ZCCHC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)6.05698619
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.67987383
3neuron cell-cell adhesion (GO:0007158)5.15653210
4vocalization behavior (GO:0071625)5.14954424
5presynaptic membrane assembly (GO:0097105)5.12668239
6gamma-aminobutyric acid signaling pathway (GO:0007214)4.86321984
7presynaptic membrane organization (GO:0097090)4.84755022
8regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.84597923
9lung vasculature development (GO:0060426)4.63763051
10protein localization to synapse (GO:0035418)4.52287360
11lung lobe morphogenesis (GO:0060463)4.51087283
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.41855835
13glutamate receptor signaling pathway (GO:0007215)4.36265130
14startle response (GO:0001964)4.35114070
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27387458
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17049426
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.17042430
18positive regulation of muscle hypertrophy (GO:0014742)4.13510718
19positive regulation of cardiac muscle hypertrophy (GO:0010613)4.13510718
20positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.10633927
21exocrine pancreas development (GO:0031017)4.00472341
22postsynaptic membrane organization (GO:0001941)3.96874163
23negative regulation of androgen receptor signaling pathway (GO:0060766)3.94782540
24neuron-neuron synaptic transmission (GO:0007270)3.93338506
25synaptic transmission, glutamatergic (GO:0035249)3.92229597
26positive regulation of smooth muscle cell migration (GO:0014911)3.82272409
27regulation of glutamate receptor signaling pathway (GO:1900449)3.78223447
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.77453205
29opioid receptor signaling pathway (GO:0038003)3.72594025
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72207401
31neurotransmitter-gated ion channel clustering (GO:0072578)3.67043100
32positive regulation of synapse assembly (GO:0051965)3.65137530
33neuron recognition (GO:0008038)3.64082248
34response to histamine (GO:0034776)3.63203101
35lung secretory cell differentiation (GO:0061140)3.60849217
36innervation (GO:0060384)3.57093575
37regulation of synapse maturation (GO:0090128)3.53578380
38righting reflex (GO:0060013)3.53136580
39serotonin receptor signaling pathway (GO:0007210)3.52120043
40cochlea development (GO:0090102)3.48726549
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45705200
42atrial cardiac muscle cell action potential (GO:0086014)3.44699279
43transmission of nerve impulse (GO:0019226)3.40950146
44axonal fasciculation (GO:0007413)3.37693613
45branching involved in prostate gland morphogenesis (GO:0060442)3.31886396
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23064475
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22496101
48extracellular regulation of signal transduction (GO:1900115)3.21201447
49extracellular negative regulation of signal transduction (GO:1900116)3.21201447
50negative regulation of dendrite morphogenesis (GO:0050774)3.19876320
51dopamine transport (GO:0015872)3.18534357
52long-term synaptic potentiation (GO:0060291)3.15793660
53positive regulation of synapse maturation (GO:0090129)3.09895148
54myotube cell development (GO:0014904)3.03830060
55cranial nerve structural organization (GO:0021604)3.02644668
56neuronal action potential propagation (GO:0019227)3.00812444
57inner ear receptor cell development (GO:0060119)3.00518395
58dendritic spine morphogenesis (GO:0060997)3.00179517
59regulation of synapse assembly (GO:0051963)3.00148055
60synaptic vesicle exocytosis (GO:0016079)2.99832342
61glutamate secretion (GO:0014047)2.97635994
62regulation of smooth muscle cell apoptotic process (GO:0034391)2.95058754
63cellular response to ammonium ion (GO:0071242)2.94927653
64nephron epithelium morphogenesis (GO:0072088)2.92762405
65nephron tubule morphogenesis (GO:0072078)2.92762405
66mechanosensory behavior (GO:0007638)2.91972688
67gamma-aminobutyric acid transport (GO:0015812)2.91958874
68behavioral fear response (GO:0001662)2.91139893
69behavioral defense response (GO:0002209)2.91139893
70mesenchymal cell differentiation involved in renal system development (GO:2001012)2.90626784
71mesenchymal cell differentiation involved in kidney development (GO:0072161)2.90626784
72dendrite development (GO:0016358)2.90409324
73synapse assembly (GO:0007416)2.88407713
74negative regulation of dendrite development (GO:2000171)2.88209766
75metanephric mesenchyme development (GO:0072075)2.85643810
76intraciliary transport (GO:0042073)2.85196750
77regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.83452337
78sequestering of extracellular ligand from receptor (GO:0035581)2.81132899
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80661937
80regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80404380
81positive regulation of neurotransmitter secretion (GO:0001956)2.75761287
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.75741571
83regulation of respiratory system process (GO:0044065)2.75724851
84positive regulation of protein import into nucleus, translocation (GO:0033160)2.75075842
85auditory behavior (GO:0031223)2.74722211
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71833558
87protein localization to cilium (GO:0061512)2.71260423
88regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.69417064
89regulation of postsynaptic membrane potential (GO:0060078)2.68368869
90cerebral cortex radially oriented cell migration (GO:0021799)2.67653703
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67247015
92reflex (GO:0060004)2.66816725
93response to auditory stimulus (GO:0010996)2.65419542
94positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.64720693
95regulation of synaptic transmission, GABAergic (GO:0032228)2.63239651
96regulation of synaptic vesicle exocytosis (GO:2000300)2.62369170
97learning (GO:0007612)2.61160172
98facial nerve structural organization (GO:0021612)2.60093377
99fear response (GO:0042596)2.59908700
100sleep (GO:0030431)2.59751676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86335296
2GBX2_23144817_ChIP-Seq_PC3_Human4.10515346
3TAF15_26573619_Chip-Seq_HEK293_Human3.19015839
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93647435
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82010823
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79885365
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77306452
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73643005
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67732944
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.44227039
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42793327
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41883985
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.35964787
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35302983
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28349378
16P300_19829295_ChIP-Seq_ESCs_Human2.28199951
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26519097
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24488116
19FUS_26573619_Chip-Seq_HEK293_Human2.21840481
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20888291
21VDR_22108803_ChIP-Seq_LS180_Human2.19949735
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16460102
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12686677
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12686677
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11422772
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.11328681
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01382506
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00811421
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.98625057
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92478475
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90791640
32REST_21632747_ChIP-Seq_MESCs_Mouse1.82989008
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.80044304
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79846418
35IGF1R_20145208_ChIP-Seq_DFB_Human1.78347950
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.75492217
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73613194
38EWS_26573619_Chip-Seq_HEK293_Human1.72854822
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.70443007
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.70365309
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.69205475
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.67465887
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67268285
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65193286
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64960402
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61885213
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60393005
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57037910
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.53970545
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50721175
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49830536
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49099620
53AR_25329375_ChIP-Seq_VCAP_Human1.48904658
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.48583558
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47624374
56JUN_21703547_ChIP-Seq_K562_Human1.44160856
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42646423
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42223015
59TP53_18474530_ChIP-ChIP_U2OS_Human1.41839772
60ER_23166858_ChIP-Seq_MCF-7_Human1.39474297
61P53_22387025_ChIP-Seq_ESCs_Mouse1.37321810
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36146244
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35577842
64* TCF4_23295773_ChIP-Seq_U87_Human1.35559334
65* RUNX2_22187159_ChIP-Seq_PCA_Human1.33487406
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32964793
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.32044799
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30858286
69AR_21572438_ChIP-Seq_LNCaP_Human1.29091498
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.28183760
71STAT3_23295773_ChIP-Seq_U87_Human1.27560972
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26759272
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26541438
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26541438
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26456755
76DROSHA_22980978_ChIP-Seq_HELA_Human1.26203440
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24918485
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.24453063
79BCAT_22108803_ChIP-Seq_LS180_Human1.22989026
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22344588
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22321044
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20492344
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19698523
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.19584670
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.19408300
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.18625986
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17738221
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.16959240
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16416979
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15904304
91TP53_16413492_ChIP-PET_HCT116_Human1.12856603
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11796067
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10811337
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.10020641
95KDM2B_26808549_Chip-Seq_REH_Human1.09952336
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09384186
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.07835588
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07453929
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05327807
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.04585193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.03389283
2MP0003787_abnormal_imprinting4.06250178
3MP0003123_paternal_imprinting3.98769338
4MP0004859_abnormal_synaptic_plasticity3.37843125
5MP0001188_hyperpigmentation3.09969213
6MP0001968_abnormal_touch/_nociception3.06448110
7MP0002736_abnormal_nociception_after2.89244723
8MP0003635_abnormal_synaptic_transmissio2.79545373
9MP0003122_maternal_imprinting2.75435746
10MP0005171_absent_coat_pigmentation2.71315556
11MP0009745_abnormal_behavioral_response2.67044882
12MP0002163_abnormal_gland_morphology2.66581184
13MP0003121_genomic_imprinting2.60828514
14MP0006292_abnormal_olfactory_placode2.48171011
15MP0002735_abnormal_chemical_nociception2.46021683
16MP0002063_abnormal_learning/memory/cond2.35163601
17MP0002064_seizures2.20653313
18MP0002572_abnormal_emotion/affect_behav2.15928803
19MP0006276_abnormal_autonomic_nervous2.12353497
20MP0009046_muscle_twitch2.10885808
21MP0005646_abnormal_pituitary_gland2.02531761
22MP0001486_abnormal_startle_reflex2.00694074
23MP0002184_abnormal_innervation2.00379020
24MP0003136_yellow_coat_color1.98214464
25MP0005645_abnormal_hypothalamus_physiol1.97513882
26MP0001529_abnormal_vocalization1.96130145
27MP0001502_abnormal_circadian_rhythm1.95542995
28MP0002272_abnormal_nervous_system1.93153332
29MP0002876_abnormal_thyroid_physiology1.92536920
30MP0003941_abnormal_skin_development1.87329312
31MP0001501_abnormal_sleep_pattern1.83304164
32MP0005379_endocrine/exocrine_gland_phen1.80673147
33MP0009697_abnormal_copulation1.73451301
34MP0002938_white_spotting1.70683886
35MP0001440_abnormal_grooming_behavior1.68103234
36MP0002102_abnormal_ear_morphology1.67519459
37MP0000566_synostosis1.63831462
38MP0002557_abnormal_social/conspecific_i1.62319002
39MP0003938_abnormal_ear_development1.61352605
40MP0002734_abnormal_mechanical_nocicepti1.59603627
41MP0003385_abnormal_body_wall1.53983560
42MP0002067_abnormal_sensory_capabilities1.52705234
43MP0000778_abnormal_nervous_system1.52087843
44MP0002638_abnormal_pupillary_reflex1.51126779
45MP0010386_abnormal_urinary_bladder1.49208231
46MP0002733_abnormal_thermal_nociception1.46408964
47MP0003879_abnormal_hair_cell1.44116869
48MP0001970_abnormal_pain_threshold1.41825177
49MP0005386_behavior/neurological_phenoty1.39620856
50MP0004924_abnormal_behavior1.39620856
51MP0004142_abnormal_muscle_tone1.39227136
52MP0001963_abnormal_hearing_physiology1.35308134
53MP0004270_analgesia1.28481191
54MP0004742_abnormal_vestibular_system1.24925987
55MP0001905_abnormal_dopamine_level1.24880942
56MP0008057_abnormal_DNA_replication1.23493350
57MP0001984_abnormal_olfaction1.21923730
58MP0000026_abnormal_inner_ear1.20189412
59MP0005409_darkened_coat_color1.16731492
60MP0001542_abnormal_bone_strength1.09746909
61MP0003315_abnormal_perineum_morphology1.06594240
62MP0005423_abnormal_somatic_nervous1.02710280
63MP0002751_abnormal_autonomic_nervous1.01231270
64MP0004145_abnormal_muscle_electrophysio1.01173333
65MP0002822_catalepsy0.98808221
66MP0008877_abnormal_DNA_methylation0.98057711
67MP0000631_abnormal_neuroendocrine_gland0.98013514
68MP0001485_abnormal_pinna_reflex0.95077602
69MP0004858_abnormal_nervous_system0.93543089
70MP0000015_abnormal_ear_pigmentation0.88788740
71MP0002066_abnormal_motor_capabilities/c0.87646717
72MP0001664_abnormal_digestion0.87485524
73MP0002882_abnormal_neuron_morphology0.86649928
74MP0001177_atelectasis0.86341282
75MP0005248_abnormal_Harderian_gland0.84734412
76MP0004811_abnormal_neuron_physiology0.81356601
77MP0005551_abnormal_eye_electrophysiolog0.81252518
78MP0000681_abnormal_thyroid_gland0.76281860
79MP0000639_abnormal_adrenal_gland0.76035637
80MP0002152_abnormal_brain_morphology0.74962779
81MP0003633_abnormal_nervous_system0.74785715
82MP0001270_distended_abdomen0.74180514
83MP0009379_abnormal_foot_pigmentation0.74154534
84MP0002069_abnormal_eating/drinking_beha0.72931952
85MP0003942_abnormal_urinary_system0.72763966
86MP0009250_abnormal_appendicular_skeleto0.69094325
87MP0003631_nervous_system_phenotype0.66910370
88MP0008569_lethality_at_weaning0.66730526
89MP0009780_abnormal_chondrocyte_physiolo0.66716306
90MP0003119_abnormal_digestive_system0.66092923
91MP0000955_abnormal_spinal_cord0.64990011
92MP0005253_abnormal_eye_physiology0.64837856
93MP0002108_abnormal_muscle_morphology0.64137012
94MP0000372_irregular_coat_pigmentation0.63607491
95MP0005670_abnormal_white_adipose0.60500274
96MP0003959_abnormal_lean_body0.59044550
97MP0003137_abnormal_impulse_conducting0.57989528
98MP0002752_abnormal_somatic_nervous0.57949573
99MP0002837_dystrophic_cardiac_calcinosis0.56520353
100MP0005174_abnormal_tail_pigmentation0.54858909

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.37437682
2Hepatoblastoma (HP:0002884)6.27670465
3Diastasis recti (HP:0001540)5.15663779
4Hyperventilation (HP:0002883)5.14926697
5Nephroblastoma (Wilms tumor) (HP:0002667)3.75045570
6Febrile seizures (HP:0002373)3.65500513
7Fair hair (HP:0002286)3.61094369
8Embryonal renal neoplasm (HP:0011794)3.60567684
9Abnormal hair whorl (HP:0010721)3.59643481
10Enlarged kidneys (HP:0000105)3.55265999
11Neonatal hypoglycemia (HP:0001998)3.53035423
12Abnormality of incisor morphology (HP:0011063)3.48660766
13Epileptic encephalopathy (HP:0200134)3.40612855
14Metaphyseal dysplasia (HP:0100255)3.39599086
15Neoplasm of the adrenal cortex (HP:0100641)3.30001392
16Absent eyebrow (HP:0002223)3.05906437
17Atonic seizures (HP:0010819)3.05282979
18Blue irides (HP:0000635)3.03089730
19Absence seizures (HP:0002121)3.00559169
20Focal seizures (HP:0007359)2.99798930
21Adrenal hypoplasia (HP:0000835)2.94655999
22Absent speech (HP:0001344)2.91465545
23Hypoplastic left heart (HP:0004383)2.89468744
24True hermaphroditism (HP:0010459)2.72793018
25Generalized hypopigmentation of hair (HP:0011358)2.68234021
26Protruding tongue (HP:0010808)2.68094866
27Dialeptic seizures (HP:0011146)2.67872674
28Broad-based gait (HP:0002136)2.64848954
29Chronic hepatic failure (HP:0100626)2.58106080
30Hypoplastic heart (HP:0001961)2.53532695
31Generalized tonic-clonic seizures (HP:0002069)2.49467884
32Visual hallucinations (HP:0002367)2.47983136
33Pancreatic fibrosis (HP:0100732)2.40910653
34Gait imbalance (HP:0002141)2.40497778
35Poor coordination (HP:0002370)2.40060748
36Prostate neoplasm (HP:0100787)2.36605805
37Absent hair (HP:0002298)2.35711320
38Facial cleft (HP:0002006)2.33118661
39Supernumerary spleens (HP:0009799)2.32185713
40Congenital sensorineural hearing impairment (HP:0008527)2.27073211
41Abnormality of the nasal septum (HP:0000419)2.26563337
42Congenital primary aphakia (HP:0007707)2.26425286
43Nephrogenic diabetes insipidus (HP:0009806)2.25284945
44Embryonal neoplasm (HP:0002898)2.23926846
45Abnormality of the columella (HP:0009929)2.23257435
46Medial flaring of the eyebrow (HP:0010747)2.21375704
47Anomalous pulmonary venous return (HP:0010772)2.16154715
48Severe visual impairment (HP:0001141)2.16152200
49Genital tract atresia (HP:0001827)2.15740977
50Action tremor (HP:0002345)2.15440763
51Fetal akinesia sequence (HP:0001989)2.14540221
52Poor eye contact (HP:0000817)2.12012746
53Inability to walk (HP:0002540)2.10138785
54Vaginal atresia (HP:0000148)2.10130559
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.09727648
56Absent/shortened dynein arms (HP:0200106)2.09727648
57Abnormality of the incisor (HP:0000676)2.09611197
58Excessive salivation (HP:0003781)2.09549555
59Drooling (HP:0002307)2.09549555
60Heterochromia iridis (HP:0001100)2.06471627
61Progressive cerebellar ataxia (HP:0002073)2.04286959
62Abnormality of the lacrimal duct (HP:0011481)2.01763128
63Widely spaced teeth (HP:0000687)2.00810679
64Choroideremia (HP:0001139)2.00244779
65White forelock (HP:0002211)1.99557175
66Absent eyelashes (HP:0000561)1.98385798
67Epileptiform EEG discharges (HP:0011182)1.94929890
68Flared iliac wings (HP:0002869)1.94669869
69Nephronophthisis (HP:0000090)1.94358776
70Morphological abnormality of the middle ear (HP:0008609)1.93557498
71Macroglossia (HP:0000158)1.92643158
72Narrow nasal bridge (HP:0000446)1.90489857
73Pancreatic cysts (HP:0001737)1.89362155
74Median cleft lip (HP:0000161)1.88857116
75Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87392111
76Abnormality of the nasolacrimal system (HP:0000614)1.86704905
77Growth hormone deficiency (HP:0000824)1.86251851
78Abnormality of the pulmonary veins (HP:0011718)1.85237721
79Omphalocele (HP:0001539)1.84692851
80Germ cell neoplasia (HP:0100728)1.82961363
81Optic nerve hypoplasia (HP:0000609)1.80677690
82Patchy hypopigmentation of hair (HP:0011365)1.80060224
83Postaxial foot polydactyly (HP:0001830)1.78851599
84Occipital encephalocele (HP:0002085)1.77326781
85Abnormal lung lobation (HP:0002101)1.73901516
86Conical tooth (HP:0000698)1.73721317
87Myelomeningocele (HP:0002475)1.72683828
88Hypothermia (HP:0002045)1.71870379
89Meckel diverticulum (HP:0002245)1.71137581
90Aplasia of the musculature (HP:0100854)1.70934741
91Gaze-evoked nystagmus (HP:0000640)1.70303407
92Cutaneous syndactyly (HP:0012725)1.68871467
93Tubulointerstitial nephritis (HP:0001970)1.66775040
94Short foot (HP:0001773)1.64343392
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.64138612
96Menstrual irregularities (HP:0000858)1.63634968
97Septo-optic dysplasia (HP:0100842)1.63269840
98Preaxial hand polydactyly (HP:0001177)1.61901991
99Abnormal social behavior (HP:0012433)1.61500560
100Impaired social interactions (HP:0000735)1.61500560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.33709353
2CASK4.39073131
3NTRK33.46492666
4MAP2K73.17574944
5RIPK42.97851404
6SIK32.92853907
7AKT32.69867871
8MAP3K42.40832520
9TNIK2.23564668
10MAP3K122.21911914
11PLK22.13403154
12MAPK132.05297300
13BMPR22.04083929
14NUAK11.89219409
15IRAK11.68998135
16KSR11.66780442
17MARK11.49622131
18DAPK21.36156268
19CDK81.35769052
20TNK21.32486994
21SGK21.31659409
22FRK1.29546330
23MINK11.28752025
24BCR1.27911261
25ADRBK21.26565151
26PRKCG1.25066266
27PLK31.24490246
28PRKCE1.23229023
29DAPK11.16152936
30ERBB31.15053237
31BMPR1B1.14945202
32PINK11.13873660
33YES11.11476203
34CAMK2A1.10494317
35WNK31.08531434
36GRK71.05948217
37PRPF4B1.05026790
38CLK11.04387189
39NTRK20.98863775
40MAP2K40.98531599
41MAP3K20.93763952
42DYRK1A0.90405751
43GRK50.87217268
44FER0.86934116
45STK38L0.82229194
46CAMKK10.80683103
47CAMK2B0.79593432
48FES0.78490303
49EIF2AK20.77205360
50NEK60.74311419
51CSNK1G20.72705667
52PTK2B0.71695981
53SGK4940.69987996
54SGK2230.69987996
55CDK30.67452941
56SIK20.67235470
57SGK10.66513904
58PRKCZ0.61831609
59PASK0.59904676
60CDK50.58593872
61IRAK40.58245793
62CAMK40.56714443
63RPS6KB10.54296525
64PAK30.53840587
65CAMK10.53589517
66MAPK70.53441448
67TXK0.53326220
68CSNK1G30.52396634
69MARK30.51851786
70STK240.51646634
71STK380.50960141
72ZAK0.50448181
73PKN10.46578377
74CSNK1A10.44780883
75SGK30.44138913
76ADRBK10.43391008
77IRAK20.43135433
78CAMK2D0.43095032
79EIF2AK30.43009579
80INSRR0.42754497
81EPHA30.42641122
82BRAF0.42066037
83PRKACA0.41587627
84BUB10.40892010
85CHEK20.40169571
86MUSK0.37821747
87PRKCA0.37284473
88RAF10.36445415
89SRPK10.36299578
90FGR0.35902136
91PRKD20.34829483
92IRAK30.33826596
93CCNB10.33819774
94CSNK1A1L0.32953270
95MKNK20.31683667
96CAMK2G0.31486184
97PRKG10.31459627
98MAP3K140.31368598
99CSNK1D0.29469042
100CSNK1G10.29447414

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.69886313
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.08124894
3Morphine addiction_Homo sapiens_hsa050322.98808811
4Amphetamine addiction_Homo sapiens_hsa050312.75096001
5GABAergic synapse_Homo sapiens_hsa047272.68796319
6Circadian entrainment_Homo sapiens_hsa047132.68670551
7Long-term potentiation_Homo sapiens_hsa047202.58934740
8Glutamatergic synapse_Homo sapiens_hsa047242.56086192
9Synaptic vesicle cycle_Homo sapiens_hsa047212.54735235
10Taste transduction_Homo sapiens_hsa047422.54352972
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.51284489
12Long-term depression_Homo sapiens_hsa047302.32601944
13Serotonergic synapse_Homo sapiens_hsa047262.17830715
14Collecting duct acid secretion_Homo sapiens_hsa049662.08638390
15Dopaminergic synapse_Homo sapiens_hsa047281.91151769
16Calcium signaling pathway_Homo sapiens_hsa040201.88360838
17Renin secretion_Homo sapiens_hsa049241.77940400
18Salivary secretion_Homo sapiens_hsa049701.77467042
19Olfactory transduction_Homo sapiens_hsa047401.73487999
20Insulin secretion_Homo sapiens_hsa049111.64311677
21Cocaine addiction_Homo sapiens_hsa050301.44578346
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43820256
23Oxidative phosphorylation_Homo sapiens_hsa001901.38609707
24Ovarian steroidogenesis_Homo sapiens_hsa049131.35779874
25Cholinergic synapse_Homo sapiens_hsa047251.35073600
26cAMP signaling pathway_Homo sapiens_hsa040241.28958998
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26569850
28Oocyte meiosis_Homo sapiens_hsa041141.20698867
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16046834
30Axon guidance_Homo sapiens_hsa043601.12377100
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09293423
32Oxytocin signaling pathway_Homo sapiens_hsa049211.06918130
33Vibrio cholerae infection_Homo sapiens_hsa051101.05965876
34Glioma_Homo sapiens_hsa052141.05531185
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03992070
36Alzheimers disease_Homo sapiens_hsa050101.00615542
37Phototransduction_Homo sapiens_hsa047440.98795417
38Melanoma_Homo sapiens_hsa052180.98134196
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96668264
40Dilated cardiomyopathy_Homo sapiens_hsa054140.94004142
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93493348
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92464242
43Gap junction_Homo sapiens_hsa045400.91025402
44Rheumatoid arthritis_Homo sapiens_hsa053230.90829739
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90303208
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89934321
47Cardiac muscle contraction_Homo sapiens_hsa042600.87562044
48GnRH signaling pathway_Homo sapiens_hsa049120.86939532
49Parkinsons disease_Homo sapiens_hsa050120.85506498
50Huntingtons disease_Homo sapiens_hsa050160.84888572
51Type I diabetes mellitus_Homo sapiens_hsa049400.84576865
52Melanogenesis_Homo sapiens_hsa049160.84563423
53Circadian rhythm_Homo sapiens_hsa047100.81321388
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81080351
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79953606
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79749546
57Gastric acid secretion_Homo sapiens_hsa049710.78492752
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75682448
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75603441
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74809565
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.73557973
62Homologous recombination_Homo sapiens_hsa034400.71259353
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67461024
64African trypanosomiasis_Homo sapiens_hsa051430.67214244
65Fanconi anemia pathway_Homo sapiens_hsa034600.64198373
66Wnt signaling pathway_Homo sapiens_hsa043100.63409265
67Estrogen signaling pathway_Homo sapiens_hsa049150.60853513
68Pancreatic secretion_Homo sapiens_hsa049720.60652766
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59220258
70Prostate cancer_Homo sapiens_hsa052150.52224664
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50818268
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50036512
73Ras signaling pathway_Homo sapiens_hsa040140.49945161
74Hedgehog signaling pathway_Homo sapiens_hsa043400.47620081
75Sphingolipid metabolism_Homo sapiens_hsa006000.44593388
76Cell cycle_Homo sapiens_hsa041100.43231620
77Rap1 signaling pathway_Homo sapiens_hsa040150.42449105
78ErbB signaling pathway_Homo sapiens_hsa040120.40118055
79Glucagon signaling pathway_Homo sapiens_hsa049220.38596884
80FoxO signaling pathway_Homo sapiens_hsa040680.37428292
81Choline metabolism in cancer_Homo sapiens_hsa052310.36625799
82Mineral absorption_Homo sapiens_hsa049780.35487734
83MAPK signaling pathway_Homo sapiens_hsa040100.35257547
84Asthma_Homo sapiens_hsa053100.34744198
85Type II diabetes mellitus_Homo sapiens_hsa049300.33696774
86Purine metabolism_Homo sapiens_hsa002300.33041741
87Autoimmune thyroid disease_Homo sapiens_hsa053200.30711725
88Phagosome_Homo sapiens_hsa041450.28469576
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28186008
90Inositol phosphate metabolism_Homo sapiens_hsa005620.24431879
91p53 signaling pathway_Homo sapiens_hsa041150.24022132
92Alcoholism_Homo sapiens_hsa050340.22074492
93Vitamin digestion and absorption_Homo sapiens_hsa049770.21920368
94Colorectal cancer_Homo sapiens_hsa052100.21781638
95N-Glycan biosynthesis_Homo sapiens_hsa005100.21274806
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20841351
97Thyroid hormone synthesis_Homo sapiens_hsa049180.20099164
98Graft-versus-host disease_Homo sapiens_hsa053320.17623070
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16228069
100Tuberculosis_Homo sapiens_hsa051520.15026803

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