ZCCHC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. The encoded protein contains six CCHC-type zinc fingers, and is thus thought to function as a transcription factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.63739095
2axonemal dynein complex assembly (GO:0070286)9.62955820
3spermatid development (GO:0007286)9.18087280
4motile cilium assembly (GO:0044458)8.67942120
5regulation of cilium movement (GO:0003352)8.09002895
6cilium movement (GO:0003341)8.07795174
7single fertilization (GO:0007338)7.74983356
8male meiosis (GO:0007140)7.70355413
9sperm capacitation (GO:0048240)7.69494216
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39812943
11synaptonemal complex assembly (GO:0007130)7.29126454
12synaptonemal complex organization (GO:0070193)7.19740748
13piRNA metabolic process (GO:0034587)6.52124277
14spermatid nucleus differentiation (GO:0007289)6.38175362
15fertilization (GO:0009566)6.31024815
16spermatogenesis (GO:0007283)6.15981800
17microtubule depolymerization (GO:0007019)6.13899492
18male gamete generation (GO:0048232)6.13803088
19negative regulation of inclusion body assembly (GO:0090084)5.92131453
20organic cation transport (GO:0015695)5.74531748
21gamete generation (GO:0007276)5.67719697
22calcium ion-dependent exocytosis (GO:0017156)5.25976215
23microtubule severing (GO:0051013)5.25792303
24cell recognition (GO:0008037)5.25221298
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.25021002
26ventricular system development (GO:0021591)5.17770753
27regulation of inclusion body assembly (GO:0090083)5.11860069
28germ cell development (GO:0007281)5.07054493
29chromosome organization involved in meiosis (GO:0070192)4.98068798
30regulation of microtubule-based movement (GO:0060632)4.68721558
31monoubiquitinated protein deubiquitination (GO:0035520)4.57977058
32glycerol ether metabolic process (GO:0006662)4.56511638
33male meiosis I (GO:0007141)4.48672214
34meiotic nuclear division (GO:0007126)4.46368800
35multicellular organismal reproductive process (GO:0048609)4.45864892
36chromosome condensation (GO:0030261)4.23408590
37single strand break repair (GO:0000012)4.21971768
38ether metabolic process (GO:0018904)4.21651950
39DNA methylation involved in gamete generation (GO:0043046)4.19314783
40protein polyglutamylation (GO:0018095)4.06158424
41sexual reproduction (GO:0019953)4.04983030
42DNA packaging (GO:0006323)3.91807922
43seminiferous tubule development (GO:0072520)3.76728489
44protein K11-linked deubiquitination (GO:0035871)3.72247018
45meiosis I (GO:0007127)3.65817791
46multicellular organismal development (GO:0007275)3.56443678
47chaperone-mediated protein complex assembly (GO:0051131)3.53228218
48left/right pattern formation (GO:0060972)3.47467577
49genitalia morphogenesis (GO:0035112)3.39462256
50microtubule polymerization or depolymerization (GO:0031109)3.26377213
51regulation of spindle checkpoint (GO:0090231)3.22528601
52carnitine transport (GO:0015879)3.07095763
53amino-acid betaine transport (GO:0015838)3.07095763
54nucleus organization (GO:0006997)3.05275835
55positive regulation of macrophage activation (GO:0043032)2.98179397
56synapsis (GO:0007129)2.96065470
57carnitine transmembrane transport (GO:1902603)2.96008795
58meiotic cell cycle (GO:0051321)2.94564145
59glycolytic process (GO:0006096)2.89856637
60centriole assembly (GO:0098534)2.89516050
61meiotic cell cycle process (GO:1903046)2.88344369
62cilium organization (GO:0044782)2.85300515
63intraciliary transport (GO:0042073)2.80732658
64protein localization to cilium (GO:0061512)2.80262743
65sequestering of actin monomers (GO:0042989)2.79233377
66polyol catabolic process (GO:0046174)2.78562656
67cellular component assembly involved in morphogenesis (GO:0010927)2.77535597
68microtubule-based movement (GO:0007018)2.77330835
69cilium assembly (GO:0042384)2.72932270
70centriole replication (GO:0007099)2.68613087
71nucleoside diphosphate phosphorylation (GO:0006165)2.68134483
72protein refolding (GO:0042026)2.66868055
73interferon-gamma secretion (GO:0072643)2.65219385
74mitotic sister chromatid cohesion (GO:0007064)2.64215190
75GTP biosynthetic process (GO:0006183)2.59103183
76alditol metabolic process (GO:0019400)2.58967148
77cilium morphogenesis (GO:0060271)2.56357457
78regulation of centriole replication (GO:0046599)2.50477000
79gene silencing by RNA (GO:0031047)2.50421110
80negative regulation of organelle assembly (GO:1902116)2.47595404
81peptidyl-glutamic acid modification (GO:0018200)2.45987590
82calcium ion import (GO:0070509)2.44854898
83lactate metabolic process (GO:0006089)2.44825099
84chromatin silencing (GO:0006342)2.41938316
85histone exchange (GO:0043486)2.40148188
86axoneme assembly (GO:0035082)2.38327566
87nuclear pore complex assembly (GO:0051292)2.37022705
88cell wall macromolecule metabolic process (GO:0044036)15.2075428
89cell wall macromolecule catabolic process (GO:0016998)15.2075428
90fusion of sperm to egg plasma membrane (GO:0007342)14.0575629
91sperm motility (GO:0030317)13.1267873
92acrosome assembly (GO:0001675)13.0577793
93multicellular organism reproduction (GO:0032504)12.2934690
94sperm-egg recognition (GO:0035036)12.0736346
95acrosome reaction (GO:0007340)10.9957652
96cell-cell recognition (GO:0009988)10.8248694
97plasma membrane fusion (GO:0045026)10.7090246
98binding of sperm to zona pellucida (GO:0007339)10.5181075
99reproduction (GO:0000003)10.4615492
100cilium or flagellum-dependent cell motility (GO:0001539)10.0522887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.93120498
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.24325210
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.59704911
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12848146
5EZH2_22144423_ChIP-Seq_EOC_Human2.88303313
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68408479
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.51445730
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49747667
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35670764
10KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.23158685
11VDR_22108803_ChIP-Seq_LS180_Human2.21389298
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.20644811
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.17764433
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15253163
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09079389
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08716379
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94639710
18RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.94123272
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.92135189
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.89264071
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86531714
22ZNF274_21170338_ChIP-Seq_K562_Hela1.86144308
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73565261
24STAT1_17558387_ChIP-Seq_HELA_Human1.69380691
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.69363993
26KDM2B_26808549_Chip-Seq_REH_Human1.65524319
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63328759
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62504902
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60276913
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.59996437
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59172704
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.58487346
33GATA3_21867929_ChIP-Seq_CD8_Mouse1.56005029
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55909166
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55111605
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51929812
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.46846420
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45737805
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44505507
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.42673141
41FLI1_21867929_ChIP-Seq_TH2_Mouse1.42506969
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.41763025
43CBP_20019798_ChIP-Seq_JUKART_Human1.39594755
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39594755
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39155134
46RNF2_27304074_Chip-Seq_NSC_Mouse1.36401220
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.35192598
48LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33581911
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.32186138
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.31533040
51RUNX1_26923725_Chip-Seq_HPCs_Mouse1.31265807
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29686507
53GF1_26923725_Chip-Seq_HPCs_Mouse1.25925002
54P53_22387025_ChIP-Seq_ESCs_Mouse1.25500347
55KLF4_18555785_Chip-Seq_ESCs_Mouse1.23630566
56P300_18555785_Chip-Seq_ESCs_Mouse1.23133244
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.21186949
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21073659
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20939965
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20794251
61CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19673680
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19032628
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.18139159
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18137902
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17748724
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17733215
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17583072
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16827472
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16827472
70P53_21459846_ChIP-Seq_SAOS-2_Human1.14687789
71REST_21632747_ChIP-Seq_MESCs_Mouse1.14264139
72SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13032858
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.12838904
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12716550
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.12684359
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12044512
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.10520686
78ESET_19884257_ChIP-Seq_ESCs_Mouse1.06704137
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05727412
80CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05374674
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02709405
82RARA_24833708_ChIP-Seq_LIVER_Mouse1.01673432
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.00679320
84LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00301802
85NMYC_18555785_Chip-Seq_ESCs_Mouse0.99675411
86GF1B_26923725_Chip-Seq_HPCs_Mouse0.99603898
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99238758
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99198679
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98731835
90STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97554298
91TAF15_26573619_Chip-Seq_HEK293_Human0.97179113
92PU1_27457419_Chip-Seq_LIVER_Mouse0.96279336
93SOX9_26525672_Chip-Seq_HEART_Mouse0.95220854
94GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94493116
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94379531
96ZFX_18555785_Chip-Seq_ESCs_Mouse0.94187196
97ERG_20517297_ChIP-Seq_VCAP_Human0.93634793
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93294823
99FLI1_21867929_ChIP-Seq_CD8_Mouse0.93038032
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92781671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10874249
2MP0001929_abnormal_gametogenesis5.62763661
3MP0008877_abnormal_DNA_methylation4.48972486
4MP0002653_abnormal_ependyma_morphology3.62111961
5MP0002210_abnormal_sex_determination3.55149955
6MP0002161_abnormal_fertility/fecundity3.34667825
7MP0001145_abnormal_male_reproductive3.07150052
8MP0000653_abnormal_sex_gland2.70897895
9MP0005670_abnormal_white_adipose2.22277577
10MP0005623_abnormal_meninges_morphology2.07654659
11MP0005410_abnormal_fertilization15.8104154
12MP0003646_muscle_fatigue1.69046349
13MP0008058_abnormal_DNA_repair1.57434169
14MP0009046_muscle_twitch1.56035761
15MP0004233_abnormal_muscle_weight1.55964050
16MP0002282_abnormal_trachea_morphology1.42669109
17MP0002160_abnormal_reproductive_system1.22226563
18MP0001765_abnormal_ion_homeostasis1.11560629
19MP0008057_abnormal_DNA_replication1.10260328
20MP0005647_abnormal_sex_gland1.08264184
21MP0001984_abnormal_olfaction0.97343214
22MP0002102_abnormal_ear_morphology0.95515564
23MP0010094_abnormal_chromosome_stability0.91823187
24MP0008995_early_reproductive_senescence0.75275468
25MP0005389_reproductive_system_phenotype0.69211531
26MP0003699_abnormal_female_reproductive0.68958535
27MP0002234_abnormal_pharynx_morphology0.61837973
28MP0004036_abnormal_muscle_relaxation0.57438739
29MP0005636_abnormal_mineral_homeostasis0.55629349
30MP0001119_abnormal_female_reproductive0.54539493
31MP0001293_anophthalmia0.53728353
32MP0003111_abnormal_nucleus_morphology0.53611189
33MP0010307_abnormal_tumor_latency0.52597235
34MP0003115_abnormal_respiratory_system0.51279369
35MP0002928_abnormal_bile_duct0.49944914
36MP0001324_abnormal_eye_pigmentation0.48501519
37MP0001730_embryonic_growth_arrest0.43492375
38MP0005397_hematopoietic_system_phenotyp0.43338740
39MP0001545_abnormal_hematopoietic_system0.43338740
40MP0003786_premature_aging0.43207126
41MP0008007_abnormal_cellular_replicative0.43099089
42MP0003950_abnormal_plasma_membrane0.42572912
43MP0000358_abnormal_cell_content/0.42143198
44MP0001764_abnormal_homeostasis0.41879049
45MP0003011_delayed_dark_adaptation0.40874650
46MP0005666_abnormal_adipose_tissue0.40006246
47MP0002269_muscular_atrophy0.39990294
48MP0004133_heterotaxia0.39591386
49MP0005551_abnormal_eye_electrophysiolog0.38849418
50MP0002132_abnormal_respiratory_system0.38745268
51MP0004084_abnormal_cardiac_muscle0.36490174
52MP0004019_abnormal_vitamin_homeostasis0.36404980
53MP0002084_abnormal_developmental_patter0.36061149
54MP0003633_abnormal_nervous_system0.35615967
55MP0005377_hearing/vestibular/ear_phenot0.35280776
56MP0003878_abnormal_ear_physiology0.35280776
57MP0005253_abnormal_eye_physiology0.34140053
58MP0009278_abnormal_bone_marrow0.33582573
59MP0009115_abnormal_fat_cell0.33057331
60MP0003861_abnormal_nervous_system0.31656190
61MP0002971_abnormal_brown_adipose0.30995006
62MP0006036_abnormal_mitochondrial_physio0.29982239
63MP0000462_abnormal_digestive_system0.29271132
64MP0001697_abnormal_embryo_size0.28063209
65MP0005391_vision/eye_phenotype0.27255802
66MP0000313_abnormal_cell_death0.27135284
67MP0003631_nervous_system_phenotype0.26715570
68MP0001672_abnormal_embryogenesis/_devel0.26003255
69MP0005380_embryogenesis_phenotype0.26003255
70MP0002085_abnormal_embryonic_tissue0.25243157
71MP0003077_abnormal_cell_cycle0.24150782
72MP0000432_abnormal_head_morphology0.24064257
73MP0004145_abnormal_muscle_electrophysio0.23985129
74MP0002152_abnormal_brain_morphology0.23661781
75MP0002736_abnormal_nociception_after0.23029277
76MP0002169_no_abnormal_phenotype0.22910805
77MP0002873_normal_phenotype0.22627729
78MP0003329_amyloid_beta_deposits0.22002993
79MP0003984_embryonic_growth_retardation0.21777392
80MP0000534_abnormal_ureter_morphology0.20958157
81MP0002139_abnormal_hepatobiliary_system0.20871471
82MP0000569_abnormal_digit_pigmentation0.20443572
83MP0009250_abnormal_appendicular_skeleto0.20421646
84MP0004811_abnormal_neuron_physiology0.19568539
85MP0005195_abnormal_posterior_eye0.19057513
86MP0002088_abnormal_embryonic_growth/wei0.18482274
87MP0002405_respiratory_system_inflammati0.17946335
88MP0002080_prenatal_lethality0.16613166
89MP0008875_abnormal_xenobiotic_pharmacok0.16541280
90MP0002009_preneoplasia0.16513502
91MP0005451_abnormal_body_composition0.15796805
92MP0000001_mammalian_phenotype0.15103829
93MP0006072_abnormal_retinal_apoptosis0.14527063
94MP0003943_abnormal_hepatobiliary_system0.14516911
95MP0005365_abnormal_bile_salt0.14242968
96MP0002837_dystrophic_cardiac_calcinosis0.13715794
97MP0009697_abnormal_copulation0.13489261
98MP0003787_abnormal_imprinting0.13368722
99MP0001919_abnormal_reproductive_system0.12822675
100MP0004957_abnormal_blastocyst_morpholog0.12633221

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.58621237
2Abnormal respiratory epithelium morphology (HP:0012253)8.81149567
3Abnormal respiratory motile cilium morphology (HP:0005938)8.81149567
4Abnormal ciliary motility (HP:0012262)7.95124933
5Rhinitis (HP:0012384)7.59866718
6Chronic bronchitis (HP:0004469)7.40166281
7Nasal polyposis (HP:0100582)6.30481626
8Infertility (HP:0000789)6.25856030
9Abnormality of the nasal mucosa (HP:0000433)5.16610896
10Male infertility (HP:0003251)5.02231730
11Bronchitis (HP:0012387)4.63185465
12Bronchiectasis (HP:0002110)4.48247104
13Nephronophthisis (HP:0000090)4.04012702
14Abnormal spermatogenesis (HP:0008669)3.87227521
15Recurrent sinusitis (HP:0011108)3.61730757
16Recurrent otitis media (HP:0000403)3.34565385
17Medial flaring of the eyebrow (HP:0010747)3.03326425
18Abnormality of the renal medulla (HP:0100957)3.01766453
19Abnormality of midbrain morphology (HP:0002418)2.92003554
20Molar tooth sign on MRI (HP:0002419)2.92003554
21Recurrent bronchitis (HP:0002837)2.78531589
22Azoospermia (HP:0000027)2.72026742
23Tubular atrophy (HP:0000092)2.55802860
24Tubulointerstitial nephritis (HP:0001970)2.55262306
25Tongue fasciculations (HP:0001308)2.54512896
26Muscle fibrillation (HP:0010546)2.31739610
27Tubulointerstitial abnormality (HP:0001969)2.30968628
28Impulsivity (HP:0100710)2.26049756
29Pancreatic fibrosis (HP:0100732)2.22654423
30Microglossia (HP:0000171)2.08827790
31Postaxial foot polydactyly (HP:0001830)2.02391739
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.9310119
33Dynein arm defect of respiratory motile cilia (HP:0012255)12.6658418
34Absent/shortened dynein arms (HP:0200106)12.6658418
35Tubulointerstitial fibrosis (HP:0005576)1.94823665
36Congenital primary aphakia (HP:0007707)1.92571388
37Gait imbalance (HP:0002141)1.92218491
38Decreased central vision (HP:0007663)1.90591189
39Congenital hepatic fibrosis (HP:0002612)1.90008603
40Polydipsia (HP:0001959)1.77029480
41Abnormal drinking behavior (HP:0030082)1.77029480
42Aplasia/Hypoplasia of the tongue (HP:0010295)1.73715004
43Abnormality of saccadic eye movements (HP:0000570)1.73295005
44Optic nerve hypoplasia (HP:0000609)1.72705575
45Dyschromatopsia (HP:0007641)1.71104151
46Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68392239
47Facial cleft (HP:0002006)1.68332301
48Chronic sinusitis (HP:0011109)1.67273641
49Stage 5 chronic kidney disease (HP:0003774)1.65761294
50Postaxial hand polydactyly (HP:0001162)1.65204283
51Short ribs (HP:0000773)1.64470167
52Median cleft lip (HP:0000161)1.62349510
53Nephrogenic diabetes insipidus (HP:0009806)1.62005247
54Abnormality of renal excretion (HP:0011036)1.61695430
55Genital tract atresia (HP:0001827)1.61234834
56Gonadotropin excess (HP:0000837)1.61156309
57Bile duct proliferation (HP:0001408)1.61052937
58Abnormal biliary tract physiology (HP:0012439)1.61052937
59Abnormality of the renal cortex (HP:0011035)1.59842594
60Aplasia/Hypoplasia of the lens (HP:0008063)1.58685595
61Asymmetric septal hypertrophy (HP:0001670)1.58331798
62Renal dysplasia (HP:0000110)1.56430471
63Cystic liver disease (HP:0006706)1.54810853
64Poor coordination (HP:0002370)1.53793617
65Fibular hypoplasia (HP:0003038)1.52185693
66Abnormal gallbladder physiology (HP:0012438)1.51874839
67Cholecystitis (HP:0001082)1.51874839
68Oculomotor apraxia (HP:0000657)1.51326670
69Abnormality of the dental root (HP:0006486)1.50029504
70Taurodontia (HP:0000679)1.50029504
71Abnormality of permanent molar morphology (HP:0011071)1.50029504
72Heterotopia (HP:0002282)1.49776716
73Vaginal atresia (HP:0000148)1.48787692
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47645335
75Abnormality of ocular smooth pursuit (HP:0000617)1.46852336
76Impaired smooth pursuit (HP:0007772)1.45388834
77Spastic tetraparesis (HP:0001285)1.45286241
78True hermaphroditism (HP:0010459)1.42896989
79Absent frontal sinuses (HP:0002688)1.41941799
80Abnormality of molar morphology (HP:0011070)1.41338381
81Abnormality of molar (HP:0011077)1.41338381
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.40201322
83Chronic hepatic failure (HP:0100626)1.38412463
84Bundle branch block (HP:0011710)1.37070983
85Abnormality of the dental pulp (HP:0006479)1.36617343
86Pancreatic cysts (HP:0001737)1.35538325
87Abnormality of lateral ventricle (HP:0030047)1.32671242
88Choroideremia (HP:0001139)1.30605718
89Abnormality of the lower motor neuron (HP:0002366)1.30194008
90J-shaped sella turcica (HP:0002680)1.29480413
91Double outlet right ventricle (HP:0001719)1.28298750
92Congenital malformation of the right heart (HP:0011723)1.28298750
93Abnormal urine output (HP:0012590)1.27805954
94Supernumerary spleens (HP:0009799)1.26251070
95Deformed sella turcica (HP:0002681)1.25571236
96Easy fatigability (HP:0003388)1.19938769
97Bell-shaped thorax (HP:0001591)1.19177555
98Constricted visual fields (HP:0001133)1.16285406
99Abnormality of dentin (HP:0010299)1.15965072
100Nephroblastoma (Wilms tumor) (HP:0002667)1.15452184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.95130560
2PDK48.95130560
3PDK25.79131617
4TESK14.53437596
5PRKD34.06626918
6ICK3.46630083
7PTK2B2.28862992
8WNK42.13636556
9STK392.10145878
10STK381.66001604
11NEK21.53215669
12PNCK1.27741545
13STK38L1.23979160
14PDK11.22599865
15DYRK1B1.13571162
16TYRO31.12489276
17BRSK21.00251298
18DYRK30.95135269
19LMTK20.93235937
20CHEK20.85768873
21PLK40.85388475
22WEE10.82524944
23STK30.81194980
24TTK0.79792412
25MAPK150.72171144
26PDPK10.69843321
27CCNB10.64843058
28WNK10.61772932
29IRAK10.59346587
30MUSK0.56479385
31PINK10.54021781
32MAP2K60.53401962
33CHEK10.50348945
34EEF2K0.49566681
35BRSK10.47863881
36MAP2K70.46832215
37RIPK40.46236183
38PASK0.45025043
39TESK20.42585281
40CDC70.42313393
41PAK10.37802643
42PLK10.35314229
43ATM0.33152406
44MAP3K60.32864597
45LATS10.31351015
46LATS20.31264918
47ATR0.30148642
48CDK120.28667961
49MARK20.25672174
50PRKCG0.25386204
51NTRK20.24330822
52MARK30.23765588
53ZAP700.23095353
54NEK60.22819626
55TAOK10.22579482
56IRAK20.22386129
57BRAF0.21900061
58MAP3K40.21830976
59PRKAA10.21073471
60MAPKAPK50.19476158
61CAMK1G0.19188945
62PDGFRB0.18857032
63MTOR0.16972295
64CDK150.16183002
65PRKCZ0.15426994
66PAK20.13602252
67RPS6KB10.13315196
68PRKG20.13209574
69CDK180.12887989
70CDK11A0.12262073
71CDK20.11890195
72MAP3K50.11088613
73DDR20.11033359
74AURKA0.10902420
75CSNK2A10.10788308
76STK100.10026641
77CSNK2A20.09911535
78CDK30.09726790
79ACVR1B0.09721018
80CDK10.09295084
81GSK3B0.08851916
82CAMK2A0.08431267
83PIM10.07961620
84MAP3K100.07946998
85STK110.07924369
86PRKCQ0.07859088
87MAPK100.07082271
88CDK140.07055768
89PKN10.06967579
90RPS6KA10.06279232
91YES10.06168574
92CDK60.05332445
93MAPK80.04542072
94PAK60.04526849
95RIPK10.03889997
96DYRK20.03220137
97CAMKK10.02698651
98PRKG10.02685906
99AURKB0.01240899
100PRKACG0.01094305

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.32596230
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.13771833
3Fatty acid biosynthesis_Homo sapiens_hsa000613.98243700
4Pyruvate metabolism_Homo sapiens_hsa006203.36314647
5Pentose phosphate pathway_Homo sapiens_hsa000303.23828811
6Basal transcription factors_Homo sapiens_hsa030223.17111728
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87653279
8Linoleic acid metabolism_Homo sapiens_hsa005912.84966521
9Propanoate metabolism_Homo sapiens_hsa006402.65636726
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.60686779
11Glucagon signaling pathway_Homo sapiens_hsa049222.50666527
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25426570
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.20452727
14Oocyte meiosis_Homo sapiens_hsa041142.05803381
15Glycerolipid metabolism_Homo sapiens_hsa005611.84577564
16Fanconi anemia pathway_Homo sapiens_hsa034601.83375181
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.80185622
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74600944
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.72291220
20Carbon metabolism_Homo sapiens_hsa012001.59914327
21Selenocompound metabolism_Homo sapiens_hsa004501.58380209
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57397936
23Biosynthesis of amino acids_Homo sapiens_hsa012301.53718967
24PPAR signaling pathway_Homo sapiens_hsa033201.52097049
25Renin-angiotensin system_Homo sapiens_hsa046141.51734518
26Mineral absorption_Homo sapiens_hsa049781.51085290
27Ether lipid metabolism_Homo sapiens_hsa005651.37836735
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34450373
29Amphetamine addiction_Homo sapiens_hsa050311.31065003
30Fructose and mannose metabolism_Homo sapiens_hsa000511.29711557
31Fat digestion and absorption_Homo sapiens_hsa049751.23912934
32Dorso-ventral axis formation_Homo sapiens_hsa043201.22090546
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21465457
34RNA transport_Homo sapiens_hsa030131.20794011
35mRNA surveillance pathway_Homo sapiens_hsa030151.19824934
36Huntingtons disease_Homo sapiens_hsa050161.19118528
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15612865
38Purine metabolism_Homo sapiens_hsa002301.15322158
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.14921242
40Cardiac muscle contraction_Homo sapiens_hsa042601.06473949
41Fatty acid metabolism_Homo sapiens_hsa012120.94837149
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92828696
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92698666
44Fatty acid degradation_Homo sapiens_hsa000710.91509380
45Glutathione metabolism_Homo sapiens_hsa004800.88597725
46Renin secretion_Homo sapiens_hsa049240.87418548
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85069675
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78348182
49Antigen processing and presentation_Homo sapiens_hsa046120.77609543
50Cell cycle_Homo sapiens_hsa041100.73971872
51Insulin secretion_Homo sapiens_hsa049110.69631256
52Arachidonic acid metabolism_Homo sapiens_hsa005900.69200117
53Thyroid hormone synthesis_Homo sapiens_hsa049180.68907862
54Hedgehog signaling pathway_Homo sapiens_hsa043400.67157922
55Estrogen signaling pathway_Homo sapiens_hsa049150.66074638
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65337353
57Chemical carcinogenesis_Homo sapiens_hsa052040.63537122
58Inositol phosphate metabolism_Homo sapiens_hsa005620.62531425
59Collecting duct acid secretion_Homo sapiens_hsa049660.61523112
60Long-term potentiation_Homo sapiens_hsa047200.58903352
61Bile secretion_Homo sapiens_hsa049760.56187083
62Homologous recombination_Homo sapiens_hsa034400.54992444
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.54167269
64Lysine degradation_Homo sapiens_hsa003100.53230579
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53219323
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49728322
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49707837
68Systemic lupus erythematosus_Homo sapiens_hsa053220.49699046
69Endocytosis_Homo sapiens_hsa041440.48163065
70AMPK signaling pathway_Homo sapiens_hsa041520.46877749
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.46028157
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45799163
73Calcium signaling pathway_Homo sapiens_hsa040200.45272366
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43473038
75Pancreatic secretion_Homo sapiens_hsa049720.43130863
76Metabolic pathways_Homo sapiens_hsa011000.41425920
77RNA degradation_Homo sapiens_hsa030180.37845997
78Synaptic vesicle cycle_Homo sapiens_hsa047210.36899607
79Taste transduction_Homo sapiens_hsa047420.36117987
80Protein digestion and absorption_Homo sapiens_hsa049740.35881882
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35223801
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34473410
83Salivary secretion_Homo sapiens_hsa049700.32450935
84Legionellosis_Homo sapiens_hsa051340.29796291
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.29082429
86Pyrimidine metabolism_Homo sapiens_hsa002400.28802197
87ABC transporters_Homo sapiens_hsa020100.28554082
88Sulfur metabolism_Homo sapiens_hsa009200.28300168
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28166273
90VEGF signaling pathway_Homo sapiens_hsa043700.26887719
91cAMP signaling pathway_Homo sapiens_hsa040240.26004673
92Gastric acid secretion_Homo sapiens_hsa049710.23435921
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22400324
94Viral carcinogenesis_Homo sapiens_hsa052030.17507596
95Cocaine addiction_Homo sapiens_hsa050300.17001203
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14880550
97Wnt signaling pathway_Homo sapiens_hsa043100.14113598
98N-Glycan biosynthesis_Homo sapiens_hsa005100.12202584
99Tight junction_Homo sapiens_hsa045300.11707870
100Salmonella infection_Homo sapiens_hsa051320.11310684

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