ZCCHC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.71049000
2paraxial mesoderm development (GO:0048339)4.70268706
3mitotic metaphase plate congression (GO:0007080)4.38699268
4viral transcription (GO:0019083)4.28444043
5DNA topological change (GO:0006265)4.20473119
6negative regulation of mRNA metabolic process (GO:1903312)4.20222900
7translational termination (GO:0006415)4.09211301
8regulation of histone H3-K9 methylation (GO:0051570)4.00218727
9regulation of gene silencing by miRNA (GO:0060964)3.94573568
10regulation of gene silencing by RNA (GO:0060966)3.94573568
11regulation of posttranscriptional gene silencing (GO:0060147)3.94573568
12DNA unwinding involved in DNA replication (GO:0006268)3.92625910
13metaphase plate congression (GO:0051310)3.84614843
14ribosomal small subunit assembly (GO:0000028)3.82907594
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78163874
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73278354
17pre-miRNA processing (GO:0031054)3.70144222
18regulation of RNA export from nucleus (GO:0046831)3.69421422
19protein localization to kinetochore (GO:0034501)3.68410708
20regulation of chromatin binding (GO:0035561)3.68233773
21V(D)J recombination (GO:0033151)3.65537916
22mRNA stabilization (GO:0048255)3.65277912
23RNA stabilization (GO:0043489)3.65277912
24DNA replication checkpoint (GO:0000076)3.64330832
25nucleosome disassembly (GO:0006337)3.59661063
26protein-DNA complex disassembly (GO:0032986)3.59661063
27establishment of chromosome localization (GO:0051303)3.55563821
28DNA replication initiation (GO:0006270)3.53752882
29DNA replication-dependent nucleosome organization (GO:0034723)3.51553735
30DNA replication-dependent nucleosome assembly (GO:0006335)3.51553735
31mitotic nuclear envelope disassembly (GO:0007077)3.44940535
32DNA strand elongation involved in DNA replication (GO:0006271)3.44213470
33kinetochore organization (GO:0051383)3.43944232
34kinetochore assembly (GO:0051382)3.39092840
35translational elongation (GO:0006414)3.38136077
36mitotic chromosome condensation (GO:0007076)3.35353978
37regulation of NFAT protein import into nucleus (GO:0051532)3.31316479
38chromatin assembly (GO:0031497)3.29361957
39CENP-A containing nucleosome assembly (GO:0034080)3.27553869
40chromatin remodeling at centromere (GO:0031055)3.25394424
41DNA strand elongation (GO:0022616)3.25094620
42regulation of mRNA stability (GO:0043488)3.24273474
43proline biosynthetic process (GO:0006561)3.23908507
44mitotic sister chromatid segregation (GO:0000070)3.23415055
45mitotic sister chromatid cohesion (GO:0007064)3.22957208
46sister chromatid segregation (GO:0000819)3.22403542
47DNA replication-independent nucleosome organization (GO:0034724)3.22039512
48DNA replication-independent nucleosome assembly (GO:0006336)3.22039512
49spindle checkpoint (GO:0031577)3.20200960
50regulation of spindle organization (GO:0090224)3.20180866
51nuclear pore organization (GO:0006999)3.20033736
52protein localization to chromosome, centromeric region (GO:0071459)3.19492346
53nuclear envelope disassembly (GO:0051081)3.18577716
54membrane disassembly (GO:0030397)3.18577716
55negative regulation of chromosome segregation (GO:0051985)3.18549291
56regulation of translational fidelity (GO:0006450)3.18269898
57termination of RNA polymerase II transcription (GO:0006369)3.18222088
58translational initiation (GO:0006413)3.17850729
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17153269
603-UTR-mediated mRNA stabilization (GO:0070935)3.16858035
61viral life cycle (GO:0019058)3.15574414
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15505394
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15505394
64negative regulation of sister chromatid segregation (GO:0033046)3.15505394
65negative regulation of mitotic sister chromatid separation (GO:2000816)3.15505394
66mitotic spindle checkpoint (GO:0071174)3.14701374
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12965546
68peptidyl-arginine omega-N-methylation (GO:0035247)3.11689598
69attachment of spindle microtubules to kinetochore (GO:0008608)3.11647992
70mitotic spindle assembly checkpoint (GO:0007094)3.11576470
71spliceosomal snRNP assembly (GO:0000387)3.11213774
72protein complex disassembly (GO:0043241)3.08716214
73spindle assembly checkpoint (GO:0071173)3.08527923
74notochord development (GO:0030903)3.08021214
75regulation of RNA stability (GO:0043487)3.07822245
76protein targeting to ER (GO:0045047)3.07506563
77cellular protein complex disassembly (GO:0043624)3.06613965
78cotranslational protein targeting to membrane (GO:0006613)3.03873448
79histone exchange (GO:0043486)3.02675944
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02567177
81protein K6-linked ubiquitination (GO:0085020)3.01541544
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99468920
83regulation of chromosome segregation (GO:0051983)2.97930514
84histone arginine methylation (GO:0034969)2.97761988
85spliceosomal complex assembly (GO:0000245)2.96850030
86histone H2A acetylation (GO:0043968)2.95888472
87formation of translation preinitiation complex (GO:0001731)2.93779072
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93338930
89positive regulation by host of viral transcription (GO:0043923)2.92974297
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91809029
91regulation of sister chromatid cohesion (GO:0007063)2.91616062
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91520460
93telomere maintenance via semi-conservative replication (GO:0032201)2.91375234
94protein complex localization (GO:0031503)2.90198394
95maturation of SSU-rRNA (GO:0030490)2.89857150
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89448457
97DNA duplex unwinding (GO:0032508)2.89179551
98nucleobase biosynthetic process (GO:0046112)2.86608004
99chromosome condensation (GO:0030261)2.86470494
100regulation of stem cell maintenance (GO:2000036)2.85761401
101establishment of integrated proviral latency (GO:0075713)2.83487101
102regulation of nucleobase-containing compound transport (GO:0032239)2.83459383
103positive regulation of chromosome segregation (GO:0051984)2.83285667
104spliceosomal tri-snRNP complex assembly (GO:0000244)2.82625854
105regulation of mitotic sister chromatid separation (GO:0010965)2.81760619
106regulation of mitotic sister chromatid segregation (GO:0033047)2.81760619
107regulation of sister chromatid segregation (GO:0033045)2.81760619
108peptidyl-arginine methylation (GO:0018216)2.80622564
109peptidyl-arginine N-methylation (GO:0035246)2.80622564
110nuclear pore complex assembly (GO:0051292)2.80408498
111ribonucleoprotein complex biogenesis (GO:0022613)2.78109040
112regulation of telomere maintenance via telomerase (GO:0032210)2.77900116
113negative regulation of histone methylation (GO:0031061)2.77554342
114ribosomal large subunit biogenesis (GO:0042273)2.76948966
115macromolecular complex disassembly (GO:0032984)2.76625243
116ATP-dependent chromatin remodeling (GO:0043044)2.76439520
117IMP biosynthetic process (GO:0006188)2.75534895
118chromatin assembly or disassembly (GO:0006333)2.74865030
119folic acid-containing compound biosynthetic process (GO:0009396)2.73990049
120protein localization to endoplasmic reticulum (GO:0070972)2.73392114
121DNA geometric change (GO:0032392)2.73269134
122cellular protein complex localization (GO:0034629)2.72459473
123RNA splicing, via transesterification reactions (GO:0000375)2.72196011
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70809745
125mRNA splicing, via spliceosome (GO:0000398)2.70809745
126chromosome segregation (GO:0007059)2.70208600
127protein localization to chromosome (GO:0034502)2.69878075
128nuclear-transcribed mRNA catabolic process (GO:0000956)2.69459197
129regulation of centrosome cycle (GO:0046605)2.68091031
130DNA synthesis involved in DNA repair (GO:0000731)2.67391620
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66305977
132regulation of mitotic spindle organization (GO:0060236)2.65675301
133purine nucleobase biosynthetic process (GO:0009113)2.65539892
134DNA conformation change (GO:0071103)2.65440596
135mRNA transport (GO:0051028)2.64976213
136pore complex assembly (GO:0046931)2.64180956
137negative regulation of mRNA processing (GO:0050686)2.63225725
138negative regulation of mitosis (GO:0045839)2.63112168
139histone H2A monoubiquitination (GO:0035518)2.62584650
140viral mRNA export from host cell nucleus (GO:0046784)2.62450449
141telomere maintenance via recombination (GO:0000722)2.62376776
142mitotic G2/M transition checkpoint (GO:0044818)2.62337005
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.62243710
144ribosome biogenesis (GO:0042254)2.61866371
145heterochromatin organization (GO:0070828)2.61646636
146mitotic recombination (GO:0006312)2.60680241
147RNA catabolic process (GO:0006401)2.60612053
148base-excision repair (GO:0006284)2.59920581
149negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59848096
150negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59848096
151body morphogenesis (GO:0010171)2.59458558
152mRNA catabolic process (GO:0006402)2.58201571
153positive regulation of gene expression, epigenetic (GO:0045815)2.57380801
154regulation of histone methylation (GO:0031060)2.56526523
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56232108
156negative regulation of RNA splicing (GO:0033119)2.54989790
157mismatch repair (GO:0006298)2.54056112
158intra-S DNA damage checkpoint (GO:0031573)2.53749220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97751134
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77610346
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.27059141
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80741517
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.65486645
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08069422
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89793959
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87102529
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.75458319
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70639618
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68356196
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64580492
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.52101390
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.50225632
15VDR_21846776_ChIP-Seq_THP-1_Human2.49160070
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48276151
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.40474982
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34049764
19XRN2_22483619_ChIP-Seq_HELA_Human2.33077374
20AR_21909140_ChIP-Seq_LNCAP_Human2.30918527
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30748791
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30236697
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29339756
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22524756
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21197441
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18868689
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06114698
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.02722032
29* TTF2_22483619_ChIP-Seq_HELA_Human2.00912013
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99679859
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97932665
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94729744
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.90126572
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88692845
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88535177
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87511147
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85871738
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80191588
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79213230
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77102846
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76340717
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75130729
43GABP_19822575_ChIP-Seq_HepG2_Human1.74742624
44* CIITA_25753668_ChIP-Seq_RAJI_Human1.71402020
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68966713
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65586209
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64717704
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64717704
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64717704
50DCP1A_22483619_ChIP-Seq_HELA_Human1.63669772
51VDR_23849224_ChIP-Seq_CD4+_Human1.63332310
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62864255
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62010204
54* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60351013
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59433201
56FOXP3_21729870_ChIP-Seq_TREG_Human1.59270261
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58888473
58TCF7_22412390_ChIP-Seq_EML_Mouse1.57697513
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55893868
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53627948
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52686074
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49114296
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47773277
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.47642266
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.46827758
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46651140
67ZNF263_19887448_ChIP-Seq_K562_Human1.45709708
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.39660753
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37728263
70KDM2B_26808549_Chip-Seq_DND41_Human1.33869805
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30454994
72KDM5A_27292631_Chip-Seq_BREAST_Human1.30443299
73MYC_18940864_ChIP-ChIP_HL60_Human1.29225150
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28998220
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27926891
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26722120
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26646911
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26138479
79ELK1_19687146_ChIP-ChIP_HELA_Human1.22858891
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22338225
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20741849
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20097704
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19902241
84* SOX2_16153702_ChIP-ChIP_HESCs_Human1.19726652
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18110696
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18025132
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17381236
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15766271
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15400031
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15107085
91* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15057871
92* MYC_22102868_ChIP-Seq_BL_Human1.11522390
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11217352
94* MAF_26560356_Chip-Seq_TH1_Human1.10699163
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10264455
96VDR_24763502_ChIP-Seq_THP-1_Human1.09875983
97* NANOG_16153702_ChIP-ChIP_HESCs_Human1.08727732
98NCOR1_26117541_ChIP-Seq_K562_Human1.08214760
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08003442
100UTX_26944678_Chip-Seq_JUKART_Human1.07821918
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06017913
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05413443
103* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03972180
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02879046
105LXR_22292898_ChIP-Seq_THP-1_Human1.02757577
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01969927
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01663615
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01164349
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00835219
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00347930
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00240720
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98789892
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98657092
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98419794
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98369031
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.97669847
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96907815
118RACK7_27058665_Chip-Seq_MCF-7_Human0.96848188
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96062423
120* CHD1_26751641_Chip-Seq_LNCaP_Human0.95686192
121KDM2B_26808549_Chip-Seq_K562_Human0.95576271
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95565802
123MAF_26560356_Chip-Seq_TH2_Human0.95438036
124* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91819712
125SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91209093
126POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91064388
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90057901
128* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89569290
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87015209
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86946214
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86857468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.63043662
2MP0003693_abnormal_embryo_hatching3.56210720
3MP0004957_abnormal_blastocyst_morpholog3.10801298
4MP0003111_abnormal_nucleus_morphology3.08981577
5MP0010030_abnormal_orbit_morphology3.08890279
6MP0010094_abnormal_chromosome_stability3.05556748
7MP0003077_abnormal_cell_cycle2.86301275
8MP0002653_abnormal_ependyma_morphology2.74192071
9MP0003121_genomic_imprinting2.68876262
10MP0003122_maternal_imprinting2.48060460
11MP0002396_abnormal_hematopoietic_system2.46240415
12MP0008932_abnormal_embryonic_tissue2.31092634
13MP0009278_abnormal_bone_marrow2.25971835
14MP0005451_abnormal_body_composition2.25224435
15MP0008057_abnormal_DNA_replication2.23145833
16MP0008877_abnormal_DNA_methylation2.18963734
17MP0006292_abnormal_olfactory_placode2.14704077
18MP0008007_abnormal_cellular_replicative2.14663041
19MP0008058_abnormal_DNA_repair2.01133251
20MP0003119_abnormal_digestive_system1.99820677
21MP0009053_abnormal_anal_canal1.98562739
22MP0001730_embryonic_growth_arrest1.97876069
23MP0003937_abnormal_limbs/digits/tail_de1.93180643
24MP0002085_abnormal_embryonic_tissue1.89244531
25MP0000537_abnormal_urethra_morphology1.85834617
26MP0003890_abnormal_embryonic-extraembry1.85543306
27MP0003315_abnormal_perineum_morphology1.82901312
28MP0003942_abnormal_urinary_system1.79952943
29MP0001293_anophthalmia1.79540776
30MP0001672_abnormal_embryogenesis/_devel1.77677064
31MP0005380_embryogenesis_phenotype1.77677064
32MP0002084_abnormal_developmental_patter1.77407576
33MP0003941_abnormal_skin_development1.75932946
34MP0009379_abnormal_foot_pigmentation1.73977800
35MP0000049_abnormal_middle_ear1.73625866
36MP0000350_abnormal_cell_proliferation1.71460004
37MP0001697_abnormal_embryo_size1.69129049
38MP0003567_abnormal_fetal_cardiomyocyte1.67369069
39MP0000566_synostosis1.67208762
40MP0001346_abnormal_lacrimal_gland1.65932474
41MP0002089_abnormal_postnatal_growth/wei1.65287626
42MP0004185_abnormal_adipocyte_glucose1.63934455
43MP0002249_abnormal_larynx_morphology1.63305096
44MP0001849_ear_inflammation1.60990871
45MP0004133_heterotaxia1.60129183
46MP0003984_embryonic_growth_retardation1.55127001
47MP0002088_abnormal_embryonic_growth/wei1.53229168
48MP0002938_white_spotting1.48792362
49MP0002132_abnormal_respiratory_system1.47122670
50MP0003385_abnormal_body_wall1.42368887
51MP0000490_abnormal_crypts_of1.38123740
52MP0004264_abnormal_extraembryonic_tissu1.37514022
53MP0004197_abnormal_fetal_growth/weight/1.36557112
54MP0004808_abnormal_hematopoietic_stem1.36480679
55MP0002080_prenatal_lethality1.33482872
56MP0003718_maternal_effect1.31401744
57MP0003935_abnormal_craniofacial_develop1.30932159
58MP0000428_abnormal_craniofacial_morphol1.30525573
59MP0002932_abnormal_joint_morphology1.27737078
60MP0008789_abnormal_olfactory_epithelium1.26808836
61MP0003861_abnormal_nervous_system1.25817577
62MP0003938_abnormal_ear_development1.24100390
63MP0002086_abnormal_extraembryonic_tissu1.22832510
64MP0003755_abnormal_palate_morphology1.21654314
65MP0009672_abnormal_birth_weight1.20524222
66MP0000703_abnormal_thymus_morphology1.19943375
67MP0001286_abnormal_eye_development1.19694451
68MP0002102_abnormal_ear_morphology1.16489369
69MP0009250_abnormal_appendicular_skeleto1.14657804
70MP0002210_abnormal_sex_determination1.11953292
71MP0002111_abnormal_tail_morphology1.11628616
72MP0000534_abnormal_ureter_morphology1.10259540
73MP0002116_abnormal_craniofacial_bone1.09988259
74MP0002282_abnormal_trachea_morphology1.09919887
75MP0000631_abnormal_neuroendocrine_gland1.08653084
76MP0003705_abnormal_hypodermis_morpholog1.08240480
77MP0005220_abnormal_exocrine_pancreas1.07973815
78MP0002254_reproductive_system_inflammat1.07917598
79MP0001915_intracranial_hemorrhage1.07704697
80MP0002233_abnormal_nose_morphology1.07630629
81MP0002697_abnormal_eye_size1.07229013
82MP0003943_abnormal_hepatobiliary_system1.03896118
83MP0002751_abnormal_autonomic_nervous1.02914067
84MP0000432_abnormal_head_morphology1.02535787
85MP0003303_peritoneal_inflammation1.02103094
86MP0003283_abnormal_digestive_organ1.02040811
87MP0003950_abnormal_plasma_membrane1.01724185
88MP0002127_abnormal_cardiovascular_syste1.01684517
89MP0003787_abnormal_imprinting1.00924443
90MP0002163_abnormal_gland_morphology1.00905389
91MP0009333_abnormal_splenocyte_physiolog1.00630572
92MP0001545_abnormal_hematopoietic_system0.99981864
93MP0005397_hematopoietic_system_phenotyp0.99981864
94MP0009703_decreased_birth_body0.98072916
95MP0004233_abnormal_muscle_weight0.97979081
96MP0002114_abnormal_axial_skeleton0.97264481
97MP0003115_abnormal_respiratory_system0.97173161
98MP0000678_abnormal_parathyroid_gland0.94996806
99MP0002398_abnormal_bone_marrow0.94486021
100MP0001145_abnormal_male_reproductive0.91913172
101MP0002160_abnormal_reproductive_system0.91396792
102MP0002019_abnormal_tumor_incidence0.90934953
103MP0005076_abnormal_cell_differentiation0.90518681
104MP0005623_abnormal_meninges_morphology0.89948659
105MP0000313_abnormal_cell_death0.89295017
106MP0005499_abnormal_olfactory_system0.88139437
107MP0005394_taste/olfaction_phenotype0.88139437
108MP0002092_abnormal_eye_morphology0.87569006
109MP0002234_abnormal_pharynx_morphology0.86848866
110MP0000653_abnormal_sex_gland0.86478541
111MP0002722_abnormal_immune_system0.84737557
112MP0001119_abnormal_female_reproductive0.82173787
113MP0002925_abnormal_cardiovascular_devel0.81943758
114MP0006072_abnormal_retinal_apoptosis0.81121816
115MP0010630_abnormal_cardiac_muscle0.80740416
116MP0003786_premature_aging0.80398913
117MP0010352_gastrointestinal_tract_polyps0.79837359
118MP0005187_abnormal_penis_morphology0.79744896
119MP0003878_abnormal_ear_physiology0.79709605
120MP0005377_hearing/vestibular/ear_phenot0.79709605
121MP0000516_abnormal_urinary_system0.79288304
122MP0005367_renal/urinary_system_phenotyp0.79288304
123MP0001929_abnormal_gametogenesis0.79001448
124MP0005248_abnormal_Harderian_gland0.78217746
125MP0010307_abnormal_tumor_latency0.77841595
126MP0002166_altered_tumor_susceptibility0.77480464
127MP0002638_abnormal_pupillary_reflex0.77197844
128MP0002177_abnormal_outer_ear0.76155990
129MP0000689_abnormal_spleen_morphology0.75508375
130MP0004145_abnormal_muscle_electrophysio0.75347574
131MP0002081_perinatal_lethality0.74701076
132MP0004084_abnormal_cardiac_muscle0.74655067
133MP0002009_preneoplasia0.72303972
134MP0002006_tumorigenesis0.67700659

Predicted human phenotypes

RankGene SetZ-score
1Patellar aplasia (HP:0006443)3.39822442
2Aplasia/Hypoplasia of the patella (HP:0006498)3.31000959
3Breast hypoplasia (HP:0003187)3.29379231
4Supernumerary spleens (HP:0009799)3.21355010
511 pairs of ribs (HP:0000878)3.18713309
6Birth length less than 3rd percentile (HP:0003561)3.11205594
7Ependymoma (HP:0002888)3.10156326
8Rhabdomyosarcoma (HP:0002859)3.03334884
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00857112
10Short 4th metacarpal (HP:0010044)3.00857112
11Multiple enchondromatosis (HP:0005701)2.97443365
12Abnormality of the labia minora (HP:0012880)2.96563432
13Abnormality of the astrocytes (HP:0100707)2.93655838
14Astrocytoma (HP:0009592)2.93655838
15Deep venous thrombosis (HP:0002625)2.93163833
16Abnormal lung lobation (HP:0002101)2.90002106
17Colon cancer (HP:0003003)2.86965742
18Neoplasm of striated muscle (HP:0009728)2.85473835
19Abnormality of cells of the erythroid lineage (HP:0012130)2.82472072
20Medulloblastoma (HP:0002885)2.80548144
21Partial duplication of thumb phalanx (HP:0009944)2.79863873
22Absent radius (HP:0003974)2.72091616
23Renal duplication (HP:0000075)2.71844620
24Shawl scrotum (HP:0000049)2.67469516
25Hepatoblastoma (HP:0002884)2.60680379
26Abnormality of abdominal situs (HP:0011620)2.59745606
27Abdominal situs inversus (HP:0003363)2.59745606
28High anterior hairline (HP:0009890)2.58725219
29Glioma (HP:0009733)2.57593039
30Midline defect of the nose (HP:0004122)2.56642689
31Meckel diverticulum (HP:0002245)2.55027386
32Aplasia involving forearm bones (HP:0009822)2.54180182
33Absent forearm bone (HP:0003953)2.54180182
34Ectopic kidney (HP:0000086)2.54019940
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53474383
36Partial duplication of the phalanx of hand (HP:0009999)2.53254893
37Panhypogammaglobulinemia (HP:0003139)2.53085551
38Rib fusion (HP:0000902)2.51737556
39Chromsome breakage (HP:0040012)2.51408530
40Reticulocytopenia (HP:0001896)2.49949027
41Vaginal fistula (HP:0004320)2.48845852
42Selective tooth agenesis (HP:0001592)2.48716540
43Asymmetry of the thorax (HP:0001555)2.48615915
44Abnormal number of incisors (HP:0011064)2.48548727
45B lymphocytopenia (HP:0010976)2.47774558
46Anal stenosis (HP:0002025)2.45968991
47Abnormality of the ileum (HP:0001549)2.44184457
48Abnormal number of erythroid precursors (HP:0012131)2.43809853
49Overlapping toe (HP:0001845)2.38616511
50Abnormal tarsal ossification (HP:0008369)2.36636246
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.34968319
52Nephroblastoma (Wilms tumor) (HP:0002667)2.32896967
53Acute lymphatic leukemia (HP:0006721)2.32800629
54Progressive external ophthalmoplegia (HP:0000590)2.32643880
55Broad distal phalanx of finger (HP:0009836)2.32414710
56Abnormality of the 4th metacarpal (HP:0010012)2.30913166
57Atresia of the external auditory canal (HP:0000413)2.30091391
58Rectal prolapse (HP:0002035)2.29995523
59Rectal fistula (HP:0100590)2.27356299
60Rectovaginal fistula (HP:0000143)2.27356299
61Broad palm (HP:0001169)2.25918399
62Bifid tongue (HP:0010297)2.25410434
63Carpal bone hypoplasia (HP:0001498)2.24061347
64Intestinal fistula (HP:0100819)2.22612926
65Pallor (HP:0000980)2.20650453
66Small epiphyses (HP:0010585)2.20417422
67Intestinal atresia (HP:0011100)2.19633655
68Embryonal renal neoplasm (HP:0011794)2.18790278
69Diastasis recti (HP:0001540)2.16932661
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.16374703
71Hypoplasia of the thymus (HP:0000778)2.14892316
72Trigonocephaly (HP:0000243)2.14729331
73Macrocytic anemia (HP:0001972)2.14174625
74Progressive muscle weakness (HP:0003323)2.12641055
75Dysphonia (HP:0001618)2.12109813
76Deep palmar crease (HP:0006191)2.10001957
77Disproportionate tall stature (HP:0001519)2.09211019
78Impulsivity (HP:0100710)2.07574539
79Squamous cell carcinoma (HP:0002860)2.05148419
80Horseshoe kidney (HP:0000085)2.05132496
81Small intestinal stenosis (HP:0012848)2.04850107
82Duodenal stenosis (HP:0100867)2.04850107
83Triphalangeal thumb (HP:0001199)2.02470235
84Increased nuchal translucency (HP:0010880)2.02167124
85Embryonal neoplasm (HP:0002898)2.02124509
86Gastrointestinal carcinoma (HP:0002672)2.01531806
87Malignant gastrointestinal tract tumors (HP:0006749)2.01531806
88Abnormal foot bone ossification (HP:0010675)1.99992876
89Abnormality of the lacrimal duct (HP:0011481)1.97844207
90Pseudobulbar signs (HP:0002200)1.96433039
91Irregular epiphyses (HP:0010582)1.96352259
92Choanal stenosis (HP:0000452)1.95790868
93Broad alveolar ridges (HP:0000187)1.95730215
94Duplication of thumb phalanx (HP:0009942)1.95668639
95Abnormality of chromosome segregation (HP:0002916)1.94398762
96Abnormality of the fingertips (HP:0001211)1.94296447
97Myelomeningocele (HP:0002475)1.94055912
98Short middle phalanx of the 5th finger (HP:0004220)1.93227213
99Facial cleft (HP:0002006)1.93060618
100Facial hemangioma (HP:0000329)1.92638703
101Absent thumb (HP:0009777)1.92322833
102Missing ribs (HP:0000921)1.90749644
103Pendular nystagmus (HP:0012043)1.89617918
104Abnormality of the duodenum (HP:0002246)1.88809399
105Neoplasm of the oral cavity (HP:0100649)1.88306529
106Concave nail (HP:0001598)1.88263821
107Supernumerary bones of the axial skeleton (HP:0009144)1.88122328
108Cleft eyelid (HP:0000625)1.87219794
109Abnormality of the parietal bone (HP:0002696)1.85568639
110Arnold-Chiari malformation (HP:0002308)1.84109365
111Generalized hypotonia (HP:0001290)1.82013024
112Abnormality of the renal collecting system (HP:0004742)1.80508775
113Short 5th finger (HP:0009237)1.80376902
114Aplasia/hypoplasia of the humerus (HP:0006507)1.80068062
115Septate vagina (HP:0001153)1.79980693
116Uterine leiomyosarcoma (HP:0002891)1.79924841
117Leiomyosarcoma (HP:0100243)1.79924841
118Oral leukoplakia (HP:0002745)1.79389574
119Supernumerary ribs (HP:0005815)1.79285271
120Broad thumb (HP:0011304)1.79266066
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.77671490
122Abnormality of the preputium (HP:0100587)1.77370049
123Abnormality of reticulocytes (HP:0004312)1.76978956
124Abnormality of the incisor (HP:0000676)1.76387167
125Skin tags (HP:0010609)1.76092831
126Abnormality of endocrine pancreas physiology (HP:0012093)1.75706650
127Abnormality of the pancreatic islet cells (HP:0006476)1.75706650
128Aplasia/Hypoplasia of the breasts (HP:0010311)1.75689716
129Neoplasm of the pancreas (HP:0002894)1.75520582
130Skull defect (HP:0001362)1.75439673
131Abnormality of chromosome stability (HP:0003220)1.75133216
132Broad finger (HP:0001500)1.75063832
133Tracheoesophageal fistula (HP:0002575)1.74384906
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74176770
135Duplicated collecting system (HP:0000081)1.74157049
136Abnormality of the aortic arch (HP:0012303)1.73895915
137Abnormality of B cell number (HP:0010975)1.73753908
138Broad toe (HP:0001837)1.73517513
139Abnormal vertebral ossification (HP:0100569)1.73210402
140Absent epiphyses (HP:0010577)1.72469215
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72469215
142Abnormal ventriculo-arterial connection (HP:0011563)1.72046123
143Transposition of the great arteries (HP:0001669)1.72046123
144Abnormal connection of the cardiac segments (HP:0011545)1.72046123
145Benign neoplasm of the central nervous system (HP:0100835)1.71635606
146Long palpebral fissure (HP:0000637)1.71566188
147Abnormality of the thoracic spine (HP:0100711)1.71462885
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71254008
149Abnormality of cochlea (HP:0000375)1.71197044
150Abnormality of the phalanges of the hallux (HP:0010057)1.71032694
151Oligodactyly (HP:0012165)1.70486360
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70454872
153Thin ribs (HP:0000883)1.68958937
154Proximal placement of thumb (HP:0009623)1.67782344
155Capillary hemangiomas (HP:0005306)1.67384391
156Broad phalanges of the hand (HP:0009768)1.67012032
157Abnormality of carpal bone ossification (HP:0006257)1.66980029
158Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66793332
159Deviation of the thumb (HP:0009603)1.66666327
160Gastrointestinal atresia (HP:0002589)1.66087107
161Abnormality of the thymus (HP:0000777)1.66025004
162Hemivertebrae (HP:0002937)1.65522900
163Abnormal sex determination (HP:0012244)1.65502004
164Sex reversal (HP:0012245)1.65502004
165Anophthalmia (HP:0000528)1.65501192
166Preauricular skin tag (HP:0000384)1.64832741
167Septo-optic dysplasia (HP:0100842)1.64002831
168Hypoplastic pelvis (HP:0008839)1.63869688
169Degeneration of anterior horn cells (HP:0002398)1.63652102
170Abnormality of the anterior horn cell (HP:0006802)1.63652102
171Breast aplasia (HP:0100783)1.62939237
172Cerebral hypomyelination (HP:0006808)1.62111158
173Short thumb (HP:0009778)1.62026887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.81727439
2CDC73.93233881
3SMG13.86858616
4PRPF4B3.71912852
5BUB13.67084443
6WEE13.13138966
7SRPK12.76648924
8LATS22.70856517
9EEF2K2.56877021
10TTK2.47368678
11TAF12.43535927
12NEK22.37131775
13MKNK12.34554794
14CDK122.30368046
15STK38L2.27578157
16TRIB32.15634976
17TLK12.14247900
18PLK42.12904554
19MKNK22.00873432
20PLK11.98023637
21VRK21.86080016
22FGFR41.81968997
23CDK71.81179148
24PLK31.74520247
25NEK11.58884212
26CHEK21.55325769
27DYRK31.53331569
28MELK1.52491143
29MAP3K101.49067149
30AURKB1.46120301
31PASK1.45240172
32EPHB21.43783094
33AURKA1.42196326
34EIF2AK11.39990491
35TSSK61.36823296
36BRSK21.35572769
37CDK81.33858810
38STK31.32079188
39ATR1.28742022
40NUAK11.28435383
41DYRK21.26724469
42VRK11.25865960
43ACVR1B1.25148812
44BRD41.23880328
45RPS6KA41.20225967
46CHEK11.18913441
47BRAF1.17644406
48MAP3K91.17547678
49CAMK1G1.10235083
50CDK41.08427458
51EPHA21.05540279
52PNCK1.03717154
53BRSK10.99212025
54TGFBR10.96859619
55CAMK1D0.95954488
56MAP3K80.94871751
57FGFR30.93775891
58RPS6KC10.92703006
59RPS6KL10.92703006
60SCYL20.92297888
61CDK20.91568279
62ATM0.89660478
63RPS6KB20.87197258
64FGFR20.86413914
65TESK20.83151828
66STK160.82647647
67PAK40.79927384
68TAOK20.78303860
69CDK10.76296398
70PRKD30.75809530
71DMPK0.71668144
72STK40.71196903
73KSR10.70928957
74RPS6KA60.68600824
75ERN10.68496008
76UHMK10.68335244
77PRKCI0.67880163
78SIK10.67170600
79MAP4K10.66755136
80LRRK20.65505288
81AKT30.64342923
82AKT20.63898936
83IRAK30.60764461
84MAP2K20.60630856
85FGFR10.59251364
86MAP2K30.59147645
87CDK30.58479501
88STK100.58403724
89CSNK1E0.58266001
90MTOR0.57971176
91BCR0.57617271
92TNIK0.56463497
93TYRO30.55869834
94RAF10.55686425
95SIK20.54995950
96NEK90.54391535
97CSNK2A10.53894546
98CLK10.52434851
99DYRK1B0.51763346
100KDR0.50177471
101CSNK2A20.49585765
102MAP3K130.49440847
103PAK10.48950132
104HIPK20.48239888
105ZAK0.48116324
106WNK30.47828107
107ALK0.47737224
108MAP3K60.45809963
109IRAK40.45211871
110EIF2AK20.44196465
111NME10.44044843
112KSR20.43955358
113ICK0.42985662
114MATK0.41841117
115OBSCN0.41700451
116CDK11A0.40205338
117RPS6KB10.39370125
118ILK0.38957465
119CSNK1G10.38771776
120PDGFRA0.38750426
121RPS6KA20.38200199
122ARAF0.37563685
123MAP3K50.37369293
124MAP3K10.37265642
125AKT10.37196978
126ERBB40.35815497
127PRKDC0.35640274
128YES10.35144177
129NME20.34782196
130GSK3B0.33687735
131CDK60.32602360
132RPS6KA50.32144724
133RPS6KA10.32096331
134MAPK140.31988795
135CDK90.30879503
136CSNK1D0.30444993
137CSNK1G30.29320900
138ERBB20.28506817
139MAPK90.27533440
140PKN20.22362880
141MAPK100.21568704
142PIM10.21401138

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35418641
2Mismatch repair_Homo sapiens_hsa034303.71908472
3Spliceosome_Homo sapiens_hsa030403.56262708
4RNA transport_Homo sapiens_hsa030133.26949031
5Base excision repair_Homo sapiens_hsa034103.16184038
6Cell cycle_Homo sapiens_hsa041103.15422011
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10119993
8RNA polymerase_Homo sapiens_hsa030203.09789477
9Nucleotide excision repair_Homo sapiens_hsa034202.79752977
10Homologous recombination_Homo sapiens_hsa034402.75522463
11Ribosome_Homo sapiens_hsa030102.71419816
12mRNA surveillance pathway_Homo sapiens_hsa030152.46561326
13Basal transcription factors_Homo sapiens_hsa030222.39885959
14RNA degradation_Homo sapiens_hsa030182.38184593
15Fanconi anemia pathway_Homo sapiens_hsa034602.23066573
16Basal cell carcinoma_Homo sapiens_hsa052172.18063434
17Proteasome_Homo sapiens_hsa030502.14371377
18One carbon pool by folate_Homo sapiens_hsa006702.14327585
19Pyrimidine metabolism_Homo sapiens_hsa002402.10422558
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80345491
21Hedgehog signaling pathway_Homo sapiens_hsa043401.76836380
22Hippo signaling pathway_Homo sapiens_hsa043901.69297640
23Oocyte meiosis_Homo sapiens_hsa041141.67745479
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64016320
25B cell receptor signaling pathway_Homo sapiens_hsa046621.54695660
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54430127
27Non-homologous end-joining_Homo sapiens_hsa034501.42704141
28p53 signaling pathway_Homo sapiens_hsa041151.39987774
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37886792
30Primary immunodeficiency_Homo sapiens_hsa053401.29607108
31Pancreatic cancer_Homo sapiens_hsa052121.26755329
32Purine metabolism_Homo sapiens_hsa002301.21593746
33Wnt signaling pathway_Homo sapiens_hsa043101.18325316
34Notch signaling pathway_Homo sapiens_hsa043301.17033860
35TGF-beta signaling pathway_Homo sapiens_hsa043501.16617310
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14598727
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11282629
38MicroRNAs in cancer_Homo sapiens_hsa052061.10892185
39Thyroid cancer_Homo sapiens_hsa052161.06952819
40Epstein-Barr virus infection_Homo sapiens_hsa051691.01159237
41Steroid biosynthesis_Homo sapiens_hsa001000.97170027
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96655564
43HTLV-I infection_Homo sapiens_hsa051660.94914979
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89845782
45Huntingtons disease_Homo sapiens_hsa050160.81277218
46Adherens junction_Homo sapiens_hsa045200.80730929
47Tight junction_Homo sapiens_hsa045300.78830387
48Colorectal cancer_Homo sapiens_hsa052100.75965233
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.74961942
50ErbB signaling pathway_Homo sapiens_hsa040120.73339853
51Viral carcinogenesis_Homo sapiens_hsa052030.71838118
52VEGF signaling pathway_Homo sapiens_hsa043700.71127618
53Apoptosis_Homo sapiens_hsa042100.69593633
54Melanogenesis_Homo sapiens_hsa049160.68615681
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68346443
56Glioma_Homo sapiens_hsa052140.68317637
57Systemic lupus erythematosus_Homo sapiens_hsa053220.67025198
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66031605
59Endometrial cancer_Homo sapiens_hsa052130.65794700
60Pathways in cancer_Homo sapiens_hsa052000.64834550
61Bladder cancer_Homo sapiens_hsa052190.64639081
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62168199
63Herpes simplex infection_Homo sapiens_hsa051680.61334132
64Alcoholism_Homo sapiens_hsa050340.60462773
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59511742
66Protein export_Homo sapiens_hsa030600.56665303
67Measles_Homo sapiens_hsa051620.55390171
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55200394
69Influenza A_Homo sapiens_hsa051640.54668320
70Prostate cancer_Homo sapiens_hsa052150.54200912
71Prion diseases_Homo sapiens_hsa050200.53814087
72Small cell lung cancer_Homo sapiens_hsa052220.53041761
73Carbon metabolism_Homo sapiens_hsa012000.52159695
74Prolactin signaling pathway_Homo sapiens_hsa049170.48448027
75Insulin signaling pathway_Homo sapiens_hsa049100.47956601
76Parkinsons disease_Homo sapiens_hsa050120.47535209
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47264765
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46872004
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46450833
80Vitamin digestion and absorption_Homo sapiens_hsa049770.46011641
81mTOR signaling pathway_Homo sapiens_hsa041500.45940635
82Biosynthesis of amino acids_Homo sapiens_hsa012300.45713835
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45027991
84Cardiac muscle contraction_Homo sapiens_hsa042600.44650191
85Melanoma_Homo sapiens_hsa052180.43982404
86T cell receptor signaling pathway_Homo sapiens_hsa046600.43756656
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.43538660
88Sulfur relay system_Homo sapiens_hsa041220.41941206
89Pentose phosphate pathway_Homo sapiens_hsa000300.40149986
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.39940107
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38693800
92Lysine degradation_Homo sapiens_hsa003100.38480947
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37072903
94Phototransduction_Homo sapiens_hsa047440.36831701
95Proteoglycans in cancer_Homo sapiens_hsa052050.36691271
96Vitamin B6 metabolism_Homo sapiens_hsa007500.36501143
97Non-small cell lung cancer_Homo sapiens_hsa052230.35661021
98Renal cell carcinoma_Homo sapiens_hsa052110.34083434
99Axon guidance_Homo sapiens_hsa043600.32604937
100Selenocompound metabolism_Homo sapiens_hsa004500.31917964
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31430606
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30231380
103Gap junction_Homo sapiens_hsa045400.29760411
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28628981
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28535957
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25782377
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25328667
108Circadian rhythm_Homo sapiens_hsa047100.24410430
109FoxO signaling pathway_Homo sapiens_hsa040680.23325563
110HIF-1 signaling pathway_Homo sapiens_hsa040660.21093648
111Dilated cardiomyopathy_Homo sapiens_hsa054140.20910453
112N-Glycan biosynthesis_Homo sapiens_hsa005100.20226959
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19893611
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19681670
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16066476
116Estrogen signaling pathway_Homo sapiens_hsa049150.16062858
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15334547
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.14874455
119Acute myeloid leukemia_Homo sapiens_hsa052210.14757728
120Ovarian steroidogenesis_Homo sapiens_hsa049130.12414018
121Dorso-ventral axis formation_Homo sapiens_hsa043200.12247961
122Glucagon signaling pathway_Homo sapiens_hsa049220.11265818
123Hepatitis B_Homo sapiens_hsa051610.11027850
124Rap1 signaling pathway_Homo sapiens_hsa040150.11016558
125AMPK signaling pathway_Homo sapiens_hsa041520.10649525
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10452608
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.10057750
128Folate biosynthesis_Homo sapiens_hsa007900.09702640
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.09683710

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