

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.60480842 |
| 2 | negative regulation of T cell mediated immunity (GO:0002710) | 4.37217706 |
| 3 | detection of molecule of bacterial origin (GO:0032490) | 4.22626079 |
| 4 | negative regulation of interleukin-12 production (GO:0032695) | 4.21190615 |
| 5 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.12967073 |
| 6 | positive regulation of interferon-alpha production (GO:0032727) | 4.11447642 |
| 7 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.09907198 |
| 8 | cellular extravasation (GO:0045123) | 4.04447135 |
| 9 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.95764017 |
| 10 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.95764017 |
| 11 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.95764017 |
| 12 | modulation by symbiont of host immune response (GO:0052553) | 3.95764017 |
| 13 | positive regulation by symbiont of host defense response (GO:0052509) | 3.95764017 |
| 14 | modulation by symbiont of host defense response (GO:0052031) | 3.95764017 |
| 15 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.95133146 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.95133146 |
| 17 | regulation of interferon-alpha production (GO:0032647) | 3.89484945 |
| 18 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.88680785 |
| 19 | detection of other organism (GO:0098543) | 3.88618634 |
| 20 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.80988265 |
| 21 | detection of external biotic stimulus (GO:0098581) | 3.68810573 |
| 22 | positive regulation of type 2 immune response (GO:0002830) | 3.61889549 |
| 23 | detection of bacterium (GO:0016045) | 3.58529763 |
| 24 | response to interleukin-15 (GO:0070672) | 3.56667475 |
| 25 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.55716730 |
| 26 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.36526798 |
| 27 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.36273181 |
| 28 | response to type I interferon (GO:0034340) | 3.33469096 |
| 29 | interferon-gamma production (GO:0032609) | 3.30091273 |
| 30 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.29203889 |
| 31 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.27922033 |
| 32 | natural killer cell mediated immunity (GO:0002228) | 3.27922033 |
| 33 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.27903589 |
| 34 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.27790876 |
| 35 | type I interferon signaling pathway (GO:0060337) | 3.27558180 |
| 36 | cellular response to type I interferon (GO:0071357) | 3.27558180 |
| 37 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.26986980 |
| 38 | germinal center formation (GO:0002467) | 3.22700328 |
| 39 | detection of biotic stimulus (GO:0009595) | 3.21745908 |
| 40 | neutrophil activation involved in immune response (GO:0002283) | 3.20174710 |
| 41 | microglial cell activation (GO:0001774) | 3.20046373 |
| 42 | regulation of gamma-delta T cell activation (GO:0046643) | 3.19578820 |
| 43 | macrophage activation (GO:0042116) | 3.14880431 |
| 44 | macrophage activation involved in immune response (GO:0002281) | 3.13843605 |
| 45 | positive regulation of histone deacetylation (GO:0031065) | 3.13574215 |
| 46 | immunoglobulin mediated immune response (GO:0016064) | 3.11855494 |
| 47 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.11196166 |
| 48 | leukocyte aggregation (GO:0070486) | 3.10298891 |
| 49 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.09534995 |
| 50 | regulation of cholesterol storage (GO:0010885) | 3.03097343 |
| 51 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.99405499 |
| 52 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.98729717 |
| 53 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.98729717 |
| 54 | positive regulation of interferon-beta production (GO:0032728) | 2.98597114 |
| 55 | cellular response to interleukin-15 (GO:0071350) | 2.96748520 |
| 56 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.94541274 |
| 57 | B cell receptor signaling pathway (GO:0050853) | 2.93584944 |
| 58 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.92353864 |
| 59 | response to interferon-alpha (GO:0035455) | 2.91194052 |
| 60 | negative regulation of adaptive immune response (GO:0002820) | 2.90363491 |
| 61 | cellular response to ethanol (GO:0071361) | 2.89282295 |
| 62 | negative regulation of production of molecular mediator of immune response (GO:0002701) | 2.88581652 |
| 63 | urea cycle (GO:0000050) | 2.87698699 |
| 64 | urea metabolic process (GO:0019627) | 2.87698699 |
| 65 | granulocyte activation (GO:0036230) | 2.87478122 |
| 66 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.86810896 |
| 67 | protein carboxylation (GO:0018214) | 2.86810896 |
| 68 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.84820579 |
| 69 | lymphocyte chemotaxis (GO:0048247) | 2.84099537 |
| 70 | cellular response to virus (GO:0098586) | 2.83343403 |
| 71 | low-density lipoprotein particle clearance (GO:0034383) | 2.82602157 |
| 72 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.82155962 |
| 73 | natural killer cell differentiation (GO:0001779) | 2.80868660 |
| 74 | neutrophil mediated immunity (GO:0002446) | 2.80428202 |
| 75 | complement activation, alternative pathway (GO:0006957) | 2.80411147 |
| 76 | positive regulation of B cell differentiation (GO:0045579) | 2.80372764 |
| 77 | leukocyte migration involved in inflammatory response (GO:0002523) | 2.79096230 |
| 78 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.78782406 |
| 79 | regulation of type 2 immune response (GO:0002828) | 2.77952913 |
| 80 | histone H3-K36 demethylation (GO:0070544) | 2.77721429 |
| 81 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.77098104 |
| 82 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.76539141 |
| 83 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.76128883 |
| 84 | response to peptidoglycan (GO:0032494) | 2.73816251 |
| 85 | cellular response to interferon-alpha (GO:0035457) | 2.73795653 |
| 86 | T cell migration (GO:0072678) | 2.72965946 |
| 87 | regulation of T cell tolerance induction (GO:0002664) | 2.72950707 |
| 88 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.72806213 |
| 89 | response to protozoan (GO:0001562) | 2.72440042 |
| 90 | regulation of mast cell degranulation (GO:0043304) | 2.72311723 |
| 91 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.68730825 |
| 92 | positive regulation of B cell mediated immunity (GO:0002714) | 2.68730825 |
| 93 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.68619808 |
| 94 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.65525530 |
| 95 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.63160696 |
| 96 | response to host immune response (GO:0052572) | 2.63160696 |
| 97 | regulation of mast cell activation (GO:0033003) | 2.62625614 |
| 98 | regulation of tolerance induction (GO:0002643) | 2.62239500 |
| 99 | neutrophil chemotaxis (GO:0030593) | 2.62188531 |
| 100 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.60364010 |
| 101 | respiratory burst (GO:0045730) | 2.60097804 |
| 102 | neutrophil activation (GO:0042119) | 2.58189376 |
| 103 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.57939249 |
| 104 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.57728614 |
| 105 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.57209678 |
| 106 | growth hormone receptor signaling pathway (GO:0060396) | 2.56855777 |
| 107 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.56493399 |
| 108 | nitrogen cycle metabolic process (GO:0071941) | 2.56246308 |
| 109 | regulation of RIG-I signaling pathway (GO:0039535) | 2.55200516 |
| 110 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.54887936 |
| 111 | positive regulation of humoral immune response (GO:0002922) | 2.54887317 |
| 112 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.52881354 |
| 113 | I-kappaB phosphorylation (GO:0007252) | 2.50618996 |
| 114 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.48435323 |
| 115 | plasma lipoprotein particle clearance (GO:0034381) | 2.47236177 |
| 116 | negative regulation of cell killing (GO:0031342) | 2.46678954 |
| 117 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.46678954 |
| 118 | response to host defenses (GO:0052200) | 2.46205547 |
| 119 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.46205547 |
| 120 | response to host (GO:0075136) | 2.46205547 |
| 121 | regulation of hypersensitivity (GO:0002883) | 2.46101248 |
| 122 | response to muramyl dipeptide (GO:0032495) | 2.44444958 |
| 123 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.44254622 |
| 124 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.44079990 |
| 125 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.43894129 |
| 126 | negative regulation of lipid storage (GO:0010888) | 2.43858193 |
| 127 | regulation of interferon-beta production (GO:0032648) | 2.43674751 |
| 128 | phospholipid homeostasis (GO:0055091) | 2.41349849 |
| 129 | cellular response to exogenous dsRNA (GO:0071360) | 2.40721252 |
| 130 | positive thymic T cell selection (GO:0045059) | 2.39807695 |
| 131 | B cell mediated immunity (GO:0019724) | 2.36816491 |
| 132 | phospholipid efflux (GO:0033700) | 2.36265807 |
| 133 | myeloid cell activation involved in immune response (GO:0002275) | 2.35676207 |
| 134 | regulation of cholesterol homeostasis (GO:2000188) | 2.35621148 |
| 135 | myeloid dendritic cell differentiation (GO:0043011) | 2.35345264 |
| 136 | alpha-linolenic acid metabolic process (GO:0036109) | 2.33961626 |
| 137 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 2.33324979 |
| 138 | regulation of B cell differentiation (GO:0045577) | 2.33289860 |
| 139 | L-alpha-amino acid transmembrane transport (GO:1902475) | 2.32686769 |
| 140 | defense response to protozoan (GO:0042832) | 2.32116091 |
| 141 | negative regulation of viral genome replication (GO:0045071) | 2.31842531 |
| 142 | JAK-STAT cascade (GO:0007259) | 2.31675085 |
| 143 | positive regulation of lipid storage (GO:0010884) | 2.30043495 |
| 144 | kynurenine metabolic process (GO:0070189) | 2.27577398 |
| 145 | positive regulation of response to biotic stimulus (GO:0002833) | 2.27457141 |
| 146 | cytokine secretion (GO:0050663) | 2.26634443 |
| 147 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.26123654 |
| 148 | regulation of protein activation cascade (GO:2000257) | 2.25966973 |
| 149 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.25932690 |
| 150 | indolalkylamine catabolic process (GO:0046218) | 2.25726151 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.54388791 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.33037756 |
| 3 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.91987499 |
| 4 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.60151535 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.56783033 |
| 6 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.22286868 |
| 7 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.21865918 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.16050142 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.15311379 |
| 10 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.07831574 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.05626469 |
| 12 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.00400364 |
| 13 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.98001697 |
| 14 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.91912791 |
| 15 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.84787047 |
| 16 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.77527851 |
| 17 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.74859298 |
| 18 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.67247409 |
| 19 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.64493763 |
| 20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.60207618 |
| 21 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 2.38023682 |
| 22 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.35216131 |
| 23 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.27299345 |
| 24 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.19370968 |
| 25 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.02928652 |
| 26 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.99140883 |
| 27 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.97746876 |
| 28 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.93828662 |
| 29 | * MYC_22102868_ChIP-Seq_BL_Human | 1.93258939 |
| 30 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.87470630 |
| 31 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.84476774 |
| 32 | MYB_26560356_Chip-Seq_TH2_Human | 1.82833507 |
| 33 | MYB_26560356_Chip-Seq_TH1_Human | 1.81098189 |
| 34 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.80840977 |
| 35 | * MAF_26560356_Chip-Seq_TH1_Human | 1.72461159 |
| 36 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.67769447 |
| 37 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.58665078 |
| 38 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.55623247 |
| 39 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.52211945 |
| 40 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.50577137 |
| 41 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.49483896 |
| 42 | UTX_26944678_Chip-Seq_JUKART_Human | 1.46374513 |
| 43 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.41442104 |
| 44 | SPI1_23127762_ChIP-Seq_K562_Human | 1.40342678 |
| 45 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.39455030 |
| 46 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.38908339 |
| 47 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.37447408 |
| 48 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.37382198 |
| 49 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.36321959 |
| 50 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.36152179 |
| 51 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.31711302 |
| 52 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.30426789 |
| 53 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.28335683 |
| 54 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.27869325 |
| 55 | GATA1_22025678_ChIP-Seq_K562_Human | 1.26951753 |
| 56 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.21552216 |
| 57 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20696196 |
| 58 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.19796370 |
| 59 | * FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.18882754 |
| 60 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.17547224 |
| 61 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.16626260 |
| 62 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.14568290 |
| 63 | GATA3_26560356_Chip-Seq_TH2_Human | 1.12523795 |
| 64 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.09091803 |
| 65 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.08305748 |
| 66 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.08205410 |
| 67 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.06549145 |
| 68 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.05407721 |
| 69 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.03106933 |
| 70 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02480723 |
| 71 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.01176720 |
| 72 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.00932000 |
| 73 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.00230978 |
| 74 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.00002221 |
| 75 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.99801662 |
| 76 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.99666332 |
| 77 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.99227519 |
| 78 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.97221501 |
| 79 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.96942603 |
| 80 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96843322 |
| 81 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93351253 |
| 82 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.92735545 |
| 83 | * GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.92643156 |
| 84 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.90923032 |
| 85 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.88057666 |
| 86 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.86756980 |
| 87 | * MAF_26560356_Chip-Seq_TH2_Human | 0.86012849 |
| 88 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.85093999 |
| 89 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.84694424 |
| 90 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.84579240 |
| 91 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.83847128 |
| 92 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.83611894 |
| 93 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83263331 |
| 94 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81844452 |
| 95 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81423845 |
| 96 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.80966196 |
| 97 | GATA2_19941826_ChIP-Seq_K562_Human | 0.80676464 |
| 98 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80406382 |
| 99 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.80384733 |
| 100 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.79480966 |
| 101 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.78775361 |
| 102 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.77735364 |
| 103 | * LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.77621806 |
| 104 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.77525246 |
| 105 | GATA3_26560356_Chip-Seq_TH1_Human | 0.77061376 |
| 106 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.76653777 |
| 107 | GATA1_19941826_ChIP-Seq_K562_Human | 0.75766789 |
| 108 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.75063881 |
| 109 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74891392 |
| 110 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.74804419 |
| 111 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74687528 |
| 112 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.74284303 |
| 113 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.74212891 |
| 114 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.74100077 |
| 115 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.73644597 |
| 116 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.70616950 |
| 117 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.69669767 |
| 118 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.68267166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.20800437 |
| 2 | MP0003436_decreased_susceptibility_to | 3.13477637 |
| 3 | MP0003303_peritoneal_inflammation | 2.84672608 |
| 4 | MP0002139_abnormal_hepatobiliary_system | 2.79363709 |
| 5 | MP0003300_gastrointestinal_ulcer | 2.50217875 |
| 6 | MP0005451_abnormal_body_composition | 2.48590176 |
| 7 | MP0005360_urolithiasis | 2.39750388 |
| 8 | MP0000685_abnormal_immune_system | 2.38901122 |
| 9 | MP0005387_immune_system_phenotype | 2.37934042 |
| 10 | MP0001790_abnormal_immune_system | 2.37934042 |
| 11 | MP0006082_CNS_inflammation | 2.37473778 |
| 12 | MP0009785_altered_susceptibility_to | 2.36182844 |
| 13 | MP0005000_abnormal_immune_tolerance | 2.28292826 |
| 14 | MP0001800_abnormal_humoral_immune | 2.22620109 |
| 15 | MP0005365_abnormal_bile_salt | 2.21601572 |
| 16 | MP0002419_abnormal_innate_immunity | 2.07399730 |
| 17 | MP0005025_abnormal_response_to | 2.07355123 |
| 18 | MP0004947_skin_inflammation | 2.06262855 |
| 19 | MP0002452_abnormal_antigen_presenting | 2.00587872 |
| 20 | MP0002148_abnormal_hypersensitivity_rea | 1.98225595 |
| 21 | MP0002723_abnormal_immune_serum | 1.97546959 |
| 22 | MP0005671_abnormal_response_to | 1.96290852 |
| 23 | MP0003705_abnormal_hypodermis_morpholog | 1.95686991 |
| 24 | MP0003252_abnormal_bile_duct | 1.95431426 |
| 25 | MP0009840_abnormal_foam_cell | 1.94741250 |
| 26 | MP0005085_abnormal_gallbladder_physiolo | 1.90288065 |
| 27 | MP0005076_abnormal_cell_differentiation | 1.78382624 |
| 28 | MP0010352_gastrointestinal_tract_polyps | 1.78203115 |
| 29 | MP0003724_increased_susceptibility_to | 1.76810842 |
| 30 | MP0004510_myositis | 1.76730389 |
| 31 | MP0005058_abnormal_lysosome_morphology | 1.72925369 |
| 32 | MP0002877_abnormal_melanocyte_morpholog | 1.72146240 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.71506430 |
| 34 | MP0003191_abnormal_cellular_cholesterol | 1.71088949 |
| 35 | MP0005464_abnormal_platelet_physiology | 1.67763378 |
| 36 | MP0001819_abnormal_immune_cell | 1.67195476 |
| 37 | MP0002420_abnormal_adaptive_immunity | 1.65405955 |
| 38 | MP0003656_abnormal_erythrocyte_physiolo | 1.63955407 |
| 39 | MP0001845_abnormal_inflammatory_respons | 1.56735984 |
| 40 | MP0002138_abnormal_hepatobiliary_system | 1.56278216 |
| 41 | MP0000609_abnormal_liver_physiology | 1.54665375 |
| 42 | MP0002006_tumorigenesis | 1.53495177 |
| 43 | MP0004381_abnormal_hair_follicle | 1.52350948 |
| 44 | MP0009764_decreased_sensitivity_to | 1.50988043 |
| 45 | MP0001533_abnormal_skeleton_physiology | 1.47081087 |
| 46 | MP0010329_abnormal_lipoprotein_level | 1.46921709 |
| 47 | MP0008469_abnormal_protein_level | 1.45389534 |
| 48 | MP0009278_abnormal_bone_marrow | 1.44696328 |
| 49 | MP0002405_respiratory_system_inflammati | 1.44636330 |
| 50 | MP0010155_abnormal_intestine_physiology | 1.43867488 |
| 51 | MP0002398_abnormal_bone_marrow | 1.43367224 |
| 52 | MP0001853_heart_inflammation | 1.42670628 |
| 53 | MP0000569_abnormal_digit_pigmentation | 1.42585029 |
| 54 | MP0003172_abnormal_lysosome_physiology | 1.42089063 |
| 55 | MP0000716_abnormal_immune_system | 1.37751184 |
| 56 | MP0010307_abnormal_tumor_latency | 1.37751064 |
| 57 | MP0008875_abnormal_xenobiotic_pharmacok | 1.36906824 |
| 58 | MP0003763_abnormal_thymus_physiology | 1.33367143 |
| 59 | MP0005397_hematopoietic_system_phenotyp | 1.28358611 |
| 60 | MP0001545_abnormal_hematopoietic_system | 1.28358611 |
| 61 | MP0005310_abnormal_salivary_gland | 1.27198318 |
| 62 | MP0005410_abnormal_fertilization | 1.21660830 |
| 63 | MP0002254_reproductive_system_inflammat | 1.20977544 |
| 64 | MP0003828_pulmonary_edema | 1.19683536 |
| 65 | MP0003045_fibrosis | 1.18806528 |
| 66 | MP0003448_altered_tumor_morphology | 1.18511235 |
| 67 | MP0008260_abnormal_autophagy | 1.18092223 |
| 68 | MP0003690_abnormal_glial_cell | 1.17486882 |
| 69 | MP0004883_abnormal_blood_vessel | 1.17343101 |
| 70 | MP0000689_abnormal_spleen_morphology | 1.17038470 |
| 71 | MP0010234_abnormal_vibrissa_follicle | 1.13804082 |
| 72 | MP0003453_abnormal_keratinocyte_physiol | 1.13028578 |
| 73 | MP0004808_abnormal_hematopoietic_stem | 1.11874102 |
| 74 | MP0003866_abnormal_defecation | 1.11366777 |
| 75 | MP0008057_abnormal_DNA_replication | 1.11010448 |
| 76 | MP0002429_abnormal_blood_cell | 1.10696478 |
| 77 | MP0000015_abnormal_ear_pigmentation | 1.10620160 |
| 78 | MP0009763_increased_sensitivity_to | 1.10326989 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 1.09994280 |
| 80 | MP0003566_abnormal_cell_adhesion | 1.09934650 |
| 81 | MP0002722_abnormal_immune_system | 1.09790022 |
| 82 | MP0002998_abnormal_bone_remodeling | 1.07219460 |
| 83 | MP0005083_abnormal_biliary_tract | 1.07116674 |
| 84 | MP0005164_abnormal_response_to | 1.07086090 |
| 85 | MP0005670_abnormal_white_adipose | 1.06796354 |
| 86 | MP0003195_calcinosis | 1.04851661 |
| 87 | MP0002132_abnormal_respiratory_system | 1.04465384 |
| 88 | MP0000465_gastrointestinal_hemorrhage | 1.03784515 |
| 89 | MP0009333_abnormal_splenocyte_physiolog | 1.01955806 |
| 90 | MP0003075_altered_response_to | 1.00166980 |
| 91 | MP0000604_amyloidosis | 0.98635382 |
| 92 | MP0005319_abnormal_enzyme/_coenzyme | 0.98150437 |
| 93 | MP0004185_abnormal_adipocyte_glucose | 0.97807703 |
| 94 | MP0002928_abnormal_bile_duct | 0.97315797 |
| 95 | MP0000858_altered_metastatic_potential | 0.96836017 |
| 96 | MP0002118_abnormal_lipid_homeostasis | 0.94692752 |
| 97 | MP0000598_abnormal_liver_morphology | 0.94124433 |
| 98 | MP0008004_abnormal_stomach_pH | 0.93361819 |
| 99 | MP0002693_abnormal_pancreas_physiology | 0.92681374 |
| 100 | MP0005023_abnormal_wound_healing | 0.91770338 |
| 101 | MP0003868_abnormal_feces_composition | 0.86923809 |
| 102 | MP0008961_abnormal_basal_metabolism | 0.83919557 |
| 103 | MP0000703_abnormal_thymus_morphology | 0.82306190 |
| 104 | MP0000343_altered_response_to | 0.81992546 |
| 105 | MP0005166_decreased_susceptibility_to | 0.81665296 |
| 106 | MP0001851_eye_inflammation | 0.81267147 |
| 107 | MP0000371_diluted_coat_color | 0.79206206 |
| 108 | MP0002396_abnormal_hematopoietic_system | 0.78988420 |
| 109 | MP0002332_abnormal_exercise_endurance | 0.78150988 |
| 110 | MP0003646_muscle_fatigue | 0.77861919 |
| 111 | MP0009643_abnormal_urine_homeostasis | 0.77667329 |
| 112 | MP0001666_abnormal_nutrient_absorption | 0.76534713 |
| 113 | MP0003221_abnormal_cardiomyocyte_apopto | 0.75502461 |
| 114 | MP0003091_abnormal_cell_migration | 0.74775884 |
| 115 | MP0001915_intracranial_hemorrhage | 0.74581239 |
| 116 | MP0000249_abnormal_blood_vessel | 0.73447985 |
| 117 | MP0005647_abnormal_sex_gland | 0.73219429 |
| 118 | MP0003183_abnormal_peptide_metabolism | 0.72488955 |
| 119 | MP0001873_stomach_inflammation | 0.72247992 |
| 120 | MP0009115_abnormal_fat_cell | 0.70802165 |
| 121 | MP0002136_abnormal_kidney_physiology | 0.70785455 |
| 122 | MP0005409_darkened_coat_color | 0.68252592 |
| 123 | MP0004130_abnormal_muscle_cell | 0.66682576 |
| 124 | MP0005167_abnormal_blood-brain_barrier | 0.63901106 |
| 125 | MP0005666_abnormal_adipose_tissue | 0.61694227 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 4.88554030 |
| 2 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.45538749 |
| 3 | Keratoconjunctivitis sicca (HP:0001097) | 4.35576169 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 4.17335846 |
| 5 | Keratoconjunctivitis (HP:0001096) | 4.02866903 |
| 6 | Recurrent abscess formation (HP:0002722) | 3.89929266 |
| 7 | Autoimmune thrombocytopenia (HP:0001973) | 3.78409316 |
| 8 | Myocardial infarction (HP:0001658) | 3.74619470 |
| 9 | Nasal polyposis (HP:0100582) | 3.41963586 |
| 10 | Deep venous thrombosis (HP:0002625) | 3.41739085 |
| 11 | Encephalitis (HP:0002383) | 3.30797196 |
| 12 | Recurrent fungal infections (HP:0002841) | 3.28416001 |
| 13 | Recurrent viral infections (HP:0004429) | 3.26130302 |
| 14 | Hemoptysis (HP:0002105) | 3.20007714 |
| 15 | Systemic lupus erythematosus (HP:0002725) | 3.19985384 |
| 16 | Joint hemorrhage (HP:0005261) | 3.08530219 |
| 17 | Complement deficiency (HP:0004431) | 2.97448813 |
| 18 | Abnormality of the common coagulation pathway (HP:0010990) | 2.95304212 |
| 19 | Abnormality of the nasal mucosa (HP:0000433) | 2.92807037 |
| 20 | Hypochromic microcytic anemia (HP:0004840) | 2.87756805 |
| 21 | Gingival bleeding (HP:0000225) | 2.85229016 |
| 22 | Recurrent skin infections (HP:0001581) | 2.83506759 |
| 23 | Mediastinal lymphadenopathy (HP:0100721) | 2.83271095 |
| 24 | Xanthomatosis (HP:0000991) | 2.82559943 |
| 25 | Gangrene (HP:0100758) | 2.82512907 |
| 26 | Chronic obstructive pulmonary disease (HP:0006510) | 2.73826944 |
| 27 | Obstructive lung disease (HP:0006536) | 2.73826944 |
| 28 | Prolonged bleeding time (HP:0003010) | 2.73359423 |
| 29 | Vasculitis (HP:0002633) | 2.69824205 |
| 30 | Cellulitis (HP:0100658) | 2.67345742 |
| 31 | Hypochromic anemia (HP:0001931) | 2.66902148 |
| 32 | Anorexia (HP:0002039) | 2.66245152 |
| 33 | Periodontitis (HP:0000704) | 2.64850606 |
| 34 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.61062808 |
| 35 | Interstitial pulmonary disease (HP:0006530) | 2.60549380 |
| 36 | Recurrent bronchitis (HP:0002837) | 2.59992333 |
| 37 | Abnormality of macrophages (HP:0004311) | 2.59948510 |
| 38 | Slow saccadic eye movements (HP:0000514) | 2.58705486 |
| 39 | Gingivitis (HP:0000230) | 2.58127168 |
| 40 | Hypercholesterolemia (HP:0003124) | 2.57630050 |
| 41 | Abnormality of complement system (HP:0005339) | 2.56809999 |
| 42 | Colitis (HP:0002583) | 2.55959958 |
| 43 | Prolonged partial thromboplastin time (HP:0003645) | 2.55641343 |
| 44 | Intrahepatic cholestasis (HP:0001406) | 2.55450722 |
| 45 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.53075571 |
| 46 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.53075571 |
| 47 | Abnormality of glycolipid metabolism (HP:0010969) | 2.53075571 |
| 48 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.47976937 |
| 49 | Chest pain (HP:0100749) | 2.47291721 |
| 50 | Hemorrhage of the eye (HP:0011885) | 2.42965728 |
| 51 | Upper motor neuron abnormality (HP:0002127) | 2.41140374 |
| 52 | Arterial thrombosis (HP:0004420) | 2.40958273 |
| 53 | Hematochezia (HP:0002573) | 2.39546632 |
| 54 | Abnormality of the pleura (HP:0002103) | 2.39518132 |
| 55 | Myositis (HP:0100614) | 2.38020238 |
| 56 | Disinhibition (HP:0000734) | 2.35442035 |
| 57 | Loss of speech (HP:0002371) | 2.34624159 |
| 58 | Abnormality of the endocardium (HP:0004306) | 2.34106176 |
| 59 | Mucopolysacchariduria (HP:0008155) | 2.33700860 |
| 60 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.33700860 |
| 61 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.33390906 |
| 62 | Abnormality of the fingertips (HP:0001211) | 2.31881664 |
| 63 | Tetraparesis (HP:0002273) | 2.31323543 |
| 64 | Esophageal varix (HP:0002040) | 2.31058964 |
| 65 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.30913350 |
| 66 | Recurrent cutaneous fungal infections (HP:0011370) | 2.30913350 |
| 67 | Abnormality of T cell number (HP:0011839) | 2.30594495 |
| 68 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.29256189 |
| 69 | Orchitis (HP:0100796) | 2.28081472 |
| 70 | Mitral stenosis (HP:0001718) | 2.26981294 |
| 71 | T lymphocytopenia (HP:0005403) | 2.26393611 |
| 72 | Keratitis (HP:0000491) | 2.25554317 |
| 73 | Glomerulonephritis (HP:0000099) | 2.25463980 |
| 74 | Polyneuropathy (HP:0001271) | 2.25401335 |
| 75 | Epidermoid cyst (HP:0200040) | 2.24430777 |
| 76 | Vacuolated lymphocytes (HP:0001922) | 2.23246635 |
| 77 | Menorrhagia (HP:0000132) | 2.22910200 |
| 78 | Gastrointestinal infarctions (HP:0005244) | 2.22133433 |
| 79 | Inflammation of the large intestine (HP:0002037) | 2.22001088 |
| 80 | Urticaria (HP:0001025) | 2.21435794 |
| 81 | Increased cerebral lipofuscin (HP:0011813) | 2.21076282 |
| 82 | Thrombophlebitis (HP:0004418) | 2.19347891 |
| 83 | Autoimmune hemolytic anemia (HP:0001890) | 2.18443581 |
| 84 | Stomatitis (HP:0010280) | 2.18013325 |
| 85 | Leukocytosis (HP:0001974) | 2.17501195 |
| 86 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.17151831 |
| 87 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.17151831 |
| 88 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.17151831 |
| 89 | Episodic fever (HP:0001954) | 2.16275446 |
| 90 | Osteomyelitis (HP:0002754) | 2.14023561 |
| 91 | Pustule (HP:0200039) | 2.13916700 |
| 92 | Dysostosis multiplex (HP:0000943) | 2.12036762 |
| 93 | Bronchitis (HP:0012387) | 2.09496973 |
| 94 | Gastrointestinal inflammation (HP:0004386) | 2.08307985 |
| 95 | Nephritis (HP:0000123) | 2.07865585 |
| 96 | Pulmonary infiltrates (HP:0002113) | 2.07359298 |
| 97 | Purpura (HP:0000979) | 2.06624016 |
| 98 | Spontaneous hematomas (HP:0007420) | 2.05989511 |
| 99 | Panhypogammaglobulinemia (HP:0003139) | 2.05254429 |
| 100 | Glomerulopathy (HP:0100820) | 2.04282454 |
| 101 | Meningitis (HP:0001287) | 2.03460973 |
| 102 | Subacute progressive viral hepatitis (HP:0006572) | 2.03359992 |
| 103 | Axonal loss (HP:0003447) | 2.02532932 |
| 104 | Abnormality of T cells (HP:0002843) | 2.02068258 |
| 105 | Basal ganglia calcification (HP:0002135) | 2.01429312 |
| 106 | Microcytic anemia (HP:0001935) | 2.00465871 |
| 107 | Amyloidosis (HP:0011034) | 2.00007410 |
| 108 | Acne (HP:0001061) | 1.98285797 |
| 109 | Vertigo (HP:0002321) | 1.96529261 |
| 110 | Viral hepatitis (HP:0006562) | 1.96152157 |
| 111 | Epistaxis (HP:0000421) | 1.96037117 |
| 112 | Abnormality of T cell physiology (HP:0011840) | 1.94400417 |
| 113 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 1.94111709 |
| 114 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.93931347 |
| 115 | Joint swelling (HP:0001386) | 1.93123061 |
| 116 | Chronic otitis media (HP:0000389) | 1.91268999 |
| 117 | Increased IgM level (HP:0003496) | 1.90717401 |
| 118 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.90142585 |
| 119 | Osteolytic defects of the hand bones (HP:0009699) | 1.90142585 |
| 120 | Papillary thyroid carcinoma (HP:0002895) | 1.90006562 |
| 121 | Hypoalphalipoproteinemia (HP:0003233) | 1.88961505 |
| 122 | Increased serum ferritin (HP:0003281) | 1.87089834 |
| 123 | Recurrent sinusitis (HP:0011108) | 1.86899187 |
| 124 | Hyperlipoproteinemia (HP:0010980) | 1.85351027 |
| 125 | Increased IgE level (HP:0003212) | 1.84862509 |
| 126 | Abnormality of the peritoneum (HP:0002585) | 1.83832196 |
| 127 | Hypergammaglobulinemia (HP:0010702) | 1.83572365 |
| 128 | Retrobulbar optic neuritis (HP:0100654) | 1.83178269 |
| 129 | Optic neuritis (HP:0100653) | 1.83178269 |
| 130 | Hypoglycemic coma (HP:0001325) | 1.82781171 |
| 131 | Increased CSF protein (HP:0002922) | 1.81696335 |
| 132 | Pulmonary embolism (HP:0002204) | 1.81620782 |
| 133 | Abnormality of the intrinsic pathway (HP:0010989) | 1.80585241 |
| 134 | Abnormal platelet volume (HP:0011876) | 1.79477998 |
| 135 | Abnormality of the pericardium (HP:0001697) | 1.79346031 |
| 136 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.78161896 |
| 137 | Cerebral aneurysm (HP:0004944) | 1.77793102 |
| 138 | Hypobetalipoproteinemia (HP:0003563) | 1.75773576 |
| 139 | Conjunctival telangiectasia (HP:0000524) | 1.75750053 |
| 140 | Abnormality of iron homeostasis (HP:0011031) | 1.75032058 |
| 141 | Chronic diarrhea (HP:0002028) | 1.73869374 |
| 142 | Peritonitis (HP:0002586) | 1.72283888 |
| 143 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.72268604 |
| 144 | Memory impairment (HP:0002354) | 1.71735755 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 3.46284823 |
| 2 | TYK2 | 3.06718532 |
| 3 | MAP3K14 | 2.76230622 |
| 4 | MAP4K1 | 2.67859755 |
| 5 | CDK12 | 2.65655915 |
| 6 | FGFR4 | 2.39481577 |
| 7 | TAOK3 | 2.36954481 |
| 8 | MAP3K10 | 2.33882125 |
| 9 | JAK3 | 2.30790725 |
| 10 | TBK1 | 2.24508402 |
| 11 | PRPF4B | 2.23243759 |
| 12 | TRIB3 | 2.20112743 |
| 13 | JAK1 | 2.15454807 |
| 14 | PKN2 | 2.02373588 |
| 15 | MAP3K13 | 1.91084977 |
| 16 | FGFR3 | 1.81934110 |
| 17 | RIPK4 | 1.81680713 |
| 18 | SIK1 | 1.79589604 |
| 19 | IRAK3 | 1.76388632 |
| 20 | IKBKE | 1.76374565 |
| 21 | STK10 | 1.68842473 |
| 22 | FGR | 1.68645553 |
| 23 | FES | 1.62652409 |
| 24 | EEF2K | 1.53972877 |
| 25 | BLK | 1.50879225 |
| 26 | IRAK4 | 1.44796959 |
| 27 | TNK2 | 1.43128187 |
| 28 | CAMK1D | 1.42968827 |
| 29 | PBK | 1.42666604 |
| 30 | IKBKB | 1.35628336 |
| 31 | EPHB1 | 1.32973011 |
| 32 | RPS6KA4 | 1.31914412 |
| 33 | TGFBR2 | 1.31170542 |
| 34 | PTK6 | 1.31001063 |
| 35 | ZAP70 | 1.29458625 |
| 36 | CSK | 1.29098237 |
| 37 | CHUK | 1.28743373 |
| 38 | RIPK1 | 1.28478045 |
| 39 | CAMK1G | 1.27637742 |
| 40 | JAK2 | 1.26021152 |
| 41 | MST1R | 1.25862264 |
| 42 | STK3 | 1.23656762 |
| 43 | HCK | 1.19903528 |
| 44 | MATK | 1.17786696 |
| 45 | EPHA3 | 1.15864125 |
| 46 | YES1 | 1.14576491 |
| 47 | STK4 | 1.10108073 |
| 48 | CDK6 | 1.06929713 |
| 49 | LATS1 | 1.06482611 |
| 50 | SIK2 | 1.06205432 |
| 51 | IRAK1 | 1.06197056 |
| 52 | SGK2 | 1.06063080 |
| 53 | TXK | 1.05212611 |
| 54 | PIK3CG | 1.03812776 |
| 55 | MAP3K2 | 1.02371369 |
| 56 | MARK3 | 1.00026436 |
| 57 | KSR2 | 0.99827556 |
| 58 | BRD4 | 0.98001937 |
| 59 | SYK | 0.97781609 |
| 60 | GRK6 | 0.96506480 |
| 61 | ITK | 0.95060877 |
| 62 | MARK2 | 0.93890491 |
| 63 | BMX | 0.93413679 |
| 64 | BTK | 0.93328225 |
| 65 | CSF1R | 0.91153796 |
| 66 | KIT | 0.90554191 |
| 67 | STK24 | 0.90512299 |
| 68 | WNK1 | 0.89922416 |
| 69 | CDC42BPA | 0.89842987 |
| 70 | PIM1 | 0.88932821 |
| 71 | INSRR | 0.82987308 |
| 72 | TAOK2 | 0.81320222 |
| 73 | NLK | 0.81253736 |
| 74 | HIPK2 | 0.81085403 |
| 75 | LCK | 0.79526544 |
| 76 | SCYL2 | 0.78636179 |
| 77 | MAP3K3 | 0.77800074 |
| 78 | ICK | 0.77376923 |
| 79 | ACVR1B | 0.75105138 |
| 80 | CDK4 | 0.74633345 |
| 81 | LRRK2 | 0.73397282 |
| 82 | MAP3K11 | 0.71613212 |
| 83 | MTOR | 0.71270281 |
| 84 | MAPK12 | 0.70696696 |
| 85 | FLT3 | 0.69760596 |
| 86 | FRK | 0.68759550 |
| 87 | NEK9 | 0.67377862 |
| 88 | CAMKK2 | 0.67034468 |
| 89 | MAPK7 | 0.67009883 |
| 90 | GRK7 | 0.65245621 |
| 91 | CDK9 | 0.62701353 |
| 92 | MAP3K1 | 0.61645431 |
| 93 | ALK | 0.61465284 |
| 94 | PDGFRB | 0.60119068 |
| 95 | PDK1 | 0.59742319 |
| 96 | PRKAA2 | 0.59701948 |
| 97 | AKT3 | 0.59689004 |
| 98 | EGFR | 0.59209852 |
| 99 | TRPM7 | 0.58640007 |
| 100 | RET | 0.54906024 |
| 101 | MAP3K5 | 0.54103071 |
| 102 | PTK2B | 0.53800671 |
| 103 | LYN | 0.53397174 |
| 104 | MAP3K7 | 0.53352960 |
| 105 | PRKCH | 0.52603148 |
| 106 | DMPK | 0.50211139 |
| 107 | TTN | 0.50139261 |
| 108 | PRKCQ | 0.49914471 |
| 109 | ABL1 | 0.48537254 |
| 110 | TEC | 0.47955201 |
| 111 | TAOK1 | 0.47251829 |
| 112 | KSR1 | 0.45967564 |
| 113 | NEK2 | 0.45818721 |
| 114 | MAPK11 | 0.44916297 |
| 115 | SIK3 | 0.44909842 |
| 116 | CAMK4 | 0.44846835 |
| 117 | SGK223 | 0.43768127 |
| 118 | SGK494 | 0.43768127 |
| 119 | SGK3 | 0.43583711 |
| 120 | MAP2K6 | 0.42816538 |
| 121 | MAP3K6 | 0.42577891 |
| 122 | DYRK1B | 0.40912370 |
| 123 | NEK6 | 0.40494334 |
| 124 | MAP2K3 | 0.40437032 |
| 125 | PDK4 | 0.40226839 |
| 126 | PDK3 | 0.40226839 |
| 127 | SGK1 | 0.39912615 |
| 128 | MELK | 0.39374023 |
| 129 | IRAK2 | 0.38567484 |
| 130 | STK38 | 0.36766757 |
| 131 | PTK2 | 0.36437987 |
| 132 | BMPR2 | 0.33152738 |
| 133 | PDPK1 | 0.31895669 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.95632570 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 2.29522784 |
| 3 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.25744032 |
| 4 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.16648200 |
| 5 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.14876885 |
| 6 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.11842227 |
| 7 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.11286868 |
| 8 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.96983791 |
| 9 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.89743275 |
| 10 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.89083985 |
| 11 | Measles_Homo sapiens_hsa05162 | 1.88016564 |
| 12 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.81244954 |
| 13 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.76905305 |
| 14 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.76060059 |
| 15 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.66704328 |
| 16 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.66354900 |
| 17 | Influenza A_Homo sapiens_hsa05164 | 1.65027775 |
| 18 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.59208722 |
| 19 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.58096668 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.54915414 |
| 21 | Legionellosis_Homo sapiens_hsa05134 | 1.54594337 |
| 22 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.53780797 |
| 23 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.46082493 |
| 24 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.44162435 |
| 25 | Tuberculosis_Homo sapiens_hsa05152 | 1.41375162 |
| 26 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.37541543 |
| 27 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.37266295 |
| 28 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.35230101 |
| 29 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.34438910 |
| 30 | Allograft rejection_Homo sapiens_hsa05330 | 1.29235941 |
| 31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.26162036 |
| 32 | Lysine degradation_Homo sapiens_hsa00310 | 1.23422958 |
| 33 | Pertussis_Homo sapiens_hsa05133 | 1.22377513 |
| 34 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.21092373 |
| 35 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.21059625 |
| 36 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.18826537 |
| 37 | Malaria_Homo sapiens_hsa05144 | 1.16410729 |
| 38 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.16398537 |
| 39 | Insulin resistance_Homo sapiens_hsa04931 | 1.15467723 |
| 40 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10949749 |
| 41 | ABC transporters_Homo sapiens_hsa02010 | 1.09876437 |
| 42 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.09836381 |
| 43 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.05424139 |
| 44 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.04130022 |
| 45 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.04122603 |
| 46 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.03204320 |
| 47 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.02694091 |
| 48 | Hepatitis B_Homo sapiens_hsa05161 | 1.02575263 |
| 49 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.01987483 |
| 50 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.00971579 |
| 51 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.00322297 |
| 52 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.99198469 |
| 53 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.97425219 |
| 54 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.97188608 |
| 55 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.96681017 |
| 56 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.93873766 |
| 57 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.93756104 |
| 58 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.92386383 |
| 59 | Hepatitis C_Homo sapiens_hsa05160 | 0.91668055 |
| 60 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.90973914 |
| 61 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.88560555 |
| 62 | Lysosome_Homo sapiens_hsa04142 | 0.88450481 |
| 63 | Apoptosis_Homo sapiens_hsa04210 | 0.88261225 |
| 64 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.86094398 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.85954178 |
| 66 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.83858804 |
| 67 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.83590045 |
| 68 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.82482624 |
| 69 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.81277377 |
| 70 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.77807890 |
| 71 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.74838825 |
| 72 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73887766 |
| 73 | Viral myocarditis_Homo sapiens_hsa05416 | 0.72979080 |
| 74 | Asthma_Homo sapiens_hsa05310 | 0.72368475 |
| 75 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.72199096 |
| 76 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.71046115 |
| 77 | Salmonella infection_Homo sapiens_hsa05132 | 0.70668547 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.70221832 |
| 79 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.68941745 |
| 80 | Prion diseases_Homo sapiens_hsa05020 | 0.67670783 |
| 81 | Endometrial cancer_Homo sapiens_hsa05213 | 0.67239125 |
| 82 | Amoebiasis_Homo sapiens_hsa05146 | 0.65715034 |
| 83 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.63991896 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.63610777 |
| 85 | Histidine metabolism_Homo sapiens_hsa00340 | 0.62111917 |
| 86 | Bile secretion_Homo sapiens_hsa04976 | 0.61139659 |
| 87 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.61120745 |
| 88 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.60349917 |
| 89 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.59826099 |
| 90 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.59129032 |
| 91 | Shigellosis_Homo sapiens_hsa05131 | 0.58362443 |
| 92 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.56799660 |
| 93 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.56618241 |
| 94 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.54823153 |
| 95 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.54327427 |
| 96 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.53461653 |
| 97 | Peroxisome_Homo sapiens_hsa04146 | 0.52406501 |
| 98 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.50935688 |
| 99 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.50650675 |
| 100 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50319358 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.49967325 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.48172661 |
| 103 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.47998315 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.47481595 |
| 105 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47240020 |
| 106 | Platelet activation_Homo sapiens_hsa04611 | 0.45812145 |
| 107 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.44859689 |
| 108 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.44283563 |
| 109 | Glioma_Homo sapiens_hsa05214 | 0.44209195 |
| 110 | Phagosome_Homo sapiens_hsa04145 | 0.43160572 |
| 111 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.42674928 |
| 112 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.42664712 |
| 113 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.42627836 |
| 114 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.42462232 |
| 115 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.42216935 |
| 116 | Circadian rhythm_Homo sapiens_hsa04710 | 0.42103910 |
| 117 | Endocytosis_Homo sapiens_hsa04144 | 0.40342386 |
| 118 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.39487682 |
| 119 | Prostate cancer_Homo sapiens_hsa05215 | 0.39035224 |
| 120 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.38967230 |
| 121 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37247030 |
| 122 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.37108006 |
| 123 | Adherens junction_Homo sapiens_hsa04520 | 0.37096351 |
| 124 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.35604088 |
| 125 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.35086531 |
| 126 | Other glycan degradation_Homo sapiens_hsa00511 | 0.33518562 |
| 127 | HTLV-I infection_Homo sapiens_hsa05166 | 0.33079521 |

