ZCCHC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.01110116
2DNA replication checkpoint (GO:0000076)4.79123936
3mitotic metaphase plate congression (GO:0007080)4.78896443
4CENP-A containing nucleosome assembly (GO:0034080)4.69506893
5DNA deamination (GO:0045006)4.67631600
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61524979
7chromatin remodeling at centromere (GO:0031055)4.53117655
8maturation of SSU-rRNA (GO:0030490)4.39720938
9protein localization to kinetochore (GO:0034501)4.24138922
10protein neddylation (GO:0045116)4.18727642
11respiratory chain complex IV assembly (GO:0008535)4.18629092
12DNA replication initiation (GO:0006270)4.16495587
13attachment of spindle microtubules to kinetochore (GO:0008608)4.16441450
14telomere maintenance via semi-conservative replication (GO:0032201)4.10521972
15kinetochore organization (GO:0051383)4.10134678
16DNA replication-independent nucleosome organization (GO:0034724)4.10005968
17DNA replication-independent nucleosome assembly (GO:0006336)4.10005968
18metaphase plate congression (GO:0051310)4.09645860
19proteasome assembly (GO:0043248)4.08874323
20kinetochore assembly (GO:0051382)4.07195221
21ribosomal small subunit assembly (GO:0000028)4.06542763
22DNA strand elongation involved in DNA replication (GO:0006271)3.98051125
23protein complex biogenesis (GO:0070271)3.93947726
24chaperone-mediated protein transport (GO:0072321)3.92900922
25ATP synthesis coupled proton transport (GO:0015986)3.91357359
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.91357359
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91102637
28telomere maintenance via recombination (GO:0000722)3.89726976
29maturation of 5.8S rRNA (GO:0000460)3.86899663
30ribosomal small subunit biogenesis (GO:0042274)3.86860856
31mitochondrial respiratory chain complex assembly (GO:0033108)3.86164104
32ribosome biogenesis (GO:0042254)3.85596870
33histone exchange (GO:0043486)3.85374698
34rRNA modification (GO:0000154)3.84545087
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79357468
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.79357468
37NADH dehydrogenase complex assembly (GO:0010257)3.79357468
38DNA strand elongation (GO:0022616)3.78214910
39DNA catabolic process, exonucleolytic (GO:0000738)3.77846316
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.77222302
41ribosome assembly (GO:0042255)3.73243986
42protein K6-linked ubiquitination (GO:0085020)3.73076788
43ribonucleoprotein complex biogenesis (GO:0022613)3.72411829
44establishment of chromosome localization (GO:0051303)3.65705503
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.65289955
46regulation of mitotic spindle checkpoint (GO:1903504)3.65289955
47protein localization to chromosome, centromeric region (GO:0071459)3.64884650
48meiotic chromosome segregation (GO:0045132)3.63803122
49cytochrome complex assembly (GO:0017004)3.58571652
50formation of translation preinitiation complex (GO:0001731)3.58236397
51mitotic recombination (GO:0006312)3.57886431
52rRNA processing (GO:0006364)3.54097668
537-methylguanosine mRNA capping (GO:0006370)3.54034930
54RNA capping (GO:0036260)3.52720825
557-methylguanosine RNA capping (GO:0009452)3.52720825
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.51697546
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.50622426
58DNA damage response, detection of DNA damage (GO:0042769)3.48547496
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.48232902
60water-soluble vitamin biosynthetic process (GO:0042364)3.46021305
61pseudouridine synthesis (GO:0001522)3.45316505
62termination of RNA polymerase III transcription (GO:0006386)3.44318880
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.44318880
64nucleobase biosynthetic process (GO:0046112)3.43691951
65telomere maintenance via telomere lengthening (GO:0010833)3.41206631
66respiratory electron transport chain (GO:0022904)3.40932218
67viral transcription (GO:0019083)3.40777159
68rRNA metabolic process (GO:0016072)3.40493901
69translational termination (GO:0006415)3.40226814
70spliceosomal snRNP assembly (GO:0000387)3.39353976
71electron transport chain (GO:0022900)3.35888367
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35513801
73purine nucleobase biosynthetic process (GO:0009113)3.35270339
74regulation of DNA endoreduplication (GO:0032875)3.33673159
75transcription-coupled nucleotide-excision repair (GO:0006283)3.33484073
76termination of RNA polymerase I transcription (GO:0006363)3.30078159
77DNA replication-dependent nucleosome assembly (GO:0006335)3.29978534
78DNA replication-dependent nucleosome organization (GO:0034723)3.29978534
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29184099
80ribosomal large subunit biogenesis (GO:0042273)3.29040323
81transcription elongation from RNA polymerase I promoter (GO:0006362)3.24141198
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23398074
83mitotic chromosome condensation (GO:0007076)3.22539807
84transcription from RNA polymerase I promoter (GO:0006360)3.22321402
85rRNA methylation (GO:0031167)3.20433286
86mitotic nuclear envelope disassembly (GO:0007077)3.19972141
87establishment of protein localization to mitochondrial membrane (GO:0090151)3.19960318
88viral mRNA export from host cell nucleus (GO:0046784)3.19115894
89regulation of spindle organization (GO:0090224)3.18275882
90translational initiation (GO:0006413)3.16248006
91replication fork processing (GO:0031297)3.16166932
92postreplication repair (GO:0006301)3.16063202
93protein deneddylation (GO:0000338)3.14607701
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11152458
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.10583336
96establishment of integrated proviral latency (GO:0075713)3.08482338
97regulation of mitochondrial translation (GO:0070129)3.07072838
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05611719
99regulation of helicase activity (GO:0051095)3.05536315
100mitochondrial DNA replication (GO:0006264)3.05351830
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03413079
102negative regulation of ligase activity (GO:0051352)3.03413079
103mitotic sister chromatid segregation (GO:0000070)3.03041878
104translational elongation (GO:0006414)3.01359183
105centriole replication (GO:0007099)2.99084839
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98891908
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98891908
108spliceosomal complex assembly (GO:0000245)2.98439707
109spindle checkpoint (GO:0031577)2.97095282
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95393721
111cellular component biogenesis (GO:0044085)2.94611409
112nuclear envelope disassembly (GO:0051081)2.94406383
113membrane disassembly (GO:0030397)2.94406383
114recombinational repair (GO:0000725)2.94130954
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94030330
116histone mRNA metabolic process (GO:0008334)2.92631982
117G1/S transition of mitotic cell cycle (GO:0000082)2.92582498
118cell cycle G1/S phase transition (GO:0044843)2.92582498
119DNA ligation (GO:0006266)2.92152504
120double-strand break repair via homologous recombination (GO:0000724)2.91341457
121cullin deneddylation (GO:0010388)2.90450784
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90241574
123chromosome segregation (GO:0007059)2.90165567
124cotranslational protein targeting to membrane (GO:0006613)2.89409284
125protein-cofactor linkage (GO:0018065)2.87608736
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86918544
127transcription initiation from RNA polymerase I promoter (GO:0006361)2.86775052
128protein targeting to ER (GO:0045047)2.85522772
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85425122
130platelet dense granule organization (GO:0060155)2.85343712
131peptidyl-histidine modification (GO:0018202)2.85326675
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85237738
133transcription elongation from RNA polymerase II promoter (GO:0006368)2.84736404
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.83455169
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83455169
136DNA-dependent DNA replication (GO:0006261)2.82249774
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80875675
138positive regulation of chromosome segregation (GO:0051984)2.80242857
139translation (GO:0006412)2.79107969
140regulation of meiosis I (GO:0060631)2.77148158
141DNA-templated transcription, termination (GO:0006353)2.76653053
142chromatin assembly or disassembly (GO:0006333)2.75211331
143regulation of cellular amino acid metabolic process (GO:0006521)2.73713940
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73378591
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73140934
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73140424
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73140424
148signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73140424
149response to pheromone (GO:0019236)2.71779530
150positive regulation of ligase activity (GO:0051351)2.66197241
151negative regulation of DNA recombination (GO:0045910)2.66075740
152protein targeting to mitochondrion (GO:0006626)2.65627864
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65412828
154intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65412828
155telomere maintenance via telomerase (GO:0007004)2.65385871
156mitotic spindle checkpoint (GO:0071174)2.64842267
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64645412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37381324
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33861390
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02179034
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.61057665
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.56098438
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52228475
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40395231
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.37410723
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36698018
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.13533613
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95220929
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92498359
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89189733
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87978786
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86887284
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74562639
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73843396
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62464724
19VDR_23849224_ChIP-Seq_CD4+_Human2.57623659
20ZNF274_21170338_ChIP-Seq_K562_Hela2.52338660
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44707832
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40519100
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29418766
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26008515
25XRN2_22483619_ChIP-Seq_HELA_Human2.21446894
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19930143
27AR_21909140_ChIP-Seq_LNCAP_Human2.18375095
28DCP1A_22483619_ChIP-Seq_HELA_Human2.17063773
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14820930
30EWS_26573619_Chip-Seq_HEK293_Human2.14807831
31VDR_22108803_ChIP-Seq_LS180_Human2.13155938
32FOXP3_21729870_ChIP-Seq_TREG_Human2.12100869
33FUS_26573619_Chip-Seq_HEK293_Human2.11607645
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08476839
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03486187
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95999786
37IGF1R_20145208_ChIP-Seq_DFB_Human1.95284520
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.94438756
39GABP_19822575_ChIP-Seq_HepG2_Human1.94242502
40ELK1_19687146_ChIP-ChIP_HELA_Human1.94117191
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93880757
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93145248
43* TTF2_22483619_ChIP-Seq_HELA_Human1.91649178
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89154411
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87136500
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84991974
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84901705
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.84267450
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80283858
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79706430
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78801191
52TAF15_26573619_Chip-Seq_HEK293_Human1.76035275
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.73685478
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.73584020
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70546518
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60369602
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59675325
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58032130
59P300_19829295_ChIP-Seq_ESCs_Human1.56781686
60* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54288771
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.52488858
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52125874
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51717205
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51311372
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49828528
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49641173
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.46075568
68MYC_18940864_ChIP-ChIP_HL60_Human1.37522486
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35504477
70* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35231290
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29653183
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28875907
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27538543
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24930743
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24886700
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.23745466
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.22531274
78CIITA_25753668_ChIP-Seq_RAJI_Human1.22052108
79KDM5A_27292631_Chip-Seq_BREAST_Human1.21989589
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20882038
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.19615767
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18566626
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18033369
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18033369
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18033369
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17942003
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17878785
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17835759
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17669343
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15858243
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.14857516
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12064078
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09485383
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09256338
95* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09105730
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08744550
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.07580394
98TP53_22573176_ChIP-Seq_HFKS_Human1.07576111
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06112765
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04837757
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04007844
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03228865
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03126932
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01796134
105IRF1_19129219_ChIP-ChIP_H3396_Human1.00710934
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00036852
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99988420
108ER_23166858_ChIP-Seq_MCF-7_Human0.99793656
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99677126
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99532833
111GBX2_23144817_ChIP-Seq_PC3_Human0.98828753
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98754720
113SOX2_19829295_ChIP-Seq_ESCs_Human0.97441689
114NANOG_19829295_ChIP-Seq_ESCs_Human0.97441689
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96646752
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96595622
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.96191447
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94615522
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.91953514
120BCAT_22108803_ChIP-Seq_LS180_Human0.91072559
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90752799
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90300368
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89729308
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89430239
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88943776
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88891282
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88355865
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88018138
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87907052
130SPI1_23547873_ChIP-Seq_NB4_Human0.86958536
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.86213289
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85361251
133* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84400827
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83295864
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83110427
136SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82118990
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81577182
138CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80721810
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79735639
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79487466
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77419541
142TFEB_21752829_ChIP-Seq_HELA_Human0.76564532
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75078341
144BP1_19119308_ChIP-ChIP_Hs578T_Human0.74061013
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71761017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81535943
2MP0008057_abnormal_DNA_replication4.78508600
3MP0010094_abnormal_chromosome_stability4.48233054
4MP0004957_abnormal_blastocyst_morpholog4.30743297
5MP0003111_abnormal_nucleus_morphology3.92964430
6MP0003077_abnormal_cell_cycle3.77347435
7MP0008058_abnormal_DNA_repair3.56696050
8MP0003718_maternal_effect3.56518680
9MP0008877_abnormal_DNA_methylation2.89529547
10MP0008932_abnormal_embryonic_tissue2.74346321
11MP0006292_abnormal_olfactory_placode2.70953856
12MP0008007_abnormal_cellular_replicative2.64713083
13MP0003786_premature_aging2.41808676
14MP0003123_paternal_imprinting2.29908319
15MP0006072_abnormal_retinal_apoptosis2.17111312
16MP0003195_calcinosis2.13696481
17MP0002837_dystrophic_cardiac_calcinosis1.97442088
18MP0009379_abnormal_foot_pigmentation1.95907991
19MP0002396_abnormal_hematopoietic_system1.90506279
20MP0000350_abnormal_cell_proliferation1.85335113
21MP0003941_abnormal_skin_development1.78168601
22MP0008789_abnormal_olfactory_epithelium1.77743226
23MP0003787_abnormal_imprinting1.72925019
24MP0002210_abnormal_sex_determination1.71221921
25MP0001730_embryonic_growth_arrest1.67591054
26MP0003315_abnormal_perineum_morphology1.66145241
27MP0003136_yellow_coat_color1.64012181
28MP0006035_abnormal_mitochondrial_morpho1.62950074
29MP0004147_increased_porphyrin_level1.59618605
30MP0002234_abnormal_pharynx_morphology1.56555809
31MP0001119_abnormal_female_reproductive1.56440668
32MP0003122_maternal_imprinting1.52830944
33MP0003763_abnormal_thymus_physiology1.52413356
34MP0005084_abnormal_gallbladder_morpholo1.52328142
35MP0000490_abnormal_crypts_of1.50841586
36MP0001929_abnormal_gametogenesis1.50179010
37MP0000631_abnormal_neuroendocrine_gland1.45723883
38MP0000653_abnormal_sex_gland1.44506378
39MP0005379_endocrine/exocrine_gland_phen1.43286194
40MP0003880_abnormal_central_pattern1.39094252
41MP0002102_abnormal_ear_morphology1.38760159
42MP0002019_abnormal_tumor_incidence1.38373692
43MP0001188_hyperpigmentation1.37143730
44MP0001145_abnormal_male_reproductive1.36619582
45MP0005253_abnormal_eye_physiology1.34185728
46MP0009697_abnormal_copulation1.33743574
47MP0003121_genomic_imprinting1.33263147
48MP0001697_abnormal_embryo_size1.31920269
49MP0009333_abnormal_splenocyte_physiolog1.31871172
50MP0000313_abnormal_cell_death1.29894920
51MP0002736_abnormal_nociception_after1.29550692
52MP0001764_abnormal_homeostasis1.28274644
53MP0005551_abnormal_eye_electrophysiolog1.27826222
54MP0005499_abnormal_olfactory_system1.27466411
55MP0005394_taste/olfaction_phenotype1.27466411
56MP0003186_abnormal_redox_activity1.27329369
57MP0001672_abnormal_embryogenesis/_devel1.26539327
58MP0005380_embryogenesis_phenotype1.26539327
59MP0005397_hematopoietic_system_phenotyp1.26420377
60MP0001545_abnormal_hematopoietic_system1.26420377
61MP0005645_abnormal_hypothalamus_physiol1.24912253
62MP0004215_abnormal_myocardial_fiber1.22543479
63MP0002085_abnormal_embryonic_tissue1.20803734
64MP0001984_abnormal_olfaction1.19186708
65MP0005075_abnormal_melanosome_morpholog1.17385331
66MP0005389_reproductive_system_phenotype1.16855604
67MP0004142_abnormal_muscle_tone1.14436657
68MP0005646_abnormal_pituitary_gland1.13261618
69MP0005451_abnormal_body_composition1.13192252
70MP0002090_abnormal_vision1.12883235
71MP0008995_early_reproductive_senescence1.11249307
72MP0002080_prenatal_lethality1.11173280
73MP0002160_abnormal_reproductive_system1.08835553
74MP0002254_reproductive_system_inflammat1.08786638
75MP0003699_abnormal_female_reproductive1.07723388
76MP0004808_abnormal_hematopoietic_stem1.06757565
77MP0005395_other_phenotype1.05717197
78MP0001919_abnormal_reproductive_system1.04199086
79MP0002638_abnormal_pupillary_reflex1.03560596
80MP0000689_abnormal_spleen_morphology1.00551785
81MP0003567_abnormal_fetal_cardiomyocyte1.00550553
82MP0005408_hypopigmentation1.00445098
83MP0010307_abnormal_tumor_latency1.00199890
84MP0002398_abnormal_bone_marrow0.99040628
85MP0003984_embryonic_growth_retardation0.96832820
86MP0000703_abnormal_thymus_morphology0.96400672
87MP0002084_abnormal_developmental_patter0.95932217
88MP0001986_abnormal_taste_sensitivity0.95786645
89MP0002088_abnormal_embryonic_growth/wei0.92687446
90MP0002009_preneoplasia0.91328342
91MP0002722_abnormal_immune_system0.91027723
92MP0002132_abnormal_respiratory_system0.90359772
93MP0001485_abnormal_pinna_reflex0.90325284
94MP0000647_abnormal_sebaceous_gland0.89955185
95MP0010352_gastrointestinal_tract_polyps0.89818286
96MP0003119_abnormal_digestive_system0.87759869
97MP0008872_abnormal_physiological_respon0.87524389
98MP0002751_abnormal_autonomic_nervous0.86458373
99MP0002086_abnormal_extraembryonic_tissu0.86331576
100MP0009046_muscle_twitch0.86181282
101MP0004133_heterotaxia0.84846902
102MP0001529_abnormal_vocalization0.84559000
103MP0003646_muscle_fatigue0.83834338
104MP0006276_abnormal_autonomic_nervous0.83450365
105MP0003806_abnormal_nucleotide_metabolis0.83039338
106MP0003890_abnormal_embryonic-extraembry0.82559820
107MP0003011_delayed_dark_adaptation0.82352703
108MP0002249_abnormal_larynx_morphology0.81136380
109MP0000015_abnormal_ear_pigmentation0.81062667
110MP0002822_catalepsy0.80462296
111MP0005671_abnormal_response_to0.79796573
112MP0006036_abnormal_mitochondrial_physio0.79660147
113MP0001324_abnormal_eye_pigmentation0.78571778
114MP0001286_abnormal_eye_development0.78391850
115MP0002233_abnormal_nose_morphology0.77659299
116MP0000427_abnormal_hair_cycle0.76305031
117MP0000566_synostosis0.75880215
118MP0000358_abnormal_cell_content/0.75810112
119MP0000049_abnormal_middle_ear0.74532100
120MP0005391_vision/eye_phenotype0.74006748
121MP0001968_abnormal_touch/_nociception0.72893928
122MP0010030_abnormal_orbit_morphology0.72368631
123MP0002653_abnormal_ependyma_morphology0.72047271
124MP0002429_abnormal_blood_cell0.72038860
125MP0001293_anophthalmia0.71894372
126MP0002161_abnormal_fertility/fecundity0.70770586
127MP0000372_irregular_coat_pigmentation0.69070231
128MP0005410_abnormal_fertilization0.69058065
129MP0000716_abnormal_immune_system0.67850869
130MP0003937_abnormal_limbs/digits/tail_de0.65870808
131MP0001905_abnormal_dopamine_level0.65146674
132MP0002095_abnormal_skin_pigmentation0.64786955
133MP0002938_white_spotting0.64417325
134MP0005187_abnormal_penis_morphology0.62896273
135MP0005195_abnormal_posterior_eye0.62703286
136MP0005384_cellular_phenotype0.62529529
137MP0008260_abnormal_autophagy0.62345973
138MP0002277_abnormal_respiratory_mucosa0.61924254
139MP0004197_abnormal_fetal_growth/weight/0.60887509
140MP0005621_abnormal_cell_physiology0.60259136
141MP0003698_abnormal_male_reproductive0.59988882
142MP0005174_abnormal_tail_pigmentation0.59774395
143MP0003936_abnormal_reproductive_system0.58337991
144MP0005266_abnormal_metabolism0.56205249
145MP0000858_altered_metastatic_potential0.53263246
146MP0002405_respiratory_system_inflammati0.53249590
147MP0002163_abnormal_gland_morphology0.52287929

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.23861572
2Breast hypoplasia (HP:0003187)4.92181440
3Patellar aplasia (HP:0006443)4.02516158
4Chromsome breakage (HP:0040012)3.83157056
5Acute encephalopathy (HP:0006846)3.79756069
6Abnormality of cells of the erythroid lineage (HP:0012130)3.77951927
7Progressive macrocephaly (HP:0004481)3.77378959
8Supernumerary spleens (HP:0009799)3.72356614
9Aplasia/Hypoplasia of the patella (HP:0006498)3.70749994
10Aplastic anemia (HP:0001915)3.67204949
11Abnormal number of erythroid precursors (HP:0012131)3.66199582
12Abnormal mitochondria in muscle tissue (HP:0008316)3.63588075
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61703345
14Carpal bone hypoplasia (HP:0001498)3.48424450
15Reticulocytopenia (HP:0001896)3.44442708
16Lipid accumulation in hepatocytes (HP:0006561)3.42663616
17Abnormality of the preputium (HP:0100587)3.16507834
18Absent radius (HP:0003974)3.15999002
19Oral leukoplakia (HP:0002745)3.06826756
20Meckel diverticulum (HP:0002245)3.02474326
21Renal Fanconi syndrome (HP:0001994)3.00017783
22Abnormality of the labia minora (HP:0012880)2.99590783
23Absent forearm bone (HP:0003953)2.97589841
24Aplasia involving forearm bones (HP:0009822)2.97589841
25Abnormality of the ileum (HP:0001549)2.96416294
26Hepatic necrosis (HP:0002605)2.95523470
27Pancreatic fibrosis (HP:0100732)2.90748137
28Premature ovarian failure (HP:0008209)2.90697998
29Methylmalonic acidemia (HP:0002912)2.90367353
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.88261806
31Rough bone trabeculation (HP:0100670)2.79204051
32Absent thumb (HP:0009777)2.78205048
33Cerebral edema (HP:0002181)2.75617756
34Abnormality of chromosome stability (HP:0003220)2.75007216
35Impulsivity (HP:0100710)2.73503886
36Secondary amenorrhea (HP:0000869)2.70144085
37Septo-optic dysplasia (HP:0100842)2.64341084
38Degeneration of anterior horn cells (HP:0002398)2.59517486
39Abnormality of the anterior horn cell (HP:0006802)2.59517486
40Myelodysplasia (HP:0002863)2.58403520
41Microretrognathia (HP:0000308)2.57561198
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.55727436
43Pancreatic cysts (HP:0001737)2.54535187
44Horseshoe kidney (HP:0000085)2.53045791
45Macrocytic anemia (HP:0001972)2.51987257
46Cerebral hypomyelination (HP:0006808)2.48258289
47Methylmalonic aciduria (HP:0012120)2.45591765
48Type 2 muscle fiber atrophy (HP:0003554)2.39910433
49Exertional dyspnea (HP:0002875)2.39592540
50Premature graying of hair (HP:0002216)2.39525194
51Small intestinal stenosis (HP:0012848)2.37889260
52Duodenal stenosis (HP:0100867)2.37889260
53Medial flaring of the eyebrow (HP:0010747)2.37034370
54Bone marrow hypocellularity (HP:0005528)2.36551466
55Muscle fiber atrophy (HP:0100295)2.36491309
56Pallor (HP:0000980)2.35802731
57Cleft eyelid (HP:0000625)2.34681048
58Hyperglycinemia (HP:0002154)2.33601704
59Nephronophthisis (HP:0000090)2.33253674
60Molar tooth sign on MRI (HP:0002419)2.32166136
61Abnormality of midbrain morphology (HP:0002418)2.32166136
62Selective tooth agenesis (HP:0001592)2.31515036
63Triphalangeal thumb (HP:0001199)2.29584487
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26581768
65Facial hemangioma (HP:0000329)2.25300400
66Lactic acidosis (HP:0003128)2.24652368
67Colon cancer (HP:0003003)2.22984776
68Abnormal lung lobation (HP:0002101)2.22535385
69Sloping forehead (HP:0000340)2.21753646
70Absent septum pellucidum (HP:0001331)2.18848231
71Abnormality of the columella (HP:0009929)2.18576641
72Capillary hemangiomas (HP:0005306)2.18166585
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17217036
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17217036
75Type I transferrin isoform profile (HP:0003642)2.16960091
76Hyperinsulinemic hypoglycemia (HP:0000825)2.15940718
77True hermaphroditism (HP:0010459)2.15553716
783-Methylglutaconic aciduria (HP:0003535)2.12490845
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12403326
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11841723
81Abnormality of methionine metabolism (HP:0010901)2.11714239
82Optic disc pallor (HP:0000543)2.08027162
83CNS hypomyelination (HP:0003429)2.07739679
84Respiratory failure (HP:0002878)2.07124742
85Exercise intolerance (HP:0003546)2.07055307
86Intestinal atresia (HP:0011100)2.06905385
87Irregular epiphyses (HP:0010582)2.05659802
88Increased intramyocellular lipid droplets (HP:0012240)2.05527118
89Pendular nystagmus (HP:0012043)2.05497993
9011 pairs of ribs (HP:0000878)2.04965772
91Abnormal trabecular bone morphology (HP:0100671)2.03961034
92Pulmonary fibrosis (HP:0002206)2.03529906
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02835259
94Respiratory difficulties (HP:0002880)2.02474932
95Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02144653
96Hypothermia (HP:0002045)2.00951746
97Sparse eyelashes (HP:0000653)2.00677553
98Optic nerve coloboma (HP:0000588)2.00424024
99Clubbing of toes (HP:0100760)2.00408806
100Cellular immunodeficiency (HP:0005374)1.98603102
101Shawl scrotum (HP:0000049)1.98201953
102Abnormality of the duodenum (HP:0002246)1.98066664
103Stenosis of the external auditory canal (HP:0000402)1.97242936
104Glycosuria (HP:0003076)1.96654440
105Abnormality of urine glucose concentration (HP:0011016)1.96654440
106Abnormality of the septum pellucidum (HP:0007375)1.96526552
107Optic nerve hypoplasia (HP:0000609)1.96520773
108Increased hepatocellular lipid droplets (HP:0006565)1.96421025
109Short thumb (HP:0009778)1.96264063
110Hepatocellular necrosis (HP:0001404)1.95581856
111Hypoplasia of the radius (HP:0002984)1.95341280
112Male infertility (HP:0003251)1.95273623
113Breast aplasia (HP:0100783)1.94835379
114Acute necrotizing encephalopathy (HP:0006965)1.94818582
115Abnormal spermatogenesis (HP:0008669)1.94611037
116Abnormality of serum amino acid levels (HP:0003112)1.94506956
117Abnormality of renal resorption (HP:0011038)1.93234706
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92901808
119Abnormality of vitamin B metabolism (HP:0004340)1.92537748
120Congenital primary aphakia (HP:0007707)1.92304185
121Mitochondrial inheritance (HP:0001427)1.92217133
122Lethargy (HP:0001254)1.92190301
123Hypoglycemic coma (HP:0001325)1.91920562
124Hypoglycemic seizures (HP:0002173)1.91293347
125Median cleft lip (HP:0000161)1.90908406
126Volvulus (HP:0002580)1.90257770
127Pancytopenia (HP:0001876)1.90046648
128Rhabdomyosarcoma (HP:0002859)1.89669490
129Nephroblastoma (Wilms tumor) (HP:0002667)1.89298550
130Medulloblastoma (HP:0002885)1.88963502
131Genital tract atresia (HP:0001827)1.87946595
132Congenital, generalized hypertrichosis (HP:0004540)1.86413004
133Aplasia/Hypoplasia of the breasts (HP:0010311)1.85383429
134Gait imbalance (HP:0002141)1.84746598
135Increased CSF lactate (HP:0002490)1.83556858
136Leukodystrophy (HP:0002415)1.82936711
137Abnormality of the renal medulla (HP:0100957)1.81899669
138Tracheoesophageal fistula (HP:0002575)1.81890666
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.79622841
140Pancreatic islet-cell hyperplasia (HP:0004510)1.79004721
141Hyperglycinuria (HP:0003108)1.78270594
142Abnormality of serine family amino acid metabolism (HP:0010894)1.78099836
143Abnormality of glycine metabolism (HP:0010895)1.78099836
144Rectal fistula (HP:0100590)1.77649227
145Rectovaginal fistula (HP:0000143)1.77649227
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77613345
147Nephrogenic diabetes insipidus (HP:0009806)1.77380600
148Increased serum lactate (HP:0002151)1.77356377
149Duplicated collecting system (HP:0000081)1.76299385
150Abnormality of the fovea (HP:0000493)1.75163445
151Vaginal atresia (HP:0000148)1.74737646
152Ectopic kidney (HP:0000086)1.73921363
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73395649
154Embryonal renal neoplasm (HP:0011794)1.73258340
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.73166353
156Aplasia/hypoplasia of the uterus (HP:0008684)1.71940836
157Bile duct proliferation (HP:0001408)1.71162612
158Abnormal biliary tract physiology (HP:0012439)1.71162612
159Abnormal hair whorl (HP:0010721)1.70406683
160Abnormality of alanine metabolism (HP:0010916)1.70325659
161Hyperalaninemia (HP:0003348)1.70325659
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70325659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.12101864
2BUB13.68161973
3EIF2AK13.63654816
4CDC73.49237658
5PLK43.43438325
6SRPK13.10581019
7MKNK22.86755585
8VRK22.70315492
9TTK2.60242503
10TRIM282.57675437
11WNK32.50551855
12NUAK12.41273170
13MKNK12.40815356
14VRK12.39744387
15STK162.36897754
16NME22.20823403
17BMPR1B2.17393521
18BRSK22.16319865
19PLK12.14432759
20FRK2.09990083
21NEK22.04801492
22EIF2AK32.01833263
23MAP4K21.99183663
24MAP3K61.86319642
25DYRK31.83981559
26CDK71.79127268
27ACVR1B1.78301355
28TAF11.74397481
29TESK21.66977488
30ERBB31.59522103
31BRAF1.52542115
32PLK31.51008724
33CHEK21.50835710
34CDK81.49111861
35AURKB1.48284917
36ATR1.41353455
37STK38L1.36751959
38MUSK1.31754669
39LATS21.28611396
40PIM21.27991401
41AURKA1.26906022
42RPS6KB21.25257286
43GRK11.24802014
44DYRK21.21611776
45BCR1.13689085
46TSSK61.12521673
47STK101.10657945
48RPS6KA41.08086050
49EIF2AK21.08039944
50MAP3K81.07469423
51CCNB11.04755728
52BRSK11.04311042
53CASK1.02905006
54MAP3K41.00508391
55CSNK1G20.96589968
56NLK0.95735096
57NEK10.91196150
58MOS0.90723798
59MAPKAPK30.88565807
60CHEK10.88500653
61PASK0.84666679
62ZAK0.81625728
63PIM10.80304825
64CDK40.79190056
65STK390.78467624
66TLK10.78373109
67CSNK2A10.76974702
68MAPK130.76640895
69PDK20.75591401
70ATM0.75500675
71BMPR20.74065861
72ARAF0.72607786
73NME10.72104159
74RAF10.71779031
75AKT30.70256632
76MST40.70064184
77TEC0.69316395
78OXSR10.66267486
79ABL20.65794103
80CSNK2A20.65509973
81PRKCG0.62000704
82MELK0.61935615
83PINK10.61219646
84STK240.61096256
85BCKDK0.60774872
86EPHA20.60293178
87CDK20.60105650
88SIK30.59680295
89TXK0.58341797
90NEK60.57983217
91STK40.57224188
92PBK0.57118411
93TAOK30.56808650
94STK30.56661705
95WNK40.56427877
96PRKCE0.55518016
97EPHA40.54606878
98IRAK30.54598351
99PAK30.53230313
100CSNK1A10.51326347
101CDK30.50056559
102MAP4K10.49585505
103INSRR0.49579557
104CDK10.49330881
105PRKCI0.48909728
106ERBB40.46865050
107PLK20.45450909
108CDK190.44176332
109YES10.43628114
110CSNK1E0.42754224
111FGFR20.42075686
112KIT0.42011524
113TGFBR10.41659885
114CSNK1A1L0.41478925
115RPS6KA50.40237675
116IRAK40.40082140
117CSNK1G30.40066651
118PNCK0.39956873
119CSNK1G10.39515381
120CDK120.39459882
121MAP3K110.39272592
122BRD40.39040057
123KDR0.38662138
124PAK10.38436330
125MAP2K70.36683929
126OBSCN0.33923070
127MARK30.33686925
128MAP3K120.32568032
129MATK0.32072517
130MAPKAPK50.30882071
131PKN10.30472309
132PRKG10.29798610
133ADRBK20.29755413
134TIE10.29747663
135TNIK0.28999588
136LATS10.27571902
137ALK0.24848123
138PRKACB0.24838533
139PRKCQ0.24577775
140PRKDC0.24300488

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40776038
2RNA polymerase_Homo sapiens_hsa030204.08529205
3Ribosome_Homo sapiens_hsa030103.90183506
4Mismatch repair_Homo sapiens_hsa034303.89228510
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87899431
6Proteasome_Homo sapiens_hsa030503.36879960
7Homologous recombination_Homo sapiens_hsa034403.28771736
8Spliceosome_Homo sapiens_hsa030403.09774792
9RNA transport_Homo sapiens_hsa030133.00517955
10Nucleotide excision repair_Homo sapiens_hsa034202.87658015
11Base excision repair_Homo sapiens_hsa034102.86125129
12Basal transcription factors_Homo sapiens_hsa030222.79999107
13Cell cycle_Homo sapiens_hsa041102.69138099
14Pyrimidine metabolism_Homo sapiens_hsa002402.69129083
15Fanconi anemia pathway_Homo sapiens_hsa034602.64779356
16RNA degradation_Homo sapiens_hsa030182.48558447
17Non-homologous end-joining_Homo sapiens_hsa034502.13551211
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11792919
19p53 signaling pathway_Homo sapiens_hsa041151.80007686
20Propanoate metabolism_Homo sapiens_hsa006401.63953989
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61896177
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61049421
23Purine metabolism_Homo sapiens_hsa002301.59865292
24Protein export_Homo sapiens_hsa030601.58800862
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57529979
26One carbon pool by folate_Homo sapiens_hsa006701.49670958
27Steroid biosynthesis_Homo sapiens_hsa001001.39883746
28mRNA surveillance pathway_Homo sapiens_hsa030151.39201678
29Fatty acid elongation_Homo sapiens_hsa000621.35823756
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31413515
31Huntingtons disease_Homo sapiens_hsa050161.26609684
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.20935888
33Sulfur metabolism_Homo sapiens_hsa009201.15582028
34Butanoate metabolism_Homo sapiens_hsa006501.15575462
35Epstein-Barr virus infection_Homo sapiens_hsa051691.14622892
36Oxidative phosphorylation_Homo sapiens_hsa001901.14103403
37Phototransduction_Homo sapiens_hsa047441.11864833
38Parkinsons disease_Homo sapiens_hsa050121.09858501
39Vitamin B6 metabolism_Homo sapiens_hsa007501.08130388
40Cardiac muscle contraction_Homo sapiens_hsa042601.06257210
41Folate biosynthesis_Homo sapiens_hsa007901.02894676
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01666160
43Oocyte meiosis_Homo sapiens_hsa041140.99605226
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99407474
45Peroxisome_Homo sapiens_hsa041460.96006851
46Herpes simplex infection_Homo sapiens_hsa051680.93479603
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89423373
48Pyruvate metabolism_Homo sapiens_hsa006200.86771887
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80302959
50Tryptophan metabolism_Homo sapiens_hsa003800.76851304
51Collecting duct acid secretion_Homo sapiens_hsa049660.75961207
52Caffeine metabolism_Homo sapiens_hsa002320.73200760
53Sulfur relay system_Homo sapiens_hsa041220.71646354
54Arachidonic acid metabolism_Homo sapiens_hsa005900.71283847
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71116844
56Thyroid cancer_Homo sapiens_hsa052160.68817272
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.67730064
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65985840
59Primary immunodeficiency_Homo sapiens_hsa053400.64756510
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63444370
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62215956
62Hematopoietic cell lineage_Homo sapiens_hsa046400.58157082
63Antigen processing and presentation_Homo sapiens_hsa046120.58133063
64Glutathione metabolism_Homo sapiens_hsa004800.57391748
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56564822
66Nitrogen metabolism_Homo sapiens_hsa009100.55977654
67Regulation of autophagy_Homo sapiens_hsa041400.53524621
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52363360
69TGF-beta signaling pathway_Homo sapiens_hsa043500.50444869
70Alzheimers disease_Homo sapiens_hsa050100.49786407
71Linoleic acid metabolism_Homo sapiens_hsa005910.48411802
72Pentose phosphate pathway_Homo sapiens_hsa000300.48391293
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.48355725
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47645860
75Retinol metabolism_Homo sapiens_hsa008300.47554423
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45885855
77Circadian rhythm_Homo sapiens_hsa047100.44745815
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44726767
79Viral carcinogenesis_Homo sapiens_hsa052030.44534599
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42237610
81HTLV-I infection_Homo sapiens_hsa051660.41950376
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41706893
83Allograft rejection_Homo sapiens_hsa053300.41132220
84Chemical carcinogenesis_Homo sapiens_hsa052040.41081283
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39414521
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.38668801
87MicroRNAs in cancer_Homo sapiens_hsa052060.37205713
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37179271
89beta-Alanine metabolism_Homo sapiens_hsa004100.36449905
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36040030
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.35659523
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35553613
93Measles_Homo sapiens_hsa051620.35367596
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.35014158
95Nicotine addiction_Homo sapiens_hsa050330.34779242
96Olfactory transduction_Homo sapiens_hsa047400.34545769
97Metabolic pathways_Homo sapiens_hsa011000.34539629
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34429825
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33809669
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.32757432
101Hedgehog signaling pathway_Homo sapiens_hsa043400.32653967
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32269644
103Vitamin digestion and absorption_Homo sapiens_hsa049770.32032330
104Graft-versus-host disease_Homo sapiens_hsa053320.31259649
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30912294
106Fatty acid degradation_Homo sapiens_hsa000710.30887086
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.28879096
108Hepatitis B_Homo sapiens_hsa051610.28653265
109Systemic lupus erythematosus_Homo sapiens_hsa053220.28254294
110Asthma_Homo sapiens_hsa053100.28231676
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27203069
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26901962
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26082590
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25920008
115Legionellosis_Homo sapiens_hsa051340.25099335
116Fatty acid metabolism_Homo sapiens_hsa012120.24712837
117Shigellosis_Homo sapiens_hsa051310.23457762
118Other glycan degradation_Homo sapiens_hsa005110.23075804
119Ether lipid metabolism_Homo sapiens_hsa005650.21899814
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21638260
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21166212
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20481955
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.20208013
124Autoimmune thyroid disease_Homo sapiens_hsa053200.19944669
125Sphingolipid metabolism_Homo sapiens_hsa006000.19315779
126Carbon metabolism_Homo sapiens_hsa012000.18998537
127Apoptosis_Homo sapiens_hsa042100.18304348
128Taste transduction_Homo sapiens_hsa047420.18105917
129Influenza A_Homo sapiens_hsa051640.17731611
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17709605
131Fructose and mannose metabolism_Homo sapiens_hsa000510.17546361
132Serotonergic synapse_Homo sapiens_hsa047260.17442783
133Small cell lung cancer_Homo sapiens_hsa052220.17430997
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16680568
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15604569
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15221497
137Colorectal cancer_Homo sapiens_hsa052100.13507079
138Biosynthesis of amino acids_Homo sapiens_hsa012300.12644186
139HIF-1 signaling pathway_Homo sapiens_hsa040660.11175001
140Ovarian steroidogenesis_Homo sapiens_hsa049130.10368782
141Notch signaling pathway_Homo sapiens_hsa043300.09920915
142Pathways in cancer_Homo sapiens_hsa052000.09851408
143Selenocompound metabolism_Homo sapiens_hsa004500.09212754
144Arginine and proline metabolism_Homo sapiens_hsa003300.07181853
145Hippo signaling pathway_Homo sapiens_hsa043900.05367099

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