063
34BMPR1B1.55909036
35KSR11.52354802
36PLK21.50839466
37VRK11.50474740
38CDC71.49381001
39ERBB31.33047298
40ZAK1.32703636
41STK161.29067079
42PINK11.28745802
43DAPK21.28552513
44CDK81.27740469
45MKNK21.24196840
46FGFR21.22067877
47MAP3K91.18699987
48PLK41.15214859
49CDK181.12889592
50DYRK31.12049461
51CSNK1G31.11798698
52DYRK1B1.10742432
53ADRBK21.10449501
54CDK141.08871164
55BCKDK1.07250552
56PKN11.05879744
57CDK51.02523015
58ROCK20.99164678
59CDK150.97873225
60RPS6KA40.94814022
61FGFR10.93267627
62CDK11A0.91147274
63CSNK1G20.90815691
64CAMK2B0.89477506
65TAF10.88687107
66PAK60.87580283
67CCNB10.86237505
68CSNK1A1L0.83085800
69SGK20.82192240
70RPS6KA20.79758476
71DYRK1A0.79749822
72TSSK60.78283506
73MARK20.75901985
74PHKG20.75829358
75PHKG10.75829358
76MAP2K40.75352688
77GRK10.72071530
78EPHA30.68158440
79NEK10.67431033
80CAMK2A0.66522106
81PLK10.65540033
82STK390.65421046
83PRKCG0.64640149
84CAMKK20.62601685
85TESK20.61762308
86PLK30.59307559
87YES10.58552937
88MAP3K60.57896744
89FLT30.57882684
90PNCK0.57195057
91CSNK1G10.55326363
92CDK30.55026970
93MKNK10.54910388
94CSNK1E0.53447143
95GRK50.53326837
96TYRO30.52341280
97BRAF0.49799712
98ILK0.49793037
99PRKCE0.49740049
100ATR0.49601346
101CAMK40.48259628
102AKT30.47917247
103ADRBK10.47602859
104ATM0.47245945
105TRPM70.46968064
106SIK20.46434036
107MAPK120.45948376
108TLK10.44348501
109EPHB20.43440812
110CSNK1A10.43293206
111CAMK2D0.42657563
112PASK0.41885765
113BRSK10.41232064
114ROCK10.41052696
115PRKCZ0.40880467
116NME10.39936882
117PRKACA0.39818826
118MAPK90.39745924
119ERBB20.39413009
120CSNK1D0.38531320
121PRKDC0.37653099
122AURKB0.37266477
123TTK0.35735125
124ARAF0.35472449
125STK38L0.34901146
126CHEK20.34555480
127LATS10.34480266
128NTRK10.33731288
129TIE10.33419354
130FGFR30.32968697
131PBK0.32535232
132WNK40.32505833
133PAK30.31885375
134FRK0.31090029
135DAPK30.30541976
136KSR20.30083452
137PRKD30.29829822
138RPS6KB10.28084886
139BMPR20.27584679
140CAMK10.26906400

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19853217
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99684026
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49861367
4Olfactory transduction_Homo sapiens_hsa047402.43331557
5GABAergic synapse_Homo sapiens_hsa047272.43018874
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33780965
7Circadian entrainment_Homo sapiens_hsa047132.28913561
8Morphine addiction_Homo sapiens_hsa050322.22239446
9Glutamatergic synapse_Homo sapiens_hsa047242.18459116
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17322069
11Collecting duct acid secretion_Homo sapiens_hsa049662.09480170
12Axon guidance_Homo sapiens_hsa043602.09138533
13Dopaminergic synapse_Homo sapiens_hsa047282.05561598
14Oxidative phosphorylation_Homo sapiens_hsa001902.02043849
15Serotonergic synapse_Homo sapiens_hsa047261.93362907
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90939128
17Fanconi anemia pathway_Homo sapiens_hsa034601.83766058
18Homologous recombination_Homo sapiens_hsa034401.76493825
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75938064
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73686905
21Parkinsons disease_Homo sapiens_hsa050121.71819018
22Ribosome_Homo sapiens_hsa030101.71598262
23Amphetamine addiction_Homo sapiens_hsa050311.70687676
24Phototransduction_Homo sapiens_hsa047441.70332285
25Vibrio cholerae infection_Homo sapiens_hsa051101.68036652
26Basal transcription factors_Homo sapiens_hsa030221.66363327
27Butanoate metabolism_Homo sapiens_hsa006501.63943896
28Propanoate metabolism_Homo sapiens_hsa006401.61180231
29Non-homologous end-joining_Homo sapiens_hsa034501.60286432
30Cholinergic synapse_Homo sapiens_hsa047251.58539876
31Long-term potentiation_Homo sapiens_hsa047201.57549553
32Base excision repair_Homo sapiens_hsa034101.54410726
33Long-term depression_Homo sapiens_hsa047301.53246684
34Taste transduction_Homo sapiens_hsa047421.52028598
35Hedgehog signaling pathway_Homo sapiens_hsa043401.48871019
36Gap junction_Homo sapiens_hsa045401.47763035
37Alzheimers disease_Homo sapiens_hsa050101.46717999
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30217829
39Cocaine addiction_Homo sapiens_hsa050301.28247661
40Renin secretion_Homo sapiens_hsa049241.28030077
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27823682
42RNA degradation_Homo sapiens_hsa030181.27655775
43Oxytocin signaling pathway_Homo sapiens_hsa049211.27019413
44RNA transport_Homo sapiens_hsa030131.23154783
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22704810
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21106620
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20234298
48DNA replication_Homo sapiens_hsa030301.18050742
49Cardiac muscle contraction_Homo sapiens_hsa042601.17289621
50Huntingtons disease_Homo sapiens_hsa050161.16210107
51Colorectal cancer_Homo sapiens_hsa052101.15390500
52Salivary secretion_Homo sapiens_hsa049701.15176553
53Alcoholism_Homo sapiens_hsa050341.12956833
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11371472
55Oocyte meiosis_Homo sapiens_hsa041141.10285309
56Selenocompound metabolism_Homo sapiens_hsa004501.09501502
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09430419
58Insulin secretion_Homo sapiens_hsa049111.09212974
59Basal cell carcinoma_Homo sapiens_hsa052171.07054585
60Melanogenesis_Homo sapiens_hsa049161.03178750
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99048693
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96088124
63Pyrimidine metabolism_Homo sapiens_hsa002400.95368950
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.94834012
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94795757
66ErbB signaling pathway_Homo sapiens_hsa040120.94531533
67Gastric acid secretion_Homo sapiens_hsa049710.93645793
68Pyruvate metabolism_Homo sapiens_hsa006200.92737550
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92085256
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91538669
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90689901
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90459264
73Proteasome_Homo sapiens_hsa030500.87738551
74Nucleotide excision repair_Homo sapiens_hsa034200.86571846
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85047975
76Wnt signaling pathway_Homo sapiens_hsa043100.83807698
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83033910
78Calcium signaling pathway_Homo sapiens_hsa040200.83002929
79Ras signaling pathway_Homo sapiens_hsa040140.82523202
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82314919
81cAMP signaling pathway_Homo sapiens_hsa040240.80910736
82Spliceosome_Homo sapiens_hsa030400.80702024
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77005341
84Peroxisome_Homo sapiens_hsa041460.76930767
85GnRH signaling pathway_Homo sapiens_hsa049120.73996221
86beta-Alanine metabolism_Homo sapiens_hsa004100.73457727
87Fatty acid elongation_Homo sapiens_hsa000620.72623347
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72515119
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.71895162
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71421847
91Linoleic acid metabolism_Homo sapiens_hsa005910.71399741
92One carbon pool by folate_Homo sapiens_hsa006700.71188261
93Phagosome_Homo sapiens_hsa041450.70615672
94Hippo signaling pathway_Homo sapiens_hsa043900.69538203
95Biosynthesis of amino acids_Homo sapiens_hsa012300.68877222
96Glioma_Homo sapiens_hsa052140.65222733
97Metabolic pathways_Homo sapiens_hsa011000.65052722
98Ether lipid metabolism_Homo sapiens_hsa005650.65036533
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63734748
100MAPK signaling pathway_Homo sapiens_hsa040100.63432263
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63206848
102Renal cell carcinoma_Homo sapiens_hsa052110.62647390
103mRNA surveillance pathway_Homo sapiens_hsa030150.60650999
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60270399
105RNA polymerase_Homo sapiens_hsa030200.60145622
106Rap1 signaling pathway_Homo sapiens_hsa040150.60051686
107Chemical carcinogenesis_Homo sapiens_hsa052040.59771083
108Endometrial cancer_Homo sapiens_hsa052130.58353888
109Notch signaling pathway_Homo sapiens_hsa043300.58121960
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57345502
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57199402
112Caffeine metabolism_Homo sapiens_hsa002320.56765750
113Retinol metabolism_Homo sapiens_hsa008300.55400776
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54707004
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54655190
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.54176985
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54062333
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53547064
119Steroid biosynthesis_Homo sapiens_hsa001000.53497659
120Arginine and proline metabolism_Homo sapiens_hsa003300.53486387
121Protein export_Homo sapiens_hsa030600.52757624
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50679267
123Rheumatoid arthritis_Homo sapiens_hsa053230.50244340
124Fatty acid metabolism_Homo sapiens_hsa012120.49927372
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49652640
126Estrogen signaling pathway_Homo sapiens_hsa049150.48711475
127Regulation of autophagy_Homo sapiens_hsa041400.47860434
128Cell cycle_Homo sapiens_hsa041100.47859326
129Tryptophan metabolism_Homo sapiens_hsa003800.47268804
130Melanoma_Homo sapiens_hsa052180.45414405
131Carbon metabolism_Homo sapiens_hsa012000.44892349
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44003849
133Glutathione metabolism_Homo sapiens_hsa004800.43481953
134Endocytosis_Homo sapiens_hsa041440.41982972
135N-Glycan biosynthesis_Homo sapiens_hsa005100.41154090
136Circadian rhythm_Homo sapiens_hsa047100.40621680
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.39659706
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39179000
139Mismatch repair_Homo sapiens_hsa034300.38647736
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.38573354
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38109900
142Prion diseases_Homo sapiens_hsa050200.37388100
143Purine metabolism_Homo sapiens_hsa002300.36419084
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36158690
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35355489
146Dilated cardiomyopathy_Homo sapiens_hsa054140.34927690
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34697625

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