ZCCHC17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.68605854
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.47973641
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.26543281
4ATP synthesis coupled proton transport (GO:0015986)6.26543281
5respiratory electron transport chain (GO:0022904)5.48820785
6electron transport chain (GO:0022900)5.34370772
7chaperone-mediated protein transport (GO:0072321)5.15746263
8protein neddylation (GO:0045116)4.58120134
9neuron cell-cell adhesion (GO:0007158)4.51323613
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.42460806
11protein complex biogenesis (GO:0070271)4.30619388
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22780386
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.22780386
14NADH dehydrogenase complex assembly (GO:0010257)4.22780386
15axon ensheathment in central nervous system (GO:0032291)4.08239661
16central nervous system myelination (GO:0022010)4.08239661
17dopamine transport (GO:0015872)3.99269670
18chromatin remodeling at centromere (GO:0031055)3.76215433
19mitochondrial respiratory chain complex assembly (GO:0033108)3.74894431
20CENP-A containing nucleosome assembly (GO:0034080)3.71742877
21long-chain fatty acid biosynthetic process (GO:0042759)3.71616628
22presynaptic membrane assembly (GO:0097105)3.64856574
23negative regulation of neurotransmitter transport (GO:0051589)3.63301103
24dopamine biosynthetic process (GO:0042416)3.61166518
25gamma-aminobutyric acid signaling pathway (GO:0007214)3.57094119
26hydrogen ion transmembrane transport (GO:1902600)3.56625447
27presynaptic membrane organization (GO:0097090)3.55589596
28ATP hydrolysis coupled proton transport (GO:0015991)3.52243510
29energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52243510
30establishment of integrated proviral latency (GO:0075713)3.50995989
31synapsis (GO:0007129)3.48099991
32neuronal action potential propagation (GO:0019227)3.48092006
33regulation of catecholamine metabolic process (GO:0042069)3.46879615
34regulation of dopamine metabolic process (GO:0042053)3.46879615
35synaptic vesicle exocytosis (GO:0016079)3.43344328
36protein localization to synapse (GO:0035418)3.41321700
37substantia nigra development (GO:0021762)3.36436259
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35346309
39GTP biosynthetic process (GO:0006183)3.33925250
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32605305
41histone exchange (GO:0043486)3.30521844
42inner mitochondrial membrane organization (GO:0007007)3.29506577
43neuron recognition (GO:0008038)3.28692206
44proton transport (GO:0015992)3.27182830
45protein deneddylation (GO:0000338)3.20511719
46hydrogen transport (GO:0006818)3.18044340
47regulation of protein kinase A signaling (GO:0010738)3.15450453
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15053032
49positive regulation of synapse assembly (GO:0051965)3.14267142
50transmission of nerve impulse (GO:0019226)3.13481410
51transferrin transport (GO:0033572)3.12603426
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12135054
53regulation of glutamate secretion (GO:0014048)3.11586970
54neurotransmitter uptake (GO:0001504)3.10799378
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09249134
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08599861
57synaptic transmission, dopaminergic (GO:0001963)3.08403397
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03956086
59proteasome assembly (GO:0043248)3.03801211
60fatty acid elongation (GO:0030497)3.02798726
61ATP biosynthetic process (GO:0006754)3.02198816
62vocalization behavior (GO:0071625)3.02179739
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01653121
64glutamate receptor signaling pathway (GO:0007215)3.01217730
65resolution of meiotic recombination intermediates (GO:0000712)3.00929276
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99320750
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97637097
68negative regulation of ligase activity (GO:0051352)2.97637097
69neuron-neuron synaptic transmission (GO:0007270)2.95923548
70DNA damage response, detection of DNA damage (GO:0042769)2.93876056
71protein targeting to mitochondrion (GO:0006626)2.92522805
72sequestering of actin monomers (GO:0042989)2.91857050
73establishment of protein localization to mitochondrion (GO:0072655)2.91749779
74protein localization to cilium (GO:0061512)2.90828142
75chromosome organization involved in meiosis (GO:0070192)2.89039833
76regulation of mitochondrial translation (GO:0070129)2.88318586
77regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.86847166
78replication fork processing (GO:0031297)2.85636092
79DNA replication-independent nucleosome organization (GO:0034724)2.85621619
80DNA replication-independent nucleosome assembly (GO:0006336)2.85621619
81behavioral response to cocaine (GO:0048148)2.85558646
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.84714424
83platelet dense granule organization (GO:0060155)2.84315539
84ferric iron transport (GO:0015682)2.83572928
85trivalent inorganic cation transport (GO:0072512)2.83572928
86meiosis I (GO:0007127)2.83135331
87male meiosis I (GO:0007141)2.81323478
88translational termination (GO:0006415)2.80120035
89regulation of meiosis I (GO:0060631)2.79881867
90ribosomal large subunit biogenesis (GO:0042273)2.79310899
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79216561
92regulation of mitotic spindle checkpoint (GO:1903504)2.79216561
93ribosomal small subunit assembly (GO:0000028)2.79025521
94rRNA modification (GO:0000154)2.77921864
95viral transcription (GO:0019083)2.77210687
96DNA replication checkpoint (GO:0000076)2.76938068
97establishment of viral latency (GO:0019043)2.76706900
98DNA double-strand break processing (GO:0000729)2.76296855
99cotranslational protein targeting to membrane (GO:0006613)2.76290468
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75572909
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75457435
102regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75280817
103calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74034239
104respiratory chain complex IV assembly (GO:0008535)2.73879677
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73549492
106negative regulation of appetite (GO:0032099)2.73052020
107negative regulation of response to food (GO:0032096)2.73052020
108protein localization to mitochondrion (GO:0070585)2.72514126
109intraciliary transport (GO:0042073)2.72299132
110intracellular protein transmembrane import (GO:0044743)2.71990070
111positive regulation of response to oxidative stress (GO:1902884)2.71523562
112positive regulation of cellular response to oxidative stress (GO:1900409)2.71523562
113protein targeting to ER (GO:0045047)2.70292713
114DNA ligation (GO:0006266)2.69544340
115spliceosomal snRNP assembly (GO:0000387)2.68541418
116righting reflex (GO:0060013)2.68091855
117centriole replication (GO:0007099)2.67719801
118catecholamine transport (GO:0051937)2.67322143
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65591497
120ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65354810
121telomere maintenance via semi-conservative replication (GO:0032201)2.64565852
122synaptic transmission, glutamatergic (GO:0035249)2.63309119
123RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62964332
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62964332
125UTP biosynthetic process (GO:0006228)2.62717460
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62462733
127termination of RNA polymerase III transcription (GO:0006386)2.62156794
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.62156794
129cullin deneddylation (GO:0010388)2.61716071
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61667738
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61667738
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61667738
133translation (GO:0006412)2.61391744
134cellular component biogenesis (GO:0044085)2.61114249
135protein localization to endoplasmic reticulum (GO:0070972)2.60568890
136phagosome maturation (GO:0090382)2.60277313
137kinetochore assembly (GO:0051382)2.60019600
138positive regulation of ligase activity (GO:0051351)2.60003870
139regulation of synaptic vesicle exocytosis (GO:2000300)2.60003250
140maturation of SSU-rRNA (GO:0030490)2.59866704
141axonal fasciculation (GO:0007413)2.58985233
142positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.57650818
143signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57472612
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57472612
145positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56353835
146ribosomal small subunit biogenesis (GO:0042274)2.56294541
147cytochrome complex assembly (GO:0017004)2.56253082
148water-soluble vitamin biosynthetic process (GO:0042364)2.56231966
149DNA strand elongation involved in DNA replication (GO:0006271)2.55928185
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55812808
151regulation of cilium movement (GO:0003352)2.54642275
1527-methylguanosine mRNA capping (GO:0006370)2.54506919
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53912754
154dendrite development (GO:0016358)2.52188394
155cellular response to epinephrine stimulus (GO:0071872)2.52127102
156transcription-coupled nucleotide-excision repair (GO:0006283)2.51604574
157startle response (GO:0001964)2.49569706
158regulation of cellular amino acid metabolic process (GO:0006521)2.49332005
159response to epinephrine (GO:0071871)2.48333076
160guanosine-containing compound biosynthetic process (GO:1901070)2.45933074
161glycerophospholipid catabolic process (GO:0046475)2.45905651
162regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.45435673
163regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.45435673
164response to histamine (GO:0034776)2.45316017
165protein-cofactor linkage (GO:0018065)2.45194842
166negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.44449701
1677-methylguanosine RNA capping (GO:0009452)2.43643106
168RNA capping (GO:0036260)2.43643106
169positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43371408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74272867
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00107687
3GBX2_23144817_ChIP-Seq_PC3_Human3.37662214
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13465664
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95717819
6TAF15_26573619_Chip-Seq_HEK293_Human2.92407342
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83453388
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67877201
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54154662
10VDR_22108803_ChIP-Seq_LS180_Human2.54035159
11E2F7_22180533_ChIP-Seq_HELA_Human2.49909733
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44345318
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39605741
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.36518262
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36296525
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31214190
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.29724215
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16524698
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08447915
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07636171
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.06661512
22VDR_23849224_ChIP-Seq_CD4+_Human2.02742502
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01339658
24FUS_26573619_Chip-Seq_HEK293_Human1.95784320
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95239735
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93823391
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.90545376
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90475833
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87391018
30MYC_18940864_ChIP-ChIP_HL60_Human1.86668197
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80760313
32FOXP3_21729870_ChIP-Seq_TREG_Human1.79219127
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.79003812
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78968085
35REST_21632747_ChIP-Seq_MESCs_Mouse1.78803084
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78488783
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76838670
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75081159
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74460308
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73092251
41P300_19829295_ChIP-Seq_ESCs_Human1.72755745
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.70402566
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70026022
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68840339
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.66989212
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66667784
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66503730
48ER_23166858_ChIP-Seq_MCF-7_Human1.65342921
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62477670
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62477670
51TTF2_22483619_ChIP-Seq_HELA_Human1.60458576
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59223554
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57609293
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53801370
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51992557
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51817852
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50668809
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50646467
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50237795
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49631811
61DCP1A_22483619_ChIP-Seq_HELA_Human1.49246352
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48804751
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46986098
64GABP_19822575_ChIP-Seq_HepG2_Human1.44855227
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44566788
66RNF2_27304074_Chip-Seq_NSC_Mouse1.41291952
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.40173998
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39986903
69* XRN2_22483619_ChIP-Seq_HELA_Human1.39289871
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.39165304
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38918991
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38378578
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37787154
74AR_21572438_ChIP-Seq_LNCaP_Human1.37735217
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.37614846
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37548784
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37520390
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35484605
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33610546
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.33049213
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32641111
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32366478
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.30260452
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29607700
85SMAD4_21799915_ChIP-Seq_A2780_Human1.28973187
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27857682
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27729091
88* EWS_26573619_Chip-Seq_HEK293_Human1.27265173
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26027863
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25150649
91ZNF274_21170338_ChIP-Seq_K562_Hela1.23567852
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.23494703
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23029933
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20974133
95JUN_21703547_ChIP-Seq_K562_Human1.19594890
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.18255199
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16670634
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16146170
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16024679
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15353070
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.14276716
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13797914
103HTT_18923047_ChIP-ChIP_STHdh_Human1.13702694
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11712471
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.11125070
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10737138
107IRF1_19129219_ChIP-ChIP_H3396_Human1.10553482
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09704860
109TP53_22573176_ChIP-Seq_HFKS_Human1.07373846
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05494472
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.05183685
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04016417
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03681055
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02720316
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01710119
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00640546
117* SRF_21415370_ChIP-Seq_HL-1_Mouse1.00407335
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99918435
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.98580348
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.98236814
121RARB_27405468_Chip-Seq_BRAIN_Mouse0.98040108
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97651923
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96578442
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96488091
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94886071
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94352120
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93676159
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.93217900
129P53_22387025_ChIP-Seq_ESCs_Mouse0.93007177
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92962605
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92884153
132E2F1_21310950_ChIP-Seq_MCF-7_Human0.92685797
133RUNX2_22187159_ChIP-Seq_PCA_Human0.92573057
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92411865
135ELK1_19687146_ChIP-ChIP_HELA_Human0.91878663
136AR_25329375_ChIP-Seq_VCAP_Human0.91827766
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.91681206
138P300_18555785_Chip-Seq_ESCs_Mouse0.91051971
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.91010235
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.90282613
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90056402
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88298201
143NANOG_19829295_ChIP-Seq_ESCs_Human0.85507784
144SOX2_19829295_ChIP-Seq_ESCs_Human0.85507784
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83119585
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79269293
147CBP_20019798_ChIP-Seq_JUKART_Human0.79269293
148* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77468210
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.76884116
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76884116
151* KDM5A_27292631_Chip-Seq_BREAST_Human0.76373290
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76319693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.85763551
2MP0001529_abnormal_vocalization3.72892113
3MP0004859_abnormal_synaptic_plasticity3.14563911
4MP0008058_abnormal_DNA_repair3.09331772
5MP0006276_abnormal_autonomic_nervous3.01915370
6MP0001905_abnormal_dopamine_level2.94136287
7MP0003635_abnormal_synaptic_transmissio2.83844952
8MP0001968_abnormal_touch/_nociception2.80213282
9MP0009745_abnormal_behavioral_response2.76401579
10MP0002064_seizures2.73372694
11MP0002736_abnormal_nociception_after2.67137586
12MP0009046_muscle_twitch2.63183826
13MP0002272_abnormal_nervous_system2.54659637
14MP0004270_analgesia2.51776949
15MP0001440_abnormal_grooming_behavior2.44529072
16MP0002572_abnormal_emotion/affect_behav2.34118571
17MP0002063_abnormal_learning/memory/cond2.28397611
18MP0002735_abnormal_chemical_nociception2.24490610
19MP0002734_abnormal_mechanical_nocicepti2.23815966
20MP0004142_abnormal_muscle_tone2.22203846
21MP0001486_abnormal_startle_reflex2.21236228
22MP0008789_abnormal_olfactory_epithelium2.15557598
23MP0005423_abnormal_somatic_nervous2.09747134
24MP0002938_white_spotting2.03685600
25MP0001501_abnormal_sleep_pattern2.00859322
26MP0010094_abnormal_chromosome_stability1.94175162
27MP0002067_abnormal_sensory_capabilities1.92048322
28MP0001188_hyperpigmentation1.90844955
29MP0001970_abnormal_pain_threshold1.88280636
30MP0005409_darkened_coat_color1.86854539
31MP0000778_abnormal_nervous_system1.82870747
32MP0002733_abnormal_thermal_nociception1.82138246
33MP0003693_abnormal_embryo_hatching1.81772915
34MP0005386_behavior/neurological_phenoty1.78361447
35MP0004924_abnormal_behavior1.78361447
36MP0003136_yellow_coat_color1.75863958
37MP0008932_abnormal_embryonic_tissue1.71779024
38MP0009379_abnormal_foot_pigmentation1.71490241
39MP0003329_amyloid_beta_deposits1.69413748
40MP0004957_abnormal_blastocyst_morpholog1.69354403
41MP0002837_dystrophic_cardiac_calcinosis1.66811286
42MP0004742_abnormal_vestibular_system1.65314873
43MP0000920_abnormal_myelination1.58743791
44MP0002184_abnormal_innervation1.57316069
45MP0002160_abnormal_reproductive_system1.53558323
46MP0001984_abnormal_olfaction1.51550289
47MP0002822_catalepsy1.50153403
48MP0001293_anophthalmia1.49808705
49MP0004145_abnormal_muscle_electrophysio1.46309605
50MP0003077_abnormal_cell_cycle1.43807180
51MP0010030_abnormal_orbit_morphology1.42523180
52MP0003111_abnormal_nucleus_morphology1.42221081
53MP0002210_abnormal_sex_determination1.41679566
54MP0003186_abnormal_redox_activity1.40999350
55MP0005551_abnormal_eye_electrophysiolog1.39696992
56MP0005084_abnormal_gallbladder_morpholo1.38907092
57MP0005171_absent_coat_pigmentation1.38879425
58MP0003122_maternal_imprinting1.38751517
59MP0003890_abnormal_embryonic-extraembry1.37923705
60MP0002557_abnormal_social/conspecific_i1.35931250
61MP0005646_abnormal_pituitary_gland1.32896460
62MP0002066_abnormal_motor_capabilities/c1.28681842
63MP0001929_abnormal_gametogenesis1.28542268
64MP0002876_abnormal_thyroid_physiology1.28039462
65MP0002882_abnormal_neuron_morphology1.27723230
66MP0002163_abnormal_gland_morphology1.27714989
67MP0010386_abnormal_urinary_bladder1.23650654
68MP0003123_paternal_imprinting1.21563938
69MP0003806_abnormal_nucleotide_metabolis1.21425880
70MP0002234_abnormal_pharynx_morphology1.21419936
71MP0000049_abnormal_middle_ear1.20719850
72MP0002229_neurodegeneration1.20681332
73MP0002102_abnormal_ear_morphology1.20593451
74MP0004147_increased_porphyrin_level1.19925976
75MP0005645_abnormal_hypothalamus_physiol1.19090998
76MP0005379_endocrine/exocrine_gland_phen1.18335833
77MP0008007_abnormal_cellular_replicative1.16219331
78MP0006072_abnormal_retinal_apoptosis1.15078879
79MP0003698_abnormal_male_reproductive1.15061723
80MP0000955_abnormal_spinal_cord1.14761752
81MP0002638_abnormal_pupillary_reflex1.14752831
82MP0001963_abnormal_hearing_physiology1.14343267
83MP0009697_abnormal_copulation1.14093174
84MP0001485_abnormal_pinna_reflex1.12257980
85MP0001986_abnormal_taste_sensitivity1.11732232
86MP0006292_abnormal_olfactory_placode1.08840776
87MP0004133_heterotaxia1.07524490
88MP0002752_abnormal_somatic_nervous1.07371818
89MP0000653_abnormal_sex_gland1.06810516
90MP0002233_abnormal_nose_morphology1.06763367
91MP0003787_abnormal_imprinting1.06705561
92MP0003011_delayed_dark_adaptation1.06692033
93MP0008569_lethality_at_weaning1.06141455
94MP0001145_abnormal_male_reproductive1.05417958
95MP0000631_abnormal_neuroendocrine_gland1.03317314
96MP0003941_abnormal_skin_development1.01280633
97MP0008995_early_reproductive_senescence1.01082100
98MP0000566_synostosis1.00865442
99MP0008260_abnormal_autophagy1.00238869
100MP0005389_reproductive_system_phenotype0.99893463
101MP0000026_abnormal_inner_ear0.99841795
102MP0003937_abnormal_limbs/digits/tail_de0.97636075
103MP0001727_abnormal_embryo_implantation0.96353598
104MP0002653_abnormal_ependyma_morphology0.93701915
105MP0005187_abnormal_penis_morphology0.90015141
106MP0004811_abnormal_neuron_physiology0.89067187
107MP0000751_myopathy0.88528896
108MP0006036_abnormal_mitochondrial_physio0.87303788
109MP0006035_abnormal_mitochondrial_morpho0.87069189
110MP0000647_abnormal_sebaceous_gland0.85370851
111MP0001664_abnormal_digestion0.85312762
112MP0003634_abnormal_glial_cell0.85305512
113MP0002152_abnormal_brain_morphology0.84307367
114MP0005410_abnormal_fertilization0.83402108
115MP0001286_abnormal_eye_development0.82424716
116MP0002751_abnormal_autonomic_nervous0.81000211
117MP0003632_abnormal_nervous_system0.80817768
118MP0003879_abnormal_hair_cell0.80410003
119MP0000372_irregular_coat_pigmentation0.80199179
120MP0003631_nervous_system_phenotype0.79531140
121MP0008877_abnormal_DNA_methylation0.79356046
122MP0008872_abnormal_physiological_respon0.78303995
123MP0005253_abnormal_eye_physiology0.77743235
124MP0001502_abnormal_circadian_rhythm0.76304373
125MP0003718_maternal_effect0.75680489
126MP0003938_abnormal_ear_development0.74593277
127MP0004215_abnormal_myocardial_fiber0.71543047
128MP0003121_genomic_imprinting0.71187454
129MP0003137_abnormal_impulse_conducting0.69821430
130MP0004885_abnormal_endolymph0.69323474
131MP0003315_abnormal_perineum_morphology0.67405138
132MP0000013_abnormal_adipose_tissue0.64814957
133MP0004484_altered_response_of0.64718362
134MP0003633_abnormal_nervous_system0.63862430
135MP0002069_abnormal_eating/drinking_beha0.63604628
136MP0005535_abnormal_body_temperature0.62874821
137MP0004085_abnormal_heartbeat0.62470569
138MP0005499_abnormal_olfactory_system0.61347754
139MP0005394_taste/olfaction_phenotype0.61347754

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.96661302
2Mitochondrial inheritance (HP:0001427)5.48560634
3Abnormal mitochondria in muscle tissue (HP:0008316)5.30239074
4Progressive macrocephaly (HP:0004481)5.13030735
5Hepatocellular necrosis (HP:0001404)4.77884371
6Acute encephalopathy (HP:0006846)4.58120250
7Increased CSF lactate (HP:0002490)4.54009908
8Increased hepatocellular lipid droplets (HP:0006565)4.50878637
9Renal Fanconi syndrome (HP:0001994)4.25298036
10Focal motor seizures (HP:0011153)4.11737600
11Lipid accumulation in hepatocytes (HP:0006561)3.76454682
12Hepatic necrosis (HP:0002605)3.73754257
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.53879189
14Abnormality of glycolysis (HP:0004366)3.50364375
15Increased serum pyruvate (HP:0003542)3.50364375
16Optic disc pallor (HP:0000543)3.38855817
17Leukodystrophy (HP:0002415)3.38476774
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34287969
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.22648548
20Abnormality of the labia minora (HP:0012880)3.20404230
21Increased intramyocellular lipid droplets (HP:0012240)3.19845896
22Atonic seizures (HP:0010819)3.18704790
23Respiratory failure (HP:0002878)3.14575978
24Myokymia (HP:0002411)3.03407037
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01075264
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.01075264
27Exercise intolerance (HP:0003546)2.96147030
28Delusions (HP:0000746)2.93480928
293-Methylglutaconic aciduria (HP:0003535)2.89294844
30Exertional dyspnea (HP:0002875)2.84139020
31Abnormality of renal resorption (HP:0011038)2.83062554
32Parakeratosis (HP:0001036)2.80732544
33Cerebral hypomyelination (HP:0006808)2.80253306
34Medial flaring of the eyebrow (HP:0010747)2.78710263
35Limb dystonia (HP:0002451)2.75644359
36Increased serum lactate (HP:0002151)2.75298880
37Cerebral edema (HP:0002181)2.70311023
38Septo-optic dysplasia (HP:0100842)2.69166865
39Lactic acidosis (HP:0003128)2.68675339
40Reticulocytopenia (HP:0001896)2.67068328
41Epileptic encephalopathy (HP:0200134)2.66064106
42Abnormal hair whorl (HP:0010721)2.65747417
43Gait imbalance (HP:0002141)2.63469172
44Broad-based gait (HP:0002136)2.62279903
45Neurofibrillary tangles (HP:0002185)2.60437214
46Pancreatic fibrosis (HP:0100732)2.59084007
47Neuroendocrine neoplasm (HP:0100634)2.58423594
48Hypothermia (HP:0002045)2.51525934
49Pheochromocytoma (HP:0002666)2.48320665
50Focal seizures (HP:0007359)2.48124594
51Congenital primary aphakia (HP:0007707)2.47702592
52Molar tooth sign on MRI (HP:0002419)2.46640094
53Abnormality of midbrain morphology (HP:0002418)2.46640094
54Respiratory difficulties (HP:0002880)2.45630582
55Absence seizures (HP:0002121)2.43566729
56Cerebral inclusion bodies (HP:0100314)2.43400171
57Emotional lability (HP:0000712)2.43202345
58Hyperventilation (HP:0002883)2.43097881
59Increased muscle lipid content (HP:0009058)2.43078470
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41639227
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41639227
62Pancreatic cysts (HP:0001737)2.38425061
63Visual hallucinations (HP:0002367)2.37665443
64Abnormality of cells of the erythroid lineage (HP:0012130)2.37086307
65Dialeptic seizures (HP:0011146)2.36298011
66Hyperglycinemia (HP:0002154)2.36079890
67Abnormal number of erythroid precursors (HP:0012131)2.33853501
68X-linked dominant inheritance (HP:0001423)2.29819652
69Absent septum pellucidum (HP:0001331)2.25234075
70Nephrogenic diabetes insipidus (HP:0009806)2.24527218
71Macrocytic anemia (HP:0001972)2.24055400
72Genital tract atresia (HP:0001827)2.20830613
73Optic nerve hypoplasia (HP:0000609)2.20688858
74Febrile seizures (HP:0002373)2.18587182
75Retinal dysplasia (HP:0007973)2.18262905
76Vaginal atresia (HP:0000148)2.17677481
77Abnormal pupillary function (HP:0007686)2.16017552
78Esotropia (HP:0000565)2.13831718
79Progressive inability to walk (HP:0002505)2.12748037
80CNS hypomyelination (HP:0003429)2.12640857
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12255495
82True hermaphroditism (HP:0010459)2.12096181
83Polyphagia (HP:0002591)2.11374215
84Abnormal ciliary motility (HP:0012262)2.09981154
85Median cleft lip (HP:0000161)2.09961283
86CNS demyelination (HP:0007305)2.08578147
87Abnormality of the corticospinal tract (HP:0002492)2.04690742
88Sensory axonal neuropathy (HP:0003390)2.04068150
89Oligodactyly (hands) (HP:0001180)2.02243497
90Dysmetria (HP:0001310)2.01066019
91Generalized tonic-clonic seizures (HP:0002069)2.00850366
92Colon cancer (HP:0003003)1.99851752
93Generalized aminoaciduria (HP:0002909)1.99601013
94Meckel diverticulum (HP:0002245)1.98751835
95Nephronophthisis (HP:0000090)1.95557732
96Lethargy (HP:0001254)1.94514183
97Congenital ichthyosiform erythroderma (HP:0007431)1.93323247
98Abnormality of the septum pellucidum (HP:0007375)1.92946354
99Cerebral hemorrhage (HP:0001342)1.92407245
100Progressive cerebellar ataxia (HP:0002073)1.92042481
101Sclerocornea (HP:0000647)1.91437881
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.87919181
103Anxiety (HP:0000739)1.86840365
104Abnormality of the ileum (HP:0001549)1.86120739
105Amblyopia (HP:0000646)1.85903915
106Aplastic anemia (HP:0001915)1.84563408
107Methylmalonic aciduria (HP:0012120)1.83589778
108Abnormality of serum amino acid levels (HP:0003112)1.83402679
109Poor suck (HP:0002033)1.83334031
110Supernumerary spleens (HP:0009799)1.82968986
111Abnormal respiratory motile cilium morphology (HP:0005938)1.81710442
112Abnormal respiratory epithelium morphology (HP:0012253)1.81710442
113Absent/shortened dynein arms (HP:0200106)1.81635619
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.81635619
115Supranuclear gaze palsy (HP:0000605)1.81488036
116Hyperphosphaturia (HP:0003109)1.80322425
117Type I transferrin isoform profile (HP:0003642)1.79607797
118Spastic gait (HP:0002064)1.79167150
119Stenosis of the external auditory canal (HP:0000402)1.78711208
120Abnormal respiratory motile cilium physiology (HP:0012261)1.77570002
121Abnormality of methionine metabolism (HP:0010901)1.77451804
122Abnormal lung lobation (HP:0002101)1.77262126
123Abnormality of urine glucose concentration (HP:0011016)1.74728209
124Glycosuria (HP:0003076)1.74728209
125Postnatal microcephaly (HP:0005484)1.74177513
126Gaze-evoked nystagmus (HP:0000640)1.74159737
127Methylmalonic acidemia (HP:0002912)1.74097390
128Inability to walk (HP:0002540)1.73682497
129Type II lissencephaly (HP:0007260)1.72924521
130Unsteady gait (HP:0002317)1.72381676
131Poor coordination (HP:0002370)1.71088498
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70478313
133Abnormality of alanine metabolism (HP:0010916)1.70478313
134Hyperalaninemia (HP:0003348)1.70478313
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68433640
136Abnormal eating behavior (HP:0100738)1.67560348
137Congenital, generalized hypertrichosis (HP:0004540)1.65828232
138Delayed gross motor development (HP:0002194)1.61661823
139Bifid tongue (HP:0010297)1.61438647
140Abnormality of chromosome stability (HP:0003220)1.60827381
141Absent thumb (HP:0009777)1.60827186
142Hypoplastic pelvis (HP:0008839)1.59913333
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.59480045
144Anencephaly (HP:0002323)1.59343397
145Lissencephaly (HP:0001339)1.58708338
146Pendular nystagmus (HP:0012043)1.58330723
147Fetal akinesia sequence (HP:0001989)1.57402846
148Preaxial hand polydactyly (HP:0001177)1.57214003
149Aganglionic megacolon (HP:0002251)1.56961316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.40278395
2MAP3K123.30593282
3PNCK3.09569030
4NME12.72766520
5CDC72.72370266
6ARAF2.70434099
7STK392.66811133
8VRK22.62523715
9NTRK32.52307450
10ZAK2.46810012
11TRIM282.39721467
12EPHA42.32381176
13OXSR12.24941979
14WNK32.14936230
15MAP2K72.11450289
16STK162.03883508
17PLK22.03152555
18CDK191.95726704
19BCR1.90814252
20TNIK1.86319972
21PBK1.78627887
22TLK11.70702517
23MAP3K41.67346462
24MST41.60123936
25TTK1.59646016
26GRK51.53414581
27BMPR21.53263190
28PLK41.51250770
29MARK11.48140440
30RIPK41.45869364
31MINK11.44619128
32NUAK11.44137999
33BUB11.43588728
34MAPKAPK51.39562886
35MAPK131.36688427
36MAP3K91.36530264
37CAMK2B1.35305463
38MAP4K21.34252974
39GRK71.30782750
40PLK11.30338397
41PINK11.28510789
42FGR1.25365694
43BMPR1B1.23692693
44NEK11.22348548
45CAMK2A1.18273839
46BCKDK1.18176479
47BRAF1.17143753
48LIMK11.15307842
49FES1.13726578
50CSNK1G31.12478170
51MUSK1.10515369
52PKN11.09517423
53PRPF4B1.08361055
54CAMK2D1.07984091
55DYRK31.06515108
56NTRK11.06112060
57WNK41.05813496
58EIF2AK11.04761629
59UHMK11.04560180
60MAP2K41.00315943
61VRK10.99502923
62MYLK0.93288689
63EIF2AK30.92948612
64PDK20.91567622
65BRSK20.90954975
66IRAK20.89049720
67MAP3K130.88844148
68GRK10.86499271
69CSNK1G20.86072174
70ADRBK20.85333788
71ROCK20.85001978
72CDK50.82050057
73BRSK10.81749060
74CDK140.81536028
75EPHB20.81187473
76CAMK2G0.80267136
77PRKCG0.77916943
78ATR0.76165519
79CDK180.75940807
80NTRK20.75499193
81PTK2B0.74971773
82PRKCE0.74018661
83CDK150.71174868
84DYRK20.70747783
85INSRR0.70646905
86CHEK20.70090227
87CSNK1G10.69268476
88AURKB0.68758975
89DYRK1A0.67193281
90CDK11A0.66935448
91NEK60.66071621
92CSNK1E0.65638731
93ADRBK10.63676104
94RPS6KA40.59666497
95RAF10.59425593
96CSNK2A10.58252092
97TSSK60.56932316
98PLK30.56749868
99MKNK20.56687439
100STK38L0.56646951
101TAF10.56307948
102CSNK2A20.55385444
103ATM0.55053503
104ABL20.53421287
105PIM20.53155334
106WEE10.52900921
107GRK60.52244313
108RPS6KA50.52069890
109PAK10.51785172
110MOS0.51723361
111DAPK10.49991761
112NME20.49470945
113KSR10.48113672
114SRPK10.47817983
115CSNK1A1L0.47431443
116CCNB10.47044961
117PRKACA0.46962805
118NEK20.45905421
119CAMKK20.44088733
120ILK0.43783570
121TESK20.43525507
122CHEK10.43470102
123PRKCQ0.43342324
124OBSCN0.43099810
125PRKCI0.42263686
126PHKG10.41841883
127PHKG20.41841883
128TIE10.41808591
129IRAK40.41083885
130DAPK30.40633633
131CDK80.40277188
132PAK60.39689841
133CSNK1A10.39535826
134MKNK10.39497257
135IRAK10.39056556
136AURKA0.38521915
137PRKG10.35300859
138PAK30.34986887
139BLK0.34765517

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.49268010
2Parkinsons disease_Homo sapiens_hsa050124.49422924
3Alzheimers disease_Homo sapiens_hsa050103.64766330
4Huntingtons disease_Homo sapiens_hsa050163.21209153
5Mismatch repair_Homo sapiens_hsa034303.08577940
6Proteasome_Homo sapiens_hsa030502.97332731
7Nicotine addiction_Homo sapiens_hsa050332.93856569
8Collecting duct acid secretion_Homo sapiens_hsa049662.75713973
9Protein export_Homo sapiens_hsa030602.53375558
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51599705
11DNA replication_Homo sapiens_hsa030302.49675004
12Cardiac muscle contraction_Homo sapiens_hsa042602.33780641
13Synaptic vesicle cycle_Homo sapiens_hsa047212.33148749
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11019591
15Ribosome_Homo sapiens_hsa030102.10302719
16RNA polymerase_Homo sapiens_hsa030202.05192768
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99675806
18Vibrio cholerae infection_Homo sapiens_hsa051101.92309149
19Serotonergic synapse_Homo sapiens_hsa047261.74026908
20GABAergic synapse_Homo sapiens_hsa047271.68471351
21Morphine addiction_Homo sapiens_hsa050321.55770506
22Base excision repair_Homo sapiens_hsa034101.51480189
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51458989
24Glutamatergic synapse_Homo sapiens_hsa047241.51429232
25Amphetamine addiction_Homo sapiens_hsa050311.51290149
26RNA transport_Homo sapiens_hsa030131.50934714
27Taste transduction_Homo sapiens_hsa047421.47790423
28Long-term potentiation_Homo sapiens_hsa047201.44301454
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43191903
30Circadian entrainment_Homo sapiens_hsa047131.38484129
31Phototransduction_Homo sapiens_hsa047441.37884648
32Dopaminergic synapse_Homo sapiens_hsa047281.37029764
33Fatty acid elongation_Homo sapiens_hsa000621.33604171
34Olfactory transduction_Homo sapiens_hsa047401.30216220
35Propanoate metabolism_Homo sapiens_hsa006401.29927361
36Long-term depression_Homo sapiens_hsa047301.29232604
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28040304
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21798144
39Cell cycle_Homo sapiens_hsa041101.19503400
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16177610
41Rheumatoid arthritis_Homo sapiens_hsa053231.14994447
42One carbon pool by folate_Homo sapiens_hsa006701.13350702
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.13086426
44Cocaine addiction_Homo sapiens_hsa050301.09533748
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09438668
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06706602
47Salivary secretion_Homo sapiens_hsa049701.04157649
48Renin secretion_Homo sapiens_hsa049241.02689214
49Steroid biosynthesis_Homo sapiens_hsa001000.99573516
50Folate biosynthesis_Homo sapiens_hsa007900.96889301
51Ether lipid metabolism_Homo sapiens_hsa005650.96746630
52Calcium signaling pathway_Homo sapiens_hsa040200.95662654
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93947434
54Cholinergic synapse_Homo sapiens_hsa047250.91618032
55Basal transcription factors_Homo sapiens_hsa030220.89029724
56Glutathione metabolism_Homo sapiens_hsa004800.87368964
57Sphingolipid metabolism_Homo sapiens_hsa006000.82254063
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80384794
59Butanoate metabolism_Homo sapiens_hsa006500.76581732
60Oxytocin signaling pathway_Homo sapiens_hsa049210.76221206
61Axon guidance_Homo sapiens_hsa043600.75519054
62Gastric acid secretion_Homo sapiens_hsa049710.73738521
63Phagosome_Homo sapiens_hsa041450.72969247
64Regulation of autophagy_Homo sapiens_hsa041400.69560373
65Insulin secretion_Homo sapiens_hsa049110.68225586
66Sulfur relay system_Homo sapiens_hsa041220.67499367
67Nitrogen metabolism_Homo sapiens_hsa009100.67357901
68Purine metabolism_Homo sapiens_hsa002300.67072600
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64881193
70Pyrimidine metabolism_Homo sapiens_hsa002400.64600176
71Selenocompound metabolism_Homo sapiens_hsa004500.64549852
72Peroxisome_Homo sapiens_hsa041460.62958678
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62789249
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61688334
75Gap junction_Homo sapiens_hsa045400.61431630
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60811817
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60189446
78Oocyte meiosis_Homo sapiens_hsa041140.59474059
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57925273
80mRNA surveillance pathway_Homo sapiens_hsa030150.56369855
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.56158822
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53667861
83Metabolic pathways_Homo sapiens_hsa011000.52068083
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51639600
85Alcoholism_Homo sapiens_hsa050340.51053194
86GnRH signaling pathway_Homo sapiens_hsa049120.50351775
87Nucleotide excision repair_Homo sapiens_hsa034200.47418484
88Sulfur metabolism_Homo sapiens_hsa009200.46338398
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45626877
90Hedgehog signaling pathway_Homo sapiens_hsa043400.45611436
91beta-Alanine metabolism_Homo sapiens_hsa004100.44710205
92Melanogenesis_Homo sapiens_hsa049160.44475218
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43936269
94Carbon metabolism_Homo sapiens_hsa012000.42721664
95Spliceosome_Homo sapiens_hsa030400.42238763
96p53 signaling pathway_Homo sapiens_hsa041150.42079002
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41754874
98Arginine and proline metabolism_Homo sapiens_hsa003300.41261095
99Biosynthesis of amino acids_Homo sapiens_hsa012300.41182084
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41022261
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40257546
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40152590
103cAMP signaling pathway_Homo sapiens_hsa040240.39198081
104Arachidonic acid metabolism_Homo sapiens_hsa005900.37186887
105Homologous recombination_Homo sapiens_hsa034400.37031583
106Non-homologous end-joining_Homo sapiens_hsa034500.36631546
107Pancreatic secretion_Homo sapiens_hsa049720.35758203
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35497166
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34155631
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34064483
111Autoimmune thyroid disease_Homo sapiens_hsa053200.33840031
112Chemical carcinogenesis_Homo sapiens_hsa052040.30013141
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29727810
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29279537
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29047473
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28481783
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28087748
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.27164210
119Ras signaling pathway_Homo sapiens_hsa040140.26951989
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.26874937
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26765699
122Linoleic acid metabolism_Homo sapiens_hsa005910.26292039
123Wnt signaling pathway_Homo sapiens_hsa043100.26223015
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25764369
125RNA degradation_Homo sapiens_hsa030180.25577026
126Fatty acid metabolism_Homo sapiens_hsa012120.21607754
127Circadian rhythm_Homo sapiens_hsa047100.20940700
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.20871819
129Pyruvate metabolism_Homo sapiens_hsa006200.20796933
130Estrogen signaling pathway_Homo sapiens_hsa049150.19574845
131Vitamin B6 metabolism_Homo sapiens_hsa007500.17837262
132Tyrosine metabolism_Homo sapiens_hsa003500.17648062
133African trypanosomiasis_Homo sapiens_hsa051430.16673044
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15867432
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15443782
136Type I diabetes mellitus_Homo sapiens_hsa049400.14979144
137Renal cell carcinoma_Homo sapiens_hsa052110.14409721
138ErbB signaling pathway_Homo sapiens_hsa040120.12981968
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12958711
140Fanconi anemia pathway_Homo sapiens_hsa034600.12270579
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12197134
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11703258

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