ZCCHC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)3.79801561
2vocalization behavior (GO:0071625)3.73895793
3locomotory exploration behavior (GO:0035641)3.60650241
4embryonic retina morphogenesis in camera-type eye (GO:0060059)3.47853069
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44571240
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42918518
7dendritic spine morphogenesis (GO:0060997)3.37422666
8axonal fasciculation (GO:0007413)3.33204332
9planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31688567
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30965387
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.24019688
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23090287
13neuron cell-cell adhesion (GO:0007158)3.20402233
14establishment of nucleus localization (GO:0040023)3.16860138
15neurotransmitter-gated ion channel clustering (GO:0072578)3.16515072
16regulation of glutamate receptor signaling pathway (GO:1900449)3.15170782
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.12945368
18dendrite morphogenesis (GO:0048813)3.12495979
19paraxial mesoderm development (GO:0048339)3.11026009
20pyrimidine nucleobase catabolic process (GO:0006208)3.10282990
21synaptic vesicle maturation (GO:0016188)3.07594321
22neuron recognition (GO:0008038)3.03426030
23cell migration in hindbrain (GO:0021535)2.94862990
24protein localization to synapse (GO:0035418)2.92674600
25glutamate secretion (GO:0014047)2.90676998
26regulation of synapse structural plasticity (GO:0051823)2.90567865
27positive regulation of synapse maturation (GO:0090129)2.89049886
28cell-cell junction maintenance (GO:0045217)2.80108031
29semaphorin-plexin signaling pathway (GO:0071526)2.78149428
30exploration behavior (GO:0035640)2.77003446
31regulation of axon extension involved in axon guidance (GO:0048841)2.75147889
32central nervous system projection neuron axonogenesis (GO:0021952)2.72060390
33axon extension (GO:0048675)2.68734417
34regulation of neuronal synaptic plasticity (GO:0048168)2.64617959
35regulation of axon guidance (GO:1902667)2.61324520
36nucleobase catabolic process (GO:0046113)2.60213909
37ionotropic glutamate receptor signaling pathway (GO:0035235)2.58048591
38regulation of dendritic spine morphogenesis (GO:0061001)2.56797450
39axon extension involved in axon guidance (GO:0048846)2.55974778
40neuron projection extension involved in neuron projection guidance (GO:1902284)2.55974778
41synaptic transmission, glutamatergic (GO:0035249)2.55796708
42synaptic vesicle exocytosis (GO:0016079)2.55218136
43adherens junction assembly (GO:0034333)2.53885289
44regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53318320
45embryonic camera-type eye morphogenesis (GO:0048596)2.52754647
46postsynaptic membrane organization (GO:0001941)2.51626331
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.51484102
48plasma membrane repair (GO:0001778)2.47968778
49auditory behavior (GO:0031223)2.47860415
50cell communication by electrical coupling (GO:0010644)2.47835046
51negative regulation of fatty acid transport (GO:2000192)2.47487788
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47150698
53regulation of cholesterol homeostasis (GO:2000188)2.46368213
54embryonic foregut morphogenesis (GO:0048617)2.46308219
55regulation of synaptic vesicle exocytosis (GO:2000300)2.46051920
56neurotransmitter secretion (GO:0007269)2.44060346
57sodium ion export (GO:0071436)2.41408569
58negative regulation of axon extension involved in axon guidance (GO:0048843)2.40984737
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40412935
60innervation (GO:0060384)2.39748337
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.39603469
62regulation of establishment of planar polarity (GO:0090175)2.39417354
63glutamate receptor signaling pathway (GO:0007215)2.39275089
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37556758
65negative regulation of catenin import into nucleus (GO:0035414)2.37270884
66neuromuscular process controlling balance (GO:0050885)2.36944307
67dendritic spine organization (GO:0097061)2.34533713
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.33829660
69neural tube development (GO:0021915)2.33198678
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.32716753
71cerebellar Purkinje cell differentiation (GO:0021702)2.32037757
72regulation of bile acid biosynthetic process (GO:0070857)2.31550370
73cell junction maintenance (GO:0034331)2.30936289
74camera-type eye morphogenesis (GO:0048593)2.30374744
75asymmetric protein localization (GO:0008105)2.30040715
76glial cell proliferation (GO:0014009)2.29746044
77neuron-neuron synaptic transmission (GO:0007270)2.28533472
78activation of protein kinase A activity (GO:0034199)2.28006792
79cochlea morphogenesis (GO:0090103)2.27810294
80desmosome organization (GO:0002934)2.27457919
81gastrulation with mouth forming second (GO:0001702)2.26157481
82negative regulation of axon guidance (GO:1902668)2.25832831
83cerebellar Purkinje cell layer development (GO:0021680)2.25806047
84neuron projection extension (GO:1990138)2.25586924
85ephrin receptor signaling pathway (GO:0048013)2.25200672
86regulation of synapse maturation (GO:0090128)2.24776257
87cerebellar granule cell differentiation (GO:0021707)2.24726839
88convergent extension (GO:0060026)2.24173573
89synapse organization (GO:0050808)2.23869317
90gamma-aminobutyric acid transport (GO:0015812)2.23562307
91positive regulation of axon extension (GO:0045773)2.22943128
92histone H3-K9 demethylation (GO:0033169)2.22523510
93neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.22435574
94epithelial cell-cell adhesion (GO:0090136)2.22383113
95lens morphogenesis in camera-type eye (GO:0002089)2.21339292
96proline transport (GO:0015824)2.20808590
97regulation of early endosome to late endosome transport (GO:2000641)2.20352908
98embryonic eye morphogenesis (GO:0048048)2.19695586
99eye morphogenesis (GO:0048592)2.19680036
100skin morphogenesis (GO:0043589)2.16625394
101developmental cell growth (GO:0048588)2.15728291
102apical protein localization (GO:0045176)2.15291946
103regulation of fatty acid beta-oxidation (GO:0031998)2.15009727
104hippo signaling (GO:0035329)2.14986374
105central nervous system neuron axonogenesis (GO:0021955)2.14809705
106cell-substrate adherens junction assembly (GO:0007045)2.14651041
107focal adhesion assembly (GO:0048041)2.14651041
108neuromuscular junction development (GO:0007528)2.13288707
109nucleus localization (GO:0051647)2.13125147
110negative regulation of sodium ion transport (GO:0010766)2.13066942
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.12537681
112non-canonical Wnt signaling pathway (GO:0035567)2.11662274
113cell migration involved in sprouting angiogenesis (GO:0002042)2.11559041
114regulation of synaptic vesicle transport (GO:1902803)2.10350752
115synapse assembly (GO:0007416)2.10241111
116coronary vasculature morphogenesis (GO:0060977)2.09919923
117regulation of dendritic spine development (GO:0060998)2.09880471
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.09781957
119cell communication involved in cardiac conduction (GO:0086065)2.09681693
120neuronal ion channel clustering (GO:0045161)2.08963267
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.08744106
122body morphogenesis (GO:0010171)2.08369135
123negative regulation of axon extension (GO:0030517)2.07952792
124cerebral cortex radially oriented cell migration (GO:0021799)2.07939473
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.07220223
126regulation of neuron migration (GO:2001222)2.07136605
127synaptic vesicle endocytosis (GO:0048488)2.06441928
128mating behavior (GO:0007617)2.06219962
129prepulse inhibition (GO:0060134)2.04630591
130regulation of NFAT protein import into nucleus (GO:0051532)2.04600197
131branching involved in salivary gland morphogenesis (GO:0060445)2.03871953
132regulation of postsynaptic membrane potential (GO:0060078)2.03638734
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.03306394
134myelination in peripheral nervous system (GO:0022011)2.02672031
135peripheral nervous system axon ensheathment (GO:0032292)2.02672031
136regulation of synaptic plasticity (GO:0048167)2.02388618
137presynaptic membrane assembly (GO:0097105)2.02060277
138cardiac myofibril assembly (GO:0055003)2.01926225
139negative regulation of keratinocyte proliferation (GO:0010839)2.01913506
140regulation of female receptivity (GO:0045924)2.01793115
141regulation of synapse organization (GO:0050807)2.01693967
142regulation of nucleobase-containing compound transport (GO:0032239)2.00945430
143SMAD protein signal transduction (GO:0060395)2.00621946
144stress granule assembly (GO:0034063)2.00604321
145protein localization to microtubule (GO:0035372)2.00496123
146protein retention in ER lumen (GO:0006621)1.97865630
147negative regulation of vascular permeability (GO:0043116)1.97634880
148branching involved in mammary gland duct morphogenesis (GO:0060444)1.97498651
149mesenchyme morphogenesis (GO:0072132)1.97438372
150morphogenesis of an epithelial sheet (GO:0002011)1.97315969
151cranial nerve morphogenesis (GO:0021602)1.97268659
152regulation of catenin import into nucleus (GO:0035412)1.97047255
153cellular potassium ion homeostasis (GO:0030007)1.96679112
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.96418566
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.96223929
156basement membrane organization (GO:0071711)1.96005603
157retina vasculature morphogenesis in camera-type eye (GO:0061299)1.95021508
158NLS-bearing protein import into nucleus (GO:0006607)1.94676814
159RNA localization (GO:0006403)1.93485208
160regulation of extracellular matrix disassembly (GO:0010715)1.91683526
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)1.91532010
162regulation of RNA export from nucleus (GO:0046831)1.91467761
163cellular protein complex localization (GO:0034629)1.91464974
164lung epithelium development (GO:0060428)1.90955201
165chondrocyte proliferation (GO:0035988)1.90294507
166establishment or maintenance of bipolar cell polarity (GO:0061245)1.90279771
167establishment or maintenance of apical/basal cell polarity (GO:0035088)1.90279771
168cellular sodium ion homeostasis (GO:0006883)1.90251480
169heart morphogenesis (GO:0003007)1.89759386
170anterior/posterior axis specification, embryo (GO:0008595)1.89492712
171neuron remodeling (GO:0016322)1.89022600
172notochord development (GO:0030903)1.88749436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17986047
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60655923
3GBX2_23144817_ChIP-Seq_PC3_Human2.57857660
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50617315
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50617315
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45061981
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40268761
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.36053198
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35791658
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29013766
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27954215
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.27711984
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19995320
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19090251
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.18867988
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16535091
17DROSHA_22980978_ChIP-Seq_HELA_Human2.08973242
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07203091
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.01418241
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.93818247
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93503056
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79786812
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78247543
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77808252
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.69821700
26CLOCK_20551151_ChIP-Seq_293T_Human1.69471297
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67269103
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65964169
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.62207389
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61732399
31* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60934958
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59594747
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58507520
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55530685
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55272404
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52183115
37* REST_21632747_ChIP-Seq_MESCs_Mouse1.52177433
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51288693
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50826920
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47032983
41AR_21572438_ChIP-Seq_LNCaP_Human1.44503414
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.44039271
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.43304707
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42955698
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.42493951
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.41322046
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.40936676
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40326313
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38686707
50* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37849912
51AHR_22903824_ChIP-Seq_MCF-7_Human1.36700693
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.36585991
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.34369138
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34032085
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33578992
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32416830
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32339832
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.31753329
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.30843487
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30653966
61KDM2B_26808549_Chip-Seq_K562_Human1.29291318
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.28659701
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.27359959
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26574103
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26446731
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25770474
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24839887
68RACK7_27058665_Chip-Seq_MCF-7_Human1.24785670
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24703819
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24631306
71AR_19668381_ChIP-Seq_PC3_Human1.22370612
72* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21089081
73* REST_18959480_ChIP-ChIP_MESCs_Mouse1.20593949
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20553982
75ZNF274_21170338_ChIP-Seq_K562_Hela1.20132746
76* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19409915
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18668815
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16729589
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.15855272
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13635769
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13465944
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.13008304
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12920219
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12263082
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.12011105
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08928566
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.08412570
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08327064
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.07975331
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07818410
91KDM2B_26808549_Chip-Seq_DND41_Human1.07800411
92TP53_16413492_ChIP-PET_HCT116_Human1.07391206
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07022491
94STAT3_23295773_ChIP-Seq_U87_Human1.06595714
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05766204
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.05274442
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05126492
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05046392
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04587687
100* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04503720
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.04011747
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03828851
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02536850
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.02140898
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.01344188
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00594125
107* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99773423
108LXR_22292898_ChIP-Seq_THP-1_Human0.99678681
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99015305
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98507963
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98204073
112FOXM1_23109430_ChIP-Seq_U2OS_Human0.98156543
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98086146
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.97559215
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97112554
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96902561
117TP53_18474530_ChIP-ChIP_U2OS_Human0.95872749
118BCAT_22108803_ChIP-Seq_LS180_Human0.95821511
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95380209
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95275526
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.94887076
122* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94390395
123* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94390395
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94355872
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94214519
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94212798
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93860293
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93765293
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93651897
130ZNF263_19887448_ChIP-Seq_K562_Human0.93392445
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92910704
132AR_21909140_ChIP-Seq_LNCAP_Human0.92774806
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92351676
134* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92309420
135* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90844323
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90564994
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89526103
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89526103
139P300_19829295_ChIP-Seq_ESCs_Human0.89225933
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.88985608
141AR_25329375_ChIP-Seq_VCAP_Human0.88718536
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.88180232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.91874726
2MP0005409_darkened_coat_color3.47438357
3MP0009780_abnormal_chondrocyte_physiolo2.45245015
4MP0004270_analgesia2.44583802
5MP0000566_synostosis2.38954386
6MP0005076_abnormal_cell_differentiation2.35685099
7MP0003635_abnormal_synaptic_transmissio2.35021898
8MP0005257_abnormal_intraocular_pressure2.28491039
9MP0003705_abnormal_hypodermis_morpholog2.08741424
10MP0000778_abnormal_nervous_system2.05229174
11MP0002063_abnormal_learning/memory/cond1.96916858
12MP0005623_abnormal_meninges_morphology1.94573371
13MP0000537_abnormal_urethra_morphology1.90287500
14MP0003283_abnormal_digestive_organ1.88344538
15MP0003122_maternal_imprinting1.84365780
16MP0000751_myopathy1.77928079
17MP0008438_abnormal_cutaneous_collagen1.76383438
18MP0010352_gastrointestinal_tract_polyps1.71119440
19MP0004272_abnormal_basement_membrane1.70735501
20MP0003880_abnormal_central_pattern1.70034451
21MP0009745_abnormal_behavioral_response1.69071899
22MP0005248_abnormal_Harderian_gland1.64211868
23MP0004858_abnormal_nervous_system1.57545320
24MP0004885_abnormal_endolymph1.54528556
25MP0003385_abnormal_body_wall1.54059032
26MP0005187_abnormal_penis_morphology1.53462933
27MP0002822_catalepsy1.51187891
28MP0010368_abnormal_lymphatic_system1.50169785
29MP0005503_abnormal_tendon_morphology1.49611236
30MP0002572_abnormal_emotion/affect_behav1.47163922
31MP0003123_paternal_imprinting1.47069384
32MP0000534_abnormal_ureter_morphology1.44659900
33MP0002064_seizures1.44457562
34MP0002089_abnormal_postnatal_growth/wei1.39493262
35MP0002909_abnormal_adrenal_gland1.35553438
36MP0002837_dystrophic_cardiac_calcinosis1.34824426
37MP0002734_abnormal_mechanical_nocicepti1.32686571
38MP0002184_abnormal_innervation1.32454428
39MP0003787_abnormal_imprinting1.31579592
40MP0000569_abnormal_digit_pigmentation1.31366452
41MP0002697_abnormal_eye_size1.28914382
42MP0010030_abnormal_orbit_morphology1.28407538
43MP0000733_abnormal_muscle_development1.27260944
44MP0001486_abnormal_startle_reflex1.27071216
45MP0003942_abnormal_urinary_system1.23923608
46MP0001299_abnormal_eye_distance/1.23019105
47MP0001849_ear_inflammation1.22210281
48MP0003091_abnormal_cell_migration1.21624757
49MP0001177_atelectasis1.21442645
50MP0000678_abnormal_parathyroid_gland1.19955711
51MP0003115_abnormal_respiratory_system1.19190822
52MP0009046_muscle_twitch1.18331100
53MP0000762_abnormal_tongue_morphology1.17671497
54MP0003119_abnormal_digestive_system1.16000520
55MP0002108_abnormal_muscle_morphology1.14431022
56MP0004085_abnormal_heartbeat1.13076320
57MP0000955_abnormal_spinal_cord1.12829660
58MP0002234_abnormal_pharynx_morphology1.12665740
59MP0003566_abnormal_cell_adhesion1.12496852
60MP0005666_abnormal_adipose_tissue1.11662509
61MP0002557_abnormal_social/conspecific_i1.11270357
62MP0005670_abnormal_white_adipose1.10720038
63MP0005423_abnormal_somatic_nervous1.09956323
64MP0001968_abnormal_touch/_nociception1.08797814
65MP0009053_abnormal_anal_canal1.08678369
66MP0005275_abnormal_skin_tensile1.08218004
67MP0004811_abnormal_neuron_physiology1.07976223
68MP0000462_abnormal_digestive_system1.07376241
69MP0003755_abnormal_palate_morphology1.07144867
70MP0000432_abnormal_head_morphology1.06528660
71MP0004185_abnormal_adipocyte_glucose1.05802887
72MP0009250_abnormal_appendicular_skeleto1.05029153
73MP0002249_abnormal_larynx_morphology1.03837041
74MP0002152_abnormal_brain_morphology1.02072607
75MP0002896_abnormal_bone_mineralization1.01236364
76MP0003861_abnormal_nervous_system1.00860270
77MP0001440_abnormal_grooming_behavior1.00634997
78MP0003868_abnormal_feces_composition0.99844813
79MP0005646_abnormal_pituitary_gland0.99612490
80MP0002882_abnormal_neuron_morphology0.99469213
81MP0000049_abnormal_middle_ear0.98428743
82MP0005375_adipose_tissue_phenotype0.98236912
83MP0002272_abnormal_nervous_system0.98040623
84MP0002092_abnormal_eye_morphology0.97322748
85MP0000003_abnormal_adipose_tissue0.97108249
86MP0009672_abnormal_birth_weight0.96916726
87MP0005508_abnormal_skeleton_morphology0.95175708
88MP0003329_amyloid_beta_deposits0.94568433
89MP0000579_abnormal_nail_morphology0.94277969
90MP0003935_abnormal_craniofacial_develop0.93598017
91MP0002733_abnormal_thermal_nociception0.92699969
92MP0004264_abnormal_extraembryonic_tissu0.92187097
93MP0003453_abnormal_keratinocyte_physiol0.92070408
94MP0005386_behavior/neurological_phenoty0.91719136
95MP0004924_abnormal_behavior0.91719136
96MP0000631_abnormal_neuroendocrine_gland0.91670137
97MP0002114_abnormal_axial_skeleton0.90830696
98MP0002653_abnormal_ependyma_morphology0.90236478
99MP0006138_congestive_heart_failure0.90071154
100MP0003279_aneurysm0.89654433
101MP0002116_abnormal_craniofacial_bone0.88987541
102MP0001666_abnormal_nutrient_absorption0.88868572
103MP0003634_abnormal_glial_cell0.88032109
104MP0002067_abnormal_sensory_capabilities0.87898958
105MP0003890_abnormal_embryonic-extraembry0.86549006
106MP0004233_abnormal_muscle_weight0.86479110
107MP0002932_abnormal_joint_morphology0.86468172
108MP0001502_abnormal_circadian_rhythm0.85855824
109MP0002084_abnormal_developmental_patter0.84896932
110MP0003121_genomic_imprinting0.84084374
111MP0004145_abnormal_muscle_electrophysio0.83783210
112MP0002233_abnormal_nose_morphology0.83581852
113MP0003137_abnormal_impulse_conducting0.83269198
114MP0002139_abnormal_hepatobiliary_system0.83079787
115MP0000013_abnormal_adipose_tissue0.83053467
116MP0002925_abnormal_cardiovascular_devel0.82265153
117MP0002735_abnormal_chemical_nociception0.81755772
118MP0000767_abnormal_smooth_muscle0.81315660
119MP0003879_abnormal_hair_cell0.80813907
120MP0002066_abnormal_motor_capabilities/c0.79954141
121MP0001958_emphysema0.79842959
122MP0010630_abnormal_cardiac_muscle0.79837494
123MP0001879_abnormal_lymphatic_vessel0.79748579
124MP0002085_abnormal_embryonic_tissue0.79693186
125MP0001270_distended_abdomen0.77995844
126MP0010234_abnormal_vibrissa_follicle0.77417605
127MP0003937_abnormal_limbs/digits/tail_de0.76206806
128MP0003252_abnormal_bile_duct0.76206746
129MP0001915_intracranial_hemorrhage0.75950927
130MP0004215_abnormal_myocardial_fiber0.75232843
131MP0005620_abnormal_muscle_contractility0.75081834
132MP0002282_abnormal_trachea_morphology0.73229777
133MP0009703_decreased_birth_body0.73040897
134MP0006276_abnormal_autonomic_nervous0.72894630
135MP0008961_abnormal_basal_metabolism0.72035647
136MP0009384_cardiac_valve_regurgitation0.71989055
137MP0000428_abnormal_craniofacial_morphol0.71857843
138MP0004134_abnormal_chest_morphology0.71706351
139MP0002877_abnormal_melanocyte_morpholog0.70801615
140MP0002098_abnormal_vibrissa_morphology0.70590029
141MP0002295_abnormal_pulmonary_circulatio0.70484660
142MP0004084_abnormal_cardiac_muscle0.70052442
143MP0008569_lethality_at_weaning0.69490494
144MP0003941_abnormal_skin_development0.68346950
145MP0002081_perinatal_lethality0.68241713

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.08182988
2Hepatoblastoma (HP:0002884)2.82740397
3Myokymia (HP:0002411)2.66052445
4Focal seizures (HP:0007359)2.55380540
5Focal motor seizures (HP:0011153)2.53196940
6Ulnar bowing (HP:0003031)2.44913385
7Abnormality of the phalanges of the hallux (HP:0010057)2.44448492
8Protrusio acetabuli (HP:0003179)2.39625910
9Short 4th metacarpal (HP:0010044)2.39413221
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39413221
11Broad face (HP:0000283)2.36960817
12Hyperacusis (HP:0010780)2.36482285
13Broad metatarsal (HP:0001783)2.35056506
14Abnormality of the distal phalanx of the thumb (HP:0009617)2.34321976
15Abnormality of the lower motor neuron (HP:0002366)2.25868415
16Overgrowth (HP:0001548)2.22921109
17Vertebral arch anomaly (HP:0008438)2.18777403
18Lymphangioma (HP:0100764)2.16517494
19Bladder diverticulum (HP:0000015)2.16434244
20Abnormality of the 4th metacarpal (HP:0010012)2.14441806
21Premature rupture of membranes (HP:0001788)2.12714612
22Neonatal short-limb short stature (HP:0008921)2.09406379
23Genetic anticipation (HP:0003743)2.08700745
24Action tremor (HP:0002345)2.05666850
25Turricephaly (HP:0000262)2.02299335
26Bronchomalacia (HP:0002780)2.00522114
27Heterotopia (HP:0002282)1.99791721
28Renovascular hypertension (HP:0100817)1.99512148
29Buphthalmos (HP:0000557)1.99131196
30Megalencephaly (HP:0001355)1.98127762
31Flat acetabular roof (HP:0003180)1.97633306
32Insidious onset (HP:0003587)1.93443772
33Termporal pattern (HP:0011008)1.93443772
34Cerebral aneurysm (HP:0004944)1.93400779
35Aplasia involving bones of the upper limbs (HP:0009823)1.90362961
36Aplasia of the phalanges of the hand (HP:0009802)1.90362961
37Aplasia involving bones of the extremities (HP:0009825)1.90362961
38Renal duplication (HP:0000075)1.89776832
39Excessive salivation (HP:0003781)1.88277684
40Drooling (HP:0002307)1.88277684
41Hyperventilation (HP:0002883)1.86704063
42Epileptic encephalopathy (HP:0200134)1.85985606
43Narrow palate (HP:0000189)1.85479100
44Progressive cerebellar ataxia (HP:0002073)1.85272531
45Cerebral inclusion bodies (HP:0100314)1.84667750
46Increased variability in muscle fiber diameter (HP:0003557)1.84384852
47Wormian bones (HP:0002645)1.82846339
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82506311
49Arnold-Chiari malformation (HP:0002308)1.80049394
50Ankle clonus (HP:0011448)1.79535823
51Thin bony cortex (HP:0002753)1.78600511
52Disproportionate tall stature (HP:0001519)1.78032033
53Visual hallucinations (HP:0002367)1.77506720
54Macroorchidism (HP:0000053)1.77152890
55Germ cell neoplasia (HP:0100728)1.75347956
56Hammertoe (HP:0001765)1.75222003
57Impaired vibration sensation in the lower limbs (HP:0002166)1.75099407
58Coronal craniosynostosis (HP:0004440)1.73999679
59Urinary bladder sphincter dysfunction (HP:0002839)1.73339070
60Lower limb amyotrophy (HP:0007210)1.73154109
61Ankle contracture (HP:0006466)1.73025950
62Atonic seizures (HP:0010819)1.72654521
63Abnormality of the aortic arch (HP:0012303)1.72311785
64Laryngomalacia (HP:0001601)1.72132309
65Torticollis (HP:0000473)1.72020898
66Obstructive sleep apnea (HP:0002870)1.71871513
67Vascular tortuosity (HP:0004948)1.71554425
68Mildly elevated creatine phosphokinase (HP:0008180)1.71414595
69Broad-based gait (HP:0002136)1.70910417
70Midline defect of the nose (HP:0004122)1.69738508
71Abnormality of the corticospinal tract (HP:0002492)1.69059970
72Asymmetry of the thorax (HP:0001555)1.68938643
73Abnormality of the nasal septum (HP:0000419)1.68912370
74Urethral obstruction (HP:0000796)1.68413740
75Shawl scrotum (HP:0000049)1.67923680
76Elfin facies (HP:0004428)1.67586745
77Morphological abnormality of the middle ear (HP:0008609)1.67203837
78Mitral regurgitation (HP:0001653)1.67076649
79Hyperextensible skin (HP:0000974)1.66630191
80Broad palm (HP:0001169)1.66011773
81Dysmetric saccades (HP:0000641)1.65710136
82Hypoventilation (HP:0002791)1.65423542
83Wide anterior fontanel (HP:0000260)1.64954183
84Mitral valve prolapse (HP:0001634)1.64536062
85Arterial tortuosity (HP:0005116)1.63062161
86Atrophic scars (HP:0001075)1.62923564
87Increased connective tissue (HP:0009025)1.61778899
88Dysdiadochokinesis (HP:0002075)1.61597125
89Bowel diverticulosis (HP:0005222)1.59821598
90Aneurysm (HP:0002617)1.59725301
91Papillary thyroid carcinoma (HP:0002895)1.59578635
92Prolonged QT interval (HP:0001657)1.59519064
93Impaired social interactions (HP:0000735)1.59347816
94Abnormal social behavior (HP:0012433)1.59347816
95Long eyelashes (HP:0000527)1.59302415
96Cutaneous finger syndactyly (HP:0010554)1.58503706
97Amblyopia (HP:0000646)1.58446475
98Precocious puberty (HP:0000826)1.57633050
99Exotropia (HP:0000577)1.57420192
100Genu recurvatum (HP:0002816)1.57110000
101Dislocated radial head (HP:0003083)1.56939359
102Advanced eruption of teeth (HP:0006288)1.56801640
103Neoplasm of the heart (HP:0100544)1.56773517
104Aortic aneurysm (HP:0004942)1.56740739
105Abnormal ossification of hand bones (HP:0005921)1.56560870
106Relative macrocephaly (HP:0004482)1.56391777
107Insomnia (HP:0100785)1.56153741
108Subacute progressive viral hepatitis (HP:0006572)1.55949022
109Poor eye contact (HP:0000817)1.55515435
110Tibial bowing (HP:0002982)1.54617478
111Sudden death (HP:0001699)1.53884730
112Increased nuchal translucency (HP:0010880)1.52813250
113Epileptiform EEG discharges (HP:0011182)1.51643830
114Pointed chin (HP:0000307)1.50806489
115Difficulty running (HP:0009046)1.49918355
116Bell-shaped thorax (HP:0001591)1.49813101
117Hypsarrhythmia (HP:0002521)1.49663048
118EEG with generalized epileptiform discharges (HP:0011198)1.48818314
119Abnormality of the radial head (HP:0003995)1.48590224
120Abnormality of carpal bone ossification (HP:0006257)1.48463474
121Joint laxity (HP:0001388)1.48257517
122Type 1 muscle fiber predominance (HP:0003803)1.47559556
123Abnormal ventriculo-arterial connection (HP:0011563)1.47475263
124Transposition of the great arteries (HP:0001669)1.47475263
125Abnormal connection of the cardiac segments (HP:0011545)1.47475263
126Generalized tonic-clonic seizures (HP:0002069)1.47378680
127Lower limb muscle weakness (HP:0007340)1.47317543
128Spinal rigidity (HP:0003306)1.47181046
129Urinary urgency (HP:0000012)1.46899402
130Fragile skin (HP:0001030)1.46810738
131Distal upper limb amyotrophy (HP:0007149)1.46205301
132Upper limb amyotrophy (HP:0009129)1.46205301
133Neurofibrillary tangles (HP:0002185)1.46050329
134Abnormality of dentin (HP:0010299)1.45857503
135Gaze-evoked nystagmus (HP:0000640)1.45281601
136Lower limb asymmetry (HP:0100559)1.44686305
137Biconcave vertebral bodies (HP:0004586)1.44235222
138Aortic dissection (HP:0002647)1.44171065
139Cervical subluxation (HP:0003308)1.44167731
140Broad ribs (HP:0000885)1.43788003
141Hyperparathyroidism (HP:0000843)1.43462853
142Deep venous thrombosis (HP:0002625)1.43224622
143Enlarged penis (HP:0000040)1.42534049
144Thin ribs (HP:0000883)1.42518831
145Facial hemangioma (HP:0000329)1.42349750
146Obsessive-compulsive behavior (HP:0000722)1.42264313
147Flat cornea (HP:0007720)1.42210299
148Choanal stenosis (HP:0000452)1.42150930
149Deviation of the hallux (HP:0010051)1.41883964
150Limited elbow extension (HP:0001377)1.41543454
151Midface retrusion (HP:0011800)1.40414495
152Broad thumb (HP:0011304)1.39674385
153Ankyloglossia (HP:0010296)1.37704087
154Hypercholesterolemia (HP:0003124)1.36675585
155Cutaneous syndactyly (HP:0012725)1.36208030
156Abnormal hand bone ossification (HP:0010660)1.35331436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.37893666
2NTRK33.08078395
3EPHA42.83201573
4EEF2K2.33021875
5MAP3K42.21617875
6LATS22.11537558
7PRKD32.10328819
8DAPK22.08691400
9LATS12.04892511
10EPHB22.03052337
11BRD42.01425952
12FGFR41.97706715
13MAP3K91.90446601
14PRPF4B1.85225425
15MAP3K101.83229707
16ICK1.79389841
17PAK61.78954749
18PDGFRA1.70977196
19KSR11.70463594
20DDR21.67247496
21TYRO31.63985051
22CASK1.59072506
23MINK11.49018791
24NTRK21.48831789
25RIPK11.48037336
26CAMK1G1.37030868
27TRIB31.35659250
28FGFR31.31802182
29MST1R1.28441050
30MAPK131.27116152
31EPHA21.26049799
32FER1.24694378
33NTRK11.24601666
34CAMKK11.22318018
35PTK21.17247641
36AKT31.17009723
37KSR21.16732422
38PAK31.15416529
39MAP2K41.14973739
40SMG11.14491970
41FGFR21.12859750
42PHKG21.09313676
43PHKG11.09313676
44PLK21.07594325
45SGK4941.04619576
46SGK2231.04619576
47PTK2B1.04209701
48MAP3K21.03553197
49CDK51.01619770
50SIK11.01216270
51IRAK30.96059877
52STK380.95116153
53SIK20.94179717
54ERBB30.93230501
55SGK20.91849280
56PRKCH0.91630574
57TTN0.91555628
58DMPK0.91230984
59CAMK1D0.91022878
60CSNK1G20.89469382
61PTK60.89250608
62BCR0.88095980
63RET0.86849357
64MARK20.85819237
65SGK30.85102746
66ROCK10.84931327
67MAP2K70.84092884
68CSNK1A1L0.82475484
69PKN20.81884690
70STK110.81583733
71MELK0.78581385
72CDC42BPA0.78511129
73WNK40.78363780
74UHMK10.76626165
75TIE10.76081375
76PNCK0.75011194
77BMX0.74999264
78TAOK10.74664801
79EPHB10.73127794
80NEK60.70479908
81MAP3K70.69766504
82CAMK2A0.69687813
83MET0.69309242
84FGFR10.69104592
85PRKCG0.68267170
86INSRR0.67206970
87WNK10.66681808
88DYRK20.63428411
89MTOR0.63129707
90PDGFRB0.62790549
91CAMK40.62261552
92MAPK100.61692289
93SGK10.61547584
94ERBB20.61016348
95PDPK10.60722265
96DAPK10.60219990
97LMTK20.58607251
98CDK180.58224413
99MAP2K10.56752275
100CDK150.56559147
101DYRK1A0.56286641
102IRAK20.55535307
103CDK120.55181789
104TNIK0.53696481
105PRKCZ0.53465267
106TAOK20.52706309
107PAK20.51995144
108CDK140.51681746
109RPS6KA20.51105281
110CSNK1G30.50862002
111PRKD20.49581635
112FRK0.49532043
113CSNK1G10.48264937
114DYRK1B0.47922687
115ERBB40.47422085
116STK38L0.47404378
117ROCK20.47388963
118WNK30.47196278
119PRKAA10.47154552
120YES10.47147402
121CDK90.46567248
122NLK0.46335504
123PRKAA20.44497798
124RPS6KC10.43128708
125RPS6KL10.43128708
126GSK3B0.41402182
127BRSK10.39113628
128RPS6KB10.38625672
129MAPK80.37686621
130CDK60.36034426
131CAMK10.35297050
132CDK70.34970009
133MAPK150.34303388
134CSNK1E0.34301327
135NEK20.32114682
136MAP3K60.31127169
137CAMK2B0.30589239
138CDK10.29815850
139MAPK140.29592131

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.07496506
2Circadian entrainment_Homo sapiens_hsa047131.89574681
3GABAergic synapse_Homo sapiens_hsa047271.76902195
4Axon guidance_Homo sapiens_hsa043601.76340853
5Glutamatergic synapse_Homo sapiens_hsa047241.73558113
6Long-term potentiation_Homo sapiens_hsa047201.69749045
7Synaptic vesicle cycle_Homo sapiens_hsa047211.63900601
8Amphetamine addiction_Homo sapiens_hsa050311.60268576
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58137676
10Nitrogen metabolism_Homo sapiens_hsa009101.57204320
11Dopaminergic synapse_Homo sapiens_hsa047281.50484771
12Morphine addiction_Homo sapiens_hsa050321.48270987
13Insulin secretion_Homo sapiens_hsa049111.47622617
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46317383
15Olfactory transduction_Homo sapiens_hsa047401.43692879
16Cocaine addiction_Homo sapiens_hsa050301.42013653
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41063873
18Cholinergic synapse_Homo sapiens_hsa047251.38669044
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37632252
20Dilated cardiomyopathy_Homo sapiens_hsa054141.34804581
21Notch signaling pathway_Homo sapiens_hsa043301.33481842
22Basal cell carcinoma_Homo sapiens_hsa052171.32174094
23Gap junction_Homo sapiens_hsa045401.31202264
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30879264
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30092386
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28340651
27Renin secretion_Homo sapiens_hsa049241.27652571
28Salivary secretion_Homo sapiens_hsa049701.27224622
29MicroRNAs in cancer_Homo sapiens_hsa052061.24588960
30Long-term depression_Homo sapiens_hsa047301.23541050
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22920028
32Butanoate metabolism_Homo sapiens_hsa006501.22837901
33Gastric acid secretion_Homo sapiens_hsa049711.22192733
34Chronic myeloid leukemia_Homo sapiens_hsa052201.21915420
35Type II diabetes mellitus_Homo sapiens_hsa049301.21071983
36Oxytocin signaling pathway_Homo sapiens_hsa049211.20837031
37Hedgehog signaling pathway_Homo sapiens_hsa043401.20295056
38Melanogenesis_Homo sapiens_hsa049161.19684477
39Glioma_Homo sapiens_hsa052141.19337065
40Thyroid cancer_Homo sapiens_hsa052161.17449489
41GnRH signaling pathway_Homo sapiens_hsa049121.17152861
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17060405
43Endometrial cancer_Homo sapiens_hsa052131.15935667
44Dorso-ventral axis formation_Homo sapiens_hsa043201.13666605
45Estrogen signaling pathway_Homo sapiens_hsa049151.13254169
46Hippo signaling pathway_Homo sapiens_hsa043901.11387473
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10397057
48Taste transduction_Homo sapiens_hsa047421.08840071
49Bile secretion_Homo sapiens_hsa049761.08541750
50ECM-receptor interaction_Homo sapiens_hsa045121.06629090
51ErbB signaling pathway_Homo sapiens_hsa040121.04241938
52Prostate cancer_Homo sapiens_hsa052151.03765976
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03524338
54Adherens junction_Homo sapiens_hsa045201.02889747
55Focal adhesion_Homo sapiens_hsa045101.01087660
56Serotonergic synapse_Homo sapiens_hsa047261.00542454
57VEGF signaling pathway_Homo sapiens_hsa043701.00294439
58cAMP signaling pathway_Homo sapiens_hsa040241.00148078
59Circadian rhythm_Homo sapiens_hsa047100.99721177
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98612564
61Inositol phosphate metabolism_Homo sapiens_hsa005620.96662195
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96397498
63Calcium signaling pathway_Homo sapiens_hsa040200.96320141
64Complement and coagulation cascades_Homo sapiens_hsa046100.95395372
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92499539
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92024706
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.91427512
68Non-small cell lung cancer_Homo sapiens_hsa052230.89297984
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89218232
70Tight junction_Homo sapiens_hsa045300.89004705
71FoxO signaling pathway_Homo sapiens_hsa040680.86698617
72Wnt signaling pathway_Homo sapiens_hsa043100.86400700
73Lysine degradation_Homo sapiens_hsa003100.86240247
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.85186064
75Arginine biosynthesis_Homo sapiens_hsa002200.85035380
76Prolactin signaling pathway_Homo sapiens_hsa049170.85020494
77Insulin resistance_Homo sapiens_hsa049310.84899312
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81215631
79Renal cell carcinoma_Homo sapiens_hsa052110.80823679
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80163299
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.79939576
82Protein digestion and absorption_Homo sapiens_hsa049740.79171301
83Vitamin B6 metabolism_Homo sapiens_hsa007500.77239270
84Proteoglycans in cancer_Homo sapiens_hsa052050.75295522
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75256227
86Glucagon signaling pathway_Homo sapiens_hsa049220.74734842
87Rap1 signaling pathway_Homo sapiens_hsa040150.74657416
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73951131
89Small cell lung cancer_Homo sapiens_hsa052220.73652226
90Vitamin digestion and absorption_Homo sapiens_hsa049770.71925926
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71791336
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.70280838
93Ovarian steroidogenesis_Homo sapiens_hsa049130.70058448
94Thyroid hormone synthesis_Homo sapiens_hsa049180.69211810
95Pancreatic cancer_Homo sapiens_hsa052120.67925360
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66969659
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64515307
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63782887
99Fatty acid metabolism_Homo sapiens_hsa012120.63616977
100Pathways in cancer_Homo sapiens_hsa052000.62412415
101Insulin signaling pathway_Homo sapiens_hsa049100.62161119
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.62143471
103Fat digestion and absorption_Homo sapiens_hsa049750.61815908
104Choline metabolism in cancer_Homo sapiens_hsa052310.61556138
105mTOR signaling pathway_Homo sapiens_hsa041500.59532073
106Cardiac muscle contraction_Homo sapiens_hsa042600.58458718
107MAPK signaling pathway_Homo sapiens_hsa040100.58299279
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58256839
109mRNA surveillance pathway_Homo sapiens_hsa030150.58099229
110Ras signaling pathway_Homo sapiens_hsa040140.58092890
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.57984477
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57636451
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57458060
114Bladder cancer_Homo sapiens_hsa052190.56986069
115TGF-beta signaling pathway_Homo sapiens_hsa043500.56822146
116PPAR signaling pathway_Homo sapiens_hsa033200.55741559
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55556805
118AMPK signaling pathway_Homo sapiens_hsa041520.54174486
119Prion diseases_Homo sapiens_hsa050200.53304928
120Amoebiasis_Homo sapiens_hsa051460.53233286
121Colorectal cancer_Homo sapiens_hsa052100.53162848
122Melanoma_Homo sapiens_hsa052180.50769134
123Fatty acid biosynthesis_Homo sapiens_hsa000610.50226606
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.49579295
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48894867
126Pancreatic secretion_Homo sapiens_hsa049720.48818483

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