ZCCHC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.44678899
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.91826440
3neural tube formation (GO:0001841)4.57145325
4nuclear pore complex assembly (GO:0051292)4.33251919
5pyrimidine nucleobase catabolic process (GO:0006208)3.97248321
6nuclear pore organization (GO:0006999)3.97131742
7negative regulation of histone methylation (GO:0031061)3.96139070
8regulation of DNA endoreduplication (GO:0032875)3.95704166
9limb bud formation (GO:0060174)3.83291858
10negative regulation of cytosolic calcium ion concentration (GO:0051481)3.79754897
11regulation of RNA export from nucleus (GO:0046831)3.67700725
12DNA unwinding involved in DNA replication (GO:0006268)3.66161534
13regulation of timing of cell differentiation (GO:0048505)3.63470500
14alternative mRNA splicing, via spliceosome (GO:0000380)3.61041574
15* pre-miRNA processing (GO:0031054)3.60771136
16regulation of histone H3-K9 methylation (GO:0051570)3.51972582
17regulation of development, heterochronic (GO:0040034)3.45293614
18DNA topological change (GO:0006265)3.44223959
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43441294
20mRNA splice site selection (GO:0006376)3.41519853
21negative regulation of RNA splicing (GO:0033119)3.39613244
22spinal cord motor neuron differentiation (GO:0021522)3.37013955
23behavioral response to nicotine (GO:0035095)3.35763985
24definitive hemopoiesis (GO:0060216)3.35388054
25cytoplasmic mRNA processing body assembly (GO:0033962)3.35334697
26histone H3-K4 trimethylation (GO:0080182)3.34485307
27microtubule anchoring (GO:0034453)3.31623123
28nonmotile primary cilium assembly (GO:0035058)3.26979842
29glucocorticoid receptor signaling pathway (GO:0042921)3.25750196
30negative regulation of cell killing (GO:0031342)3.24097811
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24097811
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22728526
33negative regulation of DNA repair (GO:0045738)3.21976529
34negative regulation of mRNA processing (GO:0050686)3.19553095
35pore complex assembly (GO:0046931)3.18201836
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.17618391
37regulation of translation, ncRNA-mediated (GO:0045974)3.17618391
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17618391
39mRNA stabilization (GO:0048255)3.17109332
40RNA stabilization (GO:0043489)3.17109332
41somite development (GO:0061053)3.14408905
42peptidyl-lysine trimethylation (GO:0018023)3.11865664
43positive regulation of gamma-delta T cell activation (GO:0046645)3.11676926
44dosage compensation (GO:0007549)3.11550560
45presynaptic membrane assembly (GO:0097105)3.10775742
46intraciliary transport (GO:0042073)3.09152379
47forebrain neuron differentiation (GO:0021879)3.07812467
48DNA geometric change (GO:0032392)3.06752704
49nucleobase catabolic process (GO:0046113)3.05607387
50histone H3-K4 methylation (GO:0051568)3.05525983
51DNA duplex unwinding (GO:0032508)3.05125885
52hindbrain development (GO:0030902)3.04127280
53histone H3-K9 methylation (GO:0051567)3.03821575
54cell differentiation in spinal cord (GO:0021515)3.03364181
55retinal ganglion cell axon guidance (GO:0031290)3.00961120
56response to pheromone (GO:0019236)3.00907203
57histone H3-K36 demethylation (GO:0070544)2.99754364
58negative regulation of mRNA metabolic process (GO:1903312)2.98253101
59kidney morphogenesis (GO:0060993)2.97978198
60V(D)J recombination (GO:0033151)2.97416995
61kinetochore organization (GO:0051383)2.95055209
62regulation of sister chromatid cohesion (GO:0007063)2.94022144
63establishment of protein localization to Golgi (GO:0072600)2.92565695
64cornea development in camera-type eye (GO:0061303)2.92267485
65centriole replication (GO:0007099)2.92157658
66olfactory bulb development (GO:0021772)2.90587315
67tryptophan catabolic process (GO:0006569)2.90332114
68indole-containing compound catabolic process (GO:0042436)2.90332114
69indolalkylamine catabolic process (GO:0046218)2.90332114
70protein K11-linked deubiquitination (GO:0035871)2.90015373
71central nervous system projection neuron axonogenesis (GO:0021952)2.89789955
72sister chromatid cohesion (GO:0007062)2.89115927
73phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88970083
74dendritic spine morphogenesis (GO:0060997)2.87646099
75protein polyglutamylation (GO:0018095)2.87614130
76nucleosome disassembly (GO:0006337)2.85328769
77protein-DNA complex disassembly (GO:0032986)2.85328769
78positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.84619272
79sister chromatid segregation (GO:0000819)2.84568966
80interkinetic nuclear migration (GO:0022027)2.83841383
81microtubule polymerization or depolymerization (GO:0031109)2.83395074
82histone lysine methylation (GO:0034968)2.82881777
83mitotic chromosome condensation (GO:0007076)2.82733040
84regulation of histone methylation (GO:0031060)2.81893700
85head development (GO:0060322)2.81803376
86B cell receptor signaling pathway (GO:0050853)2.81565124
87spinal cord development (GO:0021510)2.80540483
88regulation of telomere maintenance (GO:0032204)2.79719388
89negative regulation of histone modification (GO:0031057)2.79628898
90regulation of gamma-delta T cell differentiation (GO:0045586)2.78142759
91translesion synthesis (GO:0019985)2.77873784
92positive regulation of gene expression, epigenetic (GO:0045815)2.77634254
93regulation of nucleobase-containing compound transport (GO:0032239)2.76730951
94positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76504345
95regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76504345
96regulation of mRNA stability (GO:0043488)2.76060798
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.75968058
98mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.75795054
99positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.75795054
100central nervous system neuron axonogenesis (GO:0021955)2.75563858
101regulation of histone H3-K4 methylation (GO:0051569)2.74092966
102negative regulation of chromatin modification (GO:1903309)2.73873579
103replication fork processing (GO:0031297)2.73193701
104presynaptic membrane organization (GO:0097090)2.72525455
105protein localization to kinetochore (GO:0034501)2.71478231
106dorsal/ventral axis specification (GO:0009950)2.71395802
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71049659
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71049659
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.71049659
110cell proliferation in forebrain (GO:0021846)2.68463044
111cilium organization (GO:0044782)2.64289522
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64261562
113cilium assembly (GO:0042384)2.63549484
114positive regulation by host of viral transcription (GO:0043923)2.63053809
115histone H3-K9 modification (GO:0061647)2.62653438
116ATP-dependent chromatin remodeling (GO:0043044)2.61809977
117monoubiquitinated protein deubiquitination (GO:0035520)2.61782022
118positive regulation of mRNA catabolic process (GO:0061014)2.61255090
119detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60678049
120corticosteroid receptor signaling pathway (GO:0031958)2.60597076
121otic vesicle formation (GO:0030916)2.58542189
122histone H2A acetylation (GO:0043968)2.58369159
123positive thymic T cell selection (GO:0045059)2.58205503
124single strand break repair (GO:0000012)2.57650625
125histone lysine demethylation (GO:0070076)2.56646953
126cilium morphogenesis (GO:0060271)2.56497585
127DNA conformation change (GO:0071103)2.55714179
128protein localization to chromosome, centromeric region (GO:0071459)2.55586853
129regulation of RNA stability (GO:0043487)2.55464882
130chromatin assembly (GO:0031497)2.54229142
131reciprocal DNA recombination (GO:0035825)2.54219121
132reciprocal meiotic recombination (GO:0007131)2.54219121
133protein targeting to Golgi (GO:0000042)2.53602584
134histone H3-K9 demethylation (GO:0033169)2.53480617
135inositol phosphate catabolic process (GO:0071545)2.53325507
136nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52700675
137indolalkylamine metabolic process (GO:0006586)2.51094006
138neuronal stem cell maintenance (GO:0097150)2.50833478
139regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.50685642
140positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.50685642
141photoreceptor cell maintenance (GO:0045494)2.50649500
142positive T cell selection (GO:0043368)2.50400196
143sympathetic nervous system development (GO:0048485)2.50233825
144positive regulation of histone H3-K4 methylation (GO:0051571)2.49836670
145peptidyl-lysine methylation (GO:0018022)2.49142815
146neuron recognition (GO:0008038)2.48812732
147regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.48248574
148histone demethylation (GO:0016577)2.47901515
149regulation of gamma-delta T cell activation (GO:0046643)2.47140579
150appendage development (GO:0048736)2.47132696
151limb development (GO:0060173)2.47132696
152intra-S DNA damage checkpoint (GO:0031573)2.46954376
153histone H4-K16 acetylation (GO:0043984)2.46565253
154piRNA metabolic process (GO:0034587)2.46239800
155chromatin assembly or disassembly (GO:0006333)2.46017334
156axoneme assembly (GO:0035082)2.45483995
157pancreas development (GO:0031016)2.44426050
158regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44286718
159mRNA export from nucleus (GO:0006406)2.44043485
160resolution of meiotic recombination intermediates (GO:0000712)2.44019198
161cerebral cortex radially oriented cell migration (GO:0021799)2.43528941
162gene silencing by RNA (GO:0031047)2.43504674
163nucleus localization (GO:0051647)2.43475167
164detection of light stimulus involved in sensory perception (GO:0050962)2.42970844
165detection of light stimulus involved in visual perception (GO:0050908)2.42970844
166protein localization to synapse (GO:0035418)2.42848600
167regulation of cilium movement (GO:0003352)2.42812403
168embryonic epithelial tube formation (GO:0001838)2.42718353
169negative regulation of DNA recombination (GO:0045910)2.42689684
170regulation of collateral sprouting (GO:0048670)2.42459087
171regulation of stem cell maintenance (GO:2000036)2.42389787
172DNA replication-independent nucleosome assembly (GO:0006336)2.42276425
173DNA replication-independent nucleosome organization (GO:0034724)2.42276425
174kynurenine metabolic process (GO:0070189)2.41940819
175embryonic hemopoiesis (GO:0035162)2.41590436
176axonal fasciculation (GO:0007413)2.40902237
177gastrulation with mouth forming second (GO:0001702)2.40284002
178recombinational repair (GO:0000725)2.40148226
179tryptophan metabolic process (GO:0006568)2.39903385
180establishment of mitochondrion localization (GO:0051654)2.39792402
181double-strand break repair via homologous recombination (GO:0000724)2.38783432
182vascular smooth muscle contraction (GO:0014829)2.38234455
183histone-serine phosphorylation (GO:0035404)2.37802093
184gamma-aminobutyric acid transport (GO:0015812)2.37750564
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37531428
186postsynaptic membrane organization (GO:0001941)2.36962511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.75950506
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92418917
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.92195439
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.83899519
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76989907
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.56753626
7IGF1R_20145208_ChIP-Seq_DFB_Human3.54442327
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38975170
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.38776845
10EZH2_22144423_ChIP-Seq_EOC_Human3.29172147
11MYC_22102868_ChIP-Seq_BL_Human3.19636962
12ZNF274_21170338_ChIP-Seq_K562_Hela2.99433649
13GBX2_23144817_ChIP-Seq_PC3_Human2.97529824
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96131944
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94861535
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85051046
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71106261
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67515208
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64919218
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36284850
21CIITA_25753668_ChIP-Seq_RAJI_Human2.34413150
22VDR_22108803_ChIP-Seq_LS180_Human2.28676450
23TAF15_26573619_Chip-Seq_HEK293_Human2.24508114
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.23048065
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.18388499
26SCL_19346495_ChIP-Seq_HPC-7_Human2.14246369
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13459574
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08156806
29P300_19829295_ChIP-Seq_ESCs_Human2.03850343
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03225116
31E2F7_22180533_ChIP-Seq_HELA_Human10.3576514
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99908253
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94863929
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94755867
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92239411
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.86542099
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.86250030
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.85039165
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83582438
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82446006
41TCF7_22412390_ChIP-Seq_EML_Mouse1.80947327
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.79374060
43SMAD4_21799915_ChIP-Seq_A2780_Human1.75700825
44* STAT3_23295773_ChIP-Seq_U87_Human1.72034380
45* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69684594
46* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69684594
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.68753606
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68632977
49* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64700846
50MYB_26560356_Chip-Seq_TH1_Human1.62682798
51MYB_26560356_Chip-Seq_TH2_Human1.60426645
52ER_23166858_ChIP-Seq_MCF-7_Human1.58914099
53RUNX_20019798_ChIP-Seq_JUKART_Human1.58903677
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.58059040
55PKCTHETA_26484144_Chip-Seq_BREAST_Human1.57639206
56RNF2_27304074_Chip-Seq_NSC_Mouse1.57588013
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56358795
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55586020
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55466365
60CBP_20019798_ChIP-Seq_JUKART_Human1.55466365
61TCF4_23295773_ChIP-Seq_U87_Human1.54883370
62* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53040144
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.51932226
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51151835
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51020219
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47667970
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46267932
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46158728
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44359721
70VDR_21846776_ChIP-Seq_THP-1_Human1.44092436
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41347039
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41302708
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41257863
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40781758
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39856719
76AR_21572438_ChIP-Seq_LNCaP_Human1.38781154
77BCAT_22108803_ChIP-Seq_LS180_Human1.38309549
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.37165188
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37089587
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36999759
81IRF1_19129219_ChIP-ChIP_H3396_Human1.35515676
82UTX_26944678_Chip-Seq_JUKART_Human1.35282036
83EWS_26573619_Chip-Seq_HEK293_Human1.35132892
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34856284
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34666514
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33061155
87RUNX2_22187159_ChIP-Seq_PCA_Human1.32357409
88* MAF_26560356_Chip-Seq_TH1_Human1.32104334
89AR_25329375_ChIP-Seq_VCAP_Human1.31831885
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29922148
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28625118
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26141944
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25330847
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25123464
95* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23449141
96REST_21632747_ChIP-Seq_MESCs_Mouse1.22549193
97TP53_16413492_ChIP-PET_HCT116_Human1.21893484
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20569931
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.20474619
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19599692
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19528969
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18250101
103FUS_26573619_Chip-Seq_HEK293_Human1.17957666
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17706954
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.17420088
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17342076
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16844269
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16836686
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15137535
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.14302875
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12484807
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11816829
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.11766747
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11375515
115ELK1_19687146_ChIP-ChIP_HELA_Human1.11169916
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11022330
117* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09990650
118KDM2B_26808549_Chip-Seq_DND41_Human1.09328452
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08855288
120TP53_22573176_ChIP-Seq_HFKS_Human1.08656617
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.08076026
122KDM5A_27292631_Chip-Seq_BREAST_Human1.06704923
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06430209
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05194015
125MYC_18940864_ChIP-ChIP_HL60_Human1.04317291
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04152257
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.04054560
128SOX9_26525672_Chip-Seq_HEART_Mouse1.03949669
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03366765
130TCF4_22108803_ChIP-Seq_LS180_Human1.02638413
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02555152
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01829752
133GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01518863
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01516938
135* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01246009
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01032984
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00667330
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00620926
139KDM2B_26808549_Chip-Seq_REH_Human1.00359594
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00215343
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.99480428
142SPI1_23547873_ChIP-Seq_NB4_Human0.98938230
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98752903
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98381552
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98040965
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97911625
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.97530497
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.97443828
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.97354114
150* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97134548
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97080293
152VDR_24763502_ChIP-Seq_THP-1_Human0.96438556
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94484524
154GATA1_22025678_ChIP-Seq_K562_Human0.94357885
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93808506
156NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93726793
157MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93144019
158FOXP3_21729870_ChIP-Seq_TREG_Human0.91310578
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91163395
160MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90865883
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.90455696
162MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90129734
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.88443423
164* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87860233
165* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86993750
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86331806
167STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84888701
168EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84869376
169SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84728939
170CHD1_26751641_Chip-Seq_LNCaP_Human0.83737053
171VDR_23849224_ChIP-Seq_CD4+_Human0.83226992
172GATA3_27048872_Chip-Seq_THYMUS_Human0.82652717
173SMAD_19615063_ChIP-ChIP_OVARY_Human0.82279800
174AR_21909140_ChIP-Seq_LNCAP_Human0.81586693
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81558347
176STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80605355
177RUNX1_22412390_ChIP-Seq_EML_Mouse0.80603609
178* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79813309
179ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79599965
180BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79104428
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.78603138
182FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78260789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.57711811
2MP0000569_abnormal_digit_pigmentation3.41754028
3MP0003121_genomic_imprinting3.25455979
4MP0008057_abnormal_DNA_replication3.23165689
5MP0003787_abnormal_imprinting2.99133073
6MP0010094_abnormal_chromosome_stability2.76754776
7MP0003122_maternal_imprinting2.69123400
8MP0002009_preneoplasia2.53469559
9MP0003123_paternal_imprinting2.46995472
10MP0002396_abnormal_hematopoietic_system2.34037649
11MP0005423_abnormal_somatic_nervous2.30692283
12MP0005394_taste/olfaction_phenotype2.25746707
13MP0005499_abnormal_olfactory_system2.25746707
14MP0002102_abnormal_ear_morphology2.24421314
15MP0003077_abnormal_cell_cycle2.23201894
16MP0002638_abnormal_pupillary_reflex2.20929678
17MP0004133_heterotaxia2.20076958
18MP0008789_abnormal_olfactory_epithelium2.19800789
19MP0003567_abnormal_fetal_cardiomyocyte2.19095123
20MP0004808_abnormal_hematopoietic_stem2.15549881
21MP0008877_abnormal_DNA_methylation2.11106300
22MP0000778_abnormal_nervous_system2.08415578
23MP0003111_abnormal_nucleus_morphology2.07562247
24MP0008007_abnormal_cellular_replicative2.03545065
25MP0002166_altered_tumor_susceptibility2.02899684
26MP0003763_abnormal_thymus_physiology1.97611075
27MP0003890_abnormal_embryonic-extraembry1.88822112
28MP0008058_abnormal_DNA_repair1.86440223
29MP0005076_abnormal_cell_differentiation1.82436379
30MP0003693_abnormal_embryo_hatching1.78093978
31MP0000631_abnormal_neuroendocrine_gland1.75483807
32MP0005551_abnormal_eye_electrophysiolog1.75192163
33MP0000703_abnormal_thymus_morphology1.69374582
34MP0001800_abnormal_humoral_immune1.66822995
35MP0006276_abnormal_autonomic_nervous1.60359897
36MP0001984_abnormal_olfaction1.60019322
37MP0010352_gastrointestinal_tract_polyps1.57663980
38MP0002398_abnormal_bone_marrow1.55578406
39MP0004197_abnormal_fetal_growth/weight/1.53701171
40MP0006072_abnormal_retinal_apoptosis1.53197876
41MP0002006_tumorigenesis1.46629346
42MP0003943_abnormal_hepatobiliary_system1.46607192
43MP0003646_muscle_fatigue1.44590220
44MP0006054_spinal_hemorrhage1.44288820
45MP0004957_abnormal_blastocyst_morpholog1.44159518
46MP0005174_abnormal_tail_pigmentation1.44008540
47MP0008995_early_reproductive_senescence1.43067645
48MP0002088_abnormal_embryonic_growth/wei1.41905293
49MP0005671_abnormal_response_to1.40624057
50MP0003984_embryonic_growth_retardation1.40602006
51MP0001672_abnormal_embryogenesis/_devel1.40558657
52MP0005380_embryogenesis_phenotype1.40558657
53MP0002233_abnormal_nose_morphology1.38698243
54MP0000350_abnormal_cell_proliferation1.38262696
55MP0003935_abnormal_craniofacial_develop1.37803706
56MP0004145_abnormal_muscle_electrophysio1.37468853
57MP0001986_abnormal_taste_sensitivity1.37150391
58MP0002084_abnormal_developmental_patter1.35856631
59MP0009278_abnormal_bone_marrow1.33310239
60MP0002938_white_spotting1.31791042
61MP0001835_abnormal_antigen_presentation1.31660229
62MP0002234_abnormal_pharynx_morphology1.30290558
63MP0004264_abnormal_extraembryonic_tissu1.29702618
64MP0002086_abnormal_extraembryonic_tissu1.29488435
65MP0001293_anophthalmia1.29220214
66MP0002735_abnormal_chemical_nociception1.26351604
67MP0003385_abnormal_body_wall1.25633300
68MP0005253_abnormal_eye_physiology1.24789563
69MP0001697_abnormal_embryo_size1.23497557
70MP0005187_abnormal_penis_morphology1.23100385
71MP0002085_abnormal_embryonic_tissue1.22353921
72MP0002751_abnormal_autonomic_nervous1.22170616
73MP0009053_abnormal_anal_canal1.21765936
74MP0000689_abnormal_spleen_morphology1.21662189
75MP0009703_decreased_birth_body1.21544034
76MP0001730_embryonic_growth_arrest1.21305115
77MP0001529_abnormal_vocalization1.20864666
78MP0003937_abnormal_limbs/digits/tail_de1.20555327
79MP0001790_abnormal_immune_system1.19680586
80MP0005387_immune_system_phenotype1.19680586
81MP0004142_abnormal_muscle_tone1.19193461
82MP0006292_abnormal_olfactory_placode1.17758076
83MP0002722_abnormal_immune_system1.17230080
84MP0010307_abnormal_tumor_latency1.16714099
85MP0002452_abnormal_antigen_presenting1.15559303
86MP0000537_abnormal_urethra_morphology1.13669740
87MP0000428_abnormal_craniofacial_morphol1.13340167
88MP0000716_abnormal_immune_system1.12221990
89MP0000733_abnormal_muscle_development1.11083953
90MP0000566_synostosis1.10033379
91MP0001486_abnormal_startle_reflex1.09741716
92MP0003300_gastrointestinal_ulcer1.09683226
93MP0003938_abnormal_ear_development1.09360418
94MP0000685_abnormal_immune_system1.09262879
95MP0002095_abnormal_skin_pigmentation1.09175792
96MP0003861_abnormal_nervous_system1.09171113
97MP0002184_abnormal_innervation1.08528110
98MP0002557_abnormal_social/conspecific_i1.07952026
99MP0002925_abnormal_cardiovascular_devel1.07231270
100MP0002420_abnormal_adaptive_immunity1.06830921
101MP0003115_abnormal_respiratory_system1.05819437
102MP0003195_calcinosis1.05067111
103MP0002752_abnormal_somatic_nervous1.04699762
104MP0005391_vision/eye_phenotype1.03308995
105MP0001819_abnormal_immune_cell1.03307509
106MP0003942_abnormal_urinary_system1.02335607
107MP0001879_abnormal_lymphatic_vessel1.02209043
108MP0002734_abnormal_mechanical_nocicepti1.01968963
109MP0000955_abnormal_spinal_cord1.01694586
110MP0003136_yellow_coat_color1.00760533
111MP0005377_hearing/vestibular/ear_phenot1.00561738
112MP0003878_abnormal_ear_physiology1.00561738
113MP0005386_behavior/neurological_phenoty1.00137952
114MP0004924_abnormal_behavior1.00137952
115MP0005195_abnormal_posterior_eye0.99988625
116MP0002272_abnormal_nervous_system0.99885817
117MP0009672_abnormal_birth_weight0.98822598
118MP0001485_abnormal_pinna_reflex0.98141392
119MP0001286_abnormal_eye_development0.97909589
120MP0002429_abnormal_blood_cell0.97450186
121MP0009046_muscle_twitch0.96737829
122MP0000516_abnormal_urinary_system0.96208141
123MP0005367_renal/urinary_system_phenotyp0.96208141
124MP0002723_abnormal_immune_serum0.95863804
125MP0000432_abnormal_head_morphology0.94979254
126MP0005645_abnormal_hypothalamus_physiol0.93995447
127MP0009745_abnormal_behavioral_response0.93706138
128MP0002160_abnormal_reproductive_system0.93161375
129MP0002080_prenatal_lethality0.93001624
130MP0002822_catalepsy0.91891689
131MP0002067_abnormal_sensory_capabilities0.91716577
132MP0001545_abnormal_hematopoietic_system0.91422620
133MP0005397_hematopoietic_system_phenotyp0.91422620
134MP0002092_abnormal_eye_morphology0.90496538
135MP0002653_abnormal_ependyma_morphology0.90167319
136MP0002932_abnormal_joint_morphology0.89333851
137MP0002882_abnormal_neuron_morphology0.89196816
138MP0002019_abnormal_tumor_incidence0.88914646
139MP0001915_intracranial_hemorrhage0.87948388
140MP0003698_abnormal_male_reproductive0.87834872
141MP0000015_abnormal_ear_pigmentation0.87669623
142MP0003119_abnormal_digestive_system0.87661251
143MP0000427_abnormal_hair_cycle0.87557191
144MP0001299_abnormal_eye_distance/0.87518315
145MP0002152_abnormal_brain_morphology0.86791649
146MP0002210_abnormal_sex_determination0.86722836
147MP0001324_abnormal_eye_pigmentation0.86505838
148MP0004742_abnormal_vestibular_system0.85514278
149MP0003635_abnormal_synaptic_transmissio0.84949078
150MP0001968_abnormal_touch/_nociception0.83798321
151MP0000372_irregular_coat_pigmentation0.83783296
152MP0002572_abnormal_emotion/affect_behav0.83182329
153MP0000049_abnormal_middle_ear0.82550885
154MP0002877_abnormal_melanocyte_morpholog0.82530384
155MP0001929_abnormal_gametogenesis0.82235949
156MP0000383_abnormal_hair_follicle0.81749643
157MP0000490_abnormal_crypts_of0.81255874
158MP0002063_abnormal_learning/memory/cond0.80447359
159MP0000647_abnormal_sebaceous_gland0.80382410
160MP0008775_abnormal_heart_ventricle0.80250903
161MP0002928_abnormal_bile_duct0.79883548
162MP0005075_abnormal_melanosome_morpholog0.78973792
163MP0002405_respiratory_system_inflammati0.77627438
164MP0003755_abnormal_palate_morphology0.77359947
165MP0000653_abnormal_sex_gland0.77352188
166MP0000266_abnormal_heart_morphology0.77132152
167MP0005248_abnormal_Harderian_gland0.76873487
168MP0000313_abnormal_cell_death0.76816726
169MP0002109_abnormal_limb_morphology0.76584780
170MP0010030_abnormal_orbit_morphology0.75701619
171MP0008961_abnormal_basal_metabolism0.75696682
172MP0002116_abnormal_craniofacial_bone0.75506681

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.70648482
2Abnormality of the fingertips (HP:0001211)4.29111850
3Short 4th metacarpal (HP:0010044)3.79515506
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.79515506
5Pancreatic cysts (HP:0001737)3.35942130
6Hyperventilation (HP:0002883)3.31250642
7Chronic hepatic failure (HP:0100626)3.28547942
8Broad-based gait (HP:0002136)3.23817556
9Pancreatic fibrosis (HP:0100732)3.17711280
10Molar tooth sign on MRI (HP:0002419)3.16214518
11Abnormality of midbrain morphology (HP:0002418)3.16214518
12Hip dysplasia (HP:0001385)3.11633346
13Nephronophthisis (HP:0000090)3.07819479
14True hermaphroditism (HP:0010459)3.04932148
15Long eyelashes (HP:0000527)3.02030002
16Abnormality of the renal medulla (HP:0100957)2.94612984
17Abnormality of the renal cortex (HP:0011035)2.91690391
18Oligodactyly (hands) (HP:0001180)2.85353835
19Carpal bone hypoplasia (HP:0001498)2.80710156
20Macroorchidism (HP:0000053)2.80132415
21Abnormality of the 4th metacarpal (HP:0010012)2.75880897
22Medial flaring of the eyebrow (HP:0010747)2.67215520
23Drooling (HP:0002307)2.64063506
24Increased nuchal translucency (HP:0010880)2.63632513
25Tubulointerstitial nephritis (HP:0001970)2.56661570
26Trigonocephaly (HP:0000243)2.52076662
27Protruding tongue (HP:0010808)2.51989976
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.51642820
29Syringomyelia (HP:0003396)2.51273188
30Spinal cord lesions (HP:0100561)2.51273188
31Renal cortical cysts (HP:0000803)2.49867062
32Gait imbalance (HP:0002141)2.45860644
33Agammaglobulinemia (HP:0004432)2.44664158
34Medulloblastoma (HP:0002885)2.44027532
35Anencephaly (HP:0002323)2.43956939
36Small hand (HP:0200055)2.43532295
37Excessive salivation (HP:0003781)2.40960191
38Genital tract atresia (HP:0001827)2.39495726
39Colon cancer (HP:0003003)2.39002589
40Genetic anticipation (HP:0003743)2.38283084
41Congenital primary aphakia (HP:0007707)2.37972021
42Vaginal atresia (HP:0000148)2.36923342
43Hip contracture (HP:0003273)2.32795928
44Renal duplication (HP:0000075)2.31960840
45Abnormality of the labia minora (HP:0012880)2.30372780
46Ectopic kidney (HP:0000086)2.29821516
47Obsessive-compulsive behavior (HP:0000722)2.28512640
48Absent frontal sinuses (HP:0002688)2.27375938
49Truncal obesity (HP:0001956)2.27326468
50Hyperacusis (HP:0010780)2.26492546
51Cystic liver disease (HP:0006706)2.26479043
52Optic nerve hypoplasia (HP:0000609)2.25825241
53Narrow palate (HP:0000189)2.25397507
54Nephrogenic diabetes insipidus (HP:0009806)2.23318656
55Deep philtrum (HP:0002002)2.22511484
56T lymphocytopenia (HP:0005403)2.22341757
57Supernumerary ribs (HP:0005815)2.22033123
58Chromsome breakage (HP:0040012)2.19920410
59Midline defect of the nose (HP:0004122)2.19532340
60Poor coordination (HP:0002370)2.19233700
61Hepatoblastoma (HP:0002884)2.18313487
62Abnormality of the intervertebral disk (HP:0005108)2.18210364
63Postaxial foot polydactyly (HP:0001830)2.17452405
64Recurrent bronchitis (HP:0002837)2.13107788
65Preaxial hand polydactyly (HP:0001177)2.10153736
66Septo-optic dysplasia (HP:0100842)2.08814264
67Abnormality of the nasal septum (HP:0000419)2.08788311
68Aqueductal stenosis (HP:0002410)2.08690944
69Progressive cerebellar ataxia (HP:0002073)2.08553788
70Oligodactyly (HP:0012165)2.07999188
71Cutis marmorata (HP:0000965)2.06595698
72Lissencephaly (HP:0001339)2.06182486
73Anophthalmia (HP:0000528)2.05921540
74Nephroblastoma (Wilms tumor) (HP:0002667)2.04955243
75Short tibia (HP:0005736)2.04859595
76Hypoplastic iliac wings (HP:0002866)2.03379005
77Disproportionate short-trunk short stature (HP:0003521)2.02995418
78Abnormality of the parietal bone (HP:0002696)2.02937684
79Supernumerary bones of the axial skeleton (HP:0009144)2.01984469
80Tented upper lip vermilion (HP:0010804)2.01908838
81Abnormal number of incisors (HP:0011064)2.01747317
82Thyroiditis (HP:0100646)2.01563149
83Broad palm (HP:0001169)2.01179072
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00796129
85Fetal akinesia sequence (HP:0001989)2.00270101
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99116688
87Increased density of long bones (HP:0006392)1.98675771
88Abnormality of the aortic arch (HP:0012303)1.98427437
89Abnormality of chromosome segregation (HP:0002916)1.97705965
90Postaxial hand polydactyly (HP:0001162)1.96992106
91Abnormality of T cell number (HP:0011839)1.96743538
92Acute myeloid leukemia (HP:0004808)1.96108377
93Broad thumb (HP:0011304)1.95810807
94Prominent nose (HP:0000448)1.94375489
95Thick eyebrow (HP:0000574)1.93562180
96Limited hip movement (HP:0008800)1.93431638
97Low anterior hairline (HP:0000294)1.93261389
98Abnormality of the septum pellucidum (HP:0007375)1.92993634
99Barrel-shaped chest (HP:0001552)1.92751577
100Vertebral arch anomaly (HP:0008438)1.92316605
101Gaze-evoked nystagmus (HP:0000640)1.92213682
102Embryonal renal neoplasm (HP:0011794)1.92176222
103Exotropia (HP:0000577)1.92138921
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.92043126
105Recurrent viral infections (HP:0004429)1.91724175
106Proximal placement of thumb (HP:0009623)1.90806151
107Deviation of the thumb (HP:0009603)1.90628498
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.90187011
109Cupped ear (HP:0000378)1.90072515
110Hypoplastic labia majora (HP:0000059)1.89568412
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89511775
112Dislocated radial head (HP:0003083)1.88768611
113Acute lymphatic leukemia (HP:0006721)1.88674232
114Long clavicles (HP:0000890)1.87962730
115IgM deficiency (HP:0002850)1.87121356
116Absent septum pellucidum (HP:0001331)1.83973706
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83857176
118Highly arched eyebrow (HP:0002553)1.83120823
119Anal stenosis (HP:0002025)1.82992303
120Absent speech (HP:0001344)1.82884853
121Congenital hepatic fibrosis (HP:0002612)1.82490898
122Abnormal biliary tract physiology (HP:0012439)1.82141000
123Bile duct proliferation (HP:0001408)1.82141000
124Facial hemangioma (HP:0000329)1.81800880
125Dandy-Walker malformation (HP:0001305)1.81657878
126Intestinal atresia (HP:0011100)1.81489942
127Abnormality of B cell number (HP:0010975)1.80669070
128B lymphocytopenia (HP:0010976)1.80669070
129Hypoplasia of the maxilla (HP:0000327)1.80507888
130Panhypogammaglobulinemia (HP:0003139)1.79536247
131Urethral obstruction (HP:0000796)1.79472352
132High pitched voice (HP:0001620)1.79209950
133Tubulointerstitial abnormality (HP:0001969)1.78577253
134Neoplasm of the oral cavity (HP:0100649)1.78254189
135Abnormality of the radial head (HP:0003995)1.78018014
136Narrow forehead (HP:0000341)1.77890864
137Abnormality of the middle phalanges of the toes (HP:0010183)1.77858660
138Asymmetry of the thorax (HP:0001555)1.77426460
139Renal hypoplasia (HP:0000089)1.77366580
140Optic nerve coloboma (HP:0000588)1.77049041
141Labial hypoplasia (HP:0000066)1.76742457
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.76663441
143Abnormal hair whorl (HP:0010721)1.76247710
144Heterotopia (HP:0002282)1.75823329
145Short foot (HP:0001773)1.75771732
146Progressive inability to walk (HP:0002505)1.75552081
147Diastasis recti (HP:0001540)1.75129867
148Papillary thyroid carcinoma (HP:0002895)1.74740741
149Sclerocornea (HP:0000647)1.74476640
150Skin tags (HP:0010609)1.74466346
151Renovascular hypertension (HP:0100817)1.74413089
152High anterior hairline (HP:0009890)1.74281039
153Sloping forehead (HP:0000340)1.73850210
154Patellar aplasia (HP:0006443)1.73421215
155Broad phalanges of the hand (HP:0009768)1.72489475
156Neoplasm of the adrenal cortex (HP:0100641)1.72462842
157Limited elbow extension (HP:0001377)1.72221623
158Spinal muscular atrophy (HP:0007269)1.72219779
159Bifid tongue (HP:0010297)1.71377082
160Fair hair (HP:0002286)1.71341850
161Abnormality of the incisor (HP:0000676)1.70405982
162Pachygyria (HP:0001302)1.69710162
163Cutaneous finger syndactyly (HP:0010554)1.69312728
164Congenital stationary night blindness (HP:0007642)1.69107679
165Tubular atrophy (HP:0000092)1.68517169
166Depressed nasal tip (HP:0000437)1.68201558
167Bicuspid aortic valve (HP:0001647)1.67834446
168Skull defect (HP:0001362)1.67717027
169Synophrys (HP:0000664)1.67533372
170Abnormality of chromosome stability (HP:0003220)1.67296818
171Tapered finger (HP:0001182)1.65646112
172Lip pit (HP:0100267)1.65357620
173Abnormality of the metopic suture (HP:0005556)1.65323082
174Lymphopenia (HP:0001888)1.64279350
175Broad finger (HP:0001500)1.64147590
176Abnormality of the labia majora (HP:0012881)1.64123056
177Abnormal lung lobation (HP:0002101)1.63190172
178Neoplasm of striated muscle (HP:0009728)1.62609195
179Intestinal malrotation (HP:0002566)1.62430023
180Hypochromic microcytic anemia (HP:0004840)1.61569641
181Rhabdomyosarcoma (HP:0002859)1.60574053
182Ependymoma (HP:0002888)1.60306025
183Abnormal delayed hypersensitivity skin test (HP:0002963)1.59259942
184Supernumerary spleens (HP:0009799)1.58716112
185Myelodysplasia (HP:0002863)1.58687448
186Smooth philtrum (HP:0000319)1.58280042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.88018735
2BRD43.54173712
3CASK3.41514651
4MAP3K103.28757461
5CDC72.94327915
6WNK32.76598444
7MARK12.68078573
8MAP3K42.67604884
9TNIK2.67159479
10MAP4K12.42694556
11MKNK22.19060663
12PASK2.04423812
13MAPK132.01526810
14MKNK12.01142607
15WNK41.98390275
16CAMK1D1.88881796
17TGFBR11.88849607
18CDK91.87278741
19EEF2K1.82517563
20STK391.77653545
21CAMK1G1.73946581
22NEK21.61872511
23ATR1.60328110
24CDK61.53450493
25SRPK11.52299687
26CDK41.52119197
27FGFR31.50047752
28EPHA41.45724832
29MAP2K71.42826231
30BCR1.41956901
31RPS6KA41.39199206
32ITK1.37509919
33MAP3K71.32020899
34BTK1.31935857
35TEC1.28958959
36PNCK1.28319194
37MAP4K21.26409770
38TXK1.25869730
39NUAK11.25290626
40MELK1.23227146
41STK101.23070247
42CDK71.22403196
43DYRK21.22188374
44ZAK1.21532045
45OBSCN1.19862496
46LATS11.19745550
47ATM1.19336538
48CSF1R1.16049281
49DYRK31.15808937
50PIM11.14173846
51OXSR11.14159238
52STK38L1.13170236
53PLK21.12908818
54TGFBR21.11958458
55TAOK31.11122997
56YES11.11121539
57CHUK1.10898093
58CDK81.09932713
59CHEK11.09898939
60PINK11.08972068
61AKT31.08621544
62FGFR21.07934484
63CHEK21.06214572
64TRIM281.05884994
65RPS6KB21.02149126
66SGK31.00663837
67STK31.00244180
68SGK20.99559460
69PAK30.98104155
70HIPK20.98092931
71SIK20.98026515
72NTRK20.97908090
73STK40.97197204
74CDK30.96377156
75PLK30.93263968
76FRK0.91817310
77SGK2230.90555012
78SGK4940.90555012
79ERBB30.89370647
80FLT30.89289271
81ACVR1B0.88175832
82ADRBK20.87326271
83STK110.87311138
84PTK60.87260563
85CLK10.86875894
86MTOR0.85253496
87CDK20.84570475
88NTRK30.83812459
89TSSK60.82964551
90CSNK1G10.82427026
91TLK10.81371473
92GRK10.80139267
93AURKB0.79234262
94KIT0.78727782
95VRK10.76541616
96BRSK20.75717961
97NLK0.75475481
98WEE10.74318570
99PRKAA10.73492046
100FGFR10.72287246
101CAMKK20.72030227
102PKN20.71778056
103GRK60.70251453
104CSNK1G20.68971053
105JAK30.68770971
106DYRK1A0.67892519
107CDK10.67669816
108WNK10.66425015
109RPS6KA50.66412694
110MAPK140.65925713
111MAP2K40.64853371
112LCK0.63974501
113RPS6KB10.63833123
114CSNK1A1L0.63103397
115SYK0.61508813
116DYRK1B0.61327674
117EPHA30.60815655
118FGFR40.60277268
119PIK3CA0.60193781
120PLK40.59492967
121SCYL20.59081443
122MAP3K140.58383796
123SGK10.58348868
124NEK90.57272158
125PRKDC0.57205315
126PRKCE0.56824554
127PRKAA20.55954908
128MARK30.55180911
129CDC42BPA0.54555869
130TYK20.53586740
131CSNK1D0.52281993
132JAK10.51805192
133AKT10.51498126
134BMPR1B0.50432134
135MAPK10.50160151
136ERBB20.49924751
137TYRO30.49810740
138CSNK1G30.49510992
139PTK2B0.49478504
140PLK10.49175774
141TTK0.49116862
142PRKCG0.48286641
143HCK0.47752272
144CSK0.47104897
145CSNK1E0.47104255
146INSRR0.46861964
147LYN0.46450113
148GSK3B0.45529096
149CAMK10.45151359
150STK380.44192670
151CAMK40.43966264

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.58064431
2Nicotine addiction_Homo sapiens_hsa050332.52823811
3Non-homologous end-joining_Homo sapiens_hsa034502.38618320
4Mismatch repair_Homo sapiens_hsa034302.37977278
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31866134
6Phototransduction_Homo sapiens_hsa047442.24703741
7Cell cycle_Homo sapiens_hsa041102.20417558
8Spliceosome_Homo sapiens_hsa030402.16865890
9DNA replication_Homo sapiens_hsa030302.12183153
10Butanoate metabolism_Homo sapiens_hsa006502.08904955
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08493105
12B cell receptor signaling pathway_Homo sapiens_hsa046622.05742991
13Circadian rhythm_Homo sapiens_hsa047101.98782448
14mRNA surveillance pathway_Homo sapiens_hsa030151.98363877
15Lysine degradation_Homo sapiens_hsa003101.90626573
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.89033612
17Regulation of autophagy_Homo sapiens_hsa041401.84394569
18Base excision repair_Homo sapiens_hsa034101.84331027
19Fanconi anemia pathway_Homo sapiens_hsa034601.76590375
20Taste transduction_Homo sapiens_hsa047421.76050933
21Propanoate metabolism_Homo sapiens_hsa006401.72571632
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70983264
23Herpes simplex infection_Homo sapiens_hsa051681.63490432
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.62792567
25RNA degradation_Homo sapiens_hsa030181.58663206
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56390051
27RNA transport_Homo sapiens_hsa030131.55593325
28Antigen processing and presentation_Homo sapiens_hsa046121.53043451
29T cell receptor signaling pathway_Homo sapiens_hsa046601.50410909
30MicroRNAs in cancer_Homo sapiens_hsa052061.50060860
31Homologous recombination_Homo sapiens_hsa034401.49488712
32Chronic myeloid leukemia_Homo sapiens_hsa052201.49364327
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46528210
34Protein export_Homo sapiens_hsa030601.43698919
35Olfactory transduction_Homo sapiens_hsa047401.40361883
36HTLV-I infection_Homo sapiens_hsa051661.39569792
37Notch signaling pathway_Homo sapiens_hsa043301.35150647
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34717964
39Nucleotide excision repair_Homo sapiens_hsa034201.33987036
40Measles_Homo sapiens_hsa051621.31475879
41Linoleic acid metabolism_Homo sapiens_hsa005911.29301454
42Colorectal cancer_Homo sapiens_hsa052101.28983934
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28943394
44Hepatitis B_Homo sapiens_hsa051611.25728418
45ABC transporters_Homo sapiens_hsa020101.24997024
46Small cell lung cancer_Homo sapiens_hsa052221.23706146
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23513413
48Prostate cancer_Homo sapiens_hsa052151.22567622
49Viral carcinogenesis_Homo sapiens_hsa052031.22407487
50Basal cell carcinoma_Homo sapiens_hsa052171.22201727
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21356910
52Steroid biosynthesis_Homo sapiens_hsa001001.18818439
53Nitrogen metabolism_Homo sapiens_hsa009101.16279163
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15705116
55Non-small cell lung cancer_Homo sapiens_hsa052231.15090578
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15004617
57Glutamatergic synapse_Homo sapiens_hsa047241.13670410
58Axon guidance_Homo sapiens_hsa043601.13450031
59Systemic lupus erythematosus_Homo sapiens_hsa053221.13354247
60Osteoclast differentiation_Homo sapiens_hsa043801.11315723
61Hematopoietic cell lineage_Homo sapiens_hsa046401.10783811
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09981576
63Adherens junction_Homo sapiens_hsa045201.09631212
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08885641
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07004232
66Morphine addiction_Homo sapiens_hsa050321.06393896
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06124028
68Pancreatic cancer_Homo sapiens_hsa052121.05723351
69GABAergic synapse_Homo sapiens_hsa047271.05633238
70TGF-beta signaling pathway_Homo sapiens_hsa043501.05547048
71Selenocompound metabolism_Homo sapiens_hsa004501.05437727
72Epstein-Barr virus infection_Homo sapiens_hsa051691.03594024
73Caffeine metabolism_Homo sapiens_hsa002321.03570121
74Wnt signaling pathway_Homo sapiens_hsa043101.02475552
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02292174
76Viral myocarditis_Homo sapiens_hsa054161.00651914
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99686574
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.99019498
79RNA polymerase_Homo sapiens_hsa030200.98598505
80Circadian entrainment_Homo sapiens_hsa047130.97413272
81mTOR signaling pathway_Homo sapiens_hsa041500.96020247
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95701546
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.95441453
84Acute myeloid leukemia_Homo sapiens_hsa052210.95258045
85FoxO signaling pathway_Homo sapiens_hsa040680.91932034
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.91724262
87Influenza A_Homo sapiens_hsa051640.91007858
88p53 signaling pathway_Homo sapiens_hsa041150.90808555
89Ether lipid metabolism_Homo sapiens_hsa005650.90438494
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90219393
91Tryptophan metabolism_Homo sapiens_hsa003800.88630464
92Hedgehog signaling pathway_Homo sapiens_hsa043400.87910932
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87592159
94Pathways in cancer_Homo sapiens_hsa052000.86635119
95Leishmaniasis_Homo sapiens_hsa051400.84512331
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83192179
97Proteoglycans in cancer_Homo sapiens_hsa052050.82267903
98Endometrial cancer_Homo sapiens_hsa052130.81982156
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81337812
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.80391525
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.80239587
102Dopaminergic synapse_Homo sapiens_hsa047280.78601600
103Hippo signaling pathway_Homo sapiens_hsa043900.77101548
104Basal transcription factors_Homo sapiens_hsa030220.76831802
105Platelet activation_Homo sapiens_hsa046110.76647588
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75452451
107Serotonergic synapse_Homo sapiens_hsa047260.74936334
108Calcium signaling pathway_Homo sapiens_hsa040200.74056761
109Toxoplasmosis_Homo sapiens_hsa051450.71069183
110Insulin secretion_Homo sapiens_hsa049110.70726013
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69888645
112One carbon pool by folate_Homo sapiens_hsa006700.69730644
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69433383
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.69415166
115Thyroid cancer_Homo sapiens_hsa052160.69218446
116Chemokine signaling pathway_Homo sapiens_hsa040620.68622618
117Alcoholism_Homo sapiens_hsa050340.68248379
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68157757
119Cholinergic synapse_Homo sapiens_hsa047250.67934647
120Prolactin signaling pathway_Homo sapiens_hsa049170.64746818
121Type II diabetes mellitus_Homo sapiens_hsa049300.64010148
122Cardiac muscle contraction_Homo sapiens_hsa042600.63839070
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63719901
124Glycerolipid metabolism_Homo sapiens_hsa005610.63161009
125Oxytocin signaling pathway_Homo sapiens_hsa049210.63116915
126Peroxisome_Homo sapiens_hsa041460.63026252
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62660599
128MAPK signaling pathway_Homo sapiens_hsa040100.62120179
129TNF signaling pathway_Homo sapiens_hsa046680.62029559
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.58087930
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57681512
132Retinol metabolism_Homo sapiens_hsa008300.57588847
133Oocyte meiosis_Homo sapiens_hsa041140.57273864
134Insulin resistance_Homo sapiens_hsa049310.56877395
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55168667
136Focal adhesion_Homo sapiens_hsa045100.54391775
137Renal cell carcinoma_Homo sapiens_hsa052110.53529943
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53465143
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53302172
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52174334
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51646790
142cAMP signaling pathway_Homo sapiens_hsa040240.51585588
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51370690
144Glioma_Homo sapiens_hsa052140.50865695
145Glucagon signaling pathway_Homo sapiens_hsa049220.50524184
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50285329
147Cocaine addiction_Homo sapiens_hsa050300.49488886
148Apoptosis_Homo sapiens_hsa042100.48625092
149Dorso-ventral axis formation_Homo sapiens_hsa043200.47127860
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45192101
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45164829
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45064271
153Long-term depression_Homo sapiens_hsa047300.44589206
154Melanogenesis_Homo sapiens_hsa049160.44339520
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43352236
156Shigellosis_Homo sapiens_hsa051310.43329259
157Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43316630
158Inositol phosphate metabolism_Homo sapiens_hsa005620.42504300
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42347601
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42154882
161Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40655130

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